TDR Targets

Basic information

Technical information

TDR Targets ID: 213747
Name: 6-(cyclohexylmethoxy)-N-(3,5-dichlorophenyl)- 7H-purin-2-amine
MW: 392.282 | Formula: C18H19Cl2N5O
H donors: 2 H acceptors: 3 LogP: 5.91 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cc(cc(c1)Cl)Nc1nc(OCC2CCCCC2)c2c(n1)nc[nH]2
InChi: 1S/C18H19Cl2N5O/c19-12-6-13(20)8-14(7-12)23-18-24-16-15(21-10-22-16)17(25-18)26-9-11-4-2-1-3-5-11/h6-8,10-11H,1-5,9H2,(H2,21,22,23,24,25)
InChiKey: YCWZCGXPKQMJLT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[6-(cyclohexylmethoxy)-7H-purin-2-yl]-(3,5-dichlorophenyl)amine
O6-Cyclohexylmethylguanine deriv. 18

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cyclin B3	Starlite/ChEMBL	References
Homo sapiens	cyclin B2	Starlite/ChEMBL	References
Homo sapiens	cyclin A1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Giardia lamblia	G2/mitotic-specific cyclin B	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma congolense	Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Onchocerca volvulus		Get druggable targets OG5_126649	All targets in OG5_126649
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126649	All targets in OG5_126649
Schistosoma mansoni	cyclin B3	Get druggable targets OG5_134175	All targets in OG5_134175
Leishmania major	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Schistosoma japonicum	ko:K05868 cyclin B, putative	Get druggable targets OG5_134175	All targets in OG5_134175
Brugia malayi	Cyclin, N-terminal domain containing protein	Get druggable targets OG5_134175	All targets in OG5_134175
Echinococcus multilocularis	G2:mitotic specific cyclin B3	Get druggable targets OG5_134175	All targets in OG5_134175
Leishmania infantum	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania mexicana	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Candida albicans	hypothetical protein	Get druggable targets OG5_126649	All targets in OG5_126649
Brugia malayi	Cyclin, N-terminal domain containing protein	Get druggable targets OG5_126649	All targets in OG5_126649
Candida albicans	likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction	Get druggable targets OG5_126649	All targets in OG5_126649
Cryptosporidium hominis	mitotic cyclin-CYC2	Get druggable targets OG5_126649	All targets in OG5_126649
Brugia malayi	Cyclin, N-terminal domain containing protein	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclins, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Candida albicans	likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclins, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclin B, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclin B, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Loa Loa (eye worm)	cyclin domain-containing protein	Get druggable targets OG5_134175	All targets in OG5_134175
Echinococcus multilocularis	cyclin B	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclin B, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma cruzi	CYC2-like cyclin, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Echinococcus granulosus	cyclin B	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania infantum	CYC2-like cyclin, putative,cyclin 6, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Echinococcus granulosus	G2:mitotic specific cyclin B3	Get druggable targets OG5_134175	All targets in OG5_134175
Leishmania mexicana	CYC2-like cyclin, putative,cyclin 6, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma brucei	mitotic cyclin 6	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclins, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania braziliensis	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma cruzi	cyclin, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania donovani	CYC2-like cyclin, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclins, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma cruzi	cyclin, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania braziliensis	CYC2-like cyclin, putative,cyclin 6, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma brucei gambiense	cyclin 6,mitotic cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania donovani	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma cruzi	cyclin 6, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Schistosoma mansoni	cyclin B	Get druggable targets OG5_126649	All targets in OG5_126649
