Detailed information for compound 269531

Basic information

Technical information
  • TDR Targets ID: 269531
  • Name: (2R)-N-[(2S)-3,3-dimethyl-1-oxo-1-pyridin-2-y lbutan-2-yl]-2-[[formyl(hydroxy)amino]methyl] hexanamide
  • MW: 363.451 | Formula: C19H29N3O4
  • H donors: 2 H acceptors: 5 LogP: 3.49 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC[C@@H](C(=O)N[C@@H](C(C)(C)C)C(=O)c1ccccn1)CN(C=O)O
  • InChi: 1S/C19H29N3O4/c1-5-6-9-14(12-22(26)13-23)18(25)21-17(19(2,3)4)16(24)15-10-7-8-11-20-15/h7-8,10-11,13-14,17,26H,5-6,9,12H2,1-4H3,(H,21,25)/t14-,17-/m1/s1
  • InChiKey: NGFKLEMUGMVHAI-RHSMWYFYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2R)-N-[(1S)-2,2-dimethyl-1-(pyridine-2-carbonyl)propyl]-2-[[formyl(hydroxy)amino]methyl]hexanamide
  • (2R)-N-[(1S)-2,2-dimethyl-1-[oxo(2-pyridyl)methyl]propyl]-2-[[formyl(hydroxy)amino]methyl]hexanamide
  • (2R)-N-[(2S)-3,3-dimethyl-1-oxo-1-pyridin-2-yl-butan-2-yl]-2-[[hydroxy(methanoyl)amino]methyl]hexanamide
  • (2R)-N-[(1S)-2,2-dimethyl-1-picolinoyl-propyl]-2-[[formyl(hydroxy)amino]methyl]hexanamide
  • (2R)-N-[(2S)-3,3-dimethyl-1-oxo-1-pyridin-2-ylbutan-2-yl]-2-[(formyl-hydroxyamino)methyl]hexanamide
  • (2R)-N-[(1S)-2,2-dimethyl-1-(pyridine-2-carbonyl)propyl]-2-[(formyl-hydroxy-amino)methyl]hexanamide
  • (2R)-N-[(1S)-2,2-dimethyl-1-[oxo-(2-pyridyl)methyl]propyl]-2-[(formyl-hydroxyamino)methyl]hexanamide
  • (2R)-N-[(2S)-3,3-dimethyl-1-oxo-1-pyridin-2-yl-butan-2-yl]-2-[(hydroxy-methanoyl-amino)methyl]hexanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli peptide deformylase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
Mycobacterium ulcerans peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium yoelii polypeptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium knowlesi peptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) Get druggable targets OG5_128237 All targets in OG5_128237
Wolbachia endosymbiont of Brugia malayi peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
Chlamydia trachomatis peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium vivax peptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
Treponema pallidum polypeptide deformylase (def) Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium berghei peptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) Get druggable targets OG5_128237 All targets in OG5_128237
Neospora caninum Peptide deformylase, related Get druggable targets OG5_128237 All targets in OG5_128237
Toxoplasma gondii hypothetical protein Get druggable targets OG5_128237 All targets in OG5_128237
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0026 0.0336 0.0959
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.195 0.195
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0545 0.0799
Onchocerca volvulus 0.0034 0.0516 0.1513
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0071 0.1445 0.1445
Schistosoma mansoni hypothetical protein 0.0062 0.1202 0.118
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.016 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0516 0.0943
Loa Loa (eye worm) hypothetical protein 0.0071 0.1445 0.2641
Echinococcus multilocularis dnaJ subfamily B 0.0419 1 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0206 0.0206
Schistosoma mansoni retinoic acid receptor RXR 0.0071 0.1445 0.1424
Brugia malayi ecdysone receptor 0.0034 0.0516 0.0903
Loa Loa (eye worm) hypothetical protein 0.0118 0.2598 0.4748
Loa Loa (eye worm) hypothetical protein 0.0047 0.0836 0.1527
Schistosoma mansoni lamin 0.0026 0.0336 0.0313
Brugia malayi nuclear receptor NHR-88 0.0034 0.0516 0.0903
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0336 0.0614
Loa Loa (eye worm) hypothetical protein 0.0071 0.1445 0.2641
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0026 0.0334 0.0334
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0062 0.1202 0.2162
Echinococcus granulosus Smad4 0.0016 0.0081 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0071 0.1445 0.2608
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0071 0.1445 0.4368
Brugia malayi Ets-domain containing protein 0.0071 0.1445 0.2608
Brugia malayi Carboxylesterase family protein 0.0071 0.144 0.26
Loa Loa (eye worm) hypothetical protein 0.0047 0.0836 0.1527
Treponema pallidum polypeptide deformylase (def) 0.0279 0.6545 0.5
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0498 0.0727
