Detailed information for compound 209924

Basic information

Technical information
  • TDR Targets ID: 209924
  • Name: 5-[2-(3,4-dichlorophenyl)ethylamino]-1-propyl -5,6,7,8-tetrahydroquinolin-2-one
  • MW: 379.323 | Formula: C20H24Cl2N2O
  • H donors: 1 H acceptors: 1 LogP: 4.21 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCn1c(=O)ccc2c1CCCC2NCCc1ccc(c(c1)Cl)Cl
  • InChi: 1S/C20H24Cl2N2O/c1-2-12-24-19-5-3-4-18(15(19)7-9-20(24)25)23-11-10-14-6-8-16(21)17(22)13-14/h6-9,13,18,23H,2-5,10-12H2,1H3
  • InChiKey: KDDRREHYUIWXQV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Acetylcholinesterase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum ko:K01049 acetylcholinesterase [EC3.1.1.7], putative Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum Acetylcholinesterase 1 precursor, putative Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) carboxylesterase Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) acetylcholinesterase 1 Get druggable targets OG5_126875 All targets in OG5_126875
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein Acetylcholinesterase   614 aa 570 aa 25.4 %
Loa Loa (eye worm) hypothetical protein Acetylcholinesterase   614 aa 574 aa 24.0 %
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Acetylcholinesterase   614 aa 602 aa 24.3 %
Brugia malayi Carboxylesterase family protein Acetylcholinesterase   614 aa 573 aa 30.5 %
Onchocerca volvulus Carnitine O-palmitoyltransferase 2, mitochondrial homolog Acetylcholinesterase   614 aa 531 aa 39.7 %
Drosophila melanogaster CG10175 gene product from transcript CG10175-RE Acetylcholinesterase   614 aa 547 aa 32.5 %
Echinococcus multilocularis neuroligin Acetylcholinesterase   614 aa 496 aa 24.0 %
Echinococcus multilocularis BC026374 protein (S09 family) Acetylcholinesterase   614 aa 642 aa 34.0 %
Echinococcus granulosus BC026374 protein S09 family Acetylcholinesterase   614 aa 642 aa 34.1 %
Onchocerca volvulus Acetylcholinesterase   614 aa 583 aa 30.7 %
Onchocerca volvulus Putative nuclear protein Acetylcholinesterase   614 aa 577 aa 40.7 %
Onchocerca volvulus Molybdopterin synthase catalytic subunit homolog Acetylcholinesterase   614 aa 564 aa 29.8 %
Onchocerca volvulus Acetylcholinesterase   614 aa 581 aa 27.0 %
Brugia malayi Carboxylesterase family protein Acetylcholinesterase   614 aa 507 aa 26.4 %
Onchocerca volvulus Acetylcholinesterase   614 aa 632 aa 25.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Sugar transporter family protein 0.0102 0.1616 0.1597
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0103 0.014
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0014 0.0049 0.0127
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0017 0.0103 0.0081
Loa Loa (eye worm) hypothetical protein 0.0027 0.0279 0.0257
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0157 0.0227
Onchocerca volvulus 0.0017 0.0103 0.0054
Echinococcus multilocularis G-protein coupled receptor, putative 0.0017 0.0103 0.014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0057 0.0035
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0017 0.0103 0.014
Brugia malayi Dopamine receptor 0.0017 0.0103 0.0081
Toxoplasma gondii sugar transporter ST3 0.0014 0.0057 0.0355
Echinococcus granulosus para nitrobenzyl esterase 0.0014 0.0049 0.0053
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0623 0.0973
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0146 0.0308
Schistosoma mansoni sugar transporter 0.0014 0.0057 0.0159
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0017 0.0103 0.0081
Schistosoma mansoni calpain (C02 family) 0.0019 0.0146 0.0501
Trypanosoma cruzi hexose transporter 0.0032 0.0365 0.1064
Schistosoma mansoni BC026374 protein (S09 family) 0.0014 0.0049 0.0127
Onchocerca volvulus 0.0017 0.0103 0.0054
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0182 0.3041 0.3007
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Brugia malayi G protein-coupled receptor F59B2.13 0.0017 0.0103 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0365 0.0332
Loa Loa (eye worm) carboxylesterase 0.0014 0.0049 0.0027
Echinococcus multilocularis dro:myosuppressin receptor 0.0017 0.0103 0.014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0057 0.0035
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Echinococcus granulosus 7TM GPCR rhodopsin 0.0017 0.0103 0.014
Trypanosoma cruzi kinesin, putative 0.0019 0.0146 0.0308
Echinococcus multilocularis g-protein coupled receptor 0.0017 0.0103 0.014
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0103 0.014
Onchocerca volvulus 0.0014 0.0057 0.0008
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0103 0.0335
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0103 0.0335
Toxoplasma gondii sugar transporter ST1 0.0014 0.0057 0.0355
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0103 0.0335
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0572 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0057 0.0024
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0103 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0365 0.0332
Echinococcus multilocularis G protein coupled receptor 139 0.0017 0.0103 0.014
