Detailed information for compound 245697

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 326.171 | Formula: C11H19IO3
  • H donors: 0 H acceptors: 0 LogP: 2.98 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: ICC1(C)OOC2(C[C@@H]1CC[C@@H]2C)OC
  • InChi: 1S/C11H19IO3/c1-8-4-5-9-6-11(8,13-3)15-14-10(9,2)7-12/h8-9H,4-7H2,1-3H3/t8-,9-,10?,11?/m0/s1
  • InChiKey: LVSKPZQYWLVRST-SAAXCQNUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni serine/threonine-protein kinase 0.000916473 0.00187722 0.00206951
Onchocerca volvulus 0.0213438 0.100209 1
Trypanosoma cruzi cdc2-related kinase 1 0.00242873 0.00915678 0.0162856
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.00202679 0.00722196 0.0150727
Echinococcus multilocularis voltage dependent calcium channel 0.00202679 0.00722196 0.0150727
Schistosoma mansoni voltage-gated potassium channel 0.00202679 0.00722196 0.00864376
Echinococcus granulosus cyclic nucleotide gated cation channel 0.00202679 0.00722196 0.0150727
Echinococcus multilocularis voltage gated potassium channel 0.00202679 0.00722196 0.0150727
Echinococcus granulosus potassium voltage gated channel protein 0.00202679 0.00722196 0.0150727
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.00213598 0.00774757 0.280752
Trichomonas vaginalis PIKK family atypical protein kinase 0.00210723 0.0076092 0.0741342
Trypanosoma brucei cyclin 2 0.00198381 0.00701506 0.0123937
Schistosoma mansoni phospholipase C beta 0.000999289 0.00227587 0.00255987
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.00276614 0.010781 0.105848
Loa Loa (eye worm) hypothetical protein 0.000563712 0.000179128 0.0002816
Brugia malayi cation channel family protein 0.208266 1 1
Echinococcus granulosus potassium voltage gated channel protein 0.00202679 0.00722196 0.0150727
Leishmania major hypothetical protein, conserved 0.000566957 0.000194749 0.000041852
Toxoplasma gondii thioredoxin reductase 0.00616391 0.0271369 1
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.00202679 0.00722196 0.0070441
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.000566957 0.000194749 0.0000156241
Loa Loa (eye worm) hypothetical protein 0.00202679 0.00722196 0.0113534
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.00202679 0.00722196 0.0150727
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.114887 0.550499 1
Echinococcus multilocularis GPCR, family 3, C terminal 0.000797966 0.00130676 0.00238515
Schistosoma mansoni two-pore calcium channel 0.00202679 0.00722196 0.00864376
Trichomonas vaginalis mannosyltransferase 1, putative 0.0213438 0.100209 1
Echinococcus multilocularis transient receptor potential cation channel 0.00202679 0.00722196 0.0150727
Trichomonas vaginalis PIKK family atypical protein kinase 0.00224291 0.00826228 0.0806641
Brugia malayi Receptor family ligand binding region containing protein 0.00126024 0.003532 0.00335347
Echinococcus granulosus TRP transient receptor potential channel 0.00202679 0.00722196 0.0150727
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.000863858 0.00162394 0.0535956
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.00202679 0.00722196 0.0150727
Echinococcus multilocularis sodium channel protein 0.00202679 0.00722196 0.0150727
Entamoeba histolytica protein kinase, putative 0.00403605 0.0168939 0.166969
Brugia malayi glutathione reductase 0.00616391 0.0271369 0.0269626
Echinococcus multilocularis transient receptor potential cation channel 0.00202679 0.00722196 0.0150727
Echinococcus granulosus voltage gated potassium channel 0.00202679 0.00722196 0.0150727
Schistosoma mansoni metabotropic glutamate receptor 0.00411841 0.0172904 0.0210284
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.00202679 0.00722196 0.00864376
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.00213598 0.00774757 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.00105749 0.00255605 0.0236097
Toxoplasma gondii hypothetical protein 0.00202679 0.00722196 0.260826
Echinococcus multilocularis conserved hypothetical protein 0.00202679 0.00722196 0.0150727
Plasmodium falciparum thioredoxin reductase 0.00213598 0.00774757 0.280752
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.00213598 0.00774757 0.280335
Echinococcus granulosus serine protein kinase ATM 0.000587368 0.000293001 0.000210739
Schistosoma mansoni serine/threonine protein kinase 0.00242873 0.00915678 0.0110237
Giardia lamblia Kinase, AGC PKA 0.000863858 0.00162394 0.135005
Loa Loa (eye worm) hypothetical protein 0.00202679 0.00722196 0.0113534
Trichomonas vaginalis PIKK family atypical protein kinase 0.00210723 0.0076092 0.0741342
Schistosoma mansoni voltage-gated potassium channel 0.00202679 0.00722196 0.00864376
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.00202679 0.00722196 0.0150727
Plasmodium vivax glutathione reductase, putative 0.00616391 0.0271369 1
Echinococcus multilocularis two pore calcium channel protein 2 0.00202679 0.00722196 0.0150727
Brugia malayi cell division control protein 2 homolog 0.00242873 0.00915678 0.00897926
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.00202679 0.00722196 0.260826
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.00223964 0.00824659 0.021614
Echinococcus granulosus voltage dependent calcium channel 0.00202679 0.00722196 0.0150727
Plasmodium vivax protein kinase Crk2 0.00242873 0.00915678 0.333026
Trypanosoma cruzi inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.010692 0.0489339 0.0885677
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0411238 0.195424 0.354766
Schistosoma mansoni inositol 145-trisphosphate receptor 0.110846 0.531048 0.652972
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.00276614 0.010781 0.0192371
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.00242873 0.00915678 0.014395
Loa Loa (eye worm) hypothetical protein 0.00126024 0.003532 0.00555252
Plasmodium falciparum glutathione reductase 0.00213598 0.00774757 0.280752
