Detailed information for compound 1905874

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 259.343 | Formula: C16H21NO2
  • H donors: 0 H acceptors: 1 LogP: 2.62 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)[C@H]1C[C@H]2CCC([C@H]1c1ccccc1)N2C
  • InChi: 1S/C16H21NO2/c1-17-12-8-9-14(17)15(11-6-4-3-5-7-11)13(10-12)16(18)19-2/h3-7,12-15H,8-10H2,1-2H3/t12-,13+,14?,15+/m1/s1
  • InChiKey: KCKMEVZULURHST-VPHRMDQISA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine protease, putative 0.0663 0.2123 0.538
Loa Loa (eye worm) hypothetical protein 0.0293 0.0921 0.0921
Onchocerca volvulus 0.1205 0.3886 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0835 0.2684 0.5946
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0027 0.0027
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1205 0.3886 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0663 0.2123 0.5414
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0027 0.0027
Schistosoma mansoni cathepsin s 0.037 0.1172 0.1172
Schistosoma mansoni smad1 5 8 and 0.0014 0.0016 0.0016
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0293 0.0921 0.2288
Plasmodium falciparum serine repeat antigen 4 0.0293 0.0921 0.2288
Echinococcus granulosus geminin 0.0146 0.0443 0.0443
Loa Loa (eye worm) hypothetical protein 0.037 0.1172 0.1172
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0027 0.0027
Echinococcus multilocularis cathepsin L 0.0663 0.2123 0.2123
Onchocerca volvulus 0.0835 0.2684 0.6886
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Brugia malayi CXXC zinc finger family protein 0.0034 0.008 0.008
Echinococcus multilocularis dnaJ subfamily B 0.0481 0.1532 0.1532
Entamoeba histolytica cysteine protease, putative 0.0663 0.2123 0.538
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1205 0.3886 1
Entamoeba histolytica cysteine protease, putative 0.0293 0.0921 0.2231
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0027 0.0027
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0027 0.0027
Echinococcus multilocularis cysteine protease 0.1205 0.3886 0.3886
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0027 0.0027
Echinococcus granulosus mothers against decapentaplegic 5 0.0014 0.0016 0.0016
Plasmodium vivax vivapain-1 0.0663 0.2123 0.5414
Schistosoma mansoni smad 0.0014 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0663 0.2123 0.4054
Loa Loa (eye worm) MH2 domain-containing protein 0.0014 0.0016 0.0016
Onchocerca volvulus Cathepsin L homolog 0.0293 0.0921 0.2318
Entamoeba histolytica cysteine proteinase 2 0.0663 0.2123 0.538
Schistosoma mansoni neuropeptide receptor 0.0216 0.0673 0.0673
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0004 0.0004
Echinococcus multilocularis Smad4 0.0014 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0027 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Brugia malayi nuclear receptor NHR-88 0.0018 0.0027 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0027 0.0027
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1205 0.3886 0.3886
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1205 0.3886 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1157 0.3729 0.9472
Plasmodium vivax vivapain-2 0.1205 0.3886 1
Loa Loa (eye worm) ctsf protein 0.1205 0.3886 0.3886
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0293 0.0921 0.2288
Loa Loa (eye worm) hypothetical protein 0.0087 0.0252 0.0252
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0835 0.2684 0.2653
Loa Loa (eye worm) histone methyltransferase 0.001 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1205 0.3886 1
Echinococcus multilocularis cathepsin L cysteine protease 0.1205 0.3886 0.3886
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0027 0.0027
Leishmania major cathepsin L-like protease 0.1205 0.3886 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0027 0.0027
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.001 0.0002 0.0002
Plasmodium falciparum cysteine proteinase falcipain 1 0.0663 0.2123 0.5414
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0027 0.0027
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0027 0.0027
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0027 0.0027
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.3087 1 1
Echinococcus granulosus Smad4 0.0014 0.0016 0.0016
