TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 456.416 | Formula: C20H23F3N4O5
H donors: 1 H acceptors: 5 LogP: 2.36 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C(F)(F)F.Cc1ccoc1C(=O)N1CCOCC2(C1)CCN(C2)c1ncccn1
InChi: 1S/C18H22N4O3.C2HF3O2/c1-14-3-9-25-15(14)16(23)21-8-10-24-13-18(11-21)4-7-22(12-18)17-19-5-2-6-20-17;3-2(4,5)1(6)7/h2-3,5-6,9H,4,7-8,10-13H2,1H3;(H,6,7)
InChiKey: DKALWSIBMTUTBV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	animal heme peroxidase	0.009	0.1011	0.1011
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0019	0.0019
Echinococcus multilocularis	apoptosis inducing factor 1 mitochondrial	0.0074	0.0804	0.0804
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0019	0.0019
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0019	0.0019
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0204	0.2451	0.2451
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0019	0.0019
Trypanosoma brucei	hypothetical protein, conserved	0.0041	0.0392	0.0356
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprA	0.0074	0.0804	0.1378
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprB	0.0074	0.0804	0.1378
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0392	0.0392
Mycobacterium tuberculosis	Probable dehydrogenase	0.0074	0.0804	0.0429
Onchocerca volvulus		0.0041	0.0392	0.0896
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0074	0.0804	0.0804
Mycobacterium tuberculosis	Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate	0.0074	0.0804	0.0429
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0019	0.0019
Schistosoma mansoni	coup transcription factor	0.0012	0.0019	0.0019
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0019	0.0019
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0144	0.1689	0.1689
Brugia malayi	hypothetical protein	0.009	0.1011	0.1011
Trypanosoma brucei	trypanothione reductase	0.0802	1	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0019	0.0019
Mycobacterium tuberculosis	Possible dehydrogenase/reductase	0.0074	0.0804	0.0429
Leishmania major	hypothetical protein, conserved	0.0074	0.0804	0.077
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.0804	0.077
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0074	0.0804	0.2293
Trypanosoma cruzi	pyridine nucleotide-disulphide oxidoreductase, putative	0.0074	0.0804	0.077
Schistosoma mansoni	thyroid hormone receptor	0.0155	0.1835	0.1835
Loa Loa (eye worm)	hypothetical protein	0.009	0.1011	0.1011
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0019	0.0019
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.0392	0.0392
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0075	0.0825	0.0825
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0074	0.0804	0.0804
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0204	0.2451	0.2451
Echinococcus multilocularis	peroxidasin	0.009	0.1011	0.1011
Loa Loa (eye worm)	blistered cuticle protein 3	0.009	0.1011	0.1011
Plasmodium vivax	ferrodoxin reductase, putative	0.0074	0.0804	0.0729
Leishmania major	2,4-dienoyl-coa reductase-like protein	0.0074	0.0804	0.077
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0074	0.0804	0.2293
Schistosoma mansoni	disulfide oxidoreductase	0.0074	0.0804	0.0804
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0278	0.3382	0.3328
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0019	0.0019
Onchocerca volvulus		0.009	0.1011	0.238
Schistosoma mansoni	hypothetical protein	0.0387	0.4761	0.4761
Trypanosoma brucei	pyridine nucleotide-disulphide oxidoreductase, putative	0.0074	0.0804	0.077
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0118	0.0118
Loa Loa (eye worm)	beta-lactamase	0.0041	0.0392	0.0392
Trypanosoma cruzi	pyridine nucleotide-disulphide oxidoreductase, putative	0.0074	0.0804	0.077
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.0074	0.0804	0.2293
Toxoplasma gondii	NADPH-glutathione reductase	0.0278	0.3382	0.3382
Plasmodium falciparum	ferrodoxin reductase-like protein	0.0074	0.0804	0.0804
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0278	0.3382	0.3357
Trypanosoma brucei	NADPH:adrenodoxin oxidoreductase, mitochondrial, putative	0.0074	0.0804	0.077
Mycobacterium ulcerans	dehydrogenase	0.0074	0.0804	0.1378
Leishmania major	2,4-dienoyl-coa reductase fadh1, putative	0.0074	0.0804	0.077
Brugia malayi	hypothetical protein	0.0342	0.4186	0.4186
Toxoplasma gondii	ABC1 family protein	0.0041	0.0392	0.0392
Trichomonas vaginalis	apoptosis inducing factor, putative	0.0074	0.0804	0.2293
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0019	0.0019
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0278	0.3382	0.3357
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprA	0.0074	0.0804	0.1378
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0278	0.3382	0.3112
Trichomonas vaginalis	dihydrolipoamide dehydrogenase, putative	0.0074	0.0804	0.2293
Plasmodium falciparum	glutathione reductase	0.0802	1	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0278	0.3382	0.3357
