Detailed information for compound 274088

Basic information

Technical information
  • TDR Targets ID: 274088
  • Name: pyridin-3-ylmethyl N-[(2S)-1-[[(3S)-1-tert-bu tylsulfanyl-2-oxo-5-phenylpentan-3-yl]amino]- 4-methyl-1-oxopentan-2-yl]carbamate
  • MW: 513.692 | Formula: C28H39N3O4S
  • H donors: 2 H acceptors: 4 LogP: 5.2 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(C[C@@H](C(=O)N[C@H](C(=O)CSC(C)(C)C)CCc1ccccc1)NC(=O)OCc1cccnc1)C
  • InChi: 1S/C28H39N3O4S/c1-20(2)16-24(31-27(34)35-18-22-12-9-15-29-17-22)26(33)30-23(25(32)19-36-28(3,4)5)14-13-21-10-7-6-8-11-21/h6-12,15,17,20,23-24H,13-14,16,18-19H2,1-5H3,(H,30,33)(H,31,34)/t23-,24-/m0/s1
  • InChiKey: WUKLOIZMYLWBNL-ZEQRLZLVSA-N  


Substructure search Similarity search

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Synonyms

  • 3-pyridylmethyl N-[(1S)-1-[[(1S)-3-tert-butylsulfanyl-2-oxo-1-phenethyl-propyl]carbamoyl]-3-methyl-butyl]carbamate
  • N-[(1S)-1-[[[(1S)-3-(tert-butylthio)-2-oxo-1-phenethylpropyl]amino]-oxomethyl]-3-methylbutyl]carbamic acid 3-pyridylmethyl ester
  • pyridin-3-ylmethyl N-[(2S)-1-[[(3S)-1-tert-butylsulfanyl-2-oxo-5-phenyl-pentan-3-yl]amino]-4-methyl-1-oxo-pentan-2-yl]carbamate
  • N-[(1S)-1-[[(1S)-3-(tert-butylthio)-2-keto-1-phenethyl-propyl]carbamoyl]-3-methyl-butyl]carbamic acid 3-pyridylmethyl ester
  • 3-pyridylmethyl N-[(1S)-1-[[(1S)-3-tert-butylsulfanyl-2-oxo-1-(2-phenylethyl)propyl]carbamoyl]-3-methyl-butyl]carbamate
  • N-[(1S)-1-[[[(1S)-3-(tert-butylthio)-2-oxo-1-(2-phenylethyl)propyl]amino]-oxomethyl]-3-methylbutyl]carbamic acid 3-pyridylmethyl ester
  • N-[(1S)-1-[[(1S)-3-(tert-butylthio)-2-keto-1-(2-phenylethyl)propyl]carbamoyl]-3-methyl-butyl]carbamic acid 3-pyridylmethyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine peptidase, putative 0.0029 0.0266 0.0861
Loa Loa (eye worm) hypothetical protein 0.0028 0.0235 0.0761
Brugia malayi Cathepsin L-like precursor 0.0052 0.071 0.23
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.071 0.1584
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0037 0.0419 0.033
Echinococcus multilocularis beta LACTamase domain containing family member 0.0028 0.0235 0.0144
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0023 0.0143 0.0052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.1813 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.071 0.1584
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0093 0.151 0.4893
Loa Loa (eye worm) cysteine protease 0.0052 0.071 0.23
Brugia malayi Probable ClpP-like protease 0.0119 0.2008 0.6508
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0063 0.0929 0.0929
Loa Loa (eye worm) cathepsin B 0.0063 0.0929 0.301
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.1813 1
Onchocerca volvulus 0.0052 0.071 0.1968
Echinococcus granulosus cathepsin b 0.0175 0.3086 0.3022
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0119 0.2008 0.1935
Onchocerca volvulus 0.0052 0.071 0.1968
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.0266 0.0861
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0419 0.0419
Brugia malayi Cathepsin L-like cysteine proteinase 0.0037 0.0407 0.1319
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0266 0.0103
Plasmodium vivax ataxin-2 like protein, putative 0.0019 0.0073 0.0366
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0037 0.0419 0.033
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0028 0.0235 0.0235
Loa Loa (eye worm) ctsf protein 0.0052 0.071 0.23
Echinococcus multilocularis cathepsin b 0.0175 0.3086 0.3022
Plasmodium vivax vivapain-1 0.0029 0.0266 0.1323
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.1813 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0235 0.0761
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0023 0.0143 0.0052
Loa Loa (eye worm) beta-lactamase 0.0028 0.0235 0.0761
Onchocerca volvulus Cathepsin L homolog 0.0052 0.071 0.1968
Trypanosoma cruzi cysteine peptidase, putative 0.0109 0.1813 0.5875
Trypanosoma cruzi cysteine peptidase, putative 0.0109 0.1813 0.5875
Trypanosoma cruzi cysteine proteinase, putative 0.0029 0.0266 0.0861
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.1813 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0407 0.1319
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.071 1
Leishmania major cathepsin L-like protease 0.0109 0.1813 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.071 0.1584
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0063 0.0929 0.4917
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0028 0.0235 0.0761
