TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 557.594 | Formula: C31H31N3O7
H donors: 3 H acceptors: 6 LogP: 4.69 Rotable bonds: 15
Rule of 5 violations (Lipinski): 2
SMILES: O=C(N[C@H](C(=O)N[C@H](C(=O)COc1nccc2c1cccc2)CC(=O)O)C(C)C)COc1cccc2c1cccc2
InChi: 1S/C31H31N3O7/c1-19(2)29(34-27(36)18-40-26-13-7-10-20-8-3-5-11-22(20)26)30(39)33-24(16-28(37)38)25(35)17-41-31-23-12-6-4-9-21(23)14-15-32-31/h3-15,19,24,29H,16-18H2,1-2H3,(H,33,39)(H,34,36)(H,37,38)/t24-,29-/m0/s1
InChiKey: SDGSHIPKLHLUGL-OUTSHDOLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Conserved protein	0.0078	0.0415	0.159
Echinococcus multilocularis	neurogenic locus notch protein	0.0093	0.0522	0.0736
Toxoplasma gondii	hypothetical protein	0.0058	0.027	0.1036
Loa Loa (eye worm)	hypothetical protein	0.0288	0.191	0.6177
Onchocerca volvulus	Dual oxidase homolog	0.0288	0.191	0.6113
Schistosoma mansoni	cyclin l	0.0058	0.0274	0.0533
Onchocerca volvulus		0.0093	0.0522	0.1528
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0132	0.0797	0.2295
Mycobacterium ulcerans	DNA-methyltransferase (modification methylase)	0.0052	0.0227	0.0219
Loa Loa (eye worm)	cyclin fold protein 1 variant b	0.0058	0.0274	0.0862
Trypanosoma cruzi	cyclin 9, putative	0.0058	0.0274	0.0197
Echinococcus granulosus	protein jagged 2	0.0093	0.0522	0.1367
Echinococcus granulosus	cyclin dependent kinase 1	0.0132	0.0797	0.2295
Schistosoma mansoni	hypothetical protein	0.017	0.1067	0.3201
Echinococcus multilocularis	cyclin dependent kinase	0.0132	0.0797	0.1235
Trichomonas vaginalis	cyclin B, putative	0.0058	0.0274	0.0093
Echinococcus granulosus	Polycystic kidney disease protein	0.0042	0.016	0.0151
Schistosoma mansoni	notch	0.0093	0.0522	0.1367
Brugia malayi	hypothetical protein	0.0036	0.0115	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0274	0.0862
Loa Loa (eye worm)	hypothetical protein	0.0288	0.191	0.6177
Onchocerca volvulus		0.0288	0.191	0.6113
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.0274	0.0093
Treponema pallidum	methylated-DNA-protein-cysteine S-methyltransferase (dat)	0.0127	0.0764	0.5
Trypanosoma brucei	hypothetical protein, conserved	0.0052	0.0227	0.0207
Giardia lamblia	Cyclin A	0.0241	0.1578	0.4686
Loa Loa (eye worm)	cyclin domain-containing protein	0.0353	0.2371	0.7673
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0058	0.0274	0.1691
Onchocerca volvulus		0.0093	0.0522	0.1528
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0093	0.052	0.1056
Chlamydia trachomatis	methylated-DNA protein-cysteine methyltransferase	0.0127	0.0764	1
Entamoeba histolytica	hypothetical protein	0.0036	0.0115	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0288	0.191	0.6177
Entamoeba histolytica	hypothetical protein	0.0036	0.0115	0.0186
Loa Loa (eye worm)	blistered cuticle protein 3	0.0288	0.191	0.6177
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0055	0.0247	0.0105
Echinococcus multilocularis	Cyclin L1	0.0058	0.0274	0.0287
Trypanosoma brucei	cdc2-related kinase 3	0.0132	0.0797	0.216
Schistosoma mansoni	rab6-interacting	0.0042	0.016	0.0151
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0064	0.0315	0.0341
Brugia malayi	MAP kinase sur-1	0.0055	0.0247	0.0622
Loa Loa (eye worm)	animal heme peroxidase	0.0288	0.191	0.6177
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0353	0.2371	0.7634
Trichomonas vaginalis	cyclins, putative	0.027	0.1783	0.5407
Onchocerca volvulus		0.0093	0.0522	0.1528
Brugia malayi	Blistered cuticle protein 3	0.0288	0.191	0.6113
Brugia malayi	EGF-like domain containing protein	0.0093	0.0522	0.1528
Echinococcus multilocularis	fibropellin Ia	0.0093	0.0522	0.0736
Onchocerca volvulus	Peroxidase homolog	0.0288	0.191	0.6113
Echinococcus multilocularis	protein jagged 2	0.0093	0.0522	0.0736
Echinococcus granulosus	cyclin b3	0.0241	0.1578	0.4922
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0522	0.1667
Echinococcus multilocularis	oligomeric golgi complex subunit 3	0.0058	0.0274	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0522	0.1667
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0058	0.0274	0.0709
Giardia lamblia	Hypothetical protein	0.0241	0.1578	0.4686
Brugia malayi	Calcium binding EGF domain containing protein	0.0093	0.0522	0.1528
Plasmodium vivax	cyclin dependent kinase binding protein, putative	0.0058	0.0274	0.3364
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0423	0.1346
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0398	0.2698	0.8712
