Detailed information for compound 309005

Basic information

Technical information
  • TDR Targets ID: 309005
  • Name: N,N-diethyl-N'-(6-methoxy-4-methylquinolin-8- yl)heptane-1,7-diamine
  • MW: 357.533 | Formula: C22H35N3O
  • H donors: 1 H acceptors: 1 LogP: 5.25 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCCCCCCNc1cc(OC)cc2c1nccc2C)CC
  • InChi: 1S/C22H35N3O/c1-5-25(6-2)15-11-9-7-8-10-13-23-21-17-19(26-4)16-20-18(3)12-14-24-22(20)21/h12,14,16-17,23H,5-11,13,15H2,1-4H3
  • InChiKey: ZFEGQNGGNPZFFS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N,N-diethyl-N'-(6-methoxy-4-methyl-8-quinolyl)heptane-1,7-diamine
  • N,N-diethyl-N'-(6-methoxy-4-methyl-quinolin-8-yl)heptane-1,7-diamine
  • diethyl-[7-[(6-methoxy-4-methyl-8-quinolyl)amino]heptyl]amine
  • Diethyl{7-[(6-methoxy-4-methyl(8-quinolyl))amino]heptyl}amine
  • AIDS-008680
  • AIDS008680
  • Diethyl(7-((6-methoxy-4-methyl(8-quinolyl))amino)heptyl)amine
  • NSC 305839

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0024 0.0011 0.0011
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0024 0.0011 0.0008
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0076 0.017 0.0389
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.142 0.4288 1
Brugia malayi hypothetical protein 0.0024 0.0011 0.0008
Onchocerca volvulus 0.0024 0.0011 0.0004
Brugia malayi hypothetical protein 0.0024 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Toxoplasma gondii ion channel protein 0.0023 0.0007 0.0148
Onchocerca volvulus Glucosylceramidase homolog 0.0195 0.0534 0.0527
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0024 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Plasmodium falciparum potassium channel 0.0023 0.0007 0.022
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0024 0.0011 0.0011
Onchocerca volvulus Peroxidase homolog 0.0029 0.0025 0.0017
Entamoeba histolytica glycogen phosphorylase, putative 0.3285 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0261 0.0735 0.0732
Onchocerca volvulus 0.0024 0.0011 0.0004
Entamoeba histolytica hypothetical protein 0.0036 0.0047 0.0044
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0039 0.1267
Brugia malayi Dopamine receptor protein 2 0.0024 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0023 0.0007 0.0004
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0039 0.0036
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0024 0.0011 0.0008
Schistosoma mansoni opsin-like receptor 0.0024 0.0011 0.0011
Onchocerca volvulus 0.0024 0.0011 0.0004
Leishmania major hypothetical protein, conserved 0.0023 0.0007 0.0006
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0281 0.0799 0.0799
Schistosoma mansoni hypothetical protein 0.0023 0.0007 0.0007
Trichomonas vaginalis glycogen phosphorylase, putative 0.3285 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0011 0.0011
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0024 0.0011 0.0011
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0023 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0029 0.0025 0.0021
Mycobacterium tuberculosis Hypothetical protein 0.0023 0.0007 0.0009
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0074 0.0163 0.0372
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0058 0.0115 0.0115
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0066 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0061 0.0124 0.0283
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0007 0.0007
Leishmania major mitochondrial structure specific endonuclease I (SSE-1), putative 0.0039 0.0056 0.0079
Onchocerca volvulus 0.0091 0.0215 0.0207
Onchocerca volvulus Chorion peroxidase homolog 0.0029 0.0025 0.0017
Brugia malayi Methyltransferase-like protein 4 0.0023 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Echinococcus multilocularis twik family of potassium channels 0.0023 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0079 0.018 0.0177
Onchocerca volvulus 0.0024 0.0011 0.0004
Schistosoma mansoni voltage-gated cation channel 0.0281 0.0799 0.0799
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0081 0.0184 0.6337
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0038 0.0055 0.1826
Loa Loa (eye worm) glycogen phosphorylase 0.3285 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0853 0.2548 0.2548
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0031 0.0031 0.0065
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0024 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Entamoeba histolytica hypothetical protein 0.0036 0.0047 0.0044
Loa Loa (eye worm) melatonin receptor type 1A 0.0024 0.0011 0.0008
Echinococcus granulosus fmrfamide receptor 0.0024 0.0011 0.0011
Schistosoma mansoni sodium/chloride dependent transporter 0.0091 0.0215 0.0215
Brugia malayi Tachykinin-like peptides receptor 99D 0.0024 0.0011 0.0008
Trypanosoma brucei calcium-activated potassium channel, putative 0.0023 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0039 0.0036
Onchocerca volvulus 0.0029 0.0025 0.0017
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0024 0.0011 0.0008
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0076 0.017 0.0389
Schistosoma mansoni opsin-like receptor 0.0024 0.0011 0.0011
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0063 0.0131 0.4398
Toxoplasma gondii hypothetical protein 0.01 0.0243 0.851
Onchocerca volvulus Neuropeptide F receptor homolog 0.0024 0.0011 0.0004
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0047 0.0047
Echinococcus granulosus peroxidasin 0.0029 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.01 0.0243 0.024