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0498 0.0727
Echinococcus granulosus acetylcholinesterase 0.0071 0.144 0.144
Loa Loa (eye worm) histone methyltransferase 0.0026 0.0334 0.0609
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0516 0.0493
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0062 0.1202 0.1202
Brugia malayi nuclear hormone receptor family member odr-7 0.0034 0.0516 0.0903
Echinococcus granulosus lamin dm0 0.0026 0.0336 0.0336
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0516 0.0903
Trypanosoma cruzi Peptide deformylase 2, putative 0.0106 0.2303 1
Brugia malayi nuclear receptor RXR 0.0034 0.0516 0.0903
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0071 0.1445 0.1445
Loa Loa (eye worm) DR-78 0.0034 0.0516 0.0943
Brugia malayi hypothetical protein 0.0118 0.2598 0.4725
Loa Loa (eye worm) hypothetical protein 0.0034 0.0516 0.0943
Loa Loa (eye worm) hypothetical protein 0.0062 0.1202 0.2196
Echinococcus granulosus smad 0.0016 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0035 0.0545 0.0996
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0836 0.1245
Loa Loa (eye worm) hypothetical protein 0.0038 0.0616 0.1125
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0044
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0322 0.0457
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0592
Brugia malayi Steroid receptor seven-up type 2 0.0071 0.1445 0.2608
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0836 0.1245
Schistosoma mansoni steroid hormone receptor ad4bp 0.0071 0.1445 0.1424
Loa Loa (eye worm) hypothetical protein 0.0061 0.119 0.2174
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0322 0.1308
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0836 0.1245
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0836 0.1245
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0024 0.0024
Echinococcus multilocularis acetylcholinesterase 0.0071 0.144 0.144
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0516 0.0903
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0071 0.1445 0.2641
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0071 0.1445 0.2608
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0836 0.149
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0106 0.2303 1
Onchocerca volvulus Huntingtin homolog 0.0118 0.2598 0.7911
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0081 0.0081
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0516 0.0516
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0034 0.0063
Toxoplasma gondii hypothetical protein 0.0279 0.6545 1
Plasmodium vivax peptide deformylase, putative 0.0279 0.6545 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0062 0.1202 0.2196
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.195 0.195
Schistosoma mansoni nuclear receptor 0.0034 0.0516 0.0493
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0071 0.1445 0.1424
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.1445 0.1445
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0071 0.1445 0.2641
Brugia malayi tailless protein 0.0034 0.0516 0.0903
Brugia malayi hypothetical protein 0.0034 0.0516 0.0903
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0516 0.0493
Echinococcus multilocularis FTZ F1 alpha 0.0071 0.1445 0.1445
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0106 0.2303 1
Brugia malayi Fli-1 protein 0.0217 0.5024 0.9177
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.016 1
Loa Loa (eye worm) hypothetical protein 0.0118 0.2598 0.4748
Brugia malayi orphan nuclear receptor NR2E1 0.0034 0.0516 0.0903
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0034 0.0516 0.0493
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.016 1
Echinococcus multilocularis lamin dm0 0.0026 0.0336 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0071 0.1445 0.2608
Brugia malayi hypothetical protein 0.0034 0.0516 0.0903
Echinococcus multilocularis Smad4 0.0016 0.0081 0.0081
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.016 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0322 0.1308
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.195 0.195
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.195 0.1931
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0071 0.1445 0.1424
Echinococcus granulosus carboxylesterase 5A 0.0071 0.144 0.144
Loa Loa (eye worm) hypothetical protein 0.0071 0.1445 0.2641