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126649	All targets in OG5_126649
Entamoeba histolytica	cyclin, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Schistosoma japonicum	ko:K05868 cyclin B, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclin B, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Cryptosporidium parvum	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Schistosoma japonicum	IPR002155,Thiolase,domain-containing	Get druggable targets OG5_134175	All targets in OG5_134175
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclin A, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma congolense	mitotic cyclin 6	Get druggable targets OG5_126649	All targets in OG5_126649
Candida albicans	likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclins, putative	Get druggable targets OG5_126649	All targets in OG5_126649

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0055	0.1002	0.3747
Brugia malayi	nuclear receptor RXR	0.001	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0024	0.0024
Echinococcus multilocularis	cyclin k	0.0016	0.0163	0.0311
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0019	0.0238	0.0238
Trypanosoma cruzi	cyclin, putative	0.0124	0.2483	1
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.1002	0.4037
Schistosoma mansoni	voltage-gated potassium channel	0.0043	0.0757	0.186
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0047	0.0047
Echinococcus granulosus	survival motor neuron protein 1	0.0255	0.5261	1
Schistosoma mansoni	ankyrin 23/unc44	0.0015	0.0162	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0024	0.0024
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.001	0.0047	0.0089
Trichomonas vaginalis	cyclin B, putative	0.0064	0.1204	0.4849
Brugia malayi	Cyclin C	0.0016	0.0163	0.0163
Brugia malayi	Nuclear hormone receptor-like 1	0.0019	0.0238	0.0238
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0124	0.2483	1
Echinococcus multilocularis	cyclin G2	0.0016	0.0163	0.0311
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0115	0.0115
Echinococcus granulosus	cyclins	0.0064	0.1204	0.2288
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0016	0.0163	0.0163
Brugia malayi	photoreceptor-specific nuclear receptor	0.0019	0.0238	0.0238
Echinococcus multilocularis	nuclear receptor nhr 48	0.0009	0.0024	0.0046
Echinococcus granulosus	cyclin t1	0.0016	0.0163	0.0311
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0009	0.0024	0.0046
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0019	0.0238	0.0586
Echinococcus multilocularis	cyclins	0.0064	0.1204	0.2288
Schistosoma mansoni	hypothetical protein	0.0016	0.0163	0.0402
Schistosoma mansoni	lozenge	0.006	0.1108	0.2723
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.1002	0.4037
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0012	0.0078	0.0078
Loa Loa (eye worm)	hypothetical protein	0.001	0.0047	0.0047
Echinococcus granulosus	cyclin G2	0.0016	0.0163	0.0311
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0019	0.0238	0.0238
Brugia malayi	follicle stimulating hormone receptor	0.0249	0.5149	0.5149
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0238	0.0238
Onchocerca volvulus		0.0052	0.094	0.0918
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0012	0.0078	0.0148
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0009	0.0024	0.0046
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0019	0.0238	0.0238
Schistosoma mansoni	cyclin l	0.0016	0.0163	0.0402
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0047	0.0115
Schistosoma mansoni	thyroid hormone receptor	0.0019	0.0238	0.0586
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0199	0.4069	0.4069
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0019	0.0238	0.0238
Echinococcus multilocularis	Cyclin L1	0.0016	0.0163	0.0311
Echinococcus multilocularis	cyclin b3	0.0064	0.1204	0.2288
Brugia malayi	hypothetical protein	0.0016	0.0163	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0024	0.0024
Trichomonas vaginalis	cyclins, putative	0.0124	0.2483	1
Schistosoma mansoni	cyclin G2	0.0016	0.0163	0.0402
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0019	0.0238	0.0453
