Detailed information for compound 253930

Basic information

Technical information
  • TDR Targets ID: 253930
  • Name: 1-[(3,5-dihydroxyphenyl)methyl]-2,3-dioxoindo le-5-carboxamide
  • MW: 312.277 | Formula: C16H12N2O5
  • H donors: 3 H acceptors: 5 LogP: 0.56 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1cc(cc(c1)O)CN1c2ccc(cc2C(=O)C1=O)C(=O)N
  • InChi: 1S/C16H12N2O5/c17-15(22)9-1-2-13-12(5-9)14(21)16(23)18(13)7-8-3-10(19)6-11(20)4-8/h1-6,19-20H,7H2,(H2,17,22)
  • InChiKey: YRUPFXOYFDKGAN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[(3,5-dihydroxyphenyl)methyl]-2,3-dioxo-indoline-5-carboxamide
  • 1-[(3,5-dihydroxyphenyl)methyl]-2,3-dioxo-5-indolinecarboxamide
  • 1-[(3,5-dihydroxyphenyl)methyl]-2,3-dioxo-indole-5-carboxamide
  • 1-(3,5-dihydroxybenzyl)-2,3-diketo-indoline-5-carboxamide
  • AIDS-192615
  • AIDS192615
  • 1H-Indole-5-carboxamide, 1-[(3,5-dihydroxyphenyl)methyl]-2,3-dihydro-2,3-dioxo-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human rhinovirus sp. Human rhinovirus A protease Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii microneme protein, putative 0.0096 0.0865 0.0258
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.033 0.033
Brugia malayi EGF-like domain containing protein 0.0082 0.068 0.0861
Schistosoma mansoni hypothetical protein 0.0082 0.068 0.0861
Echinococcus multilocularis notch 0.0082 0.068 0.068
Loa Loa (eye worm) hypothetical protein 0.0113 0.1082 0.137
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0234 0.0296
Schistosoma mansoni slit 0.0082 0.068 0.0861
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0858 0.0858
Toxoplasma gondii PAN domain-containing protein 0.0096 0.0865 0.0258
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0113 0.1082 0.1371
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0281 0.0354
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0096 0.0865 0.0258
Loa Loa (eye worm) hypothetical protein 0.0115 0.1105 0.1398
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0113 0.1082 0.1371
Brugia malayi Calcium binding EGF domain containing protein 0.0115 0.1105 0.14
Echinococcus granulosus delta-like protein 1 0.0082 0.068 0.0861
Toxoplasma gondii hypothetical protein 0.0096 0.0865 0.0258
Onchocerca volvulus Huntingtin homolog 0.0119 0.1166 0.1241
Loa Loa (eye worm) hypothetical protein 0.0119 0.1166 0.1476
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0136 0.0173
Loa Loa (eye worm) hypothetical protein 0.0041 0.0136 0.0171
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0113 0.1082 0.1371
Loa Loa (eye worm) hypothetical protein 0.0048 0.0229 0.0288
Echinococcus granulosus neurogenic locus notch protein 4 0.0082 0.068 0.0861
Onchocerca volvulus Huntingtin homolog 0.0119 0.1166 0.1241
Toxoplasma gondii PAN domain-containing protein 0.0096 0.0865 0.0258
Toxoplasma gondii hypothetical protein 0.0096 0.0865 0.0258
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0113 0.1082 0.1082
Loa Loa (eye worm) trypsin family protein 0.0113 0.1082 0.137
Echinococcus granulosus tumor protein p63 0.0329 0.393 0.4979
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0858 0.1086
Schistosoma mansoni notch 0.0082 0.068 0.0861
Loa Loa (eye worm) hypothetical protein 0.0082 0.068 0.0859
Onchocerca volvulus 0.0096 0.0865 0.0849
Echinococcus multilocularis protein jagged 2 0.0082 0.068 0.068
Loa Loa (eye worm) hypothetical protein 0.0082 0.068 0.0859
Echinococcus multilocularis Tolloid protein 1 0.0115 0.1105 0.1105
