Detailed information for compound 21115

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 349.812 | Formula: C17H20ClN3O3
  • H donors: 3 H acceptors: 2 LogP: 4.35 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1[nH]c(cc1NC(=O)Nc1ccccc1Cl)C(C)(C)C
  • InChi: 1S/C17H20ClN3O3/c1-17(2,3)13-9-12(14(21-13)15(22)24-4)20-16(23)19-11-8-6-5-7-10(11)18/h5-9,21H,1-4H3,(H2,19,20,23)
  • InChiKey: ZYAGTYJEVFJBND-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 14 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma japonicum ko:K04441 p38 MAP kinase, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania mexicana mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Brugia malayi P38 map kinase family protein 2 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma congolense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania braziliensis mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania donovani mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania infantum mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 14 360 aa 336 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.017 0.0276
Trypanosoma brucei heat shock protein, putative 0.0026 0.0214 0.0116
Loa Loa (eye worm) doublecortin family protein 0.0019 0.013 0.013
Schistosoma mansoni neuropeptide receptor 0.0022 0.017 0.0276
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0026 0.0214 0.0994
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0026 0.0214 1
Leishmania major heat shock protein 83-1 0.0026 0.0214 0.0116
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0022 0.017 0.017
Brugia malayi putative neuropeptide receptor 0.0022 0.017 0.017
Echinococcus multilocularis serotonin receptor 0.0378 0.5043 0.8187
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.046 0.616 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0022 0.017 0.0276
Mycobacterium tuberculosis Possible two component sensor kinase 0.0026 0.0214 1
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.017 0.017
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0026 0.0214 0.4919
Schistosoma mansoni neuropeptide receptor 0.0022 0.017 0.0276
Leishmania major heat shock protein 83-1 0.0026 0.0214 0.0116
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2152 0.6177
Echinococcus granulosus neuropeptide receptor 0.0022 0.017 0.0276
Mycobacterium leprae Probable two component sensor kinase MprB 0.0026 0.0214 1
Brugia malayi neuropeptide F receptor 0.0022 0.017 0.017
Brugia malayi G-protein coupled receptor 0.0022 0.017 0.017
Leishmania major heat shock protein 83-1 0.0026 0.0214 0.0116
Echinococcus granulosus dnaJ subfamily B 0.0403 0.5387 0.8745
Loa Loa (eye worm) hypothetical protein 0.0378 0.5043 0.5043
Trypanosoma brucei Heat shock protein 83, putative 0.0026 0.0214 0.0116
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0214 0.0116
Echinococcus granulosus mitogen activated protein kinase 14 0.0152 0.1946 0.3159
Brugia malayi hypothetical protein 0.0035 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0017 0.0098 0.0098
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.046 0.616 1
Brugia malayi cytochrome P450 0.0017 0.0099 0.0099
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0022 0.017 0.0276
Mycobacterium tuberculosis Probable two component sensor kinase 0.0026 0.0214 1
Trypanosoma brucei heat shock protein 90, putative 0.0026 0.0214 0.0116
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0026 0.0214 0.0214
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.3351 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Plasmodium vivax endoplasmin, putative 0.0026 0.0214 1
Trypanosoma brucei heat shock protein, putative 0.0026 0.0214 0.0116
Leishmania major heat shock protein 83-1 0.0026 0.0214 0.0116
Brugia malayi hypothetical protein 0.0022 0.017 0.017
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0022 0.017 0.0276
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.017 0.0276
Echinococcus multilocularis g protein coupled receptor 0.0022 0.017 0.0276
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0026 0.0214 0.0116
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0026 0.0214 0.0116
Schistosoma mansoni growth hormone secretagogue receptor 0.0022 0.017 0.0276
Onchocerca volvulus 0.0019 0.013 0.0603
Echinococcus granulosus g-protein coupled receptor 0.0022 0.017 0.0276
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.017 0.0276
Schistosoma mansoni endoplasmin 0.0026 0.0214 0.0347
Echinococcus multilocularis mitogen activated protein kinase 11 0.0152 0.1946 0.3159
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0022 0.017 0.0276
Leishmania major heat shock protein 83-1 0.0026 0.0214 0.0116
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0026 0.0214 0.4919
