Detailed information for compound 211967

Basic information

Technical information
  • TDR Targets ID: 211967
  • Name: N-(cyanomethyl)-4-methyl-2-[3-(4-methylsulfon ylphenyl)phenyl]pentanamide
  • MW: 384.492 | Formula: C21H24N2O3S
  • H donors: 1 H acceptors: 4 LogP: 3.51 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CCNC(=O)C(c1cccc(c1)c1ccc(cc1)S(=O)(=O)C)CC(C)C
  • InChi: 1S/C21H24N2O3S/c1-15(2)13-20(21(24)23-12-11-22)18-6-4-5-17(14-18)16-7-9-19(10-8-16)27(3,25)26/h4-10,14-15,20H,12-13H2,1-3H3,(H,23,24)
  • InChiKey: ZLPAZVDKFDGTOW-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-(cyanomethyl)-2-[3-(4-mesylphenyl)phenyl]-4-methyl-valeramide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin S Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni notch 0.0165 0.2347 0.2347
Echinococcus granulosus neurogenic locus notch protein 0.0165 0.2347 0.2347
Brugia malayi Peroxidasin 0.0512 1 1
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0165 0.2347 0.2347
Onchocerca volvulus 0.0165 0.2347 0.2347
Brugia malayi EGF-like domain containing protein 0.0165 0.2347 0.2347
Brugia malayi EGF-like domain containing protein 0.0165 0.2347 0.2347
Echinococcus multilocularis neurogenic locus notch protein 0.0165 0.2347 0.1866
Plasmodium vivax vivapain-2 0.0086 0.0591 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0591 1
Echinococcus multilocularis fibropellin Ia 0.0165 0.2347 0.1866
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0591 1
Brugia malayi Cathepsin L-like precursor 0.0086 0.0591 0.0591
Leishmania major cathepsin L-like protease 0.0086 0.0591 1
Schistosoma mansoni hypothetical protein 0.0165 0.2347 0.2347
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0591 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0591 1
Brugia malayi Animal haem peroxidase family protein 0.0512 1 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.2347 0.2347
Onchocerca volvulus Cathepsin L homolog 0.0086 0.0591 0.0591
Onchocerca volvulus Dual oxidase homolog 0.0512 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0591 1
Onchocerca volvulus 0.0165 0.2347 0.2347
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0591 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0591 1
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.0591 0.2198
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0086 0.0591 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0591 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.2687 0.2687
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0591 1
Schistosoma mansoni hypothetical protein 0.0165 0.2347 0.2347
Echinococcus multilocularis protein jagged 2 0.0165 0.2347 0.1866
Echinococcus multilocularis notch 0.0165 0.2347 0.1866
Leishmania major cathepsin L-like protease 0.0086 0.0591 1
Loa Loa (eye worm) cathepsin B 0.007 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0165 0.2347 0.2347
Loa Loa (eye worm) hypothetical protein 0.0165 0.2347 0.2347
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.2687 0.2687
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0591 1
Echinococcus granulosus delta-like protein 1 0.0165 0.2347 0.2347
Entamoeba histolytica cysteine protease, putative 0.0086 0.0591 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.2347 0.2347
Onchocerca volvulus Chorion peroxidase homolog 0.0512 1 1
Schistosoma mansoni peroxidasin 0.0512 1 1
Loa Loa (eye worm) hypothetical protein 0.0512 1 1
Echinococcus granulosus protein jagged 2 0.0165 0.2347 0.2347
Onchocerca volvulus 0.0086 0.0591 0.0591
Brugia malayi Blistered cuticle protein 3 0.0512 1 1
Brugia malayi Cathepsin L-like precursor 0.0086 0.0591 0.0591
Brugia malayi Animal haem peroxidase family protein 0.0512 1 1
Brugia malayi EGF-like domain containing protein 0.0165 0.2347 0.2347
Giardia lamblia High cysteine protein 0.0165 0.2347 1
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.0591 0.2198
Toxoplasma gondii cathepsin CPL 0.0086 0.0591 0.1693
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0591 1
