TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 435.496 | Formula: C23H21N3O4S
H donors: 3 H acceptors: 4 LogP: 3.13 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O=C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CNS(=O)(=O)c1cccc2c1cccc2
InChi: 1S/C23H21N3O4S/c27-15-18(12-17-13-24-21-10-4-3-8-19(17)21)26-23(28)14-25-31(29,30)22-11-5-7-16-6-1-2-9-20(16)22/h1-11,13,15,18,24-25H,12,14H2,(H,26,28)/t18-/m1/s1
InChiKey: OUJSKEQQBPYQMY-GOSISDBHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Homo sapiens	cathepsin L	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0032	0.1106	0.4988
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.1106	0.1302
Echinococcus granulosus	cathepsin b	0.0171	0.8496	1
Leishmania major	cathepsin L-like protease	0.0032	0.1106	0.3763
Brugia malayi	Cathepsin L-like precursor	0.0032	0.1106	0.1106
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1106	0.4282
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0411	0.3713
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1106	0.4282
Brugia malayi	Papain family cysteine protease containing protein	0.0032	0.1106	0.1106
Echinococcus granulosus	cathepsin L cysteine protease	0.0019	0.0411	0.0484
Onchocerca volvulus		0.0032	0.1106	0.1124
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0411	0.3713
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0411	0.3713
Echinococcus multilocularis	leucyl tRNA synthetase	0.002	0.048	0.0565
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0032	0.1106	0.4282
Chlamydia trachomatis	leucine--tRNA ligase	0.002	0.048	1
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0015	0.0215	0.0253
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0632	0.0632
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1106	0.4282
Echinococcus granulosus	cathepsin b	0.0171	0.8496	1
Toxoplasma gondii	tRNA ligases class I (M) protein	0.002	0.048	0.1858
Echinococcus multilocularis	GPCR, family 2	0.0063	0.2759	0.3247
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0411	0.3713
Onchocerca volvulus	Cathepsin F homolog	0.0032	0.1106	0.1124
Treponema pallidum	methionyl-tRNA synthetase	0.002	0.048	1
Echinococcus granulosus	cysteine protease	0.0019	0.0411	0.0484
Loa Loa (eye worm)	hypothetical protein	0.002	0.048	0.048
Loa Loa (eye worm)	hypothetical protein	0.002	0.048	0.048
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0032	0.1106	0.1302
Mycobacterium ulcerans	methionyl-tRNA synthetase	0.0053	0.2218	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0023	0.0632	0.0632
Echinococcus multilocularis	cathepsin L cysteine protease	0.0032	0.1106	0.1302
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0032	0.1106	0.4988
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.1106	0.4282
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0411	0.3713
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1106	0.4282
Wolbachia endosymbiont of Brugia malayi	methionyl-tRNA synthetase	0.0053	0.2218	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0632	0.0632
Schistosoma mansoni	methionine-tRNA synthetase	0.0053	0.2218	0.2611
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0411	0.0411
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1106	0.4282
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1106	0.4282
Plasmodium vivax	vivapain-1	0.0019	0.0411	0.1852
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.006	0.2584	1
Giardia lamblia	Cathepsin B precursor	0.006	0.2584	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1106	0.4282
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0171	0.8496	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.1106	0.1302
Brugia malayi	cathepsin B-like cysteine proteinase	0.0171	0.8496	0.8496
Leishmania major	cysteine peptidase A (CPA)	0.0032	0.1106	0.3763
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0063	0.2759	0.2759
Brugia malayi	Cathepsin L-like precursor	0.0032	0.1106	0.1106
Loa Loa (eye worm)	tyrosyl-tRNA synthetase	0.0033	0.1145	0.1145
Leishmania major	cathepsin L-like protease	0.0032	0.1106	0.3763
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0019	0.0411	0.159
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0019	0.0411	0.1852
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.8496	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.1106	0.4282
