Detailed information for compound 263287

Basic information

Technical information
  • TDR Targets ID: 263287
  • Name: 3-[(3E,7E,11E,15E)-16-ethenyl-3,7,12,20-tetra methylhenicosa-3,7,11,15,19-pentaenyl]-2,2-di methyloxirane
  • MW: 438.728 | Formula: C31H50O
  • H donors: 0 H acceptors: 0 LogP: 10.69 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=C/C(=C/CC/C(=C/CC/C=C(/CC/C=C(/CCC1OC1(C)C)\C)\C)/C)/CCC=C(C)C
  • InChi: 1S/C31H50O/c1-9-29(21-12-15-25(2)3)22-14-20-27(5)17-11-10-16-26(4)18-13-19-28(6)23-24-30-31(7,8)32-30/h9,15-17,19,22,30H,1,10-14,18,20-21,23-24H2,2-8H3/b26-16+,27-17+,28-19+,29-22-
  • InChiKey: ATMHMBRPCUZUGJ-WVFMSAHCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,2-dimethyl-3-[(3E,7E,11E,15E)-3,7,12,20-tetramethyl-16-vinyl-henicosa-3,7,11,15,19-pentaenyl]oxirane
  • 2,2-dimethyl-3-[(3E,7E,11E,15E)-3,7,12,20-tetramethyl-16-vinylhenicosa-3,7,11,15,19-pentaenyl]oxirane
  • 3-[(3E,7E,11E,15E)-16-ethenyl-3,7,12,20-tetramethyl-henicosa-3,7,11,15,19-pentaenyl]-2,2-dimethyl-oxirane

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Lanosterol synthase Starlite/ChEMBL References
Homo sapiens lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense lanosterol synthase Get druggable targets OG5_127966 All targets in OG5_127966
Trypanosoma cruzi lanosterol synthase, putative Get druggable targets OG5_127966 All targets in OG5_127966
Trypanosoma brucei gambiense lanosterol synthase Get druggable targets OG5_127966 All targets in OG5_127966
Leishmania mexicana lanosterol synthase, putative Get druggable targets OG5_127966 All targets in OG5_127966
Candida albicans 2,3-oxidosqualene-lanosterol cyclase Get druggable targets OG5_127966 All targets in OG5_127966
Trypanosoma brucei lanosterol synthase Get druggable targets OG5_127966 All targets in OG5_127966
Leishmania braziliensis lanosterol synthase, putative Get druggable targets OG5_127966 All targets in OG5_127966
Leishmania infantum lanosterol synthase, putative Get druggable targets OG5_127966 All targets in OG5_127966
Leishmania donovani lanosterol synthase, putative Get druggable targets OG5_127966 All targets in OG5_127966
Candida albicans 2,3-oxidosqualene-lanosterol cyclase Get druggable targets OG5_127966 All targets in OG5_127966
Leishmania major lanosterol synthase, putative Get druggable targets OG5_127966 All targets in OG5_127966
Trypanosoma cruzi lanosterol synthase, putative Get druggable targets OG5_127966 All targets in OG5_127966
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis 0.1028 0.1769 0.1769
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0959 0.1633 1
Echinococcus granulosus disintegrin and metalloproteinase 0.0143 0.0038 0.0033
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0152 0.0057 0.0057
Onchocerca volvulus 0.1863 0.3402 0.528
Echinococcus granulosus hemicentin 1 0.0228 0.0205 0.02
Loa Loa (eye worm) hypothetical protein 0.0224 0.0198 0.0287
Brugia malayi Immunoglobulin I-set domain containing protein 0.0224 0.0198 0.0287
Loa Loa (eye worm) TK protein kinase 0.0152 0.0057 0.0083
Brugia malayi Protein kinase domain containing protein 0.1096 0.1902 0.2767
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.0275 1
Schistosoma mansoni basigin related 0.0126 0.0005 0.0008
Echinococcus multilocularis netrin receptor unc 5 0.0126 0.0005 0.0005
Schistosoma mansoni cell adhesion molecule 0.0224 0.0198 0.0313
Onchocerca volvulus 0.3073 0.5768 0.906
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.0275 1
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0224 0.0198 0.0287
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0224 0.0198 0.0287
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0224 0.0198 0.0198
Echinococcus multilocularis lachesin 0.0224 0.0198 0.0198
Brugia malayi Disintegrin family protein 0.0143 0.0038 0.0055