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0301 0.3563 0.3563
Schistosoma mansoni hypothetical protein 0.0035 0.0056 0.0071
Schistosoma mansoni cercarial elastase (S01 family) 0.0113 0.1082 0.1371
Loa Loa (eye worm) hypothetical protein 0.0082 0.068 0.0859
Echinococcus multilocularis Mastin 0.0113 0.1082 0.1082
Schistosoma mansoni cell polarity protein 0.0082 0.068 0.0861
Brugia malayi PAN domain containing protein 0.0096 0.0865 0.1096
Loa Loa (eye worm) hypothetical protein 0.0082 0.068 0.0859
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.14 0.1773
Loa Loa (eye worm) hypothetical protein 0.0113 0.1082 0.137
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0136 0.0136
Onchocerca volvulus 0.0113 0.1082 0.1132
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0877 0.1111
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.2629 0.2629
Schistosoma mansoni hypothetical protein 0.0082 0.068 0.0861
Toxoplasma gondii calcium binding egf domain-containing protein 0.0115 0.1105 0.0589
Toxoplasma gondii microneme protein MIC17C 0.0096 0.0865 0.0258
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0213 0.027
Echinococcus multilocularis glycoprotein Antigen 5 0.0113 0.1082 0.1082
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0858 0.1086
Loa Loa (eye worm) PAN domain-containing protein 0.0096 0.0865 0.1095
Loa Loa (eye worm) hypothetical protein 0.0629 0.7893 1
Brugia malayi PAN domain containing protein 0.0096 0.0865 0.1096
Echinococcus granulosus tissue type plasminogen activator 0.0629 0.7893 1
Brugia malayi Calcium binding EGF domain containing protein 0.0082 0.068 0.0861
Brugia malayi Delta serrate ligand family protein 0.0082 0.068 0.0861
Plasmodium falciparum cysteine repeat modular protein 1 0.0629 0.7893 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0031 0.004
Loa Loa (eye worm) hypothetical protein 0.0096 0.0858 0.1085
Onchocerca volvulus 0.0096 0.0865 0.0849
Echinococcus multilocularis protein jagged 1 0.0082 0.068 0.068
Onchocerca volvulus 0.0113 0.1082 0.1132
Loa Loa (eye worm) hypothetical protein 0.0119 0.1166 0.1476
Toxoplasma gondii microneme protein MIC4 0.0096 0.0865 0.0258
Schistosoma mansoni hypothetical protein 0.004 0.0117 0.0148
Onchocerca volvulus 0.0082 0.068 0.0607
Echinococcus multilocularis neurogenic locus notch protein 0.0082 0.068 0.068
Onchocerca volvulus Putative cubilin 0.0082 0.068 0.0607
Brugia malayi hypothetical protein 0.0113 0.1082 0.1371
Loa Loa (eye worm) hypothetical protein 0.0113 0.1082 0.137
Schistosoma mansoni cercarial elastase (S01 family) 0.0113 0.1082 0.1371
Onchocerca volvulus 0.0096 0.0865 0.0849
Loa Loa (eye worm) hypothetical protein 0.0082 0.068 0.0859
Schistosoma mansoni laminin gamma-3 chain 0.0082 0.068 0.0861
Onchocerca volvulus 0.0096 0.0865 0.0849
Trypanosoma cruzi hypothetical protein, conserved 0.0629 0.7893 0.5
Brugia malayi EGF-like domain containing protein 0.0082 0.068 0.0861
Echinococcus granulosus expressed conserved protein 0.009 0.0781 0.0989
Brugia malayi PAN domain containing protein 0.0096 0.0865 0.1096
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1126 0.1425
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0113 0.1082 0.1371
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0629 0.7893 0.5
Onchocerca volvulus 0.0096 0.0865 0.0849
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.033 0.5
Loa Loa (eye worm) hypothetical protein 0.0082 0.068 0.0859