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0009	0.0024	0.0024
Echinococcus multilocularis	cyclins	0.0064	0.1204	0.2288
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0015	0.0162	0.0309
Brugia malayi	hypothetical protein	0.0024	0.0354	0.0354
Brugia malayi	nuclear receptor NHR-88	0.0009	0.0024	0.0024
Brugia malayi	hypothetical protein	0.0016	0.0169	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0255	0.5261	0.5261
Schistosoma mansoni	cyclin k	0.0016	0.0163	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0238	0.0238
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0019	0.0238	0.0238
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.1204	0.4849
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0238	0.0238
Trypanosoma cruzi	mitotic cyclin, putative	0.0016	0.0163	0.0205
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0249	0.5149	0.5149
Brugia malayi	Death domain containing protein	0.0015	0.0162	0.0162
Trichomonas vaginalis	cyclins, putative	0.0124	0.2483	1
Trichomonas vaginalis	cyclin B, putative	0.0124	0.2483	1
Schistosoma mansoni	voltage-gated potassium channel	0.0043	0.0757	0.186
Loa Loa (eye worm)	cyclin domain-containing protein	0.0016	0.0163	0.0163
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0016	0.0165	0.0406
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0009	0.0024	0.0046
Trypanosoma brucei	mitotic cyclin	0.0016	0.0163	0.0205
Echinococcus multilocularis	cyclins	0.0064	0.1204	0.2288
Brugia malayi	Steroid receptor seven-up type 2	0.0019	0.0238	0.0238
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.1002	0.4037
Echinococcus granulosus	cyclin B3 1	0.0064	0.1204	0.2288
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0055	0.1002	0.1002
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0016	0.0163	0.0163
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0019	0.0238	0.0453
Onchocerca volvulus	Netrin receptor homolog	0.0015	0.0162	0.0139
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0354	0.1012
Echinococcus multilocularis	oligomeric golgi complex subunit 3	0.0016	0.0163	0.0311
Brugia malayi	Nuclear hormone receptor E75	0.0009	0.0024	0.0024
Entamoeba histolytica	cyclin family protein	0.0064	0.1204	0.4486
Echinococcus multilocularis	ecdysone induced protein 78C	0.0019	0.0238	0.0453
Trichomonas vaginalis	cyclins, putative	0.0124	0.2483	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0019	0.0238	0.0453
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0016	0.0163	0.0163
Loa Loa (eye worm)	CYP4Cod1	0.0013	0.0115	0.0115
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0019	0.0238	0.0238
Brugia malayi	hypothetical protein	0.001	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0024	0.0024
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0037	0.0623	0.2511
Echinococcus granulosus	cyclin k	0.0016	0.0163	0.0311
Echinococcus granulosus	cyclins	0.0064	0.1204	0.2288
Echinococcus multilocularis	cyclin	0.0016	0.0163	0.0311
Loa Loa (eye worm)	cyclin domain-containing protein	0.0016	0.0163	0.0163
Loa Loa (eye worm)	hypothetical protein	0.006	0.1111	0.1111
Schistosoma mansoni	netrin receptor unc5	0.0015	0.0162	0.0399
Brugia malayi	nuclear receptor RXR	0.0009	0.0024	0.0024
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0019	0.0238	0.0453
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0163	0.0658
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.004	0.0679	0.1291
Trichomonas vaginalis	cyclins, putative	0.0064	0.1204	0.4849
Echinococcus granulosus	cyclin A3 4	0.0016	0.0163	0.0311
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0019	0.0238	0.0238
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0015	0.0162	0.0162
Echinococcus multilocularis	cyclin B	0.0124	0.2483	0.4719
Loa Loa (eye worm)	cyclin fold protein 1 variant b	0.0016	0.0163	0.0163
Trypanosoma brucei	protein kinase, putative	0.0055	0.1002	0.3747
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0055	0.1002	0.3747
Loa Loa (eye worm)	cyclin domain-containing protein	0.0199	0.4069	0.4069
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0019	0.0238	0.0586
Loa Loa (eye worm)	cyclin domain-containing protein	0.0016	0.0163	0.0163
Echinococcus multilocularis	cyclin B3 1	0.0064	0.1204	0.2288
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0055	0.1002	0.3747