Trypanosoma cruzi	O-6 methyl-guanine alkyl transferase, putative	0.0127	0.0764	0.1905
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0055	0.0247	0.0105
Schistosoma mansoni	hypothetical protein	0.0093	0.0522	0.1367
Brugia malayi	hypothetical protein	0.0288	0.191	0.6113
Giardia lamblia	Kinase, CMGC CLK	0.0064	0.0315	0.0239
Schistosoma mansoni	Cyclin fold protein	0.0058	0.0274	0.0533
Onchocerca volvulus		0.0058	0.0274	0.0709
Plasmodium falciparum	cyclin	0.0241	0.1578	1
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0055	0.0247	0.081
Loa Loa (eye worm)	hypothetical protein	0.006	0.0286	0.0904
Trichomonas vaginalis	cyclin D, putative	0.0241	0.1578	0.4686
Loa Loa (eye worm)	notch protein	0.0093	0.0522	0.1667
Brugia malayi	Animal haem peroxidase family protein	0.0288	0.191	0.6113
Echinococcus multilocularis	peroxidasin	0.0288	0.191	0.325
Brugia malayi	Protein kinase domain containing protein	0.0132	0.0797	0.2438
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0465	0.1482
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0142	0.0871	0.2802
Plasmodium vivax	hypothetical protein, conserved	0.0058	0.0274	0.3364
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0093	0.0522	0.0736
Echinococcus multilocularis	protein jagged 1	0.0093	0.0522	0.0736
Echinococcus granulosus	neural cadherin	0.0093	0.0522	0.1367
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0453	0.3088	1
Brugia malayi	Animal haem peroxidase family protein	0.0288	0.191	0.6113
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0522	0.1667
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0058	0.0274	0.0709
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0042	0.016	0.0081
Trichomonas vaginalis	cyclin B, putative	0.0453	0.3088	1
Schistosoma mansoni	cyclins	0.0241	0.1578	0.4922
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0169	0.1065	0.2953
Mycobacterium tuberculosis	Possible transcriptional regulatory protein	0.0078	0.0415	0.159
Echinococcus granulosus	slit 2 protein	0.0093	0.0522	0.1367
Trichomonas vaginalis	CMGC family protein kinase	0.0132	0.0797	0.1937
Loa Loa (eye worm)	animal heme peroxidase	0.0288	0.191	0.6177
Plasmodium vivax	protein kinase Crk2	0.0132	0.0797	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.0059	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0522	0.1667
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0453	0.3088	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0028	0.0059	0.0051
Brugia malayi	EGF-like domain containing protein	0.0093	0.0522	0.1528
Loa Loa (eye worm)	glutaminase 2	0.0324	0.2165	0.7004
Trypanosoma brucei	cyclin dependent kinase-binding protein, putative	0.0058	0.0274	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0288	0.191	0.6177
Trypanosoma cruzi	cdc2-related kinase 3	0.0132	0.0797	0.2021
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0253	0.1661	0.5199
Schistosoma mansoni	notch	0.0093	0.0522	0.1367
Schistosoma mansoni	peroxidasin	0.0288	0.191	0.6039
Echinococcus multilocularis	cyclins	0.0241	0.1578	0.2649
Brugia malayi	hypothetical protein	0.0042	0.016	0.0334
Onchocerca volvulus	Putative cubilin	0.0093	0.0522	0.1528
Schistosoma mansoni	hypothetical protein	0.0093	0.0522	0.1367
Mycobacterium tuberculosis	Methylated-DNA--protein-cysteine methyltransferase Ogt (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA-alkyltra	0.0386	0.261	1
Echinococcus granulosus	cyclin t1	0.0058	0.0274	0.0533
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.0059	0.0051
Schistosoma mansoni	cyclin G2	0.0058	0.0274	0.0533
Trichomonas vaginalis	cyclin B, putative	0.0453	0.3088	1
Schistosoma mansoni	lipoxygenase	0.0177	0.1118	0.3375
Loa Loa (eye worm)	hypothetical protein	0.0288	0.191	0.6177
Onchocerca volvulus	Cyclin L homolog	0.0058	0.0274	0.0709
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0028	0.0059	0.0051
Giardia lamblia	G2/mitotic-specific cyclin B	0.0453	0.3088	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0522	0.1667
Giardia lamblia	Kinase, CMGC CDK	0.0132	0.0797	0.1937
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0028	0.0059	0.0225
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0059	0.0164
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0169	0.1065	0.3321
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0058	0.0274	0.0533
Echinococcus multilocularis	mitogen activated protein kinase	0.0055	0.0247	0.0239