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0071 0.1445 0.2608
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.016 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0071 0.1445 0.2641
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0336 0.0573
Loa Loa (eye worm) acetylcholinesterase 1 0.0071 0.144 0.2632
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0836 1
Brugia malayi hypothetical protein 0.0038 0.0616 0.1086
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0516 0.0516
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0322 0.0457
Loa Loa (eye worm) hypothetical protein 0.0034 0.0516 0.0943
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0322 0.1308
Brugia malayi conserved hypotetical protein 0.0034 0.0516 0.0903
Schistosoma mansoni nuclear receptor nhr-48 0.0034 0.0516 0.0493
Echinococcus multilocularis acetylcholinesterase 0.0071 0.144 0.144
Brugia malayi nuclear receptor NHR-88 0.0071 0.1445 0.2608
Schistosoma mansoni nuclear hormone receptor 0.0071 0.1445 0.1424
Brugia malayi latrophilin 2 splice variant baaae 0.0133 0.296 0.5389
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.016 1
Schistosoma mansoni RAR-like nuclear receptor 0.0071 0.1445 0.1424
Echinococcus multilocularis GPCR, family 2 0.0062 0.1202 0.1202
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0034 0.0516 0.0516
Echinococcus granulosus cpg binding protein 0.009 0.1897 0.1897
Echinococcus granulosus lamin 0.0026 0.0336 0.0336
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0038 0.0616 0.1125
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0836 0.1245
Brugia malayi Ets-domain containing protein 0.0071 0.1445 0.2608
Echinococcus granulosus acetylcholinesterase 0.0071 0.144 0.144
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.195 0.1931
Brugia malayi Nuclear hormone receptor-like 1 0.0071 0.1445 0.2608
Echinococcus granulosus GPCR family 2 0.0062 0.1202 0.1202
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0836 0.1245
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0498 0.0727
Trypanosoma brucei Polypeptide deformylase 1 0.0106 0.2303 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0516 0.0943
Onchocerca volvulus 0.0034 0.0516 0.1513
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0836 0.356
Loa Loa (eye worm) hypothetical protein 0.0071 0.144 0.2632
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0836 0.1245
Loa Loa (eye worm) hypothetical protein 0.0035 0.0545 0.0996
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.1445 0.264
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0836 0.356
Brugia malayi nuclear receptor NHR-67 0.0034 0.0516 0.0903
Brugia malayi nuclear hormone receptor 0.0034 0.0516 0.0903
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.016 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0071 0.1445 0.2608
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0071 0.1445 0.1445
Loa Loa (eye worm) hypothetical protein 0.0026 0.0322 0.0589
Echinococcus multilocularis geminin 0.0167 0.38 0.38
Schistosoma mansoni smad1 5 8 and 0.0016 0.0081 0.0057
Loa Loa (eye worm) hypothetical protein 0.0038 0.0616 0.1125
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0024 0.0024
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0071 0.1445 0.2608
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0195 0.4475 0.8177
Echinococcus multilocularis thyroid hormone receptor alpha 0.0071 0.1445 0.1445
Onchocerca volvulus 0.0071 0.1445 0.4368
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0071 0.1445 0.2641
Schistosoma mansoni cpg binding protein 0.009 0.1897 0.1877
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0071 0.1445 0.2608
Echinococcus granulosus nuclear receptor nhr 48 0.0034 0.0516 0.0516
Brugia malayi CXXC zinc finger family protein 0.0085 0.1777 0.3219
Loa Loa (eye worm) nuclear hormone receptor 0.0034 0.0516 0.0943
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0545 0.0799
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0024 0.0044
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0206 0.0206
Onchocerca volvulus Protein ultraspiracle homolog 0.0071 0.1445 0.4368
Trypanosoma brucei Peptide deformylase 2 0.0106 0.2303 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0062 0.1202 0.1202
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0836 0.1245