Brugia malayi	ecdysteroid receptor	0.0012	0.0019	0.0019
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0392	0.1061
Loa Loa (eye worm)	animal heme peroxidase	0.009	0.1011	0.1011
Plasmodium vivax	type II NADH:ubiquinone oxidoreductase, putative	0.0074	0.0804	0.0729
Echinococcus multilocularis	sulfide:quinone oxidoreductase	0.0074	0.0804	0.0804
Plasmodium falciparum	thioredoxin reductase	0.0278	0.3382	0.3382
Trypanosoma brucei	2,4-dienoyl-coa reductase-like protein	0.0074	0.0804	0.077
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.0392	0.0392
Brugia malayi	Bloom's syndrome protein homolog	0.0024	0.0181	0.0181
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0074	0.0804	0.0804
Brugia malayi	Animal haem peroxidase family protein	0.009	0.1011	0.1011
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0392	0.0356
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0278	0.3382	0.3357
Schistosoma mansoni	sulfide quinone reductase	0.0074	0.0804	0.0804
Schistosoma mansoni	hypothetical protein	0.0144	0.1689	0.1689
Mycobacterium tuberculosis	Probable reductase	0.0074	0.0804	0.0429
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0392	0.1061
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0074	0.0804	0.2293
Trichomonas vaginalis	glutathione reductase, putative	0.0278	0.3382	1
Echinococcus multilocularis	geminin	0.0387	0.4761	0.4761
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0278	0.3382	0.3112
Brugia malayi	Animal haem peroxidase family protein	0.009	0.1011	0.1011
Trypanosoma cruzi	2,4-dienoyl-coa reductase-like protein, putative	0.0074	0.0804	0.077
Entamoeba histolytica	hypothetical protein, conserved	0.0342	0.4186	1
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0074	0.0804	0.2293
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0278	0.3382	0.3357
Mycobacterium tuberculosis	Probable thioredoxin reductase TrxB2 (TRXR) (TR)	0.0074	0.0804	0.0429
Brugia malayi	NADPH:adrenodoxin oxidoreductase, mitochondrial precursor	0.0074	0.0804	0.0804
Echinococcus granulosus	peroxidasin	0.009	0.1011	0.1011
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.0074	0.0804	0.1849
Toxoplasma gondii	non-proton pumping type-II NADH dehydrogenase I	0.0074	0.0804	0.0804
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0019	0.0019
Trichomonas vaginalis	esterase, putative	0.0041	0.0392	0.1061
Loa Loa (eye worm)	hypothetical protein	0.0362	0.4449	0.4449
Schistosoma mansoni	glutamate synthase	0.0074	0.0804	0.0804
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0278	0.3382	0.3382
Schistosoma mansoni	hypothetical protein	0.0074	0.0804	0.0804
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0278	0.3382	0.3357
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0802	1	1
Onchocerca volvulus	Peroxidase homolog	0.009	0.1011	0.238
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0074	0.0804	0.2293
Loa Loa (eye worm)	RecQ helicase	0.0024	0.0181	0.0181
Echinococcus granulosus	bloom syndrome protein	0.0024	0.0181	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0019	0.0019
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0074	0.0804	0.1378
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0074	0.0804	0.0429
Echinococcus multilocularis	glutamate synthase	0.0074	0.0804	0.0804
Echinococcus multilocularis	protein cereblon	0.0342	0.4186	0.4186
Mycobacterium leprae	THIOREDOXIN TRXC (TRX) (MPT46)	0.0074	0.0804	0.1378
Trypanosoma brucei	NADH dehydrogenase	0.0074	0.0804	0.077
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0019	0.0019
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0019	0.0019
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0278	0.3382	1
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0074	0.0804	0.2293
Plasmodium vivax	NAD(P)H-dependent glutamate synthase, putative	0.0074	0.0804	0.0729
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0278	0.3382	1
Brugia malayi	beta-lactamase family protein	0.0041	0.0392	0.0392
Onchocerca volvulus		0.009	0.1011	0.238
Loa Loa (eye worm)	hypothetical protein	0.009	0.1011	0.1011
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0392	0.1061
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0016	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.009	0.1011	0.1011
Brugia malayi	nuclear hormone receptor	0.0012	0.0019	0.0019
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0075	0.0825	0.0825
Echinococcus granulosus	NADPH:adrenodoxin oxidoreductase	0.0074	0.0804	0.0804
Echinococcus granulosus	geminin	0.0387	0.4761	0.4761
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.009	0.1011	0.1011
Brugia malayi	Thioredoxin reductase	0.0802	1	1
Mycobacterium leprae	Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE)	0.0074	0.0804	0.1378
Toxoplasma gondii	NADH dehydrogenase (NDH2-II)	0.0074	0.0804	0.0804
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0265	0.3214	0.3214
