Detailed information for compound 2018445

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 644.765 | Formula: C44H32N6
  • H donors: 4 H acceptors: 2 LogP: 9.05 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 2
  • SMILES: Nc1ccc(cc1)/C/1=C\2/C=CC(=N2)/C(=c\2/cc/c(=C(/C3=N/C(=C(/c4[nH]c1cc4)\c1ccccc1)/C=C3)\c1ccc(cc1)N)/[nH]2)/c1ccccc1
  • InChi: 1S/C44H32N6/c45-31-15-11-29(12-16-31)43-37-23-19-33(47-37)41(27-7-3-1-4-8-27)34-20-24-38(48-34)44(30-13-17-32(46)18-14-30)40-26-22-36(50-40)42(28-9-5-2-6-10-28)35-21-25-39(43)49-35/h1-26,47,50H,45-46H2/b41-33-,41-34-,42-35-,42-36-,43-37-,43-39-,44-38-,44-40-
  • InChiKey: FNUGBWUULHWQCC-VRDUDMDPSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum thioredoxin reductase 0.0016 0.0004 0.0006
Echinococcus multilocularis cysteine protease 0.0016 0.0007 0.0007
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0071 0.0104
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0364 0.0529
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0364 0.0529
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0154 0.0161
Brugia malayi Matrixin family protein 0.0043 0.0213 0.0213
Onchocerca volvulus 0.0035 0.0153 0.0314
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0611 0.4658 0.4658
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0107 0.0111
Echinococcus multilocularis allatostatin A receptor 0.0611 0.4658 0.4854
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.0007
Echinococcus granulosus dnaJ subfamily B 0.1242 0.9597 1
Brugia malayi EGF-like domain containing protein 0.003 0.0115 0.0115
Brugia malayi Integrin alpha pat-2 precursor 0.0152 0.1068 0.1068
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0004 0.0006
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0186 0.0193
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0025 0.0073 0.0076
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0007 0.0007
Schistosoma mansoni rab6-interacting 0.0019 0.003 0.0031
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0071
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0154 0.0154
Leishmania major beta tubulin 0.0894 0.6875 1
Echinococcus granulosus FMRFamide activated amiloride sensitive sodium 0.0178 0.1274 0.1328
Onchocerca volvulus 0.0611 0.4658 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0611 0.4658 0.4658
Onchocerca volvulus Matrilysin homolog 0.0094 0.0618 0.1314
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0092 0.0599 0.0624
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Leishmania major beta tubulin 0.0894 0.6875 1
Echinococcus multilocularis beta tubulin 0.0894 0.6875 0.7163
Loa Loa (eye worm) tubulin beta chain 0.0894 0.6875 0.6875
Loa Loa (eye worm) hypothetical protein 0.0043 0.0213 0.0213
Toxoplasma gondii beta-1 tubulin, putative 0.0894 0.6875 1
Brugia malayi hypothetical protein 0.0611 0.4658 0.4658
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0029 0.0109 0.0152
Giardia lamblia Beta tubulin 0.0894 0.6875 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0115 0.0115
Plasmodium vivax glutathione reductase, putative 0.0046 0.0239 0.0347
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Entamoeba histolytica protein kinase, putative 0.0033 0.0141 0.0194
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0611 0.4658 0.4854
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0364 0.0529
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0071 0.0104
Echinococcus multilocularis integrin alpha ps 0.0068 0.0413 0.043
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Entamoeba histolytica tubulin family protein 0.0894 0.6875 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0698 0.8844
Echinococcus granulosus protein vprbp 0.0178 0.1274 0.1328
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Echinococcus granulosus neuropeptide Y receptor 0.0611 0.4658 0.4854
Loa Loa (eye worm) BEN-1 protein 0.0894 0.6875 0.6875
Entamoeba histolytica hypothetical protein 0.0035 0.0153 0.0212
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0186 0.0193
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0344 0.0359
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0258 0.0258
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.016 0.0226
Schistosoma mansoni biogenic amine receptor 0.0611 0.4658 0.4854
Echinococcus multilocularis fibrillin 1 0.003 0.0115 0.012
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0004 0.5
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0109 0.0152
Onchocerca volvulus 0.0047 0.0246 0.0514
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0239 0.0347
Toxoplasma gondii beta tubulin 0.0894 0.6875 1
Echinococcus multilocularis dna polymerase eta 0.0033 0.0141 0.0147
Echinococcus granulosus dna polymerase kappa 0.006 0.0352 0.0367
Echinococcus granulosus neuropeptide Y receptor 0.0611 0.4658 0.4854
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Schistosoma mansoni hypothetical protein 0.0178 0.1274 0.1328
Brugia malayi Tyrosine-protein kinase abl-1 0.0106 0.0712 0.0712
Echinococcus granulosus rhodopsin orphan GPCR 0.0611 0.4658 0.4854
Brugia malayi ORL1-like opioid receptor 0.0611 0.4658 0.4658
Toxoplasma gondii hypothetical protein 0.003 0.0115 0.0168
Onchocerca volvulus 0.0611 0.4658 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0172 0.0251
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0344 0.9772
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0006
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0194 0.0282
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0611 0.4658 0.4854
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0698 0.8844
Echinococcus granulosus tm gpcr rhodopsin 0.0611 0.4658 0.4854
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0087 0.0562 0.0585
Schistosoma mansoni amiloride-sensitive sodium channel-related 0.0178 0.1274 0.1328
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Echinococcus multilocularis integrin alpha 3 0.0116 0.079 0.0824
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0611 0.4658 0.4854
Loa Loa (eye worm) tubulin beta-4 chain 0.0894 0.6875 0.6875
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Loa Loa (eye worm) hypothetical protein 0.0043 0.0213 0.0213
Trichomonas vaginalis DNA polymerase eta, putative 0.006 0.0352 0.0506
Echinococcus granulosus tyrosine protein kinase Fyn 0.0055 0.0309 0.0322
Schistosoma mansoni hypothetical protein 0.0611 0.4658 0.4854
Brugia malayi Matrixin family protein 0.0103 0.0685 0.0685
Loa Loa (eye worm) G-protein coupled receptor 0.0611 0.4658 0.4658
Schistosoma mansoni terminal deoxycytidyl transferase 0.0033 0.0141 0.0147
Trypanosoma brucei beta tubulin 0.0894 0.6875 1
Brugia malayi celfurPC protein 0.0122 0.0834 0.0834
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Echinococcus granulosus FMRFamide activated amiloride sensitive sodium 0.0178 0.1274 0.1328
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0611 0.4658 0.4854
Trichomonas vaginalis hypothetical protein 0.0029 0.0109 0.0152
Echinococcus multilocularis FMRFamide activated amiloride sensitive sodium 0.0178 0.1274 0.1328
Echinococcus multilocularis G-protein coupled receptor, putative 0.0611 0.4658 0.4854
Echinococcus granulosus tyrosine kinase 0.0044 0.0226 0.0235
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0611 0.4658 0.4854
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0004 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0611 0.4658 0.4854
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0109 0.0152
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.003
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.1458 0.1458
