Detailed information for compound 313764

Basic information

Technical information
  • TDR Targets ID: 313764
  • Name: N-(4-chlorophenyl)-N-hydroxycyclohexanecarbox amide
  • MW: 253.725 | Formula: C13H16ClNO2
  • H donors: 1 H acceptors: 2 LogP: 3.5 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: ON(c1ccc(cc1)Cl)C(=O)C1CCCCC1
  • InChi: 1S/C13H16ClNO2/c14-11-6-8-12(9-7-11)15(17)13(16)10-4-2-1-3-5-10/h6-10,17H,1-5H2
  • InChiKey: FXAFVMIOYIOHOW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-chlorophenyl)-N-hydroxy-cyclohexanecarboxamide
  • AIDS226764
  • Cyclohexanecarboxamide, N-(4-chlorophenyl)-N-hydroxy-
  • AIDS-226764

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone deacetylase 0.0045 0.0084 0.0084
Schistosoma mansoni lamin 0.004 0.0053 0.0053
Toxoplasma gondii histone deacetylase HDAC3 0.0045 0.0084 0.0063
Loa Loa (eye worm) hypothetical protein 0.0336 0.1787 0.3906
Loa Loa (eye worm) hypothetical protein 0.0336 0.1787 0.3906
Echinococcus granulosus tm gpcr rhodopsin 0.0611 0.3391 0.3362
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0255 0.1311 0.5816
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0048 0.0099 0.0216
Brugia malayi hypothetical protein 0.0116 0.0499 0.1092
Trichomonas vaginalis D-aminoacylase, putative 0.0048 0.0099 0.0476
Leishmania major histone deacetylase, putative 0.0098 0.0395 0.1446
Echinococcus granulosus expressed conserved protein 0.0083 0.0308 0.0266
Echinococcus granulosus lipoxygenase domain containing protein 0.0302 0.1586 0.1549
Loa Loa (eye worm) hypothetical protein 0.0074 0.0256 0.0559
Brugia malayi peptidase family M13 containing protein 0.0047 0.0092 0.0202
Brugia malayi gamma-secretase subunit aph-1 0.0568 0.3142 0.6868
Onchocerca volvulus Matrix metalloproteinase homolog 0.0746 0.4182 1
Trypanosoma cruzi presenilin-like aspartic peptidase, putative 0.0238 0.1213 0.5372
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0351 0.0768
Plasmodium falciparum histone deacetylase, putative 0.0098 0.0395 0.0831
Plasmodium falciparum peptide deformylase 0.0684 0.3821 1
Mycobacterium leprae PROBABLE HYDROLASE 0.041 0.2215 0.5687
Loa Loa (eye worm) hypothetical protein 0.0116 0.0499 0.1092
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0351 0.031
Echinococcus granulosus histone deacetylase 1 0.0045 0.0084 0.0042
Echinococcus granulosus tumor protein p63 0.0305 0.1601 0.1565
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0096 0.0384 0.0384
Trypanosoma cruzi Aph-1 protein, putative 0.0221 0.1115 0.4924
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0336 0.1787 0.1787
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.004 0.0053 0.0117
Loa Loa (eye worm) doublecortin family protein 0.0302 0.1586 0.3466
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0096 0.0384 0.0384
Schistosoma mansoni hypothetical protein 0.005 0.0112 0.0112
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0082 0.0302 0.0302
Trypanosoma brucei histone deacetylase, putative 0.0098 0.0395 0.1657
Loa Loa (eye worm) hypothetical protein 0.0144 0.0665 0.1453
Loa Loa (eye worm) matrixin family protein 0.0813 0.4575 1
Schistosoma mansoni hypothetical protein 0.0037 0.0035 0.0035
Schistosoma mansoni patched 1 0.0038 0.0043 0.0043
Brugia malayi Doublecortin family protein 0.0302 0.1586 0.3466
Loa Loa (eye worm) hypothetical protein 0.0062 0.0184 0.0401
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.041 0.2215 0.4842
Echinococcus multilocularis gamma secretase subunit aph 1 0.0568 0.3142 0.3112
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0099 0.0038
