TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 331.343 | Formula: C16H13NO5S
H donors: 1 H acceptors: 4 LogP: 2.73 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc2c(c1)n(cc2)S(=O)(=O)c1ccccc1C(=O)O
InChi: 1S/C16H13NO5S/c1-22-12-7-6-11-8-9-17(14(11)10-12)23(20,21)15-5-3-2-4-13(15)16(18)19/h2-10H,1H3,(H,18,19)
InChiKey: HQQRNJVZOJLXOO-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	fatty acid binding protein 4, adipocyte	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Lipocalin / cytosolic fatty-acid binding protein family protein	Get druggable targets OG5_144191	All targets in OG5_144191
Loa Loa (eye worm)	lipocalin/cytosolic fatty-acid binding protein family protein	Get druggable targets OG5_144191	All targets in OG5_144191

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Fatty acid-binding protein homolog precursor	fatty acid binding protein 4, adipocyte	132 aa	142 aa	24.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	cathepsin L-like precursor	0.0011	0.004	0.0085
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0006	0.0011	0.0286
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0076	0.0161
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0044	0.0275	0.1833
Loa Loa (eye worm)	hypothetical protein	0.0011	0.004	0.0085
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0061	0.0388	0.0384
Trichomonas vaginalis	DNA helicase recq, putative	0.0012	0.0051	0.0083
Onchocerca volvulus		0.0016	0.0076	0.011
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0076	0.2713
Echinococcus multilocularis	cysteine protease	0.0016	0.0076	0.0053
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0015	0.0074	0.0314
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0046	0.0289	0.1268
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0009	0.0032	0.0008
Brugia malayi	hypothetical protein	0.0258	0.1757	0.4056
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0046	0.0289	0.1268
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0011	0.0045	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0163	0.1098	0.2531
Trypanosoma brucei	trypanothione reductase	0.0044	0.0275	0.1129
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0156	0.1049	0.46
Entamoeba histolytica	cysteine proteinase, putative	0.0008	0.0023	0.0829
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0023	0.0829
Plasmodium falciparum	thioredoxin reductase	0.0015	0.0074	0.1963
Plasmodium vivax	SET domain protein, putative	0.0061	0.0388	1
Leishmania major	mitochondrial DNA polymerase beta	0.033	0.2254	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0076	0.0161
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0076	0.0161
Trypanosoma cruzi	cysteine proteinase, putative	0.0008	0.0023	0.0089
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0015	0.0074	0.0051
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0023	0.0829
Plasmodium vivax	thioredoxin reductase, putative	0.0044	0.0275	0.7074
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0101	0.067	0.5427
Loa Loa (eye worm)	RecQ helicase	0.0023	0.0123	0.0278
Echinococcus multilocularis	survival motor neuron protein 1	0.0258	0.1757	0.1738
Entamoeba histolytica	hypothetical protein	0.0034	0.0201	0.7175
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0011	0.0045	0.0098
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0076	0.0161
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0076	0.0161
Toxoplasma gondii	cathepsin CPL	0.0016	0.0076	0.1965
Echinococcus multilocularis	lamin dm0	0.0025	0.0143	0.012
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0034	0.0201	0.0179
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.033	0.2254	1
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0015	0.0074	0.1963
Loa Loa (eye worm)	cysteine protease	0.0016	0.0076	0.0169
Loa Loa (eye worm)	glutathione reductase	0.0044	0.0275	0.0629
Schistosoma mansoni	lamin	0.0025	0.0143	0.014
Trichomonas vaginalis	DNA helicase recq, putative	0.0023	0.0123	0.0305
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.004	0.0051
Schistosoma mansoni	hypothetical protein	0.0034	0.0201	0.0198
Mycobacterium tuberculosis	Probable dehydrogenase	0.0101	0.067	0.5427
Echinococcus granulosus	thioredoxin glutathione reductase	0.0044	0.0275	0.0252
Entamoeba histolytica	hypothetical protein	0.0026	0.0144	0.5135
Trypanosoma cruzi	cruzipain precursor, putative	0.006	0.0383	0.1686
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0076	0.0161
Echinococcus granulosus	bloom syndrome protein	0.0023	0.0123	0.01
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0023	0.0829
Entamoeba histolytica	cysteine proteinase 2	0.0008	0.0023	0.0829
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0026	0.0144	1
Plasmodium vivax	unspecified product	0.0008	0.0023	0.0524
Entamoeba histolytica	acetyltransferase, GNAT family	0.0045	0.0281	1
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0015	0.0074	0.0105