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.00276614 0.010781 0.0227065
Onchocerca volvulus 0.00172756 0.00578156 0.0558603
Loa Loa (eye worm) hypothetical protein 0.000587368 0.000293001 0.000460615
Schistosoma mansoni voltage-gated potassium channel 0.00202679 0.00722196 0.00864376
Trichomonas vaginalis PIKK family atypical protein kinase 0.00163711 0.00534615 0.0515068
Leishmania major hypothetical protein, conserved 0.0781029 0.373431 1
Echinococcus multilocularis potassium voltage gated channel protein 0.00202679 0.00722196 0.0150727
Echinococcus multilocularis voltage gated hydrogen channel 1 0.00202679 0.00722196 0.0150727
Schistosoma mansoni hypothetical protein 0.00202679 0.00722196 0.00864376
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.00213598 0.00774757 0.0137248
Loa Loa (eye worm) hypothetical protein 0.00202679 0.00722196 0.0113534
Echinococcus multilocularis hyperpolarization activated cyclic 0.00202679 0.00722196 0.0150727
Echinococcus multilocularis rac serine:threonine kinase 0.000916473 0.00187722 0.00360873
Trichomonas vaginalis PIKK family atypical protein kinase 0.00158399 0.00509047 0.0489504
Brugia malayi phosphoinositide-dependent protein kinase I 0.00403605 0.0168939 0.0167178
Schistosoma mansoni inositol 145-trisphosphate receptor 0.169455 0.813176 1
Echinococcus granulosus transient receptor potential cation channel 0.00202679 0.00722196 0.0150727
Echinococcus granulosus thioredoxin glutathione reductase 0.00616391 0.0271369 0.0577882
Trichomonas vaginalis CMGC family protein kinase 0.00242873 0.00915678 0.0896077
Brugia malayi Protein kinase domain containing protein 0.00242873 0.00915678 0.00897926
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.000566957 0.000194749 0.000306158
Schistosoma mansoni transient receptor potential channel 4 0.00202679 0.00722196 0.00864376
Loa Loa (eye worm) hypothetical protein 0.00202679 0.00722196 0.0113534
Echinococcus granulosus hyperpolarization activated cyclic 0.00202679 0.00722196 0.0150727
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.00202679 0.00722196 0.0070441
Plasmodium falciparum protein kinase 5 0.00242873 0.00915678 0.333026
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0411238 0.195424 0.195279
Loa Loa (eye worm) Plcb4 protein 0.000999289 0.00227587 0.00357781
Loa Loa (eye worm) voltage-gated calcium channel 0.00202679 0.00722196 0.0113534
Brugia malayi phospholipase C homolog 0.000666719 0.000674976 0.000495937
Echinococcus multilocularis ryanodine receptor 44f 0.0755949 0.361358 0.774658
Leishmania major phosphoinositide-specific phospholipase C, putative 0.00126409 0.00355053 0.00903252
Echinococcus multilocularis thioredoxin glutathione reductase 0.00616391 0.0271369 0.0577882
Loa Loa (eye worm) hypothetical protein 0.00202679 0.00722196 0.0113534
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.00202679 0.00722196 0.0150727
Echinococcus granulosus potassium large conductance calcium activated 0.00202679 0.00722196 0.0150727
Brugia malayi Transient-receptor-potential like protein 0.00202679 0.00722196 0.0070441
Schistosoma mansoni voltage-gated potassium channel 0.00202679 0.00722196 0.00864376
Echinococcus granulosus voltage dependent calcium channel 0.00202679 0.00722196 0.0150727
Loa Loa (eye worm) hypothetical protein 0.00202679 0.00722196 0.0113534
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.00202679 0.00722196 0.0150727
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.000566957 0.000194749 0.000041852
Loa Loa (eye worm) hypothetical protein 0.000647822 0.000584008 0.000918096
Leishmania major hypothetical protein, conserved 0.000566957 0.000194749 0.000041852
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.000566957 0.000194749 0.000041852
Echinococcus granulosus serine:threonine protein kinase SMG1 0.000587368 0.000293001 0.000210739
Echinococcus granulosus transient receptor potential cation channel 0.00202679 0.00722196 0.0150727
Loa Loa (eye worm) hypothetical protein 0.00202679 0.00722196 0.0113534
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.000591608 0.000313412 0.00440434
Entamoeba histolytica protein kinase rad3, putative 0.000587368 0.000293001 0.000982375
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.00202679 0.00722196 0.0150727
Schistosoma mansoni voltage-gated potassium channel 0.00202679 0.00722196 0.00864376
Leishmania major calcium channel protein, putative,ion transporter, putative 0.00202679 0.00722196 0.0188689
Loa Loa (eye worm) variant SH3 domain-containing protein 0.000644223 0.000566687 0.000890866
Echinococcus granulosus potassium voltage gated channel subfamily H 0.00202679 0.00722196 0.0150727
Echinococcus granulosus metabotropic glutamate receptor 2 0.00411841 0.0172904 0.0366684
Trichomonas vaginalis PIKK family atypical protein kinase 0.00276614 0.010781 0.105848
Trypanosoma brucei cdc2-related kinase 1 0.00242873 0.00915678 0.0162856
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.00276614 0.010781 0.0106038
Echinococcus granulosus cyclin dependent kinase 5 0.00242873 0.00915678 0.0192226
Entamoeba histolytica PH domain containing protein kinase, putative 0.000916473 0.00187722 0.0168224
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.00202679 0.00722196 0.0150727
Echinococcus granulosus serine/threonine protein kinase 0.000916473 0.00187722 0.00360873
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.00202679 0.00722196 0.00864376
Plasmodium vivax ferrodoxin reductase, putative 0.000566957 0.000194749 0.000579474
Brugia malayi Thioredoxin reductase 0.00616391 0.0271369 0.0269626
Loa Loa (eye worm) hypothetical protein 0.0211166 0.0991148 0.155815
Trichomonas vaginalis PIKK family atypical protein kinase 0.00163711 0.00534615 0.0515068
Trichomonas vaginalis PIKK family atypical protein kinase 0.00171641 0.00572786 0.0553234
Entamoeba histolytica protein kinase 2, putative 0.000863858 0.00162394 0.01429
Trichomonas vaginalis AGC family protein kinase 0.00132509 0.00384416 0.0364891
