Detailed information for compound 2077914

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 391.385 | Formula: C17H24F3N3O4
  • H donors: 1 H acceptors: 4 LogP: -0.44 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(F)(F)F.CCOC(=O)C1CN(CC2CC2)Cc2c1n(CC)cn2
  • InChi: 1S/C15H23N3O2.C2HF3O2/c1-3-18-10-16-13-9-17(7-11-5-6-11)8-12(14(13)18)15(19)20-4-2;3-2(4,5)1(6)7/h10-12H,3-9H2,1-2H3;(H,6,7)
  • InChiKey: ILWGVCFXZXEQIF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0019 0.0033
Echinococcus multilocularis snurportin 1 0.016 0.1822 0.1822
Brugia malayi RNA, U transporter 1 0.0043 0.0347 0.0614
Echinococcus multilocularis polycomb protein SCMH1 0.0025 0.0123 0.0123
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.0334 0.0334
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0448 0.0792
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.0587 0.0587
Schistosoma mansoni hypothetical protein 0.0154 0.174 0.174
Entamoeba histolytica hypothetical protein 0.0154 0.174 1
Echinococcus multilocularis phosphoglycerate kinase 1 0.0062 0.0593 0.0593
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0587 0.0587
Echinococcus multilocularis isocitrate dehydrogenase 0.0024 0.0107 0.0107
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.1393 1
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0435 0.0435
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0019 0.0019
Entamoeba histolytica hypothetical protein 0.0027 0.0147 0.0391
Echinococcus granulosus histone acetyltransferase MYST2 0.0028 0.0166 0.0166
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0021 0.0077 0.0626
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0023 0.0098 0.139
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.005 0.0441 0.7357
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0028 0.0166 0.0166
Schistosoma mansoni lamin 0.0028 0.0167 0.0167
Echinococcus granulosus phosphoglycerate kinase 1 0.0062 0.0593 0.0593
Toxoplasma gondii orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase 0.005 0.0441 0.2292
Echinococcus granulosus neuropeptide s receptor 0.0493 0.6002 0.6002
Echinococcus multilocularis neuropeptide s receptor 0.0493 0.6002 0.6002
Schistosoma mansoni hypothetical protein 0.0051 0.0448 0.0448
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0168 0.1923 0.1923
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0028 0.0469
Brugia malayi bHLH-PAS transcription factor 0.0033 0.0223 0.0394
Loa Loa (eye worm) hypothetical protein 0.0025 0.0123 0.0218
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0465 0.5652 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.0643 0.3342
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0024 0.0107 0.1304
Mycobacterium ulcerans endonuclease IV 0.008 0.0822 1
Toxoplasma gondii melibiase subfamily protein 0.0168 0.1923 1
Echinococcus granulosus GPCR family 2 0.004 0.0315 0.0315
Onchocerca volvulus 0.0028 0.0167 0.0142
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0168 0.1923 0.1923
Schistosoma mansoni hypothetical protein 0.004 0.0315 0.0315
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0168 0.1923 0.1923
Echinococcus granulosus lamin 0.0028 0.0167 0.0167
Echinococcus granulosus neuropeptide receptor A26 0.0493 0.6002 0.6002
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.0587 0.0587
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0167 0.0296
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0191 0.2208 0.3906
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0019 0.0019
Trypanosoma brucei phosphoglycerate kinase 0.0062 0.0593 1
Mycobacterium ulcerans epimerase 0.0021 0.0077 0.0626
Leishmania major trypanothione reductase 0.005 0.0435 0.7259
Loa Loa (eye worm) runx1 0.0058 0.0544 0.0963
Brugia malayi Phospholipase A2 family protein 0.0034 0.0234 0.0414
Brugia malayi jmjC domain containing protein 0.0016 0.0019 0.0033
Loa Loa (eye worm) isocitrate dehydrogenase 0.0024 0.0107 0.019
Brugia malayi Pre-SET motif family protein 0.0462 0.5607 0.9919
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0019 0.0019
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0019 0.0096
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.008 0.0822 0.1455
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0127 0.1402 0.248
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0154 0.174 0.174
Echinococcus multilocularis histone acetyltransferase MYST2 0.0028 0.0166 0.0166
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0034 0.0243 0.3904
