Detailed information for compound 271473

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 546.652 | Formula: C29H42N2O8
  • H donors: 1 H acceptors: 2 LogP: 4.52 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCOc1cc(cc(c1OCCC)N(C(=O)N(O)C)CC)[C@H]1CC[C@@H](O1)c1cc(OC)c(c(c1)OC)OC
  • InChi: 1S/C29H42N2O8/c1-8-13-37-26-18-19(15-21(27(26)38-14-9-2)31(10-3)29(32)30(4)33)22-11-12-23(39-22)20-16-24(34-5)28(36-7)25(17-20)35-6/h15-18,22-23,33H,8-14H2,1-7H3/t22-,23-/m1/s1
  • InChiKey: UPHCJDBGBFEYAD-DHIUTWEWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens platelet-activating factor receptor Starlite/ChEMBL No references
Rattus norvegicus Arachidonate 5-lipoxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus g-protein coupled receptor platelet-activating factor receptor 342 aa 302 aa 22.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni glutaminase 0.0908 0.8224 0.8224
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0491 0.363
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0052
Toxoplasma gondii DNA topoisomerase family protein 0.0018 0.0064 0.0427
Schistosoma mansoni topbp1 0.0011 0.0008 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0491 0.363
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0052 0.0052
Echinococcus granulosus calcium release activated calcium channel 0.1102 1 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0121 0.0763
Echinococcus granulosus Ankyrin 0.0013 0.0027 0.0027
Brugia malayi hypothetical protein 0.0011 0.0008 0.0008
Mycobacterium ulcerans glutaminase 0.0908 0.8224 1
Echinococcus multilocularis RUN 0.0024 0.0121 0.0121
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0016 0.0052 0.0052
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0016 0.0052 0.0052
Loa Loa (eye worm) XPG I-region family protein 0.0018 0.0064 0.0064
Brugia malayi Protein kinase domain containing protein 0.0014 0.0029 0.0029
Loa Loa (eye worm) TOPoisomerase family member 0.0174 0.1499 0.1499
Echinococcus granulosus netrin receptor unc 5 0.0013 0.0024 0.0024
Leishmania major DNA topoisomerase III, putative 0.0018 0.0064 0.0271
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.0491 0.363
Echinococcus multilocularis netrin receptor unc 5 0.0013 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0074 0.058 0.058
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0018 0.0064 0.043
Schistosoma mansoni RAR-like nuclear receptor 0.0016 0.0052 0.0052
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.1109 0.1109
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0008
Onchocerca volvulus 0.0265 0.2333 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0087 0.0696 0.5095
Echinococcus multilocularis flap endonuclease GEN 1 0.0018 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0129 0.1082 0.1082
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0016 0.0052 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0016 0.0052 0.0052
Brugia malayi polk-prov protein 0.002 0.0086 0.0086
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0216 0.0216
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0064 0.0491 0.0491
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0174 0.1499 0.1499
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0008
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0137 0.0137
Entamoeba histolytica hypothetical protein 0.022 0.1915 0.2738
Leishmania major hypothetical protein, conserved 0.0018 0.0064 0.0275
Plasmodium falciparum flap endonuclease 1 0.0087 0.0696 0.4642
Loa Loa (eye worm) flap endonuclease-1 0.0087 0.0696 0.0696
Echinococcus granulosus bloom syndrome protein 0.0026 0.0137 0.0137
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0011 0.0008 0.0051
Entamoeba histolytica hypothetical protein 0.012 0.0998 0.1422
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0016 0.0052 0.0052
Loa Loa (eye worm) DNA topoisomerase III 0.0018 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0052
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0052 0.0052
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0086 0.0587
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0016 0.0052 0.0052
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0064 0.0491 0.3529
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0216 0.0216
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0018 0.0064 1
Treponema pallidum DNA topoisomerase I (topA) 0.0018 0.0064 0.134