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0063	0.2759	0.3247
Onchocerca volvulus		0.0032	0.1106	0.1124
Brugia malayi	Isocitrate dehydrogenase	0.0015	0.0215	0.0215
Brugia malayi	Cathepsin L-like precursor	0.0032	0.1106	0.1106
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.006	0.2584	0.3041
Echinococcus multilocularis	cathepsin L cysteine protease	0.0032	0.1106	0.1302
Giardia lamblia	Methionyl-tRNA synthetase	0.0053	0.2218	0.8585
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0015	0.0215	0.0253
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.1106	0.1302
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.1106	0.1302
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0015	0.0215	0.0253
Trypanosoma brucei	methionyl-tRNA synthetase, putative	0.0053	0.2218	0.8585
Echinococcus multilocularis	methionyl tRNA synthetase, cytoplasmic	0.002	0.048	0.0565
Echinococcus multilocularis	cathepsin b	0.0171	0.8496	1
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0411	0.3713
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1106	0.4282
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0215	0.0832
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0632	0.2447
Giardia lamblia	Leucyl-tRNA synthetase	0.002	0.048	0.1858
Loa Loa (eye worm)	hypothetical protein	0.0196	0.9839	0.9839
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.8496	1
Leishmania major	cathepsin L-like protease	0.0032	0.1106	0.3763
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.1106	0.4282
Onchocerca volvulus		0.0023	0.0632	0.0642
Echinococcus granulosus	methionine tRNA synthetase	0.0053	0.2218	0.2611
Leishmania major	cathepsin L-like protease	0.0032	0.1106	0.3763
Plasmodium vivax	vivapain-2	0.0032	0.1106	0.4988
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.8496	1
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0411	0.3713
Leishmania major	leucyl-tRNA synthetase, putative	0.002	0.048	0.112
Echinococcus granulosus	cathepsin L	0.0019	0.0411	0.0484
Toxoplasma gondii	cathepsin CPL	0.0032	0.1106	0.4282
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0015	0.0215	0.0215
Schistosoma mansoni	cathepsin F (C01 family)	0.0032	0.1106	0.1302
Onchocerca volvulus		0.0033	0.1145	0.1164
Toxoplasma gondii	isocitrate dehydrogenase	0.0015	0.0215	0.0832
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0063	0.2759	0.3247
Schistosoma mansoni	hypothetical protein	0.0063	0.2759	0.3247
Mycobacterium leprae	Probable methionyl-tRNA synthase MetS	0.0053	0.2218	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0019	0.0411	0.0484
Echinococcus multilocularis	isocitrate dehydrogenase	0.0015	0.0215	0.0253
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0196	0.9839	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1106	0.4282
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1106	0.4282
Leishmania major	cathepsin L-like protease	0.0032	0.1106	0.3763
Echinococcus granulosus	GPCR family 2	0.0063	0.2759	0.3247
Plasmodium vivax	unspecified product	0.0019	0.0411	0.1852
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0411	0.3713
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1106	0.4282
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0215	0.0253
Loa Loa (eye worm)	hypothetical protein	0.0032	0.1106	0.1106
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0215	0.0253
Trichomonas vaginalis	methionine-tRNA synthetase, putative	0.0053	0.2218	0.8585
Echinococcus granulosus	cathepsin l1	0.0032	0.1106	0.1302
Trypanosoma cruzi	cysteine proteinase, putative	0.0019	0.0411	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0632	0.0632
Brugia malayi	methionyl-tRNA synthetase	0.0053	0.2218	0.2218
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1106	0.4282
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.1106	0.4282
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0015	0.0215	0.0969
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1106	0.4282
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.0411	0.0484
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0032	0.1106	0.1106
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.1106	0.4282
Echinococcus multilocularis	cathepsin b	0.0171	0.8496	1
Echinococcus multilocularis	cathepsin L	0.0019	0.0411	0.0484
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0411	0.3713