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0046	0.0289	0.119
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0076	0.0073
Onchocerca volvulus		0.0016	0.0076	0.011
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0076	0.0053
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0091	0.0597	0.1372
Schistosoma mansoni	lamin	0.0025	0.0143	0.014
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0076	0.0169
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0076	0.0161
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0057	0.0359	0.1581
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.0383	0.1611
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0008	0.0023	0.002
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0076	0.0161
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0015	0.0074	0.0314
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0061	0.0388	0.0365
Echinococcus multilocularis	muscleblind protein 1	0.0163	0.1098	0.1077
Schistosoma mansoni	DNA helicase recq5	0.0009	0.0032	0.0028
Echinococcus multilocularis	cysteine protease	0.0016	0.0076	0.0053
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0016	0.0076	0.0169
Loa Loa (eye worm)	thioredoxin reductase	0.0044	0.0275	0.0629
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0091	0.0597	0.0575
Trypanosoma cruzi	trypanothione reductase, putative	0.0044	0.0275	0.1208
Entamoeba histolytica	cysteine proteinase 1, putative	0.0008	0.0023	0.0829
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0076	0.0161
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0015	0.0074	0.0227
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0023	0.0829
Echinococcus granulosus	lamin dm0	0.0025	0.0143	0.012
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.0383	0.1611
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0015	0.0073	0.1812
Brugia malayi	Thioredoxin reductase	0.0044	0.0275	0.0629
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0076	0.0053
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0026	0.0144	0.0641
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0055	0.0347	0.1526
Brugia malayi	glutathione reductase	0.0044	0.0275	0.0629
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0076	0.0169
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0044	0.0275	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0011	0.004	0.0085
Leishmania major	cathepsin L-like protease	0.006	0.0383	0.1507
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0076	0.0053
Brugia malayi	Cathepsin L-like precursor	0.0011	0.004	0.0085
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0101	0.067	0.8702
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0032	0.0066
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0076	0.0161
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0016	0.0076	0.0053
Entamoeba histolytica	hypothetical protein	0.0034	0.0201	0.7175
Echinococcus granulosus	fatty acid binding protein FABP2	0.0042	0.0256	0.0233
Echinococcus granulosus	intermediate filament protein	0.0025	0.0143	0.012
Leishmania major	cysteine peptidase A (CPA)	0.0016	0.0076	0.0116
Leishmania major	cathepsin L-like protease	0.006	0.0383	0.1507
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.0383	0.1611
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0016	0.0076	0.2054
Echinococcus multilocularis	fatty acid binding protein FABP2	0.0042	0.0256	0.0233
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0061	0.0134
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0012	0.0052	0.0029
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0076	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0049	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0025	0.014	0.0315
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0026	0.0144	0.372
Schistosoma mansoni	transcription factor LCR-F1	0.0034	0.0201	0.0198
Loa Loa (eye worm)	fibroinase	0.0016	0.0076	0.0169
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0009	0.0032	0.0325
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.0383	0.1611
Plasmodium vivax	SET domain containing protein	0.0006	0.0011	0.0206
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0163	0.1098	0.1077
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.0383	0.1611
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0091	0.0597	0.0594
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0015	0.0074	0.0227
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0016	0.0076	0.0053
Brugia malayi	acetyltransferase, GNAT family protein	0.0168	0.113	0.2606
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0009	0.0032	0.0008
Leishmania major	cathepsin L-like protease	0.0016	0.0076	0.0116
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0015	0.0074	0.0105
Echinococcus multilocularis	lamin	0.0025	0.0143	0.012
Echinococcus multilocularis	microtubule associated protein 2	0.1447	1	1
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0015	0.0074	0.0051
