Detailed information for compound 304687

Basic information

Technical information
  • TDR Targets ID: 304687
  • Name: 3-chloro-4-[(4R,5S)-4-(2-chloro-4-hydroxyphen yl)-2-methyl-4,5-dihydro-1H-imidazol-5-yl]phe nol
  • MW: 337.201 | Formula: C16H14Cl2N2O2
  • H donors: 3 H acceptors: 2 LogP: 2.99 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(c(c1)Cl)[C@H]1N=C(N[C@H]1c1ccc(cc1Cl)O)C
  • InChi: 1S/C16H14Cl2N2O2/c1-8-19-15(11-4-2-9(21)6-13(11)17)16(20-8)12-5-3-10(22)7-14(12)18/h2-7,15-16,21-22H,1H3,(H,19,20)/t15-,16+
  • InChiKey: HCEPTCHLZDJMON-IYBDPMFKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-chloro-4-[(4R,5S)-4-(2-chloro-4-hydroxy-phenyl)-2-methyl-4,5-dihydro-1H-imidazol-5-yl]phenol
  • 3-chloro-4-[(4S,5R)-5-(2-chloro-4-hydroxy-phenyl)-2-methyl-2-imidazolin-4-yl]phenol
  • 3-chloro-4-[(4S,5R)-5-(2-chloro-4-hydroxyphenyl)-2-methyl-4,5-dihydro-3H-imidazol-4-yl]phenol
  • 3-chloro-4-[(4S,5R)-5-(2-chloro-4-hydroxy-phenyl)-2-methyl-4,5-dihydro-3H-imidazol-4-yl]phenol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0037 0.0057 0.0176
Toxoplasma gondii PAN domain-containing protein 0.0122 0.0412 0.0912
Brugia malayi hypothetical protein 0.0142 0.0497 0.2801
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0041 0.0074 0.0074
Schistosoma mansoni hypothetical protein 0.0196 0.0726 0.2158
Loa Loa (eye worm) hypothetical protein 0.0092 0.0289 0.156
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0091 0.0197
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0028 0.0028
Entamoeba histolytica hypothetical protein 0.0072 0.0201 0.1475
Brugia malayi Trypsin family protein 0.0373 0.1473 0.8624
Trypanosoma cruzi hypothetical protein, conserved 0.0206 0.0768 0.451
Brugia malayi Trypsin family protein 0.0092 0.0289 0.156
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0091 0.028
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0092 0.0289 0.0808
Loa Loa (eye worm) PAN domain-containing protein 0.0122 0.0412 0.2293
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0028 0.0085
Brugia malayi MH2 domain containing protein 0.0119 0.04 0.222
Loa Loa (eye worm) pyruvate kinase 0.0065 0.0172 0.0863
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0034 0.0044 0.1131
Schistosoma mansoni hypothetical protein 0.012 0.0407 0.1174
Entamoeba histolytica hypothetical protein 0.0072 0.0201 0.1475
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0291 0.1126 1
Loa Loa (eye worm) PAN domain-containing protein 0.0122 0.0412 0.2293
Brugia malayi AMP-binding enzyme family protein 0.0117 0.0391 0.217
Brugia malayi PAN domain containing protein 0.0122 0.0412 0.2293
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0034 0.0044 0.026
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0034 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.0092 0.0289 0.156
Toxoplasma gondii pyruvate kinase PyK1 0.0065 0.0172 0.0325
Loa Loa (eye worm) RNA binding protein 0.0068 0.0185 0.0938
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0049 0.0105 0.0392
Schistosoma mansoni hypothetical protein 0.005 0.0111 0.0259
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0034 0.0044 0.1131
Echinococcus granulosus FTZ F1 alpha 0.003 0.0028 0.0085
Loa Loa (eye worm) hypothetical protein 0.0122 0.0412 0.2293
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0024 0.0619
Mycobacterium ulcerans acyl-CoA synthetase 0.0034 0.0044 0.1131
Loa Loa (eye worm) hypothetical protein 0.0034 0.0044 0.0099
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0185 0.0486
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0034 0.0044 0.1131
Mycobacterium ulcerans acyl-CoA synthetase 0.0034 0.0044 0.1131
Toxoplasma gondii PAN domain-containing protein 0.0122 0.0412 0.0912
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0041 0.0009
Onchocerca volvulus 0.0122 0.0412 0.2293
Onchocerca volvulus 0.0031 0.0031 0.0023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0091 0.0091
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0092 0.0289 0.0808
Echinococcus granulosus pyruvate kinase 0.0065 0.0172 0.0528
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0028 0.0085
Echinococcus multilocularis pyruvate kinase 0.0065 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0041 0.0074 0.0277
