Detailed information for compound 231872

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 257.261 | Formula: C13H16NNaO3
  • H donors: 1 H acceptors: 3 LogP: 3.16 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CC(C(=O)[O-])NC(=O)c1ccccc1)C.[Na+]
  • InChi: 1S/C13H17NO3.Na/c1-9(2)8-11(13(16)17)14-12(15)10-6-4-3-5-7-10;/h3-7,9,11H,8H2,1-2H3,(H,14,15)(H,16,17);/q;+1/p-1
  • InChiKey: QJGKTECQCGJVTA-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0097 0.0092
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0276 0.2665
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0276 0.2665
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0097 0.0092
Onchocerca volvulus 0.0011 0.0097 0.0123
Schistosoma mansoni hypothetical protein 0.0006 0.0021 0.0016
Loa Loa (eye worm) hypothetical protein 0.05 0.7477 1
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0097 0.0092
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0033 0.0028
Onchocerca volvulus 0.0011 0.0097 0.0123
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0069 0.0064
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0024 0.0056
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0065 0.0922
Loa Loa (eye worm) hypothetical protein 0.05 0.7477 1
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0502 0.5276
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0006 0.0021 0.0022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0199 0.0261
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0011 0.0097 0.0092
Mycobacterium tuberculosis Probable sulfatase 0.0009 0.0065 0.0124
Mycobacterium tuberculosis Conserved protein 0.0038 0.0502 0.1347
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0065 0.0922
Brugia malayi hypothetical protein 0.0011 0.0097 0.0123
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0017 0.0184 0.024
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0065 0.0922
Brugia malayi G-protein coupled receptor 0.0011 0.0097 0.0123
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0097 0.0092
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0276 0.2665
Schistosoma mansoni sulfide quinone reductase 0.0006 0.0021 0.0016
Echinococcus granulosus 7TM GPCR rhodopsin 0.0011 0.0097 0.0092
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0089 0.0085
Loa Loa (eye worm) hypothetical protein 0.05 0.7477 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0069 0.0086
Brugia malayi beta-lactamase family protein 0.0038 0.0502 0.0665
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0097 0.0092
Loa Loa (eye worm) TYRA-2 protein 0.0011 0.0097 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0089 0.0114
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0097 0.0092
Onchocerca volvulus 0.0011 0.0097 0.0123
Schistosoma mansoni neuropeptide receptor 0.0011 0.0097 0.0092
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0011 0.0097 0.0123
Mycobacterium ulcerans arylsulfatase AtsD 0.0009 0.0065 0.0922
Brugia malayi neuropeptide F receptor 0.0011 0.0097 0.0123
Echinococcus granulosus alpha 1A adrenergic receptor 0.0011 0.0097 0.0092
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0014 0.0009
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0011 0.0097 0.0092
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.011 0.093
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.0979 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0089 0.0085
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0012
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0011 0.0097 0.0123
Echinococcus granulosus cpg binding protein 0.0029 0.0372 0.0367
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0009 0.0065 0.0081
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0011 0.0097 0.0123
Echinococcus granulosus serotonin receptor 0.0011 0.0097 0.0092
Brugia malayi beta-lactamase 0.0038 0.0502 0.0665
Brugia malayi hypothetical protein 0.0011 0.0097 0.0123
Onchocerca volvulus 0.0011 0.0097 0.0123
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.5898 0.5896
Brugia malayi follicle stimulating hormone receptor 0.0253 0.3757 0.5022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0097 0.0092
Onchocerca volvulus 0.0028 0.0348 0.0459
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0097 0.0092
Schistosoma mansoni glutamate synthase 0.0006 0.0021 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0089 0.0114
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0089 0.0085
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0089 0.0114
Schistosoma mansoni peroxidasin 0.05 0.7477 0.7476
Brugia malayi ORL1-like opioid receptor 0.0011 0.0097 0.0123
Schistosoma mansoni hypothetical protein 0.0133 0.1932 0.1928
Brugia malayi hypothetical protein 0.0011 0.0097 0.0123
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0069 0.0738
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0502 1
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0006 0.0021 0.0016
Loa Loa (eye worm) glutathione reductase 0.0066 0.0932 0.1241
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0023 0.0276 0.2665
Echinococcus granulosus allatostatin A receptor 0.0011 0.0097 0.0092
Schistosoma mansoni hypothetical protein 0.0011 0.0097 0.0092