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0052
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0157 0.1339 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0017 0.0017
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0105 0.0861 0.5743
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0064 0.0491 0.0491
Schistosoma mansoni hypothetical protein 0.0376 0.335 0.335
Plasmodium vivax DNA repair protein REV1, putative 0.002 0.0086 0.0523
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0137 0.0158
Leishmania major DNA topoisomerase III, putative 0.0018 0.0064 0.0271
Trypanosoma brucei DNA repair protein RAD2, putative 0.0018 0.0064 0.0427
Toxoplasma gondii DNA topoisomerase 2, putative 0.0174 0.1499 1
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0086 0.0587
Entamoeba histolytica exonuclease, putative 0.0018 0.0064 0.0082
Plasmodium vivax DNA topoisomerase II, putative 0.0174 0.1499 1
Entamoeba histolytica hypothetical protein 0.012 0.0998 0.1422
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.00000000004402 0.00000000029364
Brugia malayi steroid hormone receptor 0.0016 0.0052 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0491 0.363
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0064 0.0491 1
Brugia malayi DKFZp564C0469 protein 0.0011 0.0008 0.0008
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.012 0.0998 0.0998
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0016 0.0052 0.0052
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0137 0.1158 0.8645
Trichomonas vaginalis flap endonuclease-1, putative 0.0018 0.0064 0.0069
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.0491 0.363
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.1208 0.1208
Plasmodium falciparum DNA topoisomerase 2 0.0174 0.1499 1
Giardia lamblia DINP protein human, muc B family 0.0064 0.0491 0.0704
Echinococcus granulosus dna polymerase eta 0.0149 0.1266 0.1266
Entamoeba histolytica DNA topoisomerase III, putative 0.0018 0.0064 0.0081
Leishmania major DNA damage repair protein, putative 0.002 0.0086 0.0437
Brugia malayi hypothetical protein 0.0011 0.0008 0.0008
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0013 0.0024 0.0024
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0008
Schistosoma mansoni rab6-interacting 0.0024 0.0121 0.0121
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0491 0.0491
Plasmodium falciparum DNA topoisomerase 3, putative 0.0018 0.0064 0.0427
Trichomonas vaginalis exonuclease%2C+putative 0.0018 0.0064 0.0069
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0028 0.0158 0.0158
Onchocerca volvulus Bile acid receptor homolog 0.0016 0.0052 0.0191
Schistosoma mansoni hypothetical protein 0.012 0.0998 0.0998
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0018 0.0064 0.0064
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.0008 0.0051
Loa Loa (eye worm) RecQ helicase 0.0026 0.0137 0.0137
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0052 0.0052
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0057 0.0428 1
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0804 0.0804
Trypanosoma brucei DNA polymerase IV, putative 0.0064 0.0491 0.363
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0028 0.0157
Plasmodium falciparum replication factor C subunit 1, putative 0.0011 0.0008 0.0051
Echinococcus granulosus ecdysone induced protein 78C 0.0016 0.0052 0.0052
Giardia lamblia DNA repair protein RAD52 0.0772 0.6975 1
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0137 0.1158 0.8645
Giardia lamblia DNA topoisomerase II 0.0167 0.1429 0.2048
Mycobacterium tuberculosis Conserved hypothetical protein 0.0064 0.0491 1
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0018 0.0064 0.0069
Loa Loa (eye worm) steroid hormone receptor 0.0016 0.0052 0.0052
Brugia malayi hypothetical protein 0.0018 0.0068 0.0068
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.0893 0.0893
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0016 0.0052 0.0052
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.0893 0.0893
Trypanosoma brucei DNA topoisomerase III, putative 0.0018 0.0064 0.0424
Schistosoma mansoni hypothetical protein 0.0074 0.058 0.058
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0121 0.0121
Leishmania major DNA topoisomerase ii 0.0157 0.1339 1
Echinococcus granulosus flap endonuclease 1 0.0087 0.0696 0.0696