Brugia malayi Immunoglobulin I-set domain containing protein 0.0224 0.0198 0.0287
Loa Loa (eye worm) hypothetical protein 0.0126 0.0005 0.0007
Schistosoma mansoni nephrin related 0.0126 0.0005 0.0008
Echinococcus multilocularis adam 0.0246 0.0239 0.0239
Echinococcus multilocularis roundabout 2 0.061 0.0952 0.0952
Echinococcus granulosus Immunoglobulin 0.0386 0.0514 0.0509
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0211 0.0172 0.0172
Schistosoma mansoni basigin related 0.0126 0.0005 0.0008
Brugia malayi Immunoglobulin I-set domain containing protein 0.0224 0.0198 0.0287
Trypanosoma cruzi lanosterol synthase, putative 0.0415 0.0569 0.5
Loa Loa (eye worm) hypothetical protein 0.0386 0.0514 0.0747
Schistosoma mansoni nephrin 0.0485 0.0706 0.1117
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0224 0.0198 0.0198
Echinococcus granulosus insulin growth factor 1 receptor beta 0.1096 0.1902 0.1898
Onchocerca volvulus Tyrosine kinase homolog 0.3226 0.6066 0.9536
Loa Loa (eye worm) hypothetical protein 0.1446 0.2587 0.3763
Loa Loa (eye worm) hypothetical protein 0.0224 0.0198 0.0287
Schistosoma mansoni tyrosine kinase 0.1819 0.3316 0.5246
Loa Loa (eye worm) hypothetical protein 0.0386 0.0514 0.0747
Brugia malayi Immunoglobulin I-set domain containing protein 0.3639 0.6874 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.1096 0.1902 0.1902
Echinococcus multilocularis disintegrin and metalloproteinase 0.0143 0.0038 0.0038
Schistosoma mansoni septate junction protein 0.0126 0.0005 0.0008
Echinococcus granulosus peroxidasin 0.0224 0.0198 0.0193
Echinococcus multilocularis cell adhesion molecule:down regulated by 0.0126 0.0005 0.0005
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0264 0.0275 0.04
Trypanosoma brucei lanosterol synthase 0.0415 0.0569 0.5
Brugia malayi Matrixin family protein 0.1446 0.2587 0.3763
Trypanosoma cruzi lanosterol synthase, putative 0.0415 0.0569 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.013 0.0012 0.0018
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0126 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0224 0.0198 0.0287
Schistosoma mansoni tyrosine kinase 0.0278 0.0303 0.0479
Brugia malayi Immunoglobulin domain containing protein 0.0126 0.0005 0.0007
Brugia malayi Fibronectin type III domain containing protein 0.0386 0.0514 0.0747
Loa Loa (eye worm) matrix metalloproteinase 0.1446 0.2587 0.3763
Echinococcus granulosus epidermal growth factor receptor 0.3356 0.6321 0.6319
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0386 0.0514 0.0514
Loa Loa (eye worm) hypothetical protein 0.0126 0.0005 0.0007
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0189 0.0128 0.0202
Loa Loa (eye worm) matrixin family protein 0.3153 0.5925 0.8619
Schistosoma mansoni nephrin 0.0224 0.0198 0.0313
Loa Loa (eye worm) hypothetical protein 0.0126 0.0005 0.0007
Echinococcus multilocularis Immunoglobulin 0.0386 0.0514 0.0514
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0166 0.0084 0.0084
Echinococcus multilocularis Immunoglobulin 0.0126 0.0005 0.0005
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0211 0.0172 0.0272
Echinococcus multilocularis insulin receptor 0.1096 0.1902 0.1902
Loa Loa (eye worm) hypothetical protein 0.0224 0.0198 0.0287
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0224 0.0198 0.0287
Echinococcus granulosus lachesin 0.0224 0.0198 0.0193
Schistosoma mansoni polycystin 1-related 0.0225 0.0199 0.0314
Echinococcus multilocularis Immunoglobulin 0.0386 0.0514 0.0514
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0224 0.0198 0.0313
Brugia malayi Immunoglobulin I-set domain containing protein 0.0386 0.0514 0.0747
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.1282 0.2265 0.3583
Schistosoma mansoni cell adhesion molecule 0.0224 0.0198 0.0313
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0959 0.1633 0.1629
Schistosoma mansoni tyrosine kinase 0.3356 0.6321 1