Brugia malayi hypothetical protein 0.0022 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.017 0.0276
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0022 0.017 0.017
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2152 0.6177
Brugia malayi Cytochrome P450 family protein 0.0017 0.0099 0.0099
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0022 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Brugia malayi CXXC zinc finger family protein 0.0028 0.0251 0.0251
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.013 0.0211
Loa Loa (eye worm) hypothetical protein 0.0049 0.0531 0.0531
Echinococcus granulosus fmrfamide receptor 0.0022 0.017 0.0276
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.017 0.0276
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.017 0.0276
Echinococcus granulosus neuropeptide receptor A26 0.0022 0.017 0.0276
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0022 0.017 0.017
Echinococcus multilocularis G protein coupled receptor 139 0.0022 0.017 0.0276
Brugia malayi Endoplasmin precursor 0.0026 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0161 0.2065 0.1986
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0214 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0022 0.017 0.0276
Loa Loa (eye worm) hypothetical protein 0.0026 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Echinococcus multilocularis mitogen activated protein kinase 14 0.0152 0.1946 0.3159
Loa Loa (eye worm) hypothetical protein 0.074 1 1
Schistosoma mansoni pyruvate dehydrogenase 0.046 0.616 1
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0026 0.0214 0.0116
Schistosoma mansoni amine GPCR 0.0022 0.017 0.0276
Echinococcus granulosus glutamate receptor 2 0.0011 0.0012 0.002
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0022 0.017 0.0276
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0026 0.0214 1
Loa Loa (eye worm) TYRA-2 protein 0.0022 0.017 0.017
Echinococcus granulosus alpha 1A adrenergic receptor 0.0022 0.017 0.0276
Echinococcus granulosus 7TM GPCR rhodopsin 0.0022 0.017 0.0276
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.2152 1
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.3351 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0603 0.0603
Leishmania major heat shock protein 83-1 0.0026 0.0214 0.0116
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0026 0.0214 0.0497
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0022 0.017 0.0276
Schistosoma mansoni pyruvate dehydrogenase 0.0434 0.581 0.9431
Schistosoma mansoni hypothetical protein 0.0017 0.0099 0.016
Brugia malayi RE15519p 0.0022 0.017 0.017
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.017 0.0276
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0186 0.2415 1
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0011 0.0012 0.002
Loa Loa (eye worm) heat shock protein 90 0.0026 0.0214 0.0214
Echinococcus granulosus heat shock protein 0.0026 0.0214 0.0347
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.017 0.0276
Loa Loa (eye worm) TOPoisomerase family member 0.0026 0.0214 0.0214
Trypanosoma cruzi C-8 sterol isomerase, putative 0.074 1 1
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0026 0.0214 1
Echinococcus multilocularis heat shock protein 0.0026 0.0214 0.0347
Loa Loa (eye worm) endoplasmin 0.0026 0.0214 0.0214
Leishmania major cytochrome p450-like protein 0.0034 0.0333 0.0237
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.017 0.017
Schistosoma mansoni glutamate receptor NMDA 0.0011 0.0012 0.002
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0026 0.0214 0.0994
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.017 0.0276
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.017 0.0276
Schistosoma mansoni heat shock protein 0.0026 0.0214 0.0347
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0022 0.017 0.0276
Onchocerca volvulus 0.0022 0.017 0.0791
Trypanosoma brucei heat shock protein, putative 0.0026 0.0214 0.0116
Echinococcus granulosus biogenic amine 5HT receptor 0.0378 0.5043 0.8187
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0022 0.017 0.0276
Echinococcus multilocularis g protein coupled receptor 0.0022 0.017 0.0276
Plasmodium vivax DNA gyrase subunit B, putative 0.0026 0.0214 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.017 0.0276
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.017 0.0276
Echinococcus multilocularis neuropeptide receptor A26 0.0022 0.017 0.0276
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Brugia malayi hypothetical protein 0.0022 0.017 0.017
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0339 0.0551
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.017 0.0276
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.013 0.0211
