Detailed information for compound 271898

Basic information

Technical information
  • TDR Targets ID: 271898
  • Name: 6-(4-fluorophenyl)-2-(octylamino)-4-oxo-1H-py rimidine-5-carbonitrile
  • MW: 342.411 | Formula: C19H23FN4O
  • H donors: 2 H acceptors: 4 LogP: 5.95 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCNc1nc(O)c(c(n1)c1ccc(cc1)F)C#N
  • InChi: 1S/C19H23FN4O/c1-2-3-4-5-6-7-12-22-19-23-17(16(13-21)18(25)24-19)14-8-10-15(20)11-9-14/h8-11H,2-7,12H2,1H3,(H2,22,23,24,25)
  • InChiKey: PKKHECMOCRWNFC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-(4-fluorophenyl)-4-keto-2-(octylamino)-1H-pyrimidine-5-carbonitrile
  • 4-(4-fluorophenyl)-2-(octylamino)-6-oxo-3H-pyrimidine-5-carbonitrile
  • 4-(4-fluorophenyl)-6-keto-2-(octylamino)-3H-pyrimidine-5-carbonitrile
  • 5-Pyrimidinecarbonitrile, 4-(4-fluorophenyl)-6-hydroxy-2-(octylamino)-
  • AIDS-170532
  • AIDS170532

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni phosphoglycerate kinase 0.0169 0.196 0.1953
Loa Loa (eye worm) hypothetical protein 0.0019 0.0045 0.0103
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0045 0.0103
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0293 0.0666
Plasmodium vivax amine transporter, putative 0.0031 0.0191 0.0934
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0169 0.196 0.4455
Loa Loa (eye worm) hypothetical protein 0.0019 0.0045 0.0103
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0335 0.1195
Echinococcus granulosus pyruvate kinase 0.0039 0.0294 0.0285
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0028 0.0163 0.079
Trypanosoma brucei phosphoglycerate kinase 0.0169 0.196 0.4455
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0202 0.2377 0.2371
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0045 0.0037
Plasmodium falciparum amino acid transporter, putative 0.0031 0.0191 0.0934
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0348 0.4247 0.9651
Onchocerca volvulus 0.003 0.018 0.064
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.0045 0.0036
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0456 0.1037
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0169 0.196 1
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0335 0.0762
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0166 0.0157
Echinococcus multilocularis sodium and chloride dependent glycine 0.0031 0.0191 0.0182
Schistosoma mansoni hypothetical protein 0.0018 0.0029 0.002
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0045 0.0036
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.0594 0.1349
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0108 0.0505
Echinococcus multilocularis microtubule associated protein 2 0.0799 1 1
Toxoplasma gondii exonuclease III APE 0.0019 0.0045 0.0187
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0335 0.1195
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0361 0.4401 1
Echinococcus multilocularis snurportin 1 0.0348 0.4247 0.4242
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0031 0.0191 0.0182
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0456 0.2293
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0281 0.0639
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0217 0.0494
Plasmodium falciparum phosphoglycerate kinase 0.0169 0.196 1
Schistosoma mansoni pyruvate kinase 0.0039 0.0294 0.0285
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.1322 0.673
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.018 0.0171
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0031 0.0191 0.0182
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0294 0.1048
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0009 0.002
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0029 0.0065
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0456 0.1037
Onchocerca volvulus 0.0236 0.2806 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.1169 0.5947
Schistosoma mansoni pyruvate kinase 0.0039 0.0294 0.0285
Trypanosoma brucei pyruvate kinase 1, putative 0.0039 0.0294 0.0668
Leishmania major hypothetical protein, conserved 0.0051 0.0456 0.1037
Loa Loa (eye worm) hypothetical protein 0.0202 0.2377 0.5402
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0031 0.0191 0.0182
Trypanosoma cruzi dynamin-1-like protein 0.0021 0.0068 0.0154
Toxoplasma gondii thioredoxin reductase 0.0047 0.0401 0.2009
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0031 0.0191 0.0434
Brugia malayi hypothetical protein 0.0031 0.0191 0.0434
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0045 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0045 0.0103
Brugia malayi nuclear hormone receptor 0.0019 0.0045 0.0103
