TDR Targets

Basic information

Technical information

TDR Targets ID: 1900489
Name: 4-[2-(butyl-(2-phenylethyl)amino)ethyl]benzen e-1,2-diol
MW: 313.434 | Formula: C20H27NO2
H donors: 2 H acceptors: 2 LogP: 4.72 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCCCN(CCc1ccccc1)CCc1ccc(c(c1)O)O
InChi: 1S/C20H27NO2/c1-2-3-13-21(14-11-17-7-5-4-6-8-17)15-12-18-9-10-19(22)20(23)16-18/h4-10,16,22-23H,2-3,11-15H2,1H3
InChiKey: PZZWEXJGFWHIDV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[2-(butyl-(2-phenylethyl)amino)ethyl]pyrocatechol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	cysteine proteinase, putative	0.0526	0.5962	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0526	0.5962	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0282	0.3067	0.2956
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0116	0.1094	0.2534
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0526	0.5962	1
Onchocerca volvulus	Cathepsin F homolog	0.0526	0.5962	1
Giardia lamblia	Cathepsin L precursor	0.0116	0.1094	0.2534
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0116	0.1094	0.1094
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0526	0.5962	1
Echinococcus multilocularis	serotonin transporter	0.0278	0.3021	0.2909
Entamoeba histolytica	cysteine protease, putative	0.0116	0.1094	0.1611
Entamoeba histolytica	cysteine protease, putative	0.0282	0.3067	0.5012
Loa Loa (eye worm)	hypothetical protein	0.036	0.3989	0.3989
Leishmania major	cathepsin L-like protease	0.0526	0.5962	1
Giardia lamblia	Encystation-specific protease	0.0116	0.1094	0.2534
Giardia lamblia	Cathepsin L precursor	0.0116	0.1094	0.2534
Brugia malayi	histone deacetylase 11	0.0037	0.0158	0.0158
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0278	0.3021	0.3021
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.036	0.3989	0.6599
Onchocerca volvulus		0.0047	0.0277	0.0205
Loa Loa (eye worm)	histone deacetylase 1	0.0037	0.0158	0.0158
Leishmania major	cathepsin L-like protease	0.0526	0.5962	1
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1094	0.1094
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.1094	0.1611
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0116	0.1094	0.1094
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0116	0.1094	0.1094
Brugia malayi	histone deacetylase 1 (HD1)	0.0037	0.0158	0.0158
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0526	0.5962	1
Entamoeba histolytica	cysteine protease, putative	0.0282	0.3067	0.5012
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0526	0.5962	0.5897
Plasmodium vivax	vivapain-1	0.0282	0.3067	0.5012
Onchocerca volvulus	Cathepsin L homolog	0.0116	0.1094	0.1611
Entamoeba histolytica	cysteine proteinase, putative	0.036	0.3989	0.6599
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0282	0.3067	0.5012
Plasmodium falciparum	serine repeat antigen 9	0.0116	0.1094	0.1611
Giardia lamblia	Cathepsin L precursor	0.0116	0.1094	0.2534
Schistosoma mansoni	cathepsin F (C01 family)	0.0526	0.5962	0.5962
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0116	0.1094	0.1611
Trypanosoma cruzi	cysteine peptidase, putative	0.0526	0.5962	0.5897
Loa Loa (eye worm)	hypothetical protein	0.0278	0.3021	0.3021
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0047	0.0277	0.0277
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0116	0.1094	0.1611
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0526	0.5962	1
Onchocerca volvulus		0.0526	0.5962	1
Brugia malayi	Cathepsin L-like precursor	0.0526	0.5962	0.5962
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0116	0.1094	0.1611
Giardia lamblia	Cathepsin L precursor	0.0116	0.1094	0.2534
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0526	0.5962	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0526	0.5962	0.5962
Brugia malayi	Papain family cysteine protease containing protein	0.0116	0.1094	0.1094
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0866	1	1
Entamoeba histolytica	cysteine protease, putative	0.0282	0.3067	0.5012
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0526	0.5962	1
Entamoeba histolytica	cysteine proteinase, putative	0.0282	0.3067	0.5012
Loa Loa (eye worm)	serotonin transporter b	0.0278	0.3021	0.3021
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1094	0.1094
Loa Loa (eye worm)	hypothetical protein	0.0866	1	1