Treponema pallidum	leucyl-tRNA synthetase	0.002	0.048	1
Onchocerca volvulus		0.0032	0.1106	0.1124
Trypanosoma brucei	cysteine peptidase C (CPC)	0.006	0.2584	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.006	0.2584	0.3041
Loa Loa (eye worm)	cathepsin B	0.006	0.2584	0.2584
Brugia malayi	methionyl-tRNA synthetase	0.002	0.048	0.048
Leishmania major	methionyl-tRNA synthetase, putative	0.0053	0.2218	0.8456
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0019	0.0411	0.0484
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1106	0.4282
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0411	0.0411
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.0411	0.0484
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0032	0.1106	0.1302
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.1106	1
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.1106	1
Onchocerca volvulus		0.0032	0.1106	0.1124
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0632	0.2447
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1106	0.4282
Loa Loa (eye worm)	cysteine protease	0.0032	0.1106	0.1106
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1106	0.4282
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.006	0.2584	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1106	0.4282
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0015	0.0215	0.0832
Loa Loa (eye worm)	hypothetical protein	0.0063	0.2759	0.2759
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1106	0.4282
Toxoplasma gondii	isocitrate dehydrogenase	0.0015	0.0215	0.0832
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0411	0.3713
Brugia malayi	Cathepsin L-like precursor	0.0032	0.1106	0.1106
Onchocerca volvulus		0.0032	0.1106	0.1124
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0215	0.0253
Entamoeba histolytica	cysteine proteinase 1, putative	0.0019	0.0411	0.3713
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0019	0.0411	0.159
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0063	0.2759	0.3247
Echinococcus granulosus	methionyl tRNA synthetase cytoplasmic	0.002	0.048	0.0565
Plasmodium vivax	vivapain-3	0.0019	0.0411	0.1852
Brugia malayi	Latrophilin receptor protein 2	0.0063	0.2759	0.2759
Echinococcus multilocularis	cysteine protease	0.0032	0.1106	0.1302
Loa Loa (eye worm)	fibroinase	0.0032	0.1106	0.1106
Brugia malayi	isocitrate dehydrogenase	0.0015	0.0215	0.0215
Loa Loa (eye worm)	hypothetical protein	0.002	0.048	0.048
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0411	0.159
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0411	0.3713
Brugia malayi	Cathepsin L-like precursor	0.0032	0.1106	0.1106
Giardia lamblia	Cathepsin B precursor	0.006	0.2584	1
Loa Loa (eye worm)	methionyl-tRNA synthetase	0.0053	0.2218	0.2218
Brugia malayi	protein ZK524.3	0.002	0.048	0.048
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0411	0.3713
Leishmania major	cathepsin L-like protease	0.0032	0.1106	0.3763
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0032	0.1106	0.1302
Mycobacterium tuberculosis	Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase)	0.0053	0.2218	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1106	0.4282
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0171	0.8496	1
Schistosoma mansoni	hypothetical protein	0.0063	0.2759	0.3247
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.1106	0.4282
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0063	0.2759	0.3247
Entamoeba histolytica	cysteine protease, putative	0.0032	0.1106	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1106	0.4282
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0215	0.0253
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0023	0.0632	0.0744
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0032	0.1106	0.4282
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0632	0.0632
Brugia malayi	cathepsin L-like precursor	0.0023	0.0632	0.0632
Plasmodium falciparum	methionine--tRNA ligase, putative	0.002	0.048	0.2165
Trypanosoma cruzi	cysteine proteinase, putative	0.0019	0.0411	0.0484
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0411	0.3713
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0411	0.3713
Echinococcus multilocularis	cysteine protease	0.0032	0.1106	0.1302
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0411	0.159
Entamoeba histolytica	methionyl-tRNA synthetase, putative	0.002	0.048	0.434