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0009	0.0024	0.0046
Loa Loa (eye worm)	cyclin domain-containing protein	0.0016	0.0163	0.0163
Schistosoma mansoni	voltage-gated potassium channel	0.0012	0.0078	0.0191
Trypanosoma brucei	mitotic cyclin 6	0.0124	0.2483	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0019	0.0238	0.0453
Trichomonas vaginalis	cyclin B, putative	0.0124	0.2483	1
Onchocerca volvulus	Cyclin L homolog	0.0016	0.0163	0.014
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0019	0.0238	0.0238
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0019	0.0238	0.0453
Echinococcus granulosus	cyclin G2	0.0016	0.0163	0.0311
Brugia malayi	nuclear receptor NHR-88	0.0019	0.0238	0.0238
Brugia malayi	nuclear hormone receptor	0.0009	0.0024	0.0024
Schistosoma mansoni	nuclear hormone receptor	0.0009	0.0024	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0238	0.0238
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0019	0.0238	0.0238
Schistosoma mansoni	hypothetical protein	0.0016	0.0163	0.0402
Trypanosoma cruzi	cyclin 9, putative	0.0016	0.0163	0.0205
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0163	0.0205
Loa Loa (eye worm)	steroid hormone receptor	0.0019	0.0238	0.0238
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0019	0.0238	0.0238
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0019	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0238	0.0238
Echinococcus granulosus	cyclin y	0.0016	0.0163	0.0311
Echinococcus granulosus	thyroid hormone receptor alpha	0.0009	0.0024	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0477	1	1
Schistosoma mansoni	hypothetical protein	0.0015	0.0162	0.0399
Echinococcus multilocularis	mitogen activated protein kinase	0.0055	0.1002	0.1905
Onchocerca volvulus		0.0477	1	1
Echinococcus multilocularis	Protein lozenge	0.006	0.1108	0.2106
Echinococcus multilocularis	G1:S specific cyclin D1	0.0016	0.0163	0.0311
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.004	0.0679	0.0679
Entamoeba histolytica	cyclin, putative	0.0064	0.1204	0.4486
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0199	0.4069	0.7735
Trichomonas vaginalis	cyclin B, putative	0.0124	0.2483	1
Schistosoma mansoni	cyclins	0.0064	0.1204	0.2958
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0019	0.0238	0.0453
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0019	0.0238	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0162	0.0162
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0019	0.0238	0.0586
Echinococcus multilocularis	cyclin y	0.0016	0.0163	0.0311
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0354	0.1012
Brugia malayi	hypothetical protein	0.0009	0.0024	0.0024
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0079	0.1523	0.2895
Echinococcus multilocularis	cyclin y	0.0016	0.0163	0.0311
Leishmania major	cyclin 9, putative	0.0016	0.0163	0.0205
Echinococcus granulosus	oligomeric golgi complex subunit 3	0.0016	0.0163	0.0311
Loa Loa (eye worm)	CYL-1 protein	0.0016	0.0163	0.0163
Echinococcus multilocularis	cyclin G2	0.0016	0.0163	0.0311
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0019	0.0238	0.0586
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0019	0.0238	0.0586
Brugia malayi	ecdysone receptor	0.0009	0.0024	0.0024
Echinococcus granulosus	mitogen activated protein kinase	0.0055	0.1002	0.1905
Brugia malayi	hypothetical protein	0.0009	0.0024	0.0024
Echinococcus multilocularis	cyclins	0.0064	0.1204	0.2288
Entamoeba histolytica	cyclin family protein	0.0064	0.1204	0.4486
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0052	0.094	0.094
Loa Loa (eye worm)	runx1	0.006	0.1108	0.1108
Toxoplasma gondii	hypothetical protein	0.0049	0.0873	0.8458
Echinococcus multilocularis	cyclin t1	0.0016	0.0163	0.0311
Echinococcus granulosus	cdk5 and abl1 enzyme substrate 1	0.0016	0.0163	0.0311
Giardia lamblia	Cyclin A	0.0064	0.1204	0.4486
Trichomonas vaginalis	cyclin B3, putative	0.0016	0.0163	0.0658
Echinococcus granulosus	mitogen activated protein kinase 3	0.0055	0.1002	0.1905
Schistosoma mansoni	retinoic acid receptor RXR	0.0019	0.0238	0.0586
Leishmania major	mitotic cyclin, putative	0.0016	0.0163	0.0205
Trypanosoma cruzi	cyclin, putative	0.0124	0.2483	1
Echinococcus granulosus	cyclins	0.0064	0.1204	0.2288