Trypanosoma brucei glucose transporter, putative 0.0032 0.0365 0.1064
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0057 0.0024
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0103 0.014
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0146 0.0501
Brugia malayi Melatonin receptor type 1A 0.0017 0.0103 0.0081
Echinococcus multilocularis acetylcholinesterase 0.0082 0.1262 0.1996
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0022 0.001
Echinococcus granulosus neuroligin 0.0014 0.0049 0.0053
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Onchocerca volvulus 0.0017 0.0103 0.0054
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0012 0.0022 0.001
Brugia malayi G-protein coupled receptor 0.0017 0.0103 0.0081
Schistosoma mansoni biogenic amine receptor 0.0017 0.0103 0.0335
Brugia malayi putative neuropeptide receptor 0.0017 0.0103 0.0081
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0103 0.014
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1616 0.2564
Trypanosoma brucei glucose transporter, putative 0.0032 0.0365 0.1064
Onchocerca volvulus Putative transporter 0.0014 0.0057 0.0008
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0365 0.0332
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Echinococcus granulosus General substrate transporter 0.0087 0.1361 0.2156
Echinococcus granulosus neuropeptide receptor A26 0.0017 0.0103 0.014
Echinococcus multilocularis carboxylesterase 5A 0.0082 0.1262 0.1996
Leishmania major glucose transporter, lmgt1 0.0032 0.0365 0.1064
Brugia malayi hypothetical protein 0.0017 0.0103 0.0081
Loa Loa (eye worm) hypothetical protein 0.0014 0.0057 0.0035
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Trypanosoma cruzi hypothetical protein, conserved 0.0176 0.2946 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0014 0.0049 0.0127
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0279 0.0766
Loa Loa (eye worm) hypothetical protein 0.0014 0.0057 0.0035
Loa Loa (eye worm) hypothetical protein 0.007 0.1057 0.1038
Brugia malayi hypothetical protein 0.0027 0.0279 0.0257
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0103 0.014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0103 0.0335
Brugia malayi calpain 7 0.0019 0.0146 0.0124
Onchocerca volvulus 0.0017 0.0103 0.0054
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0146 0.0501
Brugia malayi hypothetical protein 0.0017 0.0103 0.0081
Brugia malayi RE15519p 0.0017 0.0103 0.0081
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0103 0.014
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0103 0.0335
Brugia malayi larval opioid receptor 0.0017 0.0103 0.0081
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0017 0.0103 0.0335
Onchocerca volvulus Neuropeptide F receptor homolog 0.0017 0.0103 0.0054
Schistosoma mansoni biogenic amine receptor 0.0017 0.0103 0.0335
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0103 0.0335
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Echinococcus multilocularis serotonin receptor 0.0017 0.0103 0.014
Onchocerca volvulus 0.0014 0.0057 0.0008
Onchocerca volvulus 0.0017 0.0103 0.0054
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0057 0.0066
Brugia malayi G-protein coupled receptor 0.0017 0.0103 0.0081
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0103 0.014
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.1616 0.2564
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0103 0.0335
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0103 0.014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0103 0.014
Echinococcus multilocularis calpain A 0.0068 0.1017 0.1604
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0103 0.014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Onchocerca volvulus 0.0017 0.0103 0.0054
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0365 0.1064
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Plasmodium vivax hexose transporter 0.0102 0.1616 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0623 0.2333
Trypanosoma cruzi kinesin, putative 0.0019 0.0146 0.0308
Schistosoma mansoni hypothetical protein 0.0033 0.0383 0.1412
Brugia malayi BRM protein 0.0071 0.1071 0.1051
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0014 0.0049 0.0053
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Brugia malayi hypothetical protein 0.0017 0.0103 0.0081
Plasmodium falciparum hexose transporter 0.0102 0.1616 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.1638 0.162
Schistosoma mansoni amine GPCR 0.0017 0.0103 0.0335
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0383 0.0362
Echinococcus multilocularis solute carrier family 22 0.0014 0.0057 0.0066
Brugia malayi ORL1-like opioid receptor 0.0017 0.0103 0.0081
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0279 0.1724
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Echinococcus granulosus RUN 0.002 0.0157 0.0227
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0158 0.2617 1
Loa Loa (eye worm) calpain 5 0.0019 0.0146 0.0125
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0623 0.0602
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0365 0.1064
