Detailed information for compound 288824

Basic information

Technical information
  • TDR Targets ID: 288824
  • Name: N-(2-dimethylaminoethyl)-4-[(4-formamido-1-me thylimidazole-2-carbonyl)amino]-1-methylimida zole-2-carboxamide
  • MW: 362.387 | Formula: C15H22N8O3
  • H donors: 3 H acceptors: 5 LogP: -0.63 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=CNc1nc(n(c1)C)C(=O)Nc1nc(n(c1)C)C(=O)NCCN(C)C
  • InChi: 1S/C15H22N8O3/c1-21(2)6-5-16-14(25)12-19-11(8-23(12)4)20-15(26)13-18-10(17-9-24)7-22(13)3/h7-9H,5-6H2,1-4H3,(H,16,25)(H,17,24)(H,20,26)
  • InChiKey: MUFFRHONDRWNDJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-dimethylaminoethyl)-4-[(4-formamido-1-methyl-imidazole-2-carbonyl)amino]-1-methyl-imidazole-2-carboxamide
  • N-(2-dimethylaminoethyl)-4-[[(4-formamido-1-methyl-2-imidazolyl)-oxomethyl]amino]-1-methyl-2-imidazolecarboxamide
  • N-(2-dimethylaminoethyl)-4-[(4-formamido-1-methyl-imidazol-2-yl)carbonylamino]-1-methyl-imidazole-2-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii glycosyl transferase, group 4 family protein 0.2049 0.0418 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0001 0.0021
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0001 0.003
Loa Loa (eye worm) hypothetical protein 0.003 0.0004 0.0106
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0003 0.0075
Echinococcus multilocularis UDP N acetylglucosamine dolichyl phosphate 0.2049 0.0418 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0005 0.0123
Echinococcus granulosus chromobox protein 1 0.0069 0.0012 0.0297
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0006 0.0132
Schistosoma mansoni hypothetical protein 0.0041 0.0006 0.0149
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0002 0.0037
Brugia malayi ecdysteroid receptor 0.001 0 0.0002
Schistosoma mansoni zinc finger protein 0.0021 0.0003 0.0054
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.0018 0.0017
Echinococcus granulosus dnaJ subfamily B 0.0407 0.0082 0.1952
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0007 0.0163
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0011 0.0262
Loa Loa (eye worm) steroid hormone receptor 0.001 0 0.0006
Plasmodium vivax N-acetylglucosamine-1-phosphate transferase, putative 0.2049 0.0418 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0008 0.018
Schistosoma mansoni cpg binding protein 0.0029 0.0004 0.0091
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0001 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0 0.0002
Brugia malayi CHD4 protein 0.0015 0.0001 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0 0.0006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0011 0.026
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.0018 0.0017
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0028
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0 0.0006
Brugia malayi chromobox protein homolog 3 0.0039 0.0006 0.0144
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0001 0.0009
Loa Loa (eye worm) RNA binding protein 0.0063 0.0011 0.0266
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0007 0.015
Loa Loa (eye worm) hypothetical protein 0.0042 0.0007 0.0163
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0 0.0006
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0011 0.0266
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0 0.0002
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0006 0.0129
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0001 0.0006
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0011 0.026
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0001 0.0012
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0001 0.0008
Schistosoma mansoni chromobox protein 0.0011 0.0001 0.0006
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0006 0.0141
Schistosoma mansoni zinc finger protein 0.0015 0.0001 0.0025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0002 0.0032
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0001 0.0012
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0011 0.0256
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0001 0.0008
Brugia malayi Bromodomain containing protein 0.0076 0.0014 0.0327
Echinococcus multilocularis chromobox protein 1 0.0069 0.0012 0.0297
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0012 0.0285
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0001 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0 0.0002
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0008 0.0196
Treponema pallidum phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) 1.8556 0.38 1
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0001 0.0008
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0011 0.0256
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0008 0.018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0 0.0002
Echinococcus granulosus FTZ F1 alpha 0.001 0 0.0006
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0002 0.0034
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0006 0.0005
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0001 0.0009
Brugia malayi CHE-14 protein 0.0042 0.0007 0.0159
Onchocerca volvulus 0.0011 0.0001 0.0006
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0001 0.0008
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0001 0.0021
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0001 0.0034
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.0027 0.0643
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0 0.0006