Loa Loa (eye worm)	hypothetical protein	0.036	0.3989	0.3989
Giardia lamblia	Cathepsin B precursor	0.0116	0.1094	0.2534
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0047	0.0277	0.0121
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0116	0.1094	0.1094
Echinococcus multilocularis	cysteine protease	0.0526	0.5962	0.5897
Entamoeba histolytica	cysteine protease, putative	0.0282	0.3067	0.5012
Brugia malayi	Papain family cysteine protease containing protein	0.0116	0.1094	0.1094
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0526	0.5962	1
Schistosoma mansoni	histone deacetylase	0.0037	0.0158	0.0158
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0526	0.5962	1
Toxoplasma gondii	cathepsin CPC1	0.0116	0.1094	0.1611
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0047	0.0277	0.0277
Loa Loa (eye worm)	histone deacetylase 7A	0.0037	0.0158	0.0158
Plasmodium falciparum	transporter, putative	0.0047	0.0277	0.0205
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0116	0.1094	0.1611
Brugia malayi	Cathepsin L-like precursor	0.0166	0.169	0.169
Loa Loa (eye worm)	hypothetical protein	0.0278	0.3021	0.3021
Loa Loa (eye worm)	norepinephrine transporter	0.0278	0.3021	0.3021
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0866	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0116	0.1094	0.1611
Entamoeba histolytica	cysteine protease, putative	0.0282	0.3067	0.5012
Echinococcus multilocularis	cathepsin b	0.0866	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0526	0.5962	0.5897
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0116	0.1094	0.1611
Plasmodium falciparum	serine repeat antigen 7	0.0116	0.1094	0.1611
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0047	0.0277	0.0277
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0116	0.1094	0.1611
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0282	0.3067	0.5012
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0116	0.1094	0.1094
Leishmania major	cathepsin L-like protease	0.0526	0.5962	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0526	0.5962	1
Entamoeba histolytica	cysteine protease, putative	0.0282	0.3067	0.5012
Brugia malayi	Histone deacetylase 1	0.0037	0.0158	0.0158
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0526	0.5962	1
Plasmodium falciparum	serine repeat antigen 6	0.0116	0.1094	0.1611
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0526	0.5962	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.0116	0.1094	0.1611
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0282	0.3067	0.3067
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0116	0.1094	0.1094
Schistosoma mansoni	histone deacetylase 4 5	0.0037	0.0158	0.0158
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0116	0.1094	0.1611
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0166	0.169	0.169
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0526	0.5962	0.5962
Giardia lamblia	Cathepsin L-like protease	0.0116	0.1094	0.2534
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0047	0.0277	0.0121
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0526	0.5962	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.036	0.3989	0.6599
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0526	0.5962	1
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0047	0.0277	0.0121
Echinococcus granulosus	cathepsin b	0.0866	1	1
Giardia lamblia	Hypothetical protein	0.0116	0.1094	0.2534
Toxoplasma gondii	hypothetical protein	0.0047	0.0277	0.0205
Entamoeba histolytica	cysteine protease, putative	0.0282	0.3067	0.5012
Loa Loa (eye worm)	ctsf protein	0.0526	0.5962	0.5962
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0047	0.0277	0.0121
Onchocerca volvulus	Cathepsin L homolog	0.0526	0.5962	1
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0047	0.0277	0.0121
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0116	0.1094	0.1611
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0526	0.5962	1
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1094	0.1094
Brugia malayi	Cathepsin L-like precursor	0.0526	0.5962	0.5962
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0047	0.0277	0.0205
Brugia malayi	cathepsin F-like cysteine proteinase	0.0116	0.1094	0.1094
Schistosoma mansoni	histone deacetylase	0.0037	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1094	0.1094
