Detailed information for compound 2076172

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 456.416 | Formula: C20H23F3N4O5
  • H donors: 1 H acceptors: 5 LogP: 2.36 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(F)(F)F.Cc1ccoc1C(=O)N1CCOCC2(C1)CCN(C2)c1ncccn1
  • InChi: 1S/C18H22N4O3.C2HF3O2/c1-14-3-9-25-15(14)16(23)21-8-10-24-13-18(11-21)4-7-22(12-18)17-19-5-2-6-20-17;3-2(4,5)1(6)7/h2-3,5-6,9H,4,7-8,10-13H2,1H3;(H,6,7)
  • InChiKey: DKALWSIBMTUTBV-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) animal heme peroxidase 0.009 0.1011 0.1011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0019 0.0019
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0074 0.0804 0.0804
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0019 0.0019
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0204 0.2451 0.2451
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0019 0.0019
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0392 0.0356
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0074 0.0804 0.1378
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0074 0.0804 0.1378
Loa Loa (eye worm) hypothetical protein 0.0041 0.0392 0.0392
Mycobacterium tuberculosis Probable dehydrogenase 0.0074 0.0804 0.0429
Onchocerca volvulus 0.0041 0.0392 0.0896
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0074 0.0804 0.0804
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0074 0.0804 0.0429
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0019 0.0019
Schistosoma mansoni coup transcription factor 0.0012 0.0019 0.0019
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0019 0.0019
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0144 0.1689 0.1689
Brugia malayi hypothetical protein 0.009 0.1011 0.1011
Trypanosoma brucei trypanothione reductase 0.0802 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0019 0.0019
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0074 0.0804 0.0429
Leishmania major hypothetical protein, conserved 0.0074 0.0804 0.077
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0804 0.077
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.0804 0.2293
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0074 0.0804 0.077
Schistosoma mansoni thyroid hormone receptor 0.0155 0.1835 0.1835
Loa Loa (eye worm) hypothetical protein 0.009 0.1011 0.1011
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0019 0.0019
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0392 0.0392
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0075 0.0825 0.0825
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0074 0.0804 0.0804
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0204 0.2451 0.2451
Echinococcus multilocularis peroxidasin 0.009 0.1011 0.1011
Loa Loa (eye worm) blistered cuticle protein 3 0.009 0.1011 0.1011
Plasmodium vivax ferrodoxin reductase, putative 0.0074 0.0804 0.0729
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0074 0.0804 0.077
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.0804 0.2293
Schistosoma mansoni disulfide oxidoreductase 0.0074 0.0804 0.0804
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0278 0.3382 0.3328
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0019 0.0019
Onchocerca volvulus 0.009 0.1011 0.238
Schistosoma mansoni hypothetical protein 0.0387 0.4761 0.4761
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0074 0.0804 0.077
Loa Loa (eye worm) hypothetical protein 0.0019 0.0118 0.0118
Loa Loa (eye worm) beta-lactamase 0.0041 0.0392 0.0392
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0074 0.0804 0.077
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0074 0.0804 0.2293
Toxoplasma gondii NADPH-glutathione reductase 0.0278 0.3382 0.3382
Plasmodium falciparum ferrodoxin reductase-like protein 0.0074 0.0804 0.0804
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.3382 0.3357
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0074 0.0804 0.077
Mycobacterium ulcerans dehydrogenase 0.0074 0.0804 0.1378
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0074 0.0804 0.077
Brugia malayi hypothetical protein 0.0342 0.4186 0.4186
Toxoplasma gondii ABC1 family protein 0.0041 0.0392 0.0392
Trichomonas vaginalis apoptosis inducing factor, putative 0.0074 0.0804 0.2293
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0019 0.0019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.3382 0.3357
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0074 0.0804 0.1378
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0278 0.3382 0.3112
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0074 0.0804 0.2293
Plasmodium falciparum glutathione reductase 0.0802 1 1
Trypanosoma cruzi trypanothione reductase, putative 0.0278 0.3382 0.3357
Brugia malayi ecdysteroid receptor 0.0012 0.0019 0.0019
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0392 0.1061
Loa Loa (eye worm) animal heme peroxidase 0.009 0.1011 0.1011
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0074 0.0804 0.0729
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0074 0.0804 0.0804
Plasmodium falciparum thioredoxin reductase 0.0278 0.3382 0.3382
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0074 0.0804 0.077
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0392 0.0392
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0181 0.0181
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0074 0.0804 0.0804
Brugia malayi Animal haem peroxidase family protein 0.009 0.1011 0.1011
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0392 0.0356
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0278 0.3382 0.3357
Schistosoma mansoni sulfide quinone reductase 0.0074 0.0804 0.0804
Schistosoma mansoni hypothetical protein 0.0144 0.1689 0.1689