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0281 0.0639
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0045 0.0103
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0062 0.0594 0.1349
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0191 0.0934
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.1322 0.673
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0045 0.0162
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0045 0.0036
Loa Loa (eye worm) solute carrier family 6 member 4 0.0031 0.0191 0.0434
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0045 0.0036
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0045 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0045 0.0103
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0009 0.0032
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0009 0.002
Schistosoma mansoni ran 0.0024 0.0108 0.0099
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0202 0.2377 0.2371
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0019 0.0045 0.0161
Giardia lamblia Pyruvate kinase 0.0039 0.0294 0.1461
Plasmodium vivax dynamin protein, putative 0.0021 0.0068 0.0303
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0335 0.1673
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0009 0.002
Onchocerca volvulus 0.0031 0.0191 0.0681
Toxoplasma gondii pyruvate kinase PyKII 0.002 0.0054 0.0231
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0294 0.1048
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0045 0.0187
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0045 0.0103
Mycobacterium ulcerans hypothetical protein 0.0028 0.0163 0.079
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0361 0.4401 1
Plasmodium vivax phosphoglycerate kinase, putative 0.0169 0.196 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0045 0.0103
Plasmodium falciparum pyruvate kinase 0.0039 0.0294 0.1461
Schistosoma mansoni sodium/chloride dependent transporter 0.0031 0.0191 0.0182
Loa Loa (eye worm) norepinephrine transporter 0.0031 0.0191 0.0434
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0095 0.0086
Echinococcus multilocularis pyruvate kinase 0.002 0.0054 0.0045
Leishmania major GTP-binding protein, putative 0.0021 0.0068 0.0154
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.2442 0.5548
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0217 0.1069
Entamoeba histolytica phosphoglycerate kinase, putative 0.0169 0.196 1
Echinococcus multilocularis GPCR, family 2 0.0018 0.0029 0.002
Leishmania major importin beta-1 subunit, putative 0.0026 0.0139 0.0315
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0045 0.0187
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0045 0.0103
Loa Loa (eye worm) hypothetical protein 0.0051 0.0456 0.1037
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0045 0.0103
Plasmodium vivax glutathione reductase, putative 0.0047 0.0401 0.2009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0045 0.0103
Onchocerca volvulus 0.0031 0.0191 0.0681
Echinococcus multilocularis pyruvate kinase 0.0039 0.0294 0.0285
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0401 0.2009
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0009 0.0032
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0281 0.0272
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0335 0.0327
Schistosoma mansoni dynamin 0.0023 0.0088 0.008
Leishmania major GTP-binding protein, putative 0.0024 0.0108 0.0244
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0335 0.0762
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0045 0.0036
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0062 0.0594 0.1349
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0009 0.002
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0045 0.0187
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0009 0.002
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0045 0.0036
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0045 0.0103
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0045 0.0187
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.018 0.0171
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0401 0.0392
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0031 0.0191 0.0434
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0029 0.002
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0031 0.0191 0.0934
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0108 0.0244
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0335 0.1195
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0028 0.0163 0.0581
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0401 0.0911