Schistosoma mansoni neuropeptide f receptor 76f 0.0017 0.0103 0.0335
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Schistosoma mansoni amine GPCR 0.0017 0.0103 0.0335
Schistosoma mansoni amine GPCR 0.0017 0.0103 0.0335
Loa Loa (eye worm) hypothetical protein 0.0014 0.0057 0.0035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0623 0.2333
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0103 0.014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0057 0.0035
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0103 0.014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0103 0.014
Brugia malayi hypothetical protein 0.0017 0.0103 0.0081
Echinococcus granulosus sex peptide receptor 0.0017 0.0103 0.014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0057 0.0035
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0103 0.014
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0013 0.0034 0.0208
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Trypanosoma brucei kinesin, putative 0.0019 0.0146 0.0308
Schistosoma mansoni neuropeptide receptor 0.0017 0.0103 0.0335
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0019 0.0146 0.0308
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0103 0.014
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Schistosoma mansoni neuropeptide receptor 0.0017 0.0103 0.0335
Schistosoma mansoni hypothetical protein 0.0033 0.0383 0.1412
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0157 0.0975
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0103 0.014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0049 0.0027
Entamoeba histolytica hypothetical protein 0.0105 0.1671 0.1547
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0103 0.0335
Echinococcus granulosus neuropeptide receptor 0.0017 0.0103 0.014
Leishmania major hypothetical protein, conserved 0.0027 0.0279 0.0766
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0279 0.1724
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0017 0.0103 0.014
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0365 0.1064
Onchocerca volvulus 0.0014 0.0057 0.0008
Schistosoma mansoni glucose transport protein 0.0102 0.1616 0.615
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Echinococcus multilocularis BRK domain 0.0012 0.0022 0.001
Onchocerca volvulus 0.0014 0.0057 0.0008
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0065 0.0958 0.3621
Echinococcus granulosus alpha 1A adrenergic receptor 0.0017 0.0103 0.014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Loa Loa (eye worm) hypothetical protein 0.0014 0.0049 0.0027
Trypanosoma brucei antigen, putative 0.0019 0.0146 0.0308
Loa Loa (eye worm) hypothetical protein 0.0014 0.0057 0.0035
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0103 0.0081
Echinococcus multilocularis calpain family protein 1, d 0.0046 0.0614 0.0959
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0017 0.0103 0.014
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Onchocerca volvulus 0.0014 0.0057 0.0008
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0103 0.014
Echinococcus multilocularis serotonin receptor 0.0017 0.0103 0.014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0365 0.1064
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0022 0.001
Brugia malayi hypothetical protein 0.0017 0.0103 0.0081
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0017 0.0103 0.0081
Trichomonas vaginalis spcc417.12 protein, putative 0.0014 0.0049 0.0015
Echinococcus multilocularis calpain 0.0019 0.0146 0.0209
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0623 0.0973
Echinococcus multilocularis solute carrier family 22 0.0014 0.0057 0.0066
Onchocerca volvulus 0.0017 0.0103 0.0054
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0365 0.1064
Loa Loa (eye worm) hypothetical protein 0.0014 0.0049 0.0027
Schistosoma mansoni neuropeptide receptor 0.0017 0.0103 0.0335
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0146 0.0308
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Schistosoma mansoni glucose transport protein 0.0102 0.1616 0.615
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0146 0.0308
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0279 0.1724
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Echinococcus granulosus GPCR family 2 0.0033 0.0383 0.0589
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0103 0.014
Loa Loa (eye worm) calpain 0.0019 0.0146 0.0125
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0365 0.0332
Brugia malayi Sugar transporter family protein 0.0014 0.0057 0.0035
Brugia malayi N-terminal motif family protein 0.0182 0.3041 0.3025
Onchocerca volvulus 0.0014 0.0057 0.0008
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0017 0.0103 0.0081
Brugia malayi Serotonin receptor 0.0017 0.0103 0.0081
Schistosoma mansoni hypothetical protein 0.0017 0.0103 0.0335
Schistosoma mansoni myosin xvIII 0.0017 0.0103 0.0335
Brugia malayi Doublecortin family protein 0.002 0.0157 0.0136
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0157 0.0975
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Echinococcus granulosus neuropeptide receptor 0.0017 0.0103 0.014
