TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 240.279 | Formula: C10H12N2O3S
H donors: 1 H acceptors: 2 LogP: 3.12 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)N/C(=C\[N+](=O)[O-])/SC
InChi: 1S/C10H12N2O3S/c1-15-9-5-3-8(4-6-9)11-10(16-2)7-12(13)14/h3-7,11H,1-2H3/b10-7+
InChiKey: KTGOPTAYWAHLCN-JXMROGBWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	thioredoxin reductase	0.0103	0.0425	0.9925
Brugia malayi	Thioredoxin reductase	0.0103	0.0425	0.039
Schistosoma mansoni	serine/threonine protein kinase	0.0103	0.0428	0.086
Giardia lamblia	Kinase, STE STE20	0.0157	0.0736	1
Onchocerca volvulus		0.0059	0.0178	0.5
Plasmodium vivax	protein kinase Crk2	0.0103	0.0428	1
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0103	0.0428	0.0393
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0073	0.0257	0.1676
Plasmodium falciparum	glutathione reductase	0.0036	0.0042	0.0116
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0036	0.0042	0.5
Brugia malayi	P21-Rho-binding domain containing protein	0.0152	0.0705	0.0672
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0036	0.0042	0.0116
Trichomonas vaginalis	CMGC family protein kinase	0.0103	0.0428	0.5812
Echinococcus multilocularis	calcium activated potassium channel	0.004	0.0067	0.0034
Trichomonas vaginalis	STE family protein kinase	0.0157	0.0736	1
Schistosoma mansoni	hypothetical protein	0.0152	0.0705	0.147
Echinococcus multilocularis	p21 activated protein kinase 1 Dpak1	0.0157	0.0736	0.0769
Echinococcus granulosus	serine:threonine protein kinase PAK 3	0.0157	0.0736	0.0768
Echinococcus granulosus	cyclin dependent kinase	0.0103	0.0428	0.0429
Toxoplasma gondii	aldehyde dehydrogenase	0.0073	0.0257	0.5623
Echinococcus granulosus	serine:threonine protein kinase	0.0051	0.0131	0.0103
Schistosoma mansoni	protein kinase	0.0157	0.0736	0.1538
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0036	0.0042	0.0116
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0036	0.0042	0.0983
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0036	0.0042	0.5
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0073	0.0257	0.0241
Schistosoma mansoni	serine/threonine protein kinase	0.0086	0.0328	0.0642
Trypanosoma brucei	cdc2-related kinase 1	0.0103	0.0428	1
Plasmodium vivax	glutathione reductase, putative	0.0103	0.0425	0.9925
Schistosoma mansoni	protein kinase	0.0157	0.0736	0.1538
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0103	0.0428	0.0393
Echinococcus multilocularis	cyclin dependent kinase 1	0.0103	0.0428	0.043
Echinococcus granulosus	cyclin dependent kinase 1	0.0103	0.0428	0.0429
Schistosoma mansoni	protein kinase	0.0157	0.0736	0.1538
Mycobacterium tuberculosis	Probable oxidoreductase	0.0261	0.1324	1
Giardia lamblia	Kinase, CMGC CDK	0.0103	0.0428	0.5558
Entamoeba histolytica	protein kinase, putative	0.0157	0.0736	1
Entamoeba histolytica	hypothetical protein	0.0152	0.0705	0.9585
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0073	0.0257	0.6007
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0257	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0131	0.0095
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0036	0.0042	0.0983
Brugia malayi	Protein kinase domain containing protein	0.0103	0.0428	0.0393
Trichomonas vaginalis	STE family protein kinase	0.0157	0.0736	1
Echinococcus granulosus	neural Wiskott Aldrich syndrome protein	0.0152	0.0705	0.0734
Echinococcus granulosus	protein kinase shaggy	0.0059	0.0178	0.0154
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0036	0.0042	0.0116
Brugia malayi	Importin beta-1 subunit	0.0035	0.0038	0.0001
Echinococcus granulosus	calcium activated potassium channel	0.004	0.0067	0.0032
Mycobacterium tuberculosis	Probable dehydrogenase	0.0234	0.1175	0.8837
Schistosoma mansoni	hypothetical protein	0.0152	0.0705	0.147
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0036	0.0042	0.5
Echinococcus multilocularis	serine:threonine protein kinase MARK2	0.0086	0.0328	0.0321
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0036	0.0042	0.0983
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0036	0.0042	0.0983
Brugia malayi	Protein kinase domain containing protein	0.004	0.0067	0.0031
