Detailed information for compound 263404

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 357.382 | Formula: C14H19N3O6S
  • H donors: 4 H acceptors: 6 LogP: 0.07 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC(C(=O)O)C(C)C)CNC(=O)c1ccc(cc1)S(=O)(=O)N
  • InChi: 1S/C14H19N3O6S/c1-8(2)12(14(20)21)17-11(18)7-16-13(19)9-3-5-10(6-4-9)24(15,22)23/h3-6,8,12H,7H2,1-2H3,(H,16,19)(H,17,18)(H,20,21)(H2,15,22,23)
  • InChiKey: TVBXEIUTDFUCCT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens carbonic anhydrase II Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania infantum carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) carbonic anhydrase 3 Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania braziliensis carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus granulosus carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania mexicana carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei gambiense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus multilocularis carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Putative carbonic anhydrase 5 precursor Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania major carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Eukaryotic-type carbonic anhydrase family protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania donovani carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Carbonic anhydrase like protein 2 precursor carbonic anhydrase II 260 aa 259 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0223 0.064 0.1195
Schistosoma mansoni amine GPCR 0.0223 0.064 0.1195
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0223 0.064 0.1195
Loa Loa (eye worm) G-protein coupled receptor 0.0223 0.064 0.1195
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0044 0.0029
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0147 0.0412 0.075
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0034 0.0063
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0147 0.0412 0.0769
Echinococcus granulosus g protein coupled receptor 0.0223 0.064 0.1195
Schistosoma mansoni hypothetical protein 0.0068 0.0175 0.0326
Loa Loa (eye worm) hypothetical protein 0.0062 0.0156 0.0291
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0156 0.0601
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0223 0.064 0.1195
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0538 0.1584 0.2944
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.0346 0.0647
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.01 0.0269 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0259 0.0259
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0034 0.0063
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0034 0.0063
Leishmania major heat shock protein 83-1 0.01 0.0269 0.0484
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0156 0.0601
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0034 0.0063
Loa Loa (eye worm) neuropeptide F receptor 0.0223 0.064 0.1195
Brugia malayi ecdysteroid receptor 0.0021 0.0034 0.0063
Schistosoma mansoni DNA topoisomerase II 0.01 0.0269 0.0503
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.01 0.0269 1
Trichomonas vaginalis receptor histidine kinase, putative 0.01 0.0269 0.339
Echinococcus granulosus CREB binding protein 0.0103 0.0278 0.0519
Onchocerca volvulus 0.0223 0.064 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0223 0.064 0.1195
Schistosoma mansoni biogenic amine (5HT) receptor 0.0223 0.064 0.1195
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0156 0.1905
Schistosoma mansoni neuropeptide F-like receptor 0.0223 0.064 0.1195
Trypanosoma brucei Heat shock protein 83, putative 0.01 0.0269 0.0452
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0034 0.0063
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0028 0.0033
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Brugia malayi RNA binding protein 0.0125 0.0346 0.0647
Echinococcus granulosus intermediate filament protein 0.0029 0.0057 0.0107
Brugia malayi Serotonin receptor 0.0223 0.064 0.1195
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0156 0.0272
Echinococcus granulosus sex peptide receptor 0.0223 0.064 0.1195
Trypanosoma cruzi heat shock protein 85, putative 0.01 0.0269 0.0484
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0062 0.0156 0.024
Brugia malayi Serotonin receptor 0.0223 0.064 0.1195
Brugia malayi follicle stimulating hormone receptor 0.0223 0.064 0.1195
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0007
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0082 0.0082
Plasmodium falciparum DNA gyrase subunit B 0.01 0.0269 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.002
Onchocerca volvulus 0.0223 0.064 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0044 0.0072
Onchocerca volvulus 0.0223 0.064 1
Echinococcus granulosus GPCR family 2 0.0032 0.0065 0.0121
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0156 0.1905
Trichomonas vaginalis sensor histidine kinase, putative 0.01 0.0269 0.339
Brugia malayi TAR-binding protein 0.0125 0.0346 0.0647
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0223 0.064 0.1195
Loa Loa (eye worm) hypothetical protein 0.0062 0.0156 0.0291
Schistosoma mansoni survival motor neuron protein 0.0052 0.0126 0.0235
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0156 0.0601
Schistosoma mansoni amine GPCR 0.0223 0.064 0.1195
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0044 0.0061
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.01 0.0269 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0223 0.064 0.1195
Echinococcus granulosus rhodopsin orphan GPCR 0.0223 0.064 0.1195
Brugia malayi Probable DNA topoisomerase II 0.01 0.0269 0.0503
Echinococcus multilocularis carbonic anhydrase II 0.0147 0.0412 0.0412
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0065 0.0065
Plasmodium vivax endoplasmin, putative 0.01 0.0269 0.1549
Leishmania major heat shock protein 83-1 0.01 0.0269 0.0484
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0028 0.023
Echinococcus multilocularis protein tyrosine kinase 0.017 0.048 0.048
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.01 0.0269 0.0452
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0147 0.0412 0.0769
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0034 0.0034
Echinococcus granulosus carbonic anhydrase II 0.0147 0.0412 0.0769
Brugia malayi Dopamine receptor protein 1 0.0223 0.064 0.1195
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0062 0.0156 0.0291
Brugia malayi RE15519p 0.0223 0.064 0.1195
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0627 0.1853 0.3424
Leishmania major heat shock protein 83-1 0.01 0.0269 0.0484
Brugia malayi ORL1-like opioid receptor 0.0223 0.064 0.1195
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0156 0.1905
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0062 0.0156 0.024
Trypanosoma cruzi DNA topoisomerase II, putative 0.01 0.0269 0.0484
Echinococcus multilocularis orexin receptor type 2 0.0223 0.064 0.064
