Detailed information for compound 2076173

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 431.433 | Formula: C17H20F3N5O3S
  • H donors: 2 H acceptors: 5 LogP: -0.41 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(F)(F)F.O=C(c1n[nH]c2c1CCN(C2)Cc1nccs1)N1CCCC1
  • InChi: 1S/C15H19N5OS.C2HF3O2/c21-15(20-5-1-2-6-20)14-11-3-7-19(9-12(11)17-18-14)10-13-16-4-8-22-13;3-2(4,5)1(6)7/h4,8H,1-3,5-7,9-10H2,(H,17,18);(H,6,7)
  • InChiKey: VWPQKJAEJAGLHM-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0074 0.0804 0.0429
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0074 0.0804 0.1378
Mycobacterium ulcerans hypothetical protein 0.0074 0.0804 0.1378
Loa Loa (eye worm) animal heme peroxidase 0.0484 0.5987 0.5987
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0019 0.0019
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0278 0.3382 0.3328
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0802 1 1
Brugia malayi beta-lactamase 0.0041 0.0392 0.0392
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0392 0.0392
Schistosoma mansoni thyroid hormone receptor 0.0155 0.1835 0.1835
Trichomonas vaginalis apoptosis inducing factor, putative 0.0074 0.0804 0.2293
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0019 0.0019
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0074 0.0804 0.077
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0074 0.0804 0.077
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0074 0.0804 0.1378
Echinococcus granulosus glutamate synthase 0.0074 0.0804 0.0804
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0019 0.0019
Plasmodium falciparum glutathione reductase 0.0802 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0019 0.0019
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0074 0.0804 0.1378
Onchocerca volvulus Protein cereblon homolog 0.0342 0.4186 0.6982
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0278 0.3382 0.3357
Echinococcus granulosus geminin 0.0387 0.4761 0.4761
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0074 0.0804 0.1849
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0075 0.0825 0.1899
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0019 0.0019
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0074 0.0804 0.1378
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0019 0.0019
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0074 0.0804 0.0729
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.3382 0.3357
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0143 0.0143
Mycobacterium ulcerans NADH dehydrogenase 0.0074 0.0804 0.1378
Mycobacterium ulcerans glutamate synthase subunit beta 0.0074 0.0804 0.1378
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0074 0.0804 0.0804
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0392 0.0314
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Onchocerca volvulus Dual oxidase homolog 0.0484 0.5987 1
Plasmodium vivax thioredoxin reductase, putative 0.0802 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0392 0.0392
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0075 0.0825 0.0825
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0019 0.0019
Trichomonas vaginalis mercuric reductase, putative 0.0278 0.3382 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0278 0.3382 0.3382
Onchocerca volvulus Chorion peroxidase homolog 0.0484 0.5987 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0278 0.3382 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0278 0.3382 0.3357
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0019 0.0019
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0074 0.0804 0.0429
Echinococcus multilocularis thyroid hormone receptor alpha 0.0155 0.1835 0.1835
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0278 0.3382 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0075 0.0825 0.0825
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.3382 0.3357
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0019 0.0019
Brugia malayi Animal haem peroxidase family protein 0.0484 0.5987 0.5987
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.3382 0.3357
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0019 0.0019
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0074 0.0804 0.0804
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0079 0.0079
Schistosoma mansoni hypothetical protein 0.0144 0.1689 0.1689
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0804 0.077
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0019 0.0019
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0144 0.1689 0.1689
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0019 0.0019
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0392 0.0392
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Schistosoma mansoni sulfide quinone reductase 0.0074 0.0804 0.0804
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0074 0.0804 0.1849
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0278 0.3382 0.3112
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0074 0.0804 0.0804
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.0804 0.2293
Mycobacterium ulcerans monoxygenase 0.0074 0.0804 0.1378
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0019 0.0019
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0074 0.0804 0.2293
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0019 0.0019
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0074 0.0804 0.0429
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0074 0.0804 0.0429
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0204 0.2451 0.2451
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0019 0.0019