Echinococcus granulosus dna polymerase eta 0.0023 0.0106 0.0106
Mycobacterium tuberculosis Probable reductase 0.0113 0.1234 0.2891
Plasmodium vivax glutathione reductase, putative 0.005 0.0435 0.5292
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.004 0.0315 0.0315
Echinococcus multilocularis dna polymerase eta 0.0023 0.0106 0.0106
Schistosoma mansoni orotidine 5'-phosphate decarboxylase 0.005 0.0441 0.0441
Brugia malayi Isocitrate dehydrogenase 0.0024 0.0107 0.019
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.0587 0.0587
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0028 0.0338
Brugia malayi orotate phosphoribosyltransferase family protein 0.005 0.0441 0.078
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0024 0.0107 0.1546
Echinococcus multilocularis Peptidase C54 0.0022 0.0082 0.0082
Echinococcus granulosus cysteine protease atg4b 0.0022 0.0082 0.0082
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0462 0.5607 0.9919
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0022 0.0082 0.0085
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0019 0.0019
Echinococcus granulosus polycomb protein SCMH1 0.0025 0.0123 0.0123
Echinococcus multilocularis transfer RNA-Lys 0.0033 0.0223 0.0223
Loa Loa (eye worm) mbt repeat family protein 0.0025 0.0123 0.0218
Schistosoma mansoni hypothetical protein 0.0151 0.1705 0.1705
Echinococcus multilocularis survival motor neuron protein 1 0.0248 0.293 0.293
Plasmodium falciparum glutathione reductase 0.005 0.0435 0.5292
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0154 0.174 0.174
Onchocerca volvulus 0.0033 0.0223 0.0229
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0028 0.0049
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0106 0.1783
Trypanosoma brucei phosphoglycerate kinase 0.0062 0.0593 1
Echinococcus multilocularis GA binding protein alpha chain 0.0042 0.0335 0.0335
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0077 0.0119
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0028 0.0144
Echinococcus multilocularis neuropeptide receptor A26 0.0493 0.6002 0.6002
Schistosoma mansoni autophagin-1 (C54 family) 0.0022 0.0082 0.0082
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.016 0.1822 0.3223
Loa Loa (eye worm) hypothetical protein 0.0248 0.293 0.5183
Schistosoma mansoni hypothetical protein 0.0087 0.0899 0.0899
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0168 0.2038
Echinococcus multilocularis lamin dm0 0.0028 0.0167 0.0167
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0168 0.1923 0.1923
Toxoplasma gondii thioredoxin reductase 0.005 0.0435 0.2263
Loa Loa (eye worm) hypothetical protein 0.0465 0.5652 1
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.005 0.0441 0.7357
Onchocerca volvulus 0.0465 0.5652 0.8807
Brugia malayi mbt repeat family protein 0.0025 0.0123 0.0218
Brugia malayi Peptidase family C54 containing protein 0.0022 0.0082 0.0146
Brugia malayi Phosphoglycerate kinase 0.0023 0.0098 0.0174
Schistosoma mansoni hypothetical protein 0.004 0.0315 0.0315
Brugia malayi hypothetical protein 0.0028 0.0168 0.0296
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0025 0.0123 0.0123
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0028 0.0161
Schistosoma mansoni lozenge 0.0058 0.0544 0.0544
Toxoplasma gondii isocitrate dehydrogenase 0.0024 0.0107 0.0558
Loa Loa (eye worm) hypothetical protein 0.0028 0.0167 0.0296
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.004 0.0315 0.0315
Onchocerca volvulus 0.0525 0.6407 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0019 0.0096
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0334 0.0334
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0028 0.0338
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0024 0.0107 0.181
Echinococcus multilocularis Protein lozenge 0.0058 0.0544 0.0544
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0028 0.0161 0.0284
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0168 0.1923 0.1923
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0098 0.1039 0.1039
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.1234 0.2891
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0024 0.0107 0.0107
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0167 0.0296
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0028 0.0161
Loa Loa (eye worm) MH2 domain-containing protein 0.0106 0.1139 0.2015
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0022 0.0082 0.0085
Plasmodium falciparum orotidine 5'-phosphate decarboxylase 0.005 0.0441 0.536
