TDR Targets

Basic information

Technical information

TDR Targets ID: 337540
Name: (Z)-2-benzamido-3-[4-(2-methylphenoxy)phenyl] prop-2-enoic acid
MW: 373.401 | Formula: C23H19NO4
H donors: 2 H acceptors: 3 LogP: 4.81 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)/C(=C/c1ccc(cc1)Oc1ccccc1C)/NC(=O)c1ccccc1
InChi: 1S/C23H19NO4/c1-16-7-5-6-10-21(16)28-19-13-11-17(12-14-19)15-20(23(26)27)24-22(25)18-8-3-2-4-9-18/h2-15H,1H3,(H,24,25)(H,26,27)/b20-15-
InChiKey: KCCUFQLLLSRATN-HKWRFOASSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(Z)-2-benzamido-3-[4-(2-methylphenoxy)phenyl]-2-propenoic acid
(Z)-2-benzamido-3-[4-(2-methylphenoxy)phenyl]acrylic acid
AIDS-326361
AIDS326361
2-Benzoylamino-3-(4-o-tolyloxy-phenyl)-acrylic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Hepatitis C virus	Hepatitis C virus NS5B RNA-dependent RNA polymerase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	DNA helicase	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma brucei gambiense	DNA repair and recombination helicase protein PIF1, putative,DNA repair and recombination protein, mitochondrial precursor, puta	Get druggable targets OG5_128192	All targets in OG5_128192
Entamoeba histolytica	hypothetical protein, conserved	Get druggable targets OG5_128192	All targets in OG5_128192
Schistosoma japonicum	ko:K01529 PIF1 5'-to-3' DNA helicase [EC:3.6.1.-], putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_128192	All targets in OG5_128192
Candida albicans	similar to PIF1 DNA helicase	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania donovani	PIF1 helicase-like protein, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma brucei	DNA repair and recombination helicase protein PIF7	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma brucei	DNA repair and recombination helicase protein PIF6	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania mexicana	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma congolense	DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania mexicana	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma brucei gambiense	DNA repair and recombination helicase protein PIF1, putative,DNA repair and recombination protein, mitochondrial precursor, puta	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF6, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania donovani	PIF1 helicase-like protein, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania braziliensis	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Entamoeba histolytica	DNA repair and recombination protein, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania infantum	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma congolense	DNA repair and recombination helicase protein PIF6	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Echinococcus multilocularis	ATP dependent DNA helicase PIF1	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania braziliensis	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Candida albicans	similar to putative DNA helicase involved in repair and recombination of mitochondrial DNA that also plays a role in (nuclear) c	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania infantum	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Giardia lamblia	Rrm3p helicase	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Echinococcus granulosus	ATP dependent DNA helicase PIF1	Get druggable targets OG5_128192	All targets in OG5_128192

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	tubulin beta chain, putative	0.007	0.2557	0.2648
Leishmania major	alpha tubulin	0.007	0.2557	0.3361
Leishmania major	alpha tubulin	0.007	0.2557	0.3361
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.1211	0.1592
Leishmania major	beta tubulin	0.0179	0.7609	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.007	0.2557	0.3361