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0062 0.0156 0.0291
Schistosoma mansoni tyrosine kinase 0.017 0.048 0.0896
Schistosoma mansoni hypothetical protein 0.0032 0.0065 0.0121
Echinococcus multilocularis dnaJ subfamily B 0.0424 0.1243 0.1243
Echinococcus granulosus peptide allatostatin:somatostatin 0.0223 0.064 0.1195
Echinococcus multilocularis fmrfamide receptor 0.0223 0.064 0.064
Loa Loa (eye worm) hypothetical protein 0.0029 0.0055 0.0104
Schistosoma mansoni heat shock protein 0.01 0.0269 0.0503
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0156 0.1905
Mycobacterium ulcerans two component regulator - sensor kinase 0.01 0.0269 1
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0103 0.0278 0.0519
Brugia malayi Dopamine receptor 0.0223 0.064 0.1195
Loa Loa (eye worm) carbonic anhydrase 3 0.0147 0.0412 0.0769
Schistosoma mansoni ap endonuclease 0.0019 0.0028 0.0053
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.01 0.0269 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0062 0.0156 0.0291
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0062 0.0156 0.1905
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0063
Echinococcus multilocularis serotonin receptor 0.0223 0.064 0.064
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0497 0.6377
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0156 0.0601
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0223 0.064 0.1195
Trichomonas vaginalis heat shock protein, putative 0.01 0.0269 0.339
Schistosoma mansoni opsin-like receptor 0.0223 0.064 0.1195
Entamoeba histolytica hypothetical protein 0.0037 0.0082 0.2217
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0346 0.0647
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.01 0.0269 1
Echinococcus multilocularis g protein coupled receptor 0.0223 0.064 0.064
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0062 0.0156 0.024
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0065 0.0065
Mycobacterium tuberculosis Two component sensor kinase MprB 0.01 0.0269 1
Schistosoma mansoni biogenic amine receptor 0.0223 0.064 0.1195
Leishmania major mitochondrial DNA topoisomerase II 0.01 0.0269 0.0484
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0156 0.1905
Echinococcus multilocularis neuropeptides capa receptor 0.0223 0.064 0.064
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0538 0.1584 0.2944
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0156 0.5299
Echinococcus multilocularis tar DNA binding protein 0.0125 0.0346 0.0346
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0156 0.0601
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0034 0.053
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0063
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0727 0.2152 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0062 0.0156 0.1905
Brugia malayi hypothetical protein 0.0011 0.0004 0.0007
Entamoeba histolytica DNA topoisomerase II, putative 0.01 0.0269 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0259 0.0484
Leishmania major heat shock protein 83-1 0.01 0.0269 0.0484
Toxoplasma gondii DNA topoisomerase 2, putative 0.01 0.0269 0.1135
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0156 0.0601
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0156 0.1905
Schistosoma mansoni hypothetical protein 0.0037 0.0082 0.0153
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0034 0.0063
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0034 0.0063
Plasmodium falciparum phosphodiesterase gamma, putative 0.0062 0.0156 0.5299
Onchocerca volvulus 0.0223 0.064 1
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0497 0.6377
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0044 0.0633
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0062 0.0156 0.1905
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0223 0.064 0.1195
Echinococcus multilocularis neuropeptide s receptor 0.0223 0.064 0.064
Loa Loa (eye worm) hypoxia-induced factor 1 0.0162 0.0458 0.0854
Giardia lamblia Pms1-like protein 0.01 0.0269 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0034 0.0063
Loa Loa (eye worm) CBP-B 0.0071 0.0184 0.0343
Brugia malayi Endoplasmin precursor 0.01 0.0269 0.0503
Brugia malayi G protein-coupled receptor F59B2.13 0.0223 0.064 0.1195
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0062 0.0156 0.1905
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0003 0.0005
Brugia malayi hypothetical protein 0.0176 0.0499 0.0931
Brugia malayi hypothetical protein 0.0223 0.064 0.1195
Echinococcus granulosus survival motor neuron protein 1 0.0255 0.0736 0.1374
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0148 0.4947
Schistosoma mansoni neuropeptide receptor 0.0223 0.064 0.1195
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0175 0.0326
Loa Loa (eye worm) endoplasmin 0.01 0.0269 0.0503
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0319 0.0596
Mycobacterium ulcerans DNA gyrase subunit B 0.01 0.0269 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.027 0.0503
Trypanosoma cruzi DNA topoisomerase II, putative 0.01 0.0269 0.0484
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0028 0.0053
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0062 0.0156 0.0291
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0034 0.0063
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0259 0.0484
Echinococcus granulosus fmrfamide receptor 0.0223 0.064 0.1195
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0156 0.0821
Schistosoma mansoni endoplasmin 0.01 0.0269 0.0503
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0156 0.0272
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0062 0.0156 0.0156
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0223 0.064 0.1195
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0223 0.064 0.1195
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0627 0.1853 0.3446
Echinococcus granulosus alpha 1A adrenergic receptor 0.0223 0.064 0.1195
Echinococcus multilocularis neuropeptide Y receptor 0.0223 0.064 0.064
Echinococcus multilocularis neuropeptide receptor A26 0.0223 0.064 0.064
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.0259 0.0484
Brugia malayi GnHR receptor homolog 0.0223 0.064 0.1195
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0034 0.0063
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0156 0.1905
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0156 0.0601
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Schistosoma mansoni myosin xvIII 0.0223 0.064 0.1195
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0063
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Brugia malayi Melatonin receptor type 1A 0.0223 0.064 0.1195
Onchocerca volvulus 0.0223 0.064 1
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0156 0.1905
Schistosoma mansoni cpg binding protein 0.0031 0.0064 0.012
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Echinococcus granulosus neuropeptides capa receptor 0.0223 0.064 0.1195