Echinococcus granulosus intermediate filament protein 0.0026 0.0336 0.0336
Brugia malayi Carboxylesterase family protein 0.0071 0.144 0.26
Brugia malayi Smad1 0.0016 0.0081 0.0104
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0279 0.6545 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0034 0.0516 0.0493
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0516 0.0516
Loa Loa (eye worm) hypothetical protein 0.0038 0.0616 0.1125
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0071 0.1445 0.2608
Loa Loa (eye worm) hypothetical protein 0.0038 0.0616 0.1125
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0071 0.1445 0.1445
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.195 0.1931
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0616 0.1086
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0071 0.1445 0.1445
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0044
Loa Loa (eye worm) CXXC zinc finger family protein 0.0085 0.1777 0.3248
Brugia malayi hypothetical protein 0.0017 0.0097 0.0134
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.195 0.3564
Schistosoma mansoni hypothetical protein 0.0062 0.1202 0.118
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0038 0.0616 0.0593
Loa Loa (eye worm) Smad1 0.0016 0.0081 0.0148
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0516 0.0516
Loa Loa (eye worm) nuclear receptor NHR-67 0.0034 0.0516 0.0943
Toxoplasma gondii histone lysine methyltransferase SET1 0.0161 0.3648 0.5557
Brugia malayi MH2 domain containing protein 0.0016 0.0081 0.0104
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0071 0.1445 0.1445
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.195 0.195
Onchocerca volvulus 0.0146 0.3278 1
Brugia malayi hypothetical protein 0.0038 0.0616 0.1086
Schistosoma mansoni intermediate filament proteins 0.0026 0.0336 0.0313
Schistosoma mansoni thyroid hormone receptor 0.0071 0.1445 0.1424
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0034 0.0516 0.0516
Brugia malayi Latrophilin receptor protein 2 0.0062 0.1202 0.2162
Schistosoma mansoni zinc finger protein 0.0034 0.0516 0.0493
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0071 0.1445 0.1445
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0836 0.149
Loa Loa (eye worm) hypothetical protein 0.0026 0.0336 0.0614
Echinococcus multilocularis ecdysone induced protein 78C 0.0071 0.1445 0.1445
Echinococcus granulosus geminin 0.0167 0.38 0.38
Loa Loa (eye worm) hypothetical protein 0.0034 0.0516 0.0943
Schistosoma mansoni smad 0.0016 0.0081 0.0057
Onchocerca volvulus 0.0085 0.1777 0.5389
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.195 0.3536
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0081 0.0081
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0034 0.0019
Brugia malayi Calcitonin receptor-like protein seb-1 0.0195 0.4475 0.8169
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0616 0.0593
Echinococcus granulosus ecdysone induced protein 78C 0.0071 0.1445 0.1445
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0836 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0516 0.0943
Brugia malayi intermediate filament protein 0.0026 0.0336 0.0573
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0279 0.6545 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.3278 0.599
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.016 1
Trypanosoma cruzi Peptide deformylase 2, putative 0.0106 0.2303 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0081 0.0148
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0322 0.0457
Brugia malayi hypothetical protein 0.0026 0.0322 0.0547
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0081 0.0057
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0034 0.0516 0.0943
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.016 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0062 0.1202 0.1202
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0071 0.1445 0.1424
Brugia malayi MH2 domain containing protein 0.0235 0.5472 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.016 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0071 0.1445 0.2641
Schistosoma mansoni hypothetical protein 0.0133 0.296 0.2943
Echinococcus multilocularis cpg binding protein 0.009 0.1897 0.1897
Loa Loa (eye worm) hypothetical protein 0.0034 0.0516 0.0943
Schistosoma mansoni mixed-lineage leukemia protein mll 0.018 0.4121 0.4107