Loa Loa (eye worm) hypothetical protein 0.016 0.1817 0.3214
Loa Loa (eye worm) hypothetical protein 0.0087 0.0899 0.159
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.1234 0.8793
Loa Loa (eye worm) hypothetical protein 0.0023 0.0106 0.0187
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0028 0.0469
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0024 0.0107 0.1304
Brugia malayi Ets-domain containing protein 0.0042 0.0335 0.0593
Brugia malayi intermediate filament protein 0.0028 0.0167 0.0296
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0435 0.7259
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0024 0.0107 0.0107
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0435 0.077
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.0334 0.0334
Trypanosoma brucei phosphoglycerate kinase, putative 0.0023 0.0098 0.1659
Brugia malayi Calcitonin receptor-like protein seb-1 0.0127 0.1402 0.248
Giardia lamblia Phosphoglycerate kinase 0.0062 0.0593 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0064 0.0612 0.0612
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0167 0.0296
Echinococcus multilocularis cysteine protease atg4b 0.0022 0.0082 0.0082
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0028 0.0338
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.0557
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0168 0.0871
Loa Loa (eye worm) hypothetical protein 0.0021 0.0077 0.0137
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0168 0.2828
Brugia malayi latrophilin 2 splice variant baaae 0.0087 0.0899 0.159
Schistosoma mansoni hypothetical protein 0.0811 1 1
Brugia malayi hypothetical protein 0.0148 0.1674 0.2962
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0028 0.0028
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0062 0.0593 0.308
Entamoeba histolytica hypothetical protein 0.0027 0.0147 0.0391
Brugia malayi hypothetical protein 0.0465 0.5652 1
Plasmodium vivax phosphoglycerate kinase, putative 0.0062 0.0593 0.7205
Plasmodium falciparum phosphoglycerate kinase 0.0062 0.0593 0.7205
Loa Loa (eye worm) hypothetical protein 0.0034 0.0234 0.0414
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0019 0.0019
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0168 0.2597
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0062 0.0593 0.1353
Echinococcus granulosus phd:f box containing protein 0.0016 0.0019 0.0019
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0587 0.0587
Schistosoma mansoni lamin 0.0028 0.0167 0.0167
Plasmodium falciparum thioredoxin reductase 0.005 0.0435 0.5292
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0019 0.0019
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0024 0.0107 0.0107
Loa Loa (eye worm) MBCTL1 0.0028 0.0166 0.0294
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0028 0.0161
Loa Loa (eye worm) hypothetical protein 0.008 0.0822 0.1455
Loa Loa (eye worm) replication-associated protein 0.0027 0.0147 0.026
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0024 0.0107 0.0107
Schistosoma mansoni intermediate filament proteins 0.0028 0.0167 0.0167
Leishmania major phosphoglycerate kinase B, cytosolic 0.0062 0.0593 1
Schistosoma mansoni hypothetical protein 0.0085 0.0878 0.0878
Loa Loa (eye worm) hypothetical protein 0.0112 0.122 0.2158
Schistosoma mansoni phosphoglycerate kinase 0.0062 0.0593 0.0593
Toxoplasma gondii endonuclease IV APN 0.008 0.0822 0.4276
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.008 0.0822 0.1904
Toxoplasma gondii Alpha-galactosidase 0.0024 0.0111 0.0575
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0028 0.0469
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0022 0.0082 0.1388
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0028 0.0469
Chlamydia trachomatis endonuclease IV 0.008 0.0822 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0019 0.0033
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0106 0.0187
Brugia malayi glutathione reductase 0.005 0.0435 0.077
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.1393 0.3271
Schistosoma mansoni sex comb on midleg homolog 0.0025 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0066 0.0643 0.1137
Loa Loa (eye worm) replication-associated protein 0.0027 0.0147 0.026
Schistosoma mansoni gabp alpha 0.0042 0.0335 0.0335
Echinococcus granulosus SAM and MBT domain containing protein 0.0025 0.0123 0.0123
Onchocerca volvulus 0.0025 0.0123 0.0072
Onchocerca volvulus 0.0027 0.0147 0.011
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0112 0.122 0.122