Loa Loa (eye worm) hypothetical protein 0.010692 0.0489339 0.0769271
Trichomonas vaginalis PIKK family atypical protein kinase 0.00158073 0.00507478 0.0487935
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.00202679 0.00722196 0.0070441
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.00242873 0.00915678 0.0192226
Brugia malayi cation channel family protein 0.00202679 0.00722196 0.0070441
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.00559019 0.0243752 0.0297429
Trichomonas vaginalis PIKK family atypical protein kinase 0.00229602 0.00851797 0.0832205
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.000999289 0.00227587 0.00209712
Echinococcus multilocularis shaker cognate 0.00202679 0.00722196 0.0150727
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.136231 0.653242 0.65318
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.00129198 0.00368481 0.00634207
Loa Loa (eye worm) hypothetical protein 0.130163 0.624035 0.981021
Toxoplasma gondii transporter, cation channel family protein 0.00202679 0.00722196 0.260826
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.00202679 0.00722196 0.00864376
Schistosoma mansoni voltage-dependent calcium channel 0.00202679 0.00722196 0.00864376
Toxoplasma gondii FATC domain-containing protein 0.000587368 0.000293001 0.00364675
Trypanosoma brucei rac serine-threonine kinase, putative 0.00132509 0.00384416 0.00663163
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.00202679 0.00722196 0.00864376
Echinococcus multilocularis cyclin dependent kinase 0.00242873 0.00915678 0.0192226
Schistosoma mansoni voltage-gated potassium channel 0.00202679 0.00722196 0.00864376
Echinococcus granulosus serine threonine protein kinase nrc 0.000863858 0.00162394 0.00306548
Brugia malayi Metabotropic glutamate receptor precursor. 0.00491637 0.0211316 0.0209562
Echinococcus granulosus short transient receptor potential channel 6 0.00202679 0.00722196 0.0150727
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.00213598 0.00774757 1
Entamoeba histolytica MIR domain protein 0.0213438 0.100209 1
Schistosoma mansoni ryanodine receptor 1 skeletal muscle 0.0367841 0.174534 0.214444
Loa Loa (eye worm) hypothetical protein 0.00202679 0.00722196 0.0113534
Trypanosoma brucei cdc2-related kinase 3 0.00242873 0.00915678 0.0162856
Entamoeba histolytica protein kinase, putative 0.00127247 0.00359089 0.0339567
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.00403605 0.0168939 0.0265583
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.00202679 0.00722196 0.0113534
Loa Loa (eye worm) voltage-gated potassium channel 0.00202679 0.00722196 0.0113534
Loa Loa (eye worm) MIR domain-containing protein 0.0213438 0.100209 0.157534
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.00403605 0.0168939 0.0265583
Trichomonas vaginalis conserved hypothetical protein 0.00198381 0.00701506 0.0681936
Echinococcus granulosus nervana 2 0.000801042 0.00132157 0.00241691
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.00213598 0.00774757 0.280335
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.000587368 0.000293001 0.000982375
Echinococcus granulosus ryanodine receptor 44f 0.0755949 0.361358 0.774658
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.000587368 0.000293001 0.00017854
Echinococcus multilocularis Glutaredoxin protein 5 0.000801042 0.00132157 0.00241691
Echinococcus granulosus short transient receptor potential channel 6 0.00202679 0.00722196 0.0150727
Brugia malayi metabotropic GABA-B receptor subtype 2 0.000797966 0.00130676 0.00112784
Echinococcus multilocularis potassium large conductance calcium activated 0.00202679 0.00722196 0.0150727
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.00213598 0.00774757 0.020277
Echinococcus granulosus potassium voltage gated channel protein 0.00202679 0.00722196 0.0150727
Entamoeba histolytica PH domain containing protein kinase, putative 0.000916473 0.00187722 0.0168224
Brugia malayi voltage-dependent calcium channel 0.00202679 0.00722196 0.0070441
Echinococcus granulosus sodium channel protein 0.00202679 0.00722196 0.0150727
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.00202679 0.00722196 0.0150727
Giardia lamblia NADH oxidase lateral transfer candidate 0.00213598 0.00774757 0.713455
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.00276614 0.010781 0.0192371
Onchocerca volvulus 0.00172756 0.00578156 0.0558603
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.00105749 0.00255605 0.00237735
Toxoplasma gondii transporter, cation channel family protein 0.00202679 0.00722196 0.260826
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.00616391 0.0271369 1
Echinococcus multilocularis stromal cell derived factor 2 0.0213438 0.100209 0.21452
Loa Loa (eye worm) hypothetical protein 0.00202679 0.00722196 0.0113534
Trichomonas vaginalis AGC family protein kinase 0.00132509 0.00384416 0.0364891
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.00105749 0.00255605 0.0042909
Trichomonas vaginalis PIKK family atypical protein kinase 0.00276614 0.010781 0.105848
Trypanosoma cruzi trypanothione reductase, putative 0.00616391 0.0271369 0.0489587
Echinococcus granulosus potassium voltage gated channel subfamily H 0.00202679 0.00722196 0.0150727
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.00202679 0.00722196 0.0150727
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.00202679 0.00722196 0.00864376
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.00242873 0.00915678 0.0240525
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.00202679 0.00722196 0.00864376
Trypanosoma cruzi cdc2-related kinase 1 0.00242873 0.00915678 0.0162856
Echinococcus multilocularis voltage gated potassium channel 0.00202679 0.00722196 0.0150727
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.00213598 0.00774757 1
Trichomonas vaginalis AGC family protein kinase 0.00132509 0.00384416 0.0364891