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0034 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0034 0.0063
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0223 0.064 0.1195
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0223 0.064 0.1195
Schistosoma mansoni opsin-like receptor 0.0223 0.064 0.1195
Trypanosoma brucei DNA topoisomerase ii 0.01 0.0269 0.0452
Onchocerca volvulus 0.0021 0.0034 0.053
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0017 0.0031
Schistosoma mansoni intermediate filament proteins 0.0029 0.0057 0.0107
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0259 0.0484
Echinococcus granulosus geminin 0.0335 0.0977 0.1825
Echinococcus granulosus cpg binding protein 0.0031 0.0064 0.012
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.01 0.0269 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0156 0.1905
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0034 0.007 0.0132
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0223 0.064 0.1195
Echinococcus multilocularis sex peptide receptor 0.0223 0.064 0.064
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0062 0.0156 0.1905
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0538 0.1584 0.7325
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0062 0.0156 0.0291
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Brugia malayi neuropeptide F receptor 0.0223 0.064 0.1195
Echinococcus granulosus tm gpcr rhodopsin 0.0223 0.064 0.1195
Schistosoma mansoni biogenic amine receptor 0.0223 0.064 0.1195
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0223 0.064 0.1195
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0044 0.0633
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0156 0.024
Trypanosoma brucei hypothetical protein, conserved 0.0062 0.0156 0.024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0259 0.0484
Echinococcus multilocularis CREB binding protein 0.007 0.0181 0.0181
Echinococcus multilocularis aryl hydrocarbon receptor 0.0014 0.0011 0.0011
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.1575 0.47 0.47
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0062 0.0156 0.0156
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0034 0.0063
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.01 0.0269 1
Echinococcus granulosus hypothetical protein 0.0223 0.064 0.1195
Treponema pallidum chemotaxis histidine kinase (cheA) 0.01 0.0269 1
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0538 0.1584 0.2944
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0627 0.1853 0.8589
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0034 0.0034
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0062 0.0156 0.1905
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.1575 0.47 0.8776
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0497 0.6377
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0538 0.1584 0.7325
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0062 0.0156 0.0291
Plasmodium falciparum heat shock protein 90 0.01 0.0269 1
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0017 0.0031
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0774 1
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.01 0.0269 0.0484
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0223 0.064 0.1195
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0223 0.064 0.1195
Echinococcus granulosus G protein coupled receptor 139 0.0223 0.064 0.1195
Brugia malayi putative neuropeptide receptor NPR1 0.0223 0.064 0.1195
Echinococcus granulosus dro:myosuppressin receptor 0.0223 0.064 0.1195
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0223 0.064 0.064
Leishmania major heat shock protein 83-1 0.01 0.0269 0.0484
Onchocerca volvulus 0.0052 0.0126 0.1969
Echinococcus granulosus DNA topoisomerase 2 alpha 0.01 0.0269 0.0503
Echinococcus multilocularis carbonic anhydrase 0.0034 0.007 0.007
Echinococcus multilocularis heat shock protein 90 0.01 0.0269 0.0269
Echinococcus granulosus rhodopsin orphan GPCR 0.0223 0.064 0.1195
Echinococcus granulosus CREB binding protein 0.0017 0.002 0.0038
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0526 0.6749
Schistosoma mansoni CREB-binding protein 2 0.0103 0.0278 0.0519
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0156 0.1905
Echinococcus multilocularis g-protein coupled receptor 0.0223 0.064 0.064
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0223 0.064 0.1195
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0034 0.0063
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Brugia malayi TAZ zinc finger family protein 0.0103 0.0278 0.0519
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0004 0.0004
Brugia malayi hypothetical protein 0.0223 0.064 0.1195
Brugia malayi neuropeptide F receptor 0.0223 0.064 0.1195
Trichomonas vaginalis DNA topoisomerase II, putative 0.01 0.0269 0.339
Echinococcus granulosus neuropeptide Y receptor 0.0223 0.064 0.1195
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0156 0.1905
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0034 0.0034
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0028 0.0053
Loa Loa (eye worm) hypothetical protein 0.0032 0.0065 0.0121
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0774 1
Onchocerca volvulus DNA topoisomerase 2 homolog 0.01 0.0269 0.4208
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0034 0.0063
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0319 0.0596
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0014 0.0011 0.002
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0062 0.0156 0.0272
Entamoeba histolytica hypothetical protein 0.0037 0.0082 0.2217
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.01 0.0269 0.0452
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0156 0.0601
Echinococcus multilocularis rhodopsin orphan GPCR 0.0223 0.064 0.064
Schistosoma mansoni hypothetical protein 0.0223 0.064 0.1195
Echinococcus granulosus heat shock protein 90 0.01 0.0269 0.0503
Schistosoma mansoni hypothetical protein 0.0032 0.0065 0.0121
Schistosoma mansoni hypothetical protein 0.0032 0.0065 0.0121
Brugia malayi larval opioid receptor 0.0223 0.064 0.1195
Trypanosoma brucei DNA topoisomerase II beta, putative 0.01 0.0269 0.0452
Echinococcus multilocularis dro:myosuppressin receptor 0.0223 0.064 0.064
Toxoplasma gondii hypothetical protein 0.0034 0.007 0.0199
Trypanosoma cruzi Heat shock protein 83, putative 0.01 0.0269 0.0484
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0062 0.0156 0.0291
Leishmania major heat shock protein 83-1 0.01 0.0269 0.0484
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0028 0.0033
Loa Loa (eye worm) hypothetical protein 0.0034 0.007 0.0132
Schistosoma mansoni biogenic amine (5HT) receptor 0.0223 0.064 0.1195
Echinococcus granulosus allatostatin A receptor 0.0223 0.064 0.1195
Echinococcus granulosus dnaJ subfamily B 0.0424 0.1243 0.2321
Schistosoma mansoni histamine h1 receptor 0.0223 0.064 0.1195