Trypanosoma brucei orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.005 0.0441 0.7439
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0033
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0146 0.1645 0.2911
Echinococcus granulosus snurportin 1 0.016 0.1822 0.1822
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0028 0.0166 0.0166
Schistosoma mansoni ets-related 0.0127 0.1401 0.1401
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0024 0.0107 0.019
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0042 0.0335 0.0593
Brugia malayi hypothetical protein 0.0018 0.0041 0.0073
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0168 0.2597
Brugia malayi Ets-domain containing protein 0.0042 0.0335 0.0593
Entamoeba histolytica phosphoglycerate kinase, putative 0.0062 0.0593 0.3078
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0028 0.0161
Brugia malayi Fli-1 protein 0.0127 0.1401 0.2478
Echinococcus granulosus GA binding protein alpha chain 0.0042 0.0335 0.0335
Echinococcus multilocularis lamin 0.0028 0.0167 0.0167
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.004 0.0315 0.0315
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0435 0.5292
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.0822 1
Echinococcus granulosus single minded 2 0.0033 0.0223 0.0223
Brugia malayi jmjC domain containing protein 0.0016 0.0019 0.0033
Onchocerca volvulus 0.0066 0.0643 0.0893
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0025 0.0123 0.0072
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0034 0.0243 0.3904
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0042 0.0334 0.059
Schistosoma mansoni single-minded 0.0044 0.0367 0.0367
Treponema pallidum phosphoglycerate kinase 0.0062 0.0593 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0643 0.0643
Brugia malayi hypoxia-induced factor 1 0.0137 0.153 0.2706
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0033
Brugia malayi hypothetical protein 0.0154 0.174 0.3078
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0024 0.0107 0.1546
Plasmodium vivax JmjC domain containing protein 0.0016 0.0019 0.0225
Echinococcus granulosus intermediate filament protein 0.0028 0.0167 0.0167
Mycobacterium leprae Probable orotidine 5'-phosphate decarboxylase PyrF (OMP decarboxylase) (OMPDCase) (OMPdecase) 0.005 0.0441 0.2762
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.0643 0.0643
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.004 0.0315 0.0315
Trypanosoma brucei trypanothione reductase 0.005 0.0435 0.7345
Leishmania major orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative 0.005 0.0441 0.7357
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0028 0.0028
Leishmania major phosphoglycerate kinase C, glycosomal 0.0062 0.0593 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0334 0.0334
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0022 0.0082 0.0082
Mycobacterium ulcerans putative regulatory protein 0.0033 0.0223 0.2451
Schistosoma mansoni phosphoglycerate kinase 0.0062 0.0593 0.0593
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.1234 0.2891
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0019 0.0033
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0168 0.2038
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0028 0.0161
Echinococcus granulosus lamin dm0 0.0028 0.0167 0.0167
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0024 0.0107 0.1546
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.1393 0.3271
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0019 0.0019
Plasmodium falciparum thioredoxin reductase 0.0017 0.0028 0.0338
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0168 0.2038
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.1393 0.3271
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0028 0.0161
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0066 0.0643 0.0643
Onchocerca volvulus 0.0027 0.0147 0.011
Schistosoma mansoni transcription factor LCR-F1 0.0154 0.174 0.174
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0022 0.0082 0.1111
Onchocerca volvulus 0.0027 0.0147 0.011
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0028 0.0338
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0002 0.0004
Brugia malayi Thioredoxin reductase 0.005 0.0435 0.077
Echinococcus multilocularis GPCR, family 2 0.004 0.0315 0.0315
Trypanosoma brucei phosphoglycerate kinase 0.0023 0.0098 0.1659
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0435 0.0976
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0019 0.0312