Loa Loa (eye worm)	cathepsin B	0.0348	0.3848	0.3848
Giardia lamblia	Cathepsin B precursor	0.0348	0.3848	1
Giardia lamblia	Cathepsin B precursor	0.0116	0.1094	0.2534
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0278	0.3021	0.3021
Loa Loa (eye worm)	fibroinase	0.0526	0.5962	0.5962
Schistosoma mansoni	cathepsin S (C01 family)	0.0116	0.1094	0.1094
Plasmodium falciparum	serine repeat antigen 3	0.0116	0.1094	0.1611
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0277	0.0277
Brugia malayi	cathepsin L-like cysteine proteinase	0.0116	0.1094	0.1094
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.1094	0.1611
Schistosoma mansoni	cathepsin B (C01 family)	0.0116	0.1094	0.1094
Trypanosoma cruzi	major cysteine proteinase, putative	0.0116	0.1094	0.095
Leishmania major	cathepsin L-like protease	0.0526	0.5962	1
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0047	0.0277	0.0121
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0116	0.1094	0.1094
Schistosoma mansoni	cathepsin s	0.0166	0.169	0.169
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0526	0.5962	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0526	0.5962	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0526	0.5962	1
Giardia lamblia	Cathepsin L precursor	0.0116	0.1094	0.2534
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0526	0.5962	1
Leishmania major	cathepsin L-like protease	0.0526	0.5962	1
Brugia malayi	Cathepsin L-like precursor	0.0526	0.5962	0.5962
Plasmodium falciparum	serine repeat antigen 8	0.0116	0.1094	0.1611
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0526	0.5962	1
Plasmodium falciparum	serine repeat antigen 4	0.0116	0.1094	0.1611
Entamoeba histolytica	cysteine proteinase, putative	0.0526	0.5962	1
Leishmania major	cathepsin L-like protease	0.0526	0.5962	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0526	0.5962	1
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0047	0.0277	0.0205
Trypanosoma cruzi	cysteine proteinase, putative	0.0282	0.3067	0.2956
Brugia malayi	Papain family cysteine protease containing protein	0.0282	0.3067	0.3067
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0047	0.0277	0.0277
Onchocerca volvulus		0.0526	0.5962	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0116	0.1094	0.1611
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0116	0.1094	0.1611
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0116	0.1094	0.1611
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0526	0.5962	1
Brugia malayi	Cathepsin L-like precursor	0.036	0.3989	0.3989
Loa Loa (eye worm)	histone deacetylase	0.0037	0.0158	0.0158
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0116	0.1094	0.1611
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0116	0.1094	0.1611
Entamoeba histolytica	cysteine protease, putative	0.0282	0.3067	0.5012
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0348	0.3848	0.3749
Giardia lamblia	Hypothetical protein	0.0116	0.1094	0.2534
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1094	0.1094
Schistosoma mansoni	sodium/chloride dependent transporter	0.0278	0.3021	0.3021
Loa Loa (eye worm)	cysteine protease	0.0526	0.5962	0.5962
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0526	0.5962	0.5897
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0526	0.5962	1
Echinococcus granulosus	cathepsin l1	0.036	0.3989	0.3892
Leishmania major	cathepsin L-like protease	0.0526	0.5962	1
Echinococcus granulosus	cathepsin b	0.0866	1	1
Onchocerca volvulus		0.0526	0.5962	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0526	0.5962	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0116	0.1094	0.1094
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0047	0.0277	0.5
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0866	1	1
Giardia lamblia	Cysteine protease	0.0116	0.1094	0.2534
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0116	0.1094	0.1094
Loa Loa (eye worm)	hypothetical protein	0.0278	0.3021	0.3021
Onchocerca volvulus		0.0278	0.3021	0.4933
Entamoeba histolytica	hypothetical protein	0.0116	0.1094	0.1611
Entamoeba histolytica	cysteine proteinase, putative	0.0282	0.3067	0.5012
Entamoeba histolytica	cysteine proteinase 1, putative	0.0282	0.3067	0.5012
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0035	0.0131	0.0131