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0039 0.0294 0.1461
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.1169 0.5947
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.1322 0.673
Schistosoma mansoni inositol monophosphatase 0.0038 0.0281 0.0272
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0031 0.0191 0.0434
Brugia malayi Dynamin central region family protein 0.0021 0.0068 0.0154
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.018 0.0171
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0281 0.0639
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0045 0.0162
Schistosoma mansoni hypothetical protein 0.0348 0.4247 0.4242
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0335 0.1195
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0281 0.1395
Schistosoma mansoni hypothetical protein 0.0023 0.0095 0.0086
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0294 0.1048
Mycobacterium tuberculosis Conserved protein 0.0028 0.0163 0.079
Echinococcus granulosus pyruvate kinase 0.002 0.0054 0.0045
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0401 0.0392
Treponema pallidum sodium- and chloride- dependent transporter 0.0031 0.0191 0.0934
Schistosoma mansoni hypothetical protein 0.0018 0.0029 0.002
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0031 0.0191 0.0934
Echinococcus granulosus importin subunit beta 1 0.0033 0.0217 0.0209
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0045 0.0036
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0202 0.2377 0.2371
Brugia malayi Dynamin 0.0023 0.0088 0.0201
Toxoplasma gondii hypothetical protein 0.0031 0.0191 0.0934
Onchocerca volvulus 0.0031 0.0191 0.0681
Trichomonas vaginalis dynamin, putative 0.0021 0.0068 0.0242
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0045 0.0103
Loa Loa (eye worm) hypothetical protein 0.0019 0.0045 0.0103
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0031 0.0191 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0045 0.0103
Schistosoma mansoni alpha glucosidase 0.0042 0.0335 0.0327
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0031 0.0191 0.0182
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0294 0.0668
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0045 0.0187
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0281 0.1002
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0031 0.0191 0.0434
Loa Loa (eye worm) hypothetical protein 0.0019 0.0045 0.0103
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.018 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0045 0.0103
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0029 0.002
Echinococcus granulosus citrate lyase subunit beta protein 0.0028 0.0163 0.0154
Brugia malayi glutathione reductase 0.0047 0.0401 0.0911
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0031 0.0191 0.0182
Schistosoma mansoni microtubule-associated protein tau 0.0799 1 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.1169 0.5947
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0045 0.0103
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.018 0.0876
Schistosoma mansoni sodium/chloride dependent transporter 0.0031 0.0191 0.0182
Echinococcus multilocularis pyruvate kinase 0.0031 0.019 0.0181
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0294 0.0668
Trypanosoma brucei phosphoglycerate kinase, putative 0.0062 0.0594 0.1349
Toxoplasma gondii hypothetical protein 0.0031 0.0191 0.0934
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0045 0.0036
Trypanosoma brucei dynamin-1-like protein 0.0021 0.0068 0.0154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0045 0.0103
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0108 0.0244
Schistosoma mansoni dynamin 0.0021 0.0068 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0045 0.0103
Trypanosoma brucei C-8 sterol isomerase, putative 0.0361 0.4401 1
Trypanosoma brucei dynamin-1-like protein 0.0021 0.0068 0.0154
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0169 0.196 0.6985
Loa Loa (eye worm) hypothetical protein 0.0031 0.0191 0.0434
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0202 0.2377 0.2371
Mycobacterium ulcerans hypothetical protein 0.0028 0.0163 0.079
Plasmodium falciparum dynamin-like protein 0.0021 0.0068 0.0303
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0169 0.196 0.4455
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0045 0.0036
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0045 0.0036
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0028 0.0163 0.079
Entamoeba histolytica hypothetical protein 0.0026 0.0139 0.0708