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0235 0.0927
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0063 0.0929 0.2314
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.071 0.1584
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.071 0.0624
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.071 0.071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.071 0.1584
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.071 0.1584
Brugia malayi beta-lactamase 0.0028 0.0235 0.0761
Loa Loa (eye worm) hypothetical protein 0.002 0.0092 0.0297
Brugia malayi Intermediate filament tail domain containing protein 0.002 0.0092 0.0297
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.071 0.1584
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0119 0.2008 1
Echinococcus multilocularis cysteine protease 0.0052 0.071 0.0624
Loa Loa (eye worm) hypothetical protein 0.002 0.0084 0.0273
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0023 0.0143 0.0143
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0119 0.2008 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.071 0.1584
Giardia lamblia Cathepsin B precursor 0.0063 0.0929 0.5
Brugia malayi hypothetical protein 0.0019 0.0073 0.0238
Loa Loa (eye worm) hypothetical protein 0.0028 0.0235 0.0761
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0029 0.0266 0.0266
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0119 0.2008 0.5
Brugia malayi beta-lactamase family protein 0.0028 0.0235 0.0761
Echinococcus granulosus beta LACTamase domain containing family member 0.0028 0.0235 0.0144
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0119 0.2008 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0407 0.1319
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0119 0.2008 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0037 0.0419 0.1357
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0407 0.3182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.071 0.1584
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0023 0.0143 0.0143
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.071 0.1584
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.071 0.1584
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.1813 1
Loa Loa (eye worm) hypothetical protein 0.0175 0.3086 1
Loa Loa (eye worm) fibroinase 0.0052 0.071 0.23
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0052 0.071 0.3289
Onchocerca volvulus 0.0052 0.071 0.1968
Plasmodium falciparum cysteine proteinase falcipain 3 0.0052 0.071 0.3289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0407 0.0574
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0029 0.0266 0.1105
Plasmodium vivax unspecified product 0.0029 0.0266 0.1323
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0078 0.1212 0.5511
Echinococcus granulosus cathepsin L cysteine protease 0.0029 0.0266 0.0176
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.071 0.071
Echinococcus granulosus cathepsin L cysteine proteinase 0.0052 0.071 0.0624
Leishmania major cathepsin L-like protease 0.0109 0.1813 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.071 0.1584
Trypanosoma cruzi PAB1-binding protein , putative 0.0019 0.0073 0.0238
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0175 0.3086 0.3086
Leishmania major cathepsin L-like protease 0.0052 0.071 0.3658
Brugia malayi Cathepsin L-like precursor 0.0037 0.0407 0.1319
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0119 0.2008 1
Brugia malayi Cathepsin L-like precursor 0.0052 0.071 0.23
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0119 0.2008 0.5
Leishmania major cathepsin L-like protease 0.0052 0.071 0.3658
Onchocerca volvulus 0.0052 0.071 0.1968
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.1813 1
Echinococcus multilocularis cysteine protease 0.0052 0.071 0.0624
Trypanosoma cruzi cysteine proteinase, putative 0.0029 0.0266 0.0861
Plasmodium vivax vivapain-2 0.0052 0.071 0.3534
Schistosoma mansoni hypothetical protein 0.0265 0.4849 0.4849
Plasmodium vivax vivapain-2 0.0052 0.071 0.3534
Schistosoma mansoni hypothetical protein 0.0265 0.4849 0.4849
Schistosoma mansoni peptidase Clp (S14 family) 0.0119 0.2008 0.2008
Leishmania major hypothetical protein, conserved 0.0028 0.0235 0.0927
Schistosoma mansoni microtubule-associated protein tau 0.0531 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0143 0.0463
Loa Loa (eye worm) hypothetical protein 0.0028 0.0235 0.0761
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0052 0.071 0.3289
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0029 0.0266 0.0266