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Toxoplasma gondii NADPH-glutathione reductase 0.0023 0.0276 0.2964
Brugia malayi hypothetical protein 0.0011 0.0097 0.0123
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0268 0.0264
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0023 0.0276 0.0272
Brugia malayi hypothetical protein 0.0011 0.0097 0.0123
Loa Loa (eye worm) hypothetical protein 0.0011 0.0089 0.0114
Schistosoma mansoni growth hormone secretagogue receptor 0.0011 0.0097 0.0092
Schistosoma mansoni opsin-like receptor 0.0011 0.0097 0.0092
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0089 0.0114
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0089 0.0085
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0089 0.0114
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0089 0.0085
Mycobacterium ulcerans arylsulfatase AtsD 0.0009 0.0065 0.0922
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0097 0.0092
Loa Loa (eye worm) hypothetical protein 0.0009 0.0065 0.0081
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0006 0.0021 0.0224
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0097 0.0092
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0089 0.0114
Schistosoma mansoni amine GPCR 0.0011 0.0097 0.0092
Schistosoma mansoni amine GPCR 0.0011 0.0097 0.0092
Onchocerca volvulus 0.0011 0.0097 0.0123
Onchocerca volvulus 0.0011 0.0097 0.0123
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Onchocerca volvulus 0.0011 0.0097 0.0123
Brugia malayi Thioredoxin reductase 0.0066 0.0932 0.1241
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0089 0.0114
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0069 0.0738
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Brugia malayi hypothetical protein 0.0315 0.4687 0.6266
Brugia malayi AKH receptor 0.0011 0.0097 0.0123
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0024 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0024 0.0056
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0979 0.0975
Onchocerca volvulus Protein cereblon homolog 0.0315 0.4687 0.6266
Brugia malayi Animal haem peroxidase family protein 0.05 0.7477 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0011 0.0097 0.0092
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0502 1
Echinococcus granulosus glutamate synthase 0.0006 0.0021 0.0016
Brugia malayi hypothetical protein 0.0011 0.0097 0.0123
Echinococcus multilocularis orexin receptor type 2 0.0011 0.0097 0.0092
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0502 0.1347
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0097 0.0123
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0502 0.0665
Brugia malayi Animal haem peroxidase family protein 0.05 0.7477 1
Mycobacterium ulcerans arylsulfatase AtsB 0.0009 0.0065 0.0922
Loa Loa (eye worm) beta-lactamase 0.0038 0.0502 0.0665
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0502 0.0497
Plasmodium falciparum glutathione reductase 0.0023 0.0276 0.2803
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Schistosoma mansoni adenoreceptor 0.0011 0.0097 0.0092
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0502 0.1347
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0014 0.0009
Echinococcus granulosus sex peptide receptor 0.0011 0.0097 0.0092
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0058 0.0054
Echinococcus multilocularis neuropeptide FF receptor 2 0.0011 0.0097 0.0092
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0276 0.2665
Brugia malayi sulfakinin receptor protein 0.0011 0.0097 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0065 0.0922
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0276 0.2665
Brugia malayi nuclear receptor RXR 0.0006 0.0014 0.0012
Brugia malayi Peroxidasin 0.05 0.7477 1
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0006 0.0021 0.0016
Schistosoma mansoni alpha-1 adrenergic receptor 0.0011 0.0097 0.0092
Echinococcus multilocularis allatostatin A receptor 0.0011 0.0097 0.0092
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0006 0.0021 0.0016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0024 0.0056
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0011 0.0097 0.0092
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Schistosoma mansoni hypothetical protein 0.0011 0.0097 0.0092
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0097 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0024 0.0056
Mycobacterium ulcerans lipase LipD 0.0038 0.0502 1
Schistosoma mansoni myosin xvIII 0.0011 0.0097 0.0092
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0017 0.0184 0.024
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0097 0.0123
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0089 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0065 0.0922
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0097 0.0092
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0006 0.0021 0.0016
Onchocerca volvulus Peroxidasin homolog 0.05 0.7477 1
Schistosoma mansoni amine GPCR 0.0011 0.0097 0.0092
Trichomonas vaginalis glutathione reductase, putative 0.0023 0.0276 0.5313
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0023 0.0276 0.2665