Echinococcus multilocularis neuropeptide FF receptor 2 0.0022 0.017 0.0276
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0022 0.017 0.0276
Brugia malayi hypothetical protein 0.0022 0.017 0.017
Mycobacterium ulcerans two component sensor kinase MprB 0.0026 0.0214 0.4919
Schistosoma mansoni hypothetical protein 0.0022 0.017 0.0276
Brugia malayi GnHR receptor homolog 0.0022 0.017 0.017
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0152 0.1946 0.1866
Schistosoma mansoni hypothetical protein 0.0019 0.013 0.0211
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.0099 0.016
Schistosoma mansoni neuropeptide f receptor 76f 0.0022 0.017 0.0276
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0333 0.0333
Schistosoma mansoni neuropeptide receptor 0.0022 0.017 0.0276
Onchocerca volvulus 0.0022 0.017 0.0791
Loa Loa (eye worm) CYP4Cod1 0.0034 0.0333 0.0333
Chlamydia trachomatis DNA gyrase subunit B 0.0026 0.0214 1
Plasmodium vivax DNA topoisomerase II, putative 0.0026 0.0214 1
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0531 0.0863
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0012 0.002
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0026 0.0214 1
Onchocerca volvulus 0.0022 0.017 0.0791
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0026 0.0214 0.0347
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.3351 1
Echinococcus multilocularis mitogen activated protein kinase 11 0.0152 0.1946 0.3159
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0214 0.0116
Echinococcus multilocularis g protein coupled receptor 0.0022 0.017 0.0276
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Schistosoma mansoni amine GPCR 0.0022 0.017 0.0276
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0022 0.017 0.0276
Brugia malayi Tachykinin-like peptides receptor 99D 0.0022 0.017 0.017
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.017 0.0276
Onchocerca volvulus 0.0022 0.017 0.0791
Echinococcus granulosus g protein coupled receptor 0.0022 0.017 0.0276
Entamoeba histolytica hypothetical protein 0.0035 0.0339 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Onchocerca volvulus 0.0022 0.017 0.0791
Trypanosoma brucei heat shock protein, putative 0.0026 0.0214 0.0116
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.017 0.0276
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.017 0.0276
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0026 0.0214 1
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.3351 1
Trypanosoma brucei heat shock protein, putative 0.0026 0.0214 0.0116
Onchocerca volvulus 0.0022 0.017 0.0791
Onchocerca volvulus 0.0022 0.017 0.0791
Echinococcus multilocularis fmrfamide receptor 0.0022 0.017 0.0276
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.017 0.0276
Echinococcus multilocularis allatostatin A receptor 0.0022 0.017 0.0276
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Schistosoma mansoni adenoreceptor 0.0022 0.017 0.0276
Leishmania major mitochondrial DNA topoisomerase II 0.0026 0.0214 0.0116
Echinococcus multilocularis serotonin receptor 0.0378 0.5043 0.8187
Schistosoma mansoni cpg binding protein 0.0028 0.0251 0.0408
Schistosoma mansoni hypothetical protein 0.0022 0.017 0.0276
Schistosoma mansoni myosin xvIII 0.0022 0.017 0.0276
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0598 0.2157
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Brugia malayi sulfakinin receptor protein 0.0022 0.017 0.017
Echinococcus granulosus g protein coupled receptor 0.0022 0.017 0.0276
Echinococcus granulosus hypothetical protein 0.0022 0.017 0.0276
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0026 0.0214 1
Echinococcus granulosus dro:myosuppressin receptor 0.0022 0.017 0.0276
Trypanosoma brucei heat shock protein, putative 0.0026 0.0214 0.0116
Onchocerca volvulus 0.0022 0.017 0.0791
Echinococcus granulosus 7tm_1 domain containing protein 0.0022 0.017 0.0276
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0116 0.1456 0.2364
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2152 0.6177
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0012 0.002
Brugia malayi hypothetical protein 0.0022 0.017 0.017
Loa Loa (eye worm) cytochrome P450 0.0017 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Echinococcus multilocularis fmrfamide receptor 0.0022 0.017 0.0276
Schistosoma mansoni amine GPCR 0.0022 0.017 0.0276
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Schistosoma mansoni hypothetical protein 0.0403 0.5387 0.8745
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.017 0.0276
Schistosoma mansoni cytochrome P450 0.0017 0.0099 0.016
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.017 0.0276
Brugia malayi hypothetical protein 0.0022 0.017 0.017
Leishmania major heat shock protein 83-1 0.0026 0.0214 0.0116