Leishmania major phosphoglycerate kinase C, glycosomal 0.0169 0.196 0.4455
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0294 0.0668
Loa Loa (eye worm) pyruvate kinase-PB 0.0027 0.0145 0.0329
Brugia malayi Pre-SET motif family protein 0.003 0.018 0.0408
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0045 0.0103
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0029 0.0065
Loa Loa (eye worm) hypothetical protein 0.0361 0.4401 1
Brugia malayi Importin beta-1 subunit 0.0033 0.0217 0.0494
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0202 0.2377 0.2371
Echinococcus granulosus dynamin 1 protein 0.0021 0.0068 0.0059
Loa Loa (eye worm) hypothetical protein 0.0031 0.0191 0.0434
Onchocerca volvulus 0.0031 0.0191 0.0681
Echinococcus multilocularis pyruvate kinase 0.002 0.0054 0.0045
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0108 0.0505
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.018 0.0171
Echinococcus granulosus sodium and chloride dependent glycine 0.0031 0.0191 0.0182
Plasmodium falciparum importin beta, putative 0.0033 0.0217 0.1069
Plasmodium falciparum dynamin-like protein 0.0021 0.0068 0.0303
Schistosoma mansoni hypothetical protein 0.0364 0.4451 0.4446
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0108 0.0099
Mycobacterium leprae Probable pyruvate kinase PykA 0.0039 0.0294 0.0366
Echinococcus granulosus vesicular acetylcholine transporter 0.0216 0.2563 0.2556
Echinococcus granulosus phosphoglycerate kinase 1 0.0169 0.196 0.1953
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0031 0.0191 0.0434
Schistosoma mansoni vesicular acetylcholine transporter 0.0216 0.2563 0.2556
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0108 0.0505
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0139 0.0494
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0045 0.0103
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0045 0.0036
Loa Loa (eye worm) hypothetical protein 0.0031 0.0191 0.0434
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0045 0.0103
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.018 0.0171
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.0056 0.0521 0.1184
Echinococcus granulosus lysosomal alpha glucosidase 0.0189 0.2209 0.2202
Trichomonas vaginalis set domain proteins, putative 0.0236 0.2806 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0009 0.002
Onchocerca volvulus Bile acid receptor homolog 0.0019 0.0045 0.0161
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0456 0.2293
Echinococcus multilocularis dynamin 1 0.0023 0.0088 0.008
Brugia malayi steroid hormone receptor 0.0019 0.0045 0.0103
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0456 0.1037
Schistosoma mansoni hypothetical protein 0.0018 0.0029 0.002
Leishmania major C-8 sterol isomerase-like protein 0.0361 0.4401 1
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0139 0.0494
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0169 0.196 1
Trichomonas vaginalis mgm1, putative 0.0021 0.0068 0.0242
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0401 0.0911
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0045 0.0037
Loa Loa (eye worm) hypothetical protein 0.0019 0.0045 0.0103
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0045 0.0036
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0216 0.2563 0.5823
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0281 0.0639
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0045 0.0103
Entamoeba histolytica dynamin-like protein 0.0021 0.0068 0.0347
Loa Loa (eye worm) hypothetical protein 0.0184 0.2152 0.489
Echinococcus multilocularis vesicular acetylcholine transporter 0.0216 0.2563 0.2556
Echinococcus multilocularis pyruvate kinase 0.0039 0.0294 0.0285
Plasmodium falciparum transporter, putative 0.0031 0.0191 0.0934
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0169 0.196 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0108 0.0099
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0281 0.1395
Schistosoma mansoni ran 0.0024 0.0108 0.0099
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0281 0.1002
Loa Loa (eye worm) hypothetical protein 0.0031 0.0191 0.0434
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0031 0.0191 0.0182
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0045 0.0036
Schistosoma mansoni phosphoglycerate kinase 0.0169 0.196 0.1953
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0009 0.002
Schistosoma mansoni hypothetical protein 0.0364 0.4451 0.4446
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0045 0.0036
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.018 0.0171
Loa Loa (eye worm) serotonin transporter b 0.0031 0.0191 0.0434