Onchocerca volvulus 0.0041 0.0392 0.0626
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0825 0.0791
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0019 0.0019
Schistosoma mansoni glutamate synthase 0.0074 0.0804 0.0804
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Trichomonas vaginalis glutathione reductase, putative 0.0278 0.3382 1
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0074 0.0804 0.2293
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.3382 0.3357
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0019 0.0019
Leishmania major hypothetical protein, conserved 0.0074 0.0804 0.077
Schistosoma mansoni glutamate synthase 0.0074 0.0804 0.0804
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0392 0.0356
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0074 0.0804 0.1378
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0074 0.0804 0.0804
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0278 0.3382 0.3328
Mycobacterium ulcerans dehydrogenase 0.0074 0.0804 0.1378
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0074 0.0804 0.0804
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.0424 0.0424
Echinococcus granulosus bloom syndrome protein 0.0024 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0392 0.1061
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0278 0.3382 0.3382
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0392 0.1061
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0804 0.077
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0074 0.0804 0.0804
Giardia lamblia Glutamate synthase 0.0074 0.0804 0.2378
Entamoeba histolytica hypothetical protein, conserved 0.0342 0.4186 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0074 0.0804 0.0429
Loa Loa (eye worm) hypothetical protein 0.0041 0.0392 0.0392
Echinococcus multilocularis peroxidasin 0.0484 0.5987 0.5987
Schistosoma mansoni hypothetical protein 0.0387 0.4761 0.4761
Leishmania major hypothetical protein, conserved 0.0041 0.0392 0.0356
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0019 0.0019
Brugia malayi hypothetical protein 0.0484 0.5987 0.5987
Loa Loa (eye worm) animal heme peroxidase 0.0484 0.5987 0.5987
Entamoeba histolytica disulphide oxidoreductase, putative 0.0074 0.0804 0.1849
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0074 0.0804 0.1849
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0074 0.0804 0.0429
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0392 0.0356
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0074 0.0804 0.1378
Plasmodium vivax ferrodoxin reductase, putative 0.0074 0.0804 0.0729
Giardia lamblia NADH oxidase lateral transfer candidate 0.0278 0.3382 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0019 0.0019
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0392 0.0392
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0074 0.0804 0.1378
Loa Loa (eye worm) hypothetical protein 0.0074 0.0804 0.0804
Entamoeba histolytica thioredoxin reductase, putative 0.0074 0.0804 0.1849
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.3382 0.3357
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0825 0.0791
Plasmodium falciparum thioredoxin reductase 0.0802 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0019 0.0019
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0074 0.0804 0.0804
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0019 0.0019
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0074 0.0804 0.0429
Trypanosoma brucei trypanothione reductase 0.0802 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0019 0.0019
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0074 0.0804 0.0429
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0019 0.0019
Brugia malayi Thioredoxin reductase 0.0802 1 1
Brugia malayi Animal haem peroxidase family protein 0.0484 0.5987 0.5987
Leishmania major hypothetical protein, conserved 0.0074 0.0804 0.077
Loa Loa (eye worm) hypothetical protein 0.0041 0.0392 0.0392
Echinococcus multilocularis geminin 0.0387 0.4761 0.4761
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0019 0.0019
Schistosoma mansoni thyroid hormone receptor 0.0155 0.1835 0.1835
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.000000000057866 0.000000000057866
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0278 0.3382 0.3357
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0019 0.0019
Brugia malayi Animal haem peroxidase family protein 0.0484 0.5987 0.5987
Echinococcus granulosus transcription factor Dp 1 0.0044 0.0424 0.0424
Loa Loa (eye worm) hypothetical protein 0.0362 0.4449 0.4449
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0074 0.0804 0.1378
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0074 0.0804 0.0804
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0074 0.0804 0.0804
Loa Loa (eye worm) blistered cuticle protein 3 0.0484 0.5987 0.5987
Plasmodium falciparum glutathione reductase 0.0278 0.3382 0.3382
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0278 0.3382 0.3357
Mycobacterium tuberculosis Probable oxidoreductase 0.0278 0.3382 0.3112
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0181 0.0181
Loa Loa (eye worm) animal heme peroxidase 0.0484 0.5987 0.5987
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0074 0.0804 0.0804
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0019 0.0019
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0019 0.0019
Mycobacterium ulcerans ferredoxin reductase 0.0074 0.0804 0.1378
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0074 0.0804 0.2293
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0019 0.0019