Loa Loa (eye worm) hypothetical protein 0.0046 0.0078 0.0074
Brugia malayi follicle stimulating hormone receptor 0.0024 0.0011 0.0008
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0025 0.0021
Schistosoma mansoni neuropeptide receptor 0.0024 0.0011 0.0011
Onchocerca volvulus 0.0024 0.0011 0.0004
Plasmodium falciparum pyruvate kinase 0.0033 0.0039 0.1881
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0062 0.0127 0.029
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0066 0.0139 0.0317
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0011 0.0011
Loa Loa (eye worm) animal heme peroxidase 0.0029 0.0025 0.0021
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.2186 0.6633 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0011 0.0011
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0039 0.0056 0.0079
Echinococcus multilocularis mitogen activated protein kinase 11 0.2186 0.6633 0.6633
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Brugia malayi hypothetical protein 0.0024 0.0011 0.0008
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0023 0.0007 0.0004
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0023 0.0007 0.0004
Toxoplasma gondii RNA-directed DNA polymerase 0.0084 0.0193 0.6737
Brugia malayi hypothetical protein 0.0024 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Schistosoma mansoni eyes absent homolog 0.0079 0.018 0.018
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0023 0.0007 0.0007
Leishmania major hypothetical protein, conserved 0.0023 0.0007 0.0006
Echinococcus granulosus mitogen activated protein kinase 11 0.2186 0.6633 0.6633
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Schistosoma mansoni pyruvate kinase 0.0033 0.0039 0.0039
Toxoplasma gondii type I fatty acid synthase, putative 0.0081 0.0184 0.6431
Loa Loa (eye worm) TYRA-2 protein 0.0024 0.0011 0.0008
Brugia malayi hypothetical protein 0.0024 0.0011 0.0008
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0023 0.0007 0.0004
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0076 0.017 0.581
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0039 0.0036
Loa Loa (eye worm) acyl carrier protein 0.0035 0.0044 0.0041
Echinococcus granulosus twik family of potassium channels 0.0023 0.0007 0.0007
Brugia malayi hypothetical protein 0.0024 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Mycobacterium ulcerans thioesterase TesA 0.0063 0.0131 0.0298
Echinococcus granulosus calcium activated potassium channel variant 0.0023 0.0007 0.0007
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0011 0.0011
Echinococcus granulosus glycogen phosphorylase 0.3285 1 1
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0043 0.0069 0.0154
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0023 0.0007 0.0006
Echinococcus multilocularis Glycosyl transferase, family 35 0.3285 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Onchocerca volvulus Peroxidase homolog 0.0029 0.0025 0.0017
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0023 0.0007 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0011 0.0011
Giardia lamblia Glycogen phosphorylase 0.3285 1 1
Entamoeba histolytica glycogen phosphorylase, putative 0.142 0.4288 0.4286
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0007 0.0004
Schistosoma mansoni histamine h1 receptor 0.0024 0.0011 0.0011
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0114 0.0285 0.0658
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0024 0.0011 0.0011
Onchocerca volvulus 0.0024 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0039 0.0083
Mycobacterium ulcerans polyketide synthase 0.0081 0.0184 0.0423
Giardia lamblia Telomerase catalytic subunit 0.0084 0.0193 0.019
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0023 0.0007 0.0004
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0044 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Echinococcus multilocularis G protein coupled receptor 139 0.0024 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Plasmodium falciparum 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0039 0.0056 0.2774
Mycobacterium ulcerans 5'-3' exonuclease 0.0039 0.0056 0.0123
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0039 0.0036
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0011 0.0011
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0071 0.0155 0.0151
Loa Loa (eye worm) hypothetical protein 0.0128 0.0328 0.0325
Toxoplasma gondii transporter, cation channel family protein 0.0114 0.0285 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0261 0.0735 0.0735
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0302 0.0299
Trichomonas vaginalis glucosylceramidase, putative 0.0297 0.0847 0.0844
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0261 0.0735 0.0735
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0023 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0033 0.0039 0.0036
Echinococcus multilocularis GPCR, family 2 0.0058 0.0115 0.0115
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0306 0.0874 0.0868
Echinococcus multilocularis twik family of potassium channels 0.0023 0.0007 0.0007
Brugia malayi Blistered cuticle protein 3 0.0029 0.0025 0.0021
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0039 0.0054
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0011 0.0011
Toxoplasma gondii LsmAD domain-containing protein 0.0046 0.0078 0.2643
Brugia malayi putative neuropeptide receptor 0.0024 0.0011 0.0008
