Detailed information for compound 233424

Basic information

Technical information
  • TDR Targets ID: 233424
  • Name: 1-[[4-(4-chlorophenyl)-1H-pyrrol-3-yl]-naphth alen-1-ylmethyl]imidazole
  • MW: 383.873 | Formula: C24H18ClN3
  • H donors: 1 H acceptors: 1 LogP: 5.6 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)c1c[nH]cc1C(c1cccc2c1cccc2)n1ccnc1
  • InChi: 1S/C24H18ClN3/c25-19-10-8-18(9-11-19)22-14-27-15-23(22)24(28-13-12-26-16-28)21-7-3-5-17-4-1-2-6-20(17)21/h1-16,24,27H
  • InChiKey: MFLFXULGUYILBI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[[4-(4-chlorophenyl)-1H-pyrrol-3-yl]-(1-naphthyl)methyl]imidazole
  • 1-[[4-(4-chlorophenyl)-1H-pyrrol-3-yl]-(1-naphthalenyl)methyl]imidazole
  • 1-[[4-(4-chlorophenyl)-1H-pyrrol-3-yl]-naphthalen-1-yl-methyl]imidazole
  • 170938-96-2
  • 1H-Imidazole, 1-((4-(4-chlorophenyl)-1H-pyrrol-3-yl)-1-naphthalenylmethyl)-
  • 1H-Imidazole, 1-[[4-(4-chlorophenyl)-1H-pyrrol-3-yl]-1-naphthalenylmethyl]-
  • AIDS-045437
  • AIDS045437

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni aldehyde dehydrogenase 0.0033 0.052 0.2919
Echinococcus multilocularis peptidase Clp (S14 family) 0.0023 0.0292 0.0292
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Echinococcus multilocularis musashi 0.0015 0.0128 0.0128
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.002 0.0244 0.2265
Echinococcus granulosus neuropeptide receptor 0.0012 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0074 0.0418
Trypanosoma cruzi O-6 methyl-guanine alkyl transferase, putative 0.0026 0.0358 0.3323
Trichomonas vaginalis myo inositol monophosphatase, putative 0.002 0.0244 0.044
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0074 0.0074
Trichomonas vaginalis inositol monophosphatase, putative 0.002 0.0244 0.044
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.006 0.1077 1
Trichomonas vaginalis penicillin-binding protein, putative 0.002 0.0233 0.042
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0696 0.391
Echinococcus granulosus 7tm_1 domain containing protein 0.0012 0.0074 0.0074
Mycobacterium tuberculosis Hypothetical protein 0.002 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.003 0.0455 0.0982
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.0484 1 1
Trichomonas vaginalis methylated-DNA--protein-cysteine methyltransferase, putative 0.0026 0.0358 0.0645
Brugia malayi hypothetical protein 0.0054 0.0955 0.2059
Entamoeba histolytica myo-inositol monophosphatase, putative 0.002 0.0244 0.2388
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0042 0.0696 0.1501
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0074 0.0074
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0272 0.555 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0033 0.052 0.052
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0074 0.0418
Loa Loa (eye worm) matrixin family protein 0.0067 0.1235 0.2662
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Onchocerca volvulus 0.0012 0.0074 0.016
Mycobacterium tuberculosis Probable dehydrogenase 0.0048 0.0819 0.0819
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0012 0.0074 0.016
Brugia malayi neuropeptide F receptor 0.0012 0.0074 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0074 0.0074
Brugia malayi Matrixin family protein 0.003 0.0455 0.0982
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0012 0.0074 0.0074
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0012 0.0066 0.0614
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0012 0.0074 0.016
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0074 0.0074
Onchocerca volvulus 0.0043 0.0723 0.1558
Onchocerca volvulus 0.0012 0.0074 0.016
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0074 0.0418
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0132 0.0132
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0012 0.0063 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0242 0.0436
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0081 0.1515 0.1515
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0132 0.0132
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0074 0.0074
Onchocerca volvulus 0.0043 0.0712 0.1535
Echinococcus granulosus lamin dm0 0.0015 0.0128 0.0128
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0048 0.0819 0.2867
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0696 0.1255
Chlamydia trachomatis methylated-DNA protein-cysteine methyltransferase 0.0026 0.0358 0.6596
Echinococcus multilocularis g-protein coupled receptor 0.0012 0.0074 0.0074
Onchocerca volvulus 0.0012 0.0074 0.016
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0132 0.0284
Loa Loa (eye worm) hypothetical protein 0.002 0.0233 0.0503
Echinococcus multilocularis tumor protein p63 0.0149 0.2958 0.2958
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0017 0.018 0.101
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0012 0.0074 0.0418
Plasmodium vivax thioredoxin reductase, putative 0.0021 0.0255 0.237
Loa Loa (eye worm) hypothetical protein 0.003 0.0455 0.0982
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0035 0.0543 0.0543
Schistosoma mansoni hypothetical protein 0.0027 0.0375 0.2106
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0035 0.0543 0.1816
Echinococcus granulosus dihydrofolate reductase 0.0017 0.0181 0.0181
