TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 411.206 | Formula: C25H25N5O
H donors: 1 H acceptors: 3 LogP: 4.28 Rotable bonds: 5
Rule of 5 violations (Lipinski): 0
SMILES: COc1ccc(cc1)c1cnc2c(n1)c(cnc2)Nc1ccc(cc1)N1CCCCC1
InChi: InChI=1S/C25H25N5O/c1-31-21-11-5-18(6-12-21)22-17-27-23-15-26-16-24(25(23)29-22)28-19-7-9-20(10-8-19)30-13-3-2-4-14-30/h5-12,15-17,28H,2-4,13-14H2,1H3
InChiKey: RTYGBULZXQMRLX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Bibliographic reference
Homo sapiens	kinase insert domain receptor	No references
Homo sapiens	neurotrophic tyrosine kinase, receptor, type 1	No references
Homo sapiens	Pim-1 proto-oncogene, serine/threonine kinase	No references
Homo sapiens	mitogen-activated protein kinase 1	No references
Homo sapiens	YES proto-oncogene 1, Src family tyrosine kinase	No references
Homo sapiens	homeodomain interacting protein kinase 1	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Leishmania donovani	mitogen-activated protein kinase 4	Get druggable targets OG5_126781	All targets in OG5_126781
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320
Schistosoma japonicum	ko:K08826 homeodomain interacting protein kinase, putative	Get druggable targets OG5_129272	All targets in OG5_129272
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_134863	All targets in OG5_134863
Brugia malayi	Serine/threonine-protein kinase Pim-3	Get druggable targets OG5_134863	All targets in OG5_134863
Brugia malayi	Homeodomain interacting protein kinase protein 1	Get druggable targets OG5_129272	All targets in OG5_129272
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Brugia malayi	MAP kinase sur-1	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Leishmania braziliensis	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Candida albicans	hypothetical protein	Get druggable targets OG5_129272	All targets in OG5_129272
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129272	All targets in OG5_129272
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania mexicana	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania infantum	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Cryptosporidium hominis	MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Echinococcus granulosus	homeodomain interacting protein kinase 3	Get druggable targets OG5_129272	All targets in OG5_129272
Echinococcus multilocularis	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	expressed protein	Get druggable targets OG5_129272	All targets in OG5_129272
Giardia lamblia	Kinase, CMGC MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320
Trypanosoma congolense	tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	CAMK/PIM protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Trypanosoma brucei	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320
Trypanosoma brucei gambiense	protein kinase, putative,tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Onchocerca volvulus	Serine\/threonine protein kinase homolog	Get druggable targets OG5_134863	All targets in OG5_134863
Echinococcus multilocularis	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	CAMK/PIM protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Candida albicans	hypothetical protein	Get druggable targets OG5_129272	All targets in OG5_129272
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	CMGC/DYRK/HIPK protein kinase	Get druggable targets OG5_129272	All targets in OG5_129272
Candida albicans	similar to C terminus of S. cerevisiae YAK1 (YJL141C) serine-threonine protein kinase	Get druggable targets OG5_129272	All targets in OG5_129272
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Cryptosporidium parvum	MAPK, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Candida albicans	similar to C terminus of S. cerevisiae YAK1 (YJL141C) serine-threonine protein kinase	Get druggable targets OG5_129272	All targets in OG5_129272
Leishmania infantum	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_129272	All targets in OG5_129272
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Echinococcus multilocularis	homeodomain interacting protein kinase 3	Get druggable targets OG5_129272	All targets in OG5_129272
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative	Get druggable targets OG5_134863	All targets in OG5_134863
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase implicated in PKC1-controlled signalling pathway	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K04371 extracellular signal-regulated kinase 1/2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania braziliensis	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania donovani	mitogen activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania mexicana	mitogen-activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei gambiense	mitogen-activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 1	360 aa	361 aa	33.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	serine/threonine protein kinase	0.0008	0.0079	0.0074