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0108 0.0244
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0335 0.171
Loa Loa (eye worm) hypothetical protein 0.0031 0.0191 0.0434
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0108 0.0244
Giardia lamblia Pyruvate kinase 0.002 0.0054 0.0231
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0009 0.002
Brugia malayi RNA, U transporter 1 0.0093 0.0985 0.2239
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0065
Echinococcus granulosus sodium and chloride dependent glycine 0.0031 0.0191 0.0182
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0335 0.0762
Giardia lamblia Dynamin 0.0021 0.0068 0.0303
Plasmodium falciparum pyruvate kinase 2 0.002 0.0054 0.0231
Onchocerca volvulus Protein ultraspiracle homolog 0.0019 0.0045 0.0161
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0045 0.0036
Echinococcus granulosus geminin 0.0364 0.4451 0.4446
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0009 0.002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0029 0.002
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0031 0.0191 0.0182
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0045 0.0103
Schistosoma mansoni ap endonuclease 0.0019 0.0045 0.0037
Mycobacterium ulcerans pyruvate kinase 0.0039 0.0294 0.1461
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0045 0.0103
Schistosoma mansoni sodium/chloride dependent transporter 0.0031 0.0191 0.0182
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0031 0.0191 0.0434
Echinococcus granulosus dynamin 0.0021 0.0068 0.0059
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.1169 0.5947
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0045 0.0103
Echinococcus granulosus pyruvate kinase 0.002 0.0054 0.0045
Trichomonas vaginalis dynamin, putative 0.0021 0.0068 0.0242
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0294 0.1048
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0028 0.0163 0.0371
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0028 0.0163 0.0371
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.1322 0.631
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0031 0.0191 0.0934
Schistosoma mansoni sodium-dependent amino acid transporter 0.0031 0.0191 0.0182
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0521 0.1184
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0139 0.0315
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0108 0.0244
Brugia malayi Pyruvate kinase, muscle isozyme 0.0039 0.0294 0.0668
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.1169 0.5947
Leishmania major trypanothione reductase 0.0047 0.0401 0.0911
Echinococcus granulosus pyruvate kinase 0.002 0.0054 0.0045
Trichomonas vaginalis ran, putative 0.0024 0.0108 0.0383
Brugia malayi Phosphoglycerate kinase 0.0169 0.196 0.4455
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0401 0.2009
Plasmodium vivax pyruvate kinase, putative 0.0039 0.0294 0.1461
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0031 0.0191 0.0182
Giardia lamblia Phosphoglycerate kinase 0.0169 0.196 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0108 0.0505
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0456 0.2293
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0045 0.0103
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0521 0.1184
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0045 0.0036
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0169 0.196 0.6985
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0045 0.0232
Brugia malayi Pre-SET motif family protein 0.0207 0.2442 0.5548
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0521 0.1184
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0045 0.0036
Chlamydia trachomatis pyruvate kinase 0.0039 0.0294 0.1461
Loa Loa (eye worm) hypothetical protein 0.0039 0.0294 0.0668
Brugia malayi Thioredoxin reductase 0.0047 0.0401 0.0911
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0045 0.0036
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0028 0.0163 0.079
Loa Loa (eye worm) hypothetical protein 0.0031 0.0191 0.0434
Trichomonas vaginalis dynamin, putative 0.0021 0.0068 0.0242
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0169 0.196 1
Plasmodium falciparum thioredoxin reductase 0.0047 0.0401 0.2009
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0045 0.0187
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0031 0.0191 0.0934
Plasmodium falciparum glutathione reductase 0.0047 0.0401 0.2009
Brugia malayi Inositol-1 0.0038 0.0281 0.0639
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0062 0.0594 0.1349