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.1707 0.3097 1
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.0275 1
Loa Loa (eye worm) hypothetical protein 0.061 0.0952 0.1385
Schistosoma mansoni cell adhesion molecule 0.0512 0.076 0.1202
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0126 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0126 0.0005 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.0275 1
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.0275 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0126 0.0005 0.0007
Echinococcus granulosus roundabout 2 0.0224 0.0198 0.0193
Loa Loa (eye worm) hypothetical protein 0.0224 0.0198 0.0287
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0213 0.0176 0.0176
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0213 0.0176 0.0171
Brugia malayi Peroxidasin 0.0224 0.0198 0.0287
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0512 0.076 0.0755
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.1707 0.3097 0.4505
Mycobacterium leprae PROBABLE HYDROLASE 0.1707 0.3097 0.5
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0224 0.0198 0.0193
Brugia malayi Immunoglobulin I-set domain containing protein 0.0224 0.0198 0.0287
Echinococcus granulosus adam 17 protease 0.0269 0.0284 0.0279
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0126 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0386 0.0514 0.0747
Schistosoma mansoni hypothetical protein 0.0126 0.0005 0.0008
Brugia malayi angiogenesis inhibito 0.0141 0.0035 0.0051
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0116 0.1027
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0224 0.0198 0.016
Schistosoma mansoni hypothetical protein 0.0126 0.0005 0.0008
Brugia malayi Matrixin family protein 0.353 0.6662 0.9691
Brugia malayi Immunoglobulin domain containing protein 0.0126 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0386 0.0514 0.0747
Brugia malayi Immunoglobulin I-set domain containing protein 0.0126 0.0005 0.0007
Schistosoma mansoni hypothetical protein 0.0126 0.0005 0.0008
Brugia malayi Matrixin family protein 0.1446 0.2587 0.3763
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0126 0.0005 0.0005
Schistosoma mansoni tyrosine kinase 0.1096 0.1902 0.301
Onchocerca volvulus Matrix metalloproteinase homolog 0.3153 0.5925 0.931
Brugia malayi Immunoglobulin I-set domain containing protein 0.0224 0.0198 0.0287
Loa Loa (eye worm) hypothetical protein 0.061 0.0952 0.1385
Schistosoma mansoni hypothetical protein 0.0126 0.0005 0.0008
Loa Loa (eye worm) TK/KIN16 protein kinase 0.3639 0.6874 1
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.1667 0.3018 0.4775
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0224 0.0198 0.0198
Echinococcus granulosus roundabout 2 0.061 0.0952 0.0948
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.0275 1
Schistosoma mansoni hypothetical protein 0.1863 0.3402 0.5383
Schistosoma mansoni peroxidasin 0.0126 0.0005 0.0008
Brugia malayi Immunoglobulin I-set domain containing protein 0.0126 0.0005 0.0007
Echinococcus multilocularis epidermal growth factor receptor 0.1819 0.3316 0.3316
Brugia malayi Reprolysin 0.0131 0.0016 0.0023
Schistosoma mansoni titin 0.0228 0.0205 0.0324
Echinococcus multilocularis hemicentin 1 0.0228 0.0205 0.0205
Brugia malayi Heparan sulfate 0.0126 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0491 0.072 0.1047
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0246 0.0239 0.0378
Schistosoma mansoni tyrosine kinase 0.1765 0.3211 0.508
Loa Loa (eye worm) hypothetical protein 0.0138 0.0028 0.004
Brugia malayi Prion-like- 0.0224 0.0198 0.0287
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0211 0.0172 0.0167
Brugia malayi basement membrane proteoglycan 0.0126 0.0005 0.0007
Brugia malayi hypothetical protein 0.0386 0.0514 0.0747