Schistosoma mansoni hypothetical protein 0.0092 0.0289 0.0808
Onchocerca volvulus 0.0122 0.0412 0.2293
Mycobacterium ulcerans pyruvate kinase 0.0065 0.0172 0.4403
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0087 0.0267 0.6826
Loa Loa (eye worm) pyruvate kinase 0.0065 0.0172 0.0863
Onchocerca volvulus 0.0122 0.0412 0.2293
Echinococcus granulosus pyruvate kinase 0.0033 0.004 0.0122
Echinococcus granulosus tar DNA binding protein 0.0068 0.0185 0.0566
Mycobacterium ulcerans acyl-CoA synthetase 0.0034 0.0044 0.1131
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0125 0.0426 0.2379
Brugia malayi Kringle domain containing protein 0.0428 0.1703 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0034 0.0044 0.1131
Loa Loa (eye worm) hypothetical protein 0.0087 0.0267 0.1429
Schistosoma mansoni pyruvate kinase 0.0065 0.0172 0.0447
Loa Loa (eye worm) hypothetical protein 0.0291 0.1126 0.6556
Echinococcus multilocularis Niemann Pick C1 protein 0.0291 0.1126 0.1126
Schistosoma mansoni cercarial elastase (S01 family) 0.0092 0.0289 0.0808
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0034 0.0044 0.0011
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0041 0.0242
Echinococcus multilocularis glycoprotein Antigen 5 0.0092 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0117 0.0391 0.217
Schistosoma mansoni cercarial elastase (S01 family) 0.0092 0.0289 0.0808
Echinococcus multilocularis expressed protein 0.0049 0.0105 0.0105
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0373 0.1473 0.4468
Loa Loa (eye worm) hypothetical protein 0.0092 0.0289 0.156
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0028 0.0028
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0034 0.0044 0.0099
Schistosoma mansoni cercarial elastase (S01 family) 0.0092 0.0289 0.0808
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0034 0.0044 0.1131
Toxoplasma gondii PAN domain-containing protein 0.0122 0.0412 0.0912
Brugia malayi hypothetical protein 0.0072 0.0201 0.1037
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0034 0.0044 0.0027
Brugia malayi Niemann-Pick C1 protein precursor 0.0291 0.1126 0.6556
Loa Loa (eye worm) hypothetical protein 0.0087 0.0267 0.1429
Echinococcus granulosus Niemann Pick C1 protein 0.0291 0.1126 0.3452
Schistosoma mansoni cercarial elastase (S01 family) 0.0092 0.0289 0.0808
Brugia malayi PAN domain containing protein 0.0122 0.0412 0.2293
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0041 0.0074 0.0277
Echinococcus multilocularis protein patched 0.0125 0.0426 0.0426
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0111 0.0342
Toxoplasma gondii PAN/Apple domain-containing protein 0.0122 0.0412 0.0912
Onchocerca volvulus 0.0122 0.0412 0.2293
Onchocerca volvulus 0.0092 0.0289 0.156
Brugia malayi Trypsin-like protease protein 5 0.0092 0.0289 0.156
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0041 0.0009
Brugia malayi TAR-binding protein 0.0068 0.0185 0.0938
Leishmania major acetyl-CoA synthetase, putative 0.0034 0.0044 0.026
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0034 0.0044 0.1131
Leishmania major hypothetical protein, conserved 0.0428 0.1703 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0201 0.0201
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0092 0.0289 0.0808
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0111 0.0501
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0091 0.0381
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0028 0.0085
Onchocerca volvulus Pyruvate kinase homolog 0.0065 0.0172 0.0863
Loa Loa (eye worm) hypothetical protein 0.0117 0.0391 0.217
Onchocerca volvulus 0.0034 0.0044 0.0099
Echinococcus granulosus Niemann Pick C1 protein 0.0416 0.1653 0.5065
Echinococcus granulosus transcription factor btf3 0.0034 0.0041 0.0126
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0092 0.0289 0.0808
Toxoplasma gondii PAN domain-containing protein 0.0122 0.0412 0.0912
Loa Loa (eye worm) hypothetical protein 0.0373 0.1473 0.8624
Schistosoma mansoni cercarial elastase (S01 family) 0.0092 0.0289 0.0808
Toxoplasma gondii microneme protein MIC17C 0.0122 0.0412 0.0912
Schistosoma mansoni cercarial elastase (S01 family) 0.0092 0.0289 0.0808