Schistosoma mansoni opsin-like receptor 0.0011 0.0097 0.0092
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0023 0.0276 0.0272
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0097 0.0092
Schistosoma mansoni hypothetical protein 0.0011 0.0097 0.0092
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0502 0.0497
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0065 0.0922
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0023 0.0276 0.5313
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0069 0.0064
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Schistosoma mansoni DNA helicase recq1 0.0009 0.0069 0.0064
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0012
Trypanosoma brucei trypanothione reductase 0.0066 0.0932 0.9507
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0065 0.0922
Echinococcus granulosus peroxidasin 0.05 0.7477 0.7476
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0024 0.0056
Echinococcus multilocularis sex peptide receptor 0.0011 0.0097 0.0092
Brugia malayi ecdysteroid receptor 0.0011 0.0089 0.0114
Onchocerca volvulus 0.0011 0.0097 0.0123
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0502 0.1347
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0097 0.0092
Echinococcus granulosus G protein coupled receptor 139 0.0011 0.0097 0.0092
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0069 0.0064
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0011 0.0097 0.0092
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0089 0.0114
Plasmodium falciparum thioredoxin reductase 0.0023 0.0276 0.2803
Schistosoma mansoni sulfide quinone reductase 0.0006 0.0021 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0089 0.0114
Schistosoma mansoni glutamate synthase 0.0006 0.0021 0.0016
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0097 0.0092
Mycobacterium ulcerans hypothetical protein 0.0038 0.0502 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0089 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0089 0.0114
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0502 0.5016
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0502 1
Brugia malayi Dopamine receptor protein 1 0.0011 0.0097 0.0123
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0502 0.1347
Loa Loa (eye worm) programmed cell death 8 0.0006 0.0021 0.0022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0268 0.5145
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0065 0.0922
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0023 0.0276 0.2803
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0065 0.0922
Entamoeba histolytica hypothetical protein, conserved 0.0315 0.4687 1
Schistosoma mansoni biogenic amine receptor 0.0011 0.0097 0.0092
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0502 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0023 0.0276 0.0716
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0502 0.5016
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0097 0.0092
Schistosoma mansoni histamine h1 receptor 0.0011 0.0097 0.0092
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0024 0.0056
Schistosoma mansoni DNA helicase recq5 0.0009 0.0069 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0065 0.0922
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.011 0.1854
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0023 0.0276 0.0716
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0023 0.0276 0.0364
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0024 0.0056
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Mycobacterium ulcerans arylsulfatase, AslA 0.0009 0.0065 0.0922
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0011 0.0097 0.0092
Schistosoma mansoni biogenic amine receptor 0.0011 0.0097 0.0092
Loa Loa (eye worm) hypothetical protein 0.05 0.7477 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0089 0.0085
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0011 0.0097 0.0123
Echinococcus granulosus 7tm_1 domain containing protein 0.0011 0.0097 0.0092
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.0009 0.0065 0.0922
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0268 0.0353
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0097 0.0092
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0089 0.0114
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0276 0.2665
Loa Loa (eye worm) hypothetical protein 0.0038 0.0502 0.0665
Schistosoma mansoni glutamate synthase 0.0006 0.0021 0.0016
Entamoeba histolytica disulphide oxidoreductase, putative 0.0006 0.0021 0.0044
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0011 0.0097 0.0092
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0022
Schistosoma mansoni neuropeptide f receptor 76f 0.0011 0.0097 0.0092
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0979 0.1304
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0502 1
Schistosoma mansoni amine GPCR 0.0011 0.0097 0.0092
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0723 0.7755
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.011 0.093
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0006 0.0021 0.0044
Loa Loa (eye worm) hypothetical protein 0.0011 0.0089 0.0114