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0001 0.0021
Echinococcus granulosus GPCR family 2 0.0016 0.0001 0.0034
Loa Loa (eye worm) hypothetical protein 0.2049 0.0418 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0008 0.02
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0007 0.0163
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.0018 0.0017
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.0016 0.0015
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0034
Loa Loa (eye worm) hypothetical protein 0.0039 0.0006 0.0147
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0007 0.015
Plasmodium falciparum thioredoxin reductase 0.0013 0.0001 0.0008
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0006 0.0121
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0002 0.0032
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0001 0.0015
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.0018 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0006
Loa Loa (eye worm) hypothetical protein 0.0041 0.0006 0.0155
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0018 0.0433
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0008 0.018
Loa Loa (eye worm) hypothetical protein 0.0044 0.0007 0.0173
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0003 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0 0.0002
Trypanosoma cruzi ISWI complex protein 0.0015 0.0001 0.0011
Giardia lamblia UDP-N-acetylglucosamine-dolichyl-phosphateN-acetylglucosaminephosphotransferase 0.2049 0.0418 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0 0.0006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0 0.0006
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.2049 0.0418 1
Echinococcus multilocularis chromobox protein 2 0.0011 0.0001 0.0012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0002 0.0032
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0003 0.0069
Toxoplasma gondii thioredoxin reductase 0.0038 0.0006 0.0129
Brugia malayi glutathione reductase 0.0038 0.0006 0.0138
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0001 0.0013
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.0027 0.0643
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0012
Echinococcus multilocularis protein dispatched 1 0.0048 0.0008 0.0192
Leishmania major hypothetical protein, conserved 0.0015 0.0001 0.0011
Brugia malayi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.2049 0.0418 1
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0028
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0 0.0006
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0002 0.0043
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0018 0.0437
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.0016 0.0015
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0006 0.0132
Mycobacterium ulcerans undecapaprenyl-phosphate alpha-N-acetylglucosaminyltransferase Rfe 0.2049 0.0418 0.0417
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0002 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0 0.0002
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0008 0.018
Mycobacterium tuberculosis Probable reductase 0.0086 0.0016 0.0015
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0006 0.0144
Brugia malayi Nuclear hormone receptor-like 1 0.001 0 0.0002
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0007 0.0163
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0002 0.004
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0011 0.0266
Plasmodium falciparum UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.2049 0.0418 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0001 0.0009
Trypanosoma brucei ISWI complex protein 0.0015 0.0001 0.0011
Echinococcus granulosus chromobox protein 1 0.0069 0.0012 0.0297
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0004 0.0097
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0001 0.0009
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0043
Wolbachia endosymbiont of Brugia malayi phospho-N-acetylmuramoyl-pentapeptide-transferase 4.8818 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0004 0.0079
Schistosoma mansoni hypothetical protein 0.0011 0.0001 0.0006
Leishmania major trypanothione reductase 0.0038 0.0006 0.0121
Onchocerca volvulus 0.0012 0.0001 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0006
Schistosoma mansoni bromodomain containing protein 0.0065 0.0011 0.0268
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.2049 0.0418 1
Loa Loa (eye worm) glutathione reductase 0.0038 0.0006 0.0141
Echinococcus multilocularis protein patched 0.0042 0.0007 0.0163
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0001 0.0015
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0 0.0002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0002 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0006
Trypanosoma cruzi ISWI complex protein 0.0015 0.0001 0.0011
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0001 0.0021
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0001 0.003
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0007 0.0156
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0 0.0006
Brugia malayi CXXC zinc finger family protein 0.0029 0.0004 0.0093
Echinococcus granulosus ecdysone induced protein 78C 0.001 0 0.0006
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0006
Schistosoma mansoni hypothetical protein 0.0015 0.0001 0.0025