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.002 0.0233 0.0233
Toxoplasma gondii aldehyde dehydrogenase 0.0033 0.052 0.4825
Brugia malayi serine/threonine-protein kinase plk-2 0.0042 0.0696 0.1501
Toxoplasma gondii hypothetical protein 0.0012 0.0066 0.0614
Echinococcus granulosus fmrfamide receptor 0.0012 0.0074 0.0074
Onchocerca volvulus Matrix metalloproteinase homolog 0.0067 0.1235 0.2662
Echinococcus multilocularis dihydrofolate reductase 0.0017 0.0181 0.0181
Brugia malayi larval opioid receptor 0.0012 0.0074 0.016
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0074 0.0074
Loa Loa (eye worm) dihydrofolate reductase 0.0017 0.0181 0.039
Brugia malayi Matrixin family protein 0.003 0.0455 0.0982
Schistosoma mansoni hypothetical protein 0.0015 0.0132 0.074
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0035 0.0543 0.5038
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.006 0.1077 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0074 0.016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0074 0.0418
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0074 0.0074
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0012 0.0063 0.0582
Schistosoma mansoni histamine h1 receptor 0.0012 0.0074 0.0418
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0074 0.0074
Echinococcus multilocularis beta LACTamase domain containing family member 0.002 0.0233 0.0233
Loa Loa (eye worm) transcription factor SMAD2 0.0053 0.0926 0.1996
Schistosoma mansoni adenoreceptor 0.0012 0.0074 0.0418
Schistosoma mansoni inositol monophosphatase 0.002 0.0244 0.137
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0074 0.0074
Echinococcus multilocularis survival motor neuron protein 1 0.013 0.2558 0.2558
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0052 0.091 0.091
Loa Loa (eye worm) hypothetical protein 0.0022 0.0276 0.0594
Mycobacterium tuberculosis Conserved protein 0.002 0.0233 0.0233
Trichomonas vaginalis CMGC family protein kinase 0.0012 0.0063 0.0113
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0043 0.0712 0.0712
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0696 0.1255
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0696 0.1255
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0012 0.0063 0.0582
Schistosoma mansoni hypothetical protein 0.0043 0.0723 0.4059
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0035 0.0543 1
Plasmodium vivax ataxin-2 like protein, putative 0.0014 0.0108 0.1002
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0074 0.0074
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0017 0.018 0.0388
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0074 0.0418
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0012 0.0074 0.0418
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0018 0.0199 0.0507
Echinococcus granulosus beta LACTamase domain containing family member 0.002 0.0233 0.0233
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0074 0.0418
Echinococcus multilocularis serotonin receptor 0.0012 0.0074 0.0074
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0035 0.0543 0.5038
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0012 0.0074 0.0074
Mycobacterium ulcerans aldehyde dehydrogenase 0.0033 0.052 0.052
Schistosoma mansoni hypothetical protein 0.0015 0.0132 0.074
Trypanosoma cruzi PAB1-binding protein , putative 0.0014 0.0108 0.1002
Brugia malayi Tachykinin-like peptides receptor 99D 0.0012 0.0074 0.016
Onchocerca volvulus 0.0012 0.0074 0.016
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0033 0.052 0.4825
Echinococcus granulosus somatostatin receptor 0.0012 0.0074 0.0074
Brugia malayi latrophilin 2 splice variant baaae 0.0032 0.0499 0.1075
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0074 0.0074
Echinococcus multilocularis GPCR, family 2 0.0015 0.0132 0.0132
Echinococcus multilocularis inositol monophosphatase 1 0.002 0.0244 0.0244
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.002 0.0233 0.131
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0696 0.1255
Brugia malayi GnHR receptor homolog 0.0012 0.0074 0.016
Onchocerca volvulus 0.0015 0.0128 0.0277
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0017 0.018 0.018
Schistosoma mansoni neuropeptide receptor 0.0012 0.0074 0.0418
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Loa Loa (eye worm) hypothetical protein 0.002 0.0233 0.0503
Echinococcus granulosus inositol monophosphatase 1 0.002 0.0244 0.0244
Loa Loa (eye worm) beta-lactamase 0.002 0.0233 0.0503
Trypanosoma brucei protein kinase, putative 0.0012 0.0063 0.0582
Plasmodium falciparum ataxin-2 like protein, putative 0.0014 0.0108 0.1002
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0053 0.0931 0.0931
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0043 0.0712 0.2461
Echinococcus multilocularis geminin 0.0093 0.1781 0.1781
Onchocerca volvulus 0.002 0.0233 0.0503
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0074 0.0074
Leishmania major hypothetical protein, conserved 0.0026 0.0358 0.3323
Echinococcus multilocularis neuropeptide s receptor 0.0012 0.0074 0.0074
Brugia malayi putative neuropeptide receptor 0.0012 0.0074 0.016
Echinococcus multilocularis somatostatin receptor 0.0012 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0012 0.0074 0.0418