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0033 0.0028
Brugia malayi G protein-coupled receptor F59B2.13 0.0011 0.0097 0.0123
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0023 0.0276 0.2803
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0276 0.2665
Onchocerca volvulus Peroxidasin homolog 0.05 0.7477 1
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0097 0.0092
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0097 0.0092
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0097 0.0092
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0276 0.2665
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0009 0.0065 0.0124
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0011 0.0097 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0089 0.0114
Brugia malayi neuropeptide F receptor 0.0011 0.0097 0.0123
Brugia malayi Serotonin receptor 0.0011 0.0097 0.0123
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0089 0.0085
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0009 0.0065 0.0124
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0089 0.0085
Brugia malayi putative neuropeptide receptor 0.0011 0.0097 0.0123
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0502 0.0497
Brugia malayi Sulfatase family protein 0.0009 0.0065 0.0081
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0006 0.0021 0.0224
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0011 0.0097 0.0123
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0006 0.0021 0.0224
Schistosoma mansoni thyroid hormone receptor 0.0143 0.2093 0.2089
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0023 0.0276 0.0716
Treponema pallidum NADH oxidase 0.0023 0.0276 1
Echinococcus granulosus geminin 0.0179 0.2625 0.2622
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0253 0.3757 0.5022
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0006 0.0021 0.0016
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0097 0.0092
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0006 0.0021 0.0022
Loa Loa (eye worm) hypothetical protein 0.0038 0.0502 0.0665
Loa Loa (eye worm) hypothetical protein 0.0038 0.0502 0.0665
Mycobacterium tuberculosis Conserved protein 0.0038 0.0502 0.1347
Brugia malayi hypothetical protein 0.0006 0.0014 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0097 0.0092
Onchocerca volvulus 0.0011 0.0097 0.0123
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0089 0.0085
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0011 0.0097 0.0092
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0069 0.0064
Toxoplasma gondii thioredoxin reductase 0.0066 0.0932 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0058 0.0054
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0011 0.0097 0.0123
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0006 0.0021 0.0016
Loa Loa (eye worm) hypothetical protein 0.05 0.7477 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0011 0.0097 0.0092
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0024 0.0056
Brugia malayi hypothetical protein 0.0006 0.0014 0.0012
Echinococcus multilocularis serotonin receptor 0.0011 0.0097 0.0092
Trypanosoma cruzi trypanothione reductase, putative 0.0023 0.0276 0.2665
Echinococcus granulosus neuropeptide s receptor 0.0011 0.0097 0.0092
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.0979 0.2089
Echinococcus granulosus orexin receptor type 2 0.0011 0.0097 0.0092
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0089 0.0085
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0006 0.0021 0.0224
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0006 0.0021 0.0044
Brugia malayi glutamate synthase 0.0006 0.0021 0.0022
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0268 0.5145
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0023 0.0276 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0227 0.2262
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0537 0.0532
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0089 0.0085
Brugia malayi Serotonin receptor 0.0011 0.0097 0.0123
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Brugia malayi hypothetical protein 0.0011 0.0097 0.0123
Brugia malayi hypothetical protein 0.0011 0.0097 0.0123
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0097 0.0092
Brugia malayi putative neuropeptide receptor NPR1 0.0011 0.0097 0.0123
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0089 0.0085
Brugia malayi hypothetical protein 0.0009 0.0065 0.0081
Echinococcus granulosus neuropeptide FF receptor 2 0.0011 0.0097 0.0092
Brugia malayi CXXC zinc finger family protein 0.0028 0.0348 0.0459
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0097 0.0092
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Onchocerca volvulus 0.05 0.7477 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0133 0.1932 0.1928
Echinococcus multilocularis neuropeptide receptor A26 0.0011 0.0097 0.0092
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Schistosoma mansoni hypothetical protein 0.0315 0.4687 0.4685
Loa Loa (eye worm) hypothetical protein 0.05 0.7477 1
Echinococcus multilocularis neuropeptide s receptor 0.0011 0.0097 0.0092
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0097 0.0092
