Detailed information for compound 328945

Basic information

Technical information
  • TDR Targets ID: 328945
  • Name: [2-amino-6-[2-(trifluoromethoxy)benzoyl]imida zo[1,2-a]pyridin-3-yl]-(2,6-difluorophenyl)me thanone
  • MW: 461.341 | Formula: C22H12F5N3O3
  • H donors: 1 H acceptors: 3 LogP: 6.37 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nc2n(c1C(=O)c1c(F)cccc1F)cc(cc2)C(=O)c1ccccc1OC(F)(F)F
  • InChi: 1S/C22H12F5N3O3/c23-13-5-3-6-14(24)17(13)20(32)18-21(28)29-16-9-8-11(10-30(16)18)19(31)12-4-1-2-7-15(12)33-22(25,26)27/h1-10H,28H2
  • InChiKey: QKSPSTLAHSVWOT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [2-amino-6-[oxo-[2-(trifluoromethoxy)phenyl]methyl]-3-imidazo[1,2-a]pyridinyl]-(2,6-difluorophenyl)methanone
  • [2-azanyl-6-[2-(trifluoromethoxy)phenyl]carbonyl-imidazo[1,2-a]pyridin-3-yl]-(2,6-difluorophenyl)methanone
  • [2-amino-6-[2-(trifluoromethoxy)benzoyl]imidazo[3,2-a]pyridin-3-yl]-(2,6-difluorophenyl)methanone
  • [2-amino-6-[oxo-[2-(trifluoromethoxy)phenyl]methyl]-3-imidazo[3,2-a]pyridinyl]-(2,6-difluorophenyl)methanone
  • [2-amino-6-[2-(trifluoromethoxy)phenyl]carbonyl-imidazo[3,2-a]pyridin-3-yl]-(2,6-difluorophenyl)methanone
  • aminoimidazo[1,2-a]pyridine deriv. 11

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin-dependent kinase 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.3091 0.7926 0.7926
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0251 0.0519 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.0735 0.1782 0.1781
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0251 0.0519 0.0518
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0735 0.1782 0.1781
Echinococcus multilocularis 0.0251 0.0519 0.0518
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0075 0.0061 0.006
Onchocerca volvulus 0.0251 0.0519 1
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0251 0.0519 0.0518
Leishmania major fk506-binding protein 1-like protein 0.0053 0.0005 0.0003
Echinococcus granulosus prolyl endopeptidase 0.0146 0.0245 0.0244
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0251 0.0519 0.0518
Trypanosoma cruzi target of rapamycin kinase 3 0.3094 0.7935 0.7934
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0053 0.0005 0.0005
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0251 0.0519 0.0518
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0058 0.0017 0.0015
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0251 0.0519 0.0518
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.3886 1 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0053 0.0005 0.0003
Giardia lamblia Hypothetical protein 0.0251 0.0519 0.0518
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.3886 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0251 0.0519 0.0518
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0251 0.0519 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.2322 0.5921 0.5921
Trichomonas vaginalis PIKK family atypical protein kinase 0.1303 0.3264 0.3263
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0146 0.0245 0.0244
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0251 0.0519 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3091 0.7926 0.7926
Trichomonas vaginalis PIKK family atypical protein kinase 0.1303 0.3264 0.3263
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1303 0.3264 0.3263
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0251 0.0519 0.0518
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0053 0.0005 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.1303 0.3264 0.3263
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0058 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0251 0.0519 0.0519
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0251 0.0519 0.0518
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0251 0.0519 0.0518
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1303 0.3264 0.3263
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0251 0.0519 0.0518
Trypanosoma cruzi prolyl endopeptidase 0.0146 0.0245 0.0244
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0053 0.0005 0.0003
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0251 0.0519 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.2523 0.6445 0.6444
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.3886 1 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.0001 0.0001
Schistosoma mansoni immunophilin 0.0053 0.0005 0.0003
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0251 0.0519 0.0518
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1303 0.3264 0.3263
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0053 0.0005 0.0003
Loa Loa (eye worm) phosphatidylinositol 3 0.3886 1 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0053 0.0005 0.0003
Entamoeba histolytica hypothetical protein 0.0251 0.0519 0.0518
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0053 0.0005 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.3091 0.7926 0.7926
Onchocerca volvulus 0.0251 0.0519 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1838 0.4658 0.4658
