Detailed information for compound 304758

Basic information

Technical information
  • TDR Targets ID: 304758
  • Name: 1-methyl-3-(2-methylprop-2-enyl)-7H-purine-2, 6-dione
  • MW: 220.228 | Formula: C10H12N4O2
  • H donors: 1 H acceptors: 3 LogP: 0.88 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=C)Cn1c(=O)n(C)c(=O)c2c1[nH]cn2
  • InChi: 1S/C10H12N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5H,1,4H2,2-3H3,(H,11,12)
  • InChiKey: KFBAODNODTVGFD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-methyl-3-(2-methylallyl)-7H-purine-2,6-dione
  • 1-methyl-3-(2-methylallyl)-7H-purine-2,6-quinone
  • 1-methyl-3-(2-methylprop-2-enyl)-7H-purine-2,6-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.005 0.0716
Mycobacterium ulcerans hypothetical protein 0.0076 0.0612 1
Toxoplasma gondii PAN domain-containing protein 0.098 0.9939 1
Schistosoma mansoni ap endonuclease 0.0022 0.005 0.009
Loa Loa (eye worm) hypothetical protein 0.0048 0.0323 0.0714
Entamoeba histolytica hypothetical protein 0.0035 0.0188 0.18
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0065 0.0223
Loa Loa (eye worm) hypothetical protein 0.0105 0.0913 0.2037
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.1239 0.3133
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0317 0.4518
Echinococcus granulosus enteropeptidase 0.0076 0.0612 0.1534
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0233 0.223 0.2222
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0076 0.0612 0.1351
Echinococcus granulosus tissue type plasminogen activator 0.0219 0.2083 0.5283
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0548 0.8953
Onchocerca volvulus 0.0105 0.0913 0.1928
Brugia malayi hypothetical protein 0.0035 0.0188 0.0399
Onchocerca volvulus 0.0076 0.0612 0.1243
Loa Loa (eye worm) hypothetical protein 0.0105 0.0913 0.2037
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0076 0.0612 0.1351
Schistosoma mansoni zinc finger protein 0.0025 0.0089 0.0176
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0065 0.0991
Loa Loa (eye worm) hypothetical protein 0.0105 0.0913 0.2037
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0425 0.0931
Loa Loa (eye worm) PAN domain-containing protein 0.0105 0.0913 0.2037
Brugia malayi mbt repeat family protein 0.0058 0.0425 0.0931
Echinococcus multilocularis tissue type plasminogen activator 0.0219 0.2083 0.2075
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0815 0.0806
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.037 0.0808
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0065 0.0223
Echinococcus granulosus Mastin 0.0076 0.0612 0.1534
Echinococcus multilocularis protein patched 0.0041 0.0251 0.0241
Schistosoma mansoni cercarial elastase (S01 family) 0.0076 0.0612 0.1351
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.037 0.0361
Echinococcus multilocularis protein dispatched 1 0.0047 0.0311 0.0301
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0065 0.019
Schistosoma mansoni ap endonuclease 0.0022 0.005 0.009
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0065 0.0123
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0076 0.0612 0.1351
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0219 0.2083 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0135
Leishmania major hypothetical protein, conserved 0.0219 0.2083 1
Loa Loa (eye worm) PAN domain-containing protein 0.0105 0.0913 0.2037
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0076 0.0612 0.1351
Loa Loa (eye worm) hypothetical protein 0.0076 0.0612 0.1361
Schistosoma mansoni cpg binding protein 0.0028 0.0115 0.0235
Schistosoma mansoni cpg binding protein 0.0032 0.0155 0.0326
Onchocerca volvulus 0.0105 0.0913 0.1928
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0548 0.2566
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0508 0.0498
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0548 1
Loa Loa (eye worm) hypothetical protein 0.045 0.4466 1
Loa Loa (eye worm) trypsin family protein 0.0076 0.0612 0.1361
Schistosoma mansoni cercarial elastase (S01 family) 0.0076 0.0612 0.1351
Mycobacterium ulcerans hypothetical protein 0.0023 0.0065 0.0991
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.037 0.0808
Brugia malayi PAN domain containing protein 0.0105 0.0913 0.2027
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0065 0.1107