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Onchocerca volvulus 0.0611 0.4658 1
Loa Loa (eye worm) neuropeptide F receptor 0.0611 0.4658 0.4658
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0004
Schistosoma mansoni amine GPCR 0.0611 0.4658 0.4854
Leishmania major beta tubulin 0.0894 0.6875 1
Echinococcus multilocularis cysteine protease 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Loa Loa (eye worm) TK protein kinase 0.0044 0.0226 0.0226
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0611 0.4658 0.4854
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0698 0.8844
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0326 0.034
Loa Loa (eye worm) hypothetical protein 0.0178 0.1274 0.1274
Echinococcus granulosus sodium channel nonvoltage gated 1 alpha 0.0178 0.1274 0.1328
Echinococcus multilocularis fibrillin 2 0.003 0.0115 0.012
Echinococcus multilocularis growth factor receptor bound protein 2 0.0022 0.0049 0.0051
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Loa Loa (eye worm) amiloride-sensitive sodium channel 0.0178 0.1274 0.1274
Schistosoma mansoni amine GPCR 0.0611 0.4658 0.4854
Brugia malayi PAS domain containing protein 0.0047 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Onchocerca volvulus 0.0098 0.0648 0.1378
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0364 0.0529
Brugia malayi RE15519p 0.0611 0.4658 0.4658
Schistosoma mansoni nck2/grb4 0.0022 0.0049 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0004
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0611 0.4658 0.4658
Schistosoma mansoni alpha-1 adrenergic receptor 0.0611 0.4658 0.4854
Onchocerca volvulus Neuropeptide F receptor homolog 0.0611 0.4658 1
Echinococcus granulosus dro:myosuppressin receptor 0.0611 0.4658 0.4854
Echinococcus granulosus tyrosine protein kinase csk 0.0036 0.0161 0.0168
Trichomonas vaginalis tubulin beta chain, putative 0.0894 0.6875 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0611 0.4658 0.4658
Loa Loa (eye worm) integrin alpha pat-2 0.0234 0.171 0.171
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0611 0.4658 0.4854
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0004
Echinococcus granulosus tyrosine protein kinase Fyn 0.0055 0.0309 0.0322
Echinococcus multilocularis tyrosine protein kinase csk 0.0036 0.0161 0.0168
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0611 0.4658 0.4854
Echinococcus multilocularis Tubulin beta 2C chain 0.0894 0.6875 0.7163
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0007 0.0007
Echinococcus granulosus amiloride sensitive cation channel 4 A 0.0178 0.1274 0.1328
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0017 0.0014 0.002
Loa Loa (eye worm) hypothetical protein 0.0043 0.0213 0.0213
Schistosoma mansoni hypothetical protein 0.006 0.0352 0.0367
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0141 0.1791
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0007 0.001
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0025 0.0073 0.0076
Leishmania major beta tubulin 0.0894 0.6875 1
Brugia malayi amiloride-sensitive sodium channel alpha-subunit, putative 0.0178 0.1274 0.1274
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0114 0.0774 0.0807
Echinococcus multilocularis rhodopsin orphan GPCR 0.0611 0.4658 0.4854
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0025 0.0073 0.0076
Brugia malayi beta-tubulin, identical 0.0894 0.6875 0.6875
Brugia malayi hypothetical protein 0.0611 0.4658 0.4658
Toxoplasma gondii thioredoxin reductase 0.0046 0.0239 0.0347
Loa Loa (eye worm) degenerin unc-8 0.0178 0.1274 0.1274
Treponema pallidum NADH oxidase 0.0016 0.0004 0.5
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0043 0.0213 0.0222
Brugia malayi AKH receptor 0.0611 0.4658 0.4658
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0007 0.0007
Echinococcus granulosus neuropeptide receptor A26 0.1057 0.8146 0.8488
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0341 0.0355
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0611 0.4658 0.4658
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0007 0.0007
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.003 0.0031
Echinococcus multilocularis g protein coupled receptor 0.0611 0.4658 0.4854
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0087 0.0562 0.0585
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0344 0.0501
Brugia malayi Serotonin receptor 0.0611 0.4658 0.4658
Echinococcus multilocularis sex peptide receptor 0.0611 0.4658 0.4854
Loa Loa (eye worm) hypothetical protein 0.0033 0.0141 0.0141
Brugia malayi Kelch motif family protein 0.0198 0.1432 0.1432
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0078 0.0113
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0611 0.4658 0.4658
Leishmania major beta tubulin 0.0894 0.6875 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0352 0.0512
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0092 0.0599 0.0866
Echinococcus multilocularis g-protein coupled receptor 0.0611 0.4658 0.4854
Giardia lamblia DINP protein human, muc B family 0.004 0.0194 0.0275
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0141 0.0141
Leishmania major cathepsin L-like protease 0.0016 0.0007 0.001
Brugia malayi larval opioid receptor 0.0611 0.4658 0.4658
Echinococcus multilocularis protein jagged 2 0.003 0.0115 0.012
Schistosoma mansoni hypothetical protein 0.0611 0.4658 0.4854
Echinococcus granulosus sex peptide receptor 0.0611 0.4658 0.4854
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0611 0.4658 1
Loa Loa (eye worm) hypothetical protein 0.0839 0.6444 0.6444
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0006
Schistosoma mansoni tyrosine kinase 0.0057 0.033 0.0343
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0154 0.0218
Echinococcus multilocularis FMRFamide activated amiloride sensitive sodium 0.0178 0.1274 0.1328
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.1022 0.1022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0611 0.4658 0.4854
Echinococcus granulosus integrin alpha ps 0.0068 0.0413 0.043
Brugia malayi Variant SH3 domain containing protein 0.0022 0.0049 0.0049
Giardia lamblia Tenascin-like 0.003 0.0115 0.0161
Leishmania major beta tubulin 0.0894 0.6875 1
Onchocerca volvulus Matrilysin homolog 0.0043 0.0213 0.0443
Loa Loa (eye worm) hypothetical protein 0.0052 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Echinococcus multilocularis rhodopsin orphan GPCR 0.0611 0.4658 0.4854
Echinococcus multilocularis Na+ channel, amiloride sensitive 0.0178 0.1274 0.1328
Echinococcus granulosus G protein coupled receptor 139 0.0611 0.4658 0.4854
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0087 0.0562 0.0585
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.0322 0.0468
Echinococcus granulosus beta tubulin 0.0894 0.6875 0.7163
Brugia malayi SH2 domain containing protein 0.0047 0.0246 0.0246
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0611 0.4658 0.4854
Echinococcus granulosus neuropeptide receptor 0.0611 0.4658 0.4854
Echinococcus multilocularis neuropeptide Y receptor 0.0611 0.4658 0.4854
Loa Loa (eye worm) matrixin family protein 0.0103 0.0685 0.0685
Plasmodium falciparum glutathione reductase 0.0046 0.0239 0.0347
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0611 0.4658 0.4854
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0087 0.0562 0.0585
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0004
Giardia lamblia Tenascin-37 0.003 0.0115 0.0161
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0078 0.0113
Brugia malayi hypothetical protein 0.0611 0.4658 0.4658
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Onchocerca volvulus 0.0019 0.003 0.0048