Schistosoma mansoni	peroxidasin	0.0288	0.191	0.6039
Loa Loa (eye worm)	CMGC/CLK protein kinase	0.0064	0.0315	0.0996
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0522	0.1667
Loa Loa (eye worm)	hypothetical protein	0.0288	0.191	0.6177
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0522	0.1667
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0085	0.0465	0.1176
Onchocerca volvulus		0.0288	0.191	0.6113
Echinococcus multilocularis	cyclin B	0.0453	0.3088	0.5382
Onchocerca volvulus		0.0288	0.191	0.6113
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0522	0.1667
Schistosoma mansoni	glutaminase	0.0324	0.2165	0.6896
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0132	0.0797	0.2563
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0132	0.0797	0.2563
Toxoplasma gondii	hypothetical protein	0.0058	0.0274	0.1075
Schistosoma mansoni	DNA (cytosine-5)-methyltransferase	0.0043	0.0166	0.0173
Mycobacterium ulcerans	MarR family transcriptional regulator	0.0078	0.0415	0.0407
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0358	0.2407	0.7669
Brugia malayi	EGF-like domain containing protein	0.0093	0.0522	0.1528
Schistosoma mansoni	serine/threonine protein kinase	0.0093	0.052	0.1362
Loa Loa (eye worm)	hypothetical protein	0.0288	0.191	0.6177
Trichomonas vaginalis	cyclin B3, putative	0.0058	0.0274	0.0093
Onchocerca volvulus	Peroxidasin homolog	0.0288	0.191	0.6113
Brugia malayi	hypothetical protein	0.0042	0.016	0.0334
Mycobacterium tuberculosis	Probable transcriptional regulatory protein	0.0078	0.0415	0.159
Mycobacterium ulcerans	hypothetical protein	0.0078	0.0415	0.0407
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0055	0.0247	0.0622
Brugia malayi	Animal haem peroxidase family protein	0.0288	0.191	0.6113
Schistosoma mansoni	hypothetical protein	0.0113	0.0665	0.185
Echinococcus multilocularis	cyclin B3 1	0.0241	0.1578	0.2649
Trypanosoma brucei	RNA helicase, putative	0.0113	0.0665	0.1707
Brugia malayi	notch-like transmembrane receptor	0.0093	0.0522	0.1528
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0358	0.2407	0.7628
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.0274	0.0093
Mycobacterium ulcerans	transcriptional regulatory protein	0.0078	0.0415	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0453	0.3088	1
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0093	0.052	0.1056
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0142	0.0871	0.1369
Plasmodium vivax	cyclin homologue, putative	0.0058	0.0274	0.3364
Trichomonas vaginalis	cyclins, putative	0.0453	0.3088	1
Mycobacterium leprae	Probable transcriptional regulatory protein (MarR family)	0.0078	0.0415	0.1396
Loa Loa (eye worm)	CYL-1 protein	0.0058	0.0274	0.0862
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0093	0.0522	0.0736
Trichomonas vaginalis	cyclin B, putative	0.0453	0.3088	1
Trichomonas vaginalis	cyclins, putative	0.0453	0.3088	1
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0093	0.052	0.1663
Echinococcus multilocularis	cyclins	0.0241	0.1578	0.2649
Loa Loa (eye worm)	hypothetical protein	0.0288	0.191	0.6177
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0492	0.157
Plasmodium falciparum	cyclin 1	0.0058	0.0274	0.1691
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0055	0.0247	0.0276
Onchocerca volvulus	Peroxidase homolog	0.0288	0.191	0.6113
Toxoplasma gondii	cyclin domain protein, cyclin H family protein	0.0058	0.0274	0.1075
Loa Loa (eye worm)	hypothetical protein	0.0288	0.191	0.6177
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0398	0.2698	0.8733
Loa Loa (eye worm)	hypothetical protein	0.0042	0.016	0.0493
Loa Loa (eye worm)	cyclin domain-containing protein	0.0058	0.0274	0.0862
Onchocerca volvulus	Protein CNPPD1 homolog	0.0058	0.0274	0.0709
Schistosoma mansoni	cell polarity protein	0.0093	0.0522	0.1367
Echinococcus granulosus	mitogen activated protein kinase 3	0.0055	0.0247	0.0444
Schistosoma mansoni	rab6-interacting	0.0042	0.016	0.0151
Echinococcus multilocularis	cyclin	0.0058	0.0274	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0288	0.191	0.6177
Echinococcus multilocularis	neurogenic locus protein delta	0.0093	0.0522	0.0736
Entamoeba histolytica	cyclin family protein	0.0241	0.1578	0.5016
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0522	0.1667
Echinococcus granulosus	cyclins	0.0058	0.0274	0.0533
Echinococcus granulosus	geminin	0.017	0.1067	0.3201
