Detailed information for compound 1896605

Basic information

Technical information
  • TDR Targets ID: 1896605
  • Name: [(6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetylo xyacetyl)-6,9-difluoro-11-hydroxy-10,13-dimet hyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclo penta[a]phenanthren-17-yl] acetate
  • MW: 480.498 | Formula: C25H30F2O7
  • H donors: 1 H acceptors: 5 LogP: 2.11 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)O[C@@]1(CC[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2C[C@@H](C2=CC(=O)C=C[C@]12C)F)F)C(=O)COC(=O)C
  • InChi: 1S/C25H30F2O7/c1-13(28)33-12-21(32)24(34-14(2)29)8-6-16-17-10-19(26)18-9-15(30)5-7-22(18,3)25(17,27)20(31)11-23(16,24)4/h5,7,9,16-17,19-20,31H,6,8,10-12H2,1-4H3/t16-,17-,19-,20-,22-,23-,24-,25-/m0/s1
  • InChiKey: RWKMFNKALGKSFN-QWYWQECLSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [(6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetoxyacetyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] acetate
  • acetic acid [(6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetoxy-1-oxoethyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] ester
  • acetic acid [(6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetoxyacetyl)-6,9-difluoro-11-hydroxy-3-keto-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] ester
  • [(6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetyloxyethanoyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] ethanoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.0077 0.1682 0.7173
Trypanosoma cruzi ribonuclease H1, putative 0.0024 0.0196 0.0653
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0036 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1682 0.7173
Loa Loa (eye worm) ctsf protein 0.002 0.0078 0.0078
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0078 0.0043
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0231 0.0805
Onchocerca volvulus 0.004 0.0627 0.53
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0026 0.0244 0.0738
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0078 0.0043
Loa Loa (eye worm) hypoxia-induced factor 1 0.0182 0.464 0.464
Loa Loa (eye worm) hypothetical protein 0.0021 0.0099 0.0099
Echinococcus multilocularis ornithine aminotransferase 0.0026 0.0244 0.0209
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.01 0.2326 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0231 0.0805
Schistosoma mansoni family C12 unassigned peptidase (C12 family) 0.01 0.2326 0.2299
Schistosoma mansoni single-minded 0.0059 0.1166 0.1134
Schistosoma mansoni ubiquitinyl hydrolase-BAP1 (C12 family) 0.0033 0.0432 0.0398
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0367 0.1283
Echinococcus granulosus lamin 0.0033 0.0427 0.0392
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0627 0.0829
Brugia malayi RNase H family protein 0.0024 0.0196 0.0259
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0047 0.0822 0.3397
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0044 0.0738 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0078 0.0043
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0047 0.0822 0.3397
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0036 0.0047
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0627 0.0594
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0627 0.0627
Entamoeba histolytica hypothetical protein 0.0043 0.0734 0.882
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0627 0.0594
Loa Loa (eye worm) hypothetical protein 0.004 0.0627 0.0627
Brugia malayi conserved hypotetical protein 0.0019 0.0036 0.0047
Entamoeba histolytica hypothetical protein 0.0043 0.0734 0.882
Treponema pallidum ribonuclease H (rnhA) 0.0024 0.0196 0.5
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0305 0.0491
Leishmania major hypothetical protein, conserved 0.003 0.0367 0.1401
Trypanosoma brucei ingi protein (ORF1) 0.0026 0.0255 0.091
Leishmania major ribonuclease H1, putative 0.0024 0.0196 0.0653
Leishmania major importin beta-1 subunit, putative 0.0028 0.0305 0.1128
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0627 0.0627
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1682 0.7173
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0427 0.0427
Entamoeba histolytica hypothetical protein 0.0043 0.0734 0.882
Loa Loa (eye worm) hypothetical protein 0.004 0.0627 0.0627
Plasmodium vivax importin-beta 2, putative 0.0035 0.049 0.1833
Brugia malayi RNase H family protein 0.0024 0.0196 0.0259
Trypanosoma cruzi cysteine peptidase, Clan CA, family C19, putative 0.0031 0.0372 0.1422
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1682 0.7173
Onchocerca volvulus 0.002 0.0078 0.0382
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0627 0.0627
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0047 0.0822 0.1612
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase isozyme L3, putative 0.01 0.2326 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0059 0.1166 0.1134
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0367 0.1283
Leishmania major GTP-binding protein, putative 0.0026 0.0231 0.0805
Schistosoma mansoni importin beta-1 0.0035 0.049 0.0456
Trichomonas vaginalis Clan CA, family C12, ubiquitin hydrolase-like cysteine peptidase 0.01 0.2326 0.4875
Plasmodium vivax ornithine aminotransferase, putative 0.0026 0.0244 0.0738
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0627 0.0829