Brugia malayi hypothetical protein 0.002 0.0242 0.0522
Loa Loa (eye worm) hypothetical protein 0.0015 0.0132 0.0284
Trichomonas vaginalis CMGC family protein kinase 0.0012 0.0063 0.0113
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0074 0.0418
Schistosoma mansoni lamin 0.0015 0.0128 0.0721
Loa Loa (eye worm) TYRA-2 protein 0.0012 0.0074 0.016
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.002 0.0233 0.0233
Mycobacterium ulcerans thymidylate synthase 0.0043 0.0712 0.0712
Mycobacterium leprae PROBABLE HYDROLASE 0.0037 0.0595 0.2015
Toxoplasma gondii LsmAD domain-containing protein 0.0014 0.0108 0.1002
Schistosoma mansoni amine GPCR 0.0012 0.0074 0.0418
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0048 0.0819 0.0819
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0074 0.0074
Brugia malayi Calcitonin receptor-like protein seb-1 0.0047 0.0815 0.1756
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0074 0.0074
Echinococcus multilocularis thymidine phosphorylase 0.0484 1 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0012 0.0074 0.0074
Echinococcus granulosus thymidylate synthase 0.0043 0.0712 0.0712
Giardia lamblia Kinase, PLK 0.0042 0.0696 1
Trypanosoma brucei polo-like protein kinase 0.0042 0.0696 0.6462
Loa Loa (eye worm) matrix metalloproteinase 0.003 0.0455 0.0982
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0012 0.0063 0.0582
Chlamydia trachomatis dihydrofolate reductase 0.0017 0.0181 0.3337
Schistosoma mansoni hypothetical protein 0.0012 0.0074 0.0418
Toxoplasma gondii ABC1 family protein 0.002 0.0233 0.2165
Schistosoma mansoni opsin-like receptor 0.0012 0.0074 0.0418
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0132 0.0284
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0074 0.0074
Echinococcus granulosus neuropeptide FF receptor 2 0.0012 0.0074 0.0074
Treponema pallidum hypothetical protein 0.0036 0.0583 0.7587
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0074 0.0074
Mycobacterium leprae conserved hypothetical protein 0.002 0.0233 0.0636
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0017 0.018 0.0388
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0074 0.0074
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.011 0.2142 0.2142
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (small chain) 0.0052 0.091 0.091
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.006 0.1077 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Loa Loa (eye worm) hypothetical protein 0.0054 0.0955 0.2059
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0047 0.0815 0.1756
Onchocerca volvulus Neuropeptide F receptor homolog 0.0012 0.0074 0.016
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.002 0.0244 0.0244
Schistosoma mansoni myosin xvIII 0.0012 0.0074 0.0418
Mycobacterium ulcerans aldehyde dehydrogenase 0.0033 0.052 0.052
Trichomonas vaginalis penicillin-binding protein, putative 0.002 0.0233 0.042
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0277
Echinococcus granulosus mitogen activated protein kinase 0.0012 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0093 0.1781 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.002 0.0244 0.2265
Echinococcus granulosus g protein coupled receptor 0.0012 0.0074 0.0074
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0074 0.0418
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0042 0.0696 0.0696
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Echinococcus granulosus thioredoxin glutathione reductase 0.0021 0.0255 0.0255
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.002 0.0244 0.2265
Loa Loa (eye worm) intermediate filament protein 0.0015 0.0128 0.0277
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0137 0.269 0.269
Schistosoma mansoni neuropeptide receptor 0.0012 0.0074 0.0418
Schistosoma mansoni alpha-1 adrenergic receptor 0.0012 0.0074 0.0418
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0272 0.555 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0233 0.0503
Echinococcus multilocularis mitogen activated protein kinase 0.0012 0.0063 0.0063
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0017 0.018 0.101
Brugia malayi hypothetical protein 0.0012 0.0074 0.016
Trichomonas vaginalis D-aminoacylase, putative 0.002 0.0233 0.042
Brugia malayi Dopamine receptor protein 2 0.0012 0.0074 0.016
Brugia malayi Hemopexin family protein 0.0043 0.0723 0.1558
Schistosoma mansoni aldehyde dehydrogenase 0.0033 0.052 0.2919
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0017 0.0181 0.0181
Onchocerca volvulus 0.0012 0.0074 0.016
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0035 0.0543 0.5038
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0012 0.0063 0.0582
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0035 0.0543 0.6994
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0074 0.0074
Brugia malayi G-protein coupled receptor 0.0012 0.0074 0.016
Mycobacterium tuberculosis Probable lipase LipE 0.002 0.0233 0.0233
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0128 0.2519 0.2519
Brugia malayi hypothetical protein 0.0012 0.0074 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Trypanosoma cruzi O-6 methyl-guanine alkyl transferase, putative 0.0026 0.0358 0.3323
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0048 0.0819 0.0819