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.013 0.0211
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0152 0.1946 0.1946
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0022 0.017 0.017
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0152 0.1946 0.1866
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.017 0.0276
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Echinococcus granulosus tumor protein p63 0.0333 0.4426 0.7186
Brugia malayi hypothetical protein 0.0022 0.017 0.017
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0012 0.002
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0018 0.0115 0.1457
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0249 0.3276 0.3276
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0255 0.3351 0.3351
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0214 1
Toxoplasma gondii heat shock protein HSP90 0.0026 0.0214 0.0497
Echinococcus granulosus cpg binding protein 0.003 0.0273 0.0444
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0026 0.0214 0.4919
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0026 0.0214 1
Leishmania major heat shock protein 83-1 0.0026 0.0214 0.0116
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0026 0.0214 0.4919
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0339 0.0551
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0116 0.1456 0.2364
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.017 0.0276
Echinococcus multilocularis 0.0017 0.0099 0.016
Onchocerca volvulus 0.0022 0.017 0.0791
Leishmania major heat shock protein 83-1 0.0026 0.0214 0.0116
Loa Loa (eye worm) hypothetical protein 0.0378 0.5043 0.5043
Brugia malayi Cytochrome P450 family protein 0.0034 0.0333 0.0333
Brugia malayi Cytochrome P450 family protein 0.0034 0.0333 0.0333
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0022 0.017 0.0276
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.017 0.0276
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.017 0.0276
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0026 0.0214 1
Chlamydia trachomatis DNA gyrase subunit B 0.0026 0.0214 1
Leishmania major hypothetical protein, conserved 0.0026 0.0214 0.0116
Plasmodium falciparum endoplasmin, putative 0.0026 0.0214 1
Schistosoma mansoni biogenic amine receptor 0.0022 0.017 0.0276
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0022 0.017 0.0276
Echinococcus granulosus somatostatin receptor 0.0022 0.017 0.0276
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.017 0.0276
Brugia malayi putative neuropeptide receptor NPR1 0.0022 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0026 0.0214 1
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0018 0.0115 0.0716
Entamoeba histolytica hypothetical protein 0.0035 0.0339 1
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0026 0.0214 0.5
Brugia malayi Dopamine receptor 0.0022 0.017 0.017
Brugia malayi kinase, mitochondrial precursor 0.046 0.616 0.616
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.017 0.0276
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.017 0.0276
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0026 0.0214 1
Schistosoma mansoni neuropeptide receptor 0.0022 0.017 0.0276
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0022 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.013
Entamoeba histolytica hypothetical protein 0.0035 0.0339 1
Trypanosoma brucei heat shock protein 90, putative 0.0026 0.0214 0.0116
Leishmania major heat shock protein 83-1 0.0026 0.0214 0.0116
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.017 0.0276
Brugia malayi G protein-coupled receptor F59B2.13 0.0022 0.017 0.017
Echinococcus granulosus serotonin receptor 0.0022 0.017 0.0276
Brugia malayi G protein-coupled receptor 0.0022 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0022 0.017 0.0276
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0012 0.002
Brugia malayi Doublecortin family protein 0.0019 0.013 0.013
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0214 0.0116
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0214 0.0116
Trypanosoma brucei C-8 sterol isomerase, putative 0.074 1 1
Brugia malayi heat shock protein 90 0.0026 0.0214 0.0214
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.017 0.0276
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Trypanosoma cruzi DNA topoisomerase II, putative 0.0026 0.0214 0.0116
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.017 0.0276
Echinococcus multilocularis cpg binding protein 0.003 0.0273 0.0444
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0026 0.0214 1
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0026 0.0214 0.5
Brugia malayi hypothetical protein 0.0022 0.017 0.017