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0627 0.0627
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0627 0.0627
Brugia malayi nuclear receptor RXR 0.0021 0.0099 0.0131
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0036
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0627 0.0594
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0255 0.091
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0231 0.0805
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.049 0.1833
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0734 0.0701
Echinococcus multilocularis importin subunit beta 1 0.0035 0.049 0.0456
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0427 0.0564
Brugia malayi nuclear receptor NHR-67 0.0019 0.0036 0.0047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1682 0.7173
Echinococcus multilocularis lamin 0.0033 0.0427 0.0392
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0036
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0305 0.0491
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0627 0.0627
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0627 0.0594
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1682 0.7173
Brugia malayi Cathepsin L-like precursor 0.002 0.0078 0.0103
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0627 0.0594
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1577 0.6668
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0627 0.53
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0108 0.2544 0.2517
Brugia malayi Cathepsin L-like precursor 0.002 0.0078 0.0103
Loa Loa (eye worm) hypothetical protein 0.0033 0.0427 0.0427
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0026 0.0244 0.5
Schistosoma mansoni family C12 unassigned peptidase (C12 family) 0.01 0.2326 0.2299
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0627 0.0594
Leishmania major cathepsin L-like protease 0.002 0.0078 0.0135
Brugia malayi Cytochrome P450 family protein 0.0019 0.0047 0.0063
Trichomonas vaginalis ribonuclease H1, putative 0.0024 0.0196 0.0256
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0627 0.0829
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0627 0.53
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0099 0.0064
Trypanosoma brucei RNA helicase, putative 0.0092 0.209 0.8965
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0627 0.0829
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0036 0.0047
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0036
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0033 0.0432 0.1688
Toxoplasma gondii ribonuclease HI protein 0.0024 0.0196 0.0525
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0627 0.0829
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0026 0.0244 0.0323
Loa Loa (eye worm) hypothetical protein 0.01 0.2316 0.2316
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0099 0.0064
Echinococcus multilocularis snurportin 1 0.0372 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1577 0.1547
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0026 0.0244 0.0209
Schistosoma mansoni hypothetical protein 0.0058 0.1152 0.112
Brugia malayi bHLH-PAS transcription factor 0.0043 0.0735 0.0971
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0627 0.0594
Onchocerca volvulus Cathepsin L homolog 0.002 0.0078 0.0382
Entamoeba histolytica hypothetical protein 0.0028 0.0305 0.3044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1682 0.7173
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase isozyme 0.0033 0.0432 0.0398
Schistosoma mansoni ran 0.0026 0.0231 0.0196
Brugia malayi nuclear hormone receptor 0.0019 0.0036 0.0047
Schistosoma mansoni survival motor neuron protein 0.0058 0.1152 0.112
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0036 0.0047
Trypanosoma cruzi ribonuclease H1, putative 0.0024 0.0196 0.0653
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0231 0.0196
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0627 0.0594
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0184 0.4689 1
Echinococcus granulosus Aminotransferase class III 0.0026 0.0244 0.0209
Echinococcus granulosus ornithine aminotransferase 0.0026 0.0244 0.0209
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.049 0.1944
Schistosoma mansoni thyroid hormone receptor 0.004 0.0627 0.0594
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0627 0.0594
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0627 0.0627
Schistosoma mansoni coup transcription factor 0.004 0.0627 0.0594
Onchocerca volvulus 0.002 0.0078 0.0382
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0627 0.0594
Loa Loa (eye worm) hypothetical protein 0.0021 0.0099 0.0099
Echinococcus multilocularis ribonuclease H1 0.0024 0.0196 0.0161
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0305 0.0491
Schistosoma mansoni lamin 0.0033 0.0427 0.0392
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0627 0.0594
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0047 0.0047
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0367 0.1401
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0099 0.0131
Leishmania major cathepsin L-like protease 0.002 0.0078 0.0135
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0627 0.0829
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase isozyme L3 0.01 0.2326 1
Echinococcus multilocularis ornithine aminotransferase 0.0026 0.0244 0.0209