Onchocerca volvulus	Neurogenic locus notch homolog	0.0093	0.0522	0.1528
Trypanosoma brucei	cdc2-related kinase 1	0.0132	0.0797	0.216
Trichomonas vaginalis	cyclin B, putative	0.0058	0.0274	0.0093
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0398	0.2698	0.8688
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0522	0.1667
Onchocerca volvulus	Cyclin L homolog	0.0058	0.0274	0.0709
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0093	0.0522	0.1528
Schistosoma mansoni	serine/threonine protein kinase	0.0055	0.0247	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0212	0.1368	0.4416
Trypanosoma cruzi	cyclin, putative	0.0453	0.3088	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.016	0.0493
Onchocerca volvulus	Slit protein homolog	0.0093	0.0522	0.1528
Onchocerca volvulus		0.0085	0.0465	0.134
Onchocerca volvulus		0.0093	0.0522	0.1528
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.005	0.0217	0.0173
Brugia malayi	Delta serrate ligand family protein	0.0093	0.0522	0.1528
Echinococcus granulosus	cyclins	0.0241	0.1578	0.4922
Giardia lamblia	Cyclin B-like protein	0.0058	0.0274	0.0093
Brugia malayi	Cation transporter family protein	0.0085	0.0465	0.134
Echinococcus granulosus	neurogenic locus notch protein 4	0.0093	0.0522	0.1367
Brugia malayi	Peroxidasin	0.0288	0.191	0.6113
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.0274	0.0093
Toxoplasma gondii	cyclin, N-terminal domain-containing protein	0.0058	0.0274	0.1075
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0142	0.0871	0.2543
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0353	0.2371	0.4084
Plasmodium falciparum	protein serine/threonine kinase-1	0.0064	0.0315	0.1954
Echinococcus granulosus	cdk5 and abl1 enzyme substrate 1	0.0058	0.0274	0.0533
Echinococcus multilocularis	cyclins	0.0241	0.1578	0.2649
Brugia malayi	cyclin fold protein 1 variant b	0.0058	0.0274	0.0709
Echinococcus granulosus	cyclin B	0.0453	0.3088	1
Trichomonas vaginalis	CMGC family protein kinase	0.0064	0.0315	0.0239
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0021	0.0008	0.0031
Giardia lamblia	Hypothetical protein	0.0058	0.0274	0.0093
Mycobacterium tuberculosis	Probable transcriptional regulatory protein	0.0078	0.0415	0.159
Schistosoma mansoni	notch	0.0093	0.0522	0.1367
Onchocerca volvulus	Chorion peroxidase homolog	0.0288	0.191	0.6113
Echinococcus granulosus	protein jagged 2	0.0093	0.0522	0.1367
Entamoeba histolytica	hypothetical protein	0.0058	0.0274	0.0709
Giardia lamblia	Kinase, CMGC CDK	0.0132	0.0797	0.1937
Giardia lamblia	Cyclin fold protein 1, putative	0.0058	0.0274	0.0093
Echinococcus granulosus	cyclin y	0.0058	0.0274	0.0533
Onchocerca volvulus		0.0085	0.0465	0.134
Echinococcus granulosus	Cyclin L1	0.0058	0.0274	0.0533
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0058	0.0274	0.0709
Trichomonas vaginalis	cyclin A, putative	0.0058	0.0274	0.0093
Schistosoma mansoni	hypothetical protein	0.0093	0.0522	0.1367
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0058	0.0274	0.0709
Plasmodium falciparum	protein kinase 5	0.0132	0.0797	0.5026
Onchocerca volvulus		0.0453	0.3088	1
Leishmania major	mitotic cyclin, putative	0.0058	0.0274	0.0709
Echinococcus granulosus	cyclin A3 4	0.0058	0.0274	0.0533
Brugia malayi	Animal haem peroxidase family protein	0.0288	0.191	0.6113
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0453	0.3088	1
Echinococcus multilocularis	cyclin G2	0.0058	0.0274	0.0287
Trichomonas vaginalis	cyclin B3, putative	0.0241	0.1578	0.4686
Echinococcus granulosus	peroxidasin	0.0288	0.191	0.6039
Trichomonas vaginalis	cyclins, putative	0.0058	0.0274	0.0093
Schistosoma mansoni	hypothetical protein	0.0042	0.016	0.0151
Toxoplasma gondii	cyclin 4, putative	0.0058	0.0274	0.1075
Toxoplasma gondii	cyclin dependent kinase binding protein	0.0058	0.0274	0.1075
Trichomonas vaginalis	methylated-DNA--protein-cysteine methyltransferase, putative	0.0127	0.0764	0.1819
Echinococcus granulosus	lipoxygenase domain containing protein	0.0042	0.016	0.0151
Echinococcus multilocularis	neurogenic locus protein delta	0.0093	0.0522	0.0736
Echinococcus granulosus	neurogenic locus notch protein	0.0093	0.0522	0.1367
Echinococcus multilocularis	cyclin b3	0.0241	0.1578	0.2649
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0398	0.2698	0.8688
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0064	0.0315	0.0341
Echinococcus granulosus	lipoxygenase domain containing protein	0.0042	0.016	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0522	0.1667