Leishmania major phosphoglycerate kinase B, cytosolic 0.0169 0.196 0.4455
Loa Loa (eye worm) hypothetical protein 0.003 0.018 0.0408
Leishmania major hypothetical protein, conserved 0.0246 0.2945 0.6692
Schistosoma mansoni alpha-glucosidase 0.0162 0.1874 0.1866
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0281 0.1434
Trypanosoma brucei trypanothione reductase 0.0047 0.0401 0.0911
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0294 0.0668
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0045 0.0103
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0031 0.0191 0.0434
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0335 0.1195
Entamoeba histolytica dynamin-1-like protein, putative 0.0021 0.0068 0.0347
Brugia malayi Pyruvate kinase, M2 isozyme 0.0039 0.0294 0.0668
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.1169 0.5427
Entamoeba histolytica Ran family GTPase 0.0024 0.0108 0.0548
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0045 0.0187
Loa Loa (eye worm) hypothetical protein 0.0031 0.0191 0.0434
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0045 0.0103
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0335 0.0327
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0095 0.0086
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0009 0.002
Schistosoma mansoni alpha-glucosidase 0.0162 0.1874 0.1866
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0217 0.0209
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.0594 0.1349
Trichomonas vaginalis interferon-induced GTP-binding protein mx, putative 0.0021 0.0068 0.0242
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.0169 0.196 0.4455
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0029 0.0065
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0294 0.0668
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0009 0.002
Brugia malayi hypothetical protein 0.0051 0.0456 0.1037
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0189 0.2209 0.502
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0045 0.0036
Echinococcus granulosus snurportin 1 0.0348 0.4247 0.4242
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0335 0.0762
Loa Loa (eye worm) hypothetical protein 0.0023 0.0088 0.0201
Brugia malayi vesicular acetylcholine transporter unc-17 0.0216 0.2563 0.5823
Loa Loa (eye worm) hypothetical protein 0.0033 0.0217 0.0494
Onchocerca volvulus 0.0019 0.0045 0.0161
Brugia malayi hypothetical protein 0.0033 0.0224 0.0509
Plasmodium vivax importin-beta 2, putative 0.0033 0.0217 0.1069
Echinococcus granulosus GPCR family 2 0.0018 0.0029 0.002
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0045 0.0103
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0031 0.0191 0.0182
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0335 0.1195
Trypanosoma brucei hypothetical protein, conserved 0.0246 0.2945 0.6692
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0009 0.002
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0281 0.0272
Onchocerca volvulus 0.0109 0.1194 0.4254
Toxoplasma gondii pyruvate kinase PyK1 0.0039 0.0294 0.1461
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0045 0.0036
Schistosoma mansoni importin beta-1 0.0033 0.0217 0.0209
Toxoplasma gondii dynamin-related protein DRPA 0.0021 0.0068 0.0303
Loa Loa (eye worm) hypothetical protein 0.0202 0.2377 0.5402
Brugia malayi Phosphoglycerate kinase 0.0062 0.0594 0.1349
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0045 0.0103
Loa Loa (eye worm) DRP-1 protein 0.0021 0.0068 0.0154
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0045 0.0036
Mycobacterium ulcerans phosphoglycerate kinase 0.0169 0.196 1
Echinococcus multilocularis serotonin transporter 0.0031 0.0191 0.0182
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0335 0.1195
Trichomonas vaginalis dynamin, putative 0.0021 0.0068 0.0242
Trypanosoma brucei pyruvate kinase 1 0.0039 0.0294 0.0668
Entamoeba histolytica pyruvate kinase, putative 0.0027 0.0145 0.0739
Brugia malayi ecdysteroid receptor 0.0019 0.0045 0.0103
Echinococcus multilocularis dynamin 1 protein 0.0021 0.0068 0.0059
Loa Loa (eye worm) glutathione reductase 0.0047 0.0401 0.0911
Brugia malayi nuclear receptor NHR-88 0.0019 0.0045 0.0103
Echinococcus granulosus dynamin 1 0.0023 0.0088 0.008
Schistosoma mansoni coup transcription factor 0.0019 0.0045 0.0036
Echinococcus multilocularis lysosomal alpha glucosidase 0.0189 0.2209 0.2202
Chlamydia trachomatis phosphoglycerate kinase 0.0169 0.196 1
Leishmania major pyruvate kinase 0.0039 0.0294 0.0668
Trichomonas vaginalis dynamin, putative 0.0021 0.0068 0.0242
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0031 0.0191 0.0182