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.00213598 0.00774757 0.280335
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.00276614 0.010781 0.0192371
Echinococcus granulosus ryanodine receptor 44f 0.09742 0.466417 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.00202679 0.00722196 0.0070441
Loa Loa (eye worm) voltage-gated potassium channel 0.00202679 0.00722196 0.0113534
Schistosoma mansoni serine/threonine protein kinase 0.00403605 0.0168939 0.0205407
Brugia malayi hypothetical protein 0.00202679 0.00722196 0.0070441
Schistosoma mansoni voltage-gated potassium channel 0.00202679 0.00722196 0.00864376
Trichomonas vaginalis AGC family protein kinase 0.00403605 0.0168939 0.166969
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.00276614 0.010781 0.0284041
Loa Loa (eye worm) ryanodine receptor 0.0367841 0.174534 0.274377
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.000587368 0.000293001 0.00017854
Loa Loa (eye worm) hypothetical protein 0.00236591 0.0088544 0.0139196
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.00202679 0.00722196 0.00864376
Trypanosoma cruzi cdc2-related kinase 3 0.00242873 0.00915678 0.0162856
Schistosoma mansoni voltage-gated potassium channel 0.00202679 0.00722196 0.00864376
Loa Loa (eye worm) phosphatidylinositol 3 0.00276614 0.010781 0.0169484
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.00213598 0.00774757 0.0162
Echinococcus granulosus cyclin dependent kinase 1 0.00242873 0.00915678 0.0192226
Loa Loa (eye worm) voltage-dependent calcium channel 0.00202679 0.00722196 0.0113534
Schistosoma mansoni voltage-gated cation channel 0.00202679 0.00722196 0.00864376
Trichomonas vaginalis PIKK family atypical protein kinase 0.00210723 0.0076092 0.0741342
Leishmania major hypothetical protein, conserved 0.000566957 0.000194749 0.000041852
Trichomonas vaginalis PIKK family atypical protein kinase 0.00210723 0.0076092 0.0741342
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.00213598 0.00774757 0.00929028
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.00202679 0.00722196 0.0150727
Echinococcus multilocularis sodium leak channel non selective protein 0.00202679 0.00722196 0.0150727
Schistosoma mansoni fkbp-rapamycin associated protein 0.000587368 0.000293001 0.000120854
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.000566957 0.000194749 0.0000156241
Onchocerca volvulus Poor gastrulation protein homolog 0.000797966 0.00130676 0.0111186
Echinococcus multilocularis ryanodine receptor 44f 0.09742 0.466417 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.00213598 0.00774757 0.020277
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.00202679 0.00722196 0.0150727
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.00202679 0.00722196 0.0127697
Trichomonas vaginalis AGC family protein kinase 0.00132509 0.00384416 0.0364891
Leishmania major hypothetical protein, unknown function 0.00202679 0.00722196 0.0188689
Loa Loa (eye worm) hypothetical protein 0.00202679 0.00722196 0.0113534
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.00276614 0.010781 0.0130215
Brugia malayi Protein kinase domain containing protein 0.00132509 0.00384416 0.00366569
Loa Loa (eye worm) hypothetical protein 0.132671 0.636108 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.00105749 0.00255605 0.0042909
Toxoplasma gondii non-specific serine/threonine protein kinase 0.000647822 0.000584008 0.0144479
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.00213598 0.00774757 0.0137248
Trichomonas vaginalis PIKK family atypical protein kinase 0.000704197 0.00085538 0.00660538
Schistosoma mansoni voltage-gated potassium channel 0.00202679 0.00722196 0.00864376
Trypanosoma cruzi CYC2-like cyclin, putative 0.00198381 0.00701506 0.0123937
Echinococcus granulosus hyperpolarization activated cyclic 0.00202679 0.00722196 0.0150727
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.00202679 0.00722196 0.0150727
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.000666719 0.000674976 0.000590699
Treponema pallidum NADH oxidase 0.00213598 0.00774757 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.000587368 0.000293001 0.000113893
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.00127247 0.00359089 0.0056451
Trypanosoma cruzi trypanothione reductase, putative 0.00213598 0.00774757 0.0137248
Echinococcus multilocularis serine protein kinase ATM 0.000587368 0.000293001 0.000210739
Echinococcus multilocularis metabotropic glutamate receptor 2 0.00411841 0.0172904 0.0366684
Echinococcus granulosus metabotropic glutamate receptor 5 0.00605246 0.0266004 0.0566374
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.00213598 0.00774757 0.280752
Echinococcus granulosus GPCR family 3 C terminal 0.000797966 0.00130676 0.00238515
Loa Loa (eye worm) hypothetical protein 0.00202679 0.00722196 0.0113534
Trichomonas vaginalis PIKK family atypical protein kinase 0.00224291 0.00826228 0.0806641
Trichomonas vaginalis CMGC family protein kinase 0.00242873 0.00915678 0.0896077
Echinococcus granulosus voltage gated potassium channel 0.00202679 0.00722196 0.0150727
Trypanosoma cruzi rac serine-threonine kinase, putative 0.000916473 0.00187722 0.00305735
Trypanosoma cruzi target of rapamycin kinase 3 0.00223964 0.00824659 0.0146316
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.00202679 0.00722196 0.0150727
Echinococcus multilocularis voltage dependent calcium channel 0.00202679 0.00722196 0.0150727
Echinococcus granulosus cyclin dependent kinase 0.00242873 0.00915678 0.0192226
Echinococcus granulosus transient receptor potential cation channel 0.00202679 0.00722196 0.0150727
Echinococcus granulosus calcium activated potassium channel 0.0020896 0.00752434 0.0157212
Trichomonas vaginalis PIKK family atypical protein kinase 0.00224291 0.00826228 0.0806641
Trichomonas vaginalis PIKK family atypical protein kinase 0.000587368 0.000293001 0.000982375
Echinococcus multilocularis transfer RNA-Gly 0.00202679 0.00722196 0.0150727