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.002 0.0233 0.131
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Mycobacterium tuberculosis Probable lipase LipD 0.002 0.0233 0.0233
Trichomonas vaginalis CAMK family protein kinase 0.0021 0.0253 0.0455
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0074 0.016
Mycobacterium leprae PROBABLE METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE OGT (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA 0.0078 0.1464 0.5328
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0027 0.0375 0.0809
Brugia malayi hypothetical protein 0.0012 0.0074 0.016
Brugia malayi glutathione reductase 0.0021 0.0255 0.0551
Echinococcus multilocularis lamin dm0 0.0015 0.0128 0.0128
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0042 0.0696 0.0696
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0012 0.0074 0.0074
Entamoeba histolytica serine/threonine protein kinase, putative 0.0042 0.0696 1
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0074 0.0074
Schistosoma mansoni lamin 0.0015 0.0128 0.0721
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0132 0.0132
Brugia malayi hypothetical protein 0.013 0.2558 0.5515
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0033 0.052 0.052
Brugia malayi hypothetical protein 0.0012 0.0074 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Loa Loa (eye worm) inositol-1 0.002 0.0244 0.0526
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0012 0.0063 0.0582
Echinococcus multilocularis G-protein coupled receptor, putative 0.0012 0.0074 0.0074
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0012 0.0074 0.0074
Onchocerca volvulus 0.0012 0.0074 0.016
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0074 0.016
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.002 0.0233 0.0233
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0074 0.0074
Onchocerca volvulus 0.0012 0.0074 0.016
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0233 0.2165
Brugia malayi intermediate filament protein 0.0015 0.0128 0.0277
Plasmodium falciparum thioredoxin reductase 0.0021 0.0255 0.237
Leishmania major trypanothione reductase 0.0021 0.0255 0.237
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0023 0.0292 0.0862
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0012 0.0074 0.0418
Loa Loa (eye worm) hypothetical protein 0.0037 0.0595 0.1283
Brugia malayi hypothetical protein 0.0012 0.0074 0.016
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0012 0.0074 0.016
Schistosoma mansoni peptidase Clp (S14 family) 0.0035 0.0543 0.3048
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.004 0.0657 0.3691
Echinococcus multilocularis dro:myosuppressin receptor 0.0012 0.0074 0.0074
Schistosoma mansoni hypothetical protein 0.0032 0.0499 0.2799
Trypanosoma cruzi polo-like protein kinase, putative 0.0042 0.0696 0.6462
Echinococcus granulosus g protein coupled receptor 0.0012 0.0074 0.0074
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0012 0.0074 0.016
Schistosoma mansoni hypothetical protein 0.0015 0.0132 0.074
Echinococcus granulosus sex peptide receptor 0.0012 0.0074 0.0074
Brugia malayi RE15519p 0.0012 0.0074 0.016
Onchocerca volvulus 0.0022 0.0276 0.0594
Echinococcus granulosus serotonin receptor 0.0012 0.0074 0.0074
Schistosoma mansoni opsin-like receptor 0.0012 0.0074 0.0418
Loa Loa (eye worm) hypothetical protein 0.002 0.0233 0.0503
Brugia malayi hypothetical protein 0.0012 0.0074 0.016
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0074 0.0418
Mycobacterium tuberculosis Methylated-DNA--protein-cysteine methyltransferase Ogt (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA-alkyltra 0.0078 0.1464 0.1464
Schistosoma mansoni neuropeptide f receptor 76f 0.0012 0.0074 0.0418
Brugia malayi Dopamine receptor protein 1 0.0012 0.0074 0.016
Brugia malayi Serotonin receptor 0.0012 0.0074 0.016
Mycobacterium tuberculosis Probable reductase 0.0048 0.0819 0.0819
Schistosoma mansoni growth hormone secretagogue receptor 0.0012 0.0074 0.0418
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0074 0.0074
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0074 0.016
Brugia malayi hypothetical protein 0.0009 0.0004 0.0009
Echinococcus multilocularis neuropeptide receptor A26 0.0012 0.0074 0.0074
Schistosoma mansoni hypothetical protein 0.0012 0.0074 0.0418
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0012 0.0074 0.016
Brugia malayi Inositol-1 0.002 0.0244 0.0526
Echinococcus granulosus tachykinin peptides receptor 99D 0.0012 0.0074 0.0074
Brugia malayi hypothetical protein 0.0012 0.0074 0.016
Schistosoma mansoni kinase 0.0021 0.0264 0.1484
Mycobacterium ulcerans methylated-DNA--protein-cysteine methyltransferase Ogt 0.0078 0.1464 0.1464
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0012 0.0074 0.0074
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.002 0.0244 0.2265
Schistosoma mansoni biogenic amine receptor 0.0012 0.0074 0.0418
Loa Loa (eye worm) thioredoxin reductase 0.0021 0.0255 0.0551
Trypanosoma cruzi polo-like protein kinase, putative 0.0042 0.0696 0.6462
Echinococcus multilocularis lamin 0.0015 0.0128 0.0128
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0023 0.0292 0.0292
Brugia malayi Thioredoxin reductase 0.0021 0.0255 0.0551
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0012 0.0063 0.0582