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0001 0.0034
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.001 0.0222
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0028
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0001 0.0034
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0011 0.026
Brugia malayi nuclear receptor NHR-88 0.001 0 0.0002
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0007 0.0163
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0 0.0006
Entamoeba histolytica UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.2049 0.0418 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0 0.0006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0002 0.0032
Loa Loa (eye worm) helicase 0.0011 0.0001 0.0012
Brugia malayi Protein cec-1. 0.0011 0.0001 0.0009
Echinococcus granulosus Chromobox protein 3 0.0011 0.0001 0.0012
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0006 0.0141
Schistosoma mansoni cpg binding protein 0.0032 0.0005 0.0108
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.0016 0.0015
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.2049 0.0418 1
Schistosoma mansoni hypothetical protein 0.0034 0.0005 0.0117
Chlamydia trachomatis phospho-N-acetylmuramoyl-pentapeptide-transferase 1.8556 0.38 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0002 0.0037
Loa Loa (eye worm) hypothetical protein 0.0038 0.0006 0.0144
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0002 0.0032
Echinococcus granulosus zinc finger protein 0.0021 0.0003 0.006
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0011 0.0266
Echinococcus granulosus expressed conserved protein 0.0092 0.0017 0.0408
Plasmodium falciparum glutathione reductase 0.0038 0.0006 0.0129
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0012
Echinococcus multilocularis chromobox protein 1 0.0069 0.0012 0.0297
Loa Loa (eye worm) hypothetical protein 0.0052 0.0009 0.0209
Echinococcus multilocularis FTZ F1 alpha 0.001 0 0.0006
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0034
Onchocerca volvulus 0.0029 0.0004 0.0091
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0001 0.0028
Schistosoma mansoni chromobox protein 0.0069 0.0012 0.0291
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0012
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0002 0.0043
Echinococcus multilocularis GPCR, family 2 0.0016 0.0001 0.0034
Brugia malayi PHD-finger family protein 0.0026 0.0004 0.0083
Brugia malayi SET domain containing protein 0.0012 0.0001 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0 0.0002
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0018 0.0437
Leishmania major UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.2049 0.0418 1
Echinococcus granulosus Chromo domain 0.0011 0.0001 0.0012
Trypanosoma brucei trypanothione reductase 0.0038 0.0006 0.0121
Brugia malayi Heterochromatin protein 1 0.0069 0.0012 0.0293
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0012
Mycobacterium ulcerans phospho-N-acetylmuramoyl-pentapeptide-transferase 4.8818 1 1
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0001 0.0012
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0001 0.0006
Plasmodium falciparum glutathione reductase 0.0013 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0006
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0001 0.0013
Mycobacterium tuberculosis Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 4.8818 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0006 0.0135
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0 0.0002
Brugia malayi Bromodomain containing protein 0.0038 0.0006 0.014
Trypanosoma brucei UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.2049 0.0418 1
Brugia malayi Thioredoxin reductase 0.0038 0.0006 0.0138
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0001 0.0013
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0018 0.0425
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0012 0.0297
Brugia malayi TAR-binding protein 0.0063 0.0011 0.0262
Schistosoma mansoni hypothetical protein 0.0021 0.0002 0.0051
Echinococcus multilocularis dnaJ subfamily B 0.0407 0.0082 0.1952
Loa Loa (eye worm) hypothetical protein 0.007 0.0013 0.0302
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0012
Echinococcus multilocularis cpg binding protein 0.0032 0.0005 0.0114
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0 0.0005
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0001 0.0008
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0012 0.0285
Plasmodium vivax glutathione reductase, putative 0.0038 0.0006 0.0129
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0008 0.0174
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.2049 0.0418 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0001 0.0034
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0008 0.0196
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0002 0.0034
Schistosoma mansoni cpg binding protein 0.0032 0.0005 0.0108
Schistosoma mansoni hypothetical protein 0.0041 0.0006 0.0149
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0001 0.0024
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0012
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0 0.0006
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0 0.0006
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0001 0.003
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0001 0.0013
Echinococcus granulosus UDP N acetylglucosamine dolichyl phosphate 0.2049 0.0418 1