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.00213598 0.00774757 1
Trypanosoma brucei trypanothione reductase 0.00616391 0.0271369 0.0489587
Loa Loa (eye worm) programmed cell death 8 0.000566957 0.000194749 0.000306158
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.00202679 0.00722196 0.0702623
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.00198381 0.00701506 0.253146
Loa Loa (eye worm) hypothetical protein 0.00202679 0.00722196 0.0113534
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.00129198 0.00368481 0.00579275
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.00202679 0.00722196 0.0070441
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.00276614 0.010781 0.0284041
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.000587368 0.000293001 0.00017854
Loa Loa (eye worm) thioredoxin reductase 0.00616391 0.0271369 0.0426609
Echinococcus granulosus nervana 2 0.000801042 0.00132157 0.00241691
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.00202679 0.00722196 0.00864376
Trypanosoma brucei target of rapamycin kinase 3, putative 0.00223964 0.00824659 0.0146316
Trypanosoma cruzi Protein kinase B 0.000916473 0.00187722 0.00305735
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.00202679 0.00722196 0.00864376
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.000797966 0.00130676 0.0111186
Giardia lamblia Kinase, CMGC CDK 0.00242873 0.00915678 0.846571
Loa Loa (eye worm) hypothetical protein 0.00202679 0.00722196 0.0113534
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.00202679 0.00722196 0.0702623
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.00202679 0.00722196 0.00864376
Echinococcus multilocularis transient receptor potential cation channel 0.00202679 0.00722196 0.0150727
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.00213598 0.00774757 0.280752
Trichomonas vaginalis PIKK family atypical protein kinase 0.00105749 0.00255605 0.0236097
Trichomonas vaginalis AGC family protein kinase 0.00403605 0.0168939 0.166969
Trichomonas vaginalis PIKK family atypical protein kinase 0.00210723 0.0076092 0.0741342
Trichomonas vaginalis AGC family protein kinase 0.00132509 0.00384416 0.0364891
Loa Loa (eye worm) hypothetical protein 0.0411238 0.195424 0.307218
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.00202679 0.00722196 0.0070441
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.00213598 0.00774757 0.0137248
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.00105749 0.00255605 0.00506475
Trichomonas vaginalis CMGC family protein kinase 0.00242873 0.00915678 0.0896077
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.00202679 0.00722196 0.0070441
Echinococcus granulosus hypothetical protein 0.00202679 0.00722196 0.0150727
Echinococcus multilocularis transient receptor potential gamma protein 0.00202679 0.00722196 0.0150727
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.00202679 0.00722196 0.0150727
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.00213598 0.00774757 0.0137248
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.000566957 0.000194749 0.000579474
Brugia malayi Variant SH3 domain containing protein 0.000644223 0.000566687 0.000387628
Loa Loa (eye worm) hypothetical protein 0.00102719 0.00241016 0.00378891
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.00202679 0.00722196 0.0702623
Schistosoma mansoni serine/threonine-protein kinase 0.000916473 0.00187722 0.00206951
Trichomonas vaginalis PIKK family atypical protein kinase 0.00105749 0.00255605 0.0236097
Toxoplasma gondii cyclin2 related protein 0.00198381 0.00701506 0.253146
Schistosoma mansoni voltage-gated potassium channel 0.00202679 0.00722196 0.00864376
Trichomonas vaginalis PIKK family atypical protein kinase 0.00210723 0.0076092 0.0741342
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.00213598 0.00774757 0.0137248
Trichomonas vaginalis PIKK family atypical protein kinase 0.00183323 0.00629024 0.0609464
Echinococcus granulosus shaker cognate 0.00202679 0.00722196 0.0150727
Echinococcus granulosus sodium leak channel non selective protein 0.00202679 0.00722196 0.0150727
Leishmania major C-8 sterol isomerase-like protein 0.0411238 0.195424 0.523091
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.000801042 0.00132157 0.00241691
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.00122744 0.00337411 0.00577746
Plasmodium falciparum ferrodoxin reductase-like protein 0.000566957 0.000194749 0.000579474
Echinococcus multilocularis nervana 2 0.000801042 0.00132157 0.00241691
Leishmania major phospholipase c-like protein 0.00129198 0.00368481 0.00939228
Echinococcus granulosus potassium voltage gated channel subfamily A 0.00202679 0.00722196 0.0150727
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.00213598 0.00774757 0.0162
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.00242873 0.00915678 0.33264
Echinococcus granulosus potassium voltage gated channel subfamily D 0.00202679 0.00722196 0.0150727
Echinococcus granulosus cyclic nucleotide gated cation channel 0.00202679 0.00722196 0.0150727
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.000566957 0.000194749 0.000579474
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.00202679 0.00722196 0.0127697
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.114887 0.550499 1
Schistosoma mansoni voltage-gated potassium channel 0.00202679 0.00722196 0.00864376
Trichomonas vaginalis PIKK family atypical protein kinase 0.00177278 0.00599923 0.0580367
Entamoeba histolytica hypothetical protein 0.000587368 0.000293001 0.000982375
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.000566957 0.000194749 0.000579474
Trichomonas vaginalis PIKK family atypical protein kinase 0.00276614 0.010781 0.105848
Echinococcus multilocularis short transient receptor potential channel 6 0.00202679 0.00722196 0.0150727
Trichomonas vaginalis PIKK family atypical protein kinase 0.000587368 0.000293001 0.000982375