Echinococcus multilocularis fat cadherin tumor suppressor 0.0082 0.068 0.068
Loa Loa (eye worm) hypothetical protein 0.0082 0.068 0.0859
Echinococcus granulosus neurogenic locus protein delta 0.0082 0.068 0.0861
Brugia malayi PAN domain containing protein 0.0096 0.0865 0.1096
Loa Loa (eye worm) hypothetical protein 0.0096 0.0865 0.1095
Giardia lamblia High cysteine protein 0.0082 0.068 0.5
Echinococcus multilocularis neurogenic locus notch protein 0.0082 0.068 0.068
Loa Loa (eye worm) hypothetical protein 0.0113 0.1082 0.137
Brugia malayi Trypsin family protein 0.0113 0.1082 0.1371
Loa Loa (eye worm) hypothetical protein 0.0082 0.068 0.0859
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.033 0.0418
Onchocerca volvulus 0.0082 0.068 0.0607
Onchocerca volvulus 0.0096 0.0865 0.0849
Echinococcus multilocularis neurogenic locus protein delta 0.0082 0.068 0.068
Loa Loa (eye worm) hypothetical protein 0.0082 0.068 0.0859
Toxoplasma gondii PAN/Apple domain-containing protein 0.0096 0.0865 0.0258
Loa Loa (eye worm) hypothetical protein 0.0033 0.0031 0.0038
Onchocerca volvulus Slit protein homolog 0.0082 0.068 0.0607
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0056 0.0071
Brugia malayi Calcium binding EGF domain containing protein 0.0082 0.068 0.0861
Brugia malayi EGF-like domain containing protein 0.0082 0.068 0.0861
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0031 0.0002 0.0002
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0113 0.1082 0.1371
Brugia malayi Fibulin-1 precursor 0.0115 0.1105 0.14
Schistosoma mansoni hypothetical protein 0.0113 0.1082 0.1371
Brugia malayi hypothetical protein 0.0035 0.0056 0.0071
Schistosoma mansoni hypothetical protein 0.004 0.0117 0.0148
Schistosoma mansoni hypothetical protein 0.0082 0.068 0.0861
Brugia malayi PAN domain containing protein 0.0096 0.0865 0.1096
Echinococcus multilocularis neural cadherin 0.0082 0.068 0.068
Loa Loa (eye worm) PAN domain-containing protein 0.0096 0.0865 0.1095
Loa Loa (eye worm) Notch2 0.0082 0.068 0.0859
Echinococcus granulosus Ankyrin 0.0031 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0115 0.1105 0.1398
Echinococcus granulosus fibropellin Ia 0.0082 0.068 0.0861
Toxoplasma gondii PAN domain-containing protein 0.0096 0.0865 0.0258
Schistosoma mansoni cercarial elastase (S01 family) 0.0113 0.1082 0.1371
Echinococcus multilocularis neurogenic locus notch protein 4 0.0082 0.068 0.068
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0234 0.0294
Schistosoma mansoni egf-like domain protein 0.0115 0.1105 0.14
Loa Loa (eye worm) hypothetical protein 0.0115 0.1105 0.1398
Leishmania major hypothetical protein, conserved 0.0629 0.7893 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.0865 0.1095
Onchocerca volvulus 0.0048 0.0229 0.002
Echinococcus granulosus transmembrane protease serine 3 0.0113 0.1082 0.1371
Echinococcus multilocularis transmembrane protease serine 3 0.0113 0.1082 0.1082
Echinococcus granulosus Tolloid protein 1 0.0115 0.1105 0.14
Echinococcus granulosus Mastin 0.0113 0.1082 0.1371
Schistosoma mansoni cercarial elastase (S01 family) 0.0113 0.1082 0.1371
Echinococcus multilocularis Ankyrin 0.0031 0.0002 0.0002
Brugia malayi Cadherin domain containing protein 0.0082 0.068 0.0861
Onchocerca volvulus 0.0096 0.0865 0.0849
Schistosoma mansoni cercarial elastase (S01 family) 0.0113 0.1082 0.1371
Loa Loa (eye worm) hypothetical protein 0.023 0.2629 0.3329
Loa Loa (eye worm) PAN domain-containing protein 0.0096 0.0865 0.1095