Toxoplasma gondii microneme protein MIC17A 0.0105 0.0913 0.0873
Toxoplasma gondii PAN domain-containing protein 0.0105 0.0913 0.0873
Echinococcus multilocularis Mastin 0.0076 0.0612 0.0602
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.037 0.0918
Schistosoma mansoni cercarial elastase (S01 family) 0.0076 0.0612 0.1351
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.005 1
Brugia malayi Muscleblind-like protein 0.0172 0.1602 0.3572
Entamoeba histolytica hypothetical protein 0.0035 0.0188 0.18
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0317 0.4518
Brugia malayi Trypsin-like protease protein 5 0.0076 0.0612 0.1351
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0548 0.8953
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0065 0.019
Toxoplasma gondii hypothetical protein 0.0105 0.0913 0.0873
Echinococcus multilocularis cpg binding protein 0.0032 0.0155 0.0145
Loa Loa (eye worm) hypothetical protein 0.0105 0.0913 0.2037
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0076 0.0612 0.0602
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0135
Loa Loa (eye worm) hypothetical protein 0.045 0.4466 1
Onchocerca volvulus 0.0028 0.0115 0.0114
Onchocerca volvulus 0.045 0.4466 1
Onchocerca volvulus 0.0076 0.0612 0.1243
Schistosoma mansoni hypothetical protein 0.004 0.0236 0.0506
Echinococcus granulosus expressed conserved protein 0.009 0.0755 0.1899
Onchocerca volvulus 0.0105 0.0913 0.1928
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0047 0.0083
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0548 0.0504
Brugia malayi CXXC zinc finger family protein 0.0028 0.0115 0.0235
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0548 0.0539
Brugia malayi PHD-finger family protein 0.0032 0.0156 0.0327
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.005 0.5
Schistosoma mansoni hypothetical protein 0.004 0.0236 0.0506
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0065 0.0123
Brugia malayi PAN domain containing protein 0.0105 0.0913 0.2027
Echinococcus granulosus cpg binding protein 0.0032 0.0155 0.037
Loa Loa (eye worm) hypothetical protein 0.0076 0.0612 0.1361
Loa Loa (eye worm) hypothetical protein 0.0041 0.0251 0.0552
Loa Loa (eye worm) hypothetical protein 0.0076 0.0612 0.1361
Trypanosoma cruzi hypothetical protein, conserved 0.0219 0.2083 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0815 0.1807
Schistosoma mansoni hypothetical protein 0.0076 0.0612 0.1351
Echinococcus multilocularis chromobox protein 1 0.0085 0.0701 0.0691
Schistosoma mansoni zinc finger protein 0.0019 0.0019 0.0019
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0035 0.05
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0047 0.0083
Loa Loa (eye worm) hypothetical protein 0.0105 0.0913 0.2037
Toxoplasma gondii PAN/Apple domain-containing protein 0.0105 0.0913 0.0873
Toxoplasma gondii microneme protein MIC17B 0.0105 0.0913 0.0873
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0041 0.0078
Loa Loa (eye worm) hypothetical protein 0.0058 0.0425 0.0943
Toxoplasma gondii subtilisin SUB12 0.0105 0.0913 0.0873
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.005 0.0102
Loa Loa (eye worm) TK/ROR protein kinase 0.0219 0.2083 0.4659
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0425 0.1058
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0044 0.0277 0.0681
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0425 0.0931
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0815 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.037 0.082
Brugia malayi PAN domain containing protein 0.0105 0.0913 0.2027
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0047 0.0037
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0065 0.5
Onchocerca volvulus 0.0105 0.0913 0.1928
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0425 0.0415
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0076 0.0612 0.0602
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0508 0.1269
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0251 0.3581
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.3934 0.3928
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.037 0.0918
Brugia malayi Bromodomain containing protein 0.0093 0.0784 0.1737
Brugia malayi Bromodomain containing protein 0.0047 0.0307 0.0667