Echinococcus granulosus cathepsin L cysteine proteinase 0.1205 0.3886 0.3886
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0293 0.0921 0.2288
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0027 0.0027
Brugia malayi cathepsin Z-like cysteine proteinase 0.0293 0.0921 0.0921
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0027 0.0027
Plasmodium falciparum serine repeat antigen 1 0.0293 0.0921 0.2288
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0027 0.0027
Echinococcus multilocularis geminin 0.0146 0.0443 0.0443
Echinococcus multilocularis neuropeptide receptor 0.0216 0.0673 0.0673
Plasmodium falciparum serine repeat antigen 5 0.0293 0.0921 0.2288
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0293 0.0921 0.2231
Brugia malayi latrophilin 2 splice variant baaae 0.0059 0.0163 0.0163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1205 0.3886 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0163 0.0163
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0027 0.0059 0.0059
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.001 0.0002 0.0002
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0027 0.0059 0.0059
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0293 0.0921 0.2288
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0663 0.2123 0.2123
Entamoeba histolytica cysteine proteinase, putative 0.1205 0.3886 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0027 0.0027
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0027 0.0059 0.0059
Brugia malayi hypothetical protein 0.0014 0.0016 0.0016
Toxoplasma gondii cathepsin B 0.1157 0.3729 0.9593
Plasmodium falciparum cysteine proteinase falcipain 3 0.1205 0.3886 1
Giardia lamblia Cathepsin B precursor 0.1157 0.3729 1
Plasmodium falciparum serine repeat antigen 3 0.0293 0.0921 0.2288
Brugia malayi Smad1 0.0014 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0027 0.0027
Brugia malayi hypothetical protein 0.0022 0.0042 0.0042
Brugia malayi ecdysteroid receptor 0.0018 0.0027 0.0027
Echinococcus multilocularis cathepsin L cysteine protease 0.1205 0.3886 0.3886
Entamoeba histolytica cysteine proteinase, putative 0.0663 0.2123 0.538
Plasmodium vivax unspecified product 0.0663 0.2123 0.5414
Brugia malayi cathepsin Z-like cysteine proteinase 0.0293 0.0921 0.0921
Schistosoma mansoni cathepsin S (C01 family) 0.0293 0.0921 0.0921
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0003 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0027 0.0027
Onchocerca volvulus 0.0034 0.008 0.0136
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0004 0.0004
Loa Loa (eye worm) Smad1 0.0014 0.0016 0.0016
Toxoplasma gondii cathepsin CPC2 0.0293 0.0921 0.2288
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0027 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1205 0.3886 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1205 0.3886 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0835 0.2684 0.2684
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0027 0.0027
Schistosoma mansoni coup transcription factor 0.0018 0.0027 0.0027
Echinococcus multilocularis cathepsin L 0.0293 0.0921 0.0921
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.001 0.0002 0.0002
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1205 0.3886 1
Brugia malayi cathepsin F-like cysteine proteinase 0.037 0.1172 0.1172
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0027 0.0059 0.0059
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0293 0.0921 0.0921
Onchocerca volvulus 0.1205 0.3886 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1205 0.3886 1
Brugia malayi MH2 domain containing protein 0.0208 0.0645 0.0645
Trypanosoma cruzi cysteine peptidase, putative 0.1205 0.3886 0.386
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0027 0.0027
Entamoeba histolytica cysteine protease, putative 0.0293 0.0921 0.2231
Plasmodium falciparum serine repeat antigen 6 0.0293 0.0921 0.2288
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0027 0.0027
Trypanosoma cruzi cysteine proteinase, putative 0.0663 0.2123 0.209
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0293 0.0921 0.2288
Schistosoma mansoni smad1 5 8 and 0.0014 0.0016 0.0016
Brugia malayi nuclear hormone receptor 0.0018 0.0027 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1205 0.3886 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0293 0.0921 0.2288