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0043	0.1854	0.1854
Trichomonas vaginalis	CMGC family protein kinase	0.0063	0.2825	0.5
Echinococcus granulosus	mitogen activated protein kinase 3	0.0063	0.2825	0.2825
Schistosoma mansoni	nck2/grb4	0.0009	0.0127	0.0123
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0007	0.0005	0.0005
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0194	0.9405	0.9405
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0048	0.2077	0.2077
Echinococcus granulosus	tyrosine protein kinase Srms	0.0008	0.0084	0.0084
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0008	0.0088	0.0088
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.0084	0.0084
Echinococcus multilocularis	homeodomain interacting protein kinase 3	0.0205	1	1
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0194	0.9405	1
Echinococcus multilocularis	tyrosine kinase	0.0008	0.0084	0.0084
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0011	0.0241	0.0241
Schistosoma mansoni	serine/threonine protein kinase	0.0194	0.9405	0.9405
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0007	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0241	0.0241
Echinococcus granulosus	neuroglian	0.0007	0.0005	0.0005
Echinococcus multilocularis	roundabout 2	0.0007	0.0005	0.0005
Onchocerca volvulus		0.0008	0.0084	0.0085
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0048	0.2077	0.2077
Onchocerca volvulus		0.0167	0.8052	0.8561
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0005	0.0005
Schistosoma mansoni	tyrosine kinase	0.0048	0.2077	0.2073
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0008	0.0084	0.0084
Echinococcus granulosus	roundabout 2	0.0007	0.0005	0.0005
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0039	0.1625	0.1625
Schistosoma mansoni	tyrosine kinase	0.001	0.0184	0.018
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0084	0.0084
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0007	0.0005	0.0005
Loa Loa (eye worm)	TK protein kinase	0.0043	0.1854	0.1854
Echinococcus multilocularis	Immunoglobulin	0.0011	0.0241	0.0241
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0008	0.0084	0.0084
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0007	0.0005	0.0005
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0048	0.2077	0.2077
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0015	0.0425	0.0425
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0048	0.2077	0.2077
Entamoeba histolytica	protein kinase, putative	0.0039	0.1625	0.1554
Brugia malayi	hypothetical protein	0.0011	0.0241	0.0241
Onchocerca volvulus		0.0008	0.0084	0.0085
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0063	0.2825	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0007	0.0005	0.0005
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0194	0.9405	0.9405
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0569	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0241	0.0241
Brugia malayi	SRC-1	0.0048	0.2077	0.2077
Echinococcus multilocularis	neuroglian	0.0007	0.0005	0.0005
Echinococcus multilocularis	tyrosine protein kinase shark	0.0008	0.0084	0.0084
Echinococcus granulosus	growth factor receptor bound protein 2	0.0009	0.0127	0.0127
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.0084	0.0084
Echinococcus multilocularis	peroxidasin	0.0007	0.0012	0.0012
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0007	0.0005	0.0005
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0048	0.2077	0.2077
Giardia lamblia	Kinase, CMGC MAPK	0.0063	0.2825	0.5
Schistosoma mansoni	nephrin	0.0014	0.0385	0.0381
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0007	0.0005	0.0005
Echinococcus granulosus	lachesin	0.0007	0.0005	0.0005
Echinococcus multilocularis	hemicentin 1	0.0007	0.0005	0.0005
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0194	0.9405	0.9405
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0013	0.0307	0.0307
Echinococcus granulosus	contactin	0.0007	0.0005	0.0005
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0007	0.0005	0.0005
Echinococcus granulosus	tyrosine protein kinase Src42A	0.004	0.1674	0.1674
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0007	0.0005	0.0005
Echinococcus multilocularis	Immunoglobulin	0.0011	0.0241	0.0241
Schistosoma mansoni	cell adhesion molecule	0.0015	0.0425	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0127	0.0127
Echinococcus multilocularis	roundabout 2	0.0018	0.0569	0.0569
Brugia malayi	hypothetical protein	0.0008	0.0084	0.0084
Schistosoma mansoni	vesicular amine transporter	0.0011	0.0241	0.0236
Brugia malayi	SH2 domain containing protein	0.0008	0.0084	0.0084
Brugia malayi	SH2 domain containing protein	0.0008	0.0084	0.0084
Brugia malayi	Protein kinase domain containing protein	0.0194	0.9405	0.9405
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0048	0.2077	0.2077