Brugia malayi Dopamine receptor 0.0611 0.4658 0.4658
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0004
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0071 0.0104
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0344 0.0344
Echinococcus granulosus RUN 0.0019 0.003 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0004
Echinococcus granulosus Tubulin beta 2C chain 0.0894 0.6875 0.7163
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0154 0.0224
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0004 0.0006
Echinococcus multilocularis tubulin subunit beta 0.0894 0.6875 0.7163
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0007 0.001
Brugia malayi Tyrosine-protein kinase abl-1 0.0132 0.0913 0.0913
Schistosoma mansoni growth hormone secretagogue receptor 0.0611 0.4658 0.4854
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0344 0.9772
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0055 0.0309 0.0322
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0239 0.0347
Schistosoma mansoni amine GPCR 0.0611 0.4658 0.4854
Schistosoma mansoni hypothetical protein 0.0178 0.1274 0.1328
Echinococcus granulosus FMRFamide activated amiloride sensitive sodium 0.0178 0.1274 0.1328
Echinococcus multilocularis rhodopsin orphan GPCR 0.0611 0.4658 0.4854
Leishmania major beta tubulin 0.0894 0.6875 1
Loa Loa (eye worm) fibroinase 0.0016 0.0007 0.0007
Echinococcus granulosus g protein coupled receptor 0.0611 0.4658 0.4854
Loa Loa (eye worm) hypothetical protein 0.0033 0.0135 0.0135
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0364 0.0529
Schistosoma mansoni amiloride-sensitive sodium channel-related 0.0178 0.1274 0.1328
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0611 0.4658 0.4658
Echinococcus granulosus Tubulin beta 2C chain 0.0894 0.6875 0.7163
Brugia malayi Doublecortin family protein 0.0019 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0178 0.1274 0.1328
Echinococcus granulosus growth factor receptor bound protein 2 0.0022 0.0049 0.0051
Echinococcus multilocularis rhodopsin orphan GPCR 0.0611 0.4658 0.4854
Brugia malayi Degenerin-like protein ZK770.1 in chromosome I, putative 0.0178 0.1274 0.1274
Leishmania major beta tubulin 0.0894 0.6875 1
Echinococcus multilocularis amiloride sensitive cation channel acid sensing ion channel pituitary 0.0178 0.1274 0.1328
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Onchocerca volvulus 0.0611 0.4658 1
Trichomonas vaginalis hypothetical protein 0.003 0.0115 0.0161
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Schistosoma mansoni alpha-glucosidase 0.0136 0.0943 0.0983
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.0007
Echinococcus multilocularis orexin receptor type 2 0.0611 0.4658 0.4854
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0151 0.1063 0.1108
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0113 0.0164
Schistosoma mansoni hypothetical protein 0.0029 0.0109 0.0114
Echinococcus multilocularis Tubulin beta 2C chain 0.0894 0.6875 0.7163
Schistosoma mansoni tubulin subunit beta 0.0894 0.6875 0.7163
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0611 0.4658 0.4854
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0041 0.0202 0.021
Echinococcus granulosus Na channel amiloride sensitive 0.0178 0.1274 0.1328
Brugia malayi hypothetical protein 0.0611 0.4658 0.4658
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0092 0.0599 0.0624
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0007 0.0007
Schistosoma mansoni biogenic amine (5HT) receptor 0.0611 0.4658 0.4854
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0154 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0109 0.0152
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0894 0.6875 0.7163
Loa Loa (eye worm) hypothetical protein 0.003 0.0115 0.0115
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.016 0.016
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0611 0.4658 0.4854
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0249 0.0259
Onchocerca volvulus 0.023 0.1677 0.359
Brugia malayi Degenerin-like protein C41C4.5 in chromosome II, putative 0.0178 0.1274 0.1274
Schistosoma mansoni opsin-like receptor 0.0611 0.4658 0.4854
Schistosoma mansoni opsin-like receptor 0.0611 0.4658 0.4854
Echinococcus multilocularis neuropeptide receptor 0.0611 0.4658 0.4854
Echinococcus multilocularis tyrosine protein kinase csk 0.0036 0.0161 0.0168
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Schistosoma mansoni lipoxygenase 0.008 0.0505 0.0526
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Brugia malayi hypothetical protein 0.0118 0.0803 0.0803
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0004
Echinococcus granulosus tyrosine protein kinase ABL1 0.0228 0.1661 0.1731
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0611 0.4658 0.4854
Schistosoma mansoni histamine h1 receptor 0.0611 0.4658 0.4854
Leishmania major trypanothione reductase 0.0046 0.0239 0.0347
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0611 0.4658 0.4854
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0004 0.0004
Schistosoma mansoni tubulin subunit beta 0.0894 0.6875 0.7163
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0004 0.0006
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0239 0.3025
Echinococcus granulosus neuropeptide FF receptor 2 0.0839 0.6444 0.6715
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0154 0.0218
Schistosoma mansoni hypothetical protein 0.1242 0.9597 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0239 0.0249
Schistosoma mansoni hypothetical protein 0.0164 0.1165 0.1214
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0055 0.0309 0.0322
Echinococcus granulosus neuropeptides capa receptor 0.0611 0.4658 0.4854
Toxoplasma gondii cathepsin CPL 0.0016 0.0007 0.001
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0789 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0352 0.0512
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0611 0.4658 0.4854
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0153 0.0159
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.016 0.0226
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0352 0.0512
Schistosoma mansoni amiloride-sensitive sodium channel-related 0.0178 0.1274 0.1328
Brugia malayi neuropeptide F receptor 0.0611 0.4658 0.4658
Loa Loa (eye worm) TK/CSK protein kinase 0.0036 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0352 0.0512
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0052 0.0286 0.3619
Echinococcus granulosus orexin receptor type 2 0.0611 0.4658 0.4854
Brugia malayi follicle stimulating hormone receptor 0.0611 0.4658 0.4658
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.003
Giardia lamblia hypothetical protein 0.003 0.0115 0.0161
Echinococcus multilocularis adam 0.003 0.0115 0.012
Echinococcus multilocularis tubulin beta 1 chain 0.0894 0.6875 0.7163
Echinococcus granulosus integrin alpha ps 0.0033 0.0135 0.0141
Echinococcus multilocularis protein vprbp 0.0178 0.1274 0.1328
Giardia lamblia High cysteine membrane protein Group 2 0.0056 0.032 0.0459
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0364 0.0529
Loa Loa (eye worm) amiloride-sensitive sodium channel family protein 0.0178 0.1274 0.1274
Leishmania major beta tubulin 0.0894 0.6875 1
Entamoeba histolytica hypothetical protein 0.0035 0.0153 0.0212
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0036 0.016 0.0166
Giardia lamblia Neurogenic locus notch-like protein 0.003 0.0115 0.0161
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0258 0.0258
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0071 0.0104