Brugia malayi Cathepsin L-like precursor 0.1205 0.3886 0.3886
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0835 0.2684 0.5946
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0293 0.0921 0.0921
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0027 0.0027
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0027 0.0027
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1157 0.3729 0.3703
Schistosoma mansoni Smad4 0.0014 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1205 0.3886 1
Schistosoma mansoni hypothetical protein 0.0027 0.0059 0.0059
Echinococcus granulosus cathepsin l1 0.0835 0.2684 0.2684
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0293 0.0921 0.2231
Schistosoma mansoni cathepsin F (C01 family) 0.1205 0.3886 0.3886
Brugia malayi Cathepsin L-like precursor 0.1205 0.3886 0.3886
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1205 0.3886 1
Entamoeba histolytica cysteine proteinase, putative 0.1205 0.3886 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.0202 0.0202
Echinococcus granulosus cathepsin b 0.3087 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0027 0.0027
Echinococcus granulosus cathepsin b 0.3087 1 1
Entamoeba histolytica cysteine protease, putative 0.0663 0.2123 0.538
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0293 0.0921 0.2288
Brugia malayi cathepsin L-like cysteine proteinase 0.0293 0.0921 0.0921
Trypanosoma cruzi cysteine peptidase, putative 0.1205 0.3886 0.386
Plasmodium falciparum serine repeat antigen 9 0.0293 0.0921 0.2288
Echinococcus granulosus cpg binding protein 0.0036 0.0086 0.0086
Entamoeba histolytica cysteine proteinase, putative 0.0663 0.2123 0.538
Brugia malayi Papain family cysteine protease containing protein 0.0293 0.0921 0.0921
Entamoeba histolytica cysteine proteinase, putative 0.0835 0.2684 0.685
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0293 0.0921 0.0921
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0027 0.0027
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1205 0.3886 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0027 0.0027
Trypanosoma cruzi cysteine peptidase, putative 0.0663 0.2123 0.209
Brugia malayi Calcitonin receptor-like protein seb-1 0.0087 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Echinococcus granulosus cathepsin l1 0.1205 0.3886 0.3886
Entamoeba histolytica cysteine protease, putative 0.0663 0.2123 0.538
Plasmodium vivax vivapain-3 0.0663 0.2123 0.5414
Echinococcus multilocularis cysteine protease 0.1205 0.3886 0.3886
Plasmodium vivax serine-repeat antigen (SERA) 0.0293 0.0921 0.2288
Loa Loa (eye worm) latrophilin receptor protein 2 0.0027 0.0059 0.0059
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1157 0.3729 0.3729
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0835 0.2684 0.2684
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0027 0.0027
Entamoeba histolytica cysteine protease, putative 0.0663 0.2123 0.538
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1205 0.3886 0.3886
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0293 0.0921 0.2288
Brugia malayi fibroinase precursor 0.0293 0.0921 0.0921
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1205 0.3886 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1205 0.3886 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0087 0.0252 0.0252
Trypanosoma cruzi cysteine peptidase, putative 0.1205 0.3886 0.386
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0027 0.0027
Brugia malayi Papain family cysteine protease containing protein 0.0293 0.0921 0.0921
Onchocerca volvulus Cathepsin F homolog 0.1205 0.3886 1
Schistosoma mansoni hypothetical protein 0.0027 0.0059 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0027 0.0027
Schistosoma mansoni cpg binding protein 0.0036 0.0086 0.0086
Entamoeba histolytica cysteine protease, putative 0.0663 0.2123 0.538
Loa Loa (eye worm) cathepsin B 0.1157 0.3729 0.3729
Brugia malayi MH1 domain containing protein 0.0014 0.0016 0.0016
Brugia malayi cathepsin L precursor 0.0293 0.0921 0.0921
Loa Loa (eye worm) hypothetical protein 0.0027 0.0059 0.0059
Brugia malayi Cathepsin L-like precursor 0.037 0.1172 0.1172
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Giardia lamblia Cathepsin B precursor 0.1157 0.3729 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0027 0.0027