Echinococcus granulosus carbonic anhydrase 0.0034 0.007 0.0132
Mycobacterium ulcerans putative regultory protein 0.01 0.0269 1
Brugia malayi G-protein coupled receptor 0.0223 0.064 0.1195
Onchocerca volvulus 0.003 0.0059 0.0923
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0223 0.064 0.1195
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Entamoeba histolytica heat shock protein 90, putative 0.01 0.0269 1
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0113 0.031 1
Brugia malayi hypothetical protein 0.0223 0.064 0.1195
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0156 0.0601
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Trypanosoma brucei heat shock protein, putative 0.01 0.0269 0.0452
Schistosoma mansoni opsin-like receptor 0.0223 0.064 0.1195
Schistosoma mansoni pyruvate dehydrogenase 0.1694 0.5056 0.9441
Echinococcus granulosus CREB binding protein 0.0063 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0063
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0062 0.0156 0.1905
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0148 0.4947
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0034 0.0063
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0062 0.0156 0.0156
Onchocerca volvulus 0.0223 0.064 1
Echinococcus granulosus protein tyrosine kinase 0.017 0.048 0.0896
Trypanosoma brucei carbonic anhydrase-like protein 0.0147 0.0412 0.072
Brugia malayi hypothetical protein 0.0223 0.064 0.1195
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Echinococcus multilocularis carbonic anhydrase 0.0034 0.007 0.007
Leishmania major developmentally regulated phosphoprotein-like protein 0.1793 0.5356 1
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.01 0.0269 1
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0065 0.0121
Loa Loa (eye worm) hypothetical protein 0.0062 0.0156 0.0291
Onchocerca volvulus Neuropeptide F receptor homolog 0.0223 0.064 1
Toxoplasma gondii heat shock protein 90, putative 0.01 0.0269 0.1135
Plasmodium vivax DNA topoisomerase II, putative 0.01 0.0269 0.1549
Schistosoma mansoni carbonic anhydrase-related 0.0034 0.007 0.0132
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0497 0.6377
Brugia malayi steroid hormone receptor 0.0021 0.0034 0.0063
Loa Loa (eye worm) hypothetical protein 0.0255 0.0736 0.1374
Schistosoma mansoni amine GPCR 0.0223 0.064 0.1195
Giardia lamblia Hypothetical protein 0.0062 0.0156 0.5299
Echinococcus multilocularis neuropeptide receptor 0.0223 0.064 0.064
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0034 0.0063
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0259 0.0259
Schistosoma mansoni hypothetical protein 0.0223 0.064 0.1195
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0497 0.6377
Loa Loa (eye worm) heat shock protein 90 0.01 0.0269 0.0503
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0223 0.064 0.1195
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.01 0.0269 0.0503
Trypanosoma brucei heat shock protein, putative 0.01 0.0269 0.0452
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0259 0.0484
Echinococcus granulosus carbonic anhydrase 0.0034 0.007 0.0132
Entamoeba histolytica hypothetical protein 0.0037 0.0082 0.2217
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0156 0.0272
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0346 0.0647
Echinococcus granulosus biogenic amine 5HT receptor 0.0223 0.064 0.1195
Leishmania major carbonic anhydrase-like protein 0.0147 0.0412 0.075
Schistosoma mansoni carbonic anhydrase-related 0.0034 0.007 0.0132
Brugia malayi hypothetical protein 0.0037 0.0082 0.0153
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0627 0.1853 0.3446
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0062 0.0156 0.1905
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0223 0.064 0.1195
Brugia malayi nuclear receptor NHR-88 0.0021 0.0034 0.0063
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0223 0.064 0.1195
Echinococcus granulosus 7TM GPCR rhodopsin 0.0223 0.064 0.1195
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.1793 0.5356 0.5356
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0223 0.064 0.1195
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0223 0.064 0.1195
Schistosoma mansoni amine GPCR 0.0223 0.064 0.1195
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.027 0.0503
Echinococcus granulosus tachykinin peptides receptor 99D 0.0223 0.064 0.1195
Schistosoma mansoni lamin 0.0029 0.0057 0.0107
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0034 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0034 0.0063
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0062 0.0156 0.0272
Echinococcus multilocularis rhodopsin orphan GPCR 0.0223 0.064 0.064
Schistosoma mansoni neuropeptide f receptor 76f 0.0223 0.064 0.1195
Echinococcus granulosus tar DNA binding protein 0.0125 0.0346 0.0647
Echinococcus granulosus neuropeptides capa receptor 0.0223 0.064 0.1195
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0156 0.1905
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0156 0.5299
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0062 0.0156 0.1905
Leishmania major heat shock protein 83-1 0.01 0.0269 0.0484
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.0259 0.0484
Mycobacterium leprae Probable two component sensor kinase MprB 0.01 0.0269 1
Echinococcus granulosus carbonic anhydrase 0.0034 0.007 0.0132
Schistosoma mansoni hypothetical protein 0.0032 0.0065 0.0121
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0062 0.0156 0.1905
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0268 0.0774 0.1444
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0019
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0156 0.1905
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0223 0.064 0.064
Schistosoma mansoni hypothetical protein 0.0335 0.0977 0.1825
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0034 0.0063
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0268 0.0774 0.1444
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0062 0.0156 0.0272
Echinococcus granulosus g protein coupled receptor 0.0223 0.064 0.1195
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0062 0.0156 0.0272
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Onchocerca volvulus 0.0029 0.0057 0.0892
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.01 0.0269 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0156 0.0601
Trypanosoma brucei heat shock protein, putative 0.01 0.0269 0.0452
Leishmania major heat shock protein 83-1 0.01 0.0269 0.0484
Schistosoma mansoni cpg binding protein 0.0031 0.0064 0.012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0007
Loa Loa (eye worm) PDE1B protein 0.1575 0.47 0.8776
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0028 0.0033
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0034 0.0063
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0082 0.0153
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0223 0.064 0.064