Echinococcus multilocularis microtubule associated protein 2 0.0531 1 1
Onchocerca volvulus 0.0052 0.071 0.1968
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.071 0.0624
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0235 0.0761
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0419 0.0419
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.071 0.1584
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0029 0.0266 0.0266
Brugia malayi intermediate filament protein 0.002 0.0092 0.0297
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0175 0.3086 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0235 0.0761
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0052 0.071 0.23
Toxoplasma gondii cathepsin B 0.0063 0.0929 0.442
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0028 0.0235 0.0761
Onchocerca volvulus 0.0052 0.071 0.1968
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.071 0.1584
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0078 0.1212 0.3374
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.071 1
Echinococcus granulosus cathepsin l1 0.0037 0.0407 0.0318
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0022 0.0126 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.1813 1
Leishmania major cathepsin L-like protease 0.0052 0.071 0.3658
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0177 0.3131 1
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0041 0.0493 0.1459
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0119 0.2008 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0119 0.2008 1
Toxoplasma gondii hypothetical protein 0.0041 0.0493 0.217
Brugia malayi beta-lactamase family protein 0.0028 0.0235 0.0761
Onchocerca volvulus 0.0028 0.0235 0.0456
Echinococcus granulosus cathepsin b 0.0175 0.3086 0.3022
Brugia malayi cathepsin L-like precursor 0.0037 0.0407 0.1319
Loa Loa (eye worm) hypothetical protein 0.0119 0.2008 0.6508
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.071 0.23
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0078 0.1212 0.3374
Trypanosoma cruzi cruzipain precursor, putative 0.0109 0.1813 0.5875
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.1813 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.071 0.1584
Onchocerca volvulus 0.0037 0.0407 0.1004
Onchocerca volvulus Cathepsin L homolog 0.0052 0.071 0.1968
Echinococcus multilocularis cathepsin b 0.0175 0.3086 0.3022
Trypanosoma cruzi PAB1-binding protein , putative 0.0019 0.0073 0.0238
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0119 0.2008 0.1935
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.071 0.1584
Echinococcus granulosus cathepsin l1 0.0052 0.071 0.0624
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.071 0.1584
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.071 0.1584
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0023 0.0143 0.0358
Brugia malayi Cathepsin L-like precursor 0.0052 0.071 0.23
Toxoplasma gondii ABC1 family protein 0.0028 0.0235 0.0833
Onchocerca volvulus Cathepsin F homolog 0.0052 0.071 0.1968
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.071 0.1584
Leishmania major cysteine peptidase A (CPA) 0.0052 0.071 0.3658
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0175 0.3086 0.3086
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.071 0.23
Echinococcus multilocularis cathepsin L 0.0029 0.0266 0.0176
Schistosoma mansoni lamin 0.002 0.0092 0.0092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0023 0.0143 0.0143
Giardia lamblia Cathepsin B precursor 0.0063 0.0929 0.5
Echinococcus granulosus histone lysine methyltransferase setb 0.0023 0.0143 0.0052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0029 0.0266 0.1105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.071 0.1584
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.016 0.2804 0.9087
Onchocerca volvulus 0.0052 0.071 0.1968
Loa Loa (eye worm) hypothetical protein 0.0028 0.0235 0.0761
Plasmodium vivax vivapain-3 0.0029 0.0266 0.1323
Echinococcus granulosus cysteine protease 0.0029 0.0266 0.0176
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0419 0.0419
Echinococcus granulosus cathepsin l cysteine peptidase 0.0052 0.071 0.0624
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0175 0.3086 0.3086
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0029 0.0266 0.0861
Loa Loa (eye worm) hypothetical protein 0.0037 0.0407 0.1319
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.071 0.0624
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.0266 0.0861