Brugia malayi Dopamine receptor protein 1 0.0017 0.0103 0.0081
Echinococcus granulosus BRK domain containing protein 0.0012 0.0022 0.001
Echinococcus granulosus G protein coupled receptor 139 0.0017 0.0103 0.014
Brugia malayi hypothetical protein 0.0014 0.0057 0.0035
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0146 0.0308
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0157 0.0227
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0623 0.0973
Brugia malayi Carboxylesterase family protein 0.0014 0.0049 0.0027
Schistosoma mansoni hypothetical protein 0.0012 0.0022 0.0023
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0146 0.0308
Onchocerca volvulus 0.0017 0.0103 0.0054
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Loa Loa (eye worm) sugar transporter 0.0014 0.0057 0.0035
Schistosoma mansoni lipoxygenase 0.0056 0.0797 0.3001
Brugia malayi AKH receptor 0.0017 0.0103 0.0081
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0103 0.014
Trypanosoma cruzi hypothetical protein, conserved 0.0176 0.2946 1
Loa Loa (eye worm) doublecortin family protein 0.002 0.0157 0.0136
Onchocerca volvulus 0.002 0.0157 0.0109
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0103 0.0335
Brugia malayi sulfakinin receptor protein 0.0017 0.0103 0.0081
Trypanosoma brucei glucose transporter 2A 0.0032 0.0365 0.1064
Echinococcus granulosus acetylcholinesterase 0.0082 0.1262 0.1996
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Schistosoma mansoni biogenic amine receptor 0.0017 0.0103 0.0335
Onchocerca volvulus 0.0017 0.0103 0.0054
Brugia malayi Dopamine receptor protein 2 0.0017 0.0103 0.0081
Echinococcus granulosus neuropeptide FF receptor 2 0.0017 0.0103 0.014
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0017 0.0103 0.0081
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0057 0.0035
Brugia malayi hypothetical protein 0.0014 0.0057 0.0035
Schistosoma mansoni polycystin 1-related 0.002 0.0157 0.0544
Onchocerca volvulus 0.0014 0.0057 0.0008
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0157 0.0227
Loa Loa (eye worm) hypothetical protein 0.0082 0.1262 0.1242
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0017 0.0103 0.0335
Brugia malayi Carboxylesterase family protein 0.0014 0.0049 0.0027
Trypanosoma brucei glucose transporter, putative 0.0032 0.0365 0.1064
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0623 0.0602
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0103 0.014
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0103 0.014
Leishmania major glucose transporter, lmgt3 0.0032 0.0365 0.1064
Mycobacterium ulcerans sugar transporter 0.0014 0.0057 0.0008
Schistosoma mansoni opsin-like receptor 0.0017 0.0103 0.0335
Echinococcus multilocularis calpain 7 (C02 family) 0.0019 0.0146 0.0209
Echinococcus multilocularis General substrate transporter 0.0087 0.1361 0.2156
Schistosoma mansoni hypothetical protein 0.0085 0.1318 0.5006
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0383 0.0589
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0057 0.0008
Schistosoma mansoni hypothetical protein 0.002 0.0157 0.0544
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Loa Loa (eye worm) hypothetical protein 0.0014 0.0049 0.0027
Loa Loa (eye worm) hypothetical protein 0.0014 0.0057 0.0035
Onchocerca volvulus 0.0014 0.0057 0.0008
Brugia malayi hypothetical protein 0.0014 0.0057 0.0035
Loa Loa (eye worm) calpain family protein 1 0.0065 0.0958 0.0938
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0146 0.0308
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0017 0.0103 0.0335
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0103 0.014
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0572 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Echinococcus multilocularis para nitrobenzyl esterase 0.0014 0.0049 0.0053
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0146 0.0308
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0146 0.0308
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0082 0.1262 0.4788
Loa Loa (eye worm) TYRA-2 protein 0.0017 0.0103 0.0081
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0057 0.0355
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0017 0.0103 0.0335
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0017 0.0103 0.0081
Brugia malayi hypothetical protein 0.0017 0.0103 0.0081
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0103 0.0335
Brugia malayi hypothetical protein 0.0017 0.011 0.0088
Echinococcus granulosus calpain 0.0019 0.0146 0.0209
Loa Loa (eye worm) hypothetical protein 0.0046 0.0614 0.0593
Brugia malayi neuropeptide F receptor 0.0017 0.0103 0.0081
Echinococcus granulosus peptide allatostatin:somatostatin 0.0017 0.0103 0.014
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0572 1 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0017 0.0103 0.014
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0017 0.0103 0.0335
Echinococcus granulosus acetylcholinesterase 0.0082 0.1262 0.1996
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Schistosoma mansoni sugar transporter 0.0014 0.0057 0.0159