Echinococcus multilocularis geminin 0.0364 0.4451 0.4446
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0216 0.2563 0.9132
Echinococcus multilocularis pyruvate kinase 0.002 0.0054 0.0045
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0045 0.0036
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0029 0.002
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0281 0.1395
Trypanosoma brucei phosphoglycerate kinase 0.0062 0.0594 0.1349
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0169 0.196 1
Schistosoma mansoni hypothetical protein 0.0018 0.0029 0.002
Trypanosoma brucei glucosidase, putative 0.0042 0.0335 0.0762
Echinococcus granulosus serotonin transporter 0.0031 0.0191 0.0182
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0045 0.0103
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0335 0.1195
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0009 0.002
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0335 0.1195
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0045 0.0036
Treponema pallidum phosphoglycerate kinase 0.0169 0.196 1
Echinococcus granulosus pyruvate kinase 0.0039 0.0294 0.0285
Schistosoma mansoni ap endonuclease 0.0019 0.0045 0.0037
Schistosoma mansoni inositol monophosphatase 0.0038 0.0281 0.0272
Echinococcus multilocularis dynamin 0.0021 0.0068 0.0059
Schistosoma mansoni hypothetical protein 0.0039 0.0293 0.0285
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0217 0.0494
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0045 0.0036
Loa Loa (eye worm) hypothetical protein 0.0027 0.0145 0.0329
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0045 0.0103
Schistosoma mansoni dynamin 0.0023 0.0088 0.008
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0028 0.0163 0.079
Mycobacterium tuberculosis Probable reductase 0.0107 0.1169 0.5947
Brugia malayi Dynamin 0.0023 0.0088 0.0201
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0294 0.1048
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0028 0.0163 0.0371
Plasmodium vivax dynamin-like protein, putative 0.0021 0.0068 0.0303
Toxoplasma gondii dynamin-related protein DRPB 0.0021 0.0068 0.0303
Echinococcus multilocularis phosphoglycerate kinase 1 0.0169 0.196 0.1953
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0456 0.2293
Plasmodium vivax SET domain protein, putative 0.003 0.018 0.0876
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0009 0.002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0045 0.0036
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.0594 0.1349
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0231 0.1137
Trypanosoma cruzi hypothetical protein, conserved 0.0246 0.2945 0.6692
Trypanosoma cruzi hypothetical protein, conserved 0.0246 0.2945 0.6692
Echinococcus multilocularis sodium and chloride dependent glycine 0.0031 0.0191 0.0182
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0009 0.002
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0335 0.0762
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0139 0.0494
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0281 0.1002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0045 0.0103
Loa Loa (eye worm) hypothetical protein 0.0019 0.0045 0.0103
Schistosoma mansoni pyruvate kinase 0.002 0.0054 0.0045
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0045 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0045 0.0103
Loa Loa (eye worm) hypothetical protein 0.0039 0.0293 0.0666
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.0045 0.0036
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0335 0.171
Brugia malayi Glycosyl hydrolases family 31 protein 0.0189 0.2209 0.502
Trypanosoma brucei phosphoglycerate kinase 0.0169 0.196 0.4455
Echinococcus multilocularis citrate lyase subunit beta protein 0.0028 0.0163 0.0154
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0045 0.0036
Trichomonas vaginalis dynamin, putative 0.0021 0.0068 0.0242
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0009 0.002
Leishmania major pyruvate kinase 0.0039 0.0294 0.0668
Plasmodium vivax pyruvate kinase 2, putative 0.002 0.0054 0.0231
Loa Loa (eye worm) hypothetical protein 0.0031 0.0191 0.0434
Loa Loa (eye worm) inositol-1 0.0038 0.0281 0.0639
Echinococcus multilocularis lysosomal alpha glucosidase 0.0189 0.2209 0.2202

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 In vitro inhibitory activity against Mycobacterium tuberculosis H37Ra cell viability (MABA) at a concentration of 50 and 25 mg/uL; NA means Inactive ChEMBL. 11844696

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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