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0611 0.4658 0.4854
Loa Loa (eye worm) hypothetical protein 0.0085 0.0543 0.0543
Brugia malayi G-protein coupled receptor 0.0611 0.4658 0.4658
Onchocerca volvulus 0.0091 0.0595 0.1263
Giardia lamblia Beta tubulin 0.0894 0.6875 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0154 0.0218
Trypanosoma cruzi beta tubulin, putative 0.0894 0.6875 1
Entamoeba histolytica hypothetical protein 0.0035 0.0153 0.0212
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0153 0.0159
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0006
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0004 0.0006
Brugia malayi Matrixin family protein 0.0043 0.0213 0.0213
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0611 0.4658 0.4854
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.0007
Echinococcus granulosus tyrosine protein kinase Src42A 0.0055 0.0309 0.0322
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0154 0.0218
Onchocerca volvulus 0.004 0.0193 0.0399
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0611 0.4658 0.4854
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0033 0.0141 0.0147
Brugia malayi glutathione reductase 0.0046 0.0239 0.0239
Schistosoma mansoni neuropeptide F-like receptor 0.0611 0.4658 0.4854
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0055 0.0309 0.0322
Leishmania major cathepsin L-like protease 0.0016 0.0007 0.001
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0326 0.034
Leishmania major beta tubulin 0.0894 0.6875 1
Echinococcus multilocularis c src tyrosine kinase 0.0057 0.033 0.0343
Echinococcus multilocularis FMRFamide activated amiloride sensitive sodium 0.0178 0.1274 0.1328
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0611 0.4658 0.4854
Echinococcus granulosus tyrosine protein kinase Fyn 0.0055 0.0309 0.0322
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0154 0.0224
Onchocerca volvulus 0.0611 0.4658 1
Loa Loa (eye worm) hypothetical protein 0.0198 0.1432 0.1432
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0239 0.0249
Echinococcus multilocularis dna polymerase kappa 0.006 0.0352 0.0367
Schistosoma mansoni amine GPCR 0.0611 0.4658 0.4854
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0178 0.1274 0.1274
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0698 0.8844
Onchocerca volvulus 0.0043 0.0213 0.0443
Brugia malayi Serotonin receptor 0.0611 0.4658 0.4658
Echinococcus multilocularis tyrosine protein kinase HCK 0.0033 0.0141 0.0146
Schistosoma mansoni hypothetical protein 0.0035 0.0153 0.0159
Brugia malayi EGF-like domain containing protein 0.003 0.0115 0.0115
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.003 0.0031
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0154 0.0218
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0004 0.0006
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0326 0.034
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0004 0.0005
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0078 0.0107
Mycobacterium ulcerans hydrolase 0.0052 0.0286 0.8082
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Loa Loa (eye worm) SRC-1 0.0055 0.0309 0.0309
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0154 0.0214
Loa Loa (eye worm) doublecortin family protein 0.0019 0.003 0.003
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0341 0.0355
Trichomonas vaginalis tubulin alpha chain, putative 0.0894 0.6875 1
Brugia malayi hypothetical protein 0.0019 0.003 0.003
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0055 0.0309 0.0322
Echinococcus granulosus microtubule associated protein 2 0.0669 0.5111 0.5326
Brugia malayi Matrixin family protein 0.0043 0.0213 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0109 0.0152
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0107 0.0155
Mycobacterium tuberculosis Probable reductase 0.0105 0.0698 0.8844
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0004
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0153 0.016
Echinococcus granulosus fmrfamide receptor 0.0611 0.4658 0.4854
Schistosoma mansoni polycystin 1-related 0.0019 0.003 0.0031
Onchocerca volvulus 0.0611 0.4658 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0154 0.0224
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0004 0.0006
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0341 0.0495
Echinococcus granulosus rhodopsin orphan GPCR 0.0611 0.4658 0.4854
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0109 0.0152
Echinococcus granulosus c src tyrosine kinase 0.0057 0.033 0.0343
Leishmania major beta tubulin 0.0894 0.6875 1
Leishmania major beta tubulin 0.0894 0.6875 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0059 0.0344 0.0344
Echinococcus granulosus neuropeptide receptor 0.0611 0.4658 0.4854
Plasmodium vivax SET domain protein, putative 0.0029 0.0107 0.0155
Schistosoma mansoni adenoreceptor 0.0611 0.4658 0.4854
Echinococcus granulosus serotonin receptor 0.0611 0.4658 0.4854
Loa Loa (eye worm) matrixin family protein 0.0094 0.0618 0.0618
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0004
Loa Loa (eye worm) matrix metalloproteinase 0.0043 0.0213 0.0213
Onchocerca volvulus 0.0611 0.4658 1
Loa Loa (eye worm) tubulin beta-1 chain 0.0894 0.6875 0.6875
Brugia malayi Amiloride-sensitive sodium channel family protein 0.0178 0.1274 0.1274
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0033 0.0141 0.0141
Echinococcus granulosus rhodopsin orphan GPCR 0.0611 0.4658 0.4854
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0611 0.4658 0.4854
Leishmania major beta tubulin 0.0894 0.6875 1
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0113 0.0164
Schistosoma mansoni neuropeptide f receptor 76f 0.0611 0.4658 0.4854
Brugia malayi jmjC domain containing protein 0.0057 0.0326 0.0326
Echinococcus granulosus neuroendocrine convertase 2 0.0095 0.0624 0.065
Brugia malayi M-phase phosphoprotein, mpp8 0.0098 0.0648 0.0648
Schistosoma mansoni tubulin subunit beta 0.0894 0.6875 0.7163
Echinococcus granulosus Tubulin beta 2C chain 0.0894 0.6875 0.7163
Echinococcus multilocularis serotonin receptor 0.0611 0.4658 0.4854
Leishmania major hypothetical protein, conserved 0.0024 0.0071 0.0104
Giardia lamblia Furin precursor putative serine protease 0.0029 0.0109 0.0152
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1115 0.1162
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0071 0.0104
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0154 0.0218
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0364 0.0529
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0109 0.0152
Onchocerca volvulus 0.0611 0.4658 1
Brugia malayi jmjC domain containing protein 0.0057 0.0326 0.0326
Brugia malayi sulfakinin receptor protein 0.0611 0.4658 0.4658
Echinococcus multilocularis g protein coupled receptor 0.0611 0.4658 0.4854
Onchocerca volvulus 0.006 0.0352 0.0742
Loa Loa (eye worm) hypothetical protein 0.0033 0.0139 0.0139
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0258 0.0258
Brugia malayi hypothetical protein 0.0611 0.4658 0.4658
Schistosoma mansoni growth factor receptor-bound protein 0.0022 0.0049 0.0051
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0078 0.0107
Onchocerca volvulus 0.0611 0.4658 1
Giardia lamblia High cysteine protein 0.003 0.0115 0.0161
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0078 0.0113
Echinococcus granulosus single minded 2 0.0038 0.0179 0.0186
Onchocerca volvulus 0.003 0.0115 0.0233
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0004 0.0006
Echinococcus granulosus tyrosine protein kinase Lyn 0.0055 0.0309 0.0322