Echinococcus granulosus g-protein coupled receptor 0.0012 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Brugia malayi sulfakinin receptor protein 0.0012 0.0074 0.016
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0018 0.0199 0.0199
Echinococcus granulosus neuropeptide s receptor 0.0012 0.0074 0.0074
Trichomonas vaginalis CAMK family protein kinase 0.0021 0.0253 0.0455
Echinococcus multilocularis serotonin receptor 0.0012 0.0074 0.0074
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0074 0.0074
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0017 0.0181 0.0181
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0074 0.0074
Trichomonas vaginalis CMGC family protein kinase 0.0012 0.0063 0.0113
Mycobacterium ulcerans thymidine phosphorylase 0.0484 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Loa Loa (eye worm) melatonin receptor type 1A 0.0012 0.0074 0.016
Trichomonas vaginalis esterase, putative 0.002 0.0233 0.042
Brugia malayi Matrixin family protein 0.003 0.0455 0.0982
Leishmania major hypothetical protein, conserved 0.0014 0.0108 0.1002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0017 0.018 0.018
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0074 0.0074
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.006 0.1077 1
Brugia malayi beta-lactamase family protein 0.002 0.0233 0.0503
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0132 0.0132
Trichomonas vaginalis D-aminoacylase, putative 0.002 0.0233 0.042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0074 0.0418
Schistosoma mansoni amine GPCR 0.0012 0.0074 0.0418
Plasmodium vivax hypothetical protein, conserved 0.002 0.0233 0.2165
Brugia malayi Dopamine receptor 0.0012 0.0074 0.016
Echinococcus granulosus hypothetical protein 0.0012 0.0074 0.0074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0017 0.018 0.018
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0074 0.0074
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0037 0.0595 0.0595
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0074 0.0418
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0035 0.0543 0.0543
Loa Loa (eye worm) hypothetical protein 0.0015 0.0123 0.0265
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0012 0.0074 0.016
Onchocerca volvulus Matrilysin homolog 0.003 0.0455 0.0982
Schistosoma mansoni hypothetical protein 0.0014 0.0102 0.0574
Onchocerca volvulus 0.0012 0.0074 0.016
Brugia malayi AKH receptor 0.0012 0.0074 0.016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0074 0.0418
Trypanosoma brucei trypanothione reductase 0.0021 0.0255 0.237
Echinococcus multilocularis orexin receptor type 2 0.0012 0.0074 0.0074
Trypanosoma cruzi trypanothione reductase, putative 0.0021 0.0255 0.237
Brugia malayi beta-lactamase 0.002 0.0233 0.0503
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Treponema pallidum hypothetical protein 0.0044 0.0748 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.002 0.0233 0.0503
Plasmodium vivax glutathione reductase, putative 0.0021 0.0255 0.237
Giardia lamblia Kinase, CMGC MAPK 0.0012 0.0063 0.0901
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0012 0.0074 0.0074
Plasmodium falciparum glutathione reductase 0.0021 0.0255 0.237
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0012 0.0074 0.016
Schistosoma mansoni amine GPCR 0.0012 0.0074 0.0418
Onchocerca volvulus 0.0012 0.0074 0.016
Schistosoma mansoni hypothetical protein 0.0015 0.0132 0.074
Loa Loa (eye worm) hypothetical protein 0.0035 0.0543 0.117
Onchocerca volvulus 0.0027 0.0375 0.0809
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Schistosoma mansoni cellular tumor antigen P53 0.0022 0.0276 0.1547
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Onchocerca volvulus 0.0012 0.0074 0.016
Mycobacterium ulcerans beta-lactamase 0.002 0.0233 0.0233
Echinococcus multilocularis neuropeptide FF receptor 2 0.0012 0.0074 0.0074
Schistosoma mansoni inositol monophosphatase 0.002 0.0244 0.137
Echinococcus multilocularis sex peptide receptor 0.0012 0.0074 0.0074
Brugia malayi Matrixin family protein 0.003 0.0455 0.0982
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0037 0.0595 0.1283
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0074 0.0074
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0053 0.0931 0.3294
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0035 0.0543 0.5038
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0035 0.0543 0.0543
Echinococcus granulosus intermediate filament protein 0.0015 0.0128 0.0128
Brugia malayi Serotonin receptor 0.0012 0.0074 0.016
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.011 0.2142 0.2142
Trypanosoma brucei hypothetical protein, conserved 0.001 0.0036 0.0336
Onchocerca volvulus 0.0015 0.0128 0.0277
Trypanosoma brucei PAB1-binding protein , putative 0.0014 0.0108 0.1002
Echinococcus multilocularis mitogen activated protein kinase 3 0.0012 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0032 0.0499 0.1075
Brugia malayi hypothetical protein 0.0012 0.0074 0.016
Brugia malayi Intermediate filament tail domain containing protein 0.0015 0.0128 0.0277
Onchocerca volvulus Huntingtin homolog 0.0054 0.0955 0.2059
Onchocerca volvulus 0.0012 0.0074 0.016