Entamoeba histolytica	cysteine proteinase, putative	0.0282	0.3067	0.5012
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0282	0.3067	0.3067
Schistosoma mansoni	cathepsin C	0.0116	0.1094	0.1094
Entamoeba histolytica	cysteine protease, putative	0.0116	0.1094	0.1611
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0047	0.0277	0.0277
Brugia malayi	Papain family cysteine protease containing protein	0.0116	0.1094	0.1094
Entamoeba histolytica	cysteine protease, putative	0.0282	0.3067	0.5012
Giardia lamblia	Cysteine protease	0.0116	0.1094	0.2534
Echinococcus granulosus	cathepsin L cysteine protease	0.0282	0.3067	0.2956
Plasmodium vivax	unspecified product	0.0282	0.3067	0.5012
Entamoeba histolytica	cysteine protease, putative	0.0526	0.5962	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0348	0.3848	0.6357
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0277	0.0277
Brugia malayi	Cathepsin L-like precursor	0.0526	0.5962	0.5962
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0047	0.0277	0.0277
Giardia lamblia	Cathepsin L-like protease	0.0116	0.1094	0.2534
Plasmodium vivax	vivapain-2	0.0526	0.5962	1
Onchocerca volvulus		0.0526	0.5962	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0116	0.1094	0.1611
Loa Loa (eye worm)	hypothetical protein	0.0166	0.169	0.169
Schistosoma mansoni	histone deacetylase 4 5	0.0037	0.0158	0.0158
Brugia malayi	cathepsin F-like cysteine proteinase	0.0166	0.169	0.169
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0116	0.1094	0.1611
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0116	0.1094	0.1611
Onchocerca volvulus		0.0047	0.0277	0.0205
Entamoeba histolytica	cysteine protease, putative	0.0116	0.1094	0.1611
Treponema pallidum	sodium- and chloride- dependent transporter	0.0278	0.3021	0.5
Brugia malayi	Papain family cysteine protease containing protein	0.0282	0.3067	0.3067
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0282	0.3067	0.5012
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0348	0.3848	0.6357
Loa Loa (eye worm)	hypothetical protein	0.0526	0.5962	0.5962
Echinococcus granulosus	sodium and chloride dependent glycine	0.0047	0.0277	0.0121
Entamoeba histolytica	cysteine proteinase, putative	0.0282	0.3067	0.5012
Echinococcus granulosus	cysteine protease	0.0282	0.3067	0.2956
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0116	0.1094	0.1611
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0526	0.5962	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.036	0.3989	0.3989
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0035	0.0131	0.0131
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0047	0.0277	0.0277
Echinococcus granulosus	serotonin transporter	0.0278	0.3021	0.2909
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0116	0.1094	0.1094
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0047	0.0277	0.0277
Loa Loa (eye worm)	histone deacetylase 11	0.0037	0.0158	0.0158
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0047	0.0277	0.0277
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0526	0.5962	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0116	0.1094	0.1611
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0282	0.3067	0.5012
Toxoplasma gondii	cathepsin CPC2	0.0116	0.1094	0.1611
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0047	0.0277	0.0277
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0116	0.1094	0.1094
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0526	0.5962	0.5897
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0116	0.1094	0.1094
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0348	0.3848	0.3848
Brugia malayi	histone deacetylase 3 (HD3)	0.0037	0.0158	0.0158
Onchocerca volvulus		0.0526	0.5962	1
Brugia malayi	Cathepsin L-like precursor	0.0526	0.5962	0.5962
Schistosoma mansoni	cathepsin F (C01 family)	0.036	0.3989	0.3989
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0526	0.5962	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0526	0.5962	1
Loa Loa (eye worm)	histone deacetylase 3	0.0037	0.0158	0.0158
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0047	0.0277	0.0277
Onchocerca volvulus	Cathepsin L homolog	0.0526	0.5962	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0277	0.0277
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0526	0.5962	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0116	0.1094	0.1611