Loa Loa (eye worm) phosphatidylinositol 3 0.0251 0.0519 0.0519
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.3886 1 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0251 0.0519 0.0518
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0251 0.0519 0.0518
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0251 0.0519 1
Entamoeba histolytica hypothetical protein 0.0735 0.1782 0.1781
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0251 0.0519 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2098 0.5338 0.5337
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0519 0.0518
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0735 0.1782 0.1781
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0251 0.0519 0.0518
Loa Loa (eye worm) phosphatidylinositol 3 0.1303 0.3264 0.3264
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0053 0.0005 0.0003
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0251 0.0519 0.0518
Schistosoma mansoni immunophilin 0.0053 0.0005 0.0003
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0251 0.0519 0.0518
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.013 0.0206 0.3757
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0735 0.1782 0.1781
Loa Loa (eye worm) phosphatidylinositol 3 0.0251 0.0519 0.0519
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0251 0.0519 0.0518
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0735 0.1782 0.1781
Trichomonas vaginalis PIKK family atypical protein kinase 0.289 0.7403 0.7403
Echinococcus granulosus serine protein kinase ATM 0.0735 0.1782 0.1781
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1303 0.3264 0.3263
Echinococcus multilocularis prolyl endopeptidase 0.0146 0.0245 0.0244
Trichomonas vaginalis PIKK family atypical protein kinase 0.3091 0.7926 0.7926
Trichomonas vaginalis PIKK family atypical protein kinase 0.2098 0.5338 0.5337
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0251 0.0519 0.0518
Schistosoma mansoni hypothetical protein 0.0251 0.0519 0.0518
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0251 0.0519 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.2095 0.5329 0.5329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0735 0.1782 0.1781
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0568 0.1347 0.1346
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0251 0.0519 0.0518
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0058 0.0017 0.0015
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0053 0.0005 0.0003
Plasmodium vivax hypothetical protein, conserved 0.0251 0.0519 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0251 0.0519 0.0518
Trichomonas vaginalis immunophilin, putative 0.0053 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0065 0.0036 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.289 0.7403 0.7403
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0251 0.0519 0.0518
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0251 0.0519 0.0518
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0053 0.0005 0.5
Toxoplasma gondii target of rapamycin (TOR), putative 0.289 0.7403 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.289 0.7403 0.7403
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0251 0.0519 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0251 0.0519 0.0518
Loa Loa (eye worm) phosphatidylinositol 3 0.0251 0.0519 0.0519
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0251 0.0519 0.0518
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0251 0.0519 0.0518
Trypanosoma cruzi oligopeptidase b 0.0058 0.0017 0.0015
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0251 0.0519 0.0518
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0053 0.0005 0.0003
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0251 0.0519 0.0518
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0251 0.0519 0.0518
Loa Loa (eye worm) FKBP5 protein 0.0053 0.0005 0.0005
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0819 0.2001 0.2702
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.3886 1 1
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0058 0.0017 0.0015
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0735 0.1782 0.1781
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0251 0.0519 0.0518
Echinococcus multilocularis Zinc finger, PHD finger 0.0251 0.0519 0.0518
Leishmania major phosphatidylinositol kinase related protein, putative 0.0251 0.0519 0.0518
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0251 0.0519 0.0518
Brugia malayi FAT domain containing protein 0.0568 0.1347 0.1346
Trichomonas vaginalis conserved hypothetical protein 0.0819 0.2001 0.2
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.3886 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0075 0.0061 0.006
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0251 0.0519 0.0518
Brugia malayi prolyl oligopeptidase family protein 0.0146 0.0245 0.0244
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0251 0.0519 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.2607 0.6664 0.6663