Echinococcus granulosus	L aminoadipate semialdehyde	0.0091	0.0597	0.0575
Brugia malayi	hypothetical protein	0.0034	0.0201	0.0458
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0023	0.0829
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0023	0.0829
Trichomonas vaginalis	mercuric reductase, putative	0.0015	0.0074	0.0154
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0168	0.113	0.111
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0174	0.1171	1
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0076	0.0169
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.033	0.2254	1
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0026	0.0144	0.0641
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0076	0.0161
Plasmodium vivax	vivapain-3	0.0008	0.0023	0.0524
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0015	0.0074	0.0314
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0049	0.0309	0.7979
Entamoeba histolytica	cysteine proteinase, putative	0.0008	0.0023	0.0829
Echinococcus multilocularis	muscleblind protein	0.0163	0.1098	0.1077
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0076	0.011
Onchocerca volvulus		0.0016	0.0076	0.011
Brugia malayi	Pre-SET motif family protein	0.0061	0.0388	0.0889
Onchocerca volvulus		0.0025	0.0143	0.0315
Loa Loa (eye worm)	intermediate filament protein	0.0025	0.0143	0.0323
Onchocerca volvulus		0.0016	0.0076	0.011
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0076	0.0161
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0076	0.0161
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0025	0.0143	0.0323
Toxoplasma gondii	thioredoxin reductase	0.0044	0.0275	0.7098
Entamoeba histolytica	recQ family helicase, putative	0.0012	0.0051	0.1803
Schistosoma mansoni	DNA helicase recq1	0.0009	0.0032	0.0028
Brugia malayi	Bloom's syndrome protein homolog	0.0023	0.0123	0.0278
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0076	0.0161
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0012	0.0052	0.0029
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0015	0.0074	0.0314
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0076	0.2713
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0015	0.0074	0.0314
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0023	0.0829
Echinococcus granulosus	fatty acid binding protein FABP2	0.0042	0.0256	0.0233
Plasmodium falciparum	histone acetyltransferase GCN5	0.0045	0.0281	1
Trypanosoma cruzi	cysteine peptidase, putative	0.006	0.0383	0.1686
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0076	0.0161
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0023	0.0829
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0015	0.0074	0.1905
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0049	0.0309	0.7979
Schistosoma mansoni	blooms syndrome DNA helicase	0.0018	0.0091	0.0087
Schistosoma mansoni	hypothetical protein	0.0053	0.0332	0.0329
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0061	0.0388	0.0384
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0032	0.0817
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0076	0.0169
Trichomonas vaginalis	glutathione reductase, putative	0.0015	0.0074	0.0154
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0076	0.0161
Onchocerca volvulus		0.0016	0.0076	0.011
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0026	0.0144	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0143	0.0323
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0011	0.004	0.0085
Trypanosoma cruzi	cysteine peptidase, putative	0.006	0.0383	0.1686
Entamoeba histolytica	hypothetical protein	0.0034	0.0201	0.7175
Plasmodium vivax	vivapain-1	0.0008	0.0023	0.0524
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0076	0.0161
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0023	0.0829
Toxoplasma gondii	NADPH-glutathione reductase	0.0015	0.0074	0.1905
Schistosoma mansoni	survival motor neuron protein	0.0053	0.0332	0.0329
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0049	0.0309	0.0872
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0009	0.0032	0.0008
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0058	0.0372	0.035
Onchocerca volvulus		0.0053	0.0332	0.0895
Brugia malayi	Papain family cysteine protease containing protein	0.0008	0.0023	0.0047
Trypanosoma cruzi	major cysteine proteinase, putative	0.0047	0.0294	0.1291
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0076	0.0161
Schistosoma mansoni	fatty acid binding protein	0.0042	0.0256	0.0253
Echinococcus granulosus	cathepsin l1	0.0011	0.004	0.0017
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0023	0.0829
Plasmodium vivax	glutathione reductase, putative	0.0044	0.0275	0.7074
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0076	0.0161
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.0383	0.1611
Loa Loa (eye worm)	hypothetical protein	0.0163	0.1098	0.2531
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0008	0.0023	0.0089