Trichomonas vaginalis	CMGC family protein kinase	0.0132	0.0797	0.1937
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0453	0.3088	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0028	0.0059	0.0051
Toxoplasma gondii	hypothetical protein	0.0183	0.1163	1
Schistosoma mansoni	polycystin 1-related	0.0042	0.016	0.0151
Echinococcus granulosus	cyclin G2	0.0058	0.0274	0.0533
Entamoeba histolytica	cell division protein kinase 2, putative	0.0132	0.0797	0.2438
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0093	0.0522	0.1367
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0064	0.0315	0.0341
Schistosoma mansoni	notch	0.0093	0.0522	0.1367
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0142	0.0871	0.1369
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0811	0.5639	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0522	0.1667
Echinococcus granulosus	neurogenic locus protein delta	0.0093	0.0522	0.1367
Schistosoma mansoni	serine/threonine protein kinase	0.0064	0.0315	0.0672
Trypanosoma brucei	mitotic cyclin 6	0.0453	0.3088	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0059	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0522	0.1667
Loa Loa (eye worm)	cyclin domain-containing protein	0.0058	0.0274	0.0862
Echinococcus multilocularis	cyclin dependent kinase 5	0.0132	0.0797	0.1235
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0058	0.0274	0.0709
Brugia malayi	EGF-like domain containing protein	0.0093	0.0522	0.1528
Mycobacterium ulcerans	hypothetical protein	0.0188	0.1201	0.1194
Echinococcus multilocularis	geminin	0.017	0.1067	0.1722
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0522	0.1667
Loa Loa (eye worm)	cyclin domain-containing protein	0.0058	0.0274	0.0862
Mycobacterium leprae	PROBABLE METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE OGT (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA	0.0386	0.261	1
Trichomonas vaginalis	cyclins, putative	0.0453	0.3088	1
Echinococcus granulosus	DNA methyltransferase 2, putative	0.0043	0.0166	0.0173
Mycobacterium ulcerans	hypothetical protein	0.0028	0.0059	0.0051
Echinococcus granulosus	cyclins	0.0241	0.1578	0.4922
Trichomonas vaginalis	cyclin B3, putative	0.0058	0.0274	0.0093
Echinococcus multilocularis	cyclin dependent kinase 1	0.0132	0.0797	0.1235
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0253	0.1661	0.2798
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0522	0.1667
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0522	0.1667
Brugia malayi	EGF-like domain containing protein	0.0093	0.0522	0.1528
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0358	0.2407	0.7628
Echinococcus multilocularis	neurogenic locus notch protein	0.0093	0.0522	0.0736
Schistosoma mansoni	septate junction protein	0.0093	0.0522	0.1367
Trichomonas vaginalis	cyclin D, putative	0.0241	0.1578	0.4686
Loa Loa (eye worm)	animal heme peroxidase	0.0288	0.191	0.6177
Echinococcus granulosus	cyclins	0.0241	0.1578	0.4922
Schistosoma mansoni	cyclin B3	0.0353	0.2371	0.7589
Brugia malayi	Animal haem peroxidase family protein	0.0288	0.191	0.6113
Leishmania major	modification methylase-like protein	0.0043	0.0166	0.0356
Entamoeba histolytica	cyclin, putative	0.0241	0.1578	0.5016
Entamoeba histolytica	cyclin C, putative	0.0058	0.0274	0.0709
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0093	0.052	0.1211
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0058	0.0274	0.0709
Brugia malayi	Cadherin domain containing protein	0.0093	0.0522	0.1528
Loa Loa (eye worm)	Notch2	0.0093	0.0522	0.1667
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0059	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0288	0.191	0.6177
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0085	0.0465	0.1176
Trypanosoma brucei	cyclin 9	0.0058	0.0274	0.0367
Schistosoma mansoni	serine/threonine protein kinase	0.0064	0.0315	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0288	0.191	0.6177
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.0274	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0453	0.3088	1
Echinococcus multilocularis	cyclin G2	0.0058	0.0274	0.0287
Echinococcus granulosus	protein jagged 1	0.0093	0.0522	0.1367
Entamoeba histolytica	cyclin, domain containing protein	0.0058	0.0274	0.0709
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0398	0.2698	0.4675
Echinococcus granulosus	cyclin dependent kinase 5	0.0132	0.0797	0.2295