Schistosoma mansoni hypothetical protein 0.0179 0.2625 0.2622
Echinococcus multilocularis peroxidasin 0.05 0.7477 0.7476
Onchocerca volvulus Peroxidase homolog 0.05 0.7477 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0197 0.0192
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0011 0.0097 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0024 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0065 0.0922
Echinococcus granulosus peptide allatostatin:somatostatin 0.0011 0.0097 0.0092
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0089 0.0114
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.0069 0.0526
Brugia malayi G protein-coupled receptor 0.0011 0.0097 0.0123
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0097 0.0092
Echinococcus granulosus transcription factor Dp 1 0.004 0.0537 0.0532
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0011 0.0097 0.0092
Loa Loa (eye worm) thioredoxin reductase 0.0066 0.0932 0.1241
Schistosoma mansoni coup transcription factor 0.0011 0.0089 0.0085
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0033 0.0028
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0089 0.0085
Loa Loa (eye worm) hypothetical protein 0.0011 0.0089 0.0114
Echinococcus multilocularis somatostatin receptor 0.0011 0.0097 0.0092
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0033 0.0028
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0097 0.0092
Onchocerca volvulus 0.0011 0.0097 0.0123
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0089 0.0085
Brugia malayi hypothetical protein 0.0011 0.0097 0.0123
Loa Loa (eye worm) hypothetical protein 0.0009 0.0065 0.0081
Echinococcus multilocularis geminin 0.0179 0.2625 0.2622
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0097 0.0092
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0097 0.0092
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0011 0.0097 0.0092
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0502 0.0665
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0089 0.0114
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0011 0.0097 0.0092
Loa Loa (eye worm) hypothetical protein 0.05 0.7477 1
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0502 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0089 0.0114
Brugia malayi hypothetical protein 0.0128 0.1866 0.2491
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0023 0.0276 0.5313
Brugia malayi Animal haem peroxidase family protein 0.05 0.7477 1
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0006 0.0021 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0065 0.0922
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0097 0.0092
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0006 0.0021 0.0016
Brugia malayi nuclear receptor NHR-88 0.0011 0.0089 0.0114
Loa Loa (eye worm) animal heme peroxidase 0.05 0.7477 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0024 0.0056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0097 0.0092
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Toxoplasma gondii ABC1 family protein 0.0038 0.0502 0.5382
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0011 0.0097 0.0092
Schistosoma mansoni hypothetical protein 0.0179 0.2625 0.2622
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0014 0.0009
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0089 0.0085
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0069 0.0086
Onchocerca volvulus 0.0038 0.0502 0.0665
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0065 0.0922
Brugia malayi Animal haem peroxidase family protein 0.05 0.7477 1
Brugia malayi steroid hormone receptor 0.0011 0.0089 0.0114
Brugia malayi hypothetical protein 0.05 0.7477 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0097 0.0092
Brugia malayi G-protein coupled receptor 0.0011 0.0097 0.0123
Echinococcus granulosus bloom syndrome protein 0.0022 0.0268 0.0264
Brugia malayi Dopamine receptor 0.0011 0.0097 0.0123
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Echinococcus multilocularis cpg binding protein 0.0029 0.0372 0.0367
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.0057 0.007
Plasmodium vivax thioredoxin reductase, putative 0.0066 0.0932 1
Brugia malayi larval opioid receptor 0.0011 0.0097 0.0123
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0097 0.0092
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0158 0.1507
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0276 0.2665
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0089 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0065 0.0922
Loa Loa (eye worm) hypothetical protein 0.05 0.7477 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0097 0.0092
Echinococcus granulosus protein cereblon 0.0315 0.4687 0.4685
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0006 0.0021 0.0016
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.0009 0.0065 0.0922
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0089 0.0114
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0097 0.0092
Onchocerca volvulus Peroxidase homolog 0.05 0.7477 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0979 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0011 0.0097 0.0092