Onchocerca volvulus 0.0014 0.0057 0.0008
Trypanosoma brucei glucose transporter, putative 0.0032 0.0365 0.1064
Brugia malayi Carboxylesterase family protein 0.0082 0.1262 0.1242
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0103 0.014
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0057 0.0159
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.1638 0.162
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0572 1 1
Echinococcus granulosus calpain A 0.0019 0.0146 0.0209
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0146 0.0308
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0103 0.0081
Loa Loa (eye worm) melatonin receptor type 1A 0.0017 0.0103 0.0081
Schistosoma mansoni hypothetical protein 0.0102 0.1616 0.615
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.1616 0.2564
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0103 0.014
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0103 0.0335
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0014 0.0049 0.0127
Loa Loa (eye worm) hypothetical protein 0.0065 0.0958 0.0938
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0103 0.014
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0146 0.0308
Echinococcus multilocularis sex peptide receptor 0.0017 0.0103 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0057 0.0024
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0014 0.0057 0.0012
Brugia malayi hypothetical protein 0.0017 0.0103 0.0081
Brugia malayi neuropeptide F receptor 0.0017 0.0103 0.0081
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.0797 0.1251
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0103 0.0335
Echinococcus multilocularis BC026374 protein (S09 family) 0.0014 0.0049 0.0053
Brugia malayi hypothetical protein 0.0014 0.0049 0.0027
Schistosoma mansoni amine GPCR 0.0017 0.0103 0.0335
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0057 0.0024
Brugia malayi putative neuropeptide receptor NPR1 0.0017 0.0103 0.0081
Schistosoma mansoni sugar transporter 0.0014 0.0057 0.0159
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0017 0.0103 0.014
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0103 0.014
Echinococcus granulosus carboxylesterase 5A 0.0082 0.1262 0.1996
Loa Loa (eye worm) BRM protein 0.0045 0.0613 0.0592
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0176 0.2946 0.2922
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0103 0.0081
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Schistosoma mansoni rab6-interacting 0.002 0.0157 0.0544
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0176 0.2946 1
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0103 0.014
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0103 0.014
Loa Loa (eye worm) hypothetical protein 0.0082 0.1262 0.1242
Onchocerca volvulus 0.0014 0.0057 0.0008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0623 0.0973
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0017 0.0103 0.0081
Echinococcus multilocularis acetylcholinesterase 0.0082 0.1262 0.1996
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0103 0.0081
Echinococcus multilocularis GPCR, family 2 0.0033 0.0383 0.0589
Brugia malayi hypothetical protein 0.0017 0.0103 0.0081
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0103 0.0335
Schistosoma mansoni gliotactin 0.0014 0.0049 0.0127
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0057 0.0035
Schistosoma mansoni hypothetical protein 0.0012 0.0022 0.0024
Schistosoma mansoni opsin-like receptor 0.0017 0.0103 0.0335
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.1638 0.162
Plasmodium vivax sugar transporter, putative 0.0014 0.0057 0.0355
Schistosoma mansoni neuropeptide receptor 0.0017 0.0103 0.0335
Loa Loa (eye worm) carboxylesterase 0.0014 0.0049 0.0027
Onchocerca volvulus 0.0572 1 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0146 0.0308
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0572 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0103 0.014
Echinococcus granulosus allatostatin A receptor 0.0017 0.0103 0.014
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0365 0.0332
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0017 0.0103 0.0081
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0103 0.0335
Brugia malayi calpain family protein 1 0.0065 0.0958 0.0938
Schistosoma mansoni calpain C (C02 family) 0.0019 0.0146 0.0501
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0279 0.1724
Echinococcus granulosus neuropeptide s receptor 0.0017 0.0103 0.014
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0103 0.014
Echinococcus granulosus calpain 5 0.0019 0.0146 0.0209
Echinococcus multilocularis neuropeptide receptor A26 0.0017 0.0103 0.014
Trypanosoma brucei glucose transporter, putative 0.0032 0.0365 0.1064
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0146 0.0308
Schistosoma mansoni acetylcholinesterase 0.0014 0.0049 0.0127
Loa Loa (eye worm) hypothetical protein 0.0014 0.0057 0.0035
Echinococcus granulosus dro:myosuppressin receptor 0.0017 0.0103 0.014
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0057 0.0035