Loa Loa (eye worm) hypothetical protein 0.0172 0.1602 0.358
Echinococcus multilocularis muscleblind protein 1 0.0172 0.1602 0.1593
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0354 0.5049
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0354 0.0657
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0065 0.0223
Echinococcus granulosus muscleblind protein 0.0172 0.1602 0.4057
Echinococcus multilocularis muscleblind protein 0.0172 0.1602 0.1593
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0425 0.0415
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.005 0.0153
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0403 0.0357
Brugia malayi Trypsin family protein 0.0076 0.0612 0.1351
Schistosoma mansoni cercarial elastase (S01 family) 0.0076 0.0612 0.1351
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0548 0.1208
Onchocerca volvulus 0.0219 0.2083 0.4586
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0115 0.0248
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.037 0.0808
Onchocerca volvulus 0.0076 0.0612 0.1243
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0086 0.0182
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0035 0.05
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0188 0.0399
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0323 0.0703
Echinococcus multilocularis transmembrane protease serine 3 0.0076 0.0612 0.0602
Loa Loa (eye worm) hypothetical protein 0.0037 0.0211 0.0462
Brugia malayi PAN domain containing protein 0.0105 0.0913 0.2027
Echinococcus granulosus dnaJ subfamily B 0.0398 0.3934 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0548 0.1372
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.07
Onchocerca volvulus 0.0076 0.0612 0.1243
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0065 0.1107
Schistosoma mansoni cpg binding protein 0.0032 0.0155 0.0326
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0188 0.0178
Brugia malayi PAN domain containing protein 0.0105 0.0913 0.2027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0035 0.05
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0065 0.5
Toxoplasma gondii microneme protein, putative 0.0105 0.0913 0.0873
Loa Loa (eye worm) hypothetical protein 0.0105 0.0913 0.2037
Onchocerca volvulus 0.0037 0.0211 0.0332
Brugia malayi PAN domain containing protein 0.0105 0.0913 0.2027
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0126 0.0116
Onchocerca volvulus 0.0105 0.0913 0.1928
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0188 0.0453
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.045 0.4466 1
Onchocerca volvulus 0.0105 0.0913 0.1928
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0035 0.05
Onchocerca volvulus 0.0058 0.0425 0.0819
Loa Loa (eye worm) PAN domain-containing protein 0.0105 0.0913 0.2037
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0425 0.0819
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.005 0.0102
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.005 0.0839
Loa Loa (eye worm) hypothetical protein 0.0086 0.0714 0.159
Brugia malayi mbt repeat family protein 0.0058 0.0425 0.0931
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0354 0.5049
Schistosoma mansoni hypothetical protein 0.0035 0.0188 0.0399
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0065 0.0123
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0126 0.026
Loa Loa (eye worm) hypothetical protein 0.0076 0.0612 0.1361
Echinococcus multilocularis enteropeptidase 0.0076 0.0612 0.0602
Echinococcus multilocularis chromobox protein 1 0.0085 0.0701 0.0691
Toxoplasma gondii PAN domain-containing protein 0.0105 0.0913 0.0873
Brugia malayi PAN domain containing protein 0.0105 0.0913 0.2027
Echinococcus granulosus tumor protein p63 0.0329 0.322 0.818
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0048 0.0098
Onchocerca volvulus 0.0048 0.0323 0.0587
Plasmodium falciparum cysteine repeat modular protein 1 0.0219 0.2083 1
Entamoeba histolytica hypothetical protein 0.0035 0.0188 0.18
Toxoplasma gondii microneme protein MIC4 0.0105 0.0913 0.0873
Loa Loa (eye worm) MBCTL1 0.0066 0.0508 0.1128
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0251 0.0614
Loa Loa (eye worm) hypothetical protein 0.0076 0.0612 0.1361
Schistosoma mansoni hypothetical protein 0.004 0.0236 0.0506
Brugia malayi Heterochromatin protein 1 0.0085 0.0701 0.155