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0061	0.0388	0.0384
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0053	0.0332	0.0761
Loa Loa (eye worm)	ctsf protein	0.0016	0.0076	0.0169
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0026	0.0144	0.372
Schistosoma mansoni	intermediate filament proteins	0.0025	0.0143	0.014
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0052	0.0113
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0008	0.0023	0.002
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0101	0.067	0.5427
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0015	0.0074	0.1693
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0049	0.0309	0.0287
Trypanosoma cruzi	cysteine peptidase, putative	0.0008	0.0023	0.0089
Echinococcus granulosus	lamin	0.0025	0.0143	0.012
Leishmania major	trypanothione reductase	0.0044	0.0275	0.1019
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.0383	0.1611
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0009	0.0032	0.0008
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0061	0.0388	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0076	0.0161
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0076	0.0169
Plasmodium vivax	vivapain-2	0.0016	0.0076	0.1899
Onchocerca volvulus		0.0016	0.0076	0.011
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0423	0.2898	0.6693
Mycobacterium ulcerans	hypothetical protein	0.0174	0.1171	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0076	0.0053
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0032	0.0066
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0016	0.0076	0.2054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.0383	0.1611
Onchocerca volvulus		0.0061	0.0388	0.1065
Trypanosoma brucei	hypothetical protein, conserved	0.0026	0.0144	0.0542
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0015	0.0074	0.0105
Plasmodium falciparum	thioredoxin reductase	0.0044	0.0275	0.978
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0076	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0754	0.1736
Entamoeba histolytica	cysteine proteinase, putative	0.0008	0.0023	0.0829
Echinococcus multilocularis	musashi	0.0025	0.0143	0.012
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0076	0.0161
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0026	0.0144	0.0641
Loa Loa (eye worm)	hypothetical protein	0.0258	0.1757	0.4056
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0061	0.0134
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0113	0.0748	0.6141
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0023	0.0829
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0049	0.0309	0.7963
Leishmania major	phosphopantetheinyl transferase-like protein	0.0026	0.0144	0.0424
Onchocerca volvulus	Cathepsin F homolog	0.0016	0.0076	0.011
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0015	0.0074	0.1838
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0034	0.0201	0.0179
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.0383	0.1611
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0009	0.0032	0.0066
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0156	0.1049	0.4533
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0076	0.0169
Trypanosoma cruzi	cysteine peptidase, putative	0.0016	0.0076	0.0324
Brugia malayi	Papain family cysteine protease containing protein	0.0008	0.0023	0.0047
Onchocerca volvulus		0.0016	0.0076	0.011
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0046	0.0289	0.1268
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0015	0.0074	0.1838
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0076	0.2713
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0015	0.0074	0.0105
Mycobacterium tuberculosis	Probable oxidoreductase	0.0113	0.0748	0.6141
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0012	0.0051	0.0123
Plasmodium falciparum	glutathione reductase	0.0044	0.0275	0.978
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0026	0.0144	0.3668
Leishmania major	cathepsin L-like protease	0.0016	0.0076	0.0116
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0016	0.0076	0.2054
Onchocerca volvulus		0.0481	0.3303	1
Entamoeba histolytica	cysteine proteinase, putative	0.0008	0.0023	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0049	0.0105
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0061	0.0388	0.0384
Leishmania major	cathepsin L-like protease	0.006	0.0383	0.1507
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0061	0.0388	0.0365
Schistosoma mansoni	fatty acid binding protein	0.0042	0.0256	0.0253
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.002	0.0104	0.3153
Trypanosoma cruzi	trypanothione reductase, putative	0.0015	0.0074	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0597	0.1372
Leishmania major	cathepsin L-like protease	0.0016	0.0076	0.0116
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0168	0.113	0.1128