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0103 0.0335
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0057 0.0024
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0105 0.1671 0.1547
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1616 0.2564
Schistosoma mansoni amine GPCR 0.0017 0.0103 0.0335
Trypanosoma brucei glucose transporter, putative 0.0032 0.0365 0.1064
Loa Loa (eye worm) hypothetical protein 0.0014 0.0049 0.0027
Loa Loa (eye worm) hypothetical protein 0.0014 0.0057 0.0035
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0057 0.0066
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0017 0.0103 0.0335
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0014 0.0057 0.0012
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.008 0.1221 0.4634
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0165 0.2737 0.4362
Loa Loa (eye worm) hypothetical protein 0.0014 0.0057 0.0035
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0103 0.014
Schistosoma mansoni neuroligin 3 (S09 family) 0.0014 0.0049 0.0127
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0057 0.5
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0146 0.0308
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0014 0.0049 0.0053
Echinococcus granulosus voltage dependent calcium channel subunit 0.0362 0.6255 1
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0022 0.001
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Loa Loa (eye worm) calpain family protein 1 0.0046 0.0614 0.0593
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0057 0.0008
Loa Loa (eye worm) hypothetical protein 0.002 0.0157 0.0136
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0068 0.1017 0.3848
Schistosoma mansoni hypothetical protein 0.0033 0.0383 0.1412
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0365 0.1064
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Echinococcus granulosus solute carrier family 22 0.0014 0.0057 0.0066
Onchocerca volvulus 0.0014 0.0057 0.0008
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Echinococcus granulosus solute carrier family 22 0.0014 0.0057 0.0066
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Onchocerca volvulus 0.002 0.0157 0.0109
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0279 0.0766
Echinococcus multilocularis allatostatin A receptor 0.0017 0.0103 0.014
Brugia malayi hypothetical protein 0.002 0.0157 0.0136
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0068 0.1017 0.1604
Trypanosoma brucei glucose transporter, putative 0.0032 0.0365 0.1064
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0017 0.0103 0.0335
Schistosoma mansoni lipoxygenase 0.002 0.0157 0.0544
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0383 0.0362
Onchocerca volvulus 0.0017 0.0103 0.0054
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0103 0.014
Schistosoma mansoni hypothetical protein 0.0033 0.0383 0.1412
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0103 0.014
Brugia malayi calpain 5 0.0019 0.0146 0.0124
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0017 0.0103 0.014
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.1616 1
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0068 0.1017 0.1604
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0068 0.1017 0.3848
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0176 0.2946 0.2922
Echinococcus multilocularis global transcription activator snf2l2 0.0071 0.1071 0.1691
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0103 0.014
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0017 0.0103 0.014
Echinococcus granulosus global transcription activator snf2l2 0.0071 0.1071 0.1691
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0572 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0017 0.0103 0.014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Echinococcus multilocularis solute carrier family 22 0.0014 0.0057 0.0066
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0103 0.014
Onchocerca volvulus 0.0014 0.0057 0.0008
Schistosoma mansoni loxhd1 0.002 0.0157 0.0544
Echinococcus granulosus g-protein coupled receptor 0.0017 0.0103 0.014
Schistosoma mansoni hypothetical protein 0.0017 0.0103 0.0335
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0103 0.014
Brugia malayi major facilitator superfamily protein 0.0014 0.0057 0.0035
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0279 0.0766
Schistosoma mansoni serine-rich repeat protein 0.0085 0.1318 0.5006
Trypanosoma brucei glucose transporter 1E 0.0032 0.0365 0.1064
Loa Loa (eye worm) acetylcholinesterase 1 0.0082 0.1262 0.1242
Brugia malayi follicle stimulating hormone receptor 0.0017 0.0103 0.0081
Loa Loa (eye worm) hypothetical protein 0.002 0.0157 0.0136
Onchocerca volvulus 0.0014 0.0057 0.0008
Echinococcus granulosus solute carrier family 22 0.0014 0.0057 0.0066
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0365 0.1064
Echinococcus multilocularis Chromo domain 0.0012 0.0022 0.001
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0396 0.6856 1
Onchocerca volvulus 0.0014 0.0057 0.0008
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Brugia malayi Sugar transporter family protein 0.0014 0.0057 0.0035