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0026 0.0334 0.0334
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0516 0.0516
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0545 0.0799
Chlamydia trachomatis peptide deformylase 0.0279 0.6545 1
Brugia malayi MH1 domain containing protein 0.0016 0.0081 0.0104
Loa Loa (eye worm) hypothetical protein 0.0133 0.296 0.5409
Brugia malayi nuclear receptor RXR 0.0038 0.0616 0.1086
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0071 0.1445 0.1424
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0021 0.0206 0.0206
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.0516 0.1513
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0071 0.1445 0.2641
Echinococcus multilocularis musashi 0.0026 0.0336 0.0336
Brugia malayi ecdysteroid receptor 0.0071 0.1445 0.2608
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0836 0.1245
Schistosoma mansoni hypothetical protein 0.0419 1 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0081 0.0057
Schistosoma mansoni gabp alpha 0.0071 0.1445 0.1424
Echinococcus multilocularis carboxylesterase 5A 0.0071 0.144 0.144
Schistosoma mansoni Smad4 0.0016 0.0081 0.0057
Loa Loa (eye worm) steroid hormone receptor 0.0071 0.1445 0.2641
Schistosoma mansoni thyroid hormone receptor 0.0071 0.1445 0.1424
Echinococcus granulosus thyroid hormone receptor alpha 0.0034 0.0516 0.0516
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0279 0.6545 0.5
Loa Loa (eye worm) hypothetical protein 0.0071 0.1445 0.2641
Onchocerca volvulus Bile acid receptor homolog 0.0071 0.1445 0.4368
Trichomonas vaginalis helicase, putative 0.0019 0.016 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.1445 0.2641
Loa Loa (eye worm) hypothetical protein 0.0071 0.1445 0.2641
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.016 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0071 0.1445 0.2608
Loa Loa (eye worm) MH2 domain-containing protein 0.0235 0.5472 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0836 0.1527
Loa Loa (eye worm) hypothetical protein 0.0071 0.1445 0.2641
Schistosoma mansoni hypothetical protein 0.0062 0.1202 0.118
Echinococcus multilocularis nuclear receptor nhr 48 0.0034 0.0516 0.0516
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0545 0.0799
Brugia malayi MH2 domain containing protein 0.0016 0.0081 0.0104
Loa Loa (eye worm) carboxylesterase 0.0071 0.144 0.2632
Loa Loa (eye worm) hypothetical protein 0.0034 0.0516 0.0943
Brugia malayi photoreceptor-specific nuclear receptor 0.0071 0.1445 0.2608
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.016 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0545 0.0996
Loa Loa (eye worm) hypothetical protein 0.0195 0.4475 0.8177
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0206 0.0183
Brugia malayi nuclear hormone receptor family member nhr-6 0.0034 0.0516 0.0903
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0071 0.1445 0.2608
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.016 1
Brugia malayi F/Y-rich N-terminus family protein 0.0026 0.0325 0.0553
Brugia malayi hypothetical protein 0.0146 0.3278 0.5972
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0034 0.0516 0.0903
Schistosoma mansoni hypothetical protein 0.0167 0.38 0.3785
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0071 0.1445 0.1445
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0071 0.1445 0.2641
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0071 0.1445 0.1445
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0616 0.1086
Leishmania major hypothetical protein, conserved 0.0026 0.0322 0.1308
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0038 0.0616 0.0616
Loa Loa (eye worm) fli-1 protein 0.0217 0.5024 0.9181
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0071 0.1445 0.1445
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0071 0.144 0.142
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0322 0.0457
Schistosoma mansoni coup transcription factor 0.0071 0.1445 0.1424
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0071 0.1445 0.1445
Brugia malayi steroid hormone receptor 0.0071 0.1445 0.2608
Loa Loa (eye worm) hypothetical protein 0.0038 0.0616 0.1125
Echinococcus granulosus FTZ F1 alpha 0.0071 0.1445 0.1445
Loa Loa (eye worm) transcription factor SMAD2 0.0235 0.5472 1
Onchocerca volvulus 0.0047 0.0836 0.2494