Loa Loa (eye worm) hypothetical protein 0.00202679 0.00722196 0.0113534
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.00213598 0.00774757 0.0137248
Echinococcus granulosus Glutaredoxin protein 5 0.000801042 0.00132157 0.00241691
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.00202679 0.00722196 0.0113534
Trichomonas vaginalis AGC family protein kinase 0.00403605 0.0168939 0.166969
Echinococcus granulosus potassium voltage gated channel subfamily D 0.00202679 0.00722196 0.0150727
Toxoplasma gondii target of rapamycin (TOR), putative 0.00210723 0.0076092 0.275199
Trichomonas vaginalis PIKK family atypical protein kinase 0.00224291 0.00826228 0.0806641
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.000587368 0.000293001 0.000113893
Trichomonas vaginalis AGC family protein kinase 0.00132509 0.00384416 0.0364891
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0044541 0.0189064 0.0187306
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.00213598 0.00774757 0.0137248
Trypanosoma cruzi rac serine-threonine kinase, putative 0.000863858 0.00162394 0.0025971
Trypanosoma cruzi cdc2-related kinase 3 0.00242873 0.00915678 0.0162856
Echinococcus multilocularis calcium activated potassium channel 0.0020896 0.00752434 0.0157212
Plasmodium falciparum thioredoxin reductase 0.00616391 0.0271369 1
Loa Loa (eye worm) hypothetical protein 0.00605246 0.0266004 0.0418174
Echinococcus granulosus two pore calcium channel protein 1 0.00202679 0.00722196 0.0150727
Leishmania major dihydrolipoamide dehydrogenase, putative 0.00213598 0.00774757 0.020277
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.000863858 0.00162394 0.0535956
Schistosoma mansoni 60S ribosomal protein L21 0.00202679 0.00722196 0.00864376
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.00242873 0.00915678 0.014395
Plasmodium vivax thioredoxin reductase, putative 0.00616391 0.0271369 1
Leishmania major inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.010692 0.0489339 0.130622
Loa Loa (eye worm) ion channel NompC 0.00202679 0.00722196 0.0113534
Loa Loa (eye worm) hypothetical protein 0.00202679 0.00722196 0.0113534
Schistosoma mansoni voltage-gated potassium channel 0.00202679 0.00722196 0.00864376
Echinococcus multilocularis transient receptor potential cation channel 0.00202679 0.00722196 0.0150727
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.011075 0.0507776 0.0919181
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.00202679 0.00722196 0.0702623
Schistosoma mansoni ryanodine receptor related 0.136231 0.653242 0.803275
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.00202679 0.00722196 0.0150727
Loa Loa (eye worm) glutamate receptor 0.00491637 0.0211316 0.0332202
Trichomonas vaginalis PIKK family atypical protein kinase 0.000587368 0.000293001 0.000982375
Entamoeba histolytica cell division protein kinase 2, putative 0.00242873 0.00915678 0.0896077
Trichomonas vaginalis PIKK family atypical protein kinase 0.00158073 0.00507478 0.0487935
Leishmania major NADH dehydrogenase, putative 0.000566957 0.000194749 0.000041852
Loa Loa (eye worm) phosphatidylinositol 3 0.00105749 0.00255605 0.00401827
Echinococcus multilocularis nervana 2 0.000801042 0.00132157 0.00241691
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.000566957 0.000194749 0.0000156241
Loa Loa (eye worm) hypothetical protein 0.00102719 0.00241016 0.00378891
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.00202679 0.00722196 0.00864376
Schistosoma mansoni voltage-gated potassium channel 0.00202679 0.00722196 0.00864376
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.00202679 0.00722196 0.0150727
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.00276614 0.010781 0.0192371
Trypanosoma cruzi CYC2-like cyclin 6, putative 0.00198381 0.00701506 0.0123937
Echinococcus granulosus potassium voltage gated channel protein 0.00202679 0.00722196 0.0150727
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.00105749 0.00255605 0.0042909
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.00202679 0.00722196 0.00864376
Schistosoma mansoni serine/threonine protein kinase 0.00242873 0.00915678 0.0110237
Brugia malayi olfactory channel protein osm-9 0.00202679 0.00722196 0.0070441
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.00117106 0.00310274 0.00528433
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.00105749 0.00255605 0.00506475
Trypanosoma brucei CYC2-like cyclin, putative 0.00198381 0.00701506 0.0123937
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.00105749 0.00255605 0.0042909
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.000863858 0.00162394 0.00306548
Mycobacterium tuberculosis Probable oxidoreductase 0.00213598 0.00774757 0.280335
Schistosoma mansoni hypothetical protein 0.000797966 0.00130676 0.00136782
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.00403605 0.0168939 0.0358181
Trichomonas vaginalis PIKK family atypical protein kinase 0.00158073 0.00507478 0.0487935
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.00202679 0.00722196 0.260826
Loa Loa (eye worm) hypothetical protein 0.09742 0.466417 0.733237
Brugia malayi glutamate synthase 0.000566957 0.000194749 0.0000156241
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.00213598 0.00774757 0.0137248
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.00202679 0.00722196 0.0150727
Brugia malayi p70 ribosomal S6 kinase beta 0.00127247 0.00359089 0.00341237
Loa Loa (eye worm) hypothetical protein 0.110846 0.531048 0.83484
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.00202679 0.00722196 0.0070441
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.00202679 0.00722196 0.00864376
Trichomonas vaginalis PIKK family atypical protein kinase 0.00224291 0.00826228 0.0806641
Trichomonas vaginalis AGC family protein kinase 0.00132509 0.00384416 0.0364891
Plasmodium falciparum cyclin, putative 0.00198381 0.00701506 0.253579
