Detailed information for compound 2076173

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 431.433 | Formula: C17H20F3N5O3S
  • H donors: 2 H acceptors: 5 LogP: -0.41 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(F)(F)F.O=C(c1n[nH]c2c1CCN(C2)Cc1nccs1)N1CCCC1
  • InChi: 1S/C15H19N5OS.C2HF3O2/c21-15(20-5-1-2-6-20)14-11-3-7-19(9-12(11)17-18-14)10-13-16-4-8-22-13;3-2(4,5)1(6)7/h4,8H,1-3,5-7,9-10H2,(H,17,18);(H,6,7)
  • InChiKey: VWPQKJAEJAGLHM-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi Animal haem peroxidase family protein 0.0484 0.5987 0.5987
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0074 0.0804 0.077
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0074 0.0804 0.1378
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.0804 0.2293
Schistosoma mansoni peroxidasin 0.0484 0.5987 0.5987
Plasmodium falciparum ferrodoxin reductase-like protein 0.0074 0.0804 0.0804
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0074 0.0804 0.077
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0074 0.0804 0.077
Brugia malayi Peroxidasin 0.0484 0.5987 0.5987
Loa Loa (eye worm) hypothetical protein 0.0019 0.0118 0.0118
Loa Loa (eye worm) beta-lactamase 0.0041 0.0392 0.0392
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0278 0.3382 0.3357
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0019 0.0019
Trichomonas vaginalis glutamate synthase, putative 0.0074 0.0804 0.2293
Schistosoma mansoni disulfide oxidoreductase 0.0074 0.0804 0.0804
Trypanosoma cruzi trypanothione reductase, putative 0.0278 0.3382 0.3357
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0074 0.0804 0.0729
Mycobacterium ulcerans hypothetical protein 0.0074 0.0804 0.1378
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0392 0.1061
Plasmodium falciparum glutathione reductase 0.0802 1 1
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Brugia malayi ecdysteroid receptor 0.0012 0.0019 0.0019
Mycobacterium ulcerans dehydrogenase 0.0074 0.0804 0.1378
Onchocerca volvulus Protein cereblon homolog 0.0342 0.4186 0.6982
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0074 0.0804 0.2293
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0074 0.0804 0.0804
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0019 0.0019
Onchocerca volvulus Dual oxidase homolog 0.0484 0.5987 1
Toxoplasma gondii ABC1 family protein 0.0041 0.0392 0.0392
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0074 0.0804 0.077
Onchocerca volvulus Peroxidasin homolog 0.0484 0.5987 1
Schistosoma mansoni sulfide quinone reductase 0.0074 0.0804 0.0804
Schistosoma mansoni hypothetical protein 0.0144 0.1689 0.1689
Echinococcus multilocularis protein cereblon 0.0342 0.4186 0.4186
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0392 0.0356
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0074 0.0804 0.1378
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0074 0.0804 0.077
Onchocerca volvulus Peroxidase homolog 0.0484 0.5987 1
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0181 0.0181
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0392 0.0392
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0074 0.0804 0.0804
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0144 0.1689 0.1689
Loa Loa (eye worm) animal heme peroxidase 0.0484 0.5987 0.5987
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0074 0.0804 0.0429
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0074 0.0804 0.0804
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0204 0.2451 0.2451
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0074 0.0804 0.077
Brugia malayi hypothetical protein 0.0484 0.5987 0.5987
Brugia malayi Animal haem peroxidase family protein 0.0484 0.5987 0.5987
Schistosoma mansoni hypothetical protein 0.0387 0.4761 0.4761
Echinococcus multilocularis glutamate synthase 0.0074 0.0804 0.0804
Mycobacterium tuberculosis Probable reductase 0.0074 0.0804 0.0429
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0392 0.1061
Trichomonas vaginalis glutathione reductase, putative 0.0278 0.3382 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0278 0.3382 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0019 0.0019
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.0804 0.2293
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0019 0.0019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.3382 0.3357
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0019 0.0019
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0074 0.0804 0.0804
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0074 0.0804 0.0429
Trichomonas vaginalis apoptosis inducing factor, putative 0.0074 0.0804 0.2293
Onchocerca volvulus 0.0041 0.0392 0.0626
Loa Loa (eye worm) hypothetical protein 0.0041 0.0392 0.0392
Leishmania major hypothetical protein, conserved 0.0074 0.0804 0.077
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0019 0.0019
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0392 0.0356
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0074 0.0804 0.1378
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0074 0.0804 0.077
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0278 0.3382 0.3382
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0074 0.0804 0.0804
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0074 0.0804 0.1378
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0074 0.0804 0.0429
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0804 0.077
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0019 0.0019
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0802 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0019 0.0019