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0026 0.0244 0.0424
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0734 0.0701
Schistosoma mansoni hypothetical protein 0.0092 0.209 0.2062
Mycobacterium ulcerans acetylornithine aminotransferase 0.0026 0.0244 0.0424
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0627 0.0594
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0627 0.0829
Loa Loa (eye worm) hypothetical protein 0.0021 0.0099 0.0099
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0026 0.0255 0.091
Loa Loa (eye worm) ubiquitin C-terminal hydrolase UCH-L5 0.0033 0.0432 0.0432
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0078 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0627 0.0829
Leishmania major ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C12, putative 0.0033 0.0432 0.1688
Brugia malayi nuclear receptor NHR-88 0.004 0.0627 0.0829
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0627 0.0594
Brugia malayi RNA, U transporter 1 0.0099 0.2303 0.3042
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase isozyme 0.01 0.2326 0.2299
Brugia malayi Cytochrome P450 family protein 0.0019 0.0047 0.0063
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0033 0.0432 0.1688
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1577 0.3296
Brugia malayi hypothetical protein 0.0043 0.0734 0.097
Brugia malayi hypothetical protein 0.002 0.0062 0.0082
Schistosoma mansoni nuclear hormone receptor 0.004 0.0627 0.0594
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0036 0.0036
Brugia malayi Importin beta-1 subunit 0.0035 0.049 0.0648
Brugia malayi steroid hormone receptor 0.004 0.0627 0.0829
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0627 0.0594
Brugia malayi RNase H family protein 0.0024 0.0196 0.0259
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase BAP1 0.0033 0.0432 0.0398
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0627 0.0627
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1577 0.3296
Leishmania major cathepsin L-like protease 0.0077 0.1682 0.7173
Schistosoma mansoni lamin 0.0033 0.0427 0.0392
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0734 0.0701
Schistosoma mansoni hypothetical protein 0.0372 1 1
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0627 0.0829
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0036
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0078 0.0043
Brugia malayi hypothetical protein 0.0286 0.7568 1
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0078 0.0043
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0026 0.0244 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0036 0.0036
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0627 0.0594
Loa Loa (eye worm) hypothetical protein 0.0108 0.2544 0.2544
Brugia malayi hypothetical protein 0.0021 0.0099 0.0131
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0026 0.0244 0.0424
Brugia malayi Cathepsin L-like precursor 0.002 0.0078 0.0103
Onchocerca volvulus 0.0033 0.0427 0.3505
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0627 0.0594
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0367 0.1283
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1682 0.7173
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0036
Schistosoma mansoni ubiquitinyl hydrolase-UCH37 (C12 family) 0.0033 0.0432 0.0398
Onchocerca volvulus 0.002 0.0078 0.0382
Brugia malayi nuclear receptor RXR 0.0019 0.0036 0.0047
Brugia malayi hypoxia-induced factor 1 0.0182 0.464 0.6131
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase isozyme 0.0033 0.0432 0.0398
Schistosoma mansoni phosphoglucomutase 0.0024 0.0196 0.0161
Echinococcus granulosus intermediate filament protein 0.0033 0.0427 0.0392
Schistosoma mansoni hypothetical protein 0.0043 0.0734 0.0701
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0036 0.0047
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0044 0.0738 0.2935
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1577 0.1547
Brugia malayi Ubiquitin carboxyl-terminal hydrolase, family 1 protein 0.01 0.2326 0.3074
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0231 0.0231
Leishmania major cathepsin L-like protease 0.002 0.0078 0.0135
Onchocerca volvulus Ribonuclease H1 homolog 0.0024 0.0196 0.1439
Loa Loa (eye worm) hypothetical protein 0.01 0.2316 0.2316
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0078 0.0135
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0627 0.0829
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0033 0.0432 0.1688
Plasmodium falciparum importin beta, putative 0.0035 0.049 0.1833
Loa Loa (eye worm) DR-78 0.0019 0.0036 0.0036
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0627 0.0594
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0184 0.4689 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0036
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase BAP1 0.0033 0.0432 0.0398
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0627 0.0594
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0044 0.0738 0.0975
Trypanosoma brucei ribonuclease H1 0.0024 0.0196 0.0653
Onchocerca volvulus 0.0043 0.0735 0.6265
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 5 0.0042 0.0683 0.0649
Loa Loa (eye worm) hypothetical protein 0.004 0.0627 0.0627
Trypanosoma cruzi cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0683 0.2787