Giardia lamblia Pyruvate kinase 0.0065 0.0172 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.0412 0.2293
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0185 0.0486
Brugia malayi AMP-binding enzyme family protein 0.0117 0.0391 0.217
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0092 0.0289 0.0886
Onchocerca volvulus 0.0373 0.1473 0.8624
Echinococcus granulosus Protein patched homolog 1 0.0125 0.0426 0.1307
Brugia malayi AMP-binding enzyme family protein 0.0117 0.0391 0.217
Echinococcus multilocularis pyruvate kinase 0.0065 0.0172 0.0172
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0159 0.0568 0.3227
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.04 0.222
Trichomonas vaginalis pyruvate kinase, putative 0.0065 0.0172 0.4042
Brugia malayi Calcitonin receptor-like protein seb-1 0.0159 0.0568 0.3227
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0111 0.0501
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0008
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0041 0.0004
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0091 0.0381
Schistosoma mansoni hypothetical protein 0.012 0.0407 0.1174
Plasmodium vivax pyruvate kinase, putative 0.0065 0.0172 0.0797
Loa Loa (eye worm) hypothetical protein 0.0087 0.0267 0.1429
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0091 0.0197
Toxoplasma gondii PAN domain-containing protein 0.1002 0.4121 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0135 0.0641
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0028 0.0085
Echinococcus granulosus lamin dm0 0.0031 0.0031 0.0096
Echinococcus multilocularis survival motor neuron protein 1 0.0274 0.1052 0.1052
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0041 0.0242
Echinococcus multilocularis protein dispatched 1 0.0143 0.0501 0.0501
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0082 0.0247 0.6314
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0028 0.0028
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0034 0.0044 0.1131
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0034 0.0044 0.1131
Loa Loa (eye worm) hypothetical protein 0.0428 0.1703 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0117 0.0391 0.3226
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0117 0.0391 1
Trichomonas vaginalis pyruvate kinase, putative 0.0065 0.0172 0.4042
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0117 0.0391 1
Onchocerca volvulus Huntingtin homolog 0.0142 0.0497 0.2801
Plasmodium falciparum cysteine repeat modular protein 1 0.0428 0.1703 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0111 0.0111
Trypanosoma cruzi pyruvate kinase 2, putative 0.0065 0.0172 0.1012
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0031 0.0023
Echinococcus multilocularis pyruvate kinase 0.0033 0.004 0.004
Schistosoma mansoni microtubule-associated protein tau 0.0798 0.3262 1
Leishmania major basic transcription factor 3a, putative 0.0034 0.0041 0.0242
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0041 0.0081
Echinococcus multilocularis musashi 0.0031 0.0031 0.0031
Schistosoma mansoni cercarial elastase (S01 family) 0.0092 0.0289 0.0808
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0034 0.0044 0.0011
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0117 0.0391 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0082 0.0247 0.6314
Onchocerca volvulus Pyruvate kinase homolog 0.0065 0.0172 0.0863
Loa Loa (eye worm) trypsin family protein 0.0092 0.0289 0.156
Loa Loa (eye worm) hypothetical protein 0.0092 0.0289 0.156
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0091 0.028
Onchocerca volvulus 0.0281 0.1084 0.6302
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0111 0.0342
Schistosoma mansoni acetyl-CoA synthetase 0.0034 0.0044 0.0051
Loa Loa (eye worm) hypothetical protein 0.0142 0.0497 0.2801
Onchocerca volvulus 0.0092 0.0289 0.156
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0122 0.0412 0.0912
Mycobacterium ulcerans hypothetical protein 0.0092 0.0289 0.7388
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0117 0.0391 1
Echinococcus granulosus microtubule associated protein 2 0.0798 0.3262 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0117 0.0391 0.2297