Schistosoma mansoni coup transcription factor 0.0012 0.0019 0.0019
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0278 0.3382 0.3328
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0265 0.3214 0.3214
Plasmodium vivax ferrodoxin reductase, putative 0.0074 0.0804 0.0729
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0074 0.0804 0.077
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0278 0.3382 0.3112
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0278 0.3382 0.3382
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0278 0.3382 0.3357
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0075 0.0825 0.1899
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0074 0.0804 0.2293
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0392 0.0392
Mycobacterium tuberculosis Probable oxidoreductase 0.0278 0.3382 0.3112
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0019 0.0019
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0019 0.0019
Onchocerca volvulus 0.0074 0.0804 0.1317
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0278 0.3382 0.3382
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0074 0.0804 0.0804
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0074 0.0804 0.2293
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0019 0.0019
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0074 0.0804 0.1378
Loa Loa (eye worm) thioredoxin reductase 0.0802 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0019 0.0019
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0278 0.3382 0.3112
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Brugia malayi nuclear receptor NHR-88 0.0012 0.0019 0.0019
Brugia malayi Animal haem peroxidase family protein 0.0484 0.5987 0.5987
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0019 0.0019
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0074 0.0804 0.077
Leishmania major trypanothione reductase 0.0802 1 1
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0019 0.0019
Echinococcus granulosus thioredoxin glutathione reductase 0.0802 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0804 0.077
Mycobacterium ulcerans NADH dehydrogenase 0.0074 0.0804 0.1378
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0019 0.0019
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0392 0.0392
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0278 0.3382 1
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0804 0.077
Mycobacterium ulcerans glutamate synthase subunit beta 0.0074 0.0804 0.1378
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Plasmodium vivax thioredoxin reductase, putative 0.0802 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0019 0.0019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0019 0.0019
Brugia malayi steroid hormone receptor 0.0012 0.0019 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0019 0.0019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0019 0.0019
Trypanosoma brucei trypanothione reductase 0.0802 1 1
Entamoeba histolytica hypothetical protein, conserved 0.0342 0.4186 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0074 0.0804 0.0804
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.0804 0.2293
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0019 0.0019
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0074 0.0804 0.0804
Treponema pallidum NADH oxidase 0.0278 0.3382 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0278 0.3382 0.3357
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0019 0.0019
Loa Loa (eye worm) blistered cuticle protein 3 0.0484 0.5987 0.5987
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0392 0.1061
Trypanosoma cruzi NADH dehydrogenase, putative 0.0074 0.0804 0.077
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0278 0.3382 1
Brugia malayi Animal haem peroxidase family protein 0.0484 0.5987 0.5987
Trichomonas vaginalis esterase, putative 0.0041 0.0392 0.1061
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0019 0.0019
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0074 0.0804 0.0804
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0074 0.0804 0.0804
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0074 0.0804 0.2293
Loa Loa (eye worm) RecQ helicase 0.0024 0.0181 0.0181
Echinococcus granulosus bloom syndrome protein 0.0024 0.0181 0.0181
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0204 0.2451 0.2451
Brugia malayi Thioredoxin reductase 0.0802 1 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0278 0.3382 0.3382
Plasmodium falciparum glutathione reductase 0.0278 0.3382 0.3382
Schistosoma mansoni hypothetical protein 0.0074 0.0804 0.0804
Schistosoma mansoni glutamate synthase 0.0074 0.0804 0.0804
Onchocerca volvulus 0.0484 0.5987 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0019 0.0019
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0074 0.0804 0.0804
Trypanosoma brucei NADH dehydrogenase 0.0074 0.0804 0.077
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0074 0.0804 0.1378
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0074 0.0804 0.0429
Trichomonas vaginalis glutamate synthase, putative 0.0074 0.0804 0.2293
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0074 0.0804 0.1378
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0825 0.0791
Giardia lamblia Glutamate synthase 0.0074 0.0804 0.2378
Echinococcus multilocularis thyroid hormone receptor alpha 0.0155 0.1835 0.1835
Brugia malayi nuclear hormone receptor 0.0012 0.0019 0.0019
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0079 0.0079
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0392 0.1061