Loa Loa (eye worm) hypothetical protein 0.0512 1 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.2347 0.2347
Schistosoma mansoni hypothetical protein 0.0165 0.2347 0.2347
Loa Loa (eye worm) hypothetical protein 0.0512 1 1
Brugia malayi EGF-like domain containing protein 0.0165 0.2347 0.2347
Echinococcus multilocularis cathepsin b 0.0181 0.2687 0.2228
Schistosoma mansoni notch 0.0165 0.2347 0.2347
Loa Loa (eye worm) hypothetical protein 0.0165 0.2347 0.2347
Leishmania major cathepsin L-like protease 0.0086 0.0591 1
Loa Loa (eye worm) fibroinase 0.0086 0.0591 0.0591
Echinococcus granulosus neurogenic locus protein delta 0.0165 0.2347 0.2347
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.007 0.0233 0.0866
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.0591 0.2198
Loa Loa (eye worm) blistered cuticle protein 3 0.0512 1 1
Plasmodium vivax vivapain-2 0.0086 0.0591 0.5
Echinococcus multilocularis protein jagged 1 0.0165 0.2347 0.1866
Leishmania major cathepsin L-like protease 0.0086 0.0591 1
Onchocerca volvulus 0.0086 0.0591 0.0591
Loa Loa (eye worm) hypothetical protein 0.0512 1 1
Loa Loa (eye worm) hypothetical protein 0.0512 1 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.2347 0.2347
Loa Loa (eye worm) hypothetical protein 0.0165 0.2347 0.2347
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0591 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.2347 0.2347
Brugia malayi Calcium binding EGF domain containing protein 0.0165 0.2347 0.2347
Trypanosoma cruzi cruzipain precursor, putative 0.0086 0.0591 0.2198
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0591 1
Loa Loa (eye worm) hypothetical protein 0.0512 1 1
Onchocerca volvulus 0.0086 0.0591 0.0591
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0591 1
Schistosoma mansoni hypothetical protein 0.0165 0.2347 0.2347
Echinococcus granulosus slit 2 protein 0.0165 0.2347 0.2347
Loa Loa (eye worm) hypothetical protein 0.0165 0.2347 0.2347
Onchocerca volvulus Peroxidase homolog 0.0512 1 1
Loa Loa (eye worm) hypothetical protein 0.0512 1 1
Echinococcus granulosus protein jagged 2 0.0165 0.2347 0.2347
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0591 1
Loa Loa (eye worm) hypothetical protein 0.0512 1 1
Brugia malayi Calcium binding EGF domain containing protein 0.0165 0.2347 0.2347
Onchocerca volvulus 0.0165 0.2347 0.2347
Onchocerca volvulus Cathepsin F homolog 0.0086 0.0591 0.0591
Loa Loa (eye worm) animal heme peroxidase 0.0512 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0591 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0591 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.2347 0.2347
Onchocerca volvulus Slit protein homolog 0.0165 0.2347 0.2347
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0181 0.2687 1
Echinococcus multilocularis neurogenic locus notch protein 4 0.0165 0.2347 0.1866
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0591 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0591 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0181 0.2687 0.2687
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.007 0.0233 0.0233
Schistosoma mansoni laminin gamma-3 chain 0.0165 0.2347 0.2347
Schistosoma mansoni hypothetical protein 0.0165 0.2347 0.2347
Echinococcus multilocularis neurogenic locus notch protein 0.0165 0.2347 0.1866
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0591 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.2347 0.2347
Schistosoma mansoni notch 0.0165 0.2347 0.2347
Loa Loa (eye worm) hypothetical protein 0.0512 1 1
Echinococcus granulosus cathepsin l1 0.0086 0.0591 0.0591
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0591 1
Echinococcus multilocularis cathepsin b 0.0181 0.2687 0.2228
Brugia malayi EGF-like domain containing protein 0.0165 0.2347 0.2347
Onchocerca volvulus Cathepsin L homolog 0.0086 0.0591 0.0591
Loa Loa (eye worm) hypothetical protein 0.0181 0.2687 0.2687
Onchocerca volvulus 0.0086 0.0591 0.0591
Echinococcus granulosus peroxidasin 0.0512 1 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.2347 0.2347