Leishmania major dihydrofolate reductase-thymidylate synthase 0.006 0.1077 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0035 0.0543 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0074 0.0418
Brugia malayi Dihydrofolate reductase 0.0017 0.0181 0.039
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0012 0.0074 0.0418
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0137 0.269 0.269
Echinococcus granulosus lamin 0.0015 0.0128 0.0128
Mycobacterium tuberculosis Conserved protein 0.002 0.0233 0.0233
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0092 0.1752 0.1752
Brugia malayi hypothetical protein 0.0014 0.0108 0.0233
Trichomonas vaginalis myo inositol monophosphatase, putative 0.002 0.0244 0.044
Onchocerca volvulus Matrilysin homolog 0.0067 0.1235 0.2662
Mycobacterium ulcerans hypothetical protein 0.0044 0.0748 0.0748
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0074 0.0074
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0233 0.2165
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0696 0.1255
Toxoplasma gondii thioredoxin reductase 0.0021 0.0255 0.237
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Loa Loa (eye worm) hypothetical protein 0.0054 0.0955 0.2059
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.002 0.0242 0.2247
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0053 0.0931 0.0931
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0092 0.1752 0.1752
Schistosoma mansoni amine GPCR 0.0012 0.0074 0.0418
Loa Loa (eye worm) hypothetical protein 0.003 0.0455 0.0982
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0043 0.0712 0.3998
Brugia malayi G protein-coupled receptor 0.0012 0.0074 0.016
Mycobacterium tuberculosis Probable conserved lipoprotein 0.002 0.0233 0.0233
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Echinococcus multilocularis G protein coupled receptor 139 0.0012 0.0074 0.0074
Trichomonas vaginalis aldehyde oxidase, putative 0.0272 0.555 1
Schistosoma mansoni amine GPCR 0.0012 0.0074 0.0418
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0092 0.1752 0.1752
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0074 0.0074
Onchocerca volvulus 0.003 0.0455 0.0982
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0012 0.0074 0.016
Schistosoma mansoni dihydrofolate reductase 0.0017 0.0181 0.1017
Mycobacterium ulcerans DNA-methyltransferase (modification methylase) 0.001 0.0036 0.0036
Brugia malayi follicle stimulating hormone receptor 0.0139 0.2742 0.5912
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.0128 0.2519 0.2519
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Loa Loa (eye worm) thymidylate synthase 0.0043 0.0712 0.1535
Brugia malayi ORL1-like opioid receptor 0.0012 0.0074 0.016
Brugia malayi hypothetical protein 0.0014 0.0102 0.022
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0012 0.0074 0.0418
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0074 0.0074
Loa Loa (eye worm) matrixin family protein 0.0073 0.1363 0.2938
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0012 0.0074 0.0074
Echinococcus granulosus allatostatin A receptor 0.0012 0.0074 0.0074
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0074 0.0418
Schistosoma mansoni opsin-like receptor 0.0012 0.0074 0.0418
Echinococcus multilocularis allatostatin A receptor 0.0012 0.0074 0.0074
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0042 0.0696 0.6462
Treponema pallidum methylated-DNA-protein-cysteine S-methyltransferase (dat) 0.0026 0.0358 0.4282
Echinococcus granulosus mitogen activated protein kinase 3 0.0012 0.0063 0.0063
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0139 0.2742 0.5912
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0074 0.0074
Echinococcus granulosus neuropeptide receptor A26 0.0012 0.0074 0.0074
Brugia malayi Probable ClpP-like protease 0.0035 0.0543 0.117
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0021 0.0255 0.0255
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Onchocerca volvulus 0.0012 0.0074 0.016
Mycobacterium ulcerans aldehyde dehydrogenase 0.0033 0.052 0.052
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0074 0.0074
Trypanosoma cruzi PAB1-binding protein , putative 0.0014 0.0108 0.1002
Echinococcus granulosus dro:myosuppressin receptor 0.0012 0.0074 0.0074
Loa Loa (eye worm) pax transcription factor protein 2 0.0229 0.4638 1
Mycobacterium ulcerans hypothetical protein 0.002 0.0233 0.0233
Echinococcus granulosus 7TM GPCR rhodopsin 0.0012 0.0074 0.0074
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0012 0.0063 0.0582
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0047 0.0815 0.1756
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0074 0.0418
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0012 0.0074 0.016
Brugia malayi MAP kinase sur-1 0.0012 0.0063 0.0135
Onchocerca volvulus 0.0012 0.0074 0.016
Brugia malayi putative neuropeptide receptor NPR1 0.0012 0.0074 0.016
Echinococcus granulosus GPCR family 2 0.0015 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Echinococcus granulosus peptidase Clp S14 family 0.0023 0.0292 0.0292
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0015 0.0128 0.0277
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0074 0.0418
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0012 0.0063 0.0582
Treponema pallidum quinoline 2-oxidoreductase 0.0043 0.0726 0.9682