Onchocerca volvulus 0.003 0.0004 0.01
Schistosoma mansoni chromobox protein 0.0011 0.0001 0.0006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0002 0.0032
Schistosoma mansoni hypothetical protein 0.0041 0.0006 0.0149
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0001 0.003
Echinococcus granulosus tar DNA binding protein 0.0063 0.0011 0.0266
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0011 0.026
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0 0.0006
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0001 0.0034
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0008 0.0174
Trichomonas vaginalis glucosaminephosphotransferase, putative 0.2049 0.0418 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0001 0.0017
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0001 0.0034
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0001 0.0021
Loa Loa (eye worm) hypothetical protein 0.0098 0.0018 0.0437
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0019 0.0439
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0001 0.003
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0008 0.0176
Brugia malayi isocitrate dehydrogenase 0.0016 0.0001 0.003
Brugia malayi MH2 domain containing protein 0.0119 0.0023 0.0536
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0023 0.0539
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0028
Onchocerca volvulus 0.0011 0.0001 0.0006
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0002 0.0057
Schistosoma mansoni hypothetical protein 0.0407 0.0082 0.1947
Echinococcus granulosus cpg binding protein 0.0032 0.0005 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0004 0.0079
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0001 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0006
Schistosoma mansoni hypothetical protein 0.0041 0.0006 0.0149
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0034
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0001 0.0017
Brugia malayi steroid hormone receptor 0.001 0 0.0002
Echinococcus granulosus chromobox protein 2 0.0011 0.0001 0.0012
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0001 0.0021
Schistosoma mansoni patched 1 0.0042 0.0007 0.0157
Echinococcus multilocularis Chromo domain 0.0011 0.0001 0.0012
Onchocerca volvulus 0.2049 0.0418 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0011 0.026
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0001 0.0008
Brugia malayi RNA binding protein 0.0063 0.0011 0.0262
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0008 0.018
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0001 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0006 0.0135
Brugia malayi hypothetical protein 0.0011 0.0001 0.0009
Echinococcus multilocularis zinc finger protein 0.0021 0.0003 0.006
Brugia malayi nuclear hormone receptor 0.001 0 0.0002
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0001 0.0006
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0002 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0 0.0002
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0001 0.0008
Brugia malayi Steroid receptor seven-up type 2 0.001 0 0.0002
Plasmodium falciparum thioredoxin reductase 0.0038 0.0006 0.0129
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0001 0.0017
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0006 0.0144
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0001 0.0009
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0011 0.0248
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0007 0.0151
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0005 0.0119
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0008 0.0174
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0023 0.0539
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0008 0.02
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0 0.0006
Schistosoma mansoni chromobox protein 0.0069 0.0012 0.0291
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0 0.0002
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0034
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0001 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0034
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0807 0.0164 0.3912
Echinococcus multilocularis expressed conserved protein 0.0092 0.0017 0.0408
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0002 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0 0.0006
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.0016 0.0015

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 500 uM Inhibitory activity against K-562 (human chronic myeloid Leukemia) cells ChEMBL. 8464041
IC50 (functional) > 500 uM Inhibitory activity against K-562 (human chronic myeloid Leukemia) cells ChEMBL. 8464041
K app (binding) = 0.17 M-1 Apparent binding constant to poly (dA.dT) DNA was evaluated by measuring the loss of ethidium fluorescence ChEMBL. 8464041
K app (binding) = 0.23 M-1 Apparent binding constant to poly (dG.dC) DNA was evaluated by measuring the loss of ethidium fluorescence ChEMBL. 8464041
K app (binding) = 0.32 M-1 Apparent binding constant to calf thymus DNA was evaluated by measuring the loss of ethidium fluorescence ChEMBL. 8464041
K app (functional) = 0.4 M-1 Apparent binding constant to T4 coliphage DNA was evaluated by measuring the loss of ethidium fluorescence ChEMBL. 8464041

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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