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0774 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0156 0.0601
Leishmania major heat shock protein 83-1 0.01 0.0269 0.0484
Schistosoma mansoni biogenic amine receptor 0.0223 0.064 0.1195
Echinococcus multilocularis rhodopsin orphan GPCR 0.0223 0.064 0.064
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.01 0.0269 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0034 0.0063
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0223 0.064 0.064
Loa Loa (eye worm) hypothetical protein 0.0034 0.007 0.0132
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0034 0.0063
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0223 0.064 0.1195
Echinococcus multilocularis neuropeptide receptor 0.0223 0.064 0.064
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0062 0.0156 0.0821
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0004 0.0007
Leishmania major hypothetical protein, conserved 0.0062 0.0156 0.0272
Leishmania major heat shock protein 83-1 0.01 0.0269 0.0484
Schistosoma mansoni single-minded 0.0052 0.0127 0.0238
Brugia malayi heat shock protein 90 0.01 0.0269 0.0503
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Brugia malayi hypothetical protein 0.0223 0.064 0.1195
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.01 0.0269 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0034 0.0063
Loa Loa (eye worm) hypothetical protein 0.0034 0.007 0.0132
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0034 0.0034
Brugia malayi hypothetical protein 0.0223 0.064 0.1195
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Brugia malayi Protein kinase domain containing protein 0.0172 0.0486 0.0908
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0034 0.007 0.0132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0223 0.064 0.064
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0156 0.1905
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0156 0.1905
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0156 0.0601
Schistosoma mansoni pyruvate dehydrogenase 0.1694 0.5056 0.9441
Echinococcus granulosus neuropeptide receptor A26 0.0223 0.064 0.1195
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.01 0.0269 0.339
Echinococcus multilocularis carbonic anhydrase 0.0034 0.007 0.007
Echinococcus multilocularis g protein coupled receptor 0.0223 0.064 0.064
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0004 0.0007
Onchocerca volvulus 0.0039 0.0086 0.1349
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0223 0.064 0.1195
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0019
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0062 0.0156 0.0272
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0034 0.007 0.0132
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.1793 0.5356 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0159 0.0297
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0147 0.0412 0.075
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0223 0.064 1
Echinococcus granulosus tm gpcr rhodopsin 0.0223 0.064 0.1195
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0034 0.0063
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0004 0.0007
Brugia malayi Dopamine receptor protein 2 0.0223 0.064 0.1195
Leishmania major heat shock protein 83-1 0.01 0.0269 0.0484
Leishmania major hypothetical protein, conserved 0.0025 0.0044 0.0061
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0223 0.064 0.1195
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0148 0.4947
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0156 0.1905
Echinococcus multilocularis CREB binding protein 0.0017 0.002 0.002
Mycobacterium leprae Probable two-component sensor kinase 0.01 0.0269 1
Trypanosoma brucei heat shock protein, putative 0.01 0.0269 0.0452
Schistosoma mansoni ap endonuclease 0.0019 0.0028 0.0053
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0062 0.0156 0.0291
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0034 0.0063
Echinococcus multilocularis CREB binding protein 0.0017 0.002 0.002
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0538 0.1584 0.292
Onchocerca volvulus 0.0223 0.064 1
Onchocerca volvulus 0.0029 0.0057 0.0892
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0062 0.0156 0.0291
Leishmania major heat shock protein 83-1 0.01 0.0269 0.0484
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0148 0.4947
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0034 0.0063
Brugia malayi putative neuropeptide receptor 0.0223 0.064 0.1195
Giardia lamblia hypothetical protein 0.0062 0.0156 0.5299
Loa Loa (eye worm) hypothetical protein 0.0029 0.0057 0.0107
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0538 0.1584 0.2958
Loa Loa (eye worm) RNA binding protein 0.0125 0.0346 0.0647
Echinococcus multilocularis musashi 0.0029 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.01 0.027 0.0503
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0062 0.0156 0.1905
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0034 0.0063
Loa Loa (eye worm) melatonin receptor type 1A 0.0223 0.064 0.1195
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0156 0.1905
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Mycobacterium tuberculosis Possible two component sensor kinase 0.01 0.0269 1
Trypanosoma cruzi heat shock protein 90, putative 0.01 0.0269 0.0484
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0012 0.0022
Schistosoma mansoni hypothetical protein 0.0223 0.064 0.1195
Brugia malayi sulfakinin receptor protein 0.0223 0.064 0.1195
Trypanosoma brucei heat shock protein, putative 0.01 0.0269 0.0452
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0044 0.0061
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0223 0.064 0.064
Schistosoma mansoni neuropeptide receptor 0.0223 0.064 0.1195
Brugia malayi hypothetical protein 0.0016 0.0017 0.0032
Brugia malayi hypothetical protein 0.0255 0.0736 0.1374
Loa Loa (eye worm) hypothetical protein 0.0176 0.0499 0.0931
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.01 0.0269 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0028 0.0053
Echinococcus granulosus CREB binding protein 0.0017 0.002 0.0038
Echinococcus multilocularis rhodopsin orphan GPCR 0.0223 0.064 0.064
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0062 0.0156 0.1905
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0034 0.007 0.0132
Echinococcus multilocularis somatostatin receptor 0.0223 0.064 0.064
Onchocerca volvulus 0.0223 0.064 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0223 0.064 0.1195
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0156 0.0601
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0223 0.064 0.064
Trypanosoma brucei heat shock protein, putative 0.01 0.0269 0.0452
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0062 0.0156 0.0291
Schistosoma mansoni aryl hydrocarbon receptor 0.0052 0.0127 0.0238
Loa Loa (eye worm) TAR-binding protein 0.0125 0.0346 0.0647