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.000587368 0.000293001 0.000120853
Loa Loa (eye worm) hypothetical protein 0.000797966 0.00130676 0.00205431
Entamoeba histolytica protein kinase, putative 0.00132509 0.00384416 0.0364891
Echinococcus multilocularis hyperpolarization activated cyclic 0.00202679 0.00722196 0.0150727
Brugia malayi ion channel NompC 0.00202679 0.00722196 0.0070441
Echinococcus granulosus transient receptor potential cation channel 0.00202679 0.00722196 0.0150727
Schistosoma mansoni voltage-gated ion channel 0.00202679 0.00722196 0.00864376
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.00202679 0.00722196 0.00864376
Schistosoma mansoni voltage-gated potassium channel 0.00202679 0.00722196 0.00864376
Loa Loa (eye worm) hypothetical protein 0.00202679 0.00722196 0.0113534
Brugia malayi Cyclic-nucleotide gated cation channel 0.00202679 0.00722196 0.0070441
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.00213598 0.00774757 0.0137248
Trichomonas vaginalis glutathione reductase, putative 0.00213598 0.00774757 0.0755177
Loa Loa (eye worm) hypothetical protein 0.000566957 0.000194749 0.000306158
Schistosoma mansoni transient receptor potential channel 0.00202679 0.00722196 0.00864376
Loa Loa (eye worm) hypothetical protein 0.010692 0.0489339 0.0769271
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.00202679 0.00722196 0.0070441
Trypanosoma brucei C-8 sterol isomerase, putative 0.0411238 0.195424 0.354766
Echinococcus multilocularis short transient receptor potential channel 6 0.00202679 0.00722196 0.0150727
Leishmania major acetoin dehydrogenase e3 component-like protein 0.00213598 0.00774757 0.020277
Leishmania major phosphatidylinositol 3-kinase, putative 0.00105749 0.00255605 0.00636815
Echinococcus granulosus voltage gated hydrogen channel 1 0.00202679 0.00722196 0.0150727
Echinococcus multilocularis cyclin dependent kinase 1 0.00242873 0.00915678 0.0192226
Echinococcus granulosus transient receptor potential gamma protein 0.00202679 0.00722196 0.0150727
Trichomonas vaginalis conserved hypothetical protein 0.000647822 0.000584008 0.00389204
Brugia malayi MIR domain containing protein 0.0213438 0.100209 0.100047
Loa Loa (eye worm) hypothetical protein 0.00202679 0.00722196 0.0113534
Echinococcus multilocularis TRP (transient receptor potential) channel 0.00202679 0.00722196 0.0150727
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.00129198 0.00368481 0.00634207
Toxoplasma gondii NADPH-glutathione reductase 0.00213598 0.00774757 0.280335
Toxoplasma gondii AGC kinase 0.00127247 0.00359089 0.126053
Brugia malayi Protein kinase domain containing protein 0.00403605 0.0168939 0.0167178
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.00276614 0.010781 0.105848
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.00213598 0.00774757 0.0137248
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.000863858 0.00162394 0.00306548
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.00202679 0.00722196 0.0150727
Loa Loa (eye worm) hypothetical protein 0.00202679 0.00722196 0.0113534
Loa Loa (eye worm) hypothetical protein 0.00202679 0.00722196 0.0113534
Echinococcus multilocularis transient receptor potential cation channel 0.00202679 0.00722196 0.0150727
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.00403605 0.0168939 0.0358181
Toxoplasma gondii hypothetical protein 0.00202679 0.00722196 0.260826
Entamoeba histolytica protein kinase, putative 0.00132509 0.00384416 0.0364891
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.00213598 0.00774757 0.280752
Echinococcus multilocularis metabotropic glutamate receptor 5 0.00605246 0.0266004 0.0566374
Loa Loa (eye worm) calcium channel 0.00202679 0.00722196 0.0113534
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.00213598 0.00774757 0.280335
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.000587368 0.000293001 0.000210739
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.00213598 0.00774757 0.0137248
Schistosoma mansoni voltage-gated potassium channel 0.00202679 0.00722196 0.00864376
Leishmania major trypanothione reductase 0.00616391 0.0271369 0.0722241
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.00126024 0.003532 0.00555252
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.00202679 0.00722196 0.0150727
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.00126024 0.003532 0.00555252
Onchocerca volvulus 0.00202679 0.00722196 0.0702623
Schistosoma mansoni voltage-gated potassium channel 0.00202679 0.00722196 0.00864376
Schistosoma mansoni transient receptor potential channel 0.00202679 0.00722196 0.00864376
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.00276614 0.010781 0.0227065
Schistosoma mansoni voltage-gated potassium channel 0.00202679 0.00722196 0.00864376
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.00102719 0.00241016 0.00475182
Echinococcus granulosus transient receptor potential cation channel 0.00202679 0.00722196 0.0150727
Leishmania major CYC2-like cyclin, putative 0.00198381 0.00701506 0.0183145
Loa Loa (eye worm) glutathione reductase 0.00616391 0.0271369 0.0426609
Leishmania major phosphatidylinositol 3-related kinase, putative 0.00105749 0.00255605 0.00636815
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.00202679 0.00722196 0.00864376
Echinococcus multilocularis potassium voltage gated channel protein 0.00202679 0.00722196 0.0150727
Plasmodium falciparum glutathione reductase 0.00616391 0.0271369 1
Trypanosoma cruzi inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.010692 0.0489339 0.0885677
Entamoeba histolytica cell division protein kinase 2, putative 0.00242873 0.00915678 0.0896077
Echinococcus granulosus potassium voltage gated channel subfamily D 0.00202679 0.00722196 0.0150727
Loa Loa (eye worm) hypothetical protein 0.00202679 0.00722196 0.0113534
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.00102719 0.00241016 0.00475182
Giardia lamblia GTOR 0.00276614 0.010781 1