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0278 0.3382 0.3357
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0278 0.3382 0.3112
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0074 0.0804 0.0729
Brugia malayi beta-lactamase family protein 0.0041 0.0392 0.0392
Loa Loa (eye worm) animal heme peroxidase 0.0484 0.5987 0.5987
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0278 0.3382 0.3328
Onchocerca volvulus Peroxidasin homolog 0.0484 0.5987 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0144 0.1689 0.1689
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0075 0.0825 0.0825
Loa Loa (eye worm) hypothetical protein 0.0342 0.4186 0.4186
Loa Loa (eye worm) hypothetical protein 0.0041 0.0392 0.0392
Trypanosoma cruzi NADH dehydrogenase, putative 0.0074 0.0804 0.077
Onchocerca volvulus Peroxidase homolog 0.0484 0.5987 1
Loa Loa (eye worm) programmed cell death 8 0.0074 0.0804 0.0804
Brugia malayi hypothetical protein 0.0342 0.4186 0.4186
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0074 0.0804 0.1849
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0074 0.0804 0.1378
Schistosoma mansoni hypothetical protein 0.0342 0.4186 0.4186
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0074 0.0804 0.1849
Echinococcus granulosus peroxidasin 0.0484 0.5987 0.5987
Entamoeba histolytica thioredoxin reductase, putative 0.0074 0.0804 0.1849
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0263 0.3191 0.2913
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0019 0.0019
Echinococcus multilocularis geminin 0.0387 0.4761 0.4761
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0074 0.0804 0.0429
Schistosoma mansoni sulfide quinone reductase 0.0074 0.0804 0.0804
Loa Loa (eye worm) hypothetical protein 0.0074 0.0804 0.0804
Plasmodium vivax glutathione reductase, putative 0.0802 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0019 0.0019
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0074 0.0804 0.0804
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0019 0.0019
Brugia malayi beta-lactamase family protein 0.0041 0.0392 0.0392
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0019 0.0019
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0278 0.3382 0.3357
Echinococcus multilocularis thioredoxin glutathione reductase 0.0802 1 1
Brugia malayi hypothetical protein 0.0139 0.1629 0.1629
Mycobacterium tuberculosis Probable dehydrogenase 0.0074 0.0804 0.0429
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0278 0.3382 0.3357
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0019 0.0019
Onchocerca volvulus 0.0484 0.5987 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0019 0.0019
Leishmania major NADH dehydrogenase, putative 0.0074 0.0804 0.077
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0019 0.0019
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0019 0.0019
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0074 0.0804 0.1378
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0074 0.0804 0.0429
Mycobacterium ulcerans ferredoxin reductase 0.0074 0.0804 0.1378
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.3382 0.3357
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0019 0.0019
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0074 0.0804 0.0804
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0019 0.0019
Leishmania major hypothetical protein, conserved 0.0074 0.0804 0.077
Brugia malayi glutamate synthase 0.0074 0.0804 0.0804
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0075 0.0825 0.0825
Schistosoma mansoni glutamate synthase 0.0074 0.0804 0.0804
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0278 0.3382 1
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0074 0.0804 0.1378
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0278 0.3382 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0278 0.3382 1
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0074 0.0804 0.0804
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0074 0.0804 0.0804
Schistosoma mansoni thyroid hormone receptor 0.0155 0.1835 0.1835
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0278 0.3382 0.3357
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0074 0.0804 0.0804
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0019 0.0019
Entamoeba histolytica disulphide oxidoreductase, putative 0.0074 0.0804 0.1849
Plasmodium falciparum thioredoxin reductase 0.0802 1 1
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0019 0.0019
Loa Loa (eye worm) animal heme peroxidase 0.0484 0.5987 0.5987
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0143 0.0143
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0019 0.0019
Loa Loa (eye worm) animal heme peroxidase 0.0484 0.5987 0.5987
Leishmania major hypothetical protein, conserved 0.0041 0.0392 0.0356
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Onchocerca volvulus 0.0484 0.5987 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0181 0.0429
Brugia malayi follicle stimulating hormone receptor 0.0265 0.3214 0.3214
Brugia malayi beta-lactamase 0.0041 0.0392 0.0392
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.000000000057866 0.000000000057866
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0019 0.0019
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0074 0.0804 0.0429
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0392 0.0392
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0825 0.0791
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0074 0.0804 0.1378
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0074 0.0804 0.1849