Trichomonas vaginalis	glutamate synthase, putative	0.0074	0.0804	0.2293
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0019	0.0019
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0019	0.0019
Giardia lamblia	Glycerol-3-phosphate dehydrogenase	0.0074	0.0804	0.2378
Mycobacterium ulcerans	glutamate synthase subunit beta	0.0074	0.0804	0.1378
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0019	0.0019
Plasmodium falciparum	thioredoxin reductase	0.0802	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.0804	0.077
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0019	0.0019
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0802	1	1
Trypanosoma cruzi	NADPH:adrenodoxin oxidoreductase, mitochondrial, putative	0.0074	0.0804	0.077
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0019	0.0019
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0278	0.3382	0.3357
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0019	0.0019
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0278	0.3382	0.3382
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0074	0.0804	0.0804
Brugia malayi	steroid hormone receptor	0.0012	0.0019	0.0019
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0019	0.0019
Plasmodium vivax	glutathione reductase, putative	0.0802	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0019	0.0019
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0019	0.0019
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0019	0.0019
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0019	0.0019
Trichomonas vaginalis	mercuric reductase, putative	0.0278	0.3382	1
Leishmania major	trypanothione reductase	0.0802	1	1
Mycobacterium ulcerans	NADH dehydrogenase	0.0074	0.0804	0.1378
Trypanosoma brucei	hypothetical protein, conserved	0.0074	0.0804	0.077
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0392	0.0392
Onchocerca volvulus	Peroxidasin homolog	0.009	0.1011	0.238
Brugia malayi	follicle stimulating hormone receptor	0.0265	0.3214	0.3214
Trypanosoma cruzi	NADH dehydrogenase, putative	0.0074	0.0804	0.077
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0392	0.1061
Onchocerca volvulus	Protein cereblon homolog	0.0342	0.4186	1
Onchocerca volvulus		0.009	0.1011	0.238
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0019	0.0019
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0278	0.3382	0.3382
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0019	0.0019
Giardia lamblia	Glutamate synthase	0.0074	0.0804	0.2378
Echinococcus multilocularis	pyridine nucleotide disulfide oxidoreductase	0.0074	0.0804	0.0804
Plasmodium falciparum	type II NADH:ubiquinone oxidoreductase	0.0074	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.009	0.1011	0.1011
Brugia malayi	hypothetical protein	0.0139	0.1629	0.1629
Mycobacterium ulcerans	thioredoxin reductase TrxB2	0.0074	0.0804	0.1378
Loa Loa (eye worm)	hypothetical protein	0.009	0.1011	0.1011
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0278	0.3382	0.3382
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0019	0.0019
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0278	0.3382	1
Echinococcus granulosus	protein cereblon	0.0342	0.4186	0.4186
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0021	0.0143	0.0143
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0019	0.0019
Leishmania major	hypothetical protein, conserved	0.0041	0.0392	0.0356
Schistosoma mansoni	hypothetical protein	0.0387	0.4761	0.4761
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0278	0.3382	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0019	0.0019
Entamoeba histolytica	NAD(FAD)-dependent dehydrogenase, putative	0.0074	0.0804	0.1849
Loa Loa (eye worm)	thioredoxin reductase	0.0802	1	1
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0074	0.0804	0.0804
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0019	0.0019
Onchocerca volvulus	Peroxidasin homolog	0.009	0.1011	0.238
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0019	0.0019
Entamoeba histolytica	disulphide oxidoreductase, putative	0.0074	0.0804	0.1849
Brugia malayi	Blistered cuticle protein 3	0.009	0.1011	0.1011
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.0392	0.0392
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0075	0.0825	0.0791
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0278	0.3382	0.3357
Mycobacterium tuberculosis	Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase)	0.0074	0.0804	0.0429
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0019	0.0019
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.000000000057866	0.000000000057866
Brugia malayi	beta-lactamase	0.0041	0.0392	0.0392
Brugia malayi	Animal haem peroxidase family protein	0.009	0.1011	0.1011
Trichomonas vaginalis	DNA helicase recq, putative	0.0024	0.0181	0.0429
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0019	0.0019
Echinococcus granulosus	sulfide:quinone oxidoreductase	0.0074	0.0804	0.0804