Schistosoma mansoni	cyclin B	0.0124	0.2483	0.6101
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0015	0.0162	0.0162
Schistosoma mansoni	cyclin G	0.0016	0.0163	0.0402
Trichomonas vaginalis	cyclin D, putative	0.0064	0.1204	0.4849
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0009	0.0024	0.0024
Onchocerca volvulus		0.0124	0.2483	0.2465
Schistosoma mansoni	coup transcription factor	0.0019	0.0238	0.0586
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0163	0.0658
Echinococcus multilocularis	voltage gated potassium channel	0.0012	0.0078	0.0148
Echinococcus multilocularis	Ankyrin	0.0016	0.0165	0.0314
Trichomonas vaginalis	cyclins, putative	0.0016	0.0163	0.0658
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0009	0.0024	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0163	0.0163
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0019	0.0238	0.0238
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.0354	0.2277
Echinococcus granulosus	netrin receptor unc 5	0.0015	0.0162	0.0309
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0055	0.1002	1
Echinococcus granulosus	cyclins	0.0016	0.0163	0.0311
Schistosoma mansoni	hypothetical protein	0.0052	0.094	0.2309
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0016	0.0163	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0078	0.0078
Trypanosoma brucei	cyclin 9	0.0016	0.0163	0.0205
Trichomonas vaginalis	cyclin D, putative	0.0016	0.0163	0.0658
Onchocerca volvulus	Protein CNPPD1 homolog	0.0016	0.0163	0.014
Brugia malayi	tailless protein	0.0009	0.0024	0.0024
Schistosoma mansoni	cyclin d	0.0016	0.0163	0.0402
Onchocerca volvulus		0.0016	0.0163	0.014
Echinococcus granulosus	ecdysone induced protein 78C	0.0019	0.0238	0.0453
Trichomonas vaginalis	cyclins, putative	0.0075	0.1442	0.5809
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.001	0.0047	0.0115
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0115	0.0115
Schistosoma mansoni	nuclear receptor	0.0009	0.0024	0.0059
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.004	0.0679	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0567	0.0567
Echinococcus multilocularis	cyclins	0.0064	0.1204	0.2288
Onchocerca volvulus	Cyclin L homolog	0.0016	0.0163	0.014
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0163	0.0658
Trypanosoma cruzi	mitotic cyclin, putative	0.0016	0.0163	0.0205
Echinococcus granulosus	cyclins	0.0064	0.1204	0.2288
Echinococcus granulosus	Cyclin L1	0.0016	0.0163	0.0311
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0115	0.0115
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0015	0.0162	0.0309
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0016	0.0163	0.0163
Brugia malayi	nuclear receptor NHR-67	0.0009	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0024	0.0024
Loa Loa (eye worm)	DR-78	0.0009	0.0024	0.0024
Echinococcus multilocularis	survival motor neuron protein 1	0.0255	0.5261	1
Schistosoma mansoni	survival motor neuron protein	0.0052	0.094	0.2309
Schistosoma mansoni	zinc finger protein	0.0009	0.0024	0.0059
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0009	0.0024	0.0046
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0019	0.0238	0.0238
Leishmania major	cyclin	0.0124	0.2483	1
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.001	0.0047	0.0047
Brugia malayi	orphan nuclear receptor NR2E1	0.0009	0.0024	0.0024
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0009	0.0024	0.0059
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0019	0.0238	0.0238
Echinococcus multilocularis	FTZ F1 alpha	0.0019	0.0238	0.0453
Schistosoma mansoni	nuclear receptor	0.0009	0.0024	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0165	0.0165
Echinococcus multilocularis	cyclins	0.0064	0.1204	0.2288
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0024	0.0024
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0009	0.0024	0.0046
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.1002	0.4037
Schistosoma mansoni	nuclear receptor nhr-48	0.0009	0.0024	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0354	0.0354
Echinococcus granulosus	cyclins	0.0064	0.1204	0.2288
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0079	0.1523	0.2895
Schistosoma mansoni	g1/s-specific cyclin C	0.0016	0.0163	0.0402
Echinococcus granulosus	cyclin B	0.0124	0.2483	0.4719