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.0893 0.0893
Brugia malayi Protein kinase domain containing protein 0.0098 0.0804 0.0804
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0491 0.363
Entamoeba histolytica DNA topoisomerase II, putative 0.0174 0.1499 0.2141
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0109 0.0727
Echinococcus multilocularis exonuclease 1 0.0018 0.0064 0.0064
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0064 0.0427
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0018 0.0064 0.0424
Entamoeba histolytica hypothetical protein 0.0098 0.0804 0.1144
Loa Loa (eye worm) hypothetical protein 0.0149 0.1266 0.1266
Entamoeba histolytica protein kinase, putative 0.0098 0.0804 0.1144
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0052 0.0052
Leishmania major hypothetical protein, conserved 0.0028 0.0158 0.0988
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0052 0.0052
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0018 0.0064 0.043
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0016 0.0052 0.0052
Echinococcus granulosus nuclear factor of activated T cells 5 0.0068 0.0523 0.0523
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0018 0.0064 0.0427
Leishmania major mitochondrial DNA topoisomerase II 0.0137 0.1158 0.8624
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0068 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0086 0.0587
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0018 0.0064 0.043
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0013 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0034 0.0216 0.0216
Leishmania major DNA polymerase kappa, putative 0.002 0.0086 0.0437
Trichomonas vaginalis DNA polymerase eta, putative 0.0064 0.0491 0.0588
Entamoeba histolytica protein kinase, putative 0.0098 0.0804 0.1144
Trypanosoma cruzi DNA topoisomerase III, putative 0.0018 0.0064 0.0424
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0216 0.0216
Echinococcus multilocularis GPCR, family 2 0.0034 0.0216 0.0216
Mycobacterium ulcerans DNA gyrase subunit B 0.0057 0.0428 0.0512
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0064 0.0427
Schistosoma mansoni coup transcription factor 0.0016 0.0052 0.0052
Schistosoma mansoni loxhd1 0.0024 0.0121 0.0121
Schistosoma mansoni hypothetical protein 0.0024 0.0121 0.0121
Trypanosoma brucei DNA polymerase IV, putative 0.0064 0.0491 0.363
Brugia malayi Uncoordinated protein 44 0.0013 0.0024 0.0024
Schistosoma mansoni exonuclease 0.0018 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0077 0.0609 0.0609
Onchocerca volvulus 0.0018 0.0064 0.0243
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family member 0.0018 0.0064 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0016 0.0052 0.0052
Echinococcus granulosus FTZ F1 alpha 0.0016 0.0052 0.0052
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0086 0.0587
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0008 0.0008
Schistosoma mansoni lipoxygenase 0.01 0.0815 0.0815
Loa Loa (eye worm) hypothetical protein 0.0037 0.0244 0.0244
Echinococcus granulosus death domain containing protein 0.0013 0.0024 0.0024
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0032 0.0194 0.4439
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0008
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0087 0.0696 0.5172
Giardia lamblia Exonuclease 1 0.0018 0.0064 0.0092
Brugia malayi hypothetical protein 0.0028 0.0158 0.0158
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0057 0.0428 1
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0018 0.0064 0.0064
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0086 0.0587
Schistosoma mansoni ankyrin 23/unc44 0.0013 0.0024 0.0024
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0057 0.0428 0.7898
Plasmodium falciparum DNA gyrase subunit B 0.0057 0.0428 0.2858
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0052 0.0052
Onchocerca volvulus 0.0024 0.0121 0.0489
Schistosoma mansoni DNA topoisomerase II 0.0174 0.1499 0.1499
Brugia malayi topoisomerase 0.0011 0.0008 0.0008
Brugia malayi Immunoglobulin I-set domain containing protein 0.0013 0.0024 0.0024
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0016 0.0052 0.0052
Mycobacterium ulcerans hypothetical protein 0.002 0.0086 0.0095
Trichomonas vaginalis flap endonuclease-1, putative 0.0018 0.0064 0.0069
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.058 0.058