Onchocerca volvulus Dual oxidase homolog 0.0029 0.0025 0.0017
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0261 0.0735 0.0735
Schistosoma mansoni neuropeptide receptor 0.0024 0.0011 0.0011
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0011 0.0011
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0011 0.0011
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0011 0.0011
Echinococcus multilocularis allatostatin A receptor 0.0024 0.0011 0.0011
Treponema pallidum sodium- and chloride- dependent transporter 0.0091 0.0215 1
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0039 0.1881
Echinococcus granulosus potassium channel subfamily K 8 0.0023 0.0007 0.0007
Schistosoma mansoni peroxidasin 0.0029 0.0025 0.0025
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0039 0.0054
Treponema pallidum DNA polymerase I (polA) 0.0055 0.0104 0.4781
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0024 0.0011 0.0011
Onchocerca volvulus 0.0024 0.0011 0.0004
Echinococcus granulosus neuropeptide s receptor 0.0024 0.0011 0.0011
Schistosoma mansoni pyruvate kinase 0.0033 0.0039 0.0039
Echinococcus granulosus potassium channel subfamily K 8 0.0023 0.0007 0.0007
Schistosoma mansoni calcium-activated potassium channel 0.0023 0.0007 0.0007
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0091 0.0215 0.0212
Brugia malayi hypothetical protein 0.0024 0.0011 0.0008
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0297 0.0847 0.0844
Loa Loa (eye worm) animal heme peroxidase 0.0029 0.0025 0.0021
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0029 0.0025 0.0021
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0039 0.0054
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0011 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0011 0.0011
Toxoplasma gondii ion channel protein 0.0023 0.0007 0.0148
Echinococcus multilocularis sex peptide receptor 0.0024 0.0011 0.0011
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0011 0.0011
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0076 0.017 0.0389
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0007 0.0007
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0024 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Brugia malayi Melatonin receptor type 1A 0.0024 0.0011 0.0008
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0024 0.0011 0.0011
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0023 0.0008 0.0012
Echinococcus granulosus g protein coupled receptor 0.0024 0.0011 0.0011
Entamoeba histolytica glycogen phosphorylase, putative 0.142 0.4288 0.4286
Loa Loa (eye worm) TWK-7 protein 0.0023 0.0007 0.0004
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0023 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Schistosoma mansoni ap endonuclease 0.0022 0.0003 0.0003
Onchocerca volvulus 0.0024 0.0011 0.0004
Schistosoma mansoni biogenic amine receptor 0.0024 0.0011 0.0011
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0081 0.0184 0.0423
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0011 0.0011
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0011 0.0011
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.0007 0.0004
Brugia malayi neuropeptide F receptor 0.0024 0.0011 0.0008
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0261 0.0735 0.0732
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Echinococcus granulosus pyruvate kinase 0.0033 0.0039 0.0039
Plasmodium falciparum telomerase reverse transcriptase 0.0084 0.0193 1
Leishmania major pyruvate kinase 0.0033 0.0039 0.0054
Brugia malayi sulfakinin receptor protein 0.0024 0.0011 0.0008
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0144 0.0379 0.0567
Onchocerca volvulus Glycogen phosphorylase homolog 0.3285 1 1
Loa Loa (eye worm) solute carrier family 6 member 4 0.0091 0.0215 0.0212
Plasmodium vivax potassium channel, putative 0.0023 0.0007 0.022
Trichomonas vaginalis glucosylceramidase, putative 0.0297 0.0847 0.0844
Echinococcus granulosus g protein coupled receptor 0.0024 0.0011 0.0011
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0024 0.0011 0.0011
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0011 0.0008
Echinococcus multilocularis mitogen activated protein kinase 11 0.2186 0.6633 0.6633
Trypanosoma cruzi PAB1-binding protein , putative 0.0046 0.0078 0.0112
Echinococcus granulosus peptide allatostatin:somatostatin 0.0024 0.0011 0.0011
Mycobacterium ulcerans ion transport protein 0.0023 0.0007 0.001
Echinococcus granulosus somatostatin receptor 0.0024 0.0011 0.0011
Schistosoma mansoni sodium/chloride dependent transporter 0.0026 0.0016 0.0016
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0007 0.0007
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0081 0.0184 0.0423
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0084 0.0193 0.0286
Trypanosoma brucei mitochondrial structure specific endonuclease I (SSE-1), putative 0.0039 0.0056 0.0079
Echinococcus granulosus orexin receptor type 2 0.0024 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Mycobacterium ulcerans polyketide synthase 0.0076 0.017 0.0389
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0139 0.0139
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0011 0.0011
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0071 0.0155 0.0353
Schistosoma mansoni hypothetical protein 0.0024 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0058 0.0115 0.0112
Schistosoma mansoni amine GPCR 0.0024 0.0011 0.0011
Echinococcus multilocularis serotonin receptor 0.0024 0.0011 0.0011