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0019	0.0238	0.0453
Trichomonas vaginalis	cyclin B, putative	0.0016	0.0163	0.0658
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0009	0.0024	0.0024
Schistosoma mansoni	cyclin B3	0.0199	0.4069	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0055	0.1002	0.3747
Trichomonas vaginalis	cyclin A, putative	0.0016	0.0163	0.0658
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0019	0.0238	0.0238
Trichomonas vaginalis	cyclin B, putative	0.0016	0.0163	0.0658
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0024	0.0024
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0115	0.0115
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0009	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0024	0.0024
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.001	0.0047	0.0047
Giardia lamblia	G2/mitotic-specific cyclin B	0.0124	0.2483	1
Schistosoma mansoni	hypothetical protein	0.0011	0.0067	0.0164
Onchocerca volvulus	Protein ultraspiracle homolog	0.0019	0.0238	0.0215
Brugia malayi	ecdysteroid receptor	0.0019	0.0238	0.0238
Trichomonas vaginalis	cyclins, putative	0.0016	0.0163	0.0658
Schistosoma mansoni	serine/threonine protein kinase	0.0055	0.1002	0.2463
Plasmodium vivax	ataxin-2 like protein, putative	0.0024	0.0354	1
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0199	0.4069	0.7735
Brugia malayi	nuclear hormone receptor family member odr-7	0.0009	0.0024	0.0024
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0019	0.0238	0.0238
Schistosoma mansoni	RAR-like nuclear receptor	0.0019	0.0238	0.0586
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0354	0.1836
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.001	0.0047	0.0089
Echinococcus granulosus	cyclin	0.0016	0.0163	0.0311
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0019	0.0238	0.0238
Schistosoma mansoni	nuclear hormone receptor	0.0019	0.0238	0.0586
Loa Loa (eye worm)	cyclin domain-containing protein	0.0016	0.0163	0.0163
Onchocerca volvulus		0.0019	0.0238	0.0215
Leishmania major	mitotic cyclin, putative	0.0016	0.0163	0.0205
Schistosoma mansoni	thyroid hormone receptor	0.0019	0.0238	0.0586
Loa Loa (eye worm)	nuclear hormone receptor	0.0009	0.0024	0.0024
Brugia malayi	MAP kinase sur-1	0.0055	0.1002	0.1002
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0016	0.0163	0.0402
Echinococcus granulosus	death domain containing protein	0.0015	0.0162	0.0309
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0037	0.0623	0.2511
Schistosoma mansoni	voltage-gated potassium channel	0.0012	0.0078	0.0191
Onchocerca volvulus	Bile acid receptor homolog	0.0019	0.0238	0.0215
Trypanosoma brucei	cyclin dependent kinase-binding protein, putative	0.0016	0.0163	0.0205
Trichomonas vaginalis	cyclin A, putative	0.0124	0.2483	1
Brugia malayi	conserved hypotetical protein	0.0009	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0238	0.0238
Brugia malayi	nuclear hormone receptor	0.0019	0.0238	0.0238
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0019	0.0238	0.0238
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0019	0.0238	0.0586
Trichomonas vaginalis	cyclin D, putative	0.0064	0.1204	0.4849
Plasmodium falciparum	cyclin	0.0064	0.1204	1
Echinococcus granulosus	Ankyrin	0.0016	0.0165	0.0314
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0055	0.1002	0.3747
Loa Loa (eye worm)	hypothetical protein	0.001	0.0047	0.0047
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0067	0.0126
Loa Loa (eye worm)	hypothetical protein	0.001	0.0047	0.0047
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0354	0.1012
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0019	0.0238	0.0453
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0055	0.1002	0.3747
Brugia malayi	hypothetical protein	0.0255	0.5261	0.5261
Brugia malayi	hypothetical protein	0.001	0.0047	0.0047
Trypanosoma brucei	cyclin 3	0.0016	0.0163	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0477	1	1
Echinococcus granulosus	FTZ F1 alpha	0.0019	0.0238	0.0453
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0047	0.0047
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.004	0.0679	0.0679
Trypanosoma cruzi	cyclin 6, putative	0.0124	0.2483	1
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0013	0.0115	0.5