Echinococcus multilocularis	Tubulin beta 2C chain	0.0179	0.7609	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0039	0.1161	0.0616
Brugia malayi	Tubulin beta-1 chain	0.0179	0.7609	0.7609
Mycobacterium ulcerans	DNA polymerase IV	0.0041	0.1211	1
Entamoeba histolytica	DNA repair and recombination protein, putative	0.0034	0.0889	0.1168
Schistosoma mansoni	alpha tubulin	0.007	0.2557	0.3361
Toxoplasma gondii	alpha-tubulin I, putative	0.007	0.2557	0.2648
Trichomonas vaginalis	tubulin alpha chain, putative	0.0039	0.1161	0.0616
Echinococcus granulosus	tubulin gamma 1 chain	0.007	0.2557	0.3361
Echinococcus granulosus	tubulin alpha 1C chain	0.007	0.2557	0.3361
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0231	1	1
Leishmania major	beta tubulin	0.0179	0.7609	1
Trypanosoma brucei	epsilon tubulin	0.007	0.2557	0.3361
Loa Loa (eye worm)	tubulin beta chain	0.003	0.0737	0.0737
Leishmania major	alpha tubulin	0.007	0.2557	0.3361
Loa Loa (eye worm)	alpha-tubulin	0.007	0.2557	0.2557
Trypanosoma brucei	cytochrome P450, putative	0.0016	0.0062	0.0082
Brugia malayi	Cytochrome P450 family protein	0.0016	0.0062	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0757	0.0757
Trypanosoma brucei	tubulin gamma chain	0.007	0.2557	0.3361
Leishmania major	alpha tubulin	0.007	0.2557	0.3361
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1161	0.1161
Loa Loa (eye worm)	tubulin alpha 2	0.0039	0.1161	0.1161
Loa Loa (eye worm)	hypothetical protein	0.003	0.0737	0.0737
Plasmodium falciparum	tubulin gamma chain	0.007	0.2557	0.2648
Trypanosoma brucei	epsilon tubulin	0.007	0.2557	0.3361
Leishmania major	alpha tubulin	0.007	0.2557	0.3361
Echinococcus multilocularis	Tubulin beta 2C chain	0.0179	0.7609	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0179	0.7609	1
Leishmania major	beta tubulin	0.0179	0.7609	1
Trypanosoma brucei	beta tubulin	0.0179	0.7609	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.007	0.2557	0.3361
Echinococcus granulosus	tubulin delta chain	0.003	0.0737	0.0969
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.1211	0.1592
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0179	0.7609	1
Echinococcus multilocularis	tubulin alpha chain	0.007	0.2557	0.3361
Plasmodium vivax	tubulin gamma chain, putative	0.007	0.2557	0.2648
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0039	0.1161	0.0616
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0096	0.0126
Loa Loa (eye worm)	tubulin alpha chain	0.007	0.2557	0.2557
Giardia lamblia	Alpha-tubulin	0.007	0.2557	0.3088
Trypanosoma brucei	zeta tubulin, putative	0.003	0.0737	0.0969
Trichomonas vaginalis	tubulin, putative	0.0039	0.1161	0.0616
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0.0301	0.4077
Entamoeba histolytica	tubulin family protein	0.0179	0.7609	1
Schistosoma mansoni	tubulin subunit alpha	0.007	0.2557	0.3361
Trypanosoma brucei	zeta tubulin	0.003	0.0737	0.0969
Loa Loa (eye worm)	tubulin beta-1 chain	0.0179	0.7609	0.7609
Echinococcus multilocularis	Tubulin alpha 1 chain	0.007	0.2557	0.3361
Entamoeba histolytica	hypothetical protein, conserved	0.0034	0.0889	0.1168
Trypanosoma brucei	DNA repair and recombination helicase protein PIF7	0.0034	0.0889	0.1168
Echinococcus granulosus	tubulin subunit TubB	0.007	0.2557	0.3361
Trichomonas vaginalis	tubulin epsilon chain, putative	0.007	0.2557	0.2648
Giardia lamblia	Alpha-tubulin	0.007	0.2557	0.3088
Brugia malayi	Tubulin beta chain	0.0039	0.1161	0.1161
Leishmania major	DNA polymerase kappa, putative	0.0021	0.0301	0.0395
Echinococcus granulosus	Tubulin beta 2C chain	0.0179	0.7609	1
Echinococcus granulosus	dna polymerase kappa	0.0041	0.1211	0.1592
Echinococcus multilocularis	tubulin epsilon chain	0.007	0.2557	0.3361
Loa Loa (eye worm)	beta-tubulin	0.0179	0.7609	0.7609