Echinococcus multilocularis enteropeptidase 0.0092 0.0289 0.0289
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0034 0.0044 0.1131
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0122 0.0412 0.2293
Brugia malayi hypothetical protein 0.0092 0.0289 0.156
Schistosoma mansoni hypothetical protein 0.005 0.0111 0.0259
Onchocerca volvulus 0.0056 0.0135 0.0641
Loa Loa (eye worm) hypothetical protein 0.0142 0.0497 0.2801
Leishmania major hypothetical protein, conserved 0.0206 0.0768 0.451
Onchocerca volvulus 0.0117 0.0391 0.217
Brugia malayi beta-NAC-like protein 0.0034 0.0041 0.0081
Echinococcus granulosus GPCR family 2 0.005 0.0111 0.0342
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0028 0.0028
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0373 0.1473 0.4468
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0031 0.0023
Schistosoma mansoni hypothetical protein 0.0196 0.0726 0.2158
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0117 0.0391 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0065 0.0172 0.1012
Schistosoma mansoni hypothetical protein 0.012 0.0407 0.1174
Trypanosoma brucei pyruvate kinase 1, putative 0.0065 0.0172 0.1803
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0028 0.0085
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0092 0.0289 0.0808
Echinococcus granulosus sterol regulatory element binding protein 0.0125 0.0426 0.1307
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0091 0.0091
Mycobacterium ulcerans acyl-CoA synthetase 0.0034 0.0044 0.1131
Toxoplasma gondii hypothetical protein 0.0122 0.0412 0.0912
Schistosoma mansoni cercarial elastase (S01 family) 0.0092 0.0289 0.0808
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0092 0.0289 0.0808
Echinococcus multilocularis GPCR, family 2 0.005 0.0111 0.0111
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0092 0.0289 0.0289
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0428 0.1703 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0034 0.0044 0.1131
Toxoplasma gondii propionate-CoA ligase 0.0034 0.0044 0.0011
Echinococcus multilocularis pyruvate kinase 0.0033 0.004 0.004
Brugia malayi PAN domain containing protein 0.0122 0.0412 0.2293
Schistosoma mansoni hypothetical protein 0.005 0.0111 0.0259
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0049 0.0105 0.0392
Mycobacterium ulcerans acetyl-CoA synthetase 0.0034 0.0044 0.1131
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0034 0.0044 0.1131
Schistosoma mansoni cercarial elastase (S01 family) 0.0092 0.0289 0.0808
Onchocerca volvulus 0.0034 0.0044 0.0099
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0082 0.0247 0.6314
Onchocerca volvulus 0.0122 0.0412 0.2293
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0031 0.0023
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0201 0.0617
Brugia malayi Latrophilin receptor protein 2 0.005 0.0111 0.0501
Schistosoma mansoni hypothetical protein 0.0108 0.0357 0.1018
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0034 0.0044 0.1131
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0201 0.0537
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0028 0.0028
Onchocerca volvulus 0.0034 0.0044 0.0099
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0034 0.0044 0.0044
Onchocerca volvulus 0.0031 0.0031 0.0023
Onchocerca volvulus 0.0122 0.0412 0.2293
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0117 0.0391 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0125 0.0426 0.0426
Loa Loa (eye worm) hypothetical protein 0.0065 0.0172 0.0863
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0049 0.0105 0.0462
Trypanosoma cruzi hypothetical protein, conserved 0.0428 0.1703 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0045 0.009 0.0372
Loa Loa (eye worm) hypothetical protein 0.0045 0.009 0.0372
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0034 0.0044 0.1131
Brugia malayi AMP-binding enzyme family protein 0.0034 0.0044 0.0099
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0034 0.0044 0.0136
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0092 0.0289 0.0289
Echinococcus granulosus lamin 0.0031 0.0031 0.0096
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0028 0.0028
