Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Oxytocin receptor | Starlite/ChEMBL | References |
Homo sapiens | oxytocin receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | allatostatin A receptor | Oxytocin receptor | 388 aa | 311 aa | 21.9 % |
Onchocerca volvulus | Phospholipase d-related homolog | Oxytocin receptor | 388 aa | 330 aa | 20.0 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Oxytocin receptor | 388 aa | 349 aa | 22.9 % |
Echinococcus multilocularis | orexin receptor type 2 | Oxytocin receptor | 388 aa | 332 aa | 23.2 % |
Echinococcus granulosus | allatostatin A receptor | Oxytocin receptor | 388 aa | 313 aa | 23.6 % |
Echinococcus granulosus | orexin receptor type 2 | Oxytocin receptor | 388 aa | 338 aa | 24.3 % |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Oxytocin receptor | 388 aa | 323 aa | 21.7 % |
Echinococcus granulosus | neuropeptide receptor | Oxytocin receptor | 388 aa | 324 aa | 21.9 % |
Onchocerca volvulus | Oxytocin receptor | 388 aa | 327 aa | 23.9 % | |
Echinococcus multilocularis | neuropeptide receptor | Oxytocin receptor | 388 aa | 324 aa | 21.6 % |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Oxytocin receptor | 388 aa | 327 aa | 19.3 % |
Onchocerca volvulus | Mitochondrial inner membrane protein homolog | Oxytocin receptor | 388 aa | 346 aa | 24.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0229 | 0.5 | 0.5 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0229 | 0.5 | 0.5 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.0229 | 0.5 | 0.5 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0229 | 0.5 | 0.5 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0229 | 0.5 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0229 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0229 | 0.5 | 0.5 | |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.0229 | 0.5 | 0.5 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0229 | 0.5 | 0.5 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0229 | 0.5 | 0.5 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0229 | 0.5 | 0.5 |
Plasmodium falciparum | polyprenol reductase, putative | 0.0229 | 0.5 | 0.5 |
Entamoeba histolytica | 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein | 0.0229 | 0.5 | 0.5 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0229 | 0.5 | 0.5 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0229 | 0.5 | 0.5 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.0229 | 0.5 | 0.5 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0229 | 0.5 | 0.5 |
Entamoeba histolytica | trans-2,3-enoyl-CoA reductase, putative | 0.0229 | 0.5 | 0.5 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0229 | 0.5 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0229 | 0.5 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0229 | 0.5 | 0.5 |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.0229 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.5 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0229 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.5 | 0.5 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0229 | 0.5 | 0.5 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0229 | 0.5 | 0.5 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.0229 | 0.5 | 0.5 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0229 | 0.5 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0229 | 0.5 | 0.5 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0229 | 0.5 | 0.5 |
Plasmodium vivax | polyprenol reductase, putative | 0.0229 | 0.5 | 0.5 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0229 | 0.5 | 0.5 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0229 | 0.5 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0229 | 0.5 | 0.5 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.0229 | 0.5 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0229 | 0.5 | 0.5 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0229 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 9.8 nM | Binding affinity for human oxytocin receptor | ChEMBL. | 10340620 |
Ki (binding) | = 9.8 nM | Binding affinity for human oxytocin receptor | ChEMBL. | 10340620 |
Ki (binding) | = 36 nM | Binding affinity for rat uterine oxytocin receptor (rOTr) | ChEMBL. | 10340620 |
Ki (binding) | = 36 nM | Binding affinity for rat uterine oxytocin receptor (rOTr) | ChEMBL. | 10340620 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.