Plasmodium vivax unspecified product 0.0293 0.0921 0.2288
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1205 0.3886 1
Loa Loa (eye worm) hypothetical protein 0.0293 0.0921 0.0921
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.008 0.008
Brugia malayi Cathepsin L-like precursor 0.1205 0.3886 0.3886
Entamoeba histolytica cysteine protease, putative 0.0293 0.0921 0.2231
Leishmania major cathepsin L-like protease 0.1205 0.3886 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1205 0.3886 1
Trypanosoma cruzi cruzipain precursor, putative 0.1205 0.3886 0.386
Entamoeba histolytica cysteine proteinase, putative 0.0663 0.2123 0.538
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1205 0.3886 1
Echinococcus granulosus cathepsin L 0.0293 0.0921 0.0921
Plasmodium vivax unspecified product 0.037 0.1172 0.2939
Leishmania major cathepsin L-like protease 0.1205 0.3886 1
Brugia malayi Papain family cysteine protease containing protein 0.0293 0.0921 0.0921
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0027 0.0027
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0293 0.0921 0.0921
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1205 0.3886 1
Loa Loa (eye worm) hypothetical protein 0.1205 0.3886 0.3886
Echinococcus granulosus dnaJ subfamily B 0.0481 0.1532 0.1532
Loa Loa (eye worm) transcription factor SMAD2 0.0208 0.0645 0.0645
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1205 0.3886 1
Leishmania major cathepsin L-like protease 0.1205 0.3886 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0087 0.0252 0.0252
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3087 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0031 0.007 0.007
Brugia malayi Papain family cysteine protease containing protein 0.1205 0.3886 0.3886
Echinococcus granulosus cathepsin l cysteine peptidase 0.1205 0.3886 0.3886
Loa Loa (eye worm) hypothetical protein 0.0293 0.0921 0.0921
Echinococcus granulosus smad 0.0014 0.0016 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1205 0.3886 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0663 0.2123 0.538
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1205 0.3886 1
Echinococcus granulosus cathepsin L 0.0663 0.2123 0.2123
Echinococcus granulosus cathepsin L cysteine protease 0.0663 0.2123 0.2123
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0293 0.0921 0.2288
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0031 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0835 0.2684 0.2684
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0027 0.0027
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0027 0.0027
Schistosoma mansoni cathepsin C 0.0293 0.0921 0.0921
Schistosoma mansoni hypothetical protein 0.0481 0.1532 0.1532
Trypanosoma cruzi major cysteine proteinase, putative 0.0293 0.0921 0.0883
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3087 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.037 0.1172 0.1134
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0293 0.0921 0.2288
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0293 0.0921 0.0921
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1205 0.3886 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0027 0.0027
Echinococcus granulosus GPCR family 2 0.0027 0.0059 0.0059
Schistosoma mansoni cpg binding protein 0.0036 0.0086 0.0086
Brugia malayi Papain family cysteine protease containing protein 0.0663 0.2123 0.2123
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.3087 1 1
Entamoeba histolytica cysteine protease, putative 0.0663 0.2123 0.538
Leishmania major cathepsin L-like protease 0.1205 0.3886 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0027 0.0027
Loa Loa (eye worm) papain family cysteine protease containing protein 0.037 0.1172 0.1172
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0293 0.0921 0.0921
Echinococcus multilocularis cathepsin b 0.3087 1 1
Entamoeba histolytica cysteine protease, putative 0.0663 0.2123 0.538
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1205 0.3886 1
Trypanosoma cruzi cysteine protease, putative 0.0663 0.2123 0.209
Loa Loa (eye worm) cysteine protease 0.1205 0.3886 0.3886
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0663 0.2123 0.2123
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0293 0.0921 0.2288