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0076 0.0612 0.1534
Loa Loa (eye worm) hypothetical protein 0.0047 0.0308 0.068
Toxoplasma gondii PAN domain-containing protein 0.0105 0.0913 0.0873
Schistosoma mansoni hypothetical protein 0.0076 0.0612 0.1351
Trichomonas vaginalis chromobox protein, putative 0.0085 0.0701 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.1239 0.1231
Echinococcus multilocularis expressed conserved protein 0.009 0.0755 0.0746
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0076 0.0612 0.1534
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.005 0.0751
Schistosoma mansoni cercarial elastase (S01 family) 0.0076 0.0612 0.1351
Loa Loa (eye worm) hypothetical protein 0.0105 0.0913 0.2037
Brugia malayi Trypsin family protein 0.045 0.4466 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0076 0.0612 0.1351
Schistosoma mansoni cercarial elastase (S01 family) 0.0076 0.0612 0.1351
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0076 0.0612 0.1351
Schistosoma mansoni hypothetical protein 0.004 0.0236 0.0506
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0425 0.1058
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0233 0.223 0.5658
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0592 0.1483
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0035 0.05
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0508 0.0498
Onchocerca volvulus 0.0076 0.0612 0.1243
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0041 0.0068
Onchocerca volvulus 0.0105 0.0913 0.1928
Loa Loa (eye worm) heterochromatin protein 1 0.0085 0.0701 0.156
Toxoplasma gondii microneme protein MIC17C 0.0105 0.0913 0.0873
Schistosoma mansoni hypothetical protein 0.0219 0.2083 0.4652
Loa Loa (eye worm) hypothetical protein 0.005 0.0338 0.0747
Brugia malayi Trypsin family protein 0.0076 0.0612 0.1351
Brugia malayi Kringle domain containing protein 0.0219 0.2083 0.4652
Loa Loa (eye worm) hypothetical protein 0.0096 0.0815 0.1817
Toxoplasma gondii PAN domain-containing protein 0.0105 0.0913 0.0873
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.005 0.0153
Onchocerca volvulus 0.0105 0.0913 0.1928
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0005 0.0068
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0251 0.0552
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0065 0.0991
Echinococcus granulosus chromobox protein 1 0.0085 0.0701 0.176
Onchocerca volvulus 0.0105 0.0913 0.1928
Schistosoma mansoni chromobox protein 0.0085 0.0701 0.155
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0126 0.0295
Echinococcus granulosus transmembrane protease serine 3 0.0076 0.0612 0.1534
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.005 0.004
Brugia malayi chromobox protein homolog 3 0.0047 0.0317 0.0688
Loa Loa (eye worm) CHromoDomain protein family member 0.0018 0.001 0.0013
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.005 0.5
Brugia malayi PAN domain containing protein 0.0105 0.0913 0.2027
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0065 0.0991
Brugia malayi hypothetical protein 0.0076 0.0612 0.1351
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.005 0.0716
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0508 0.1117
Loa Loa (eye worm) PAN domain-containing protein 0.0105 0.0913 0.2037
Schistosoma mansoni hypothetical protein 0.0025 0.0086 0.0169
Schistosoma mansoni cercarial elastase (S01 family) 0.0076 0.0612 0.1351
Toxoplasma gondii hypothetical protein 0.0105 0.0913 0.0873
Schistosoma mansoni cercarial elastase (S01 family) 0.0076 0.0612 0.1351
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0135
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0076 0.0612 0.1351
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0065 0.0991
Toxoplasma gondii PAN domain-containing protein 0.098 0.9939 1
Schistosoma mansoni chromobox protein 0.0085 0.0701 0.155
Schistosoma mansoni cercarial elastase (S01 family) 0.0076 0.0612 0.1351
Onchocerca volvulus 0.0374 0.3681 0.8216
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.005 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0174 0.2477
Brugia malayi PAN domain containing protein 0.0105 0.0913 0.2027
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.005 0.022
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.005 0.5