Brugia malayi putative neuropeptide receptor 0.0611 0.4658 0.4658
Echinococcus granulosus integrin alpha 3 0.0116 0.079 0.0824
Echinococcus granulosus g protein coupled receptor 0.0611 0.4658 0.4854
Loa Loa (eye worm) ctsf protein 0.0016 0.0007 0.0007
Schistosoma mansoni alpha-glucosidase 0.0136 0.0943 0.0983
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0611 0.4658 0.4854
Echinococcus multilocularis beta tubulin 0.0894 0.6875 0.7163
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0055 0.0309 0.0322
Onchocerca volvulus 0.0178 0.1274 0.2724
Brugia malayi Pre-SET motif family protein 0.0029 0.0107 0.0107
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0004 0.0006
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0071 0.0104
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0007 0.0007
Plasmodium falciparum glutathione reductase 0.0016 0.0004 0.0006
Onchocerca volvulus 0.0611 0.4658 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0115 0.0115
Echinococcus multilocularis integrin alpha ps 0.0068 0.0413 0.043
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0078 0.0113
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0352 0.0512
Echinococcus granulosus g-protein coupled receptor 0.0611 0.4658 0.4854
Echinococcus multilocularis Tubulin beta 2C chain 0.0894 0.6875 0.7163
Echinococcus multilocularis g protein coupled receptor 0.0611 0.4658 0.4854
Schistosoma mansoni hypothetical protein 0.0033 0.0135 0.0141
Schistosoma mansoni adapter molecule crk 0.0022 0.0049 0.0051
Brugia malayi Flap endonuclease-1 0.0025 0.0078 0.0078
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.0193 0.0201
Echinococcus multilocularis FMRFamide activated amiloride sensitive sodium 0.0178 0.1274 0.1328
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0155 0.109 0.1136
Brugia malayi Tachykinin-like peptides receptor 99D 0.0839 0.6444 0.6444
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0611 0.4658 0.4854
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0157
Onchocerca volvulus 0.0098 0.0648 0.1378
Brugia malayi protein-tyrosine kinase 0.0044 0.0226 0.0226
Loa Loa (eye worm) hypothetical protein 0.0098 0.0648 0.0648
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0352 0.0512
Leishmania major cathepsin L-like protease 0.0062 0.0364 0.0529
Echinococcus granulosus tachykinin peptides receptor 99D 0.0611 0.4658 0.4854
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0326 0.034
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0364 0.0529
Loa Loa (eye worm) endoprotease bli-4 0.0151 0.1063 0.1063
Echinococcus multilocularis rhodopsin orphan GPCR 0.0611 0.4658 0.4854
Loa Loa (eye worm) hypothetical protein 0.0119 0.0812 0.0812
Echinococcus granulosus somatostatin receptor 0.0611 0.4658 0.4854
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0004
Echinococcus multilocularis FMRFamide activated amiloride sensitive sodium 0.0178 0.1274 0.1328
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0364 0.0529
Schistosoma mansoni tyrosine kinase 0.0025 0.0073 0.0076
Brugia malayi Matrixin family protein 0.0043 0.0213 0.0213
Plasmodium falciparum flap endonuclease 1 0.0025 0.0078 0.0113
Echinococcus multilocularis fmrfamide receptor 0.0611 0.4658 0.4854
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0007 0.001
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0364 0.0529
Brugia malayi hypothetical protein 0.0019 0.003 0.003
Brugia malayi Sex muscle abnormal protein 5 0.0022 0.0049 0.0049
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0006
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0341 0.0355
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0611 0.4658 0.4658
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0055 0.0309 0.0322
Schistosoma mansoni amine GPCR 0.0611 0.4658 0.4854
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0352 0.0512
Echinococcus granulosus beta tubulin 0.0894 0.6875 0.7163
Echinococcus multilocularis integrin alpha ps 0.0033 0.0135 0.0141
Onchocerca volvulus 0.0611 0.4658 1
Onchocerca volvulus 0.0019 0.003 0.0048
Echinococcus multilocularis neuropeptides capa receptor 0.0611 0.4658 0.4854
Trypanosoma brucei DNA polymerase eta, putative 0.0033 0.0141 0.0206
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Echinococcus granulosus fibrillin 2 0.003 0.0115 0.012
Schistosoma mansoni opsin-like receptor 0.0611 0.4658 0.4854
Echinococcus multilocularis G protein coupled receptor 139 0.0611 0.4658 0.4854
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0307 0.2285 0.2285
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.016 0.0167
Leishmania major cathepsin L-like protease 0.0062 0.0364 0.0529
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0098 0.0102
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0326 0.034
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0698 0.8188
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0341 0.9661
Brugia malayi Thioredoxin reductase 0.0046 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Loa Loa (eye worm) hypothetical protein 0.0151 0.1063 0.1063
Loa Loa (eye worm) hypothetical protein 0.0031 0.0123 0.0123
Brugia malayi proprotein convertase 2 0.0095 0.0624 0.0624
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0029 0.0109 0.0152
Trypanosoma brucei beta tubulin 0.0894 0.6875 1
Giardia lamblia High cysteine protein 0.003 0.0115 0.0161
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0071 0.0104
Brugia malayi Variant SH3 domain containing protein 0.0022 0.0049 0.0049
Echinococcus multilocularis tyrosine protein kinase csk 0.0036 0.0161 0.0168
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0341 0.4315
Echinococcus granulosus furin 0.0151 0.1063 0.1108
Loa Loa (eye worm) hypothetical protein 0.0178 0.1274 0.1274
Brugia malayi hypothetical protein 0.0158 0.1117 0.1117
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0789 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0007 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0107 0.0111
Loa Loa (eye worm) BEN-1 protein 0.0894 0.6875 0.6875
Schistosoma mansoni lipoxygenase 0.0114 0.0774 0.0807
Loa Loa (eye worm) beta-tubulin 0.0894 0.6875 0.6875
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0109 0.0152
Schistosoma mansoni loxhd1 0.0019 0.003 0.0031
Brugia malayi Amiloride-sensitive sodium channel family protein 0.0178 0.1274 0.1274
Echinococcus granulosus allatostatin A receptor 0.0611 0.4658 0.4854
Echinococcus granulosus adam 0.003 0.0115 0.012
Trichomonas vaginalis set domain proteins, putative 0.023 0.1676 0.2433
Schistosoma mansoni hypothetical protein 0.0178 0.1274 0.1328
Trypanosoma brucei glucosidase, putative 0.0035 0.0154 0.0224
Loa Loa (eye worm) TYRA-2 protein 0.0611 0.4658 0.4658
Brugia malayi hypothetical protein 0.0098 0.0649 0.0649
Brugia malayi G protein-coupled receptor 0.0611 0.4658 0.4658
Echinococcus granulosus fibrillin 1 0.003 0.0115 0.012
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0078 0.0078
Brugia malayi polk-prov protein 0.0037 0.0172 0.0172
Trypanosoma brucei trypanothione reductase 0.0046 0.0239 0.0347
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0155 0.109 0.1136
Brugia malayi Pre-SET motif family protein 0.0202 0.1458 0.1458
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0364 0.0529
Schistosoma mansoni growth factor receptor-bound protein 0.0022 0.0049 0.0051
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0141 0.0199
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0004
Schistosoma mansoni amiloride-sensitive sodium channel-related 0.0178 0.1274 0.1328
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0341 0.9661
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0044 0.0226 0.0235