Loa Loa (eye worm)	hypothetical protein	0.0136	0.6648	0.6648
Plasmodium vivax	methionine--tRNA ligase, putative	0.0053	0.2218	1
Onchocerca volvulus	Cathepsin L homolog	0.0032	0.1106	0.1124
Toxoplasma gondii	cathepsin B	0.006	0.2584	1
Schistosoma mansoni	hypothetical protein	0.0063	0.2759	0.3247
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1106	0.4282
Plasmodium falciparum	methionine--tRNA ligase	0.0053	0.2218	1
Onchocerca volvulus		0.0032	0.1106	0.1124
Plasmodium vivax	hypothetical protein, conserved	0.002	0.048	0.2165
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0032	0.1106	0.1302
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0015	0.0215	0.0969
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.1106	0.4282
Schistosoma mansoni	hypothetical protein	0.0136	0.6648	0.7826
Leishmania major	cathepsin L-like protease	0.0032	0.1106	0.3763
Echinococcus granulosus	cathepsin l1	0.0023	0.0632	0.0744
Onchocerca volvulus		0.0032	0.1106	0.1124
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0199	1	1
Loa Loa (eye worm)	ctsf protein	0.0032	0.1106	0.1106
Brugia malayi	N-terminal motif family protein	0.0196	0.9839	0.9839
Entamoeba histolytica	cysteine proteinase 2	0.0019	0.0411	0.3713
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0411	0.3713
Loa Loa (eye worm)	hypothetical protein	0.0199	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1106	0.4282
Plasmodium vivax	methionine--tRNA ligase, putative	0.002	0.048	0.2165
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1106	0.4282
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1106	0.4282
Schistosoma mansoni	hypothetical protein	0.0063	0.2759	0.3247
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0199	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.0411	0.0484
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0015	0.0215	0.0253
Loa Loa (eye worm)	hypothetical protein	0.0171	0.8496	0.8496
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0411	0.3713
Mycobacterium ulcerans	leucyl-tRNA synthetase	0.002	0.048	0.2165
Brugia malayi	Cathepsin L-like precursor	0.0032	0.1106	0.1106
Chlamydia trachomatis	methionine--tRNA ligase	0.002	0.048	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0063	0.2759	0.2759
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0632	0.0632
Entamoeba histolytica	cysteine proteinase, putative	0.0023	0.0632	0.5714
Trypanosoma cruzi	cysteine protease, putative	0.0019	0.0411	0.0484
Giardia lamblia	Cathepsin B precursor	0.006	0.2584	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0023	0.0632	0.0744
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0032	0.1106	0.1106
Toxoplasma gondii	methionyl-tRNA synthetase	0.0053	0.2218	0.8585
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0032	0.1106	0.4988
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.1106	0.4282
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0411	0.3713
Leishmania major	cathepsin L-like protease	0.0032	0.1106	0.3763
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1106	0.4282
Schistosoma mansoni	cathepsin F (C01 family)	0.0032	0.1106	0.1302
Trypanosoma cruzi	cruzipain precursor, putative	0.0032	0.1106	0.1302
Wolbachia endosymbiont of Brugia malayi	leucyl-tRNA synthetase	0.002	0.048	0.2165
Plasmodium vivax	vivapain-2	0.0032	0.1106	0.4988
Brugia malayi	latrophilin 2 splice variant baaae	0.0136	0.6648	0.6648
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.1106	0.4282
Echinococcus multilocularis	methionine tRNA synthetase	0.0053	0.2218	0.2611
Schistosoma mansoni	leucyl-tRNA synthetase	0.002	0.048	0.0565
Trypanosoma cruzi	methionyl-tRNA synthetase, putative	0.0053	0.2218	0.2611
Schistosoma mansoni	methionine-tRNA synthetase	0.002	0.048	0.0565
Onchocerca volvulus	Cathepsin L homolog	0.0032	0.1106	0.1124

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 150 nM	Inhibition of human cathepsin L.	ChEMBL.	9784105
IC50 (binding)	= 150 nM	Inhibition of human cathepsin L.	ChEMBL.	9784105
IC50 (binding)	> 1000 nM	Inhibition of human cathepsin B	ChEMBL.	9784105
IC50 (binding)	> 1000 nM	Inhibition of human cathepsin B	ChEMBL.	9784105
Ratio (binding)	< 6	Ratio of IC50 for Cathepsin B to that for Cathepsin L	ChEMBL.	9784105

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL336748

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 233034