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0059	0.0178	0.36
Entamoeba histolytica	protein kinase domain containing protein	0.0059	0.0178	0.2419
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0036	0.0042	0.0007
Trichomonas vaginalis	CMGC family protein kinase	0.0103	0.0428	0.5812
Trypanosoma brucei	protein kinase, putative	0.0059	0.0178	0.36
Echinococcus granulosus	microtubule associated protein 2	0.0833	0.4587	0.5001
Trypanosoma brucei	protein kinase, putative	0.0063	0.0197	0.4082
Echinococcus granulosus	serine:threonine protein kinase PAK 4	0.1631	0.9134	1
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0063	0.0197	0.4082
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0063	0.0197	0.4601
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0059	0.0178	0.0312
Echinococcus multilocularis	cyclin dependent kinase 1	0.0103	0.0428	0.043
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0234	0.1175	0.8837
Echinococcus granulosus	serine:threonine protein kinase	0.0051	0.0131	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0397	0.0362
Echinococcus multilocularis	serine:threonine protein kinase PAK 3	0.0157	0.0736	0.0769
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0257	1
Echinococcus granulosus	mitogen activated protein kinase 3	0.0063	0.0197	0.0175
Echinococcus multilocularis	cyclin dependent kinase	0.0103	0.0428	0.043
Trichomonas vaginalis	STE family protein kinase	0.0157	0.0736	1
Entamoeba histolytica	protein kinase, putative	0.0157	0.0736	1
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0131	0.0095
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0059	0.0178	0.0156
Echinococcus multilocularis	serine:threonine protein kinase MARK2	0.0086	0.0328	0.0321
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0036	0.0042	0.0983
Mycobacterium tuberculosis	Probable reductase	0.0234	0.1175	0.8837
Echinococcus multilocularis	serine:threonine protein kinase PAK 4	0.1631	0.9134	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0036	0.0042	0.0983
Echinococcus multilocularis	geminin	0.0205	0.1005	0.1065
Trichomonas vaginalis	CMGC family protein kinase	0.0063	0.0197	0.2674
Loa Loa (eye worm)	STE/STE20/PAKB protein kinase	0.1784	1	1
Loa Loa (eye worm)	CAMK/CAMKL/MELK protein kinase	0.004	0.0067	0.0031
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0103	0.0428	1
Trypanosoma cruzi	cdc2-related kinase 1	0.0103	0.0428	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0036	0.0042	0.0983
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0036	0.0042	0.0983
Trypanosoma cruzi	cdc2-related kinase 1	0.0103	0.0428	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0036	0.0042	0.0983
Trypanosoma brucei	cdc2-related kinase 3	0.0103	0.0428	1
Trichomonas vaginalis	conserved hypothetical protein	0.0152	0.0705	0.9585
Trypanosoma cruzi	cdc2-related kinase 3	0.0103	0.0428	1
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0059	0.0178	0.0142
Trichomonas vaginalis	mercuric reductase, putative	0.0036	0.0042	0.0572
Trichomonas vaginalis	STE family protein kinase	0.0157	0.0736	1
Entamoeba histolytica	protein kinase, putative	0.0059	0.0178	0.2419
Echinococcus granulosus	p21 activated protein kinase 1 Dpak1	0.0157	0.0736	0.0768
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.0178	0.2419
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0257	0.0485
Schistosoma mansoni	serine/threonine protein kinase	0.004	0.0067	0.0067
Schistosoma mansoni	wiskott-aldrich syndrome protein	0.0152	0.0705	0.147
Schistosoma mansoni	serine/threonine protein kinase	0.004	0.0067	0.0067
Entamoeba histolytica	protein kinase, putative	0.0157	0.0736	1
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0103	0.0428	0.0429
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0234	0.1175	0.8837
Schistosoma mansoni	serine/threonine protein kinase	0.0086	0.0328	0.0642
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0059	0.0178	0.0142
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0036	0.0042	0.0006
Brugia malayi	MAP kinase sur-1	0.0063	0.0197	0.0161
Giardia lamblia	Kinase, CMGC MAPK	0.0063	0.0197	0.223