Onchocerca volvulus 0.0006 0.0021 0.0022
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0089 0.0085
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0089 0.0085
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0097 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0024 0.0056
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0024 0.0056
Schistosoma mansoni cpg binding protein 0.0028 0.0348 0.0343
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0089 0.0085
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0089 0.0085
Echinococcus granulosus dro:myosuppressin receptor 0.0011 0.0097 0.0092
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0097 0.0092
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0155 0.1668
Loa Loa (eye worm) blistered cuticle protein 3 0.05 0.7477 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.0502 0.1347
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0024 0.0056
Onchocerca volvulus 0.0011 0.0097 0.0123
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0502 0.0497
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Echinococcus granulosus neuropeptide receptor 0.0011 0.0097 0.0092
Mycobacterium ulcerans beta-lactamase 0.0038 0.0502 1
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0065 0.0922
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0014 0.0012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0276 0.2665
Plasmodium falciparum glutathione reductase 0.0066 0.0932 1
Onchocerca volvulus 0.0011 0.0097 0.0123
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0023 0.0276 0.2803
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0065 0.0922
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0023 0.0276 0.2964
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0023 0.0276 0.2665
Loa Loa (eye worm) hypothetical protein 0.0011 0.0089 0.0114
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Trichomonas vaginalis mercuric reductase, putative 0.0023 0.0276 0.5313
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0097 0.0092
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Leishmania major hypothetical protein, conserved 0.0038 0.0502 0.5016
Echinococcus granulosus dnaJ subfamily B 0.0395 0.5898 0.5896
Echinococcus granulosus thioredoxin glutathione reductase 0.0066 0.0932 0.0928
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0276 0.2665
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0089 0.0114
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0006 0.0021 0.0016
Brugia malayi glutathione reductase 0.0066 0.0932 0.1241
Schistosoma mansoni cpg binding protein 0.0029 0.0372 0.0367
Onchocerca volvulus 0.0011 0.0089 0.0114
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0502 0.1347
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0979 1
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0097 0.0092
Loa Loa (eye worm) hypothetical protein 0.05 0.7477 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0097 0.0092
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0089 0.0085
Echinococcus multilocularis thioredoxin glutathione reductase 0.0066 0.0932 0.0928
Loa Loa (eye worm) hypothetical protein 0.05 0.7477 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0011 0.0097 0.0123
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0979 0.1304
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0097 0.0092
Echinococcus multilocularis G protein coupled receptor 139 0.0011 0.0097 0.0092
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0023 0.0276 0.2665
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0089 0.0085
Echinococcus granulosus neuropeptide receptor A26 0.0011 0.0097 0.0092
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0023 0.0276 0.0272
Echinococcus granulosus fmrfamide receptor 0.0011 0.0097 0.0092
Echinococcus granulosus g-protein coupled receptor 0.0011 0.0097 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0024 0.0056
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0097 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0065 0.0922
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0011 0.0097 0.0123
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0276 1
Echinococcus granulosus g protein coupled receptor 0.0011 0.0097 0.0092
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0242 0.3589 1
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0502 0.5016
Echinococcus multilocularis thyroid hormone receptor alpha 0.0143 0.2093 0.2089
Loa Loa (eye worm) hypothetical protein 0.0009 0.0069 0.0086
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0097 0.0092
Toxoplasma gondii selenide, water dikinase 0.0006 0.0021 0.0224
Loa Loa (eye worm) hypothetical protein 0.05 0.7477 1
Onchocerca volvulus 0.0038 0.0502 0.0665
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0012
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0097 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0089 0.0114
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0011 0.0097 0.0092
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0058 0.0072
Schistosoma mansoni amine GPCR 0.0011 0.0097 0.0092