Trichomonas vaginalis PIKK family atypical protein kinase 0.289 0.7403 0.7403
Schistosoma mansoni hypothetical protein 0.0568 0.1347 0.1346
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0053 0.0005 0.0003
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0251 0.0519 0.0518
Trypanosoma cruzi oligopeptidase b 0.0058 0.0017 0.0015
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0251 0.0519 0.0518
Echinococcus multilocularis fk506 binding protein 0.0053 0.0005 0.0003
Entamoeba histolytica hypothetical protein 0.0251 0.0519 0.0518
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0251 0.0519 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.289 0.7403 0.7403
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0053 0.0005 0.0003
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0251 0.0519 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.3886 1 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0251 0.0519 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.2098 0.5338 0.5337
Echinococcus multilocularis serine protein kinase ATM 0.0735 0.1782 0.1781
Entamoeba histolytica hypothetical protein 0.0251 0.0519 0.0518
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0251 0.0519 0.0518
Trypanosoma brucei prolyl oligopeptidase, putative 0.0058 0.0017 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.2095 0.5329 0.5329
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0251 0.0519 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.2299 0.5861 0.5861
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.007 0.0049 0.0047
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0251 0.0519 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0251 0.0519 0.0518
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0251 0.0519 0.0518
Loa Loa (eye worm) hypothetical protein 0.0484 0.1128 0.1128
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0251 0.0519 0.07
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0568 0.1347 0.1346
Trichomonas vaginalis PIKK family atypical protein kinase 0.2322 0.5921 0.5921
Loa Loa (eye worm) hypothetical protein 0.0819 0.2001 0.2001
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0053 0.0005 0.0003
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0146 0.0245 0.0244
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0519 0.0518
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0251 0.0519 0.07
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0053 0.0005 0.0003
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0053 0.0005 0.0003
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.0001 0.0001
Trichomonas vaginalis fk506-binding protein, putative 0.0053 0.0005 0.0003
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0735 0.1782 0.1781
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1303 0.3264 0.3263
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0058 0.0017 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1303 0.3264 0.3263
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0735 0.1782 0.1781
Trichomonas vaginalis PIKK family atypical protein kinase 0.1303 0.3264 0.3263
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0251 0.0519 1
Trypanosoma brucei oligopeptidase b 0.0058 0.0017 0.0015
Schistosoma mansoni fkbp-rapamycin associated protein 0.0735 0.1782 0.1781
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.3886 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0568 0.1347 0.1346
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0251 0.0519 0.0518
Schistosoma mansoni voltage-gated potassium channel 0.0082 0.0079 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.2299 0.5861 0.5861
Trichomonas vaginalis PIKK family atypical protein kinase 0.1043 0.2585 0.2584
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0251 0.0519 0.0518
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0146 0.0245 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0484 0.1128 0.1127
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0053 0.0005 0.0064
Loa Loa (eye worm) hypothetical protein 0.0792 0.1931 0.1931
Mycobacterium tuberculosis Conserved hypothetical protein 0.0251 0.0519 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0735 0.1782 0.1781
Loa Loa (eye worm) hypothetical protein 0.0251 0.0519 0.0519
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0251 0.0519 0.0518
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.007 0.0049 0.0047
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0251 0.0519 0.07
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0251 0.0519 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.3318 0.8518 0.8518
Leishmania major phosphatidylinositol 3-kinase, putative 0.1303 0.3264 0.3263
Loa Loa (eye worm) phosphatidylinositol 3 0.0251 0.0519 0.0519
Loa Loa (eye worm) phosphatidylinositol 3 0.0251 0.0519 0.0519
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.3886 1 1
Leishmania major phosphatidylinositol kinase, putative 0.0251 0.0519 0.0518
Giardia lamblia Phosphatidylinositol 4-kinase 0.0251 0.0519 0.0518
Plasmodium vivax hypothetical protein 0.0251 0.0519 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2098 0.5338 0.5337