Plasmodium vivax	tubulin beta chain, putative	0.0179	0.7609	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.007	0.2557	0.3361
Plasmodium falciparum	tubulin beta chain	0.0179	0.7609	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0179	0.7609	1
Schistosoma mansoni	tubulin subunit beta	0.0179	0.7609	1
Brugia malayi	Tubulin alpha-2 chain	0.007	0.2557	0.2557
Trypanosoma cruzi	tubulin delta chain	0.003	0.0737	0.0969
Giardia lamblia	Beta tubulin	0.0179	0.7609	1
Echinococcus granulosus	tubulin alpha chain	0.007	0.2557	0.3361
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.1211	0.1592
Leishmania major	alpha tubulin	0.007	0.2557	0.3361
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0889	0.0221
Giardia lamblia	Delta tubulin	0.003	0.0737	0.0597
Echinococcus multilocularis	beta tubulin	0.0179	0.7609	1
Mycobacterium ulcerans	DNA polymerase IV	0.0041	0.1211	1
Echinococcus granulosus	tubulin beta 1 chain	0.0179	0.7609	1
Schistosoma mansoni	tubulin subunit alpha	0.007	0.2557	0.3361
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0034	0.0889	0.1168
Entamoeba histolytica	tubulin alpha-1 chain	0.007	0.2557	0.3361
Echinococcus multilocularis	Tubulin beta 2C chain	0.0179	0.7609	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0031	0.0757	0.0994
Echinococcus multilocularis	Tubulin beta 2C chain	0.0179	0.7609	1
Leishmania major	alpha tubulin	0.007	0.2557	0.3361
Giardia lamblia	Beta tubulin	0.0179	0.7609	1
Trypanosoma cruzi	epsilon tubulin, putative	0.007	0.2557	0.3361
Trichomonas vaginalis	tubulin alpha chain, putative	0.0039	0.1161	0.0616
Echinococcus multilocularis	tubulin alpha	0.007	0.2557	0.3361
Leishmania major	beta tubulin	0.0179	0.7609	1
Loa Loa (eye worm)	CYP4Cod1	0.0016	0.0062	0.0062
Loa Loa (eye worm)	tubulin beta-2A chain	0.0179	0.7609	0.7609
Echinococcus granulosus	tubulin alpha chain	0.007	0.2557	0.3361
Loa Loa (eye worm)	tubulin alpha chain	0.007	0.2557	0.2557
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF6, putative	0.0034	0.0889	0.1168
Loa Loa (eye worm)	alpha-tubulin	0.007	0.2557	0.2557
Echinococcus granulosus	tubulin subunit beta	0.0179	0.7609	1
Leishmania major	epsilon tubulin, putative	0.007	0.2557	0.3361
Schistosoma mansoni	tubulin subunit delta	0.003	0.0737	0.0969
Toxoplasma gondii	beta tubulin	0.0179	0.7609	1
Trypanosoma brucei	beta tubulin	0.007	0.2557	0.3361
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0179	0.7609	1
Leishmania major	alpha tubulin	0.007	0.2557	0.3361
Toxoplasma gondii	beta-tubulin, putative	0.0179	0.7609	1
Trypanosoma brucei	unspecified product	0.0034	0.0911	0.1197
Plasmodium vivax	tubulin alpha chain, putative	0.007	0.2557	0.2648
Echinococcus multilocularis	tubulin subunit TubB	0.007	0.2557	0.3361
Leishmania major	beta tubulin	0.0179	0.7609	1
Trichomonas vaginalis	tubulin beta chain, putative	0.007	0.2557	0.2648
Trypanosoma brucei	epsilon tubulin	0.007	0.2557	0.3361
Loa Loa (eye worm)	cytochrome P450 family protein	0.0016	0.0062	0.0062
Schistosoma mansoni	tubulin subunit beta	0.0179	0.7609	1
Echinococcus multilocularis	ATP dependent DNA helicase PIF1	0.0034	0.0889	0.1168
Onchocerca volvulus		0.0039	0.1161	0.5
Leishmania major	beta tubulin	0.0179	0.7609	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.007	0.2557	0.2648
Schistosoma mansoni	alpha tubulin	0.007	0.2557	0.3361
Brugia malayi	tubulin alpha chain - mouse	0.007	0.2557	0.2557
Schistosoma mansoni	hypothetical protein	0.0034	0.0889	0.1168
Echinococcus multilocularis	tubulin alpha chain	0.007	0.2557	0.3361
Trypanosoma cruzi	cytochrome P450, putative	0.0016	0.0062	0.0082
Plasmodium falciparum	alpha tubulin 2	0.007	0.2557	0.2648
Trypanosoma brucei	tubulin delta chain	0.003	0.0737	0.0969
Brugia malayi	tubulin alpha-2 chain	0.007	0.2557	0.2557
Loa Loa (eye worm)	tubulin beta-4 chain	0.0179	0.7609	0.7609
Echinococcus multilocularis	tubulin subunit beta	0.0179	0.7609	1