Onchocerca volvulus 0.0024 0.0011 0.0004
Chlamydia trachomatis DNA polymerase I 0.0055 0.0104 0.0066
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0039 0.0036
Schistosoma mansoni hypothetical protein 0.0024 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.01 0.0243 0.024
Mycobacterium ulcerans polyketide synthase MbtD 0.0023 0.0008 0.0012
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0007 0.0007
Brugia malayi larval opioid receptor 0.0024 0.0011 0.0008
Brugia malayi Serotonin receptor 0.0024 0.0011 0.0008
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0011 0.0011
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0025 0.0021
Trypanosoma cruzi ion transport protein, putative 0.0023 0.0007 0.0006
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.0007 0.0004
Onchocerca volvulus 0.0071 0.0155 0.0147
Echinococcus multilocularis neuropeptide FF receptor 2 0.0024 0.0011 0.0011
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0011 0.0011
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0011 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0297 0.0847 0.0844
Brugia malayi G protein-coupled receptor 0.0024 0.0011 0.0008
Brugia malayi hypothetical protein 0.003 0.0028 0.0025
Onchocerca volvulus 0.0132 0.0342 0.0335
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Echinococcus granulosus tachykinin peptides receptor 99D 0.0024 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0058 0.0115 0.0115
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0076 0.017 0.0389
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Echinococcus granulosus serotonin transporter 0.0091 0.0215 0.0215
Trichomonas vaginalis glycogen phosphorylase, putative 0.3285 1 1
Echinococcus granulosus sex peptide receptor 0.0024 0.0011 0.0011
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0011 0.0011
Echinococcus granulosus hypothetical protein 0.0024 0.0011 0.0011
Loa Loa (eye worm) animal heme peroxidase 0.0029 0.0025 0.0021
Schistosoma mansoni hypothetical protein 0.0126 0.0322 0.0322
Brugia malayi P38 map kinase family protein 2 0.2186 0.6633 0.6632
Trichomonas vaginalis glucosylceramidase, putative 0.0297 0.0847 0.0844
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0114 0.0285 0.0282
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0011 0.0008
Echinococcus granulosus small conductance calcium activated potassium 0.0023 0.0007 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0011 0.0011
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0023 0.0007 0.001
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0011 0.0011
Onchocerca volvulus 0.0029 0.0025 0.0017
Brugia malayi Latrophilin receptor protein 2 0.0058 0.0115 0.0112
Loa Loa (eye worm) hypothetical protein 0.0079 0.018 0.0177
Brugia malayi hypothetical protein 0.0023 0.0007 0.0004
Plasmodium vivax 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0039 0.0056 0.2774
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Plasmodium vivax potassium channel, putative 0.0023 0.0007 0.022
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0039 0.0032
Loa Loa (eye worm) TWK-28 protein 0.0023 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Brugia malayi RE15519p 0.0024 0.0011 0.0008
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0023 0.0007 0.0007
Mycobacterium tuberculosis Probable thioesterase TesA 0.0063 0.0131 0.0298
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0023 0.0007 0.0004
Entamoeba histolytica hypothetical protein 0.0036 0.0047 0.0044
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0023 0.0007 0.0006
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0011 0.0011
Echinococcus multilocularis potassium channel subfamily K 0.0023 0.0007 0.0007
Brugia malayi hypothetical protein 0.0024 0.0011 0.0008
Leishmania major hypothetical protein, conserved 0.0023 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.2186 0.6633 1
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0011 0.0011
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0025 0.0021
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0155 0.0151
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Schistosoma mansoni hypothetical protein 0.0058 0.0115 0.0115
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0058 0.0115 0.0115
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0007 0.0007
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0023 0.0007 0.0004
Echinococcus granulosus 7TM GPCR rhodopsin 0.0024 0.0011 0.0011
Trypanosoma cruzi ion transport protein, putative 0.0023 0.0007 0.0006
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0011 0.0011
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0302 0.0299
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0024 0.0011 0.0008
Schistosoma mansoni neuropeptide receptor 0.0024 0.0011 0.0011
Loa Loa (eye worm) animal heme peroxidase 0.0029 0.0025 0.0021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0011 0.0011
Echinococcus multilocularis dro:myosuppressin receptor 0.0024 0.0011 0.0011
Echinococcus granulosus g protein coupled receptor 0.0024 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Echinococcus multilocularis neuropeptide receptor A26 0.0024 0.0011 0.0011
Schistosoma mansoni calcium-activated potassium channel 0.0023 0.0007 0.0007
Echinococcus multilocularis peroxidasin 0.0029 0.0025 0.0025
Echinococcus multilocularis calcium activated potassium channel variant 0.0023 0.0007 0.0007
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0023 0.0007 0.0004