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0185 0.0486
Onchocerca volvulus 0.0092 0.0289 0.156
Echinococcus multilocularis geminin 0.0196 0.0726 0.0726
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0065 0.0172 0.4403
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0426 1
Mycobacterium ulcerans hypothetical protein 0.0117 0.0391 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0028 0.0028
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0034 0.0044 0.1131
Entamoeba histolytica acyl-CoA synthetase, putative 0.0117 0.0391 0.3226
Loa Loa (eye worm) hypothetical protein 0.0108 0.0357 0.1965
Echinococcus multilocularis pyruvate kinase 0.0051 0.0115 0.0115
Toxoplasma gondii PAN domain-containing protein 0.1002 0.4121 1
Schistosoma mansoni hypothetical protein 0.005 0.0111 0.0259
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0034 0.0044 0.026
Leishmania major acetyl-CoA synthetase, putative 0.0034 0.0044 0.026
Echinococcus granulosus glycoprotein Antigen 5 0.0092 0.0289 0.0886
Brugia malayi PAN domain containing protein 0.0122 0.0412 0.2293
Brugia malayi PAN domain containing protein 0.0122 0.0412 0.2293
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0028 0.0085
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0041 0.0074 0.0277
Entamoeba histolytica hypothetical protein 0.0072 0.0201 0.1475
Schistosoma mansoni pyruvate kinase 0.0065 0.0172 0.0447
Echinococcus multilocularis Niemann Pick C1 protein 0.0416 0.1653 0.1653
Echinococcus granulosus pyruvate kinase 0.0033 0.004 0.0122
Echinococcus granulosus geminin 0.0196 0.0726 0.2224
Brugia malayi AMP-binding enzyme family protein 0.0034 0.0044 0.0099
Echinococcus multilocularis expressed conserved protein 0.0274 0.1052 0.1052
Onchocerca volvulus 0.0092 0.0289 0.156
Brugia malayi AMP-binding enzyme family protein 0.0034 0.0044 0.0099
Schistosoma mansoni hypothetical protein 0.0041 0.0074 0.0144
Toxoplasma gondii hypothetical protein 0.0122 0.0412 0.0912
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0159 0.0568 0.3227
Mycobacterium ulcerans acyl-CoA synthetase 0.0117 0.0391 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0117 0.0391 1
Echinococcus multilocularis Mastin 0.0092 0.0289 0.0289
Onchocerca volvulus 0.0428 0.1703 1
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0041 0.0074 0.0084
Schistosoma mansoni lamin 0.0031 0.0031 0.0012
Echinococcus granulosus tumor protein p63 0.0327 0.1279 0.392
Mycobacterium ulcerans acyl-CoA synthetase 0.0034 0.0044 0.1131
Loa Loa (eye worm) hypothetical protein 0.0087 0.0267 0.1429
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0044 0.1131
Brugia malayi Trypsin family protein 0.0092 0.0289 0.156
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0185 0.0938
Echinococcus granulosus tissue type plasminogen activator 0.0428 0.1703 0.5221
Echinococcus multilocularis transcription factor btf3 0.0034 0.0041 0.0041
Brugia malayi Pyruvate kinase, muscle isozyme 0.0065 0.0172 0.0863
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0023
Loa Loa (eye worm) pyruvate kinase 0.0065 0.0172 0.0863
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0028 0.0028
Toxoplasma gondii microneme protein, putative 0.0122 0.0412 0.0912
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0041 0.0074 0.0206
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0034 0.0044 0.026
Schistosoma mansoni transcription factor btf3 0.0034 0.0041 0.0042
Schistosoma mansoni hypothetical protein 0.0072 0.0201 0.0537
Echinococcus multilocularis tissue type plasminogen activator 0.0428 0.1703 0.1703
Trichomonas vaginalis antibiotic synthetase, putative 0.0034 0.0044 0.1038
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0041 0.0074 0.0277
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0117 0.0391 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0092 0.0289 0.0808
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0044 0.1131
Schistosoma mansoni hypothetical protein 0.012 0.0407 0.1174
Leishmania major pyruvate kinase 0.0065 0.0172 0.1012
Loa Loa (eye worm) hypothetical protein 0.0092 0.0289 0.156
Toxoplasma gondii kringle domain-containing protein 0.0428 0.1703 0.4077
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0049 0.0105 0.016