Brugia malayi	Histone deacetylase family protein	0.0037	0.0158	0.0158
Plasmodium vivax	vivapain-3	0.0282	0.3067	0.5012
Echinococcus granulosus	cathepsin L	0.0282	0.3067	0.2956
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0131	0.0131
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0035	0.0131	0.0131
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0047	0.0277	0.0205
Plasmodium vivax	vivapain-2	0.0526	0.5962	1
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0116	0.1094	0.1611
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0047	0.0277	0.0277
Trypanosoma cruzi	cysteine protease, putative	0.0282	0.3067	0.2956
Trypanosoma cruzi	cysteine peptidase, putative	0.0526	0.5962	0.5897
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0047	0.0277	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0277	0.0277
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0866	1	1
Plasmodium vivax	amine transporter, putative	0.0047	0.0277	0.0205
Echinococcus granulosus	sodium and chloride dependent glycine	0.0047	0.0277	0.0121
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0116	0.1094	0.1611
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0526	0.5962	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0116	0.1094	0.2534
Giardia lamblia	Cathepsin B precursor	0.0116	0.1094	0.2534
Plasmodium falciparum	serine repeat antigen 1	0.0116	0.1094	0.1611
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0116	0.1094	0.1611
Entamoeba histolytica	cysteine protease, putative	0.0116	0.1094	0.1611
Plasmodium falciparum	serine repeat antigen 5	0.0116	0.1094	0.1611
Brugia malayi	Histone deacetylase family protein	0.0037	0.0158	0.0158
Onchocerca volvulus		0.036	0.3989	0.6599
Leishmania major	cathepsin L-like protease	0.0526	0.5962	1
Brugia malayi	Cathepsin L-like precursor	0.036	0.3989	0.3989
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0116	0.1094	0.2534
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0526	0.5962	1
Entamoeba histolytica	cysteine protease, putative	0.0282	0.3067	0.5012
Plasmodium falciparum	amino acid transporter, putative	0.0047	0.0277	0.0205
Onchocerca volvulus		0.0116	0.1094	0.1611
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0158	0.0158
Trypanosoma cruzi	major cysteine proteinase, putative	0.0116	0.1094	0.095
Brugia malayi	cathepsin L precursor	0.0116	0.1094	0.1094
Giardia lamblia	Cathepsin B precursor	0.0116	0.1094	0.2534
Giardia lamblia	Cathepsin L precursor	0.0116	0.1094	0.2534
Plasmodium vivax	serine-repeat antigen (SERA)	0.0116	0.1094	0.1611
Brugia malayi	fibroinase precursor	0.0116	0.1094	0.1094
Schistosoma mansoni	sodium/chloride dependent transporter	0.0047	0.0277	0.0277
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0526	0.5962	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0116	0.1094	0.1094
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0277	0.0277
Entamoeba histolytica	cysteine protease, putative	0.0116	0.1094	0.1611
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0158	0.0158
Echinococcus granulosus	cathepsin L	0.0116	0.1094	0.095
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0116	0.1094	0.2534
Echinococcus multilocularis	cathepsin L cysteine protease	0.0526	0.5962	0.5897
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0348	0.3848	0.6357
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0116	0.1094	0.1611
Schistosoma mansoni	sodium/chloride dependent transporter	0.0047	0.0277	0.0277
Entamoeba histolytica	cysteine protease, putative	0.0282	0.3067	0.5012
Giardia lamblia	Cysteine protease	0.0116	0.1094	0.2534
Trypanosoma cruzi	cysteine peptidase, putative	0.0526	0.5962	0.5897
Schistosoma mansoni	histone deacetylase 1 2 3	0.0037	0.0158	0.0158
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0282	0.3067	0.5012
Echinococcus multilocularis	cathepsin L	0.0282	0.3067	0.2956
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0116	0.1094	0.1094
Schistosoma mansoni	histone deacetylase hda2	0.0037	0.0158	0.0158
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0047	0.0277	0.0121
Plasmodium vivax	unspecified product	0.0166	0.169	0.2639
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0116	0.1094	0.1611
Schistosoma mansoni	histone deacetylase hda2	0.0037	0.0158	0.0158
Toxoplasma gondii	cathepsin CPL	0.0526	0.5962	1