Schistosoma mansoni growth hormone secretagogue receptor 0.0024 0.0011 0.0011
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0024 0.0011 0.0011
Giardia lamblia Pyruvate kinase 0.0033 0.0039 0.0036
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0023 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Echinococcus multilocularis orexin receptor type 2 0.0024 0.0011 0.0011
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0023 0.0007 0.0006
Onchocerca volvulus 0.0029 0.0025 0.0017
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0126 0.0322 0.0319
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Brugia malayi ORL1-like opioid receptor 0.0024 0.0011 0.0008
Trypanosoma brucei PAB1-binding protein , putative 0.0046 0.0078 0.0112
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0281 0.0799 0.0799
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0114 0.0285 0.0658
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0024 0.0011 0.0008
Schistosoma mansoni amine GPCR 0.0024 0.0011 0.0011
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0011 0.0011
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0025 0.0021
Echinococcus multilocularis potassium channel subfamily K 8 0.0023 0.0007 0.0007
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0081 0.0184 0.0423
Mycobacterium tuberculosis Probable 5'-3' exonuclease 0.0039 0.0056 0.0123
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0058 0.0115 0.0115
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0024 0.0011 0.0011
Echinococcus multilocularis mitogen activated protein kinase 14 0.2186 0.6633 0.6633
Plasmodium falciparum ataxin-2 like protein, putative 0.0046 0.0078 0.3923
Brugia malayi Telomerase reverse transcriptase 0.0222 0.0618 0.0615
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.0534 0.0531
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0139 0.0317
Echinococcus granulosus potassium channel subfamily K 0.0023 0.0007 0.0007
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0024 0.0011 0.0008
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0011 0.0011
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0081 0.0184 0.6337
Brugia malayi MH2 domain containing protein 0.0119 0.0302 0.0299
Loa Loa (eye worm) hypothetical protein 0.0029 0.0025 0.0021
Loa Loa (eye worm) hypothetical protein 0.0029 0.0025 0.0021
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0281 0.0799 0.0799
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Onchocerca volvulus 0.0024 0.0011 0.0004
Schistosoma mansoni myosin xvIII 0.0024 0.0011 0.0011
Echinococcus granulosus pyruvate kinase 0.0033 0.0039 0.0039
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0024 0.0011 0.0008
Chlamydia trachomatis glycogen phosphorylase 0.3285 1 1
Brugia malayi Dopamine receptor 0.0024 0.0011 0.0008
Schistosoma mansoni hypothetical protein 0.0036 0.0047 0.0047
Echinococcus granulosus mitogen activated protein kinase 14 0.2186 0.6633 0.6633
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0011 0.0011
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0039 0.0083
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Mycobacterium ulcerans Type I modular polyketide synthase 0.0076 0.017 0.0389
Echinococcus multilocularis voltage dependent calcium channel 0.0281 0.0799 0.0799
Schistosoma mansoni methyltransferase-related 0.0023 0.0007 0.0007
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0024 0.0011 0.0011
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0024 0.0011 0.0011
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0007 0.0007
Mycobacterium ulcerans thioesterase 0.0063 0.0131 0.0298
Loa Loa (eye worm) hypothetical protein 0.0029 0.0025 0.0021
Echinococcus granulosus tm gpcr rhodopsin 0.0853 0.2548 0.2548
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0011 0.0011
Echinococcus multilocularis glycogen phosphorylase 0.3285 1 1
Echinococcus granulosus g-protein coupled receptor 0.0024 0.0011 0.0011
Schistosoma mansoni biogenic amine receptor 0.0024 0.0011 0.0011
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0039 0.1048
Brugia malayi latrophilin 2 splice variant baaae 0.0126 0.0322 0.0319
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0281 0.0799 0.0796
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0066 0.0139 0.0136
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0011 0.0011
Loa Loa (eye worm) calcium channel 0.0281 0.0799 0.0796
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.0534 0.0531
Echinococcus granulosus voltage dependent calcium channel 0.0114 0.0285 0.0285
Leishmania major hypothetical protein, conserved 0.0046 0.0078 0.0112
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0011 0.0011
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0076 0.017 0.0167
Schistosoma mansoni neuropeptide receptor 0.0024 0.0011 0.0011
Onchocerca volvulus 0.0024 0.0011 0.0004
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0084 0.0193 0.0286
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0281 0.0799 0.0799
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0024 0.0011 0.0011
Echinococcus multilocularis glycogen phosphorylase 0.3285 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0046 0.0078 0.0112
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0007 0.0006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0261 0.0735 0.0735
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0039 0.0056 0.0079
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0023 0.0007 0.0004
Brugia malayi hypothetical protein 0.0036 0.0047 0.0044