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0016 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0034 0.0216 0.0216
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.006 0.0399
Schistosoma mansoni hypothetical protein 0.0012 0.0017 0.0017
Trypanosoma cruzi DNA polymerase eta, putative 0.0105 0.0861 0.6412
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0018 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.1102 1 1
Plasmodium vivax DNA gyrase subunit A, putative 0.0032 0.0194 0.1252
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0088 0.0088
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0137 0.0158
Echinococcus multilocularis Ankyrin 0.0013 0.0027 0.0027
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0018 0.0064 0.043
Echinococcus granulosus DNA repair protein complementing XP G cells 0.0018 0.0064 0.0064
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0772 0.6975 1
Mycobacterium ulcerans DNA polymerase IV 0.0064 0.0491 0.0588
Onchocerca volvulus 0.0016 0.0052 0.0191
Brugia malayi Steroid receptor seven-up type 2 0.0016 0.0052 0.0052
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0018 0.0064 0.0064
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0016 0.0052 0.0052
Giardia lamblia Replication factor C, subunit 1 0.0011 0.0008 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0016 0.0052 0.0052
Trypanosoma brucei unspecified product 0.0044 0.0308 0.226
Plasmodium vivax flap endonuclease 1, putative 0.0087 0.0696 0.4615
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0126 0.106 0.4527
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0064 0.0491 0.0588
Onchocerca volvulus Netrin receptor homolog 0.0013 0.0024 0.0072
Brugia malayi MH2 domain containing protein 0.0132 0.1109 0.1109
Echinococcus granulosus flap endonuclease GEN 1 0.0018 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.0013 0.0024 0.0024
Chlamydia trachomatis DNA gyrase subunit B 0.0057 0.0428 0.5524
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0491 0.363
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0052
Entamoeba histolytica DNA-repair protein, putative 0.0018 0.0064 0.0082
Chlamydia trachomatis DNA gyrase subunit B 0.0095 0.0769 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0158 0.1129
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0174 0.1499 0.1499
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0016 0.0052 0.0052
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0052 0.0052
Leishmania major DNA polymerase kappa, putative 0.0064 0.0491 0.3529
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0008 0.0008
Echinococcus multilocularis rho GTPase activating protein 20 0.0018 0.0064 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0016 0.0052 0.0052
Trypanosoma brucei unspecified product 0.0044 0.0308 0.226
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0308 0.226
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0216 0.0216
Plasmodium falciparum DNA gyrase subunit A 0.0032 0.0194 0.1297
Echinococcus granulosus dna polymerase kappa 0.0064 0.0491 0.0491
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0016 0.0052 0.0052
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0052 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0491 0.363
Loa Loa (eye worm) hypothetical protein 0.0108 0.0893 0.0893
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0057 0.0428 0.2858
Schistosoma mansoni rab6-interacting 0.0024 0.0121 0.0121
Echinococcus multilocularis calcium release activated calcium channel 0.1102 1 1
Schistosoma mansoni DNA polymerase eta 0.0149 0.1266 0.1266
Brugia malayi photoreceptor-specific nuclear receptor 0.0016 0.0052 0.0052
Brugia malayi hypothetical protein 0.0024 0.0121 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0016 0.0052 0.0052
Trypanosoma brucei DNA polymerase eta, putative 0.0149 0.1266 0.9456
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0016 0.0052 0.0191
Brugia malayi Probable DNA topoisomerase II 0.0174 0.1499 0.1499
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0491 0.363
Plasmodium falciparum DNA repair protein RAD2, putative 0.0018 0.0064 0.043
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0087 0.0696 0.5172
Mycobacterium ulcerans DNA topoisomerase I 0.0018 0.0064 0.0069
Loa Loa (eye worm) hypothetical protein 0.0078 0.0617 0.0617
