Detailed information for compound 329134

Basic information

Technical information
  • TDR Targets ID: 329134
  • Name: N-(3,4-difluorophenyl)-4-pyrazolo[5,1-f]pyrid azin-3-ylpyrimidin-2-amine
  • MW: 324.288 | Formula: C16H10F2N6
  • H donors: 1 H acceptors: 4 LogP: 2.65 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1F)Nc1nccc(n1)c1cnn2c1cccn2
  • InChi: 1S/C16H10F2N6/c17-12-4-3-10(8-13(12)18)22-16-19-7-5-14(23-16)11-9-21-24-15(11)2-1-6-20-24/h1-9H,(H,19,22,23)
  • InChiKey: BLZGDFUGFILBJG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3,4-difluorophenyl)-4-pyrazolo[5,1-f]pyridazin-3-yl-pyrimidin-2-amine
  • N-(3,4-difluorophenyl)-4-(3-pyrazolo[5,1-f]pyridazinyl)-2-pyrimidinamine
  • (3,4-difluorophenyl)-(4-pyrazolo[5,1-f]pyridazin-3-ylpyrimidin-2-yl)amine
  • pyrazolo[1,5-b]pyridazine deriv. 28

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0198 0.1592 0.1592
Chlamydia trachomatis AMP nucleosidase 0.02 0.1614 0.5
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0967 1 1
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.02 0.1614 0.1614
Echinococcus multilocularis purine nucleoside phosphorylase 0.0967 1 1
Trichomonas vaginalis hypoxanthine-guanine phosphoribosyltransferase, putative 0.0198 0.1592 0.1592
Entamoeba histolytica hypothetical protein 0.02 0.1614 1
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0059 0.0065 0.0065
Leishmania major xanthine phosphoribosyltransferase 0.0198 0.1592 0.9865
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.02 0.1614 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.0967 1 1
Trypanosoma cruzi nucleoside phosphorylase, putative 0.02 0.1614 1
Echinococcus granulosus uridine phosphorylase 1 0.02 0.1614 0.1614
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0059 0.0065 0.0401
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0065 0.0401
Mycobacterium leprae probable uridine phosphorylase 0.02 0.1614 0.0594
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0198 0.1592 0.1592
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.0767 0.781 0.781
Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase 0.0198 0.1592 0.9865
Echinococcus multilocularis purine nucleoside phosphorylase 0.0967 1 1
Schistosoma mansoni methylthioadenosine phosphorylase 0.02 0.1614 0.1614
Schistosoma mansoni uridine phosphorylase 0.02 0.1614 0.1614
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.02 0.1614 0.1614
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase, putative 0.0198 0.1592 0.9865
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.02 0.1614 0.1614
Echinococcus multilocularis purine nucleoside phosphorylase 0.0967 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0065 0.0065
Echinococcus granulosus purine nucleoside phosphorylase 0.0967 1 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.0767 0.781 0.781
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.02 0.1614 1
Echinococcus granulosus methylthioadenosine phosphorylase 0.02 0.1614 0.1614
Echinococcus multilocularis protein kinase shaggy 0.0059 0.0065 0.0065
Echinococcus granulosus purine nucleoside phosphorylase 0.0967 1 1
Loa Loa (eye worm) uridine phosphorylase 0.02 0.1614 0.2067
Onchocerca volvulus 0.0198 0.1592 0.1538
Leishmania major methylthioadenosine phosphorylase, putative 0.02 0.1614 1
Plasmodium falciparum glycogen synthase kinase 3 0.0059 0.0065 0.0401
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0198 0.1592 0.9865
Echinococcus granulosus purine nucleoside phosphorylase 0.0967 1 1
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.0967 1 1
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.02 0.1614 0.0026
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.02 0.1614 1
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0198 0.1592 0.9865
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0059 0.0065 0.0065
Echinococcus granulosus purine nucleoside phosphorylase 0.0967 1 1
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0198 0.1592 0.1592
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0065 0.0401
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.02 0.1614 0.1614
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.02 0.1614 0.0026
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.02 0.1614 1
Giardia lamblia Kinase, CMGC GSK 0.0059 0.0065 0.0065
Echinococcus multilocularis purine nucleoside phosphorylase 0.0967 1 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.0065 0.0083
Echinococcus granulosus purine nucleoside phosphorylase 0.0967 1 1
Giardia lamblia Guanine phosphoribosyltransferase 0.0198 0.1592 0.1592
Leishmania major hypoxanthine-guanine phosphoribosyltransferase 0.0198 0.1592 0.9865
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.02 0.1614 0.1614
Schistosoma mansoni purine nucleoside phosphorylase 0.0967 1 1
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0198 0.1592 0.9865
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.0065 0.0083
Mycobacterium tuberculosis Hypothetical protein 0.02 0.1614 0.0594