Loa Loa (eye worm) hypothetical protein 0.0029 0.0025 0.0021
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0081 0.0184 0.0423
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0003 0.0003
Brugia malayi putative neuropeptide receptor NPR1 0.0024 0.0011 0.0008
Echinococcus multilocularis small conductance calcium activated potassium 0.0023 0.0007 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0011 0.0011
Mycobacterium ulcerans fatty acid synthase Fas 0.0024 0.001 0.0016
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0008 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0206 0.0566 0.0563
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Echinococcus granulosus voltage dependent calcium channel 0.0281 0.0799 0.0799
Schistosoma mansoni amine GPCR 0.0024 0.0011 0.0011
Echinococcus granulosus twik family of potassium channels 0.0023 0.0007 0.0007
Schistosoma mansoni glycogen phosphorylase 0.3285 1 1
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0144 0.0378 0.0375
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.0534 0.0531
Plasmodium falciparum ataxin-2 like protein, putative 0.0046 0.0078 0.3923
Echinococcus multilocularis neuropeptide s receptor 0.0024 0.0011 0.0011
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0281 0.0799 0.0799
Schistosoma mansoni alpha-1 adrenergic receptor 0.0024 0.0011 0.0011
Echinococcus granulosus G protein coupled receptor 139 0.0024 0.0011 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.0534 0.0531
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Brugia malayi Peroxidasin 0.0029 0.0025 0.0021
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.005 0.0091 0.0205
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0011 0.0011
Echinococcus granulosus neuropeptide FF receptor 2 0.0024 0.0011 0.0011
Echinococcus granulosus GPCR family 2 0.0058 0.0115 0.0115
Mycobacterium ulcerans Type I modular polyketide synthase 0.0076 0.017 0.0389
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Brugia malayi neuropeptide F receptor 0.0024 0.0011 0.0008
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0029 0.0025 0.0021
Brugia malayi G-protein coupled receptor 0.0024 0.0011 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0011 0.0011
Trypanosoma brucei telomerase reverse transcriptase 0.0084 0.0193 0.0286
Brugia malayi hypothetical protein 0.0079 0.018 0.0177
Onchocerca volvulus 0.0024 0.0011 0.0004
Echinococcus granulosus neuropeptide receptor 0.0024 0.0011 0.0011
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0066 0.0139 0.0205
Loa Loa (eye worm) hypothetical protein 0.0029 0.0025 0.0021
Loa Loa (eye worm) uncoordinated protein 58 0.0023 0.0007 0.0004
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0061 0.0124 0.0283
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0011 0.0011
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0007 0.0007
Brugia malayi Calcitonin receptor-like protein seb-1 0.0184 0.05 0.0497
Schistosoma mansoni calcium-activated potassium channel 0.0023 0.0007 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.0534 0.0531
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Brugia malayi AKH receptor 0.0024 0.0011 0.0008
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0281 0.0799 0.0796
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0023 0.0007 0.0004
Echinococcus granulosus allatostatin A receptor 0.0024 0.0011 0.0011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0261 0.0735 0.0735
Trichomonas vaginalis glucosylceramidase, putative 0.0297 0.0847 0.0844
Echinococcus multilocularis serotonin transporter 0.0091 0.0215 0.0215
Mycobacterium tuberculosis Probable DNA polymerase I PolA 0.0055 0.0104 0.0236
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Schistosoma mansoni biogenic amine receptor 0.0024 0.0011 0.0011
Onchocerca volvulus Peroxidasin homolog 0.0029 0.0025 0.0017
Brugia malayi hypothetical protein 0.0024 0.0011 0.0008
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0058 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Echinococcus granulosus dro:myosuppressin receptor 0.0024 0.0011 0.0011
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0011 0.0011
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0139 0.0139
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0011 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0206 0.0566 0.0563
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0023 0.0007 0.0007
Brugia malayi hypothetical protein 0.0046 0.0078 0.0074
Loa Loa (eye worm) hypothetical protein 0.0029 0.0025 0.0021
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Brugia malayi hypothetical protein 0.0023 0.0007 0.0004
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0281 0.0799 0.0799
Echinococcus granulosus alpha 1A adrenergic receptor 0.0024 0.0011 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0297 0.0847 0.0844
Wolbachia endosymbiont of Brugia malayi DNA polymerase I 0.0055 0.0104 1
Onchocerca volvulus Fatty acid synthase homolog 0.0137 0.0357 0.035
Entamoeba histolytica glycogenphosphorylase, putative 0.142 0.4288 0.4286
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0061 0.0124 0.4155
Loa Loa (eye worm) hypothetical protein 0.0029 0.0025 0.0021
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0011 0.0011
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0039 0.0036
Schistosoma mansoni amine GPCR 0.0024 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.0534 0.0531
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0047 0.0047