Schistosoma mansoni histone deacetylase 4 5 0.0098 0.0395 0.0395
Echinococcus granulosus presenilin enhancer 2 0.0224 0.1128 0.109
Trichomonas vaginalis histone deacetylase, putative 0.0045 0.0084 0.0354
Brugia malayi hypothetical protein 0.0051 0.0117 0.0255
Schistosoma mansoni hypothetical protein 0.005 0.0112 0.0112
Toxoplasma gondii histone deacetylase HDAC2 0.0045 0.0084 0.0063
Schistosoma mansoni gamma-secretase subunit aph-1 0.0568 0.3142 0.3142
Loa Loa (eye worm) hypothetical protein 0.0302 0.1586 0.3466
Echinococcus granulosus lipoxygenase domain containing protein 0.0302 0.1586 0.1549
Echinococcus multilocularis protein dispatched 1 0.0043 0.0075 0.0032
Schistosoma mansoni lipoxygenase 0.1741 1 1
Leishmania major polypeptide deformylase-like protein, putative 0.0261 0.1347 0.5876
Loa Loa (eye worm) histone deacetylase 1 0.0045 0.0084 0.0185
Schistosoma mansoni polycystin 1-related 0.0302 0.1586 0.1586
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0238 0.1213 1
Echinococcus granulosus Niemann Pick C1 protein 0.0127 0.0562 0.0521
Echinococcus multilocularis histone deacetylase 0.0098 0.0395 0.0354
Trichomonas vaginalis D-aminoacylase, putative 0.0048 0.0099 0.0476
Brugia malayi Protein kinase domain containing protein 0.0039 0.005 0.011
Trypanosoma cruzi histone deacetylase 1, putative 0.0045 0.0084 0.0247
Schistosoma mansoni neprilysin 0.005 0.0112 0.0112
Onchocerca volvulus 0.0109 0.0456 0.0974
Schistosoma mansoni subfamily A22A unassigned peptidase (A22 family) 0.0238 0.1213 0.1213
Entamoeba histolytica hypothetical protein 0.0051 0.0117 0.0409
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0261 0.1347 0.5978
Schistosoma mansoni histone deacetylase hda2 0.0098 0.0395 0.0395
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0684 0.3821 1
Echinococcus multilocularis histone deacetylase 3 0.0045 0.0084 0.0042
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0191 0.0937 0.2048
Echinococcus multilocularis presenilin 0.0238 0.1213 0.1175
Echinococcus multilocularis lamin 0.004 0.0053 0.001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0045 0.0083 0.0182
Loa Loa (eye worm) hypothetical protein 0.0141 0.0645 0.1411
Schistosoma mansoni transcription factor LCR-F1 0.0051 0.0117 0.0117
Brugia malayi Matrixin family protein 0.0813 0.4575 1
Schistosoma mansoni rab6-interacting 0.0302 0.1586 0.1586
Echinococcus multilocularis nicalin 0.0043 0.007 0.0027
Trypanosoma cruzi Nicastrin, putative 0.0043 0.007 0.0181
Toxoplasma gondii hypothetical protein 0.0067 0.0214 0.0407
Loa Loa (eye worm) hypothetical protein 0.0045 0.0084 0.0185
Schistosoma mansoni endothelin-converting enzyme-related 0.0047 0.0092 0.0092
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0045 0.0084 0.0354
Loa Loa (eye worm) hypothetical protein 0.0413 0.2233 0.4881
Loa Loa (eye worm) hypothetical protein 0.0048 0.0099 0.0216
Giardia lamblia Histone deacetylase 0.0045 0.0084 0.5
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.1223 0.697 0.6957
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0351 0.031
Echinococcus multilocularis Niemann Pick C1 protein 0.0127 0.0562 0.0521
Brugia malayi hypothetical protein 0.0533 0.2935 0.6415
Trichomonas vaginalis histone deacetylase, putative 0.0045 0.0084 0.0354
Trichomonas vaginalis D-aminoacylase, putative 0.0048 0.0099 0.0476
Trichomonas vaginalis AGC family protein kinase 0.0039 0.005 0.0063
Loa Loa (eye worm) hypothetical protein 0.0089 0.0339 0.0742
Brugia malayi Kelch motif family protein 0.0056 0.0148 0.0324
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0074 0.0256 0.1624