Schistosoma mansoni hypothetical protein 0.0019 0.0019 0.0019
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0508 0.1117
Entamoeba histolytica hypothetical protein 0.0035 0.0188 0.18
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.005 0.022
Schistosoma mansoni bromodomain containing protein 0.0079 0.0637 0.1407
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0317 0.0572
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.037 0.0361
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0251 0.0614
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0035 0.05
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0044 0.0277 0.0268
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0065 0.019
Brugia malayi Trypsin family protein 0.0076 0.0612 0.1351
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0005 0.5
Onchocerca volvulus 0.0105 0.0913 0.1928
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0041 0.0068
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0425 0.0943
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.037 0.0808
Loa Loa (eye worm) hypothetical protein 0.0053 0.0378 0.0837
Onchocerca volvulus 0.0105 0.0913 0.1928
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0548 0.1208
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0065 0.0991
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.045 0.4466 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0065 0.0991
Echinococcus granulosus chromobox protein 1 0.0085 0.0701 0.176
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0035 0.05
Schistosoma mansoni hypothetical protein 0.0398 0.3934 0.8806
Schistosoma mansoni patched 1 0.0041 0.0251 0.054
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0047 0.0094
Echinococcus granulosus glycoprotein Antigen 5 0.0076 0.0612 0.1534
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0592 0.0583
Echinococcus multilocularis glycoprotein Antigen 5 0.0076 0.0612 0.0602
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0508 0.1269
Echinococcus multilocularis zinc finger protein 0.0025 0.0089 0.0079
Schistosoma mansoni hypothetical protein 0.0357 0.351 0.7854
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.005 0.0153
Brugia malayi Protein kinase domain containing protein 0.0219 0.2083 0.4652
Loa Loa (eye worm) hypothetical protein 0.005 0.0346 0.0766
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0425 0.0931
Loa Loa (eye worm) hypothetical protein 0.0219 0.2083 0.4659
Brugia malayi CHE-14 protein 0.0041 0.0251 0.054
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0831 0.1841
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0065 0.0991
Echinococcus granulosus zinc finger protein 0.0025 0.0089 0.02
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0105 0.0913 0.0873
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0548 0.8953
Loa Loa (eye worm) hypothetical protein 0.0172 0.1602 0.358
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0005 0.0068
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0041 0.0031
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0076 0.0612 0.1351
Loa Loa (eye worm) PAN domain-containing protein 0.0105 0.0913 0.2037
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0815 0.2052
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0095
Echinococcus multilocularis tumor protein p63 0.0329 0.322 0.3213
Schistosoma mansoni cercarial elastase (S01 family) 0.0076 0.0612 0.1351
Loa Loa (eye worm) hypothetical protein 0.0066 0.0508 0.1128
Brugia malayi PAN domain containing protein 0.0105 0.0913 0.2027
Trichomonas vaginalis chromobox protein, putative 0.0085 0.0701 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0438 0.0961
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0174 0.2477
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0251 0.0241
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0035 0.05
Toxoplasma gondii kringle domain-containing protein 0.0219 0.2083 0.2056

Activities

Activity type Activity value Assay description Source Reference
I50 (binding) = 10 uM Inhibition of Peak I phosphodiesterase from pig coronary arteries ChEMBL. 6276544
I50 (binding) = 36 uM Inhibition of pig coronary artery cAMP-specific phosphodiesterase ChEMBL. 6276544

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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