Brugia malayi PAS domain containing protein 0.0044 0.0367 0.0649
Entamoeba histolytica hypothetical protein 0.0154 0.174 1
Plasmodium vivax SET domain protein, putative 0.0066 0.0643 0.7817
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0028 0.0161
Onchocerca volvulus Phospholipase A2 homolog 0.016 0.1817 0.2748
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.0334 0.0334
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.011 0.0195
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.008 0.0822 0.5664
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0022 0.0082 0.0085
Loa Loa (eye worm) hypothetical protein 0.0028 0.0166 0.0294
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0042 0.0334 0.059
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0024 0.0107 0.0107
Mycobacterium tuberculosis Possible exported protein 0.035 0.4201 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0019 0.0225
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0023 0.0098 0.139
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0112 0.122 0.122
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.1234 0.2891
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0066 0.0643 0.0643
Leishmania major hypothetical protein, conserved 0.0028 0.0168 0.2597
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0022 0.0082 0.0085
Onchocerca volvulus Phospholipase A2 homolog 0.0034 0.0234 0.0247
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0587 0.0587
Schistosoma mansoni survival motor neuron protein 0.0051 0.0448 0.0448
Brugia malayi jmjC domain containing protein 0.0016 0.0019 0.0033
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0587 0.0587
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0127 0.1402 0.248
Brugia malayi hypothetical protein 0.0248 0.293 0.5183
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0062 0.0593 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0002 0.0004
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0435 0.0435
Schistosoma mansoni hypothetical protein 0.0811 1 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0422 0.5107 0.5107
Entamoeba histolytica hypothetical protein 0.0027 0.0147 0.0391
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0022 0.0082 0.0085
Echinococcus multilocularis musashi 0.0028 0.0167 0.0167
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0028 0.0161
Schistosoma mansoni hypothetical protein 0.004 0.0315 0.0315
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0023 0.0098 0.139
Mycobacterium ulcerans hypothetical protein 0.0021 0.0077 0.0626
Echinococcus multilocularis SAM and MBT domain containing protein 0.0025 0.0123 0.0123
Echinococcus granulosus uridine 5' monophosphate synthase 0.005 0.0441 0.0441
Loa Loa (eye worm) latrophilin receptor protein 2 0.004 0.0315 0.0557
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0168 0.1923 0.1923
Loa Loa (eye worm) hypothetical protein 0.0036 0.0259 0.0458
Brugia malayi Latrophilin receptor protein 2 0.004 0.0315 0.0557
Schistosoma mansoni myelin transcription factor 1 myt1 0.0028 0.0166 0.0166
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0019 0.0019
Brugia malayi follicle stimulating hormone receptor 0.0146 0.1645 0.2911
Onchocerca volvulus 0.0028 0.0167 0.0142
Brugia malayi Melibiase family protein 0.0112 0.122 0.2158
Brugia malayi Cytochrome P450 family protein 0.0024 0.011 0.0195
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0033
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0019 0.0019
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0077 0.0137
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0028 0.0161
Wolbachia endosymbiont of Brugia malayi orotidine-5'-phosphate decarboxylase 0.0504 0.6141 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.004 0.0315 0.0557
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0024 0.0111 0.0111
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0024 0.0107 0.0107
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0028 0.0144
Onchocerca volvulus 0.0027 0.0147 0.011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0028 0.0161
Brugia malayi jmjC domain containing protein 0.0062 0.0587 0.1039
Trichomonas vaginalis set domain proteins, putative 0.0525 0.6407 1
Brugia malayi Phosphoglycerate kinase 0.0062 0.0593 0.1048
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0062 0.0593 0.0885
Schistosoma mansoni hypothetical protein 0.016 0.1822 0.1822
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0028 0.0166 0.0294