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0048	0.2077	0.2077
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0009	0.0127	0.0127
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0084	0.0084
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0013	0.0307	0.0303
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0194	0.9405	0.9405
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0063	0.2825	0.5
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0009	0.0127	0.0127
Brugia malayi	Variant SH3 domain containing protein	0.0009	0.0127	0.0127
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0084	0.0084
Onchocerca volvulus	Tyrosine kinase homolog	0.0173	0.8376	0.8905
Brugia malayi	MAP kinase sur-1	0.0063	0.2825	0.2825
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.0084	0.0084
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0043	0.1854	0.1854
Echinococcus granulosus	tyrosine protein kinase shark	0.0008	0.0084	0.0084
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0194	0.9405	0.9405
Schistosoma mansoni	tyrosine kinase	0.0008	0.0084	0.008
Onchocerca volvulus		0.0008	0.0084	0.0085
Trichomonas vaginalis	CMGC family protein kinase	0.0063	0.2825	0.5
Trichomonas vaginalis	CMGC family protein kinase	0.0063	0.2825	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0241	0.0241
Echinococcus granulosus	tyrosine protein kinase Blk	0.0043	0.1854	0.1854
Echinococcus granulosus	tyrosine protein kinase otk	0.0007	0.0005	0.0005
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0013	0.0307	0.0307
Echinococcus granulosus	neuroglian	0.0014	0.0385	0.0385
Brugia malayi	Fibronectin type III domain containing protein	0.0011	0.0241	0.0241
Brugia malayi	Prion-like-	0.0007	0.0005	0.0005
Echinococcus granulosus	tyrosine kinase	0.0043	0.1854	0.1854
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0048	0.2077	0.2077
Brugia malayi	Sex muscle abnormal protein 5	0.0009	0.0127	0.0127
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0007	0.0005	0.0005
Echinococcus multilocularis	tyrosine protein kinase otk	0.0007	0.0005	0.0005
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0185	0.898	0.898
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0063	0.2825	0.2825
Schistosoma mansoni	serine/threonine protein kinase	0.0205	1	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0005	0.0005
Echinococcus multilocularis	neuroglian	0.0014	0.0385	0.0385
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0008	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0005	0.0005
Echinococcus granulosus	homeodomain interacting protein kinase 3	0.0205	1	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0569	0.0569
Schistosoma mansoni	tyrosine kinase	0.0008	0.0084	0.008
Entamoeba histolytica	protein kinase domain containing protein	0.0205	1	1
Loa Loa (eye worm)	CMGC/DYRK/HIPK protein kinase	0.0205	1	1
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0084	0.0084
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0011	0.0241	0.0236
Trichomonas vaginalis	CMGC family protein kinase	0.0063	0.2825	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0084	0.0084
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0063	0.2825	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0008	0.0084	0.0084
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.0084	0.0084
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0063	0.2825	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0048	0.2077	0.2077
Echinococcus granulosus	defective proboscis extension response	0.0011	0.0241	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0005	0.0005
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0009	0.0127	0.0127
Echinococcus granulosus	hemicentin 1	0.0007	0.0005	0.0005
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0043	0.1854	0.1854
Echinococcus granulosus	roundabout 2	0.0007	0.0005	0.0005
Onchocerca volvulus		0.0008	0.0084	0.0085
Schistosoma mansoni	tyrosine kinase	0.0013	0.0307	0.0303
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0048	0.2077	0.2077
Schistosoma mansoni	adapter molecule crk	0.0009	0.0127	0.0123
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0063	0.2825	0.2825
Onchocerca volvulus		0.0008	0.0084	0.0085
Echinococcus granulosus	c src tyrosine kinase	0.0013	0.0307	0.0307
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.0084	0.0084
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.0084	0.0084
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0007	0.0005	0.0005
Schistosoma mansoni	tyrosine kinase	0.0013	0.0307	0.0303
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0425	0.0425
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0048	0.2077	0.2077
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0241	0.0241
Echinococcus multilocularis	roundabout 2	0.0007	0.0005	0.0005
Trypanosoma brucei	protein kinase, putative	0.0063	0.2825	0.5
Echinococcus granulosus	tyrosine kinase	0.0008	0.0084	0.0084