Echinococcus multilocularis lamin dm0 0.0033 0.0427 0.0392
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0044 0.0738 0.2935
Loa Loa (eye worm) hypothetical protein 0.0021 0.0099 0.0099
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0036 0.0047
Onchocerca volvulus 0.0033 0.0427 0.3505
Schistosoma mansoni phosphoglucomutase 0.0024 0.0196 0.0161
Echinococcus granulosus importin subunit beta 1 0.0035 0.049 0.0456
Brugia malayi Cathepsin L-like precursor 0.002 0.0078 0.0103
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0078 0.0103
Brugia malayi tailless protein 0.0019 0.0036 0.0047
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0036
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1577 0.3296
Loa Loa (eye worm) hypothetical protein 0.01 0.2316 0.2316
Trypanosoma brucei unspecified product 0.0026 0.0255 0.091
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 0.0108 0.2544 0.2517
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0627 0.53
Brugia malayi nuclear hormone receptor 0.004 0.0627 0.0829
Leishmania major cathepsin L-like protease 0.002 0.0078 0.0135
Loa Loa (eye worm) hypothetical protein 0.004 0.0627 0.0627
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0627 0.0594
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0184 0.4689 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1682 0.7173
Trichomonas vaginalis ran, putative 0.0026 0.0231 0.0331
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0036
Schistosoma mansoni intermediate filament proteins 0.0033 0.0427 0.0392
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.7568 0.7559
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0367 0.1401
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.1493 0.6345
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0231 0.0639
Loa Loa (eye worm) hypothetical protein 0.004 0.0627 0.0627
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0047 0.0822 0.3307
Mycobacterium tuberculosis Probable aminotransferase 0.0184 0.4689 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0627 0.0829
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase, family 1 protein 0.0033 0.0432 0.1574
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0627 0.0829
Brugia malayi Cathepsin L-like precursor 0.002 0.0078 0.0103
Loa Loa (eye worm) hypothetical protein 0.0032 0.041 0.041
Brugia malayi Cathepsin L-like precursor 0.002 0.0078 0.0103
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1577 0.2999
Loa Loa (eye worm) hypothetical protein 0.0021 0.0099 0.0099
Onchocerca volvulus Cathepsin L homolog 0.002 0.0078 0.0382
Loa Loa (eye worm) hypothetical protein 0.0031 0.0372 0.0372
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase isozyme 0.01 0.2326 0.2299
Loa Loa (eye worm) hypothetical protein 0.0035 0.049 0.049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1682 0.7173
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0627 0.0829
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0627 0.0594
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0367 0.1401
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0036
Echinococcus multilocularis cysteine protease 0.002 0.0078 0.0043
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0078 0.0078
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 5 0.0031 0.0372 0.0337
Plasmodium falciparum deubiquinating/deneddylating enzyme 0.0033 0.0432 0.1574
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0231 0.0679
Loa Loa (eye worm) hypothetical protein 0.01 0.2326 0.2326
Onchocerca volvulus 0.0058 0.1152 1
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0427 0.0427
Loa Loa (eye worm) cysteine protease 0.002 0.0078 0.0078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1682 0.7173
Schistosoma mansoni thyroid hormone receptor 0.004 0.0627 0.0594
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1682 0.7173
Echinococcus granulosus lamin dm0 0.0033 0.0427 0.0392
Onchocerca volvulus 0.002 0.0078 0.0382
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0036 0.0047
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1577 0.1547
Loa Loa (eye worm) hypothetical protein 0.004 0.0627 0.0627
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.1682 0.7173
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase, putative 0.0033 0.0432 0.4759
Loa Loa (eye worm) hypothetical protein 0.004 0.0627 0.0627
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase isozyme 0.0033 0.0432 0.0398
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 5 0.0031 0.0372 0.0337
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0231 0.0305
Brugia malayi ubiquitin C-terminal hydrolase UCH-L5 0.0033 0.0432 0.0571
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.7568 0.7559
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0305 0.1128
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0036
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0047 0.0822 0.3397
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0047 0.0047
Entamoeba histolytica hypothetical protein 0.0033 0.0432 0.4759
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0231 0.0196
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1682 0.7173
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase UCHL3 0.01 0.2326 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0078 0.0043
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0627 0.0594