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0014 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0097 0.0092
Echinococcus granulosus g protein coupled receptor 0.0011 0.0097 0.0092
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Plasmodium vivax glutathione reductase, putative 0.0066 0.0932 1
Brugia malayi RE15519p 0.0011 0.0097 0.0123
Onchocerca volvulus Chorion peroxidase homolog 0.05 0.7477 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Onchocerca volvulus 0.05 0.7477 1
Giardia lamblia Hypothetical protein 0.0009 0.0065 0.1735
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0097 0.0092
Onchocerca volvulus 0.0011 0.0097 0.0123
Brugia malayi Animal haem peroxidase family protein 0.05 0.7477 1
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0006 0.0021 0.0022
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0006 0.0021 0.0016
Brugia malayi nuclear hormone receptor 0.0011 0.0089 0.0114
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0006 0.0021 0.0224
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0502 0.1347
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0089 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0065 0.0922
Loa Loa (eye worm) melatonin receptor type 1A 0.0011 0.0097 0.0123
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0097 0.0092
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0023 0.0276 0.2803
Echinococcus granulosus neuropeptide receptor 0.0011 0.0097 0.0092
Onchocerca volvulus Neuropeptide F receptor homolog 0.0011 0.0097 0.0123
Loa Loa (eye worm) hypothetical protein 0.0038 0.0502 0.0665
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0089 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0089 0.0114
Brugia malayi Blistered cuticle protein 3 0.05 0.7477 1
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0065 0.0922
Schistosoma mansoni neuropeptide receptor 0.0011 0.0097 0.0092
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Schistosoma mansoni biogenic amine receptor 0.0011 0.0097 0.0092
Schistosoma mansoni cpg binding protein 0.0029 0.0372 0.0367
Onchocerca volvulus 0.0011 0.0097 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0065 0.0922
Schistosoma mansoni microtubule-associated protein tau 0.0667 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0097 0.0092
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0023 0.0276 0.5313
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0006 0.0021 0.0016
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0097 0.0092
Brugia malayi Dopamine receptor protein 2 0.0011 0.0097 0.0123
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0979 0.0975
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0097 0.0092
Echinococcus multilocularis protein cereblon 0.0315 0.4687 0.4685
Trichomonas vaginalis helicase, putative 0.0006 0.0024 0.0056
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0069 0.1875
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0065 0.0922
Echinococcus multilocularis glutamate synthase 0.0006 0.0021 0.0016
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0502 1
Echinococcus granulosus somatostatin receptor 0.0011 0.0097 0.0092
Giardia lamblia NADH oxidase lateral transfer candidate 0.0023 0.0276 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0097 0.0092
Onchocerca volvulus Dual oxidase homolog 0.05 0.7477 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.011 0.093
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0089 0.0114
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0097 0.0123
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0502 0.1347
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0097 0.0092
Loa Loa (eye worm) hypothetical protein 0.0038 0.0502 0.0665
Loa Loa (eye worm) animal heme peroxidase 0.05 0.7477 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0089 0.0114
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0011 0.0097 0.0123
Loa Loa (eye worm) hypothetical protein 0.05 0.7477 1
Loa Loa (eye worm) animal heme peroxidase 0.05 0.7477 1
Trypanosoma cruzi trypanothione reductase, putative 0.0066 0.0932 0.9507
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0818 0.0814
Schistosoma mansoni disulfide oxidoreductase 0.0006 0.0021 0.0016
Mycobacterium ulcerans hydrolase 0.0009 0.0065 0.0922
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0066 0.0932 0.2553
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0023 0.0276 0.5313
Loa Loa (eye worm) hypothetical protein 0.05 0.7477 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0979 0.0975
Onchocerca volvulus 0.0011 0.0097 0.0123
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0348 0.0459
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0089 0.0114
Entamoeba histolytica recQ family helicase, putative 0.0012 0.011 0.0235
Schistosoma mansoni thyroid hormone receptor 0.0143 0.2093 0.2089
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Mycobacterium tuberculosis Probable oxidoreductase 0.0023 0.0276 0.0716
Brugia malayi Melatonin receptor type 1A 0.0011 0.0097 0.0123
Echinococcus multilocularis serotonin receptor 0.0011 0.0097 0.0092
Echinococcus granulosus tachykinin peptides receptor 99D 0.0011 0.0097 0.0092
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0276 0.2665