Toxoplasma gondii NADPH-glutathione reductase 0.0278 0.3382 0.3382
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.3382 0.3357
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0019 0.0019
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0074 0.0804 0.0804
Echinococcus granulosus transcription factor Dp 1 0.0044 0.0424 0.0424
Brugia malayi Animal haem peroxidase family protein 0.0484 0.5987 0.5987
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0075 0.0825 0.0791
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0019 0.0019
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0074 0.0804 0.077
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.3382 0.3357
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0392 0.0392
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0825 0.0791
Onchocerca volvulus 0.0041 0.0392 0.0626
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0074 0.0804 0.0429
Loa Loa (eye worm) glutathione reductase 0.0802 1 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0075 0.0825 0.0825
Toxoplasma gondii selenide, water dikinase 0.0074 0.0804 0.0804
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0075 0.0825 0.0825
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0074 0.0804 0.0804
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0278 0.3382 1
Giardia lamblia Thioredoxin reductase 0.0074 0.0804 0.2378
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0019 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0019 0.0019
Trichomonas vaginalis mercuric reductase, putative 0.0278 0.3382 1
Schistosoma mansoni glutamate synthase 0.0074 0.0804 0.0804
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0074 0.0804 0.0804
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0019 0.0019
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0278 0.3382 0.3357
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0278 0.3382 0.3357
Toxoplasma gondii thioredoxin reductase 0.0802 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0392 0.0356
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0278 0.3382 0.3382
Brugia malayi Blistered cuticle protein 3 0.0484 0.5987 0.5987
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Echinococcus multilocularis peroxidasin 0.0484 0.5987 0.5987
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0074 0.0804 0.1378
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0392 0.0314
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0074 0.0804 0.1849
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0181 0.0181
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.0804 0.2293
Echinococcus granulosus protein cereblon 0.0342 0.4186 0.4186
Echinococcus granulosus glutamate synthase 0.0074 0.0804 0.0804
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0019 0.0019
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0392 0.0392
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0019 0.0019
Mycobacterium ulcerans monoxygenase 0.0074 0.0804 0.1378
Leishmania major hypothetical protein, conserved 0.0074 0.0804 0.077
Loa Loa (eye worm) hypothetical protein 0.0362 0.4449 0.4449
Schistosoma mansoni thyroid hormone receptor 0.0155 0.1835 0.1835
Echinococcus granulosus geminin 0.0387 0.4761 0.4761
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0181 0.0429
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0392 0.1061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0019 0.0019
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0278 0.3382 0.3357
Loa Loa (eye worm) hypothetical protein 0.0041 0.0392 0.0392
Trypanosoma cruzi trypanothione reductase, putative 0.0802 1 1
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0074 0.0804 0.0804
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0074 0.0804 0.2378
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0074 0.0804 0.0804
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0074 0.0804 0.1849
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.3382 0.3357
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.0804 0.2293
Loa Loa (eye worm) hypothetical protein 0.0041 0.0392 0.0392
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0278 0.3382 0.3382
Onchocerca volvulus Chorion peroxidase homolog 0.0484 0.5987 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0278 0.3382 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.0804 0.2293
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.0424 0.0424
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0019 0.0019
Onchocerca volvulus 0.0041 0.0392 0.0626
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0074 0.0804 0.077
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0278 0.3382 0.3382
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0116 0.0116
Schistosoma mansoni hypothetical protein 0.0387 0.4761 0.4761
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0074 0.0804 0.0804
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0075 0.0825 0.0825
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.3382 0.3357
Loa Loa (eye worm) hypothetical protein 0.0041 0.0392 0.0392
Schistosoma mansoni peroxidasin 0.0484 0.5987 0.5987
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0074 0.0804 0.0429
Loa Loa (eye worm) hypothetical protein 0.0041 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Plasmodium falciparum thioredoxin reductase 0.0278 0.3382 0.3382
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0074 0.0804 0.0429
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0074 0.0804 0.0804

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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