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0168 0.1923 0.1923
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0062 0.0593 0.3916
Loa Loa (eye worm) hypothetical protein 0.0028 0.0168 0.0296
Onchocerca volvulus 0.0454 0.5511 0.8585
Plasmodium vivax orotidine 5'-phosphate decarboxylase, putative 0.005 0.0441 0.536
Brugia malayi isocitrate dehydrogenase 0.0024 0.0107 0.019
Onchocerca volvulus 0.0027 0.0147 0.011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0028 0.0161
Schistosoma mansoni hypothetical protein 0.004 0.0315 0.0315
Loa Loa (eye worm) hypothetical protein 0.0148 0.1674 0.2962
Loa Loa (eye worm) fli-1 protein 0.0127 0.1401 0.2478
Mycobacterium ulcerans phosphoglycerate kinase 0.0062 0.0593 0.7107
Plasmodium falciparum glutathione reductase 0.0017 0.0028 0.0338
Brugia malayi mbt repeat family protein 0.0025 0.0123 0.0218
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0587 0.1039
Brugia malayi hypothetical protein 0.0073 0.0731 0.1293
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0112 0.122 0.1869
Echinococcus granulosus survival motor neuron protein 1 0.0248 0.293 0.293
Loa Loa (eye worm) orotate phosphoribosyltransferase 0.005 0.0441 0.078
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0028 0.0161
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0062 0.0593 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0082 0.0146
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0062 0.0593 0.0924
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0106 0.1518
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0028 0.0028
Echinococcus multilocularis geminin 0.0811 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0643 0.0643
Brugia malayi jmjC domain containing protein 0.0062 0.0587 0.1039
Echinococcus granulosus Peptidase C54 0.0022 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0062 0.0593 0.1048
Mycobacterium ulcerans orotidine 5'-phosphate decarboxylase 0.005 0.0441 0.5198
Loa Loa (eye worm) glutathione reductase 0.005 0.0435 0.077
Loa Loa (eye worm) hypothetical protein 0.0127 0.1402 0.248
Chlamydia trachomatis phosphoglycerate kinase 0.0062 0.0593 0.7107
Toxoplasma gondii isocitrate dehydrogenase 0.0024 0.0107 0.0558
Loa Loa (eye worm) replication-associated protein 0.0027 0.0147 0.026
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0034 0.0243 0.3904
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0024 0.0107 0.181
Echinococcus multilocularis uridine 5' monophosphate synthase 0.005 0.0441 0.0441
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0022 0.0082 0.0082
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0028 0.0161
Echinococcus granulosus histone lysine methyltransferase setb 0.0066 0.0643 0.0643
Loa Loa (eye worm) hypoxia-induced factor 1 0.0137 0.153 0.2706
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0062 0.0593 0.308
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0019 0.0019
Brugia malayi jmjC domain containing protein 0.0016 0.0019 0.0033
Loa Loa (eye worm) transcription factor SMAD2 0.0106 0.1139 0.2015
Brugia malayi MH2 domain containing protein 0.0106 0.1139 0.2015
Entamoeba histolytica hypothetical protein 0.0154 0.174 1
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.005 0.0441 0.7357
Schistosoma mansoni sex comb on midleg homolog 0.0025 0.0123 0.0123
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0019 0.0019
Leishmania major DNA polymerase eta, putative 0.0023 0.0106 0.1518
Entamoeba histolytica hypothetical protein 0.0154 0.174 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0019 0.0019
Brugia malayi Pre-SET motif family protein 0.0066 0.0643 0.1137
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0643 0.0643
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.0822 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.1234 0.2891
Onchocerca volvulus 0.0051 0.0448 0.0585
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0022 0.0082 0.1111
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0062 0.0593 0.0885
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.1234 0.2891
Schistosoma mansoni DNA polymerase eta 0.0023 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0027 0.0147 0.026
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0019 0.0019
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0098 0.1039 0.1039
Schistosoma mansoni aryl hydrocarbon receptor 0.0044 0.0367 0.0367

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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