Schistosoma mansoni family C12 unassigned peptidase (C12 family) 0.01 0.2326 0.2299
Onchocerca volvulus 0.002 0.0078 0.0382
Echinococcus multilocularis Aminotransferase class III 0.0026 0.0244 0.0209
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0026 0.0244 0.0424
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0036
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0078 0.0043
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0078 0.0043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1682 0.7173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1682 0.7173
Onchocerca volvulus 0.002 0.0078 0.0382
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0231 0.0679
Mycobacterium ulcerans putative regulatory protein 0.0043 0.0735 0.1481
Loa Loa (eye worm) hypothetical protein 0.01 0.2316 0.2316
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.1152 0.1522
Schistosoma mansoni ubiquitinyl hydrolase-UCH37 (C12 family) 0.0033 0.0432 0.0398
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0627 0.0829
Trypanosoma brucei ingi protein (ORF1) 0.0026 0.0255 0.091
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0627 0.0594
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.01 0.2326 1
Brugia malayi hypothetical protein 0.0197 0.5071 0.67
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0367 0.1283
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0099 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0627 0.0829
Plasmodium vivax ubiquitin C-terminal hydrolase, family 1, putative 0.0033 0.0432 0.1574
Echinococcus multilocularis transfer RNA-Lys 0.0043 0.0735 0.0702
Brugia malayi hypothetical protein 0.0019 0.0036 0.0047
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 0.0108 0.2544 0.2517
Echinococcus multilocularis cysteine protease 0.002 0.0078 0.0043
Loa Loa (eye worm) hypothetical protein 0.003 0.0367 0.0367
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0078
Echinococcus granulosus cathepsin l1 0.002 0.0078 0.0043
Echinococcus granulosus ribonuclease H1 0.0024 0.0196 0.0161
Schistosoma mansoni phosphoglucomutase 0.0024 0.0196 0.0161
Trichomonas vaginalis Clan CA, family C12, ubiquitin hydrolase-like cysteine peptidase 0.01 0.2326 0.4875
Onchocerca volvulus Cathepsin F homolog 0.002 0.0078 0.0382
Onchocerca volvulus 0.002 0.0078 0.0382
Leishmania major cysteine peptidase A (CPA) 0.002 0.0078 0.0135
Leishmania major ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C12, putative 0.01 0.2326 1
Brugia malayi intermediate filament protein 0.0033 0.0427 0.0564
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0627 0.0594
Loa Loa (eye worm) hypothetical protein 0.0286 0.7568 0.7568
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0026 0.0244 0.0424
Echinococcus multilocularis musashi 0.0033 0.0427 0.0392
Brugia malayi ecdysone receptor 0.0019 0.0036 0.0047
Schistosoma mansoni ran 0.0026 0.0231 0.0196
Leishmania major cathepsin L-like protease 0.0077 0.1682 0.7173
Brugia malayi PAS domain containing protein 0.0059 0.1166 0.154
Loa Loa (eye worm) hypothetical protein 0.01 0.2316 0.2316
Brugia malayi hypothetical protein 0.0021 0.0099 0.0131
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0184 0.4689 1
Brugia malayi hypothetical protein 0.003 0.0367 0.0485
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0108 0.2544 0.3361
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0047 0.0822 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0627 0.0594
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.1217 0.5131
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1577 0.6713
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0047 0.0822 0.0789
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0044 0.0738 0.0738
Leishmania major cathepsin L-like protease 0.002 0.0078 0.0135
Brugia malayi hypothetical protein 0.0019 0.0036 0.0047
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 1 1
Loa Loa (eye worm) fibroinase 0.002 0.0078 0.0078
Entamoeba histolytica Ran family GTPase 0.0026 0.0231 0.2053
Echinococcus granulosus FTZ F1 alpha 0.004 0.0627 0.0594
Brugia malayi ecdysteroid receptor 0.004 0.0627 0.0829
Entamoeba histolytica hypothetical protein 0.0043 0.0734 0.882
Plasmodium falciparum ornithine aminotransferase 0.0026 0.0244 0.0738
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0099 0.0064
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0047 0.0047
Mycobacterium ulcerans L-lysine aminotransferase 0.0026 0.0244 0.0424
Echinococcus granulosus single minded 2 0.0043 0.0735 0.0702
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0627 0.0829
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0627 0.0594
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.049 0.1944
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0627 0.0594
Mycobacterium ulcerans hypothetical protein 0.0184 0.4689 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0099 0.0099
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0047 0.0822 0.0789
Loa Loa (eye worm) hypothetical protein 0.004 0.0627 0.0627
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0099 0.0064
Brugia malayi nuclear receptor NHR-88 0.0019 0.0036 0.0047
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1577 0.1547
Loa Loa (eye worm) hypothetical protein 0.0197 0.5071 0.5071
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0231 0.0679

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.