Echinococcus multilocularis G-protein coupled receptor, putative 0.0024 0.0011 0.0011
Mycobacterium leprae Polyketide synthase Pks13 0.0114 0.0285 1
Echinococcus multilocularis pyruvate kinase 0.0033 0.0039 0.0039
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0011 0.0011
Echinococcus multilocularis sodium channel protein 0.0044 0.0073 0.0073
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0011 0.0011
Onchocerca volvulus Peroxidasin homolog 0.0029 0.0025 0.0017
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0091 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Mycobacterium ulcerans DNA polymerase I 0.0055 0.0104 0.0236
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0024 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0005
Brugia malayi GnHR receptor homolog 0.0024 0.0011 0.0008
Onchocerca volvulus 0.0024 0.0011 0.0004
Schistosoma mansoni peroxidasin 0.0029 0.0025 0.0025
Mycobacterium ulcerans polyketide synthase Pks13 0.0114 0.0285 0.0658
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0023 0.0007 0.0004
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0011 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0261 0.0735 0.0735
Echinococcus multilocularis calcium activated potassium channel 0.0024 0.0011 0.0011
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0055 0.0104 0.0236
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0297 0.0847 0.0844
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0023 0.0007 0.0007
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0081 0.0184 0.0423
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0025 0.0021
Echinococcus granulosus neuropeptide receptor A26 0.0024 0.0011 0.0011
Mycobacterium leprae PROBABLE DNA POLYMERASE I POLA 0.0055 0.0104 0.3427
Loa Loa (eye worm) hypothetical protein 0.0029 0.0025 0.0021
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0011 0.0011
Echinococcus multilocularis serotonin receptor 0.0024 0.0011 0.0011
Leishmania major ion transport protein-like protein 0.0023 0.0007 0.0006
Echinococcus granulosus glycogen phosphorylase 0.3285 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0023 0.0007 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Loa Loa (eye worm) voltage-dependent calcium channel 0.0114 0.0285 0.0282
Schistosoma mansoni hypothetical protein 0.0024 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0011 0.0011
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0039 0.0032
Onchocerca volvulus 0.0024 0.0011 0.0004
Mycobacterium ulcerans Type I modular polyketide synthase 0.0076 0.017 0.0389
Onchocerca volvulus 0.0024 0.0011 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Schistosoma mansoni ap endonuclease 0.0022 0.0003 0.0003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0184 0.05 0.0497
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0011 0.0011
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.005 0.0091 0.2941
Brugia malayi hypothetical protein 0.0024 0.0011 0.0008
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.2186 0.6633 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Onchocerca volvulus 0.0024 0.0011 0.0004
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0281 0.0799 0.0799
Echinococcus multilocularis potassium channel subfamily K 8 0.0023 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0011 0.0011
Loa Loa (eye worm) blistered cuticle protein 3 0.0029 0.0025 0.0021
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0024 0.0011 0.0011
Echinococcus granulosus 7tm_1 domain containing protein 0.0024 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0076 0.017 0.581
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0039 0.0032
Echinococcus multilocularis g-protein coupled receptor 0.0024 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Onchocerca volvulus 0.0024 0.0011 0.0004
Echinococcus multilocularis somatostatin receptor 0.0024 0.0011 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0024 0.0011 0.0011
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.0126 0.0122
Schistosoma mansoni glycogen phosphorylase 0.3285 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0024 0.0011 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.0534 0.0531
Loa Loa (eye worm) hypothetical protein 0.0091 0.0215 0.0212
Loa Loa (eye worm) hypothetical protein 0.0029 0.0025 0.0021
Loa Loa (eye worm) hypothetical protein 0.0091 0.0215 0.0212
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0023 0.0007 0.0004
Schistosoma mansoni hypothetical protein 0.0058 0.0115 0.0115
Echinococcus granulosus serotonin receptor 0.0024 0.0011 0.0011
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0184 0.05 0.0497
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0039 0.0036
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0011 0.0011
Schistosoma mansoni neuropeptide f receptor 76f 0.0024 0.0011 0.0011
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0139 0.0317
Loa Loa (eye worm) fatty acid synthase 0.0075 0.0167 0.0164
Brugia malayi G protein-coupled receptor F59B2.13 0.0024 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0029 0.0025 0.0021
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0011 0.0011
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0039 0.0054
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.081 0.2416 0.2416
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0024 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0058 0.0115 0.0115
Echinococcus granulosus neuropeptide receptor 0.0024 0.0011 0.0011