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0062 0.0156 0.0291
Plasmodium vivax phosphodiesterase gamma, putative 0.0062 0.0156 0.0821
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0062 0.0156 0.0291
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0126 0.0235
Echinococcus granulosus serotonin receptor 0.0223 0.064 0.1195
Brugia malayi CXXC zinc finger family protein 0.003 0.0059 0.011
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0148 0.0256
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.01 0.0269 0.0484
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.0346 0.0647
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0223 0.064 0.064
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Loa Loa (eye worm) hypothetical protein 0.01 0.0269 0.0503
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0156 0.0601
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0497 0.6377
Trichomonas vaginalis receptor histidine kinase, putative 0.01 0.0269 0.339
Entamoeba histolytica heat shock protein 90, putative 0.01 0.0269 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0223 0.064 0.1195
Onchocerca volvulus 0.0223 0.064 1
Trypanosoma brucei heat shock protein, putative 0.01 0.0269 0.0452
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0223 0.064 0.1195
Loa Loa (eye worm) hypothetical protein 0.1793 0.5356 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0062 0.0156 0.5299
Leishmania major heat shock protein 83-1 0.01 0.0269 0.0484
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0148 0.0275
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0156 0.1905
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0044 0.0098
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.01 0.0269 0.1135
Trypanosoma brucei heat shock protein 90, putative 0.01 0.0269 0.0452
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.01 0.0269 1
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0156 0.0272
Schistosoma mansoni carbonic anhydrase 0.0034 0.007 0.0132
Plasmodium vivax hypothetical protein, conserved 0.01 0.0269 0.1549
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0082 0.0153
Echinococcus granulosus rhodopsin orphan GPCR 0.0223 0.064 0.1195
Leishmania major heat shock protein 83-1 0.01 0.0269 0.0484
Schistosoma mansoni neuropeptide receptor 0.0223 0.064 0.1195
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0062 0.0156 0.0291
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0062 0.0156 0.1905
Echinococcus multilocularis allatostatin A receptor 0.0223 0.064 0.064
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0538 0.1584 0.1584
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0003 0.0003
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0004 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0223 0.064 0.064
Plasmodium vivax DNA gyrase subunit B, putative 0.01 0.0269 0.1549
Echinococcus multilocularis lamin dm0 0.0029 0.0057 0.0057
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0034 0.0063
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0063
Brugia malayi AKH receptor 0.0223 0.064 0.1195
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0034 0.007 0.0132
Echinococcus granulosus neuropeptide Y receptor 0.0223 0.064 0.1195
Schistosoma mansoni carbonic anhydrase-related 0.0034 0.007 0.0132
Echinococcus granulosus tm gpcr rhodopsin 0.0223 0.064 0.1195
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0062 0.0156 0.5299
Echinococcus granulosus neuropeptide s receptor 0.0223 0.064 0.1195
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0223 0.064 0.064
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.01 0.0269 0.339
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0223 0.064 0.064
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0034 0.0034
Trypanosoma cruzi heat shock protein 85, putative 0.01 0.0269 0.0484
Echinococcus multilocularis fmrfamide receptor 0.0223 0.064 0.064
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0057 0.0107
Trypanosoma brucei developmentally regulated phosphoprotein 0.1793 0.5356 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.1575 0.47 0.8776
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0034 0.0063
Brugia malayi G-protein coupled receptor 0.0223 0.064 0.1195
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.01 0.0269 0.339
Echinococcus granulosus lamin 0.0029 0.0057 0.0107
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0062 0.0156 0.1905
Brugia malayi kinase, mitochondrial precursor 0.1793 0.5356 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0147 0.0412 0.0769
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0022
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0223 0.064 0.064
Leishmania major heat shock protein 83-1 0.01 0.0269 0.0484
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0034 0.0063
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.01 0.0269 0.0269
Schistosoma mansoni amine GPCR 0.0223 0.064 0.1195
Onchocerca volvulus 0.0014 0.0011 0.0167
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Echinococcus granulosus g-protein coupled receptor 0.0223 0.064 0.1195
Leishmania major heat shock protein 83-1 0.01 0.0269 0.0484
Echinococcus granulosus neuropeptide FF receptor 2 0.0223 0.064 0.1195
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0062 0.0156 0.0156
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0062 0.0156 0.1905
Schistosoma mansoni cpg binding protein 0.003 0.0059 0.011
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0086 0.0086
Brugia malayi hypothetical protein 0.0223 0.064 0.1195
Onchocerca volvulus 0.0223 0.064 1
Schistosoma mansoni hypothetical protein 0.0424 0.1243 0.2321
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0526 0.6749
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0156 0.1905
Schistosoma mansoni heat shock protein 0.01 0.0269 0.0503
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0223 0.064 0.064
Loa Loa (eye worm) TOPoisomerase family member 0.01 0.0269 0.0503
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0156 0.1905
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0148 0.0275
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Trichomonas vaginalis heat shock protein, putative 0.01 0.0269 0.339
Loa Loa (eye worm) neuropeptide F receptor 0.0223 0.064 0.1195
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.01 0.0269 0.0484
Brugia malayi hypothetical protein 0.0223 0.064 0.1195
Schistosoma mansoni coup transcription factor 0.0021 0.0034 0.0063
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0057 0.0107
Plasmodium falciparum DNA topoisomerase 2 0.01 0.0269 1
Echinococcus multilocularis g protein coupled receptor 0.0223 0.064 0.064
Trypanosoma brucei heat shock protein, putative 0.01 0.0269 0.0452
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0004 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0034 0.0063
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0034 0.0034