Echinococcus multilocularis microtubule associated protein 2 0.0622 0.3457 0.3429
Plasmodium vivax peptide deformylase, putative 0.0684 0.3821 1
Loa Loa (eye worm) hypothetical protein 0.0336 0.1787 0.3906
Brugia malayi histone deacetylase 3 (HD3) 0.0045 0.0084 0.0185
Plasmodium falciparum LCCL domain-containing protein 0.0302 0.1586 0.4018
Echinococcus multilocularis survival motor neuron protein 1 0.0533 0.2935 0.2904
Schistosoma mansoni survival motor neuron protein 0.0109 0.0456 0.0456
Onchocerca volvulus 0.0302 0.1586 0.3711
Loa Loa (eye worm) histone deacetylase 7A 0.0098 0.0395 0.0864
Schistosoma mansoni niemann-pick C1 (NPC1) 0.009 0.0347 0.0347
Schistosoma mansoni intermediate filament proteins 0.004 0.0053 0.0053
Echinococcus granulosus histone deacetylase 6 0.0098 0.0395 0.0354
Loa Loa (eye worm) hypothetical protein 0.0095 0.0373 0.0816
Chlamydia trachomatis peptide deformylase 0.0684 0.3821 0.5
Echinococcus multilocularis presenilin enhancer 2 0.0224 0.1128 0.109
Trypanosoma cruzi Peptide deformylase 2, putative 0.0261 0.1347 0.5978
Trypanosoma cruzi Aph-1 protein, putative 0.0221 0.1115 0.4924
Loa Loa (eye worm) peptidase family M13 containing protein 0.0141 0.0645 0.1411
Brugia malayi Presenilin family protein 0.0238 0.1213 0.2652
Echinococcus granulosus beta LACTamase domain containing family member 0.0048 0.0099 0.0056
Echinococcus granulosus presenilin 0.0238 0.1213 0.1175
Brugia malayi Presenilin spe-4 0.0083 0.0308 0.0674
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0238 0.1213 1
Onchocerca volvulus 0.0048 0.0099 0.011
Echinococcus granulosus histone deacetylase 0.0098 0.0395 0.0354
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0351 0.0768
Trypanosoma cruzi Peptide deformylase 2, putative 0.0261 0.1347 0.5978
Echinococcus multilocularis histone deacetylase 1 0.0045 0.0084 0.0042
Schistosoma mansoni lamin 0.004 0.0053 0.0053
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0045 0.0084 0.0354
Schistosoma mansoni hypothetical protein 0.0051 0.0117 0.0117
Trypanosoma cruzi histone deacetylase 1, putative 0.0045 0.0084 0.0247
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0684 0.3821 1
Loa Loa (eye worm) hypothetical protein 0.0144 0.0665 0.1453
Loa Loa (eye worm) hypothetical protein 0.0141 0.0645 0.1411
Leishmania major hypothetical protein, conserved 0.0067 0.0214 0.0602
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0351 0.031
Trichomonas vaginalis histone deacetylase, putative 0.0045 0.0084 0.0354
Trichomonas vaginalis AGC family protein kinase 0.0039 0.005 0.0063
Echinococcus multilocularis tumor protein p63 0.0305 0.1601 0.1565
Schistosoma mansoni histone deacetylase 0.0045 0.0084 0.0084
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0351 0.0351
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0351 0.031
Loa Loa (eye worm) zinc metallopeptidase 4 0.0047 0.0092 0.0202
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0351 0.0351
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0684 0.3821 0.5
Entamoeba histolytica presenilin 1 peptidase, putative 0.0238 0.1213 1
Echinococcus granulosus microtubule associated protein 2 0.0622 0.3457 0.3429
Brugia malayi hypothetical protein 0.0302 0.1586 0.3466
Trypanosoma brucei Polypeptide deformylase 1 0.0261 0.1347 0.5978
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0568 0.3142 0.6868
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0048 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0045 0.0083 0.0182
Loa Loa (eye worm) hypothetical protein 0.0048 0.0099 0.0216