Echinococcus granulosus	transcription factor Dp 1	0.0044	0.0424	0.0424
Plasmodium falciparum	glutathione reductase	0.0278	0.3382	0.3382
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0075	0.0825	0.0791
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0019	0.0019
Onchocerca volvulus	Chorion peroxidase homolog	0.009	0.1011	0.238
Schistosoma mansoni	thyroid hormone receptor	0.0155	0.1835	0.1835
Mycobacterium ulcerans	ferredoxin reductase	0.0074	0.0804	0.1378
Echinococcus multilocularis	NADPH:adrenodoxin oxidoreductase	0.0074	0.0804	0.0804
Entamoeba histolytica	thioredoxin reductase, putative	0.0074	0.0804	0.1849
Echinococcus granulosus	glutamate synthase	0.0074	0.0804	0.0804
Treponema pallidum	NADH oxidase	0.0278	0.3382	1
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0278	0.3382	0.3357
Onchocerca volvulus		0.0074	0.0804	0.1885
Mycobacterium leprae	PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE)	0.0074	0.0804	0.1378
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0278	0.3382	0.3357
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0278	0.3382	0.3357
Trypanosoma cruzi	NADH dehydrogenase, putative	0.0074	0.0804	0.077
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0278	0.3382	0.3357
Mycobacterium ulcerans	hypothetical protein	0.0074	0.0804	0.1378
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0392	0.0392
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0075	0.0825	0.1899
Brugia malayi	Animal haem peroxidase family protein	0.009	0.1011	0.1011
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0278	0.3382	1
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0144	0.1689	0.1689
Schistosoma mansoni	hypothetical protein	0.0342	0.4186	0.4186
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0074	0.0804	0.0804
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0019	0.0019
Schistosoma mansoni	sulfide quinone reductase	0.0074	0.0804	0.0804
Mycobacterium ulcerans	NADH dehydrogenase Ndh1	0.0074	0.0804	0.1378
Trypanosoma cruzi	trypanothione reductase, putative	0.0802	1	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0074	0.0804	0.0429
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0019	0.0019
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0019	0.0019
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0278	0.3382	0.3357
Schistosoma mansoni	peroxidasin	0.009	0.1011	0.1011
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0019	0.0019
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0019	0.0019
Leishmania major	NADH dehydrogenase, putative	0.0074	0.0804	0.077
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0019	0.0019
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0278	0.3382	0.3357
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0278	0.3382	0.3382
Loa Loa (eye worm)	hypothetical protein	0.009	0.1011	0.1011
Trichomonas vaginalis	glutamate synthase, putative	0.0074	0.0804	0.2293
Brugia malayi	Peroxidasin	0.009	0.1011	0.1011
Loa Loa (eye worm)	glutathione reductase	0.0802	1	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0019	0.0019
Loa Loa (eye worm)	animal heme peroxidase	0.009	0.1011	0.1011
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0019	0.0019
Brugia malayi	beta-lactamase family protein	0.0041	0.0392	0.0392
Schistosoma mansoni	glutamate synthase	0.0074	0.0804	0.0804
Brugia malayi	glutamate synthase	0.0074	0.0804	0.0804
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0075	0.0825	0.0791
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0019	0.0019
Leishmania major	hypothetical protein, conserved	0.0074	0.0804	0.077
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0074	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.009	0.1011	0.1011
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0019	0.0019
Mycobacterium ulcerans	NADPH dependent 2,4-dienoyl-CoA reductase FadH	0.0074	0.0804	0.1378
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0074	0.0804	0.0429
Mycobacterium leprae	Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate	0.0074	0.0804	0.1378
Loa Loa (eye worm)	hypothetical protein	0.0342	0.4186	0.4186
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0019	0.0019
Loa Loa (eye worm)	programmed cell death 8	0.0074	0.0804	0.0804
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0278	0.3382	0.3382
Echinococcus granulosus	apoptosis inducing factor 1 mitochondrial	0.0074	0.0804	0.0804
Echinococcus granulosus	pyridine nucleotide disulfide oxidoreductase	0.0074	0.0804	0.0804
Plasmodium vivax	thioredoxin reductase, putative	0.0802	1	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0392	0.0392
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.009	0.1011	0.1011
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0074	0.0804	0.2293
Echinococcus multilocularis	transcription factor Dp 1	0.0044	0.0424	0.0424
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0278	0.3382	0.3357
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0278	0.3382	1