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0063	0.2825	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.0084	0.0084
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0007	0.0005	0.0005
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0063	0.2825	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0009	0.0127	0.0123
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.004	0.1674	0.1674
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0063	0.2825	0.5
Echinococcus multilocularis	lachesin	0.0007	0.0005	0.0005
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0007	0.0005	0.0005
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0009	0.0127	0.0123
Schistosoma mansoni	growth factor receptor-bound protein	0.0009	0.0127	0.0123
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0011	0.0241	0.0241
Echinococcus multilocularis	mitogen activated protein kinase	0.0063	0.2825	0.2825
Echinococcus granulosus	twitchin	0.0016	0.0469	0.0469
Onchocerca volvulus		0.0008	0.0084	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0241	0.0241
Echinococcus granulosus	tyrosine protein kinase HCK	0.0039	0.1625	0.1625
Loa Loa (eye worm)	SRC-1	0.0048	0.2077	0.2077
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0007	0.0005	0.0005
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0007	0.0005	0.0005
Brugia malayi	protein-tyrosine kinase	0.0043	0.1854	0.1854
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0011	0.0241	0.0236
Echinococcus granulosus	roundabout 2	0.0018	0.0569	0.0569
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0008	0.0084	0.0084
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0007	0.0005	0.0005
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0013	0.0307	0.0307
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0048	0.2077	0.2077
Echinococcus granulosus	peroxidasin	0.0007	0.0012	0.0012
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0049	0.216	0.216
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0048	0.2077	0.2077
Brugia malayi	Variant SH3 domain containing protein	0.0009	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0005	0.0005
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0063	0.2825	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0048	0.2077	0.2077
Echinococcus multilocularis	c src tyrosine kinase	0.0013	0.0307	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0005	0.0005
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.0084	0.0084
Echinococcus multilocularis	hemicentin 1	0.0007	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0005	0.0005
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.0084	0.0084
Echinococcus granulosus	Immunoglobulin	0.0011	0.0241	0.0241
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0043	0.1854	0.1854
Echinococcus granulosus	mitogen activated protein kinase	0.0063	0.2825	0.2825
Loa Loa (eye worm)	TK protein kinase	0.0039	0.1625	0.1625
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0048	0.2077	0.2077
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0185	0.898	0.898
Brugia malayi	Tyrosine-protein kinase abl-1	0.0013	0.0307	0.0307
Schistosoma mansoni	serine/threonine protein kinase	0.0063	0.2825	0.2821
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0007	0.0005	0.0005
Echinococcus granulosus	NCK adaptor protein	0.0009	0.0127	0.0127
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0084	0.0084
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0007	0.0005	0.0005
Brugia malayi	Peroxidasin	0.0007	0.0012	0.0012
Echinococcus multilocularis	NCK adaptor protein	0.0009	0.0127	0.0127
Schistosoma mansoni	tyrosine kinase	0.0048	0.2077	0.2073
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0048	0.2077	0.2077

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.05 uM	Inhibition of N-terminal His6-tagged human recombinant KDR (790 to end residues) expressed in baculovirus infected insect Sf21 cells after 1 hr by Alphascreen assay	ChEMBL.	No reference
IC50 (binding)	= 2.83 uM	Inhibition of N-terminal GST-tagged recombinant human full length Pim-1 expressed in Escherichia coli after 1 hr by Alphascreen assay	ChEMBL.	No reference
IC50 (binding)	= 3.13 uM	Inhibition of recombinant ERK2 (unknown origin) after 1 hr by Alphascreen assay	ChEMBL.	No reference
IC50 (binding)	= 3.21 uM	Inhibition of N-terminal His6-tagged recombinant human HIPK1 (158 to 555 residues) after 1 hr by Alphascreen assay	ChEMBL.	No reference
IC50 (binding)	= 3.72 uM	Inhibition of N-terminal His6-tagged human recombinant TrkA (440 to end residues) expressed in baculovirus infected insect Sf21 cells after 1 hr by Alphascreen assay	ChEMBL.	No reference
IC50 (binding)	= 5.34 uM	Inhibition of N-terminal His6-tagged human recombinant Yes expressed in baculovirus infected insect Sf21 cells after 1 hr by Alphascreen assay	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3780971

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2140577