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.00242873 0.00915678 0.0240525
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.00202679 0.00722196 0.0150727
Loa Loa (eye worm) hypothetical protein 0.010692 0.0489339 0.0769271
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.00242873 0.00915678 0.014395
Brugia malayi metabotropic glutamate receptor type 2 0.00239632 0.0090008 0.00882325
Trichomonas vaginalis PIKK family atypical protein kinase 0.00171641 0.00572786 0.0553234
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.00202679 0.00722196 0.0113534
Trypanosoma cruzi CYC2-like cyclin 4, putative 0.00198381 0.00701506 0.0123937
Trichomonas vaginalis PIKK family atypical protein kinase 0.00105749 0.00255605 0.0236097
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.00129198 0.00368481 0.00350631
Toxoplasma gondii transporter, cation channel family protein 0.00202679 0.00722196 0.260826
Echinococcus multilocularis potassium voltage gated channel protein 0.00202679 0.00722196 0.0150727
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.00156902 0.0050184 0.00484014
Trichomonas vaginalis PIKK family atypical protein kinase 0.00210723 0.0076092 0.0741342
Trichomonas vaginalis PIKK family atypical protein kinase 0.00105749 0.00255605 0.0236097
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.00202679 0.00722196 0.00864376
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.00213598 0.00774757 0.0137248
Echinococcus multilocularis two pore calcium channel protein 1 0.00202679 0.00722196 0.0150727
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.00202679 0.00722196 0.0150727
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.00156902 0.0050184 0.00484014
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.000801042 0.00132157 0.00241691
Schistosoma mansoni voltage-gated potassium channel 0.00202679 0.00722196 0.00864376
Echinococcus granulosus potassium voltage gated channel protein 0.00202679 0.00722196 0.0150727
Echinococcus multilocularis potassium voltage gated channel protein 0.00202679 0.00722196 0.0150727
Echinococcus granulosus transient receptor potential cation channel 0.00202679 0.00722196 0.0150727
Trichomonas vaginalis PIKK family atypical protein kinase 0.00163711 0.00534615 0.0515068
Schistosoma mansoni calcium-activated potassium channel 0.00202679 0.00722196 0.00864376
Schistosoma mansoni vesicular amine transporter 0.00202679 0.00722196 0.00864376
Mycobacterium ulcerans flavoprotein disulfide reductase 0.00213598 0.00774757 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.00213598 0.00774757 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.00105749 0.00255605 0.0029045
Echinococcus granulosus stromal cell derived factor 2 0.0213438 0.100209 0.21452
Trichomonas vaginalis PIKK family atypical protein kinase 0.00158399 0.00509047 0.0489504
Echinococcus multilocularis cyclin dependent kinase 1 0.00242873 0.00915678 0.0192226
Plasmodium vivax cyclin, putative 0.00198381 0.00701506 0.253579
Loa Loa (eye worm) hypothetical protein 0.00202679 0.00722196 0.0113534
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.00202679 0.00722196 0.0070441
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.00213598 0.00774757 1
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.00202679 0.00722196 0.0070441
Echinococcus multilocularis transient receptor potential cation channel 0.00202679 0.00722196 0.0150727
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.00202679 0.00722196 0.0070441
Trichomonas vaginalis PIKK family atypical protein kinase 0.00158073 0.00507478 0.0487935
Schistosoma mansoni metabotropic glutamate receptor 0.00239632 0.0090008 0.0108318
Loa Loa (eye worm) glutamate receptor 0.00193405 0.00677556 0.0106516
Echinococcus granulosus potassium voltage gated channel subfamily C 0.00202679 0.00722196 0.0150727
Echinococcus multilocularis cyclin dependent kinase 5 0.00242873 0.00915678 0.0192226
Schistosoma mansoni stromal cell-derived factor 2 precursor-like protein 0.0213438 0.100209 0.123021
Trichomonas vaginalis mercuric reductase, putative 0.00213598 0.00774757 0.0755177
Loa Loa (eye worm) ryanodine receptor 0.00202679 0.00722196 0.0113534
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.000566957 0.000194749 0.000579474
Loa Loa (eye worm) AGC/AKT protein kinase 0.00132509 0.00384416 0.00604326
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.00213598 0.00774757 0.0075698
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.00202679 0.00722196 0.0070441
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.00202679 0.00722196 0.0150727
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.00202679 0.00722196 0.0070441
Echinococcus granulosus two pore calcium channel protein 2 0.00202679 0.00722196 0.0150727
Schistosoma mansoni transient receptor potential channel 0.00202679 0.00722196 0.00864376
Giardia lamblia Kinase, CMGC CDK 0.00242873 0.00915678 0.846571
Trichomonas vaginalis PIKK family atypical protein kinase 0.00158399 0.00509047 0.0489504

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 2 uM In vitro antimalarial activity against plasmodium falciparum ChEMBL. 12361400
EC50 (functional) = 2 uM In vitro antimalarial activity against plasmodium falciparum ChEMBL. 12361400
EC50 (ADMET) > 54 uM Effective concentration against mouse mammary FM3A cells ChEMBL. 12361400
EC50 (ADMET) > 54 uM Effective concentration against mouse mammary FM3A cells ChEMBL. 12361400
Inhibition (ADMET) = 8 % Percent inhibition of growth against mouse mammary FM3A cells ChEMBL. 12361400
Inhibition (ADMET) = 8 % Percent inhibition of growth against mouse mammary FM3A cells ChEMBL. 12361400
Selectivity (functional) > 27 Selectivity of the compound as the ratio of EC50 value for FM3A cells to that of P. falciparum. ChEMBL. 12361400

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 12361400

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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