Trypanosoma brucei chrX additional, unordered contigs 0.002 0.0086 0.0587
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0158 0.1053
Entamoeba histolytica exonuclease, putative 0.0018 0.0064 0.0082
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0052 0.0052
Echinococcus multilocularis dna polymerase kappa 0.0064 0.0491 0.0491
Plasmodium falciparum DNA repair protein REV1, putative 0.002 0.0086 0.0571
Schistosoma mansoni polycystin 1-related 0.0024 0.0121 0.0121
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.002 0.0086 0.0086
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.0491 0.363
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0016 0.0052 0.0052
Echinococcus granulosus RUN 0.0024 0.0121 0.0121
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0491 0.363
Echinococcus multilocularis nibrin 0.0011 0.0008 0.0008
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0032 0.0194 0.1297
Brugia malayi Flap endonuclease-1 0.0087 0.0696 0.0696
Trypanosoma brucei DNA topoisomerase III, putative 0.0018 0.0064 0.0424
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0032 0.0194 0.4439
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0086 0.0587
Echinococcus granulosus exonuclease 1 0.0018 0.0064 0.0064
Chlamydia trachomatis DNA topoisomerase I 0.0018 0.0064 0.074
Brugia malayi DNA topoisomerase III beta-1 0.0018 0.0064 0.0064
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0018 0.0064 0.134
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0008 0.0008
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0062 0.0363
Brugia malayi Doublecortin family protein 0.0024 0.0121 0.0121
Echinococcus granulosus dual specificity 0.0098 0.0804 0.0804
Leishmania major DNA polymerase eta, putative 0.0149 0.1266 0.9447
Trichomonas vaginalis glutaminase, putative 0.0908 0.8224 1
Plasmodium vivax DNA topoisomerase 3, putative 0.0018 0.0064 0.0378
Trypanosoma brucei DNA polymerase IV, putative 0.0064 0.0491 0.363
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0018 0.0064 0.0064
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0174 0.1499 0.1499
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0008
Schistosoma mansoni steroid hormone receptor ad4bp 0.0016 0.0052 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0086 0.0587
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0308 0.226
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0121 0.081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0016 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0034 0.0216 0.0216
Brugia malayi olfactory channel protein osm-9 0.0078 0.0617 0.0617
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0086 0.0587
Loa Loa (eye worm) hypothetical protein 0.0117 0.0974 0.0974
Entamoeba histolytica hypothetical protein 0.012 0.0998 0.1422
Trypanosoma cruzi DNA polymerase eta, putative 0.0149 0.1266 0.9456
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.0491 0.363
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0017 0.0017
Chlamydia trachomatis DNA gyrase subunit A 0.0032 0.0194 0.2452
Giardia lamblia DNA damage repair protein 0.002 0.0086 0.0123
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0137 0.0137
Onchocerca volvulus Protein ultraspiracle homolog 0.0016 0.0052 0.0191
Loa Loa (eye worm) hypothetical protein 0.0037 0.0244 0.0244
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.022 0.1915 0.2738
Schistosoma mansoni transcription factor LCR-F1 0.012 0.0998 0.0998
Entamoeba histolytica DNA topoisomerase III, putative 0.0018 0.0064 0.0081
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0098 0.0804 0.5923
Mycobacterium ulcerans DNA polymerase IV 0.0064 0.0491 0.0588
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0121 0.0121
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0018 0.0064 0.0064
Toxoplasma gondii ImpB/MucB/SamB family protein 0.002 0.0086 0.0571
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0086 0.0587
Loa Loa (eye worm) glutaminase 0.0908 0.8224 0.8224
Schistosoma mansoni hypothetical protein 0.0376 0.335 0.335
Entamoeba histolytica protein kinase domain containing protein 0.0098 0.0804 0.1144
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0098 0.0804 0.5986
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0008 0.0008
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0158 0.1053
Loa Loa (eye worm) hypothetical protein 0.0034 0.0216 0.0216