Brugia malayi beta-lactamase family protein 0.0041 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0019 0.0019
Onchocerca volvulus Peroxidasin homolog 0.0484 0.5987 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0019 0.0019
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0278 0.3382 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0019 0.0019
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0074 0.0804 0.077
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0074 0.0804 0.077
Schistosoma mansoni coup transcription factor 0.0012 0.0019 0.0019
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0074 0.0804 0.0804
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0181 0.0429
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.3382 0.3357
Loa Loa (eye worm) hypothetical protein 0.0041 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Brugia malayi beta-lactamase family protein 0.0041 0.0392 0.0392
Onchocerca volvulus 0.0484 0.5987 1
Schistosoma mansoni disulfide oxidoreductase 0.0074 0.0804 0.0804
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0019 0.0019
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0392 0.1061
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Brugia malayi Animal haem peroxidase family protein 0.0484 0.5987 0.5987
Brugia malayi nuclear hormone receptor 0.0012 0.0019 0.0019
Toxoplasma gondii selenide, water dikinase 0.0074 0.0804 0.0804
Trypanosoma cruzi trypanothione reductase, putative 0.0802 1 1
Toxoplasma gondii ABC1 family protein 0.0041 0.0392 0.0392
Trichomonas vaginalis esterase, putative 0.0041 0.0392 0.1061
Brugia malayi hypothetical protein 0.0342 0.4186 0.4186
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0074 0.0804 0.1849
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0278 0.3382 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0278 0.3382 0.3357
Brugia malayi follicle stimulating hormone receptor 0.0265 0.3214 0.3214
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0075 0.0825 0.0791
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0074 0.0804 0.077
Echinococcus multilocularis protein cereblon 0.0342 0.4186 0.4186
Loa Loa (eye worm) animal heme peroxidase 0.0484 0.5987 0.5987
Plasmodium vivax glutathione reductase, putative 0.0802 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0019 0.0019
Onchocerca volvulus Peroxidase homolog 0.0484 0.5987 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0019 0.0019
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0074 0.0804 0.0804
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0278 0.3382 0.3357
Echinococcus granulosus protein cereblon 0.0342 0.4186 0.4186
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0041 0.0392 0.0392
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0116 0.0116
Treponema pallidum NADH oxidase 0.0278 0.3382 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0392 0.0392
Plasmodium falciparum thioredoxin reductase 0.0278 0.3382 0.3382
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0074 0.0804 0.0729
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0074 0.0804 0.077
Schistosoma mansoni peroxidasin 0.0484 0.5987 0.5987
Leishmania major trypanothione reductase 0.0802 1 1
Loa Loa (eye worm) glutathione reductase 0.0802 1 1
Brugia malayi ecdysteroid receptor 0.0012 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0019 0.0019
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0278 0.3382 0.3357
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0074 0.0804 0.0429
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0019 0.0019
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0181 0.0181
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.0804 0.2293
Leishmania major NADH dehydrogenase, putative 0.0074 0.0804 0.077
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0074 0.0804 0.0804
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0019 0.0019
Echinococcus granulosus thioredoxin glutathione reductase 0.0802 1 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0074 0.0804 0.0804
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0204 0.2451 0.2451
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0278 0.3382 1
Brugia malayi Peroxidasin 0.0484 0.5987 0.5987
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0392 0.0356
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0074 0.0804 0.0804
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Schistosoma mansoni hypothetical protein 0.0387 0.4761 0.4761
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0019 0.0019
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0074 0.0804 0.2378
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0278 0.3382 0.3357
Loa Loa (eye worm) hypothetical protein 0.0041 0.0392 0.0392
Brugia malayi Blistered cuticle protein 3 0.0484 0.5987 0.5987
Giardia lamblia Thioredoxin reductase 0.0074 0.0804 0.2378
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0144 0.1689 0.1689
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0278 0.3382 0.3382
Brugia malayi nuclear receptor NHR-88 0.0012 0.0019 0.0019
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0074 0.0804 0.1378
Loa Loa (eye worm) hypothetical protein 0.0019 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0342 0.4186 0.4186
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.0804 0.2293
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0074 0.0804 0.1378
Trypanosoma brucei NADH dehydrogenase 0.0074 0.0804 0.077
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0074 0.0804 0.0804
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0263 0.3191 0.2913
Echinococcus multilocularis glutamate synthase 0.0074 0.0804 0.0804