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0103 0.014
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0057 0.0355
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0103 0.0335
Schistosoma mansoni hypothetical protein 0.007 0.1057 0.4003
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0572 1 1
Onchocerca volvulus 0.0017 0.0103 0.0054
Schistosoma mansoni histamine h1 receptor 0.0017 0.0103 0.0335
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Echinococcus granulosus orexin receptor type 2 0.0017 0.0103 0.014
Onchocerca volvulus 0.0017 0.0103 0.0054
Echinococcus granulosus Chromo domain 0.0012 0.0022 0.001
Schistosoma mansoni hypothetical protein 0.0017 0.0103 0.0335
Echinococcus granulosus voltage dependent calcium channel subunit 0.0165 0.2737 0.4362
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0057 0.0066
Loa Loa (eye worm) hypothetical protein 0.0014 0.0049 0.0027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0103 0.014
Onchocerca volvulus 0.0014 0.0057 0.0008
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0572 1 1
Echinococcus multilocularis calpain 5 0.0019 0.0146 0.0209
Onchocerca volvulus 0.0017 0.0103 0.0054
Echinococcus granulosus BC026374 protein S09 family 0.0014 0.0049 0.0053
Onchocerca volvulus 0.0017 0.0103 0.0054
Onchocerca volvulus 0.0017 0.0103 0.0054
Schistosoma mansoni sugar transporter 0.0014 0.0057 0.0159
Echinococcus granulosus calpain 7 C02 family 0.0019 0.0146 0.0209
Trypanosoma cruzi hexose transporter, putative 0.0017 0.011 0.0182
Leishmania major glucose transporter, lmgt2 0.0032 0.0365 0.1064
Loa Loa (eye worm) hypothetical protein 0.0014 0.0057 0.0035
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0019 0.0146 0.0308
Echinococcus granulosus tachykinin peptides receptor 99D 0.0017 0.0103 0.014
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0365 0.0332
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0017 0.0103 0.014
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0146 0.0308
Echinococcus multilocularis somatostatin receptor 0.0017 0.0103 0.014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0383 0.0589
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0014 0.0049 0.0015
Echinococcus granulosus g protein coupled receptor 0.0017 0.0103 0.014
Leishmania major hypothetical protein, conserved 0.0176 0.2946 1
Schistosoma mansoni glucose transport protein 0.0102 0.1616 0.615
Echinococcus granulosus g protein coupled receptor 0.0017 0.0103 0.014
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0057 0.0066
Brugia malayi GnHR receptor homolog 0.0017 0.0103 0.0081
Loa Loa (eye worm) hypothetical protein 0.0014 0.0057 0.0035
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0572 1 1
Echinococcus granulosus somatostatin receptor 0.0017 0.0103 0.014
Schistosoma mansoni helicase 0.0071 0.1071 0.4056
Brugia malayi hypothetical protein 0.002 0.0157 0.0136
Schistosoma mansoni alpha-1 adrenergic receptor 0.0017 0.0103 0.0335
Onchocerca volvulus 0.0046 0.0614 0.0568
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1616 0.2564
Trypanosoma brucei glucose transporter, putative 0.0032 0.0365 0.1064
Echinococcus granulosus serotonin receptor 0.0017 0.0103 0.014
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0103 0.014
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0383 0.0589
Echinococcus granulosus solute carrier family 22 0.0014 0.0057 0.0066
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.1616 0.2564
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Schistosoma mansoni Mername-AA248 (C02 family) 0.0019 0.0146 0.0501
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Brugia malayi Carboxylesterase family protein 0.0014 0.0049 0.0027
Echinococcus multilocularis RUN 0.002 0.0157 0.0227
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.1057 0.1038
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0157 0.0227
Echinococcus granulosus hypothetical protein 0.0017 0.0103 0.014
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.0797 0.1251
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0022 0.001
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0362 0.6255 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0572 1 1
Echinococcus granulosus calpain A 0.0068 0.1017 0.1604
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0365 0.0332
Loa Loa (eye worm) carboxylesterase 0.0082 0.1262 0.1242
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0017 0.0103 0.0054
Leishmania major kinesin, putative 0.0019 0.0146 0.0308
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.1616 0.2564
Brugia malayi Cache domain containing protein 0.0073 0.1102 0.1082
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0383 0.0362
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0157 0.0227
Echinococcus multilocularis solute carrier family 22 0.0014 0.0057 0.0066
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0157 0.0227
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Echinococcus granulosus 7tm_1 domain containing protein 0.0017 0.0103 0.014
Brugia malayi hypothetical protein 0.0017 0.0103 0.0081