Mycobacterium tuberculosis Probable reductase 0.0074 0.0804 0.0429
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0392 0.1061
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.0804 0.2293
Trichomonas vaginalis glutathione reductase, putative 0.0278 0.3382 1
Echinococcus multilocularis geminin 0.0387 0.4761 0.4761
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0278 0.3382 0.3112
Brugia malayi Animal haem peroxidase family protein 0.009 0.1011 0.1011
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0074 0.0804 0.077
Entamoeba histolytica hypothetical protein, conserved 0.0342 0.4186 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.0804 0.2293
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.3382 0.3357
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0074 0.0804 0.0429
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0074 0.0804 0.0804
Echinococcus granulosus peroxidasin 0.009 0.1011 0.1011
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0074 0.0804 0.1849
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0074 0.0804 0.0804
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0019 0.0019
Trichomonas vaginalis esterase, putative 0.0041 0.0392 0.1061
Loa Loa (eye worm) hypothetical protein 0.0362 0.4449 0.4449
Schistosoma mansoni glutamate synthase 0.0074 0.0804 0.0804
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0278 0.3382 0.3382
Schistosoma mansoni hypothetical protein 0.0074 0.0804 0.0804
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.3382 0.3357
Echinococcus multilocularis thioredoxin glutathione reductase 0.0802 1 1
Onchocerca volvulus Peroxidase homolog 0.009 0.1011 0.238
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.0804 0.2293
Loa Loa (eye worm) RecQ helicase 0.0024 0.0181 0.0181
Echinococcus granulosus bloom syndrome protein 0.0024 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0074 0.0804 0.1378
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0074 0.0804 0.0429
Echinococcus multilocularis glutamate synthase 0.0074 0.0804 0.0804
Echinococcus multilocularis protein cereblon 0.0342 0.4186 0.4186
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0074 0.0804 0.1378
Trypanosoma brucei NADH dehydrogenase 0.0074 0.0804 0.077
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0019 0.0019
Giardia lamblia NADH oxidase lateral transfer candidate 0.0278 0.3382 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0074 0.0804 0.2293
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0074 0.0804 0.0729
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0278 0.3382 1
Brugia malayi beta-lactamase family protein 0.0041 0.0392 0.0392
Onchocerca volvulus 0.009 0.1011 0.238
Loa Loa (eye worm) hypothetical protein 0.009 0.1011 0.1011
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0392 0.1061
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.009 0.1011 0.1011
Brugia malayi nuclear hormone receptor 0.0012 0.0019 0.0019
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0075 0.0825 0.0825
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0074 0.0804 0.0804
Echinococcus granulosus geminin 0.0387 0.4761 0.4761
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.009 0.1011 0.1011
Brugia malayi Thioredoxin reductase 0.0802 1 1
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0074 0.0804 0.1378
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0074 0.0804 0.0804
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0265 0.3214 0.3214
Trichomonas vaginalis glutamate synthase, putative 0.0074 0.0804 0.2293
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0019 0.0019
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0019 0.0019
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0074 0.0804 0.2378
Mycobacterium ulcerans glutamate synthase subunit beta 0.0074 0.0804 0.1378
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0019 0.0019
Plasmodium falciparum thioredoxin reductase 0.0802 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0804 0.077
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0019 0.0019
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0802 1 1
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0074 0.0804 0.077
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0019 0.0019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.3382 0.3357
Brugia malayi nuclear receptor NHR-88 0.0012 0.0019 0.0019
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0278 0.3382 0.3382
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0074 0.0804 0.0804
Brugia malayi steroid hormone receptor 0.0012 0.0019 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0019 0.0019
Plasmodium vivax glutathione reductase, putative 0.0802 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0019 0.0019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0019 0.0019
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0019 0.0019
Trichomonas vaginalis mercuric reductase, putative 0.0278 0.3382 1
Leishmania major trypanothione reductase 0.0802 1 1
Mycobacterium ulcerans NADH dehydrogenase 0.0074 0.0804 0.1378
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0804 0.077
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0392 0.0392
Onchocerca volvulus Peroxidasin homolog 0.009 0.1011 0.238
Brugia malayi follicle stimulating hormone receptor 0.0265 0.3214 0.3214
Trypanosoma cruzi NADH dehydrogenase, putative 0.0074 0.0804 0.077
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0392 0.1061
Onchocerca volvulus Protein cereblon homolog 0.0342 0.4186 1
Onchocerca volvulus 0.009 0.1011 0.238
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0019 0.0019
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0278 0.3382 0.3382