Brugia malayi hypothetical protein 0.0274 0.1052 0.6114
Echinococcus granulosus enteropeptidase 0.0092 0.0289 0.0886
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0185 0.0938
Leishmania major 4-coumarate:coa ligase-like protein 0.0117 0.0391 0.2297
Brugia malayi PAN domain containing protein 0.0122 0.0412 0.2293
Onchocerca volvulus 0.0122 0.0412 0.2293
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0185 0.0185
Trypanosoma brucei hypothetical protein, conserved 0.0206 0.0768 1
Plasmodium falciparum acyl-CoA synthetase 0.0087 0.0267 0.1366
Brugia malayi PAN domain containing protein 0.0122 0.0412 0.2293
Schistosoma mansoni hypothetical protein 0.0092 0.0289 0.0808
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0041 0.0967
Loa Loa (eye worm) PAN domain-containing protein 0.0122 0.0412 0.2293
Loa Loa (eye worm) hypothetical protein 0.0274 0.1052 0.6114
Loa Loa (eye worm) hypothetical protein 0.0034 0.0044 0.0099
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0034 0.0044 0.0028
Brugia malayi PAN domain containing protein 0.0122 0.0412 0.2293
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0044 0.1131
Loa Loa (eye worm) hypothetical protein 0.0048 0.0102 0.0443
Schistosoma mansoni cercarial elastase (S01 family) 0.0092 0.0289 0.0808
Brugia malayi Pyruvate kinase, M2 isozyme 0.0065 0.0172 0.0863
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0028 0.0085
Brugia malayi RNA binding protein 0.0068 0.0185 0.0938
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0087 0.0267 0.6826
Leishmania major 4-coumarate:coa ligase-like protein 0.0117 0.0391 0.2297
Brugia malayi intermediate filament protein 0.0031 0.0031 0.0023
Leishmania major pyruvate kinase 0.0065 0.0172 0.1012
Onchocerca volvulus 0.0122 0.0412 0.2293
Trypanosoma cruzi hypothetical protein, conserved 0.0206 0.0768 0.451
Brugia malayi PAN domain containing protein 0.0122 0.0412 0.2293
Loa Loa (eye worm) hypothetical protein 0.0122 0.0412 0.2293
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0091 0.0197
Plasmodium vivax acyl-CoA synthetase, putative 0.0087 0.0267 0.1366
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0296 0.1145 0.3455
Onchocerca volvulus Pyruvate kinase homolog 0.0065 0.0172 0.0863
Schistosoma mansoni hypothetical protein 0.0428 0.1703 0.518
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0044 0.1131
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0185 0.0486
Toxoplasma gondii microneme protein MIC17A 0.0122 0.0412 0.0912
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0034 0.0044 0.0099
Echinococcus multilocularis microtubule associated protein 2 0.0798 0.3262 0.3262
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0034 0.0044 0.026
Loa Loa (eye worm) PAN domain-containing protein 0.0122 0.0412 0.2293
Brugia malayi Trypsin family protein 0.0092 0.0289 0.156
Loa Loa (eye worm) hypothetical protein 0.0153 0.0545 0.3086
Echinococcus granulosus expressed protein 0.0049 0.0105 0.0322
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0092 0.0289 0.0886
Mycobacterium ulcerans acyl-CoA synthetase 0.0034 0.0044 0.1131
Onchocerca volvulus 0.0048 0.0102 0.0443
Plasmodium vivax acetyl-CoA synthetase, putative 0.0034 0.0044 0.0027
Onchocerca volvulus 0.0122 0.0412 0.2293
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0082 0.0247 0.6314
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.04 0.222
Echinococcus granulosus Mastin 0.0092 0.0289 0.0886
Plasmodium falciparum pyruvate kinase 0.0065 0.0172 0.0797
Trypanosoma brucei pyruvate kinase 1 0.0065 0.0172 0.1803
Schistosoma mansoni hypothetical protein 0.0056 0.0135 0.0332
Schistosoma mansoni patched 1 0.0125 0.0426 0.1232
Schistosoma mansoni survival motor neuron protein 0.0056 0.0135 0.0332
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0041 0.0967
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0041 0.0074 0.0206
Trichomonas vaginalis antibiotic synthetase, putative 0.0034 0.0044 0.1038
Loa Loa (eye worm) hypothetical protein 0.0125 0.0426 0.2379
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0185 0.0938
Schistosoma mansoni intermediate filament proteins 0.0031 0.0031 0.0012
Loa Loa (eye worm) hypothetical protein 0.0159 0.0568 0.3227