Plasmodium vivax histone deacetylase, putative 0.0098 0.0395 0.0831
Brugia malayi Histone deacetylase 1 0.0045 0.0084 0.0185
Echinococcus multilocularis expressed conserved protein 0.0083 0.0308 0.0266
Schistosoma mansoni rab6-interacting 0.0302 0.1586 0.1586
Echinococcus multilocularis lamin dm0 0.004 0.0053 0.001
Trypanosoma cruzi histone deacetylase, putative 0.0098 0.0395 0.1657
Echinococcus granulosus intermediate filament protein 0.004 0.0053 0.001
Brugia malayi hypothetical protein 0.0083 0.0308 0.0674
Brugia malayi Hemopexin family protein 0.0477 0.2609 0.5702
Brugia malayi Presenilin spe-4 0.0083 0.0308 0.0674
Loa Loa (eye worm) hypothetical protein 0.0045 0.0081 0.0177
Schistosoma mansoni hypothetical protein 0.0116 0.0499 0.0499
Trypanosoma cruzi histone deacetylase, putative 0.0098 0.0395 0.1657
Schistosoma mansoni histone deacetylase 4 5 0.0098 0.0395 0.0395
Brugia malayi Matrixin family protein 0.0336 0.1787 0.3906
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0045 0.0084 0.0354
Schistosoma mansoni microsomal glutathione s-transferase 0.0073 0.0246 0.0246
Schistosoma mansoni hypothetical protein 0.0037 0.0035 0.0035
Toxoplasma gondii hypothetical protein 0.0083 0.0308 0.0658
Brugia malayi hypothetical protein 0.0083 0.0308 0.0674
Trypanosoma cruzi Nicastrin, putative 0.0043 0.007 0.0181
Echinococcus multilocularis lipoxygenase domain containing protein 0.0302 0.1586 0.1549
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0611 0.3391 0.3362
Trichomonas vaginalis penicillin-binding protein, putative 0.0048 0.0099 0.0476
Onchocerca volvulus 0.0095 0.0373 0.0775
Echinococcus granulosus lamin 0.004 0.0053 0.001
Trypanosoma brucei C-8 sterol isomerase, putative 0.0413 0.2233 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0302 0.1586 0.1549
Loa Loa (eye worm) hypothetical protein 0.0191 0.0937 0.2048
Trypanosoma cruzi histone deacetylase, putative 0.0098 0.0395 0.1657
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0048 0.0099 0.0099
Schistosoma mansoni microtubule-associated protein tau 0.0622 0.3457 0.3457
Echinococcus granulosus histone deacetylase 3 0.0045 0.0084 0.0042
Loa Loa (eye worm) hypothetical protein 0.0191 0.0937 0.2048
Trypanosoma brucei Aph-1 protein, putative 0.0221 0.1115 0.4924
Brugia malayi Matrixin family protein 0.0336 0.1787 0.3906
Toxoplasma gondii hypothetical protein 0.0684 0.3821 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0089 0.0339 0.0297
Schistosoma mansoni lipoxygenase 0.1197 0.6823 0.6823
Trichomonas vaginalis esterase, putative 0.0048 0.0099 0.0476
Brugia malayi CHE-14 protein 0.0038 0.0043 0.0094
Echinococcus granulosus microsomal glutathione S transferase 3 0.0073 0.0246 0.0204
Loa Loa (eye worm) matrixin family protein 0.0746 0.4182 0.9141
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.0099 0.0312
Echinococcus multilocularis integrin beta 2 0.0261 0.135 0.1312
Loa Loa (eye worm) hypothetical protein 0.0144 0.0665 0.1453
Schistosoma mansoni hypothetical protein 0.0302 0.1586 0.1586
Onchocerca volvulus 0.0048 0.0099 0.011
Brugia malayi beta-lactamase family protein 0.0048 0.0099 0.0216
Onchocerca volvulus Matrilysin homolog 0.0746 0.4182 1
Loa Loa (eye worm) gamma-secretase subunit pen-2 0.0224 0.1128 0.2465
Toxoplasma gondii histone deacetylase HDAC1 0.0098 0.0395 0.0889
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0121 0.0526 0.2251
Brugia malayi Peptidase family M13 containing protein 0.0191 0.0937 0.2048
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0191 0.0937 0.0937