Loa Loa (eye worm)	hypothetical protein	0.0166	0.169	0.169
Echinococcus granulosus	cathepsin l1	0.0526	0.5962	0.5897
Toxoplasma gondii	cathepsin B	0.0348	0.3848	0.6357
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1094	0.1094
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0047	0.0277	0.0277
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0526	0.5962	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0116	0.1094	0.1094
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0278	0.3021	0.3021
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0116	0.1094	0.1611
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0047	0.0277	0.0277
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0526	0.5962	1
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0116	0.1094	0.1611
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0047	0.0277	0.0121
Leishmania major	cysteine peptidase A (CPA)	0.0526	0.5962	1
Brugia malayi	Cathepsin L-like precursor	0.0526	0.5962	0.5962
Loa Loa (eye worm)	hypothetical protein	0.0166	0.169	0.169
Entamoeba histolytica	cysteine protease, putative	0.0282	0.3067	0.5012
Entamoeba histolytica	cysteine protease, putative	0.0116	0.1094	0.1611
Echinococcus multilocularis	cathepsin L	0.0116	0.1094	0.095
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0116	0.1094	0.1611
Echinococcus multilocularis	cysteine protease	0.0526	0.5962	0.5897
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0526	0.5962	0.5897
Giardia lamblia	Cathepsin B precursor	0.0348	0.3848	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0116	0.1094	0.1611
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0277	0.0277
Plasmodium vivax	unspecified product	0.0116	0.1094	0.1611
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0166	0.169	0.169
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.036	0.3989	0.3892
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0526	0.5962	0.5962
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0116	0.1094	0.1611
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0526	0.5962	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0526	0.5962	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0526	0.5962	0.5897
Brugia malayi	hypothetical protein	0.0047	0.0277	0.0277
Loa Loa (eye worm)	hypothetical protein	0.036	0.3989	0.3989
Brugia malayi	Papain family cysteine protease containing protein	0.0526	0.5962	0.5962
Entamoeba histolytica	cysteine proteinase 2	0.0282	0.3067	0.5012
Echinococcus multilocularis	cathepsin b	0.0866	1	1
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0116	0.1094	0.1611
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0866	1	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0277	0.0277
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0282	0.3067	0.3067
Onchocerca volvulus		0.0526	0.5962	1
Toxoplasma gondii	hypothetical protein	0.0047	0.0277	0.0205
Onchocerca volvulus		0.0047	0.0277	0.0205
Giardia lamblia	Cathepsin B precursor	0.0348	0.3848	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0526	0.5962	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0526	0.5962	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0116	0.1094	0.1611
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0047	0.0277	0.0121
Trypanosoma cruzi	cysteine peptidase, putative	0.0166	0.169	0.1556
Trypanosoma cruzi	cruzipain precursor, putative	0.0166	0.169	0.1556
Echinococcus multilocularis	cathepsin L cysteine protease	0.0526	0.5962	0.5897
Trypanosoma cruzi	cysteine peptidase, putative	0.0282	0.3067	0.2956
Entamoeba histolytica	cysteine protease, putative	0.0282	0.3067	0.5012
Giardia lamblia	Cysteine protease	0.0116	0.1094	0.2534
Trypanosoma cruzi	cysteine proteinase, putative	0.0282	0.3067	0.2956
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0116	0.1094	0.1611
Plasmodium vivax	hypothetical protein, conserved	0.0047	0.0277	0.0205
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0526	0.5962	1
Brugia malayi	cathepsin L-like precursor	0.036	0.3989	0.3989
Onchocerca volvulus		0.0526	0.5962	1
Plasmodium falciparum	serine repeat antigen 2	0.0116	0.1094	0.1611
Giardia lamblia	Cathepsin B precursor	0.0116	0.1094	0.2534

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3302675

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1900489