Schistosoma mansoni	cyclin d	0.0058	0.0274	0.0533
Plasmodium vivax	serine/threonine kinase-1, putative	0.0064	0.0315	0.3888
Brugia malayi	Calcium binding EGF domain containing protein	0.0093	0.0522	0.1528
Echinococcus granulosus	cyclin G2	0.0058	0.0274	0.0533
Loa Loa (eye worm)	glutaminase	0.0324	0.2165	0.7004
Trypanosoma brucei	protein kinase, putative	0.0055	0.0247	0.0276
Echinococcus granulosus	cyclin	0.0058	0.0274	0.0533
Loa Loa (eye worm)	hypothetical protein	0.0288	0.191	0.6177
Onchocerca volvulus		0.0042	0.016	0.0334
Schistosoma mansoni	hypothetical protein	0.0093	0.0522	0.1367
Leishmania major	cyclin 9, putative	0.0058	0.0274	0.0709
Echinococcus multilocularis	dual specificity	0.0093	0.052	0.0733
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0522	0.1667
Echinococcus granulosus	hypothetical protein	0.006	0.0286	0.0576
Entamoeba histolytica	protein kinase, putative	0.0093	0.052	0.1523
Brugia malayi	cell division control protein 2 homolog	0.0132	0.0797	0.2438
Leishmania major	protein kinase, putative	0.0064	0.0315	0.0846
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0522	0.1667
Leishmania major	hypothetical protein, conserved	0.0127	0.0764	0.2328
Plasmodium falciparum	cyclin dependent kinase binding protein, putative	0.0058	0.0274	0.1691
Trichomonas vaginalis	cyclin A, putative	0.0453	0.3088	1
Leishmania major	protein kinase, putative	0.0064	0.0315	0.0846
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0465	0.1482
Trypanosoma cruzi	cdc2-related kinase 1	0.0132	0.0797	0.2021
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0169	0.1065	0.3075
Leishmania major	cyclin	0.0453	0.3088	1
Echinococcus multilocularis	notch	0.0093	0.0522	0.0736
Echinococcus granulosus	dual specificity protein kinase clk2	0.0064	0.0315	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0492	0.157
Echinococcus multilocularis	cyclins	0.0241	0.1578	0.2649
Loa Loa (eye worm)	animal heme peroxidase	0.0288	0.191	0.6177
Schistosoma mansoni	cyclin k	0.0058	0.0274	0.0533
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0142	0.0871	0.2682
Echinococcus multilocularis	slit 2 protein	0.0093	0.0522	0.0736
Echinococcus multilocularis		0.006	0.0286	0.031
Echinococcus multilocularis	DNA methyltransferase 2, putative	0.0043	0.0166	0.0093
Leishmania major	mitochondrial DNA polymerase beta	0.0358	0.2407	0.7752
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0093	0.052	0.1523
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.0059	0.0051
Entamoeba histolytica	cell division protein kinase 2, putative	0.0132	0.0797	0.2438
Echinococcus multilocularis	RUN	0.0042	0.016	0.0081
Trichomonas vaginalis	cyclins, putative	0.0241	0.1578	0.4686
Echinococcus granulosus	RUN	0.0042	0.016	0.0151
Schistosoma mansoni	hypothetical protein	0.0093	0.0522	0.1367
Echinococcus granulosus	neurogenic locus notch protein	0.0093	0.0522	0.1367
Brugia malayi	Calcium binding EGF domain containing protein	0.0093	0.0522	0.1528
Echinococcus granulosus	cyclin B3 1	0.0241	0.1578	0.4922
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0028	0.0059	0.0225
Schistosoma mansoni	slit	0.0093	0.0522	0.1367
Schistosoma mansoni	g1/s-specific cyclin C	0.0058	0.0274	0.0533
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0522	0.1667
Echinococcus multilocularis	cyclin y	0.0058	0.0274	0.0287
Brugia malayi	hypothetical protein	0.0058	0.0274	0.0709
Trichomonas vaginalis	conserved hypothetical protein	0.0241	0.1578	0.4686
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0132	0.0797	0.6329
Echinococcus multilocularis	protein jagged 1	0.0093	0.0522	0.0736
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0132	0.0797	0.2563
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0093	0.0522	0.1528
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0055	0.0247	0.0622
Trypanosoma cruzi	cyclin, putative	0.0453	0.3088	1
Brugia malayi	Muscle positioning protein 4	0.0093	0.0522	0.1528
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0769	0.247
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0132	0.0797	0.2438
Brugia malayi	hypothetical protein	0.0058	0.0274	0.0709
Trichomonas vaginalis	cyclin B, putative	0.0241	0.1578	0.4686
Schistosoma mansoni	loxhd1	0.0042	0.016	0.0151
Schistosoma mansoni	hypothetical protein	0.0058	0.0274	0.0533
Brugia malayi	Doublecortin family protein	0.0042	0.016	0.0334
Echinococcus granulosus	delta-like protein 1	0.0093	0.0522	0.1367