Loa Loa (eye worm) hypothetical protein 0.0126 0.0005 0.0007
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0166 0.0084 0.0079
Brugia malayi Matrixin family protein 0.1446 0.2587 0.3763
Loa Loa (eye worm) TK/EGFR protein kinase 0.3356 0.6321 0.9195
Brugia malayi Immunoglobulin I-set domain containing protein 0.0224 0.0198 0.0287
Loa Loa (eye worm) hypothetical protein 0.1446 0.2587 0.3763
Echinococcus granulosus neuroglian 0.0224 0.0198 0.0193
Loa Loa (eye worm) hypothetical protein 0.1707 0.3097 0.4505
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.5237 1 1
Echinococcus granulosus contactin 0.0224 0.0198 0.0193
Brugia malayi basement membrane proteoglycan precursor 0.0126 0.0005 0.0007
Schistosoma mansoni tyrosine kinase 0.1096 0.1902 0.301
Echinococcus multilocularis roundabout 2 0.0224 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0224 0.0198 0.0287
Brugia malayi Immunoglobulin I-set domain containing protein 0.0152 0.0057 0.0083
Echinococcus multilocularis epidermal growth factor receptor 0.3356 0.6321 0.6321
Brugia malayi ADAMTS-like protease 0.0141 0.0035 0.0051
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0224 0.0198 0.0198
Echinococcus multilocularis tyrosine protein kinase otk 0.0224 0.0198 0.0198
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0386 0.0514 0.0812
Schistosoma mansoni hypothetical protein 0.0126 0.0005 0.0008
Onchocerca volvulus Matrilysin homolog 0.3374 0.6356 1
Loa Loa (eye worm) TK/INSR protein kinase 0.1096 0.1902 0.2767
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0126 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0126 0.0005 0.0007
Loa Loa (eye worm) matrixin family protein 0.353 0.6662 0.9691
Echinococcus multilocularis hemicentin 1 0.0224 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.1667 0.3018 0.4391
Echinococcus multilocularis roundabout 2 0.0224 0.0198 0.0198
Echinococcus granulosus epidermal growth factor receptor 0.1819 0.3316 0.3313
Brugia malayi hypothetical protein 0.0246 0.0239 0.0347
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0126 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0224 0.0198 0.0287
Echinococcus granulosus roundabout 2 0.0224 0.0198 0.0193
Schistosoma mansoni neuroglian 0.0224 0.0198 0.0313
Echinococcus granulosus sodium channel protein 0.0959 0.1633 0.1629
Schistosoma mansoni cell adhesion molecule 0.0126 0.0005 0.0008
Schistosoma mansoni netrin receptor unc5 0.0126 0.0005 0.0008
Schistosoma mansoni cell adhesion molecule 0.0224 0.0198 0.0313
Brugia malayi Immunoglobulin I-set domain containing protein 0.0224 0.0198 0.0287
Mycobacterium ulcerans hydrolase 0.1707 0.3097 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0116 0.1027
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0264 0.0275 0.04
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1232 0.2169 0.3431
Echinococcus multilocularis Immunoglobulin subtype 0.0126 0.0005 0.0005
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0386 0.0514 0.0812
Echinococcus multilocularis sodium channel protein 0.0959 0.1633 0.1633
Brugia malayi Hemopexin family protein 0.1863 0.3402 0.4949
Brugia malayi Furin-like cysteine rich region family protein 0.3356 0.6321 0.9195
Echinococcus granulosus insulin receptor 0.1096 0.1902 0.1898
Schistosoma mansoni septate junction protein 0.0224 0.0198 0.0313
Loa Loa (eye worm) hypothetical protein 0.027 0.0286 0.0416
Echinococcus granulosus defective proboscis extension response 0.0386 0.0514 0.0509
Loa Loa (eye worm) reprolysin 0.0211 0.0172 0.025
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0152 0.0057 0.0052
Echinococcus multilocularis neuroglian 0.0224 0.0198 0.0198
Echinococcus granulosus neuroglian 0.0485 0.0706 0.0702
Loa Loa (eye worm) hypothetical protein 0.0158 0.0068 0.0099
Schistosoma mansoni septate junction protein 0.0126 0.0005 0.0008
Brugia malayi hypothetical protein 0.0126 0.0005 0.0007