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.017 0.0276
Plasmodium falciparum DNA topoisomerase 2 0.0026 0.0214 1
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.3351 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0022 0.017 0.0791
Echinococcus granulosus tachykinin peptides receptor 99D 0.0022 0.017 0.0276
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0026 0.0214 1
Echinococcus multilocularis glutamate receptor 2 0.0011 0.0012 0.002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.017 0.0276
Brugia malayi Melatonin receptor type 1A 0.0022 0.017 0.017
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2152 0.6177
Echinococcus granulosus neuropeptide receptor 0.0022 0.017 0.0276
Schistosoma mansoni endoplasmin 0.0026 0.0214 0.0347
Toxoplasma gondii heat shock protein 90, putative 0.0026 0.0214 0.0497
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Schistosoma mansoni cpg binding protein 0.003 0.0273 0.0444
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.2275 0.657
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0012 0.002
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.017 0.0276
Schistosoma mansoni cpg binding protein 0.003 0.0273 0.0444
Schistosoma mansoni pyruvate dehydrogenase 0.0434 0.581 0.9431
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0026 0.0214 0.0116
Mycobacterium tuberculosis Conserved protein 0.0026 0.0214 1
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0152 0.1946 0.1866
Echinococcus granulosus G protein coupled receptor 139 0.0022 0.017 0.0276
Leishmania major heat shock protein 83-1 0.0026 0.0214 0.0116
Schistosoma mansoni loxhd1 0.0019 0.013 0.0211
Schistosoma mansoni biogenic amine receptor 0.0022 0.017 0.0276
Echinococcus multilocularis orexin receptor type 2 0.0022 0.017 0.0276
Leishmania major heat shock protein 83-1 0.0026 0.0214 0.0116
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Schistosoma mansoni opsin-like receptor 0.0022 0.017 0.0276
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.017 0.0276
Onchocerca volvulus 0.0022 0.017 0.0791
Echinococcus multilocularis G-protein coupled receptor, putative 0.0022 0.017 0.0276
Onchocerca volvulus 0.0022 0.017 0.0791
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.017 0.0276
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.017 0.0276
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0026 0.0214 1
Echinococcus multilocularis tumor protein p63 0.0333 0.4426 0.7186
Schistosoma mansoni alpha-1 adrenergic receptor 0.0022 0.017 0.0276
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.017 0.0276
Echinococcus granulosus sex peptide receptor 0.0022 0.017 0.0276
Onchocerca volvulus 0.0019 0.013 0.0603
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Brugia malayi Serotonin receptor 0.0022 0.017 0.017
Echinococcus multilocularis mitogen activated protein kinase 14 0.0152 0.1946 0.3159
Mycobacterium ulcerans two component regulator - sensor kinase 0.0026 0.0214 0.4919
Loa Loa (eye worm) hypothetical protein 0.046 0.616 0.616
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0026 0.0214 1
Onchocerca volvulus 0.0022 0.017 0.0791
Echinococcus granulosus allatostatin A receptor 0.0022 0.017 0.0276
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0026 0.0214 0.0497
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0026 0.0214 0.5
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0026 0.0214 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0022 0.017 0.0276
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0161 0.2065 0.8488
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.2275 0.657
Leishmania major heat shock protein 83-1 0.0026 0.0214 0.0116
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0022 0.017 0.0276
Brugia malayi follicle stimulating hormone receptor 0.0249 0.3276 0.3276
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0333 0.0237
Leishmania major heat shock protein 83-1 0.0026 0.0214 0.0116
Onchocerca volvulus 0.0022 0.017 0.0791
Brugia malayi ORL1-like opioid receptor 0.0022 0.017 0.017
Onchocerca volvulus 0.0022 0.017 0.0791
Brugia malayi G-protein coupled receptor 0.0022 0.017 0.017
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.017 0.0276
Echinococcus granulosus orexin receptor type 2 0.0022 0.017 0.0276
Mycobacterium leprae Probable two-component sensor kinase 0.0026 0.0214 1
Onchocerca volvulus 0.0049 0.0531 0.247
Brugia malayi larval opioid receptor 0.0022 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0022 0.017 0.017
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0026 0.0214 0.4919
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0022 0.017 0.0276
Leishmania major heat shock protein 83-1 0.0026 0.0214 0.0116
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0026 0.0214 0.4919