Echinococcus granulosus	thioredoxin glutathione reductase	0.0103	0.0428	0.0429
Echinococcus multilocularis	serine:threonine protein kinase	0.0051	0.0131	0.0104
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.0178	0.2419
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0103	0.0428	1
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0103	0.0428	1
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0036	0.0042	0.0013
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0036	0.0042	0.0116
Treponema pallidum	NADH oxidase	0.0036	0.0042	0.5
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0257	1
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0103	0.0428	0.0393
Schistosoma mansoni	serine/threonine protein kinase	0.0103	0.0428	0.086
Brugia malayi	RNA, U transporter 1	0.0099	0.0403	0.0369
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0261	0.1324	1
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0063	0.0197	0.4601
Echinococcus multilocularis	cyclin dependent kinase 5	0.0103	0.0428	0.043
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0063	0.0197	0.0161
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0059	0.0178	0.4162
Echinococcus granulosus	serine:threonine protein kinase MARK2	0.0086	0.0328	0.0319
Schistosoma mansoni	tyrosine kinase	0.0152	0.0705	0.147
Loa Loa (eye worm)	CAMK/CAMKL/MARK protein kinase	0.0051	0.0131	0.0095
Giardia lamblia	Kinase, CMGC GSK	0.0059	0.0178	0.1959
Echinococcus granulosus	mitogen activated protein kinase	0.0063	0.0197	0.0175
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0036	0.0042	0.0116
Schistosoma mansoni	serine/threonine protein kinase	0.004	0.0067	0.0067
Schistosoma mansoni	hypothetical protein	0.0205	0.1005	0.2129
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0036	0.0042	0.0983
Entamoeba histolytica	cell division protein kinase 2, putative	0.0103	0.0428	0.5812
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0261	0.1324	1
Trichomonas vaginalis	CMGC family protein kinase	0.0103	0.0428	0.5812
Trichomonas vaginalis	CAMK family protein kinase	0.0051	0.0131	0.1782
Entamoeba histolytica	protein kinase domain containing protein	0.0059	0.0178	0.2419
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0063	0.0197	0.4601
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0372	0.1957	0.1928
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0063	0.0197	0.0177
Echinococcus multilocularis	PAK box P21 Rho binding	0.0157	0.0736	0.0769
Entamoeba histolytica	protein kinase, putative	0.0157	0.0736	1
Plasmodium vivax	thioredoxin reductase, putative	0.0103	0.0425	0.9925
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0036	0.0042	0.0983
Brugia malayi	P21-Rho-binding domain containing protein	0.0152	0.0705	0.0672
Plasmodium falciparum	thioredoxin reductase	0.0036	0.0042	0.0116
Leishmania major	trypanothione reductase	0.0103	0.0425	0.9932
Brugia malayi	intracellular kinase	0.0059	0.0178	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0152	0.0705	0.0672
Schistosoma mansoni	hypothetical protein	0.0152	0.0705	0.147
Giardia lamblia	Kinase, CMGC CDK	0.0103	0.0428	0.5558
Entamoeba histolytica	cell division protein kinase 2, putative	0.0103	0.0428	0.5812
Plasmodium falciparum	glutathione reductase	0.0103	0.0425	0.9925
Schistosoma mansoni	serine/threonine protein kinase	0.0152	0.0705	0.147
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0059	0.0178	0.0154
Trichomonas vaginalis	STE family protein kinase	0.0157	0.0736	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0103	0.0425	0.2985
Echinococcus granulosus	serine:threonine protein kinase PAK 3	0.0157	0.0736	0.0768
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0257	0.0485
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0261	0.1324	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0103	0.0425	0.9932
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0036	0.0042	0.0983
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0036	0.0042	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0063	0.0197	0.0353
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0073	0.0257	0.0243
Loa Loa (eye worm)	P21-Rho-binding domain-containing protein	0.0152	0.0705	0.0672