Loa Loa (eye worm) TK/ROR protein kinase 0.0152 0.0057 0.0083
Echinococcus multilocularis Immunoglobulin 0.0126 0.0005 0.0005
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0126 0.0005 0.0005
Schistosoma mansoni basigin related 0.0126 0.0005 0.0008
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0224 0.0198 0.0313
Onchocerca volvulus Matrilysin homolog 0.1446 0.2587 0.3977
Loa Loa (eye worm) hypothetical protein 0.0386 0.0514 0.0747
Echinococcus multilocularis peroxidasin 0.0224 0.0198 0.0198
Onchocerca volvulus 0.1446 0.2587 0.3977
Echinococcus granulosus adam 0.0246 0.0239 0.0234
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0224 0.0197 0.0311
Schistosoma mansoni tyrosine kinase 0.1819 0.3316 0.5246
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0224 0.0198 0.0287
Brugia malayi Immunoglobulin domain containing protein 0.0126 0.0005 0.0007
Schistosoma mansoni cell adhesion molecule 0.0126 0.0005 0.0008
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0224 0.0198 0.0198
Echinococcus multilocularis adam 17 protease 0.0189 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0386 0.0514 0.0747
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0166 0.0084 0.0133
Brugia malayi Immunoglobulin I-set domain containing protein 0.0126 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0224 0.0198 0.0287
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0126 0.0005 0.0007
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.2559 0.4763 0.5
Echinococcus granulosus tyrosine protein kinase otk 0.0224 0.0198 0.0193
Schistosoma mansoni tyrosine kinase 0.1765 0.3211 0.508
Brugia malayi Matrixin family protein 0.1446 0.2587 0.3763
Brugia malayi Immunoglobulin I-set domain containing protein 0.0224 0.0198 0.0287
Echinococcus granulosus twitchin 0.0485 0.0706 0.0702
Schistosoma mansoni netrin receptor unc5 0.0126 0.0005 0.0008
Echinococcus multilocularis neuroglian 0.0485 0.0706 0.0706
Schistosoma mansoni vesicular amine transporter 0.0448 0.0635 0.1004
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0126 0.0005 0.0008
Schistosoma mansoni tyrosine kinase 0.1765 0.3211 0.508
Schistosoma mansoni roundabout 0.0224 0.0198 0.0313
Brugia malayi ADAM-TS Spacer 1 family protein 0.027 0.0286 0.0416
Loa Loa (eye worm) hypothetical protein 0.0512 0.076 0.1105
Echinococcus multilocularis leucine rich repeat containing protein 4 0.0126 0.0005 0.0005
Loa Loa (eye worm) immunoglobulin domain-containing protein 0.0126 0.0005 0.0007
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0126 0.0005 0.0008
Loa Loa (eye worm) LAD-2 short isoform 0.0126 0.0005 0.0007
Schistosoma mansoni dihydroceramide desaturase 0.0143 0.0038 0.006
Brugia malayi Immunoglobulin I-set domain containing protein 0.0224 0.0198 0.0287
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0568 0.0869 0.2148
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0211 0.0172 0.0272
Schistosoma mansoni septate junction protein 0.0224 0.0198 0.0313
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.1819 0.3316 0.3313

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4 uM Compound was tested for inhibition of solubilized and partially purified pig liver Oxidosqualene-lanosterol cyclase ChEMBL. 9484504
IC50 (binding) = 4 uM Compound was tested for inhibition of solubilized and partially purified pig liver Oxidosqualene-lanosterol cyclase ChEMBL. 9484504
IC50 (binding) = 5 uM Compound was tested for inhibition of solubilized and partially purified Saccharomyces cerevisae Oxidosqualene-lanosterol cyclase ChEMBL. 9484504
IC50 (binding) = 5 uM Compound was tested for inhibition of solubilized and partially purified Saccharomyces cerevisae Oxidosqualene-lanosterol cyclase ChEMBL. 9484504

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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