Mycobacterium leprae Probable pyruvate kinase PykA 0.0065 0.0172 0.369
Loa Loa (eye worm) PAN domain-containing protein 0.0122 0.0412 0.2293
Loa Loa (eye worm) oxidoreductase 0.0034 0.0044 0.0099
Echinococcus granulosus intermediate filament protein 0.0031 0.0031 0.0096
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0034 0.0044 0.0042
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0049 0.0105 0.0462
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0122 0.0412 0.2293
Echinococcus multilocularis lamin dm0 0.0031 0.0031 0.0031
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0102 0.023
Entamoeba histolytica acyl-coA synthetase, putative 0.0117 0.0391 0.3226
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0034 0.0044 0.0099
Mycobacterium ulcerans acyl-CoA synthetase 0.0034 0.0044 0.1131
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0041 0.0967
Echinococcus granulosus expressed conserved protein 0.0274 0.1052 0.3224
Schistosoma mansoni lamin 0.0031 0.0031 0.0012
Brugia malayi CHE-14 protein 0.0125 0.0426 0.2379
Toxoplasma gondii TIM10 family protein, putative 0.0049 0.0105 0.016
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0034 0.0044 0.0099
Loa Loa (eye worm) hypothetical protein 0.005 0.0111 0.0501
Entamoeba histolytica hypothetical protein 0.0072 0.0201 0.1475
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0034 0.0044 0.1131
Loa Loa (eye worm) hypothetical protein 0.0122 0.0412 0.2293
Echinococcus granulosus pyruvate kinase 0.0065 0.0172 0.0528
Brugia malayi PAN domain containing protein 0.0122 0.0412 0.2293
Toxoplasma gondii subtilisin SUB12 0.0122 0.0412 0.0912
Loa Loa (eye worm) hypothetical protein 0.0122 0.0412 0.2293
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0087 0.0267 1
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0049 0.0105 0.0239
Toxoplasma gondii microneme protein MIC17B 0.0122 0.0412 0.0912
Entamoeba histolytica pyruvate kinase, putative 0.0045 0.009 0.0449
Schistosoma mansoni pyruvate kinase 0.0033 0.004 0.0038
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0028 0.0085
Onchocerca volvulus 0.0122 0.0412 0.2293
Echinococcus multilocularis tumor protein p63 0.0327 0.1279 0.1279
Echinococcus granulosus survival motor neuron protein 1 0.0274 0.1052 0.3225
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0034 0.0044 0.1131
Brugia malayi AMP-binding enzyme family protein 0.0034 0.0044 0.0099
Toxoplasma gondii microneme protein MIC4 0.0122 0.0412 0.0912
Brugia malayi latrophilin 2 splice variant baaae 0.0108 0.0357 0.1965
Loa Loa (eye worm) hypothetical protein 0.0373 0.1473 0.8624
Loa Loa (eye worm) hypothetical protein 0.0087 0.0267 0.1429
Onchocerca volvulus 0.0034 0.0044 0.0099
Onchocerca volvulus Huntingtin homolog 0.0142 0.0497 0.2801
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0117 0.0391 1
Loa Loa (eye worm) hypothetical protein 0.0117 0.0391 0.217
Brugia malayi Protein kinase domain containing protein 0.0428 0.1703 1
Echinococcus granulosus pyruvate kinase 0.0033 0.004 0.0122
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0034 0.0044 0.026
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0092 0.0289 0.156
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0185 0.0486
Echinococcus granulosus transmembrane protease serine 3 0.0092 0.0289 0.0886
Mycobacterium ulcerans acyl-CoA synthetase 0.0117 0.0391 1
Echinococcus multilocularis pyruvate kinase 0.0033 0.004 0.004
Loa Loa (eye worm) TK/ROR protein kinase 0.0428 0.1703 1
Onchocerca volvulus 0.0092 0.0289 0.156
Echinococcus multilocularis lamin 0.0031 0.0031 0.0031
Echinococcus multilocularis transmembrane protease serine 3 0.0092 0.0289 0.0289
Brugia malayi hypothetical protein 0.0037 0.0057 0.0176
Onchocerca volvulus 0.0122 0.0412 0.2293

Activities

Activity type Activity value Assay description Source Reference
Relative activation (functional) = 0 % Activation of luciferase expression in MCF-7-2a cells relative to estradiol (E2) ChEMBL. 14761193
Relative activation (functional) = 0 % Activation of luciferase expression in MCF-7-2a cells relative to estradiol (E2) ChEMBL. 14761193

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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