Loa Loa (eye worm) hypothetical protein 0.0038 0.0502 0.0665
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0502 1
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0065 0.0922
Onchocerca volvulus 0.0038 0.0502 0.0665
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0011 0.0097 0.0092
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0097 0.0092
Loa Loa (eye worm) hypothetical protein 0.0011 0.0089 0.0114
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0033 0.0028
Onchocerca volvulus 0.0011 0.0097 0.0123
Brugia malayi hypothetical protein 0.0011 0.0097 0.0123
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Mycobacterium leprae Probable lipase LipE 0.0038 0.0502 1
Loa Loa (eye worm) hypothetical protein 0.05 0.7477 1
Loa Loa (eye worm) hypothetical protein 0.0334 0.4977 0.6655
Loa Loa (eye worm) hypothetical protein 0.0011 0.0089 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0089 0.0114
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0011 0.0097 0.0092
Onchocerca volvulus 0.05 0.7477 1
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0006 0.0021 0.0016
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0006 0.0021 0.0044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0097 0.0092
Schistosoma mansoni peroxidasin 0.05 0.7477 0.7476
Loa Loa (eye worm) hypothetical protein 0.0011 0.0089 0.0114
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0276 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0011 0.0097 0.0092
Onchocerca volvulus 0.0011 0.0097 0.0123
Echinococcus granulosus g protein coupled receptor 0.0011 0.0097 0.0092
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0006 0.0021 0.0044
Schistosoma mansoni neuropeptide receptor 0.0011 0.0097 0.0092
Echinococcus multilocularis g-protein coupled receptor 0.0011 0.0097 0.0092
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0089 0.0114
Echinococcus multilocularis microtubule associated protein 2 0.0667 1 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0014 0.0009
Loa Loa (eye worm) hypothetical protein 0.0315 0.4687 0.6266
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0089 0.0085
Brugia malayi Tachykinin-like peptides receptor 99D 0.0011 0.0097 0.0123
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0097 0.0092
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0006 0.0021 0.0022
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0979 1
Schistosoma mansoni hypothetical protein 0.0011 0.0097 0.0092
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0024 0.0056
Schistosoma mansoni neuropeptide receptor 0.0011 0.0097 0.0092
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0089 0.0085
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0133 0.1932 0.1928
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0065 0.0922
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0097 0.0092
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0069 0.0086
Trichomonas vaginalis esterase, putative 0.0038 0.0502 1
Leishmania major trypanothione reductase 0.0066 0.0932 0.9507
Brugia malayi beta-lactamase family protein 0.0038 0.0502 0.0665
Plasmodium falciparum thioredoxin reductase 0.0066 0.0932 1
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0097 0.0123
Giardia lamblia Hypothetical protein 0.0009 0.0065 0.1735
Schistosoma mansoni hypothetical protein 0.0395 0.5898 0.5896
Loa Loa (eye worm) animal heme peroxidase 0.05 0.7477 1
Schistosoma mansoni opsin-like receptor 0.0011 0.0097 0.0092
Brugia malayi GnHR receptor homolog 0.0011 0.0097 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0024 0.0056
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0089 0.0114
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0011 0.0097 0.0092
Mycobacterium ulcerans sulfatase 0.0009 0.0065 0.0922
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0089 0.0085
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0089 0.0085
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0097 0.0092
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0011 0.0097 0.0092
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0097 0.0092
Entamoeba histolytica thioredoxin reductase, putative 0.0006 0.0021 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0065 0.0922
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0065 0.0922
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0097 0.0092
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0014 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0065 0.0922
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0097 0.0092
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0097 0.0092
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0097 0.0092
Echinococcus granulosus hypothetical protein 0.0011 0.0097 0.0092
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0123
Loa Loa (eye worm) RecQ helicase 0.0022 0.0268 0.0353
Mycobacterium tuberculosis Possible hydrolase 0.0009 0.0065 0.0124

Activities

Activity type Activity value Assay description Source Reference
logP (ADMET) = -0.91 Partition coefficient (logP) ChEMBL. 7473552

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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