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0019 0.0019
Giardia lamblia Glutamate synthase 0.0074 0.0804 0.2378
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0074 0.0804 0.0804
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0074 0.0804 0.0804
Loa Loa (eye worm) hypothetical protein 0.009 0.1011 0.1011
Brugia malayi hypothetical protein 0.0139 0.1629 0.1629
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0074 0.0804 0.1378
Loa Loa (eye worm) hypothetical protein 0.009 0.1011 0.1011
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0278 0.3382 0.3382
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0278 0.3382 1
Echinococcus granulosus protein cereblon 0.0342 0.4186 0.4186
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0143 0.0143
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0019 0.0019
Leishmania major hypothetical protein, conserved 0.0041 0.0392 0.0356
Schistosoma mansoni hypothetical protein 0.0387 0.4761 0.4761
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0278 0.3382 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0019 0.0019
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0074 0.0804 0.1849
Loa Loa (eye worm) thioredoxin reductase 0.0802 1 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0074 0.0804 0.0804
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0019 0.0019
Onchocerca volvulus Peroxidasin homolog 0.009 0.1011 0.238
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Entamoeba histolytica disulphide oxidoreductase, putative 0.0074 0.0804 0.1849
Brugia malayi Blistered cuticle protein 3 0.009 0.1011 0.1011
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0392 0.0392
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0075 0.0825 0.0791
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0278 0.3382 0.3357
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0074 0.0804 0.0429
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0019 0.0019
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.000000000057866 0.000000000057866
Brugia malayi beta-lactamase 0.0041 0.0392 0.0392
Brugia malayi Animal haem peroxidase family protein 0.009 0.1011 0.1011
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0181 0.0429
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0019 0.0019
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0074 0.0804 0.0804
Echinococcus granulosus transcription factor Dp 1 0.0044 0.0424 0.0424
Plasmodium falciparum glutathione reductase 0.0278 0.3382 0.3382
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0825 0.0791
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0019 0.0019
Onchocerca volvulus Chorion peroxidase homolog 0.009 0.1011 0.238
Schistosoma mansoni thyroid hormone receptor 0.0155 0.1835 0.1835
Mycobacterium ulcerans ferredoxin reductase 0.0074 0.0804 0.1378
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0074 0.0804 0.0804
Entamoeba histolytica thioredoxin reductase, putative 0.0074 0.0804 0.1849
Echinococcus granulosus glutamate synthase 0.0074 0.0804 0.0804
Treponema pallidum NADH oxidase 0.0278 0.3382 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0278 0.3382 0.3357
Onchocerca volvulus 0.0074 0.0804 0.1885
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0074 0.0804 0.1378
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0278 0.3382 0.3357
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0278 0.3382 0.3357
Trypanosoma cruzi NADH dehydrogenase, putative 0.0074 0.0804 0.077
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.3382 0.3357
Mycobacterium ulcerans hypothetical protein 0.0074 0.0804 0.1378
Loa Loa (eye worm) hypothetical protein 0.0041 0.0392 0.0392
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0075 0.0825 0.1899
Brugia malayi Animal haem peroxidase family protein 0.009 0.1011 0.1011
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0278 0.3382 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0144 0.1689 0.1689
Schistosoma mansoni hypothetical protein 0.0342 0.4186 0.4186
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0074 0.0804 0.0804
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0019 0.0019
Schistosoma mansoni sulfide quinone reductase 0.0074 0.0804 0.0804
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0074 0.0804 0.1378
Trypanosoma cruzi trypanothione reductase, putative 0.0802 1 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0074 0.0804 0.0429
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0019 0.0019
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0278 0.3382 0.3357
Schistosoma mansoni peroxidasin 0.009 0.1011 0.1011
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0019 0.0019
Leishmania major NADH dehydrogenase, putative 0.0074 0.0804 0.077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0019 0.0019
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0278 0.3382 0.3357
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0278 0.3382 0.3382
Loa Loa (eye worm) hypothetical protein 0.009 0.1011 0.1011
Trichomonas vaginalis glutamate synthase, putative 0.0074 0.0804 0.2293
Brugia malayi Peroxidasin 0.009 0.1011 0.1011
Loa Loa (eye worm) glutathione reductase 0.0802 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0019 0.0019
Loa Loa (eye worm) animal heme peroxidase 0.009 0.1011 0.1011
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0019 0.0019
Brugia malayi beta-lactamase family protein 0.0041 0.0392 0.0392
Schistosoma mansoni glutamate synthase 0.0074 0.0804 0.0804
Brugia malayi glutamate synthase 0.0074 0.0804 0.0804
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0825 0.0791
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0019 0.0019