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0008 0.0008
Giardia lamblia Flap structure-specific endonuclease 0.0087 0.0696 0.0998
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0308 0.226
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0016 0.0052 0.0052
Leishmania major DNA polymerase eta, putative 0.0105 0.0861 0.6355
Echinococcus multilocularis DNA repair protein complementing XP G cells 0.0018 0.0064 0.0064
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0216 0.0216
Giardia lamblia hypothetical protein 0.0018 0.0064 0.0092
Brugia malayi hypothetical protein 0.0024 0.0121 0.0121
Trypanosoma cruzi DNA topoisomerase II, putative 0.0157 0.1339 1
Trypanosoma cruzi DNA topoisomerase III, putative 0.0018 0.0064 0.0424
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.002 0.0086 0.0571
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0216 0.0216
Schistosoma mansoni hypothetical protein 0.0034 0.0216 0.0216
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0064 0.0491 0.0491
Brugia malayi GRF zinc finger family protein 0.0018 0.0064 0.0064
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0028 0.003
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0064 0.0491 0.0491
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0052
Schistosoma mansoni retinoic acid receptor RXR 0.0016 0.0052 0.0052
Echinococcus multilocularis ecdysone induced protein 78C 0.0016 0.0052 0.0052
Brugia malayi Pax transcription factor protein 2 0.0265 0.2333 0.2333
Trichomonas vaginalis flap endonuclease-1, putative 0.0087 0.0696 0.0838
Echinococcus granulosus nibrin 0.0011 0.0008 0.0008
Trypanosoma cruzi DNA topoisomerase II, putative 0.0157 0.1339 1
Schistosoma mansoni DNA polymerase IV / kappa 0.002 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0064
Entamoeba histolytica hypothetical protein 0.012 0.0998 0.1422
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0064
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0158 0.1129
Brugia malayi Death domain containing protein 0.0013 0.0024 0.0024
Mycobacterium ulcerans DNA gyrase subunit A 0.0032 0.0194 0.0227
Loa Loa (eye worm) hypothetical protein 0.0117 0.0974 0.0974
Schistosoma mansoni Protein orai-1 0.1102 1 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.1208 0.1208
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0016 0.0052 0.0052
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family 0.0018 0.0064 0.0064
Loa Loa (eye worm) glutaminase 2 0.0908 0.8224 0.8224
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0016 0.0052 0.0052
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0028 0.0157
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0028 0.0025
Onchocerca volvulus 0.0024 0.0121 0.0489
Loa Loa (eye worm) hypothetical protein 0.0098 0.08 0.08
Trypanosoma cruzi DNA topoisomerase III, putative 0.0018 0.0064 0.0424
Schistosoma mansoni netrin receptor unc5 0.0013 0.0024 0.0024
Echinococcus multilocularis geminin 0.0376 0.335 0.335
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0037 0.0244 0.0244
Trypanosoma brucei exonuclease, putative 0.0018 0.0064 0.0427
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0121
Echinococcus granulosus GPCR family 2 0.0034 0.0216 0.0216
Echinococcus multilocularis FTZ F1 alpha 0.0016 0.0052 0.0052
Echinococcus multilocularis flap endonuclease 1 0.0087 0.0696 0.0696
Loa Loa (eye worm) pax transcription factor protein 2 0.0265 0.2333 0.2333
Loa Loa (eye worm) hypothetical protein 0.0077 0.0609 0.0609
Chlamydia trachomatis DNA gyrase subunit A 0.0032 0.0194 0.2452
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.1109 0.1109
Trypanosoma brucei DNA topoisomerase ii 0.0137 0.1158 0.8645
Trichomonas vaginalis flap endonuclease-1, putative 0.0018 0.0064 0.0069
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0016 0.0052 0.0052
Schistosoma mansoni terminal deoxycytidyl transferase 0.0064 0.0491 0.0491
Schistosoma mansoni topbp1 0.0011 0.0008 0.0008
Echinococcus granulosus geminin 0.0376 0.335 0.335
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0018 0.0064 0.0427
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0087 0.0696 0.4642
Echinococcus multilocularis dna polymerase eta 0.0149 0.1266 0.1266
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0086 0.0587
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0491 0.363
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0491 0.363