Trichomonas vaginalis	tubulin beta chain, putative	0.007	0.2557	0.2648
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.1211	0.1592
Leishmania major	beta tubulin	0.0179	0.7609	1
Toxoplasma gondii	beta-1 tubulin, putative	0.0179	0.7609	1
Brugia malayi	Cytochrome P450 family protein	0.0016	0.0062	0.0062
Leishmania major	beta tubulin	0.0179	0.7609	1
Loa Loa (eye worm)	tubulin alpha-3 chain	0.003	0.0737	0.0737
Echinococcus granulosus	Tubulin alpha 1 chain	0.007	0.2557	0.3361
Schistosoma mansoni	tubulin subunit beta	0.0179	0.7609	1
Toxoplasma gondii	alpha tubulin TUBA1	0.007	0.2557	0.2648
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0034	0.0889	0.1168
Echinococcus multilocularis	tubulin beta 1 chain	0.0179	0.7609	1
Echinococcus granulosus	tubulin alpha 3 chain	0.007	0.2557	0.3361
Trypanosoma cruzi	tubulin delta chain	0.003	0.0737	0.0969
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.1211	0.1592
Trichomonas vaginalis	tubulin beta chain, putative	0.007	0.2557	0.2648
Plasmodium vivax	tubulin alpha chain, putative	0.007	0.2557	0.2648
Brugia malayi	Tubulin beta chain	0.003	0.0737	0.0737
Schistosoma mansoni	tubulin subunit beta	0.0179	0.7609	1
Leishmania major	alpha tubulin	0.007	0.2557	0.3361
Leishmania major	beta tubulin	0.0179	0.7609	1
Echinococcus granulosus	tubulin epsilon chain	0.007	0.2557	0.3361
Echinococcus granulosus	tubulin alpha chain	0.007	0.2557	0.3361
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0039	0.1161	0.0616
Echinococcus granulosus	beta tubulin	0.0179	0.7609	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0096	0.0126
Trichomonas vaginalis	tubulin, putative	0.0039	0.1161	0.0616
Leishmania major	beta tubulin	0.0179	0.7609	1
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0034	0.0889	0.1168
Echinococcus multilocularis	tubulin alpha chain	0.007	0.2557	0.3361
Plasmodium vivax	tubulin epsilon chain, putative	0.007	0.2557	0.2648
Trypanosoma brucei	DNA repair and recombination helicase protein PIF6	0.0034	0.0889	0.1168
Echinococcus multilocularis	tubulin alpha 1C chain	0.007	0.2557	0.3361
Trichomonas vaginalis	tubulin gamma chain, putative	0.007	0.2557	0.2648
Trypanosoma cruzi	cytochrome P450, putative	0.0016	0.0062	0.0082
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0039	0.1161	0.1161
Echinococcus multilocularis	Tubulin beta 2C chain	0.0179	0.7609	1
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.003	0.0737	0.5
Echinococcus granulosus	tubulin alpha chain	0.007	0.2557	0.3361
Echinococcus granulosus	Tubulin beta 2C chain	0.0179	0.7609	1
Trypanosoma brucei	beta tubulin	0.0179	0.7609	1
Schistosoma mansoni	tubulin subunit epsilon	0.007	0.2557	0.3361
Brugia malayi	alpha-tubulin	0.007	0.2557	0.2557
Echinococcus granulosus	alpha tubulin	0.007	0.2557	0.3361
Leishmania major	alpha tubulin	0.007	0.2557	0.3361
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.007	0.2557	0.2648
Echinococcus multilocularis	Tubulin alpha 1 chain	0.007	0.2557	0.3361
Leishmania major	delta tubulin, putative	0.003	0.0737	0.0969
Echinococcus granulosus	tubulin alpha	0.007	0.2557	0.3361
Plasmodium falciparum	alpha tubulin 1	0.007	0.2557	0.2648
Leishmania major	gamma-tubulin	0.007	0.2557	0.3361
Leishmania major	beta tubulin	0.0179	0.7609	1
Trypanosoma cruzi	zeta tubulin, putative	0.003	0.0737	0.0969
Trypanosoma brucei	alpha tubulin	0.007	0.2557	0.3361
Echinococcus granulosus	Tubulin beta 2C chain	0.0179	0.7609	1
Trichomonas vaginalis	tubulin beta chain, putative	0.007	0.2557	0.2648
Loa Loa (eye worm)	tubulin alpha 2	0.0039	0.1161	0.1161
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0034	0.0889	0.1168
Leishmania major	alpha tubulin	0.007	0.2557	0.3361
Leishmania major	cytochrome p450-like protein	0.0016	0.0062	0.0082
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0041	0.1211	0.069