Leishmania major	hypothetical protein, conserved	0.0024	0.0354	0.1012
Brugia malayi	steroid hormone receptor	0.0019	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0124	0.2483	0.2483
Trichomonas vaginalis	cyclin B3, putative	0.0064	0.1204	0.4849
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0055	0.1002	0.3747
Trichomonas vaginalis	cyclins, putative	0.0124	0.2483	1
Brugia malayi	cyclin fold protein 1 variant b	0.0016	0.0163	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0238	0.0238
Echinococcus multilocularis	cyclin A3 4	0.0016	0.0163	0.0311
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0124	0.2483	0.2483
Loa Loa (eye worm)	cyclin C	0.0016	0.0163	0.0163
Entamoeba histolytica	cyclin, putative	0.0124	0.2483	1
Echinococcus granulosus	cyclin y	0.0016	0.0163	0.0311
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0019	0.0238	0.0453
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0019	0.0238	0.0238
Schistosoma mansoni	Cyclin fold protein	0.0016	0.0163	0.0402
Giardia lamblia	Hypothetical protein	0.0064	0.1204	0.4486
Loa Loa (eye worm)	hypothetical protein	0.0124	0.2483	0.2483
Giardia lamblia	Kinase, CMGC MAPK	0.0055	0.1002	0.3617
Trichomonas vaginalis	cyclin B3, putative	0.0016	0.0163	0.0658
Loa Loa (eye worm)	hypothetical protein	0.001	0.0047	0.0047
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0009	0.0024	0.0046
Echinococcus granulosus	cyclin b3	0.0064	0.1204	0.2288
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0019	0.0238	0.0238
Brugia malayi	Uncoordinated protein 44	0.0015	0.0162	0.0162
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0016	0.0163	0.0163
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0019	0.0238	0.0215
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0124	0.2483	0.2483
Echinococcus multilocularis	cyclins	0.0064	0.1204	0.2288
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0067	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0163	0.0163
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0354	0.1836
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0019	0.0238	0.0586
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0163	0.0658
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0024	0.0024
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0019	0.0238	0.0453
Brugia malayi	hypothetical protein	0.0016	0.0163	0.0163
Schistosoma mansoni	nuclear hormone receptor	0.0009	0.0024	0.0059
Brugia malayi	Nuclear hormone receptor E75	0.0009	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0024	0.0024
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0055	0.1002	0.1905
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0238	0.0238
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0019	0.0238	0.0453
Echinococcus multilocularis	cdk5 and abl1 enzyme substrate 1	0.0016	0.0163	0.0311
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0009	0.0024	0.0046
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0012	0.0078	0.0148
Trichomonas vaginalis	cyclin B, putative	0.0124	0.2483	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0019	0.0238	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0024	0.0024
Loa Loa (eye worm)	cyclin domain-containing protein	0.0016	0.0163	0.0163
Echinococcus granulosus	voltage gated potassium channel	0.0012	0.0078	0.0148
Echinococcus granulosus	G1:S specific cyclin D1	0.0016	0.0163	0.0311
Echinococcus granulosus	nuclear receptor nhr 48	0.0009	0.0024	0.0046
Echinococcus multilocularis	netrin receptor unc 5	0.0015	0.0162	0.0309
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0016	0.0163	0.0163
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0009	0.0024	0.0059
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0124	0.2483	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 12 uM	Inhibition of cyclin-dependent kinase 2-cyclin A3 (CDK2)	ChEMBL.	15239650
IC50 (binding)	= 12 uM	Inhibition of cyclin-dependent kinase 2-cyclin A3 (CDK2)	ChEMBL.	15239650
IC50 (binding)	= 13 uM	Inhibitory activity against cyclin-dependent kinase 1-cyclin B.	ChEMBL.	15239650
IC50 (binding)	= 13 uM	Inhibitory activity against cyclin-dependent kinase 1-cyclin B.	ChEMBL.	15239650

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 5329553

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 213747