Schistosoma mansoni biogenic amine receptor 0.0012 0.0074 0.0418
Onchocerca volvulus 0.0012 0.0074 0.016
Trichomonas vaginalis D-aminoacylase, putative 0.002 0.0233 0.042
Schistosoma mansoni hypothetical protein 0.0093 0.1781 1
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.006 0.1077 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0074 0.0074
Schistosoma mansoni hypothetical protein 0.0012 0.0074 0.0418
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.002 0.0233 0.0503
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.003 0.0455 0.2558
Brugia malayi neuropeptide F receptor 0.0012 0.0074 0.016
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0035 0.0543 1
Leishmania major hypothetical protein, conserved 0.002 0.0233 0.2165
Loa Loa (eye worm) hypothetical protein 0.002 0.0233 0.0503
Mycobacterium tuberculosis Probable esterase LipL 0.002 0.0233 0.0233
Mycobacterium tuberculosis Probable hydrolase 0.002 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Onchocerca volvulus 0.0229 0.4638 1
Echinococcus granulosus g protein coupled receptor 0.0012 0.0074 0.0074
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0012 0.0074 0.0074
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0012 0.0066 0.0614
Schistosoma mansoni neuropeptide receptor 0.0012 0.0074 0.0418
Brugia malayi Pax transcription factor protein 2 0.0229 0.4638 1
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0074 0.0074
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0074 0.0418
Onchocerca volvulus Serine\/threonine kinase homolog 0.0042 0.0696 0.1501
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0023 0.0292 0.0292
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0012 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.013 0.2558 0.5515
Onchocerca volvulus 0.0012 0.0074 0.016
Echinococcus granulosus G protein coupled receptor 139 0.0012 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0074 0.0074
Brugia malayi MH2 domain containing protein 0.0053 0.0926 0.1996
Schistosoma mansoni neuropeptide receptor 0.0012 0.0074 0.0418
Onchocerca volvulus Huntingtin homolog 0.0054 0.0955 0.2059
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0127 0.2483 0.2483
Schistosoma mansoni biogenic amine receptor 0.0012 0.0074 0.0418
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0017 0.0181 0.0438
Schistosoma mansoni survival motor neuron protein 0.0027 0.0375 0.2106
Echinococcus multilocularis thymidylate synthase 0.0043 0.0712 0.0712
Loa Loa (eye worm) MH2 domain-containing protein 0.0053 0.0926 0.1996
Brugia malayi Melatonin receptor type 1A 0.0012 0.0074 0.016
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.018 0.3614 0.3614
Loa Loa (eye worm) hypothetical protein 0.0047 0.0815 0.1756
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0048 0.0819 0.0819
Brugia malayi Matrixin family protein 0.0073 0.1363 0.2938
Onchocerca volvulus 0.0012 0.0074 0.016
Echinococcus multilocularis thioredoxin glutathione reductase 0.0021 0.0255 0.0255
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0017 0.018 0.018
Echinococcus granulosus survival motor neuron protein 1 0.013 0.2558 0.2558
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Trichomonas vaginalis CMGC family protein kinase 0.0012 0.0063 0.0113
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0035 0.0543 0.0543
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0012 0.0074 0.0418
Schistosoma mansoni transcription factor LCR-F1 0.0014 0.0102 0.0574
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0074 0.0074
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.002 0.0244 0.4495
Loa Loa (eye worm) hypothetical protein 0.002 0.0233 0.0503
Brugia malayi thymidylate synthase 0.0043 0.0712 0.1535
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0017 0.018 0.101
Echinococcus granulosus orexin receptor type 2 0.0012 0.0074 0.0074
Mycobacterium tuberculosis Conserved protein 0.002 0.0233 0.0233
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0012 0.0074 0.016
Loa Loa (eye worm) hypothetical protein 0.0014 0.0108 0.0233
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0012 0.0074 0.0418
Brugia malayi G protein-coupled receptor F59B2.13 0.0012 0.0074 0.016
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0074 0.0074
Brugia malayi beta-lactamase family protein 0.002 0.0233 0.0503
Loa Loa (eye worm) glutathione reductase 0.0021 0.0255 0.0551
Mycobacterium tuberculosis Probable oxidoreductase 0.0053 0.0931 0.0931
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0012 0.0074 0.0074
Mycobacterium leprae Probable lipase LipE 0.002 0.0233 0.0636
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0137 0.269 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.002 0.0244 0.2265
Schistosoma mansoni hypothetical protein 0.0012 0.0074 0.0418
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0074 0.0418
Echinococcus granulosus peptide allatostatin:somatostatin 0.0012 0.0074 0.0074
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.0128 0.2519 0.2519
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0048 0.0819 0.0819
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0014 0.0102 0.0102
Echinococcus granulosus geminin 0.0093 0.1781 0.1781
Brugia malayi dihydrofolate reductase family protein 0.0017 0.0181 0.039