Echinococcus granulosus nmda type glutamate receptor 0.0026 0.0214 0.0347
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0022 0.017 0.0276
Entamoeba histolytica hypothetical protein 0.0035 0.0339 1
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0026 0.0214 0.0214
Schistosoma mansoni hypothetical protein 0.0022 0.017 0.0276
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2152 0.6177
Onchocerca volvulus 0.0028 0.0251 0.1168
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0022 0.017 0.0276
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.013 0.0211
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0026 0.0214 0.4919
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Brugia malayi Probable DNA topoisomerase II 0.0026 0.0214 0.0214
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.017 0.0276
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.017 0.017
Onchocerca volvulus 0.0022 0.017 0.0791
Schistosoma mansoni polycystin 1-related 0.0019 0.013 0.0211
Schistosoma mansoni rab6-interacting 0.0019 0.013 0.0211
Schistosoma mansoni DNA topoisomerase II 0.0026 0.0214 0.0347
Echinococcus multilocularis neuropeptide receptor 0.0022 0.017 0.0276
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0022 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0026 0.0214 0.0214
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0011 0.0012 0.002
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.046 0.616 1
Leishmania major developmentally regulated phosphoprotein-like protein 0.046 0.616 0.6122
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.017 0.0276
Leishmania major heat shock protein 83-1 0.0026 0.0214 0.0116
Brugia malayi Cytochrome P450 family protein 0.0054 0.0603 0.0603
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.017 0.0276
Echinococcus granulosus g protein coupled receptor 0.0022 0.017 0.0276
Schistosoma mansoni heat shock protein 0.0026 0.0214 0.0347
Brugia malayi hypothetical protein 0.0022 0.017 0.017
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0022 0.017 0.0276
Trypanosoma brucei cytochrome P450, putative 0.0034 0.0333 0.0237
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.017 0.0276
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.013 0.0211
Brugia malayi Dopamine receptor protein 2 0.0022 0.017 0.017
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2152 0.6177
Giardia lamblia Pms1-like protein 0.0026 0.0214 0.5
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0026 0.0214 0.0116
Echinococcus multilocularis somatostatin receptor 0.0022 0.017 0.0276
Echinococcus multilocularis heat shock protein 90 0.0026 0.0214 0.0347
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0026 0.0214 0.0347
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.017 0.0276
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0686 0.1114
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0152 0.1946 0.1866
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0034 0.0333 1
Echinococcus multilocularis g-protein coupled receptor 0.0022 0.017 0.0276
Brugia malayi hypothetical protein 0.0019 0.013 0.013
Mycobacterium ulcerans putative regultory protein 0.0026 0.0214 0.4919
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0026 0.0214 0.0994
Echinococcus granulosus RUN 0.0019 0.013 0.0211
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0161 0.2065 0.1986
Schistosoma mansoni hypothetical protein 0.0035 0.0339 0.0551
Schistosoma mansoni lipoxygenase 0.0081 0.0977 0.1586
Echinococcus granulosus neuropeptide FF receptor 2 0.0022 0.017 0.0276
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.017 0.0276
Echinococcus granulosus neuropeptide s receptor 0.0022 0.017 0.0276
Toxoplasma gondii DNA topoisomerase 2, putative 0.0026 0.0214 0.0497
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2152 0.6177
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Trypanosoma brucei heat shock protein, putative 0.0026 0.0214 0.0116
Schistosoma mansoni histamine h1 receptor 0.0022 0.017 0.0276
Mycobacterium ulcerans DNA gyrase subunit B 0.0026 0.0214 0.4919
Onchocerca volvulus Neuropeptide F receptor homolog 0.0022 0.017 0.0791
Schistosoma mansoni biogenic amine (5HT) receptor 0.0378 0.5043 0.8187
Schistosoma mansoni opsin-like receptor 0.0022 0.017 0.0276
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0022 0.017 0.0276
Brugia malayi Serotonin receptor 0.0022 0.017 0.017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.017 0.0276
Loa Loa (eye worm) hypothetical protein 0.0378 0.5044 0.5044
Echinococcus granulosus mitogen activated protein kinase 11 0.0152 0.1946 0.3159
Onchocerca volvulus 0.0022 0.017 0.0791
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0022 0.017 0.0276
Echinococcus granulosus heat shock protein 90 0.0026 0.0214 0.0347