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0281 0.0799 0.0799
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0184 0.05 0.0497
Leishmania major calcium/potassium channel (CAKC), putative 0.0023 0.0007 0.0006
Brugia malayi Serotonin receptor 0.0024 0.0011 0.0008
Echinococcus multilocularis pyruvate kinase 0.0026 0.0017 0.0017
Mycobacterium ulcerans transmembrane cation transporter 0.0023 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0011 0.0011
Echinococcus multilocularis pyruvate kinase 0.0033 0.0039 0.0039
Mycobacterium leprae Probable polyketide synthase Pks1 0.0081 0.0184 0.6337
Brugia malayi G-protein coupled receptor 0.0024 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Echinococcus granulosus Glycosyl transferase family 35 0.3285 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.0007 0.0004
Giardia lamblia Methyltransferase like 2 0.0023 0.0007 0.0004
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0026 0.0017 0.0032
Loa Loa (eye worm) norepinephrine transporter 0.0091 0.0215 0.0212
Loa Loa (eye worm) latrophilin receptor protein 2 0.0058 0.0115 0.0112
Schistosoma mansoni amine GPCR 0.0356 0.1026 0.1026
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0023 0.0007 0.0004
Brugia malayi hypothetical protein 0.0029 0.0025 0.0021
Schistosoma mansoni adenoreceptor 0.0024 0.0011 0.0011
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0024 0.0011 0.0008
Echinococcus multilocularis mitogen activated protein kinase 14 0.2186 0.6633 0.6633
Entamoeba histolytica glycogen phosphorylase, putative 0.3285 1 1
Plasmodium vivax ataxin-2 like protein, putative 0.0046 0.0078 0.3923
Loa Loa (eye worm) serotonin transporter b 0.0091 0.0215 0.0212
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0049 0.0088 0.3011
Schistosoma mansoni opsin-like receptor 0.0024 0.0011 0.0011
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0023 0.0007 0.0004
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.2186 0.6633 0.6632
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0024 0.0011 0.0008
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0144 0.0379 0.0567
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0261 0.0735 0.0735
Leishmania major potassium channel subunit-like protein 0.0023 0.0007 0.0006
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.142 0.4288 1
Echinococcus multilocularis voltage dependent calcium channel 0.0281 0.0799 0.0799
Loa Loa (eye worm) hypothetical protein 0.0029 0.0025 0.0021
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0024 0.0011 0.0011
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0011 0.0008
Plasmodium falciparum potassium channel 0.0023 0.0007 0.022
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0023 0.0007 0.0006
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0023 0.0007 0.0004
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0058 0.0115 0.0112
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0281 0.0799 0.0799
Loa Loa (eye worm) hypothetical protein 0.0091 0.0215 0.0212
Loa Loa (eye worm) hypothetical protein 0.0043 0.0067 0.0064
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Brugia malayi Dopamine receptor protein 1 0.0024 0.0011 0.0008
Leishmania major pyruvate kinase 0.0033 0.0039 0.0054
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0024 0.0011 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0011 0.0011
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0023 0.0007 0.0004
Echinococcus granulosus calcium activated potassium channel 0.0024 0.0011 0.0011
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0011 0.0011
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0024 0.001 0.0016
Leishmania major telomerase reverse transcriptase, putative 0.0084 0.0193 0.0286
Toxoplasma gondii type I fatty acid synthase, putative 0.0054 0.0103 0.3533
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0074 0.0163 0.0372
Giardia lamblia Hypothetical protein 0.0023 0.0007 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0011 0.0011
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0011 0.0011
Mycobacterium ulcerans polyketide synthase Pks9 0.005 0.0091 0.0205
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.2186 0.6633 1
Plasmodium vivax telomerase reverse transcriptase, putative 0.0084 0.0193 1
Mycobacterium tuberculosis Conserved protein 0.0023 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008
Schistosoma mansoni glycogen phosphorylase 0.142 0.4288 0.4288
Entamoeba histolytica hypothetical protein 0.0036 0.0047 0.0044
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0023 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0008

Activities

Activity type Activity value Assay description Source Reference
G Index (functional) = 96.8 G index = SD90 for meglumine antimoniate / SD90 for the compound ChEMBL. 7411553
Supression (functional) = 6 % Antileishmanial activity against Leishmania donovani in hamsters at a concentration of 52 mg/kg (toxic) ChEMBL. 7411553
Supression (functional) = 73.1 % Antileishmanial activity against Leishmania donovani in hamsters at a concentration of 0.20 mg/kg ChEMBL. 7411553
Supression (functional) = 99.8 % Antileishmanial activity against Leishmania donovani in hamsters at a concentration of 0.81 mg/kg ChEMBL. 7411553
Supression (functional) = 100 % Antileishmanial activity against Leishmania donovani in hamsters at a concentration of 13 mg/kg ChEMBL. 7411553

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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