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0047 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0211 0.1053 0.2303
Echinococcus granulosus nicalin 0.0043 0.007 0.0027
Echinococcus multilocularis Nicastrin 0.0116 0.0499 0.0458
Loa Loa (eye worm) hypothetical protein 0.0062 0.0184 0.0401
Loa Loa (eye worm) hypothetical protein 0.0048 0.0099 0.0216
Loa Loa (eye worm) hypothetical protein 0.0085 0.032 0.0699
Brugia malayi hypothetical protein 0.0116 0.0499 0.1092
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0047 0.0092 0.0092
Trypanosoma brucei Presenilin enhancer-2 subunit of gamma secretase, putative 0.0067 0.0214 0.0834
Schistosoma mansoni hypothetical protein 0.0477 0.2609 0.2609
Entamoeba histolytica hypothetical protein 0.0051 0.0117 0.0409
Leishmania major histone deacetylase, putative 0.0098 0.0395 0.1446
Brugia malayi beta-lactamase 0.0048 0.0099 0.0216
Echinococcus granulosus RUN 0.0302 0.1586 0.1549
Toxoplasma gondii ABC1 family protein 0.0048 0.0099 0.0101
Brugia malayi hypothetical protein 0.0302 0.1586 0.3466
Trypanosoma brucei histone deacetylase 1 0.0045 0.0084 0.0247
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.1741 1 1
Onchocerca volvulus Huntingtin homolog 0.0062 0.0184 0.0315
Trichomonas vaginalis histone deacetylase, putative 0.0045 0.0084 0.0354
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0255 0.1311 0.5816
Trichomonas vaginalis Nicastrin precursor, putative 0.0116 0.0499 0.3899
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.0099 0.0312
Brugia malayi Niemann-Pick C1 protein precursor 0.0089 0.0339 0.0742
Loa Loa (eye worm) integrin beta-2 0.0357 0.1909 0.4172
Echinococcus multilocularis RUN 0.0302 0.1586 0.1549
Schistosoma mansoni hypothetical protein 0.005 0.0112 0.0112
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0047 0.0092 0.0092
Mycobacterium ulcerans hydrolase 0.041 0.2215 0.5687
Leishmania major C-8 sterol isomerase-like protein 0.0413 0.2233 1
Echinococcus granulosus histone deacetylase 6 0.0098 0.0395 0.0354
Loa Loa (eye worm) hypothetical protein 0.0144 0.0665 0.1453
Brugia malayi Presenilin spe-4 0.0083 0.0308 0.0674
Echinococcus granulosus Polycystic kidney disease protein 0.0302 0.1586 0.1549
Echinococcus granulosus histone deacetylase 6 0.0098 0.0395 0.0354
Loa Loa (eye worm) hypothetical protein 0.0038 0.0043 0.0094
Brugia malayi Intermediate filament tail domain containing protein 0.004 0.0053 0.0117
Trypanosoma cruzi presenilin-like aspartic peptidase, putative 0.0238 0.1213 0.5372
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0047 0.0092 0.0092
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0121 0.0526 0.2055
Echinococcus multilocularis histone deacetylase 7 0.0098 0.0395 0.0354
Echinococcus multilocularis histone deacetylase 6 0.0098 0.0395 0.0354
Brugia malayi hypothetical protein 0.0083 0.0308 0.0674
Mycobacterium tuberculosis Conserved hypothetical protein 0.0134 0.0606 0.1362
Loa Loa (eye worm) hypothetical protein 0.0302 0.1586 0.3466
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0109 0.0456 0.0996
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0039 0.005 0.011
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1415 0.8097 0.8089
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0238 0.1213 1
Loa Loa (eye worm) presenilin spe-4 0.0083 0.0308 0.0674
Onchocerca volvulus 0.0336 0.1787 0.4199
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0051 0.0117 0.0074
Loa Loa (eye worm) hypothetical protein 0.0039 0.0049 0.0107
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0076 0.0208
