Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0128 | 0.0699 | 0.5 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0128 | 0.0699 | 0.0699 |
Leishmania major | carnitine/choline acetyltransferase, putative | 0.0128 | 0.0699 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0985 | 0.0985 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0128 | 0.0699 | 0.5 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0128 | 0.0699 | 0.0699 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0128 | 0.0699 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0985 | 0.0985 |
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | 0.0128 | 0.0699 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0128 | 0.0699 | 0.5 |
Onchocerca volvulus | 0.0128 | 0.0699 | 1 | |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0128 | 0.0699 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0128 | 0.0699 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0073 | 0 | 0.5 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.015 | 0.0985 | 0.0985 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0128 | 0.0699 | 0.0699 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0128 | 0.0699 | 0.0699 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0699 | 0.0699 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0128 | 0.0699 | 0.0699 |
Echinococcus granulosus | choline O acetyltransferase | 0.0854 | 1 | 1 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0128 | 0.0699 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.015 | 0.0985 | 0.0985 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0128 | 0.0699 | 0.5 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0128 | 0.0699 | 0.0699 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0128 | 0.0699 | 0.0699 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0128 | 0.0699 | 0.5 |
Onchocerca volvulus | 0.0128 | 0.0699 | 1 | |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0128 | 0.0699 | 0.5 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0854 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0128 | 0.0699 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.0854 | 1 | 1 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0128 | 0.0699 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0128 | 0.0699 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0128 | 0.0699 | 0.5 |
Onchocerca volvulus | 0.0128 | 0.0699 | 1 | |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0128 | 0.0699 | 0.5 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0128 | 0.0699 | 0.5 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0128 | 0.0699 | 0.0699 |
Onchocerca volvulus | 0.0128 | 0.0699 | 1 | |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.015 | 0.0985 | 0.0985 |
Loa Loa (eye worm) | hypothetical protein | 0.0854 | 1 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0854 | 1 | 1 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0854 | 1 | 1 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0128 | 0.0699 | 0.5 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0128 | 0.0699 | 0.0699 |
Echinococcus multilocularis | serotonin receptor | 0.015 | 0.0985 | 0.0985 |
Trypanosoma cruzi | carnitine O-acetyltransferase, putative | 0.0128 | 0.0699 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0128 | 0.0699 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.0128 | 0.0699 | 0.0699 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Emax (functional) | = 6.32 % | Maximal stimulation of expressed human 5-hydroxytryptamine 1A receptor assayed by [35S]-GTP-gammaS, binding | ChEMBL. | 14592479 |
Emax (functional) | = 6.32 % | Maximal stimulation of expressed human 5-hydroxytryptamine 1A receptor assayed by [35S]-GTP-gammaS, binding | ChEMBL. | 14592479 |
Ki (binding) | = 0.62 nM | Affinity at the 5-HT reuptake site labeled with [3H]-paroxetine using rat frontal cortex membranes | ChEMBL. | 14592479 |
Ki (binding) | = 0.62 nM | Affinity at the 5-HT reuptake site labeled with [3H]-paroxetine using rat frontal cortex membranes | ChEMBL. | 14592479 |
Ki (binding) | = 10.52 nM | Binding affinity towards 5-hydroxytryptamine 1A receptor in human using [3H]-8-OH-DPAT as radioligand | ChEMBL. | 14592479 |
Ki (binding) | = 10.52 nM | Binding affinity towards 5-hydroxytryptamine 1A receptor in human using [3H]-8-OH-DPAT as radioligand | ChEMBL. | 14592479 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.