Echinococcus multilocularis laminin 0.0115 0.1105 0.1105
Schistosoma mansoni hypothetical protein 0.0082 0.068 0.0861
Echinococcus granulosus slit 2 protein 0.0082 0.068 0.0861
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0056 0.0071
Schistosoma mansoni patched 1 0.0041 0.0136 0.0173
Onchocerca volvulus 0.0082 0.068 0.0607
Echinococcus multilocularis protein jagged 1 0.0082 0.068 0.068
Brugia malayi PAN domain containing protein 0.0096 0.0865 0.1096
Loa Loa (eye worm) hypothetical protein 0.0082 0.068 0.0859
Onchocerca volvulus 0.0113 0.1082 0.1132
Echinococcus granulosus survival motor neuron protein 1 0.023 0.2629 0.333
Toxoplasma gondii calcium binding egf domain-containing protein 0.0115 0.1105 0.0589
Loa Loa (eye worm) PAN domain-containing protein 0.0096 0.0865 0.1095
Brugia malayi Trypsin family protein 0.0113 0.1082 0.1371
Onchocerca volvulus 0.0629 0.7893 1
Echinococcus multilocularis tumor protein p63 0.0329 0.393 0.393
Echinococcus granulosus enteropeptidase 0.0113 0.1082 0.1371
Onchocerca volvulus 0.0082 0.068 0.0607
Onchocerca volvulus 0.0113 0.1082 0.1132
Echinococcus multilocularis neurogenic locus protein delta 0.0082 0.068 0.068
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0082 0.068 0.0607
Onchocerca volvulus 0.0113 0.1082 0.1132
Loa Loa (eye worm) hypothetical protein 0.0082 0.068 0.0859
Echinococcus granulosus glycoprotein Antigen 5 0.0113 0.1082 0.1371
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0115 0.1105 0.14
Schistosoma mansoni cercarial elastase (S01 family) 0.0113 0.1082 0.1371
Toxoplasma gondii PAN domain-containing protein 0.0096 0.0865 0.0258
Brugia malayi EGF-like domain containing protein 0.0082 0.068 0.0861
Loa Loa (eye worm) hypothetical protein 0.0113 0.1082 0.137
Brugia malayi hypothetical protein 0.023 0.2629 0.333
Echinococcus granulosus neural cadherin 0.0082 0.068 0.0861
Echinococcus multilocularis slit 2 protein 0.0082 0.068 0.068
Brugia malayi notch-like transmembrane receptor 0.0082 0.068 0.0861
Schistosoma mansoni hypothetical protein 0.0082 0.068 0.0861
Echinococcus granulosus protein jagged 1 0.0082 0.068 0.0861
Loa Loa (eye worm) hypothetical protein 0.0082 0.068 0.0859
Echinococcus multilocularis enteropeptidase 0.0113 0.1082 0.1082
Toxoplasma gondii microneme protein MIC17B 0.0096 0.0865 0.0258
Loa Loa (eye worm) hypothetical protein 0.0082 0.068 0.0859
Loa Loa (eye worm) hypothetical protein 0.0082 0.068 0.0859
Echinococcus granulosus protein jagged 1 0.0082 0.068 0.0861
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0082 0.068 0.0861
Onchocerca volvulus 0.0096 0.0865 0.0849
Echinococcus multilocularis fibropellin Ia 0.0082 0.068 0.068
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.033 0.0418
Loa Loa (eye worm) hypothetical protein 0.005 0.0258 0.0325
Echinococcus granulosus laminin 0.0115 0.1105 0.14
Loa Loa (eye worm) TK/ROR protein kinase 0.0629 0.7893 1
Schistosoma mansoni notch 0.0082 0.068 0.0861
Mycobacterium ulcerans hypothetical protein 0.0113 0.1082 1
Schistosoma mansoni hypothetical protein 0.0033 0.0031 0.004
Onchocerca volvulus 0.0096 0.0865 0.0849
Brugia malayi hypothetical protein 0.0119 0.1166 0.1478
Schistosoma mansoni hypothetical protein 0.0082 0.068 0.0861
Loa Loa (eye worm) hypothetical protein 0.0096 0.0865 0.1095
Loa Loa (eye worm) hypothetical protein 0.0082 0.068 0.0859
Schistosoma mansoni cercarial elastase (S01 family) 0.0113 0.1082 0.1371