Trichomonas vaginalis PIKK family atypical protein kinase 0.289 0.7403 0.7403
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0251 0.0519 0.0518
Toxoplasma gondii FATC domain-containing protein 0.0735 0.1782 0.2406
Loa Loa (eye worm) hypothetical protein 0.0568 0.1347 0.1347
Trichomonas vaginalis PIKK family atypical protein kinase 0.3091 0.7926 0.7926
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0251 0.0519 0.0518
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0251 0.0519 0.0518
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0251 0.0519 0.0518
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0251 0.0519 0.0518
Loa Loa (eye worm) hypothetical protein 0.0146 0.0245 0.0245
Schistosoma mansoni voltage-gated potassium channel 0.0082 0.0079 0.0078
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0251 0.0519 0.0518
Toxoplasma gondii prolyl endopeptidase 0.0146 0.0245 0.033
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0251 0.0519 0.07
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0735 0.1782 0.1781
Entamoeba histolytica hypothetical protein 0.0251 0.0519 0.0518
Leishmania major hypothetical protein, conserved 0.0251 0.0519 0.0518
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1303 0.3264 0.3263
Mycobacterium leprae conserved hypothetical protein 0.0251 0.0519 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0251 0.0519 0.0518
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.3886 1 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0053 0.0005 0.0003
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1303 0.3264 0.3263
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0251 0.0519 0.0518
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1614 0.4075 0.4074
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0251 0.0519 0.0518
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0251 0.0519 0.0518
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0052 0.0001 0.0001
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.3886 1 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0251 0.0519 0.0519
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0251 0.0519 0.0518
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1303 0.3264 0.3263
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0053 0.0005 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.3886 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0484 0.1128 0.1127
Leishmania major phosphatidylinositol 4-kinase, putative 0.0251 0.0519 0.0518
Leishmania major oligopeptidase b 0.0058 0.0017 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.2095 0.5329 0.5329
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0251 0.0519 0.07
Trichomonas vaginalis PIKK family atypical protein kinase 0.2322 0.5921 0.5921
Trichomonas vaginalis PIKK family atypical protein kinase 0.0735 0.1782 0.1781
Loa Loa (eye worm) phosphatidylinositol kinase 0.0251 0.0519 0.0519
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1303 0.3264 0.3263
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0251 0.0519 0.0518
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0251 0.0519 0.0518
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.3886 1 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0484 0.1128 0.1127
Leishmania major phosphatidylinositol 3-kinase, putative 0.0251 0.0519 0.0518
Entamoeba histolytica protein kinase rad3, putative 0.0735 0.1782 0.1781
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.3094 0.7935 0.7934
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0053 0.0005 0.0003
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0075 0.0061 0.0061
Trypanosoma brucei prolyl endopeptidase 0.0146 0.0245 0.0244
Trichomonas vaginalis PIKK family atypical protein kinase 0.3886 1 1
Giardia lamblia GTOR 0.3886 1 1
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0251 0.0519 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0251 0.0519 0.0518
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0251 0.0519 0.0518
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0053 0.0005 0.0003
Leishmania major hypothetical protein, unknown function 0.0251 0.0519 0.0518
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0251 0.0519 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.289 0.7403 0.7403
Leishmania major peptidylprolyl isomerase-like protein 0.0053 0.0005 0.0003
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0053 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0735 0.1782 0.1782
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0251 0.0519 0.0518
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0075 0.0061 0.006
Trypanosoma brucei target of rapamycin kinase 3, putative 0.3094 0.7935 0.7934

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2171 nM Inhibitory activity against Cyclin-dependent kinase 2 (CDK2) ChEMBL. 15546737
IC50 (binding) = 2171 nM Inhibitory activity against Cyclin-dependent kinase 2 (CDK2) ChEMBL. 15546737

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.