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.1223 0.697 0.6957
Loa Loa (eye worm) intermediate filament protein 0.004 0.0053 0.0117
Entamoeba histolytica histone deacetylase, putative 0.0045 0.0084 0.0128
Schistosoma mansoni hypothetical protein 0.0109 0.0456 0.0456
Schistosoma mansoni hypothetical protein 0.005 0.0112 0.0112
Entamoeba histolytica hypothetical protein 0.0051 0.0117 0.0409
Onchocerca volvulus 0.0477 0.2609 0.6189
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.041 0.2215 0.5687
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0051 0.0117 0.0074
Leishmania major presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative 0.0238 0.1213 0.5255
Loa Loa (eye worm) histone deacetylase 0.0098 0.0395 0.0864
Loa Loa (eye worm) peptidase family M13 containing protein 0.0141 0.0645 0.1411
Leishmania major hypothetical protein, conserved 0.0048 0.0099 0.0067
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0047 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.004 0.0053 0.0117
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0096 0.0384 0.0384
Plasmodium falciparum histone deacetylase 2 0.0098 0.0395 0.0831
Echinococcus granulosus Niemann Pick C1 protein 0.0089 0.0339 0.0297
Loa Loa (eye worm) hypothetical protein 0.0144 0.0665 0.1453
Loa Loa (eye worm) hypothetical protein 0.0141 0.0645 0.1411
Brugia malayi hypothetical protein 0.0062 0.0184 0.0401
Onchocerca volvulus Huntingtin homolog 0.0062 0.0184 0.0315
Loa Loa (eye worm) hypothetical protein 0.0047 0.0093 0.0204
Echinococcus granulosus integrin beta 2 0.0261 0.135 0.1312
Loa Loa (eye worm) hypothetical protein 0.0056 0.0148 0.0324
Brugia malayi beta-lactamase family protein 0.0048 0.0099 0.0216
Loa Loa (eye worm) hypothetical protein 0.0048 0.0099 0.0216
Echinococcus multilocularis endothelin converting enzyme 1 0.0191 0.0937 0.0898
Loa Loa (eye worm) hypothetical protein 0.0144 0.0665 0.1453
Leishmania major mitochondrial DNA polymerase beta 0.0255 0.1311 0.571
Plasmodium vivax histone deacetylase 2, putative 0.0098 0.0395 0.0831
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0096 0.0384 0.0384
Onchocerca volvulus Matrilysin homolog 0.0336 0.1787 0.4199
Brugia malayi Matrixin family protein 0.0336 0.1787 0.3906
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0074 0.0256 0.1624
Loa Loa (eye worm) hypothetical protein 0.0048 0.0099 0.0216
Loa Loa (eye worm) hypothetical protein 0.0533 0.2935 0.6415
Onchocerca volvulus 0.0302 0.1586 0.3711
Echinococcus granulosus Nicastrin 0.0116 0.0499 0.0458
Loa Loa (eye worm) histone deacetylase 3 0.0045 0.0084 0.0185
Trypanosoma brucei Nicastrin, putative 0.0043 0.007 0.0181
Trichomonas vaginalis histone deacetylase, putative 0.0045 0.0084 0.0354
Brugia malayi Integrin beta pat-3 precursor 0.0357 0.1909 0.4172
Brugia malayi Matrixin family protein 0.0336 0.1787 0.3906
Trypanosoma brucei hypothetical protein, conserved 0.0048 0.0099 0.0312
Mycobacterium leprae probable zinc metalloprotease 0.0191 0.0937 0.2251
Echinococcus multilocularis beta LACTamase domain containing family member 0.0048 0.0099 0.0056
Schistosoma mansoni hypothetical protein 0.005 0.0112 0.0112
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0056 0.0148 0.0324
Echinococcus granulosus survival motor neuron protein 1 0.0533 0.2935 0.2904
Schistosoma mansoni hypothetical protein 0.005 0.0112 0.0112
Brugia malayi histone deacetylase 1 (HD1) 0.0045 0.0084 0.0185
Mycobacterium ulcerans peptide deformylase 0.0684 0.3821 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0045 0.0083 0.0182
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0073 0.0246 0.0204