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1205 0.3886 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0014 0.0016 0.0016
Schistosoma mansoni cathepsin F (C01 family) 0.0835 0.2684 0.2684
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0027 0.0059 0.0059
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0027 0.0027
Schistosoma mansoni cathepsin B (C01 family) 0.0293 0.0921 0.0921
Giardia lamblia Cathepsin B precursor 0.1157 0.3729 1
Brugia malayi MH2 domain containing protein 0.0014 0.0016 0.0016
Onchocerca volvulus 0.1205 0.3886 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3087 1 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0031 0.007 0.007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0027 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1205 0.3886 1
Brugia malayi steroid hormone receptor 0.0018 0.0027 0.0027
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1205 0.3886 0.3886
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0027 0.0027
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0293 0.0921 0.0921
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0663 0.2123 0.209
Brugia malayi Cathepsin L-like precursor 0.1205 0.3886 0.3886
Entamoeba histolytica cysteine protease, putative 0.0663 0.2123 0.538
Echinococcus granulosus TGF beta signal transducer SmadC 0.0014 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1205 0.3886 1
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0293 0.0921 0.2288
Onchocerca volvulus 0.1205 0.3886 1
Onchocerca volvulus 0.1205 0.3886 1
Echinococcus multilocularis smad 0.0014 0.0016 0.0016
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0293 0.0921 0.0921
Entamoeba histolytica hypothetical protein 0.0293 0.0921 0.2231
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1205 0.3886 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0293 0.0921 0.0921
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1205 0.3886 1
Brugia malayi Latrophilin receptor protein 2 0.0027 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0293 0.0921 0.0921
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0293 0.0921 0.0921
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0663 0.2123 0.4054
Plasmodium falciparum serine repeat antigen 2 0.0293 0.0921 0.2288
Trypanosoma cruzi cysteine peptidase, putative 0.1205 0.3886 0.386
Schistosoma mansoni cathepsin F (C01 family) 0.1205 0.3886 0.3886
Echinococcus granulosus neuropeptide receptor 0.0216 0.0673 0.0673
Trypanosoma cruzi major cysteine proteinase, putative 0.0293 0.0921 0.0883
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1205 0.3886 1
Brugia malayi Cathepsin L-like precursor 0.1205 0.3886 0.3886
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1205 0.3886 0.3886
Entamoeba histolytica cysteine protease, putative 0.1205 0.3886 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1205 0.3886 1
Leishmania major cathepsin L-like protease 0.1205 0.3886 1
Onchocerca volvulus 0.1205 0.3886 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0293 0.0921 0.0921
Schistosoma mansoni hypothetical protein 0.0059 0.0163 0.0163
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1205 0.3886 1
Entamoeba histolytica cysteine protease, putative 0.0293 0.0921 0.2231
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0027 0.0027
Brugia malayi MH1 domain containing protein 0.0014 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0835 0.2684 0.2684
Brugia malayi Cathepsin L-like precursor 0.0835 0.2684 0.2684
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0031 0.007 0.007
Toxoplasma gondii preprocathepsin c precursor, putative 0.0293 0.0921 0.2288
Onchocerca volvulus Cathepsin L homolog 0.1205 0.3886 1
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0027 0.0027
Toxoplasma gondii cathepsin CPC1 0.0293 0.0921 0.2288
Leishmania major cathepsin L-like protease 0.1205 0.3886 1
Schistosoma mansoni hypothetical protein 0.0027 0.0059 0.0059
Leishmania major cathepsin L-like protease 0.1205 0.3886 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0293 0.0921 0.2288
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0027 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1205 0.3886 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.037 0.1172 0.1172