Trichomonas vaginalis conserved hypothetical protein 0.02 0.1614 0.1614
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.02 0.1614 0.0594
Trichomonas vaginalis conserved hypothetical protein 0.02 0.1614 0.1614
Entamoeba histolytica protein kinase, putative 0.0059 0.0065 0.0401
Echinococcus granulosus purine nucleoside phosphorylase 0.0967 1 1
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0198 0.1592 0.1592
Treponema pallidum pfs protein (pfs) 0.02 0.1614 0.5
Brugia malayi intracellular kinase 0.0059 0.0065 0.0065
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0198 0.1592 0.9865
Trypanosoma brucei uridine phosphorylase 0.02 0.1614 1
Toxoplasma gondii Purine nucleoside phosphorylase 0.02 0.1614 1
Plasmodium vivax glycogen synthase kinase 3, putative 0.0059 0.0065 0.0401
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.02 0.1614 1
Brugia malayi Phosphoribosyl transferase domain containing protein 0.0198 0.1592 0.1592
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase, putative 0.0198 0.1592 0.9865
Giardia lamblia Kinase, CMGC GSK 0.0059 0.0065 0.0065
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.02 0.1614 0.2067
Mycobacterium tuberculosis Conserved hypothetical protein 0.02 0.1614 0.0594
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0967 1 1
Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT 0.0198 0.1592 0.9865
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0059 0.0065 0.0401
Trypanosoma cruzi nucleoside phosphorylase, putative 0.02 0.1614 1
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0059 0.0065 0.0401
Giardia lamblia UPL-1 0.02 0.1614 0.1614
Trypanosoma cruzi nucleoside phosphorylase, putative 0.02 0.1614 1
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0198 0.1592 0.1592
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0198 0.1592 0.9865
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.02 0.1614 0.1614
Echinococcus multilocularis purine nucleoside phosphorylase 0.0967 1 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.0767 0.781 0.781
Echinococcus multilocularis uridine phosphorylase 1 0.02 0.1614 0.1614
Toxoplasma gondii phosphorylase family protein 0.02 0.1614 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.02 0.1614 0.1614
Leishmania major nucleoside phosphorylase-like protein 0.02 0.1614 1
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0198 0.1592 0.1592
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.02 0.1614 0.5
Trypanosoma brucei protein kinase, putative 0.0059 0.0065 0.0401
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.02 0.1614 1
Echinococcus granulosus purine nucleoside phosphorylase 0.0967 1 1
Schistosoma mansoni methylthioadenosine phosphorylase 0.02 0.1614 0.1614
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0198 0.1592 0.9865
Brugia malayi uridine phosphorylase family protein 0.02 0.1614 0.1614
Toxoplasma gondii phosphorylase family protein 0.02 0.1614 1
Echinococcus granulosus purine nucleoside phosphorylase 0.0967 1 1
Echinococcus multilocularis methylthioadenosine phosphorylase 0.02 0.1614 0.1614
Schistosoma mansoni purine nucleoside phosphorylase 0.0967 1 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.02 0.1614 0.1614
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0967 1 1
Mycobacterium ulcerans purine nucleoside phosphorylase 0.0967 1 1
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0967 1 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.02 0.1614 0.1614
Schistosoma mansoni uridine phosphorylase 0.02 0.1614 0.1614
Plasmodium vivax purine nucleoside phosphorylase, putative 0.02 0.1614 1
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.02 0.1614 1
Treponema pallidum uridine phosphorylase (udp) 0.02 0.1614 0.5
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.02 0.1614 1
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0059 0.0065 0.0065
Schistosoma mansoni methylthioadenosine phosphorylase 0.02 0.1614 0.1614
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0767 0.781 1
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.02 0.1614 1
Plasmodium falciparum purine nucleoside phosphorylase 0.02 0.1614 1
Echinococcus granulosus protein kinase shaggy 0.0059 0.0065 0.0065
Brugia malayi MTAP 0.02 0.1614 0.1614

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) uM Binding affinity for human cyclin-dependent kinase 4; ND= Not determined ChEMBL. 15341487
Ki (binding) 0 uM Binding affinity for human cyclin-dependent kinase 4; ND= Not determined ChEMBL. 15341487
Ki (binding) = 0.002 uM Binding affinity for human cyclin-dependent kinase 2 ChEMBL. 15341487
Ki (binding) = 0.002 uM Binding affinity for human cyclin-dependent kinase 2 ChEMBL. 15341487
Ki (binding) = 0.01 uM Binding affinity for human glycogen synthase kinase 3 beta ChEMBL. 15341487
Ki (binding) = 0.01 uM Binding affinity for human glycogen synthase kinase 3 beta ChEMBL. 15341487

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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