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0234	0.1175	0.8837
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0063	0.0197	0.4601
Schistosoma mansoni	hypothetical protein	0.0205	0.1005	0.2129
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0059	0.0178	0.36
Echinococcus granulosus	snurportin 1	0.0372	0.1957	0.211
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0063	0.0197	0.4601
Brugia malayi	cell division control protein 2 homolog	0.0103	0.0428	0.0393
Schistosoma mansoni	microtubule-associated protein tau	0.0833	0.4587	1
Plasmodium falciparum	thioredoxin reductase	0.0103	0.0425	0.9925
Schistosoma mansoni	serine/threonine kinase	0.004	0.0067	0.0067
Giardia lamblia	Kinase, CMGC GSK	0.0059	0.0178	0.1959
Echinococcus multilocularis	serine:threonine protein kinase	0.0051	0.0131	0.0104
Echinococcus multilocularis	snurportin 1	0.0372	0.1957	0.2111
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0036	0.0042	0.0116
Echinococcus granulosus	PAK box P21 Rho binding	0.0152	0.0705	0.0734
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0059	0.0178	0.4162
Entamoeba histolytica	p21-activated kinase	0.0157	0.0736	1
Echinococcus granulosus	geminin	0.0205	0.1005	0.1064
Trichomonas vaginalis	CMGC family protein kinase	0.0063	0.0197	0.2674
Brugia malayi	WH1 domain containing protein	0.0152	0.0705	0.0672
Echinococcus granulosus	serine:threonine protein kinase MARK2	0.0086	0.0328	0.0319
Schistosoma mansoni	importin beta-1	0.0035	0.0038	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0038	0.0001
Echinococcus multilocularis	protein kinase shaggy	0.0059	0.0178	0.0156
Schistosoma mansoni	hypothetical protein	0.0372	0.1957	0.4221
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0063	0.0197	0.4082
Entamoeba histolytica	hypothetical protein	0.0152	0.0705	0.9585
Echinococcus multilocularis	mitogen activated protein kinase	0.0063	0.0197	0.0177
Brugia malayi	glutathione reductase	0.0103	0.0425	0.039
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0036	0.0042	0.0983
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0036	0.0042	0.0116
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0063	0.0197	0.4601
Brugia malayi	Protein kinase domain	0.0157	0.0736	0.0702
Trypanosoma brucei	trypanothione reductase	0.0103	0.0425	0.9925
Trypanosoma cruzi	cdc2-related kinase 3	0.0103	0.0428	1
Echinococcus multilocularis	microtubule associated protein 2	0.0833	0.4587	0.5002
Toxoplasma gondii	NADPH-glutathione reductase	0.0036	0.0042	0.0116
Echinococcus granulosus	3'partial\|serine:threonine protein kinase PAK 2	0.0152	0.0705	0.0734
Echinococcus multilocularis	importin subunit beta 1	0.0035	0.0038	0.0002
Echinococcus multilocularis	serine:threonine protein kinase PAK 3	0.0157	0.0736	0.0769
Trichomonas vaginalis	CAMK family protein kinase	0.004	0.0067	0.0905
Trichomonas vaginalis	CMGC family protein kinase	0.0063	0.0197	0.2674
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0234	0.1175	0.8837
Trichomonas vaginalis	glutathione reductase, putative	0.0036	0.0042	0.0572
Echinococcus multilocularis	PAK box P21 Rho binding	0.0152	0.0705	0.0736
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0103	0.0428	0.0431
Loa Loa (eye worm)	glutathione reductase	0.0103	0.0425	0.039
Trichomonas vaginalis	CMGC family protein kinase	0.0063	0.0197	0.2674
Plasmodium falciparum	protein kinase 5	0.0103	0.0428	1
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0036	0.0042	0.0116
Plasmodium falciparum	glycogen synthase kinase 3	0.0059	0.0178	0.36
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0036	0.0042	0.0116
Schistosoma mansoni	protein kinase	0.0152	0.0705	0.147
Echinococcus multilocularis	neural Wiskott Aldrich syndrome protein	0.0152	0.0705	0.0736
Loa Loa (eye worm)	thioredoxin reductase	0.0103	0.0425	0.039
Echinococcus granulosus	cyclin dependent kinase 5	0.0103	0.0428	0.0429

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 39 uM	Antitrypanosomal activity against epimastigote stage of Trypanosoma cruzi Y after 96 hrs by hemocytometry	ChEMBL.	25461316

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3397112

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1922992