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.0407 0.0407
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0041 0.0493 0.2457
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.1813 1
Echinococcus multilocularis geminin 0.0265 0.4849 0.4801
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.071 0.1584
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.071 0.1584
Leishmania major cathepsin L-like protease 0.0109 0.1813 1
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0235 0.1169
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0028 0.0235 0.0235
Entamoeba histolytica cysteine protease, putative 0.0052 0.071 1
Brugia malayi Cathepsin L-like precursor 0.0052 0.071 0.23
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0119 0.2008 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0266 0.0103
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0037 0.0419 0.1357
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0235 0.0761
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.1813 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.071 0.1584
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.002 0.0092 0.0297
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.1813 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0063 0.0929 0.301
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0175 0.3086 0.3086
Onchocerca volvulus 0.0028 0.0235 0.0456
Brugia malayi Pre-SET motif family protein 0.0023 0.0143 0.0463
Trypanosoma cruzi cysteine peptidase, putative 0.0109 0.1813 0.5875
Toxoplasma gondii cathepsin CPL 0.0052 0.071 0.3289
Plasmodium falciparum cysteine proteinase falcipain 1 0.0029 0.0266 0.0993
Leishmania major cathepsin L-like protease 0.0052 0.071 0.3658
Trypanosoma brucei cysteine peptidase C (CPC) 0.0063 0.0929 0.4917
Loa Loa (eye worm) intermediate filament protein 0.002 0.0092 0.0297
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.071 0.1584
Onchocerca volvulus 0.0028 0.0235 0.0456
Giardia lamblia Cathepsin B precursor 0.0063 0.0929 0.5
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.071 0.23
Trypanosoma cruzi cysteine protease, putative 0.0029 0.0266 0.0861
Brugia malayi cathepsin B-like cysteine proteinase 0.0175 0.3086 1
Plasmodium vivax SET domain protein, putative 0.0023 0.0143 0.0711
Loa Loa (eye worm) hypothetical protein 0.0052 0.071 0.23
Echinococcus granulosus cathepsin L 0.0029 0.0266 0.0176
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0407 0.0574
Schistosoma mansoni lamin 0.002 0.0092 0.0092
Brugia malayi Cathepsin L-like precursor 0.0037 0.0407 0.1319
Echinococcus granulosus peptidase Clp S14 family 0.0078 0.1212 0.1131
Schistosoma mansoni intermediate filament proteins 0.002 0.0092 0.0092
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0037 0.0419 0.033
Echinococcus granulosus geminin 0.0265 0.4849 0.4801
Onchocerca volvulus 0.0182 0.3234 1
Brugia malayi Cathepsin L-like precursor 0.0052 0.071 0.23
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.071 0.1584
Onchocerca volvulus 0.0023 0.0143 0.0163
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0037 0.0419 0.033
Trichomonas vaginalis set domain proteins, putative 0.0182 0.3234 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0078 0.1212 0.1131
Brugia malayi Cathepsin L-like precursor 0.0052 0.071 0.23
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0041 0.0493 0.217
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0238
Leishmania major cathepsin L-like protease 0.0052 0.071 0.3658
Trypanosoma cruzi major cysteine proteinase, putative 0.007 0.1066 0.3454
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0119 0.2008 1
Brugia malayi Pre-SET motif family protein 0.016 0.2804 0.9087
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0023 0.0143 0.0143
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.071 0.0624

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 2 nM Inhibitory activity against cruzain, the major cysteine protease found in T. cruzi ChEMBL. 11806719
Ki (binding) = 2 nM Inhibitory activity against cruzain, the major cysteine protease found in T. cruzi ChEMBL. 11806719
Ki (binding) = 44 nM Inhibitory activity of the compound against human Cathepsin L ChEMBL. 11806719
Ki (binding) = 44 nM Inhibitory activity of the compound against human Cathepsin L ChEMBL. 11806719
Ki (binding) = 1300 nM Inhibitory activity of the compound against human Cathepsin B ChEMBL. 11806719
Ki (binding) = 1300 nM Inhibitory activity of the compound against human Cathepsin B ChEMBL. 11806719

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.