Schistosoma mansoni	serine/threonine protein kinase	0.0132	0.0797	0.2295
Echinococcus multilocularis	cyclins	0.0241	0.1578	0.2649
Trichomonas vaginalis	glutaminase, putative	0.0324	0.2165	0.6752
Entamoeba histolytica	hypothetical protein	0.0036	0.0115	0.0186
Loa Loa (eye worm)	doublecortin family protein	0.0042	0.016	0.0493
Trypanosoma brucei	kinetoplastid kinetochore protein 10	0.0064	0.0315	0.0509
Schistosoma mansoni	lipoxygenase	0.0253	0.1661	0.5199
Brugia malayi	Cadherin domain containing protein	0.0093	0.0522	0.1528
Plasmodium falciparum	LCCL domain-containing protein	0.0042	0.016	0.0967
Entamoeba histolytica	hypothetical protein	0.0093	0.052	0.1523
Onchocerca volvulus		0.0085	0.0465	0.134
Echinococcus granulosus	cyclins	0.0241	0.1578	0.4922
Mycobacterium ulcerans	glutaminase	0.0324	0.2165	0.2159
Entamoeba histolytica	cyclin, putative	0.0453	0.3088	1
Echinococcus granulosus	cyclins	0.0241	0.1578	0.4922
Trichomonas vaginalis	cyclins, putative	0.0058	0.0274	0.0093
Schistosoma mansoni	cyclin B	0.0453	0.3088	1
Trypanosoma brucei	cyclin 3	0.0058	0.0274	0.0367
Trypanosoma brucei	mitotic cyclin	0.0058	0.0274	0.0367
Brugia malayi	Protein kinase domain containing protein	0.0093	0.052	0.1523
Echinococcus granulosus	cyclin dependent kinase	0.0132	0.0797	0.2295
Entamoeba histolytica	protein kinase, putative	0.0093	0.052	0.1523
Echinococcus multilocularis	neural cadherin	0.0093	0.0522	0.0736
Trypanosoma cruzi	hypothetical protein, conserved	0.0058	0.0274	0.0197
Schistosoma mansoni	hypothetical protein	0.0058	0.0274	0.0533
Giardia lamblia	High cysteine protein	0.0093	0.0522	0.0966
Echinococcus multilocularis	cyclin dependent kinase 1	0.0132	0.0797	0.1235
Echinococcus multilocularis	cyclin t1	0.0058	0.0274	0.0287
Brugia malayi	GCC2 and GCC3 family protein	0.0093	0.0522	0.1528
Trypanosoma brucei	kinetoplastid kinetochore protein 19	0.0064	0.0315	0.0509
Entamoeba histolytica	DNA (cytosine-5)-methyltransferase, putative	0.0043	0.0166	0.0356
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0132	0.0797	0.2438
Onchocerca volvulus		0.0093	0.0522	0.1528
Entamoeba histolytica	protein kinase domain containing protein	0.0093	0.052	0.1523
Trichomonas vaginalis	cyclins, putative	0.0453	0.3088	1
Mycobacterium leprae	POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY MARR-FAMILY)	0.0078	0.0415	0.1396
Mycobacterium ulcerans	transcriptional regulator	0.0078	0.0415	0.0407
Loa Loa (eye worm)	cyclin domain-containing protein	0.0058	0.0274	0.0862
Loa Loa (eye worm)	cyclin domain-containing protein	0.0058	0.0274	0.0862
Plasmodium falciparum	DNA (cytosine-5)-methyltransferase	0.0043	0.0166	0.1008
Echinococcus multilocularis	Polycystic kidney disease protein	0.0042	0.016	0.0081
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0058	0.0274	0.0709
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0055	0.0247	0.0105
Brugia malayi	Cyclin C	0.0058	0.0274	0.0709
Echinococcus multilocularis	cyclins	0.0241	0.1578	0.2649
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0522	0.1667
Echinococcus multilocularis	dual specificity protein kinase clk2	0.0064	0.0315	0.0362
Echinococcus granulosus	cyclin y	0.0058	0.0274	0.0533
Echinococcus granulosus	protein jagged 1	0.0093	0.0522	0.1367
Echinococcus multilocularis	cyclin y	0.0058	0.0274	0.0287
Mycobacterium ulcerans	transcriptional regulatory protein	0.0078	0.0415	0.0407
Echinococcus multilocularis	cyclin A3 4	0.0058	0.0274	0.0287
Plasmodium vivax	multidomain scavenger receptor, putative	0.0042	0.016	0.1923
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0042	0.016	0.0081
Echinococcus granulosus	fibropellin Ia	0.0093	0.0522	0.1367
Echinococcus granulosus	cyclin k	0.0058	0.0274	0.0533
Trypanosoma cruzi	mitotic cyclin, putative	0.0058	0.0274	0.0197
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0055	0.0247	0.0105
Schistosoma mansoni	laminin gamma-3 chain	0.0093	0.0522	0.1367
Schistosoma mansoni	hypothetical protein	0.0093	0.0522	0.1367
Mycobacterium ulcerans	transcriptional regulator	0.0078	0.0415	0.0407
Brugia malayi	EGF-like domain containing protein	0.0093	0.0522	0.1528
Echinococcus granulosus	oligomeric golgi complex subunit 3	0.0058	0.0274	0.0533
Echinococcus granulosus	notch	0.0093	0.0522	0.1367
Brugia malayi	glutaminase DH11.1	0.0324	0.2165	0.6954
Schistosoma mansoni	hypothetical protein	0.0093	0.0522	0.1367
Schistosoma mansoni	notch	0.0093	0.0522	0.1367