Brugia malayi Presenilin-like protein At2g29900 0.0083 0.0308 0.0674
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0413 0.2233 1
Schistosoma mansoni loxhd1 0.0302 0.1586 0.1586
Brugia malayi Histone deacetylase family protein 0.0098 0.0395 0.0864
Schistosoma mansoni neprilysin-2 (M13 family) 0.0096 0.0384 0.0384
Echinococcus multilocularis lipoxygenase domain containing protein 0.0302 0.1586 0.1549
Loa Loa (eye worm) beta-lactamase 0.0048 0.0099 0.0216
Schistosoma mansoni cellular tumor antigen P53 0.0045 0.0081 0.0081
Trypanosoma brucei Peptide deformylase 2 0.0261 0.1347 0.5978
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0255 0.1311 0.5816
Loa Loa (eye worm) hypothetical protein 0.0141 0.0645 0.1411
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0191 0.0937 0.2251
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0261 0.1347 0.5978
Brugia malayi hypothetical protein 0.0056 0.0148 0.0324
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0121 0.0526 0.2251
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0039 0.0047 0.0036
Loa Loa (eye worm) hypothetical protein 0.0085 0.032 0.0699
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0317 0.1677 0.1677
Loa Loa (eye worm) matrix metalloproteinase 0.0336 0.1787 0.3906
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0038 0.0043 0.0094
Brugia malayi gamma-secretase subunit pen-2 0.0224 0.1128 0.2465
Brugia malayi Histone deacetylase family protein 0.0098 0.0395 0.0864
Echinococcus granulosus lamin dm0 0.004 0.0053 0.001
Schistosoma mansoni integrin beta subunit 0.0205 0.1022 0.1022
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0304 0.1599 0.4031
Treponema pallidum polypeptide deformylase (def) 0.0684 0.3821 0.5
Loa Loa (eye worm) hypothetical protein 0.0191 0.0937 0.2048
Brugia malayi intermediate filament protein 0.004 0.0053 0.0117
Echinococcus granulosus gamma secretase subunit aph 1 0.0568 0.3142 0.3112
Trichomonas vaginalis penicillin-binding protein, putative 0.0048 0.0099 0.0476
Onchocerca volvulus 0.0048 0.0099 0.011
Toxoplasma gondii peptidase family M13 protein 0.0191 0.0937 0.233
Trichomonas vaginalis histone deacetylase, putative 0.0045 0.0084 0.0354
Loa Loa (eye worm) hypothetical protein 0.041 0.2215 0.4842
Echinococcus multilocularis Nicastrin 0.0116 0.0499 0.0458
Onchocerca volvulus 0.0045 0.0081 0.0067
Mycobacterium ulcerans zinc metalloprotease 0.0191 0.0937 0.2251
Echinococcus granulosus histone deacetylase 7 0.0098 0.0395 0.0354
Echinococcus multilocularis musashi 0.004 0.0053 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0351 0.0351
Trichomonas vaginalis AGC family protein kinase 0.0039 0.005 0.0063
Plasmodium vivax multidomain scavenger receptor, putative 0.0302 0.1586 0.4018
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0413 0.2233 0.4881
Echinococcus multilocularis histone deacetylase 6 0.0098 0.0395 0.0354
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.005 0.0112 0.0112
Toxoplasma gondii MAPEG family protein 0.0073 0.0246 0.0492
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0048 0.0099 0.0216
Trichomonas vaginalis Nicastrin precursor, putative 0.0116 0.0499 0.3899
Trypanosoma brucei histone deacetylase 3 0.0098 0.0395 0.1657
Mycobacterium ulcerans hypothetical protein 0.0134 0.0606 0.1362
Entamoeba histolytica hypothetical protein 0.0051 0.0117 0.0409
Loa Loa (eye worm) hypothetical protein 0.0048 0.0099 0.0216
Echinococcus granulosus endothelin converting enzyme 1 0.0191 0.0937 0.0898
Schistosoma mansoni hypothetical protein 0.0037 0.0035 0.0035