Echinococcus multilocularis neuropeptide s receptor 0.0017 0.0103 0.014
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0103 0.0335
Echinococcus multilocularis orexin receptor type 2 0.0017 0.0103 0.014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0057 0.0035
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0017 0.0103 0.014
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Loa Loa (eye worm) hypothetical protein 0.0046 0.0614 0.0593
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0383 0.0589
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1616 0.2564
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0368 0.637 0.6316
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0017 0.0103 0.014
Brugia malayi major facilitator superfamily protein 0.0014 0.0057 0.0035
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Brugia malayi hypothetical protein 0.0017 0.0103 0.0081
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0623 0.2333
Loa Loa (eye worm) hypothetical protein 0.0182 0.3041 0.3025
Schistosoma mansoni rab6-interacting 0.002 0.0157 0.0544
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0146 0.0308
Onchocerca volvulus 0.0017 0.0103 0.0054
Giardia lamblia DNA repair protein RAD52 0.0368 0.637 0.6349
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0146 0.0308
Schistosoma mansoni growth hormone secretagogue receptor 0.0017 0.0103 0.0335
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0057 0.0035
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0103 0.0335
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0022 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.1616 0.1588
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0017 0.0103 0.0335
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0022 0.001
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0572 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.1102 0.1082
Schistosoma mansoni glucose transporter 0.0014 0.0057 0.0159
Schistosoma mansoni opsin-like receptor 0.0017 0.0103 0.0335
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0103 0.014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Onchocerca volvulus 0.0017 0.0103 0.0054
Brugia malayi Carboxylesterase family protein 0.0082 0.1262 0.1242
Brugia malayi G protein-coupled receptor 0.0017 0.0103 0.0081
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0057 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Brugia malayi Carboxylesterase family protein 0.0014 0.0049 0.0027
Brugia malayi Serotonin receptor 0.0017 0.0103 0.0081
Echinococcus granulosus fmrfamide receptor 0.0017 0.0103 0.014
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.1638 0.162
Schistosoma mansoni hypothetical protein 0.0017 0.0103 0.0335
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0103 0.014
Loa Loa (eye worm) sugar transporter 0.0102 0.1616 0.1597
Loa Loa (eye worm) hypothetical protein 0.0014 0.0049 0.0027
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0057 0.0008
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0146 0.0308
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0017 0.0103 0.014
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0017 0.0103 0.0081
Loa Loa (eye worm) hypothetical protein 0.0033 0.0383 0.0362
Loa Loa (eye worm) hypothetical protein 0.0065 0.0958 0.0938
Brugia malayi calpain family protein 1 0.0065 0.0958 0.0938
Loa Loa (eye worm) BRM protein 0.0037 0.0458 0.0438
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0017 0.0103 0.0081
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0103 0.014
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0103 0.014
Schistosoma mansoni adenoreceptor 0.0017 0.0103 0.0335
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0057 0.0024
Echinococcus granulosus g protein coupled receptor 0.0017 0.0103 0.014
Brugia malayi Tachykinin-like peptides receptor 99D 0.0017 0.0103 0.0081
Echinococcus multilocularis hypothetical protein 0.0019 0.0146 0.0209
Echinococcus multilocularis neuroligin 0.0014 0.0049 0.0053
Onchocerca volvulus 0.0014 0.0057 0.0008
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0081
Plasmodium vivax calpain, putative 0.0019 0.0146 0.0905
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Toxoplasma gondii sugar transporter ST2 0.0014 0.0057 0.0355
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0057 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0057 0.0035
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0057 0.0024

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.05 uM Acetylcholinesterase inhibitory activity in rat striatal homogenates ChEMBL. 7658452
IC50 (binding) = 1.05 uM Acetylcholinesterase inhibitory activity in rat striatal homogenates ChEMBL. 7658452
IC50 (binding) > 100 uM The compound was tested for Butyrylcholinesterase inhibitory activity in rat striatal homogenates ChEMBL. 7658452
IC50 (binding) > 100 uM The compound was tested for Butyrylcholinesterase inhibitory activity in rat striatal homogenates ChEMBL. 7658452

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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