Echinococcus multilocularis nmda type glutamate receptor 0.0026 0.0214 0.0347
Brugia malayi AKH receptor 0.0022 0.017 0.017
Trypanosoma brucei DNA topoisomerase ii 0.0026 0.0214 0.0116
Brugia malayi P38 map kinase family protein 2 0.0152 0.1946 0.1946
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.017 0.0276
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.5387 0.8745
Leishmania major C-8 sterol isomerase-like protein 0.074 1 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0012 0.002
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0026 0.0214 0.0347
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0255 0.3351 0.3351
Schistosoma mansoni hypothetical protein 0.0022 0.017 0.0276
Schistosoma mansoni lipoxygenase 0.0116 0.1456 0.2364
Trypanosoma cruzi DNA topoisomerase II, putative 0.0026 0.0214 0.0116
Brugia malayi hypothetical protein 0.0022 0.017 0.017
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0026 0.0214 0.4919
Echinococcus multilocularis neuropeptide receptor 0.0022 0.017 0.0276
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0022 0.017 0.0276
Echinococcus multilocularis sex peptide receptor 0.0022 0.017 0.0276
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.017 0.0276
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.046 0.616 0.6122
Brugia malayi neuropeptide F receptor 0.0022 0.017 0.017
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0022 0.017 0.017
Loa Loa (eye worm) melatonin receptor type 1A 0.0022 0.017 0.017
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0161 0.2065 0.1986
Brugia malayi hypothetical protein 0.0019 0.013 0.013
Schistosoma mansoni biogenic amine receptor 0.0022 0.017 0.0276
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.017 0.017
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.017 0.0276
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Echinococcus multilocularis RUN 0.0019 0.013 0.0211
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0333 0.0237
Schistosoma mansoni amine GPCR 0.0022 0.017 0.0276
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0026 0.0214 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.013 0.0211
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0214 0.0116
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.017 0.0276
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.013
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.017 0.0276
Brugia malayi Dopamine receptor protein 1 0.0022 0.017 0.017
Schistosoma mansoni opsin-like receptor 0.0022 0.017 0.0276
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0333 0.0333
Schistosoma mansoni amine GPCR 0.0022 0.017 0.0276
Leishmania major DNA topoisomerase ii 0.0026 0.0214 0.0116
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Schistosoma mansoni rab6-interacting 0.0019 0.013 0.0211
Trypanosoma cruzi Heat shock protein 83, putative 0.0026 0.0214 0.0116
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.017 0.0276
Plasmodium falciparum DNA gyrase subunit B 0.0026 0.0214 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Trypanosoma brucei heat shock protein, putative 0.0026 0.0214 0.0116
Plasmodium vivax heat shock protein 86, putative 0.0026 0.0214 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Leishmania major heat shock protein 83-1 0.0026 0.0214 0.0116
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.3351 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0022 0.017 0.0276
Onchocerca volvulus 0.0022 0.017 0.0791
Trypanosoma brucei developmentally regulated phosphoprotein 0.046 0.616 0.6122
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0026 0.0214 0.0116
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0026 0.0214 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Plasmodium falciparum heat shock protein 90 0.0026 0.0214 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0339 0.0551
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.017
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.017 0.0276

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 60 nM In vitro inhibition of mitogen-activated protein kinase p38 alpha 2 derived from E. coli ChEMBL. 11140741
IC50 (binding) = 60 nM In vitro inhibition of mitogen-activated protein kinase p38 alpha 2 derived from E. coli ChEMBL. 11140741
Inhibition (binding) = 85 % Percent inhibition determined in vitro against mitogen-activated protein kinase p38 alpha 2 derived from E. coli at 5 microM. ChEMBL. 11140741
Inhibition (binding) = 85 % Percent inhibition determined in vitro against mitogen-activated protein kinase p38 alpha 2 derived from E. coli at 5 microM. ChEMBL. 11140741

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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