Onchocerca volvulus	Dual oxidase homolog	0.009	0.1011	0.238
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0392	0.0392
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0074	0.0804	0.2293
Giardia lamblia	Thioredoxin reductase	0.0074	0.0804	0.2378
Schistosoma mansoni	peroxidasin	0.009	0.1011	0.1011
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0278	0.3382	1
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0075	0.0825	0.0825
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0074	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.009	0.1011	0.1011
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0392	0.0392
Schistosoma mansoni	blooms syndrome DNA helicase	0.0019	0.0116	0.0116
Mycobacterium tuberculosis	Probable oxidoreductase	0.0278	0.3382	0.3112
Trypanosoma cruzi	2,4-dienoyl-coa reductase fadh1, putative	0.0074	0.0804	0.077
Loa Loa (eye worm)	hypothetical protein	0.009	0.1011	0.1011
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0019	0.0019
Onchocerca volvulus		0.0041	0.0392	0.0896
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0074	0.0804	0.0804
Mycobacterium tuberculosis	NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase)	0.0074	0.0804	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0019	0.0019
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0278	0.3382	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0263	0.3191	0.2913
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0392	0.0392
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0074	0.0804	0.0429
Toxoplasma gondii	thioredoxin reductase	0.0802	1	1
Mycobacterium tuberculosis	Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase)	0.0074	0.0804	0.0429
Toxoplasma gondii	selenide, water dikinase	0.0074	0.0804	0.0804
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0075	0.0825	0.0825
Onchocerca volvulus		0.0041	0.0392	0.0896
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0075	0.0825	0.0825
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.0392	0.0392
Loa Loa (eye worm)	hypothetical protein	0.009	0.1011	0.1011
Trypanosoma brucei	pyridine nucleotide-disulphide oxidoreductase, putative	0.0074	0.0804	0.077
Loa Loa (eye worm)	hypothetical protein	0.009	0.1011	0.1011
Schistosoma mansoni	glutamate synthase	0.0074	0.0804	0.0804
Plasmodium falciparum	NAD(P)H-dependent glutamate synthase, putative	0.0074	0.0804	0.0804
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0019	0.0019
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0155	0.1835	0.1835
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0019	0.0019
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0019	0.0019
Entamoeba histolytica	glutamate synthase beta subunit, putative	0.0074	0.0804	0.1849
Onchocerca volvulus	Peroxidase homolog	0.009	0.1011	0.238
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0075	0.0825	0.0791
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0804	0.0804
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0278	0.3382	0.3357
Entamoeba histolytica	pyridine nucleotide-disulfide oxidoreductase family protein	0.0074	0.0804	0.1849
Echinococcus multilocularis	bloom syndrome protein	0.0024	0.0181	0.0181
Loa Loa (eye worm)	pyridine nucleotide-disufhide oxidoreductase	0.0074	0.0804	0.0804
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0392	0.0314
Entamoeba histolytica	glutamate synthase beta subunit, putative	0.0074	0.0804	0.1849
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0019	0.0019
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0278	0.3382	0.3328
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0019	0.0019
Mycobacterium ulcerans	monoxygenase	0.0074	0.0804	0.1378
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0278	0.3382	0.3382
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0392	0.0356
Loa Loa (eye worm)	animal heme peroxidase	0.009	0.1011	0.1011
Echinococcus granulosus	thioredoxin glutathione reductase	0.0802	1	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.1011	0.1011
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0392	0.1061
Trichomonas vaginalis	DNA helicase recq1, putative	0.0024	0.0181	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0019	0.0019
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0019	0.0019
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0278	0.3382	0.3357
Leishmania major	hypothetical protein, conserved	0.0074	0.0804	0.077
Mycobacterium ulcerans	NADH dehydrogenase Ndh	0.0074	0.0804	0.1378
Brugia malayi	Animal haem peroxidase family protein	0.009	0.1011	0.1011
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0278	0.3382	0.3112
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0019	0.0019
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0392	0.0392
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0019	0.0019

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3500763

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2076172