Plasmodium vivax	DNA (cytosine-5)-methyltransferase, putative	0.0043	0.0166	0.2006
Echinococcus multilocularis	cyclins	0.0241	0.1578	0.2649
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0064	0.0315	0.0341
Trichomonas vaginalis	CMGC family protein kinase	0.0132	0.0797	0.1937
Loa Loa (eye worm)	cyclin domain-containing protein	0.0058	0.0274	0.0862
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0061	0.0295	0.0273
Plasmodium vivax	cyclin 4, putative	0.0058	0.0274	0.3364
Echinococcus multilocularis	cyclin k	0.0058	0.0274	0.0287
Entamoeba histolytica	hypothetical protein	0.0036	0.0115	0.0186
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0028	0.0059	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0274	0.0862
Mycobacterium ulcerans	methylated-DNA--protein-cysteine methyltransferase Ogt	0.0386	0.261	0.2604
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	0.0064	0.0315	0.149
Trypanosoma cruzi	mitotic cyclin, putative	0.0058	0.0274	0.0197
Leishmania major	mitotic cyclin, putative	0.0058	0.0274	0.0709
Entamoeba histolytica	cyclin, domain containing protein	0.0058	0.0274	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0288	0.191	0.6177
Trichomonas vaginalis	cyclin D, putative	0.0058	0.0274	0.0093
Giardia lamblia	Hypothetical protein	0.0058	0.0274	0.0093
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0142	0.0871	0.2543
Trypanosoma cruzi	cyclin 6, putative	0.0453	0.3088	1
Brugia malayi	Protein kinase domain containing protein	0.0064	0.0315	0.0846
Echinococcus multilocularis	G1:S specific cyclin D1	0.0058	0.0274	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0522	0.1667
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0188	0.1201	0.4601
Brugia malayi	EGF-like domain containing protein	0.0093	0.0522	0.1528
Schistosoma mansoni	notch	0.0093	0.0522	0.1367
Trichomonas vaginalis	cyclin B, putative	0.0453	0.3088	1
Onchocerca volvulus	Peroxidasin homolog	0.0288	0.191	0.6113
Schistosoma mansoni	cyclin G	0.0058	0.0274	0.0533
Entamoeba histolytica	cyclin family protein	0.0241	0.1578	0.5016
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0353	0.2371	0.7589
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0142	0.0871	0.2543
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0055	0.0247	0.0776
Schistosoma mansoni	hypothetical protein	0.017	0.1067	0.3201
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0522	0.1667
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0055	0.0247	0.0239
Echinococcus granulosus	mitogen activated protein kinase	0.0055	0.0247	0.0444
Mycobacterium ulcerans	transcriptional regulatory protein	0.0078	0.0415	0.0407
Trypanosoma cruzi	O-6 methyl-guanine alkyl transferase, putative	0.0127	0.0764	0.1905
Echinococcus multilocularis	cdk5 and abl1 enzyme substrate 1	0.0058	0.0274	0.0287
Echinococcus granulosus	G1:S specific cyclin D1	0.0058	0.0274	0.0533
Onchocerca volvulus		0.0042	0.016	0.0334
Toxoplasma gondii	EGF family domain-containing protein	0.0093	0.0522	0.3562
Echinococcus granulosus	dual specificity	0.0093	0.052	0.1362
Loa Loa (eye worm)	cyclin C	0.0058	0.0274	0.0862
Mycobacterium tuberculosis	Possible transcriptional regulatory protein (probably MarR-family)	0.0078	0.0415	0.159
Schistosoma mansoni	serine/threonine protein kinase	0.0132	0.0797	0.2295
Trypanosoma cruzi	cdc2-related kinase 3	0.0132	0.0797	0.2021
Trypanosoma cruzi	cdc2-related kinase 1	0.0132	0.0797	0.2021

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 106 uM	Inhibitory concentration for cellular activity in jurkat assay	ChEMBL.	15964758
IC50 (functional)	= 106 uM	Inhibitory concentration for cellular activity in jurkat assay	ChEMBL.	15964758
k3/ki (binding)	= 177 1/m/s	Binding affinity against Caspase-8	ChEMBL.	15964758
k3/ki (binding)	= 177 1/m/s	Binding affinity against Caspase-8	ChEMBL.	15964758
k3/ki (binding)	= 360 1/m/s	Binding affinity against mouse Caspase-1	ChEMBL.	15964758
k3/ki (binding)	= 360 1/m/s	Binding affinity against mouse Caspase-1	ChEMBL.	15964758
k3/ki (binding)	= 462 1/m/s	Binding affinity against Caspase-6	ChEMBL.	15964758
k3/ki (binding)	= 462 1/m/s	Binding affinity against Caspase-6	ChEMBL.	15964758
k3/ki (binding)	= 1307 1/m/s	Binding affinity against Caspase-3	ChEMBL.	15964758
k3/ki (binding)	= 1307 1/m/s	Binding affinity against Caspase-3	ChEMBL.	15964758

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL367207

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 310401