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.01 0.0269 1
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.01 0.0269 1
Leishmania major hypothetical protein, conserved 0.01 0.0269 0.0484
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0034 0.0063
Loa Loa (eye worm) hypothetical protein 0.0025 0.0044 0.0081
Echinococcus multilocularis GPCR, family 2 0.0032 0.0065 0.0065
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0065 0.0121
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Schistosoma mansoni adenoreceptor 0.0223 0.064 0.1195
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0497 0.6377
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.1793 0.5356 0.5356
Brugia malayi nuclear hormone receptor 0.0021 0.0034 0.0063
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0034 0.053
Entamoeba histolytica hypothetical protein 0.0037 0.0082 0.2217
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0028 0.023
Echinococcus multilocularis G-protein coupled receptor, putative 0.0223 0.064 0.064
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0034 0.0063
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0012 0.0012
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0223 0.064 0.1195
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0065 0.0121
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0034 0.0063
Onchocerca volvulus DNA topoisomerase 2 homolog 0.01 0.0269 0.4208
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0223 0.064 0.1195
Schistosoma mansoni hypothetical protein 0.0052 0.0126 0.0235
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Brugia malayi hypoxia-induced factor 1 0.0162 0.0458 0.0854
Echinococcus multilocularis neuropeptide FF receptor 2 0.0223 0.064 0.064
Trichomonas vaginalis endoplasmin, putative 0.01 0.0269 0.339
Brugia malayi hypothetical protein 0.0223 0.064 0.1195
Trypanosoma cruzi heat shock protein 85, putative 0.01 0.0269 0.0484
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0156 0.1905
Leishmania major heat shock protein 83-1 0.01 0.0269 0.0484
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0062 0.0156 0.0291
Loa Loa (eye worm) hypothetical protein 0.01 0.0269 0.0503
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0034 0.007 0.0132
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0034 0.0063
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0034 0.0063
Leishmania major hypothetical protein, conserved 0.0062 0.0156 0.0272
Brugia malayi hypothetical protein 0.0025 0.0044 0.0081
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Schistosoma mansoni lamin 0.0029 0.0057 0.0107
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0062 0.0156 0.5299
Echinococcus multilocularis lamin 0.0029 0.0057 0.0057
Schistosoma mansoni endoplasmin 0.01 0.0269 0.0503
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0062 0.0156 0.0291
Echinococcus granulosus rhodopsin orphan GPCR 0.0223 0.064 0.1195
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0065 0.0121
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0014 0.0011 0.0011
Brugia malayi intermediate filament protein 0.0029 0.0057 0.0107
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.01 0.0269 0.339
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.1793 0.5356 1
Plasmodium falciparum carbonic anhydrase 0.0034 0.007 0.1752
Schistosoma mansoni hypothetical protein 0.0011 0.0003 0.0005
Loa Loa (eye worm) G-protein coupled receptor 0.0223 0.064 0.1195
Echinococcus granulosus rhodopsin orphan GPCR 0.0223 0.064 0.1195
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.01 0.0269 0.1135
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.01 0.0269 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0063
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0062 0.0156 0.0291
Onchocerca volvulus 0.0223 0.064 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0223 0.064 0.1195
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.01 0.0269 0.339
Plasmodium falciparum phosphodiesterase delta, putative 0.0062 0.0156 0.5299
Brugia malayi MH2 domain containing protein 0.0116 0.0319 0.0596
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.1575 0.47 0.8776
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0014 0.0011 0.002
Echinococcus granulosus g protein coupled receptor 0.0223 0.064 0.1195
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0062 0.0156 0.0272
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0034 0.0063
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0156 0.0272
Loa Loa (eye worm) TYRA-2 protein 0.0223 0.064 0.1195
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0156 0.0601
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.01 0.0269 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0034 0.0034
Echinococcus granulosus rhodopsin orphan GPCR 0.0223 0.064 0.1195
Echinococcus multilocularis cpg binding protein 0.0031 0.0064 0.0064
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0034 0.0063
Schistosoma mansoni hypothetical protein 0.0034 0.007 0.0132
Echinococcus multilocularis neuropeptides capa receptor 0.0223 0.064 0.064
Echinococcus multilocularis serotonin receptor 0.0223 0.064 0.064
Loa Loa (eye worm) hypothetical protein 0.0048 0.0114 0.0214
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0156 0.1905
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0223 0.064 0.1195
Echinococcus multilocularis heat shock protein 0.01 0.0269 0.0269
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0774 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0148 0.0148
Schistosoma mansoni growth hormone secretagogue receptor 0.0223 0.064 0.1195
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0034 0.0063
Loa Loa (eye worm) hypothetical protein 0.0068 0.0175 0.0326
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0062 0.0156 0.0291
Echinococcus multilocularis survival motor neuron protein 1 0.0255 0.0736 0.0736
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0062 0.0156 0.0291
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0156 0.1905
Leishmania major DNA topoisomerase ii 0.01 0.0269 0.0484
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0223 0.064 0.064
Echinococcus multilocularis CREB binding protein 0.0017 0.002 0.002
Echinococcus granulosus orexin receptor type 2 0.0223 0.064 0.1195
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.01 0.0269 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0028 0.0028
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0147 0.0412 0.0769
Schistosoma mansoni hypothetical protein 0.0335 0.0977 0.1825
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Brugia malayi G protein-coupled receptor 0.0223 0.064 0.1195
Schistosoma mansoni alpha-1 adrenergic receptor 0.0223 0.064 0.1195
Leishmania major cAMP-specific phosphodiesterase, putative 0.0062 0.0156 0.0272
Plasmodium vivax heat shock protein 86, putative 0.01 0.0269 0.1549
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0156 0.0272
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0062 0.0156 0.0156