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0136 0.0171
Loa Loa (eye worm) hypothetical protein 0.0048 0.0234 0.0294
Loa Loa (eye worm) hypothetical protein 0.0082 0.068 0.0859
Loa Loa (eye worm) hypothetical protein 0.0082 0.068 0.0859
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0113 0.1082 0.1371
Loa Loa (eye worm) hypothetical protein 0.0082 0.068 0.0859
Brugia malayi PAN domain containing protein 0.0096 0.0865 0.1096
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.14 0.14
Schistosoma mansoni survival motor neuron protein 0.0047 0.0213 0.027
Loa Loa (eye worm) hypothetical protein 0.0096 0.0865 0.1095
Echinococcus granulosus neurogenic locus notch protein 0.0082 0.068 0.0861
Brugia malayi Muscle positioning protein 4 0.0082 0.068 0.0861
Schistosoma mansoni notch 0.0082 0.068 0.0861
Toxoplasma gondii microneme protein MIC17A 0.0096 0.0865 0.0258
Loa Loa (eye worm) hypothetical protein 0.0096 0.0865 0.1095
Brugia malayi EGF-like domain containing protein 0.0082 0.068 0.0861
Echinococcus granulosus notch 0.0082 0.068 0.0861
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0113 0.1082 0.1371
Brugia malayi PAN domain containing protein 0.0096 0.0865 0.1096
Loa Loa (eye worm) hypothetical protein 0.0082 0.068 0.0859
Onchocerca volvulus 0.0082 0.068 0.0607
Brugia malayi PAN domain containing protein 0.0096 0.0865 0.1096
Loa Loa (eye worm) hypothetical protein 0.0115 0.1105 0.1398
Onchocerca volvulus 0.0096 0.0865 0.0849
Schistosoma mansoni septate junction protein 0.0082 0.068 0.0861
Brugia malayi Kringle domain containing protein 0.0629 0.7893 1
Schistosoma mansoni hypothetical protein 0.0082 0.068 0.0861
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0115 0.1105 0.1398
Schistosoma mansoni notch 0.0082 0.068 0.0861
Brugia malayi Trypsin family protein 0.0113 0.1082 0.1371
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0113 0.1082 0.1371
Brugia malayi Trypsin-like protease protein 5 0.0113 0.1082 0.1371
Toxoplasma gondii subtilisin SUB12 0.0096 0.0865 0.0258
Loa Loa (eye worm) hypothetical protein 0.0096 0.0865 0.1095
Schistosoma mansoni hypothetical protein 0.0113 0.1082 0.1371
Loa Loa (eye worm) hypothetical protein 0.0096 0.0865 0.1095
Echinococcus granulosus protein jagged 2 0.0082 0.068 0.0861
Loa Loa (eye worm) hypothetical protein 0.0113 0.1082 0.137
Brugia malayi MH2 domain containing protein 0.0116 0.1126 0.1427
Brugia malayi Protein kinase domain containing protein 0.0629 0.7893 1
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0115 0.1105 0.14
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0234 0.0296
Onchocerca volvulus Arrow homolog 0.0115 0.1105 0.1161
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0136 0.5
Echinococcus multilocularis fibrillin 1 0.0115 0.1105 0.1105
Brugia malayi Calcium binding EGF domain containing protein 0.0082 0.068 0.0861
Schistosoma mansoni hypothetical protein 0.0047 0.0213 0.027
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1126 0.1425
Schistosoma mansoni notch 0.0082 0.0681 0.0863
Toxoplasma gondii kringle domain-containing protein 0.0629 0.7893 1
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0136 0.0173
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0229 0.029
Schistosoma mansoni cercarial elastase (S01 family) 0.0113 0.1082 0.1371
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0113 0.1082 0.1371
Schistosoma mansoni notch 0.0082 0.068 0.0861
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0082 0.068 0.0861