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0042
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0178 0.0353
Schistosoma mansoni hypothetical protein 0.0146 0.0443 0.0443
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0027 0.0027
Plasmodium falciparum serine repeat antigen 8 0.0293 0.0921 0.2288
Entamoeba histolytica cysteine proteinase, putative 0.0663 0.2123 0.538
Brugia malayi Cathepsin L-like precursor 0.0835 0.2684 0.2684
Brugia malayi hypothetical protein 0.0031 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.037 0.1172 0.1172
Entamoeba histolytica cysteine protease, putative 0.0293 0.0921 0.2231
Toxoplasma gondii cathepsin CPL 0.1205 0.3886 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1157 0.3729 0.9593
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0027 0.0027
Loa Loa (eye worm) MH2 domain-containing protein 0.0208 0.0645 0.0645
Entamoeba histolytica cysteine protease, putative 0.0293 0.0921 0.2231
Brugia malayi MH2 domain containing protein 0.0014 0.0016 0.0016
Trypanosoma brucei cysteine peptidase C (CPC) 0.1157 0.3729 0.9593
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1205 0.3886 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1205 0.3886 1
Brugia malayi Cathepsin L-like precursor 0.1205 0.3886 0.3886
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1205 0.3886 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0663 0.2123 0.2123
Echinococcus granulosus cysteine protease 0.0663 0.2123 0.2123
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0027 0.0027
Loa Loa (eye worm) fibroinase 0.1205 0.3886 0.3886
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0146 0.0443 0.0443
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0293 0.0921 0.0921
Loa Loa (eye worm) hypothetical protein 0.0293 0.0921 0.0921
Loa Loa (eye worm) MH1 domain-containing protein 0.0014 0.0016 0.0016
Entamoeba histolytica cysteine protease, putative 0.0663 0.2123 0.538
Trypanosoma cruzi cysteine proteinase, putative 0.0663 0.2123 0.209
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0293 0.0921 0.2288
Echinococcus multilocularis cpg binding protein 0.0036 0.0086 0.0086
Echinococcus multilocularis mothers against decapentaplegic 5 0.0014 0.0016 0.0016
Schistosoma mansoni cpg binding protein 0.0034 0.008 0.008
Entamoeba histolytica cysteine protease, putative 0.0663 0.2123 0.538
Entamoeba histolytica cysteine protease, putative 0.0663 0.2123 0.538
Echinococcus multilocularis G protein coupled receptor 139 0.0216 0.0673 0.0673
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0663 0.2123 0.5414
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0027 0.0027
Schistosoma mansoni smad1 5 8 and 0.0014 0.0016 0.0016
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0027 0.0027
Echinococcus multilocularis cathepsin b 0.3087 1 1
Echinococcus multilocularis GPCR, family 2 0.0027 0.0059 0.0059
Leishmania major cysteine peptidase A (CPA) 0.1205 0.3886 1
Loa Loa (eye worm) hypothetical protein 0.3087 1 1
Onchocerca volvulus Cathepsin L homolog 0.1205 0.3886 1
Loa Loa (eye worm) hypothetical protein 0.0293 0.0921 0.0921
Trypanosoma cruzi cysteine peptidase, putative 0.037 0.1172 0.1134
Loa Loa (eye worm) hypothetical protein 0.037 0.1172 0.1172
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0293 0.0921 0.0921
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0027 0.0027
Onchocerca volvulus 0.0293 0.0921 0.2318
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1205 0.3886 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0293 0.0921 0.0921
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0014 0.0016 0.0016
Plasmodium vivax vivapain-2 0.1205 0.3886 1
Onchocerca volvulus 0.1205 0.3886 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1205 0.3886 1
Plasmodium falciparum serine repeat antigen 7 0.0293 0.0921 0.2288
Entamoeba histolytica cysteine protease, putative 0.0663 0.2123 0.538
Brugia malayi Papain family cysteine protease containing protein 0.0663 0.2123 0.2123
Brugia malayi cathepsin L-like precursor 0.0835 0.2684 0.2684

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) > 200 mg kg-1 Antiwrithing activity in po dosed mouse assessed as prevention of phenyl-p-benzoquinone-induced abdominal constriction response ChEMBL. 31481

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.