Entamoeba histolytica Flap nuclease, putative 0.0087 0.0696 0.0988
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0027
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0126 0.106 0.4527
Plasmodium vivax DNA gyrase subunit B, putative 0.0057 0.0428 0.2822
Plasmodium vivax DNA repair protein RAD2, putative 0.0018 0.0064 0.0381
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0018 0.0064 0.0427
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0016 0.0052 0.0052
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0098 0.08 0.08
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0024
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0158 0.1007
Brugia malayi XPG I-region family protein 0.0018 0.0064 0.0064
Echinococcus multilocularis thyroid hormone receptor alpha 0.0016 0.0052 0.0052
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0121 0.0121
Trypanosoma brucei DNA topoisomerase IA, putative 0.0018 0.0064 0.0424
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0098 0.0804 0.5986
Brugia malayi nuclear receptor NHR-88 0.0016 0.0052 0.0052
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0121 0.0121
Schistosoma mansoni lipoxygenase 0.0142 0.1208 0.1208
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0016 0.0052 0.0052
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0157 0.1339 1
Plasmodium falciparum exonuclease I, putative 0.0018 0.0064 0.043
Trichomonas vaginalis flap endonuclease-1, putative 0.0018 0.0064 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0052 0.0052
Plasmodium vivax exonuclease I, putative 0.0018 0.0064 0.0381
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0052
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0174 0.1499 0.1499
Schistosoma mansoni Protein orai-1 0.1102 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0158 0.1053
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0016 0.0052 0.0052
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0018 0.0064 0.0424
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0052
Leishmania major DNA topoisomerase 1A 0.0018 0.0064 0.0271
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0018 0.0064 0.0069
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0126 0.106 0.4527
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0098 0.0804 0.0804
Schistosoma mansoni flap endonuclease-1 0.0078 0.062 0.062
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0098 0.0804 0.5986
Trypanosoma brucei unspecified product 0.0064 0.0491 0.363
Entamoeba histolytica deoxycytidyl transferase, putative 0.0064 0.0491 0.0693
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0121
Brugia malayi hypothetical protein 0.012 0.0998 0.0998
Brugia malayi DNA topoisomerase III 0.0018 0.0064 0.0064
Brugia malayi ImpB/MucB/SamB family protein 0.0149 0.1266 0.1266
Giardia lamblia DNA topoisomerase III 0.0018 0.0064 0.0092
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0013 0.0027 0.0027
Trichomonas vaginalis DNA topoisomerase II, putative 0.0174 0.1499 0.1815
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0013 0.0024 0.0024
Brugia malayi glutaminase DH11.1 0.0908 0.8224 0.8224
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0052 0.0052
Brugia malayi ecdysteroid receptor 0.0016 0.0052 0.0052
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0158 0.1129
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0052 0.0052
Echinococcus multilocularis dual specificity 0.0098 0.0804 0.0804
Brugia malayi nuclear hormone receptor 0.0016 0.0052 0.0052
Giardia lamblia DNA topoisomerase III 0.0018 0.0064 0.0092
Schistosoma mansoni DNA ligase IV 0.0011 0.0008 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0016 0.0052 0.0052
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.012 0.0998 0.0998

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 68 nM In vitro affinity for human PAF receptor on platelet membranes using [3H]-PAF displacement. ChEMBL. No reference
IC50 (binding) = 68 nM In vitro affinity for human PAF receptor on platelet membranes using [3H]-PAF displacement. ChEMBL. No reference
IC50 (functional) = 3.07 uM In vitro inhibition of 5-lipoxygenase in RBL-2H3 (Rat basophilic leukaemia) cells. ChEMBL. No reference
IC50 (functional) = 3.07 uM In vitro inhibition of 5-lipoxygenase in RBL-2H3 (Rat basophilic leukaemia) cells. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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