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0591 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.2347 0.2347
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0591 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0591 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.2347 0.2347
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0165 0.2347 0.2347
Onchocerca volvulus Putative cubilin 0.0165 0.2347 0.2347
Brugia malayi EGF-like domain containing protein 0.0165 0.2347 0.2347
Plasmodium falciparum cysteine proteinase falcipain 3 0.0086 0.0591 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0.2347 0.2347
Echinococcus multilocularis neurogenic locus protein delta 0.0165 0.2347 0.1866
Echinococcus granulosus cathepsin b 0.0181 0.2687 0.2687
Loa Loa (eye worm) hypothetical protein 0.0165 0.2347 0.2347
Echinococcus multilocularis slit 2 protein 0.0165 0.2347 0.1866
Onchocerca volvulus 0.0512 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.0591 0.0591
Onchocerca volvulus 0.0165 0.2347 0.2347
Brugia malayi EGF-like domain containing protein 0.0165 0.2347 0.2347
Schistosoma mansoni hypothetical protein 0.0165 0.2347 0.2347
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0086 0.0591 0.0591
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.007 0.0233 0.394
Brugia malayi Cathepsin L-like precursor 0.0086 0.0591 0.0591
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0591 1
Onchocerca volvulus Peroxidasin homolog 0.0512 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0086 0.0591 0.0591
Onchocerca volvulus Peroxidase homolog 0.0512 1 1
Brugia malayi notch-like transmembrane receptor 0.0165 0.2347 0.2347
Echinococcus multilocularis neural cadherin 0.0165 0.2347 0.1866
Leishmania major cysteine peptidase A (CPA) 0.0086 0.0591 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.0591 1
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.0591 0.0591
Brugia malayi cathepsin B-like cysteine proteinase 0.0181 0.2687 0.2687
Schistosoma mansoni slit 0.0165 0.2347 0.2347
Echinococcus granulosus fibropellin Ia 0.0165 0.2347 0.2347
Leishmania major cathepsin L-like protease 0.0086 0.0591 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0591 1
Brugia malayi Muscle positioning protein 4 0.0165 0.2347 0.2347
Brugia malayi Cadherin domain containing protein 0.0165 0.2347 0.2347
Echinococcus granulosus neurogenic locus notch protein 4 0.0165 0.2347 0.2347
Loa Loa (eye worm) hypothetical protein 0.0512 1 1
Loa Loa (eye worm) notch protein 0.0165 0.2347 0.2347
Loa Loa (eye worm) hypothetical protein 0.0512 1 1
Schistosoma mansoni septate junction protein 0.0165 0.2347 0.2347
Onchocerca volvulus Peroxidasin homolog 0.0512 1 1
Echinococcus multilocularis protein jagged 1 0.0165 0.2347 0.1866
Echinococcus multilocularis fat cadherin tumor suppressor 0.0165 0.2347 0.1866
Loa Loa (eye worm) ctsf protein 0.0086 0.0591 0.0591
Loa Loa (eye worm) hypothetical protein 0.0165 0.2347 0.2347
Echinococcus granulosus cathepsin l cysteine peptidase 0.0086 0.0591 0.0591
Leishmania major cathepsin L-like protease 0.0086 0.0591 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0086 0.0591 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0591 1
Loa Loa (eye worm) cysteine protease 0.0086 0.0591 0.0591
Brugia malayi Papain family cysteine protease containing protein 0.0086 0.0591 0.0591
Schistosoma mansoni notch 0.0165 0.2347 0.2347
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0086 0.0591 0.0591
Brugia malayi Animal haem peroxidase family protein 0.0512 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0591 1
Echinococcus granulosus protein jagged 1 0.0165 0.2347 0.2347
Loa Loa (eye worm) animal heme peroxidase 0.0512 1 1
Brugia malayi Cadherin domain containing protein 0.0165 0.2347 0.2347
Onchocerca volvulus 0.0512 1 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.2347 0.2347
Echinococcus granulosus neurogenic locus notch protein 0.0165 0.2347 0.2347
Echinococcus granulosus cathepsin b 0.0181 0.2687 0.2687
Onchocerca volvulus 0.0086 0.0591 0.0591
Schistosoma mansoni notch 0.0165 0.2347 0.2347