Brugia malayi GCC2 and GCC3 family protein 0.0082 0.068 0.0861
Brugia malayi Trypsin family protein 0.0113 0.1082 0.1371
Brugia malayi CHE-14 protein 0.0041 0.0136 0.0173
Onchocerca volvulus 0.0096 0.0865 0.0849
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0858 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0113 0.1082 0.1371
Echinococcus multilocularis expressed conserved protein 0.009 0.0781 0.0781
Schistosoma mansoni hypothetical protein 0.004 0.0117 0.0148
Schistosoma mansoni cercarial elastase (S01 family) 0.0113 0.1082 0.1371
Brugia malayi PAN domain containing protein 0.0096 0.0865 0.1096
Onchocerca volvulus 0.0113 0.1082 0.1132
Echinococcus granulosus nuclear factor of activated T cells 5 0.0301 0.3563 0.4514
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.033 0.0418
Loa Loa (eye worm) hypothetical protein 0.0082 0.068 0.0859
Loa Loa (eye worm) hypothetical protein 0.0115 0.1105 0.1398
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0113 0.1082 0.1371
Toxoplasma gondii PAN domain-containing protein 0.0367 0.4438 0.521
Loa Loa (eye worm) PAN domain-containing protein 0.0096 0.0865 0.1095
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0113 0.1082 0.1371
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0115 0.1105 0.1398
Echinococcus granulosus neurogenic locus notch protein 0.0082 0.068 0.0861
Echinococcus multilocularis tissue type plasminogen activator 0.0629 0.7893 0.7893
Brugia malayi EGF-like domain containing protein 0.0082 0.068 0.0861
Schistosoma mansoni cercarial elastase (S01 family) 0.0113 0.1082 0.1371
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0056 0.0056
Echinococcus multilocularis protein patched 0.0041 0.0136 0.0136
Loa Loa (eye worm) notch protein 0.0082 0.068 0.0859
Onchocerca volvulus Neurogenic locus notch homolog 0.0082 0.0681 0.0609
Brugia malayi EGF-like domain containing protein 0.0082 0.068 0.0861
Toxoplasma gondii PAN domain-containing protein 0.0367 0.4438 0.521
Brugia malayi Cadherin domain containing protein 0.0082 0.068 0.0861
Schistosoma mansoni hypothetical protein 0.004 0.0117 0.0148
Echinococcus granulosus protein jagged 2 0.0082 0.068 0.0861
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0113 0.1082 0.1082
Echinococcus multilocularis protein dispatched 1 0.0047 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.0113 0.1082 0.137
Loa Loa (eye worm) hypothetical protein 0.0082 0.068 0.0859
Loa Loa (eye worm) hypothetical protein 0.0082 0.068 0.0859
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0115 0.1105 0.1398
Schistosoma mansoni hypothetical protein 0.0629 0.7893 1

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 100 uM Compound was tested for the antiviral activity against Human Rhinovirus -14(HRV-14) in HeLa cells ChEMBL. 8978838
EC50 (functional) > 100 uM Compound was tested for the antiviral activity against Human Rhinovirus -14(HRV-14) in HeLa cells ChEMBL. 8978838
Ki (binding) = 0.004 uM Inhibition of human rhinovirus 3C protease ChEMBL. 8978838
Ki (binding) = 0.004 uM Inhibition of human rhinovirus 3C protease ChEMBL. 8978838
TC50 (functional) > 100 uM Compound was tested for the 50% toxic concentration against Human Rhinovirus-14 (HRV-14) in Hela cells ChEMBL. 8978838
TC50 (functional) > 100 uM Compound was tested for the 50% toxic concentration against Human Rhinovirus-14 (HRV-14) in Hela cells ChEMBL. 8978838

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.