Leishmania major hypothetical protein, conserved 0.0074 0.0804 0.077
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0074 0.0804 0.0804
Loa Loa (eye worm) hypothetical protein 0.009 0.1011 0.1011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0019 0.0019
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0074 0.0804 0.1378
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0074 0.0804 0.0429
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0074 0.0804 0.1378
Loa Loa (eye worm) hypothetical protein 0.0342 0.4186 0.4186
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0019 0.0019
Loa Loa (eye worm) programmed cell death 8 0.0074 0.0804 0.0804
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0278 0.3382 0.3382
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0074 0.0804 0.0804
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0074 0.0804 0.0804
Plasmodium vivax thioredoxin reductase, putative 0.0802 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0392 0.0392
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.009 0.1011 0.1011
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.0804 0.2293
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.0424 0.0424
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0278 0.3382 0.3357
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0278 0.3382 1
Onchocerca volvulus Dual oxidase homolog 0.009 0.1011 0.238
Loa Loa (eye worm) hypothetical protein 0.0041 0.0392 0.0392
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0074 0.0804 0.2293
Giardia lamblia Thioredoxin reductase 0.0074 0.0804 0.2378
Schistosoma mansoni peroxidasin 0.009 0.1011 0.1011
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0278 0.3382 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0075 0.0825 0.0825
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0074 0.0804 0.0804
Loa Loa (eye worm) hypothetical protein 0.009 0.1011 0.1011
Loa Loa (eye worm) hypothetical protein 0.0041 0.0392 0.0392
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0116 0.0116
Mycobacterium tuberculosis Probable oxidoreductase 0.0278 0.3382 0.3112
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0074 0.0804 0.077
Loa Loa (eye worm) hypothetical protein 0.009 0.1011 0.1011
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0019 0.0019
Onchocerca volvulus 0.0041 0.0392 0.0896
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0074 0.0804 0.0804
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0074 0.0804 0.0429
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0278 0.3382 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0263 0.3191 0.2913
Loa Loa (eye worm) hypothetical protein 0.0041 0.0392 0.0392
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0074 0.0804 0.0429
Toxoplasma gondii thioredoxin reductase 0.0802 1 1
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0074 0.0804 0.0429
Toxoplasma gondii selenide, water dikinase 0.0074 0.0804 0.0804
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0075 0.0825 0.0825
Onchocerca volvulus 0.0041 0.0392 0.0896
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0075 0.0825 0.0825
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.009 0.1011 0.1011
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0074 0.0804 0.077
Loa Loa (eye worm) hypothetical protein 0.009 0.1011 0.1011
Schistosoma mansoni glutamate synthase 0.0074 0.0804 0.0804
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0074 0.0804 0.0804
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0019 0.0019
Echinococcus multilocularis thyroid hormone receptor alpha 0.0155 0.1835 0.1835
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0019 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0019 0.0019
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0074 0.0804 0.1849
Onchocerca volvulus Peroxidase homolog 0.009 0.1011 0.238
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0825 0.0791
Loa Loa (eye worm) hypothetical protein 0.0074 0.0804 0.0804
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0278 0.3382 0.3357
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0074 0.0804 0.1849
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0181 0.0181
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0074 0.0804 0.0804
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0392 0.0314
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0074 0.0804 0.1849
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0278 0.3382 0.3328
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0019 0.0019
Mycobacterium ulcerans monoxygenase 0.0074 0.0804 0.1378
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0278 0.3382 0.3382
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0392 0.0356
Loa Loa (eye worm) animal heme peroxidase 0.009 0.1011 0.1011
Echinococcus granulosus thioredoxin glutathione reductase 0.0802 1 1
Loa Loa (eye worm) hypothetical protein 0.009 0.1011 0.1011
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0392 0.1061
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0181 0.0429
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0278 0.3382 0.3357
Leishmania major hypothetical protein, conserved 0.0074 0.0804 0.077
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0074 0.0804 0.1378
Brugia malayi Animal haem peroxidase family protein 0.009 0.1011 0.1011
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0278 0.3382 0.3112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0019 0.0019
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0392 0.0392
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0019 0.0019

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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