Onchocerca volvulus 0.002 0.0233 0.0503
Onchocerca volvulus 0.002 0.0233 0.0503
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0033 0.052 0.052
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0014 0.0102 0.0102
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0052 0.091 0.091
Mycobacterium ulcerans esterase/lipase LipP 0.002 0.0233 0.0233
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0074 0.0074
Echinococcus granulosus neuropeptide receptor 0.0012 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Mycobacterium ulcerans hydrolase 0.0037 0.0595 0.0595
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0012 0.0074 0.0074
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0063 0.0352
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0696 0.1255
Schistosoma mansoni intermediate filament proteins 0.0015 0.0128 0.0721
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0074 0.0074
Plasmodium falciparum ataxin-2 like protein, putative 0.0014 0.0108 0.1002
Brugia malayi hypothetical protein 0.0012 0.0074 0.016
Brugia malayi hypothetical protein 0.0012 0.0074 0.016
Onchocerca volvulus 0.0012 0.0074 0.016
Brugia malayi G-protein coupled receptor 0.0012 0.0074 0.016
Mycobacterium ulcerans lipase LipD 0.002 0.0233 0.0233
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0233 0.2165
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Echinococcus granulosus tumor protein p63 0.0149 0.2958 0.2958
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0696 0.1255
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.016
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0074 0.0074
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0132 0.0284

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 10.1 ug ml-1 Inhibitory activity against Candida albicans (40 clinical isolates), determined at pH-7.2 ChEMBL. 7473549
MIC (functional) = 10.1 ug ml-1 Inhibitory activity against Candida albicans (40 clinical isolates), determined at pH-7.2 ChEMBL. 7473549
MIC (functional) = 11.22 ug ml-1 Inhibitory activity against Candida albicans (40 clinical isolates), determined at pH-5.8 ChEMBL. 7473549
MIC (functional) = 11.22 ug ml-1 Inhibitory activity against Candida albicans (40 clinical isolates), determined at pH-5.8 ChEMBL. 7473549
MIC (functional) = 16.6 ug ml-1 Inhibitory activity against Candida. species. (40 clinical isolates), determined at pH-5.8 ChEMBL. 7473549
MIC (functional) = 29 ug ml-1 Inhibitory activity against Candida. species. (40 clinical isolates), determined at pH-7.2 ChEMBL. 7473549
MIC50 (functional) = 1 ug ml-1 50% inhibitory activity against Candida albicans (40 clinical isolates) determined at pH-7.2 ChEMBL. 7473549
MIC50 (functional) = 1 ug ml-1 50% inhibitory activity against Candida albicans (40 clinical isolates) determined at pH-7.2 ChEMBL. 7473549
MIC50 (functional) = 4 ug ml-1 50% inhibitory activity against Candida albicans (40 clinical isolates) determined at pH-5.8 ChEMBL. 7473549
MIC50 (functional) = 4 ug ml-1 50% inhibitory activity against Candida albicans (40 clinical isolates) determined at pH-5.8 ChEMBL. 7473549
MIC50 (functional) = 8 ug ml-1 Inhibitory activity against Candida .species (40 clinical isolates), determined at pH-5.8 ChEMBL. 7473549
MIC50 (functional) = 16 ug ml-1 50% inhibitory activity against the Candida. species (40 clinical isolates) was determined at pH-7.2 ChEMBL. 7473549
MIC90 (functional) = 16 ug ml-1 Inhibitory activity against the Candida albicans (40 clinical isolates), determined at pH-7.2 ChEMBL. 7473549
MIC90 (functional) = 16 ug ml-1 Inhibitory activity against the Candida albicans (40 clinical isolates), determined at pH-5.8 ChEMBL. 7473549
MIC90 (functional) = 16 ug ml-1 Inhibitory activity against the Candida albicans (40 clinical isolates), determined at pH-7.2 ChEMBL. 7473549
MIC90 (functional) = 16 ug ml-1 Inhibitory activity against the Candida albicans (40 clinical isolates), determined at pH-5.8 ChEMBL. 7473549
MIC90 (functional) = 32 ug ml-1 90% inhibitory activity against Candida. species (40 clinical isolates) determined at pH-7.2 ChEMBL. 7473549
MIC90 (functional) = 32 ug ml-1 Inhibitory activity against Candida .species (40 clinical isolates), determined at pH-5.8 ChEMBL. 7473549
R (functional) = 0 % Resistance against Candida. albicans (40 clinical isolates) at 256 microg/mL (pH=7.2), activity is expressed as R%. ChEMBL. 7473549
R (functional) = 0 % Percent resistance against all Candida. species (40 clinical isolates) at 256 micro g/mL (pH=7.2), activity is expressed as R%. ChEMBL. 7473549
R (functional) = 0 % Percent resistance against Candida albicans (40 clinical isolates) at 256 micro g/mL (pH=5.8), activity is expressed as R%. ChEMBL. 7473549
R (functional) = 0 % Resistance against all Candida. species (40 clinical isolates) at 256 micro g/mL (pH=5.8). Activity is expressed as R%. ChEMBL. 7473549
R (functional) = 0 % Resistance against Candida. albicans (40 clinical isolates) at 256 microg/mL (pH=7.2), activity is expressed as R%. ChEMBL. 7473549
R (functional) = 0 % Percent resistance against Candida albicans (40 clinical isolates) at 256 micro g/mL (pH=5.8), activity is expressed as R%. ChEMBL. 7473549

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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