Onchocerca volvulus		0.0025	0.0143	0.0315
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.0383	0.1611
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0026	0.0144	0.4695
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0101	0.067	0.5427
Loa Loa (eye worm)	acetyltransferase	0.0168	0.113	0.2606
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0076	0.0161
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0101	0.067	0.5427
Trypanosoma cruzi	cysteine peptidase, putative	0.006	0.0383	0.1686
Loa Loa (eye worm)	hypothetical protein	0.0011	0.004	0.0085
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0015	0.0074	0.1963
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0388	0.0889
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.0383	0.1611
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0015	0.0074	0.0163
Brugia malayi	Intermediate filament tail domain containing protein	0.0025	0.0143	0.0323
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0049	0.0309	0.0872
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0032	0.0066
Echinococcus multilocularis	bloom syndrome protein	0.0023	0.0123	0.01
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0076	0.0169
Brugia malayi	Muscleblind-like protein	0.0163	0.1098	0.2531
Plasmodium falciparum	glutathione reductase	0.0015	0.0074	0.1963
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0076	0.0161
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0076	0.0161
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0015	0.0072	0.1847
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0076	0.0169
Leishmania major	cathepsin L-like protease	0.0016	0.0076	0.0116
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0008	0.0023	0.002
Entamoeba histolytica	cysteine proteinase, putative	0.0011	0.004	0.1429
Leishmania major	cathepsin L-like protease	0.0016	0.0076	0.0116
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0032	0.0817
Brugia malayi	Cathepsin L-like precursor	0.0011	0.004	0.0085
Echinococcus multilocularis	fatty acid binding protein FABP2	0.0042	0.0256	0.0233
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0016	0.0076	0.0169
Entamoeba histolytica	hypothetical protein	0.0034	0.0201	0.7175
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0012	0.0051	0.0211
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0015	0.0074	0.0314
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0015	0.0074	0.0227
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0023	0.0829
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0015	0.0074	0.0314
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0076	0.011
Brugia malayi	Lipocalin / cytosolic fatty-acid binding protein family protein	0.0629	0.4328	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0061	0.0388	0.0365
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0015	0.0074	0.0227
Brugia malayi	Pre-SET motif family protein	0.0423	0.2898	0.6693
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0015	0.0074	0.0314
Schistosoma mansoni	microtubule-associated protein tau	0.1447	1	1
Trichomonas vaginalis	DNA helicase recq1, putative	0.0023	0.0123	0.0305
Echinococcus granulosus	survival motor neuron protein 1	0.0258	0.1757	0.1738
Plasmodium vivax	vivapain-2	0.0016	0.0076	0.1899
Giardia lamblia	Histone acetyltransferase GCN5	0.0045	0.0281	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.033	0.2254	1
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0015	0.0074	0.0071
Trypanosoma cruzi	cysteine proteinase, putative	0.0008	0.0023	0.0089
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.004	0.0051
Schistosoma mansoni	cathepsin F (C01 family)	0.0011	0.004	0.0037
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0026	0.0144	1
Trypanosoma cruzi	cysteine protease, putative	0.0008	0.0023	0.0089
Echinococcus granulosus	cathepsin l1	0.0016	0.0076	0.0053
Toxoplasma gondii	hypothetical protein	0.0053	0.0336	0.8668
Trichomonas vaginalis	set domain proteins, putative	0.0481	0.3303	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0113	0.0748	0.6141
Onchocerca volvulus		0.0091	0.0597	0.1705
Mycobacterium tuberculosis	Probable reductase	0.0101	0.067	0.5427
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0023	0.0829
Loa Loa (eye worm)	lipocalin/cytosolic fatty-acid binding protein family protein	0.0629	0.4328	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0113	0.0748	1
Echinococcus granulosus	muscleblind protein	0.0163	0.1098	0.1077
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0156	0.1049	0.4648
Brugia malayi	intermediate filament protein	0.0025	0.0143	0.0323

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 6.1 uM	In vitro inhibitory concentration against adipocyte fatty acid binding protein(A-FABP)	ChEMBL.	15357969
IC50 (binding)	= 6.1 uM	In vitro inhibitory concentration against adipocyte fatty acid binding protein(A-FABP)	ChEMBL.	15357969

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 323040