Brugia malayi Calcitonin receptor-like protein seb-1 0.0045 0.0083 0.0182
Trypanosoma brucei presenilin-like aspartic peptidase, putative 0.0238 0.1213 0.5372
Echinococcus multilocularis histone deacetylase 6 0.0098 0.0395 0.0354
Schistosoma mansoni hypothetical protein 0.0037 0.0035 0.0035
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0089 0.0339 0.2356
Trypanosoma brucei histone deacetylase 4 0.0098 0.0395 0.1657

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) = 28 ug ml-1 Cytotoxic concentration required to reduce cell growth by 50% ChEMBL. 15689173
CC50 (functional) = 28 ug ml-1 Cytotoxic concentration required to reduce cell growth by 50% ChEMBL. 15689173
EC50 (functional) = 7.3 ug ml-1 Effective concentration of the compound against AD-169 strain of CMV virus expressed in HEL cells ChEMBL. 15689173
EC50 (functional) = 8.9 ug ml-1 Effective concentration of the compound against Davis strain strain of CMV virus expressed in HEL cells ChEMBL. 15689173
IC50 (functional) = 10 uM Inhibitory concentration of thecompound was determined against SW6 20 cell line ChEMBL. 15689173
IC50 (functional) = 10 uM Inhibitory concentration of thecompound was determined against SW6 20 cell line ChEMBL. 15689173
IC50 (functional) = 16 uM Inhibitory concentration of thecompound was determined against L1210 cell line ChEMBL. 15689173
IC50 (functional) = 16 uM Inhibitory concentration of thecompound was determined against L1210 cell line ChEMBL. 15689173
IC50 (functional) = 17 uM Inhibitory concentration ofthecompound was determinedagainst CEM cell line ChEMBL. 15689173
IC50 (functional) = 17 uM Inhibitory concentration ofthecompound was determinedagainst CEM cell line ChEMBL. 15689173
IC50 (functional) = 19 uM Inhibitory concentration of thecompound was determined againstMolt 4/C8 cell line ChEMBL. 15689173
IC50 (functional) = 19 uM Inhibitory concentration of thecompound was determined againstMolt 4/C8 cell line ChEMBL. 15689173
IC50 (functional) = 20 uM Inhibitory concentration of thecompound was determined against MiaPaCa2 cell line ChEMBL. 15689173
IC50 (functional) = 20 uM Inhibitory concentration of thecompound was determined against MiaPaCa2 cell line ChEMBL. 15689173
IC50 (functional) = 30 uM Inhibitory concentrationof thecompound was determined againstHeLa cell line ChEMBL. 15689173
IC50 (functional) = 30 uM Inhibitory concentrationof thecompound was determined againstHeLa cell line ChEMBL. 15689173
IC50 (functional) = 40 uM Inhibitory concentration of thecompound was determined against Hep2 cell line ChEMBL. 15689173
IC50 (functional) = 40 uM Inhibitory concentration of thecompound was determined against Hep2 cell line ChEMBL. 15689173
IC50 (functional) = 80 uM Inhibitory concentration of thecompound was determined against MCF-7 cell line ChEMBL. 15689173
IC50 (functional) = 80 uM Inhibitory concentration of thecompound was determined against MCF-7 cell line ChEMBL. 15689173
IC50 (functional) = 100 uM Inhibitory concentration of thecompound was determined against W138 cell line ChEMBL. 15689173
MCC (functional) >= 20 ug ml-1 Minimum cytotoxic concentration that causes a microscopically detectable alteration of cell morphology ChEMBL. 15689173
MCC (functional) >= 20 ug ml-1 Minimum cytotoxic concentration that causes a microscopically detectable alteration of cell morphology ChEMBL. 15689173

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 15689173
Mus musculus ChEMBL23 15689173

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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