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0062 0.0156 0.1905
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0057 0.0107
Onchocerca volvulus 0.0223 0.064 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0034 0.0034
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0144 0.0547
Brugia malayi DNA topoisomerase II, alpha isozyme 0.01 0.0269 0.0503
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0223 0.064 0.1195
Giardia lamblia Heat shock protein HSP 90-alpha 0.01 0.0269 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0223 0.064 0.1195
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0774 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0034 0.0063
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Echinococcus multilocularis geminin 0.0335 0.0977 0.0977
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0062 0.0156 0.0156
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0156 0.1905
Schistosoma mansoni hypothetical protein 0.0223 0.064 0.1195
Echinococcus granulosus 7tm_1 domain containing protein 0.0223 0.064 0.1195
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0223 0.064 0.1195
Toxoplasma gondii heat shock protein HSP90 0.01 0.0269 0.1135
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0062 0.0156 0.1905
Schistosoma mansoni neuropeptide receptor 0.0223 0.064 0.1195
Mycobacterium tuberculosis Conserved protein 0.01 0.0269 1
Trypanosoma brucei heat shock protein 90, putative 0.01 0.0269 0.0452
Brugia malayi nuclear receptor RXR 0.0011 0.0004 0.0007
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.01 0.0269 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0223 0.064 0.064
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0148 0.0275
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0156 0.1905
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0034 0.0063
Onchocerca volvulus 0.0223 0.064 1
Echinococcus granulosus neuropeptide receptor 0.0223 0.064 0.1195
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0156 0.024
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0063
Schistosoma mansoni pyruvate dehydrogenase 0.1793 0.5356 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0156 0.1905
Echinococcus granulosus somatostatin receptor 0.0223 0.064 0.1195
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0086 0.2411
Mycobacterium tuberculosis Probable sensor protein KdpD 0.01 0.0269 1
Onchocerca volvulus Glucosylceramidase homolog 0.0176 0.0497 0.7767
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0156 0.1905
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0063
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0223 0.064 0.1195
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0034 0.0063
Onchocerca volvulus 0.0223 0.064 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0538 0.1584 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0007
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0086 0.0161
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0148 0.0562
Mycobacterium ulcerans two component sensor kinase MprB 0.01 0.0269 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0034 0.053
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0346 0.0647
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0156 0.1905
Echinococcus multilocularis neuropeptide Y receptor 0.0223 0.064 0.064
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Trypanosoma cruzi heat shock protein 90, putative 0.01 0.0269 0.0484
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0346 0.0647
Onchocerca volvulus 0.0223 0.064 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0007
Onchocerca volvulus 0.0223 0.064 1
Echinococcus multilocularis G protein coupled receptor 139 0.0223 0.064 0.064
Echinococcus granulosus lamin dm0 0.0029 0.0057 0.0107
Brugia malayi hypothetical protein 0.0011 0.0004 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0034 0.0063
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.01 0.0269 1
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.01 0.0269 1
Schistosoma mansoni neuropeptide F-like receptor 0.0223 0.064 0.1195
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0059 0.011
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0774 1
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0346 0.0647
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0156 0.1905
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.01 0.0269 1
Onchocerca volvulus 0.0223 0.064 1
Brugia malayi PAS domain containing protein 0.0052 0.0127 0.0238
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0065 0.0121
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0223 0.064 0.064
Echinococcus granulosus neuropeptide receptor 0.0223 0.064 0.1195
Echinococcus granulosus biogenic amine 5HT receptor 0.0223 0.064 0.1195
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0034 0.0063
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0062 0.0156 0.0291
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0223 0.064 0.1195
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0223 0.064 0.064
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0223 0.064 0.1195
Plasmodium falciparum endoplasmin, putative 0.01 0.0269 1
Echinococcus granulosus aryl hydrocarbon receptor 0.0014 0.0011 0.002
Loa Loa (eye worm) hypothetical protein 0.0062 0.0156 0.0291
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.01 0.0269 0.4208
Echinococcus granulosus single minded 2 0.0039 0.0086 0.0161
Brugia malayi Tachykinin-like peptides receptor 99D 0.0223 0.064 0.1195
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0062 0.0156 0.0291
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0223 0.064 0.064
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0223 0.064 0.1195
Mycobacterium tuberculosis Probable two component sensor kinase 0.01 0.0269 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0034 0.0063
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.01 0.0269 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0156 0.0601
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0062 0.0156 0.0291
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0147 0.0412 0.0769
Echinococcus granulosus heat shock protein 0.01 0.0269 0.0503
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.01 0.0269 1
Loa Loa (eye worm) TK/FAK protein kinase 0.0172 0.0486 0.0908
Brugia malayi hypothetical protein 0.0223 0.064 0.1195
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0062 0.0156 0.0291
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.027 0.0503

Activities

Activity type Activity value Assay description Source Reference
Kd (binding) = 140 nM Dissociation constant against human carbonic anhydrase II at 37 degree centigrade ChEMBL. No reference
Kd (binding) = 140 nM Dissociation constant against human carbonic anhydrase II at 37 degree centigrade ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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