Loa Loa (eye worm) oxidoreductase 0.0014 0.0024 0.0044
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0836 0.1245
Loa Loa (eye worm) hypothetical protein 0.0035 0.0545 0.0996
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.016 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0024 0.0044
Loa Loa (eye worm) hypothetical protein 0.0035 0.0545 0.0996
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0836 0.356
Schistosoma mansoni lamin 0.0026 0.0336 0.0313
Echinococcus granulosus mixed lineage leukemia protein mll 0.0021 0.0206 0.0206
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0071 0.1445 0.1445
Loa Loa (eye worm) hypothetical protein 0.0034 0.0516 0.0943
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0071 0.1445 0.1445
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0071 0.1445 0.2608
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0071 0.1445 0.2608
Brugia malayi MH1 domain containing protein 0.0016 0.0081 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0071 0.1445 0.2608
Mycobacterium ulcerans hypothetical protein 0.0047 0.0836 0.1245
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0195 0.4475 0.8169
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0498 0.0727
Leishmania major polypeptide deformylase-like protein, putative 0.0106 0.2303 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.144 0.2632
Plasmodium falciparum peptide deformylase 0.0279 0.6545 1
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.1445 0.1445
Brugia malayi nuclear hormone receptor 0.0071 0.1445 0.2608
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0071 0.1445 0.1424
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0336 0.0614
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0516 0.0516
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.0516 0.1513
Mycobacterium ulcerans peptide deformylase 0.0279 0.6545 1
Onchocerca volvulus 0.0026 0.0336 0.0959
Schistosoma mansoni ets-related 0.0217 0.5024 0.5012
Schistosoma mansoni cpg binding protein 0.009 0.1897 0.1877
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0062 0.1202 0.1202
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0836 0.149
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0836 0.1245
Schistosoma mansoni cpg binding protein 0.0085 0.1777 0.1758
Onchocerca volvulus Huntingtin homolog 0.0118 0.2598 0.7911
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.016 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0516 0.0943
Echinococcus multilocularis smad 0.0016 0.0081 0.0081
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0071 0.1445 0.1424
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0034 0.0516 0.0943
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.016 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0516 0.0943
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0081 0.0148
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0836 1
Schistosoma mansoni hypothetical protein 0.0062 0.1202 0.118
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0038 0.0616 0.0616
Schistosoma mansoni smad1 5 8 and 0.0016 0.0081 0.0057
Schistosoma mansoni hypothetical protein 0.0167 0.38 0.3785
Loa Loa (eye worm) hypothetical protein 0.0071 0.1445 0.2641
Echinococcus multilocularis lamin 0.0026 0.0336 0.0336
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0034 0.0516 0.0943
Schistosoma mansoni nuclear receptor 0.0034 0.0516 0.0493
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.016 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0034 0.0516 0.0516

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3 nM Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme ChEMBL. 14684298
IC50 (binding) = 3 nM Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme ChEMBL. 14684298
MIC (functional) = 12.5 uM Minimum inhibitory concentration required for primary screening against in-house strain of Escherichia coli tested in vitro ChEMBL. 14684298
MIC (functional) = 12.5 uM Minimum inhibitory concentration required for primary screening against in-house strain of Escherichia coli tested in vitro ChEMBL. 14684298
MIC (functional) = 50 uM Minimum inhibitory concentration required for primary screening against in-house strain of Staphylococcus capitis tested in vitro ChEMBL. 14684298

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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