Brugia malayi EGF-like domain containing protein 0.003 0.0115 0.0115
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0153 0.0153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0364 0.0529
Schistosoma mansoni tyrosine kinase 0.0055 0.0309 0.0322
Echinococcus multilocularis neuropeptide Y receptor 0.0611 0.4658 0.4854
Leishmania major beta tubulin 0.0894 0.6875 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0194 0.0282
Echinococcus multilocularis geminin 0.0164 0.1165 0.1214
Echinococcus granulosus amiloride sensitive cation channel 4 A 0.0178 0.1274 0.1328
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0153 0.4275
Echinococcus granulosus FMRFamide activated amiloride sensitive sodium 0.0178 0.1274 0.1328
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0154 0.0218
Echinococcus granulosus geminin 0.0164 0.1165 0.1214
Loa Loa (eye worm) glutathione reductase 0.0046 0.0239 0.0239
Echinococcus multilocularis integrin beta 2 0.0955 0.7353 0.7661
Toxoplasma gondii beta-tubulin, putative 0.0894 0.6875 1
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0352 0.0512
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0004 0.0006
Brugia malayi Dopamine receptor protein 1 0.0611 0.4658 0.4658
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0611 0.4658 0.4854
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0055 0.0309 0.0322
Echinococcus multilocularis RUN 0.0019 0.003 0.0031
Echinococcus granulosus amiloride sensitive cation channel 0.0178 0.1274 0.1328
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0611 0.4658 0.4854
Schistosoma mansoni neuropeptide receptor 0.0611 0.4658 0.4854
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0004
Brugia malayi G-protein coupled receptor 0.0611 0.4658 0.4658
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0364 0.0529
Echinococcus granulosus neuropeptides capa receptor 0.0611 0.4658 0.4854
Echinococcus multilocularis somatostatin receptor 0.0611 0.4658 0.4854
Echinococcus granulosus tubulin beta 1 chain 0.0894 0.6875 0.7163
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0611 0.4658 0.4854
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0352 0.0512
Schistosoma mansoni neuropeptide receptor 0.0611 0.4658 0.4854
Schistosoma mansoni myosin xvIII 0.0611 0.4658 0.4854
Echinococcus multilocularis FMRFamide activated amiloride sensitive sodium 0.0178 0.1274 0.1328
Echinococcus multilocularis sodium channel nonvoltage gated 1 alpha 0.0178 0.1274 0.1328
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0022 0.0049 0.0051
Schistosoma mansoni hypothetical protein 0.0033 0.0139 0.0144
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0352 0.0512
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0004 0.0056
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.026 0.0379
Echinococcus multilocularis neuropeptide receptor A26 0.1057 0.8146 0.8488
Echinococcus granulosus tyrosine protein kinase csk 0.0036 0.0161 0.0168
Echinococcus multilocularis Tubulin beta 2C chain 0.0894 0.6875 0.7163
Echinococcus granulosus neuropeptide s receptor 0.1057 0.8146 0.8488
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0071 0.0438 0.0457
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0154 0.0218
Plasmodium vivax vivapain-2 0.0016 0.0007 0.001
Schistosoma mansoni hypothetical protein 0.0178 0.1274 0.1328
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0194 0.2455
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0611 0.4658 0.4854
Schistosoma mansoni neuropeptide receptor 0.0611 0.4658 0.4854
Echinococcus multilocularis Tubulin beta 2C chain 0.0894 0.6875 0.7163
Giardia lamblia Neurogenic locus Notch protein precursor 0.003 0.0115 0.0161
Echinococcus multilocularis 0.0122 0.0834 0.0869
Echinococcus granulosus cathepsin l1 0.0016 0.0007 0.0007
Brugia malayi hypothetical protein 0.0024 0.0071 0.0071
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0029 0.0109 0.0152
Echinococcus multilocularis serotonin receptor 0.0611 0.4658 0.4854
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0228 0.1661 0.1731
Schistosoma mansoni alpha glucosidase 0.0035 0.0154 0.0161
Loa Loa (eye worm) amiloride-sensitive sodium channel family protein 0.0178 0.1274 0.1274
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0004 0.0006
Schistosoma mansoni microtubule-associated protein tau 0.0669 0.5111 0.5326
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0611 0.4658 0.4658
Leishmania major DNA polymerase eta, putative 0.0033 0.0141 0.0206
Loa Loa (eye worm) tubulin beta-2A chain 0.0894 0.6875 0.6875
Giardia lamblia Tenascin-X 0.003 0.0115 0.0161
Loa Loa (eye worm) integrin beta-2 0.1294 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0611 0.4658 0.4854
Brugia malayi hypoxia-induced factor 1 0.0146 0.1022 0.1022
Echinococcus multilocularis neuropeptide s receptor 0.1057 0.8146 0.8488
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0107 0.0111
Echinococcus multilocularis rhodopsin orphan GPCR 0.0611 0.4658 0.4854
Loa Loa (eye worm) hypothetical protein 0.0158 0.1117 0.1117
Echinococcus granulosus alpha 1A adrenergic receptor 0.0611 0.4658 0.4854
Loa Loa (eye worm) hypothetical protein 0.0084 0.0535 0.0535
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0107 0.0111
Brugia malayi hypothetical protein 0.0611 0.4658 0.4658
Schistosoma mansoni hypothetical protein 0.0164 0.1165 0.1214
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0004 0.5
Onchocerca volvulus 0.0611 0.4658 1
Echinococcus granulosus Tubulin beta 2C chain 0.0894 0.6875 0.7163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0004
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.016 0.0167
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0154 0.0214
Schistosoma mansoni rab6-interacting 0.0019 0.003 0.0031
Brugia malayi GnHR receptor homolog 0.0611 0.4658 0.4658
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0611 0.4658 0.4854
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.003 0.0043
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0611 0.4658 0.4854
Echinococcus granulosus rhodopsin orphan GPCR 0.0611 0.4658 0.4854
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0172 0.0251
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0052 0.0286 0.0286
Echinococcus granulosus tyrosine protein kinase HCK 0.0033 0.0141 0.0146
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0139 0.0139
Schistosoma mansoni neuropeptide F-like receptor 0.0611 0.4658 0.4854
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0239 0.0239
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0004
Brugia malayi Tubulin beta-1 chain 0.0894 0.6875 0.6875
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0022 0.0049 0.0049
Schistosoma mansoni furin-1 (S08 family) 0.0066 0.0395 0.0411
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0107 0.0111
Loa Loa (eye worm) proprotein convertase 2 0.0036 0.016 0.016
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0344 0.0359
Echinococcus granulosus tm gpcr rhodopsin 0.0611 0.4658 0.4854
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0004
Echinococcus granulosus g protein coupled receptor 0.0611 0.4658 0.4854
Entamoeba histolytica deoxycytidyl transferase, putative 0.0033 0.0141 0.0195
Schistosoma mansoni tubulin subunit beta 0.0894 0.6875 0.7163
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0033 0.0141 0.0147
Onchocerca volvulus 0.0611 0.4658 1
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0078 0.0081
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Entamoeba histolytica hypothetical protein 0.0035 0.0153 0.0212
Brugia malayi Hemopexin family protein 0.006 0.0352 0.0352