Schistosoma mansoni notch 0.0165 0.2347 0.2347
Schistosoma mansoni peroxidasin 0.0512 1 1
Brugia malayi Cathepsin L-like precursor 0.0086 0.0591 0.0591
Onchocerca volvulus 0.0086 0.0591 0.0591
Loa Loa (eye worm) hypothetical protein 0.0512 1 1
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0165 0.2347 0.2347
Brugia malayi Delta serrate ligand family protein 0.0165 0.2347 0.2347
Loa Loa (eye worm) animal heme peroxidase 0.0512 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0591 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0591 0.0591
Brugia malayi Animal haem peroxidase family protein 0.0512 1 1
Schistosoma mansoni hypothetical protein 0.0165 0.2347 0.2347
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0591 1
Echinococcus multilocularis neurogenic locus protein delta 0.0165 0.2347 0.1866
Onchocerca volvulus Neurogenic locus notch homolog 0.0165 0.2347 0.2347
Onchocerca volvulus 0.0512 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.0591 1
Loa Loa (eye worm) hypothetical protein 0.0512 1 1
Brugia malayi Animal haem peroxidase family protein 0.0512 1 1
Brugia malayi GCC2 and GCC3 family protein 0.0165 0.2347 0.2347
Leishmania major cathepsin L-like protease 0.0086 0.0591 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0591 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0591 1
Loa Loa (eye worm) animal heme peroxidase 0.0512 1 1
Onchocerca volvulus 0.0086 0.0591 0.0591
Leishmania major cathepsin L-like protease 0.0086 0.0591 1
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.0591 1
Echinococcus multilocularis peroxidasin 0.0512 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.0591 0.2198
Onchocerca volvulus 0.0165 0.2347 0.2347
Echinococcus granulosus neural cadherin 0.0165 0.2347 0.2347
Schistosoma mansoni cell polarity protein 0.0165 0.2347 0.2347
Loa Loa (eye worm) hypothetical protein 0.0165 0.2347 0.2347
Brugia malayi Cathepsin L-like precursor 0.0086 0.0591 0.0591
Echinococcus granulosus notch 0.0165 0.2347 0.2347
Echinococcus granulosus protein jagged 1 0.0165 0.2347 0.2347
Loa Loa (eye worm) Notch2 0.0165 0.2347 0.2347
Brugia malayi Cathepsin L-like precursor 0.0086 0.0591 0.0591
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.0591 1
Toxoplasma gondii EGF family domain-containing protein 0.0165 0.2347 1
Loa Loa (eye worm) hypothetical protein 0.0512 1 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.2347 0.2347
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.2687 0.2687
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0591 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.2347 0.2347
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0591 1
Brugia malayi Calcium binding EGF domain containing protein 0.0165 0.2347 0.2347

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1227 nM In vitro inhibitory activity against human cathepsin K, using 2 microM of Z -Leu-Arg-AMC as substrate ChEMBL. 12904076
IC50 (binding) = 1227 nM In vitro inhibitory activity against human cathepsin K, using 2 microM of Z -Leu-Arg-AMC as substrate ChEMBL. 12904076
IC50 (binding) = 6623 nM In vitro inhibitory activity against human cathepsin S, using 2 microM of Z -Leu-Arg-AMC as substrate ChEMBL. 12904076
IC50 (binding) = 6623 nM In vitro inhibitory activity against human cathepsin S, using 2 microM of Z -Leu-Arg-AMC as substrate ChEMBL. 12904076
IC50 (binding) > 10000 nM In vitro inhibitory activity against human cathepsin L, using 2 microM of Z -Leu-Arg-AMC as substrate ChEMBL. 12904076
IC50 (binding) > 10000 nM In vitro inhibitory activity against human cathepsin B, using 2 microM of Z -Leu-Arg-AMC as substrate ChEMBL. 12904076
IC50 (binding) > 10000 nM In vitro inhibitory activity against human cathepsin L, using 2 microM of Z -Leu-Arg-AMC as substrate ChEMBL. 12904076
IC50 (binding) > 10000 nM In vitro inhibitory activity against human cathepsin B, using 2 microM of Z -Leu-Arg-AMC as substrate ChEMBL. 12904076

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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