Schistosoma mansoni sulfide quinone reductase 0.0074 0.0804 0.0804
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0278 0.3382 1
Onchocerca volvulus 0.0484 0.5987 1
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0074 0.0804 0.0804
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0278 0.3382 0.3382
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Schistosoma mansoni hypothetical protein 0.0342 0.4186 0.4186
Trichomonas vaginalis glutamate synthase, putative 0.0074 0.0804 0.2293
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0074 0.0804 0.0804
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0074 0.0804 0.077
Brugia malayi glutamate synthase 0.0074 0.0804 0.0804
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0074 0.0804 0.0429
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0074 0.0804 0.077
Plasmodium falciparum ferrodoxin reductase-like protein 0.0074 0.0804 0.0804
Brugia malayi steroid hormone receptor 0.0012 0.0019 0.0019
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0278 0.3382 0.3382
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0019 0.0019
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.0804 0.2293
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0278 0.3382 0.3112
Echinococcus multilocularis thioredoxin glutathione reductase 0.0802 1 1
Brugia malayi Animal haem peroxidase family protein 0.0484 0.5987 0.5987
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0278 0.3382 0.3382
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0074 0.0804 0.077
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0278 0.3382 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.0804 0.2293
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0074 0.0804 0.0804
Toxoplasma gondii NADPH-glutathione reductase 0.0278 0.3382 0.3382
Echinococcus granulosus peroxidasin 0.0484 0.5987 0.5987
Mycobacterium tuberculosis Probable reductase 0.0074 0.0804 0.0429
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0074 0.0804 0.077
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0019 0.0019
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.0804 0.2293
Loa Loa (eye worm) RecQ helicase 0.0024 0.0181 0.0181
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0019 0.0019
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0074 0.0804 0.2293
Brugia malayi hypothetical protein 0.0139 0.1629 0.1629
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0074 0.0804 0.1378
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0019 0.0019
Onchocerca volvulus Peroxidasin homolog 0.0484 0.5987 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0278 0.3382 0.3357
Onchocerca volvulus Peroxidase homolog 0.0484 0.5987 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0074 0.0804 0.0804
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0278 0.3382 0.3382
Trichomonas vaginalis glutamate synthase, putative 0.0074 0.0804 0.2293
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0074 0.0804 0.0804
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0075 0.0825 0.0825
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0825 0.0791
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0074 0.0804 0.077
Loa Loa (eye worm) programmed cell death 8 0.0074 0.0804 0.0804
Toxoplasma gondii thioredoxin reductase 0.0802 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0804 0.077
Schistosoma mansoni peroxidasin 0.0484 0.5987 0.5987
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0278 0.3382 0.3112
Onchocerca volvulus 0.0041 0.0392 0.0626
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0075 0.0825 0.0825
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0392 0.1061
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0265 0.3214 0.3214
Onchocerca volvulus 0.0041 0.0392 0.0626
Leishmania major hypothetical protein, conserved 0.0074 0.0804 0.077
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0019 0.0019
Schistosoma mansoni glutamate synthase 0.0074 0.0804 0.0804
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0074 0.0804 0.1849
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0074 0.0804 0.0804
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0074 0.0804 0.0429
Loa Loa (eye worm) hypothetical protein 0.0041 0.0392 0.0392
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0074 0.0804 0.1378
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0075 0.0825 0.0825
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0074 0.0804 0.0804
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0278 0.3382 0.3357
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0181 0.0429
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0392 0.1061
Schistosoma mansoni hypothetical protein 0.0074 0.0804 0.0804
Trypanosoma cruzi NADH dehydrogenase, putative 0.0074 0.0804 0.077
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0019 0.0019
Loa Loa (eye worm) beta-lactamase 0.0041 0.0392 0.0392
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0392 0.0392
Loa Loa (eye worm) thioredoxin reductase 0.0802 1 1
Onchocerca volvulus 0.0484 0.5987 1
Trypanosoma cruzi NADH dehydrogenase, putative 0.0074 0.0804 0.077
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0019 0.0019
Trypanosoma cruzi trypanothione reductase, putative 0.0278 0.3382 0.3357
Loa Loa (eye worm) hypothetical protein 0.0484 0.5987 0.5987
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0019 0.0019
Onchocerca volvulus 0.0074 0.0804 0.1317
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0019 0.0019

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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