Echinococcus granulosus tubulin subunit beta 0.0894 0.6875 0.7163
Echinococcus granulosus 7TM GPCR rhodopsin 0.0611 0.4658 0.4854
Echinococcus granulosus hypothetical protein 0.0611 0.4658 0.4854
Plasmodium falciparum thioredoxin reductase 0.0046 0.0239 0.0347
Echinococcus granulosus flap endonuclease 1 0.0025 0.0078 0.0081
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0114 0.0774 0.0807
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0115 0.0778 0.0778
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.1115 0.1115
Echinococcus multilocularis dnaJ subfamily B 0.1242 0.9597 1
Brugia malayi putative neuropeptide receptor NPR1 0.0611 0.4658 0.4658
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0154 0.0161
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1115 0.1162
Echinococcus granulosus tyrosine protein kinase Blk 0.0044 0.0226 0.0235
Brugia malayi Dopamine receptor protein 2 0.0611 0.4658 0.4658
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0109 0.0152
Echinococcus multilocularis NCK adaptor protein 0.0022 0.0049 0.0051
Echinococcus multilocularis rhodopsin orphan GPCR 0.0611 0.4658 0.4854
Echinococcus multilocularis tyrosine protein kinase csk 0.0036 0.0161 0.0168
Brugia malayi SRC-1 0.0055 0.0309 0.0309
Trypanosoma brucei beta tubulin 0.0894 0.6875 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0611 0.4658 0.4854
Echinococcus granulosus integrin beta 2 0.0955 0.7353 0.7661
Loa Loa (eye worm) SH2 domain-containing protein 0.0044 0.0222 0.0222
Echinococcus granulosus amiloride sensitive sodium channel 0.0178 0.1274 0.1328
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0007 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0611 0.4658 0.4854
Echinococcus granulosus tyrosine protein kinase Src42A 0.0041 0.0202 0.021
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0006
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0141 0.0199
Schistosoma mansoni FMRFamide-gated Na+ channel 0.0178 0.1274 0.1328
Plasmodium vivax vivapain-2 0.0016 0.0007 0.001
Leishmania major beta tubulin 0.0894 0.6875 1
Echinococcus multilocularis microtubule associated protein 2 0.0669 0.5111 0.5326
Schistosoma mansoni tyrosine kinase 0.0217 0.1576 0.1642
Leishmania major beta tubulin 0.0894 0.6875 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.016 0.0226
Trichomonas vaginalis tubulin epsilon chain, putative 0.0894 0.6875 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0789 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0004
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0611 0.4658 0.4854
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0092 0.0599 0.0866
Loa Loa (eye worm) G-protein coupled receptor 0.0611 0.4658 0.4658
Trypanosoma brucei unspecified product 0.0023 0.006 0.0088
Echinococcus granulosus Furin 1 0.0036 0.016 0.0166
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.003 0.0031
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.003 0.0031
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0141 0.0206
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.003 0.0115 0.0161
Brugia malayi Degenerin mec-4 0.0178 0.1274 0.1274
Onchocerca volvulus 0.0611 0.4658 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0004 0.5
Echinococcus multilocularis tyrosine protein kinase Srms 0.0044 0.0226 0.0235
Echinococcus granulosus Tubulin beta 2C chain 0.0894 0.6875 0.7163
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.006 0.0352 0.0506
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0004
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0352 0.0512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0004
Loa Loa (eye worm) TK/ABL protein kinase 0.0228 0.1661 0.1661
Schistosoma mansoni integrin alpha 0.0152 0.1068 0.1112
Trypanosoma brucei DNA polymerase IV, putative 0.0054 0.03 0.0436
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0004 0.0006
Echinococcus granulosus biogenic amine 5HT receptor 0.0611 0.4658 0.4854
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0326 0.0326
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0611 0.4658 0.4854
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Plasmodium vivax tubulin beta chain, putative 0.0894 0.6875 1
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0007 0.001
Schistosoma mansoni integrin alpha-ps 0.0035 0.0157 0.0164
Leishmania major cathepsin L-like protease 0.0016 0.0007 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.016 0.0226
Schistosoma mansoni hypothetical protein 0.0019 0.003 0.0031
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0341 0.0355
Echinococcus granulosus tm gpcr rhodopsin 0.0611 0.4658 0.4854
Schistosoma mansoni tyrosine kinase 0.0055 0.0309 0.0322
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0109 0.0152
Loa Loa (eye worm) hypothetical protein 0.0178 0.1274 0.1274
Echinococcus multilocularis neuroendocrine convertase 2 0.0095 0.0624 0.065
Schistosoma mansoni DNA polymerase eta 0.0033 0.0141 0.0147
Onchocerca volvulus Matrix metalloproteinase homolog 0.0094 0.0618 0.1314
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0078 0.0103
Brugia malayi Melatonin receptor type 1A 0.0611 0.4658 0.4658
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0055 0.0309 0.0322
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0055 0.0309 0.0322
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.003 0.0031
Leishmania major cathepsin L-like protease 0.0016 0.0007 0.001
Brugia malayi hypothetical protein 0.0611 0.4658 0.4658
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Loa Loa (eye worm) hypothetical protein 0.003 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0178 0.1274 0.1328
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0611 0.4658 0.4854
Echinococcus multilocularis FMRFamide activated amiloride sensitive sodium 0.0178 0.1274 0.1328
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0611 0.4658 0.4854
Schistosoma mansoni flap endonuclease-1 0.0023 0.0059 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0109 0.0152
Leishmania major cathepsin L-like protease 0.0062 0.0364 0.0529
Echinococcus granulosus tubulin beta 4A class IVa 0.0894 0.6875 0.7163
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.0007
Schistosoma mansoni single-minded 0.0047 0.0249 0.0259
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0109 0.0152
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0007 0.0007
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0611 0.4658 0.4854
Entamoeba histolytica tubulin family protein 0.0894 0.6875 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0611 0.4658 0.4658
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0611 0.4658 0.4658
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0044 0.0226 0.0235
Loa Loa (eye worm) hypothetical protein 0.0115 0.0778 0.0778
Loa Loa (eye worm) neuropeptide F receptor 0.0611 0.4658 0.4658
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0022 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0178 0.1274 0.1274
Echinococcus multilocularis tyrosine protein kinase Abl 0.0106 0.0712 0.0742
Leishmania major beta tubulin 0.0894 0.6875 1
Brugia malayi hypothetical protein 0.0035 0.0153 0.0153
Schistosoma mansoni hypothetical protein 0.0611 0.4658 0.4854
Brugia malayi hypothetical protein 0.0016 0.0004 0.0004
Giardia lamblia Beta tubulin 0.0894 0.6875 1
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Leishmania major protein kinase, putative 0.0017 0.0013 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0364 0.0529
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0154 0.0224
Brugia malayi EGF-like domain containing protein 0.003 0.0115 0.0115
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0078 0.0113
Echinococcus granulosus dna polymerase eta 0.0033 0.0141 0.0147
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0352 1
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0141 0.0141
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0007 0.001
Onchocerca volvulus 0.0611 0.4658 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0611 0.4658 0.4854
Brugia malayi endoprotease bli-4 precursor 0.0151 0.1063 0.1063
Trichomonas vaginalis tubulin, putative 0.0894 0.6875 1
Echinococcus granulosus NCK adaptor protein 0.0022 0.0049 0.0051
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.016 0.0226
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Schistosoma mansoni biogenic amine receptor 0.0611 0.4658 0.4854
Echinococcus multilocularis Furin 1 0.0036 0.016 0.0166
Loa Loa (eye worm) hypothetical protein 0.0029 0.0107 0.0107
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0341 0.0495
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0022 0.0049 0.0049
Brugia malayi neuropeptide F receptor 0.0611 0.4658 0.4658
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0326 0.034
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0611 0.4658 0.4854
Brugia malayi hypothetical protein 0.0611 0.4658 0.4658
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.003 0.0031
Leishmania major beta tubulin 0.0894 0.6875 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0107 0.0111
Schistosoma mansoni acid sensing ion channel 4 pituitary 0.0178 0.1274 0.1328
Loa Loa (eye worm) cysteine protease 0.0016 0.0007 0.0007
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.003 0.0043
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Echinococcus granulosus 7tm_1 domain containing protein 0.0611 0.4658 0.4854
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Echinococcus granulosus nuclear factor of activated T cells 5 0.0071 0.0438 0.0457
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0007 0.0007
Onchocerca volvulus 0.0611 0.4658 1
Brugia malayi neuroendocrine convertase 1 precursor 0.0095 0.0624 0.0624
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0344 0.0359
Echinococcus multilocularis fmrfamide receptor 0.0611 0.4658 0.4854
Trichomonas vaginalis tubulin gamma chain, putative 0.0894 0.6875 1
Loa Loa (eye worm) hypothetical protein 0.0178 0.1274 0.1274
Schistosoma mansoni tubulin subunit beta 0.0894 0.6875 0.7163
Giardia lamblia Tenascin precursor 0.003 0.0115 0.0161
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0007 0.0007
Loa Loa (eye worm) melatonin receptor type 1A 0.0611 0.4658 0.4658
Echinococcus granulosus peptide allatostatin:somatostatin 0.0611 0.4658 0.4854
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0326 0.034
Echinococcus multilocularis FMRFamide activated amiloride sensitive sodium 0.0178 0.1274 0.1328
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0789 1
Echinococcus granulosus tyrosine protein kinase csk 0.0036 0.0161 0.0168
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0341 0.9661
Loa Loa (eye worm) hypothetical protein 0.0048 0.0258 0.0258
Echinococcus multilocularis amiloride sensitive cation channel 4 A 0.0178 0.1274 0.1328
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0113 0.0164
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0364 0.0529
Trypanosoma brucei unspecified product 0.0054 0.03 0.0436
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.016 0.0226
Loa Loa (eye worm) hypothetical protein 0.0611 0.4658 0.4658
Brugia malayi Degenerin unc-8 0.0178 0.1274 0.1274
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0352 0.0512
Echinococcus multilocularis dro:myosuppressin receptor 0.0611 0.4658 0.4854
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0352 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0004 0.0005
Echinococcus granulosus Na channel amiloride sensitive 0.0178 0.1274 0.1328
Schistosoma mansoni integrin alpha-ps 0.0068 0.0413 0.043
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0611 0.4658 0.4854
Schistosoma mansoni biogenic amine (5HT) receptor 0.0611 0.4658 0.4854
Echinococcus multilocularis neuropeptides capa receptor 0.0611 0.4658 0.4854
Loa Loa (eye worm) hypothetical protein 0.0098 0.0649 0.0649
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0611 0.4658 0.4854
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0055 0.0309 0.0322
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0178 0.1274 0.1274
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.016 0.016
Leishmania major DNA polymerase kappa, putative 0.004 0.0194 0.0282
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0055 0.0309 0.0322
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0004 0.0006
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.0344 0.4364
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0352 0.0512
Brugia malayi hypothetical protein 0.0611 0.4658 0.4658
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0611 0.4658 0.4854
Trypanosoma brucei beta tubulin 0.0894 0.6875 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.1115 0.1115
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0611 0.4658 0.4854
Echinococcus granulosus tyrosine protein kinase Src64B 0.0055 0.0309 0.0322
Brugia malayi hypothetical protein 0.0198 0.1432 0.1432
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0698 0.8844
Brugia malayi hypothetical protein 0.0611 0.4658 0.4658
Trichomonas vaginalis tubulin epsilon chain, putative 0.0894 0.6875 1
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0352 0.0512
Loa Loa (eye worm) TK protein kinase 0.0033 0.0141 0.0141
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.1115 0.1162
Onchocerca volvulus 0.0611 0.4658 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0004 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0352 0.0512
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0153 0.0159
Plasmodium falciparum tubulin beta chain 0.0894 0.6875 1
Trypanosoma brucei unspecified product 0.0023 0.006 0.0088
Echinococcus multilocularis neuropeptide FF receptor 2 0.0839 0.6444 0.6715
Schistosoma mansoni neuropeptide receptor 0.0611 0.4658 0.4854
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0611 0.4658 0.4854
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0033 0.0141 0.0147
Schistosoma mansoni hypothetical protein 0.0611 0.4658 0.4854
Onchocerca volvulus 0.0178 0.1274 0.2724
Echinococcus multilocularis neuropeptide receptor 0.0611 0.4658 0.4854
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0198 0.1432 0.1432
Echinococcus granulosus biogenic amine 5HT receptor 0.0611 0.4658 0.4854
Schistosoma mansoni integrin beta subunit 0.0757 0.5801 0.6044
Schistosoma mansoni tubulin subunit beta 0.0894 0.6875 0.7163
Schistosoma mansoni biogenic amine receptor 0.0611 0.4658 0.4854
Leishmania major cathepsin L-like protease 0.0016 0.0007 0.001
Echinococcus multilocularis tyrosine protein kinase Blk 0.0044 0.0226 0.0235
Echinococcus multilocularis Na+ channel, amiloride sensitive 0.0178 0.1274 0.1328
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0611 0.4658 0.4854
Echinococcus multilocularis amiloride sensitive cation channel 4 A 0.0178 0.1274 0.1328
Schistosoma mansoni hypothetical protein 0.0178 0.1274 0.1328
Schistosoma mansoni hypothetical protein 0.0178 0.1274 0.1328

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 125 uM Antibacterial activity against Escherichia coli ATCC 25922 incubated in dark for 30 mins followed by exposure to light fluences at 650 nm and 6 J/cm2 and then incubated overnight measured after 24 hrs ChEMBL. 25544685

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.