Trichomonas vaginalis	tubulin alpha chain, putative	0.0179	0.7609	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0041	0.1211	0.1592
Leishmania major	beta tubulin	0.0179	0.7609	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.007	0.2557	0.2648
Treponema pallidum	cell division protein FtsZ	0.003	0.0737	0.5
Leishmania major	beta tubulin	0.0179	0.7609	1
Trypanosoma brucei	beta tubulin	0.0179	0.7609	1
Echinococcus multilocularis	tubulin delta chain	0.003	0.0737	0.0969
Echinococcus granulosus	Tubulin beta 2C chain	0.0179	0.7609	1
Echinococcus granulosus	peroxisome assembly protein 26	0.007	0.2557	0.3361
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0179	0.7609	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.2557	0.2557
Schistosoma mansoni	tubulin subunit gamma	0.007	0.2557	0.3361
Leishmania major	beta tubulin	0.0179	0.7609	1
Echinococcus multilocularis	hypothetical protein	0.007	0.2557	0.3361
Trichomonas vaginalis	tubulin gamma chain, putative	0.007	0.2557	0.2648
Trichomonas vaginalis	tubulin beta chain, putative	0.0039	0.1161	0.0616
Echinococcus granulosus	tubulin beta 4A class IVa	0.0179	0.7609	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.1211	0.1592
Leishmania major	beta tubulin	0.0179	0.7609	1
Mycobacterium tuberculosis	Cell division protein FtsZ	0.003	0.0737	1
Trypanosoma brucei	alpha tubulin	0.007	0.2557	0.3361
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.1211	0.1592
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.1211	0.1592
Trypanosoma cruzi	zeta tubulin, putative	0.003	0.0737	0.0969
Echinococcus granulosus	tubulin alpha 3 chain	0.007	0.2557	0.3361
Trypanosoma cruzi	beta tubulin, putative	0.0179	0.7609	1
Schistosoma mansoni	tubulin subunit beta	0.0179	0.7609	1
Giardia lamblia	Rrm3p helicase	0.0034	0.0889	0.0805
Brugia malayi	Tubulin gamma chain	0.007	0.2557	0.2557
Echinococcus granulosus	beta tubulin	0.0179	0.7609	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.1211	0.1592
Giardia lamblia	Gamma tubulin	0.007	0.2557	0.3088
Giardia lamblia	Beta tubulin	0.0179	0.7609	1
Trichomonas vaginalis	tubulin, putative	0.0179	0.7609	1
Brugia malayi	polk-prov protein	0.0031	0.0757	0.0757
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0096	0.0126
Trypanosoma brucei	DNA polymerase IV, putative	0.0034	0.0911	0.1197
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.1211	0.1592
Trichomonas vaginalis	tubulin alpha chain, putative	0.007	0.2557	0.2648
Trypanosoma brucei	alpha tubulin	0.007	0.2557	0.3361
Echinococcus multilocularis	tubulin alpha chain	0.007	0.2557	0.3361
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.1211	0.1592
Echinococcus multilocularis	tubulin gamma 1 chain	0.007	0.2557	0.3361
Trypanosoma brucei	beta tubulin	0.0179	0.7609	1
Echinococcus multilocularis	tubulin alpha chain	0.007	0.2557	0.3361
Trichomonas vaginalis	tubulin beta chain, putative	0.007	0.2557	0.2648
Leishmania major	beta tubulin	0.0179	0.7609	1
Schistosoma mansoni	tubulin subunit alpha	0.003	0.0737	0.0969
Schistosoma mansoni	tubulin subunit beta	0.0179	0.7609	1
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0021	0.0301	0.0395
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0301	0.0395
Echinococcus multilocularis	dna polymerase kappa	0.0041	0.1211	0.1592
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.1211	0.1592
Brugia malayi	Cell division protein ftsZ	0.003	0.0737	0.0737
Leishmania major	zeta tubulin, putative	0.003	0.0737	0.0969
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.1211	0.1592
Mycobacterium ulcerans	cell division protein FtsZ	0.003	0.0737	0.5874
Schistosoma mansoni	tubulin subunit beta	0.003	0.0737	0.0969
Loa Loa (eye worm)	BEN-1 protein	0.0179	0.7609	0.7609
Loa Loa (eye worm)	tubulin beta chain	0.0179	0.7609	0.7609
Leishmania major	alpha tubulin	0.007	0.2557	0.3361
Echinococcus multilocularis	tubulin alpha 1C chain	0.007	0.2557	0.3361
Echinococcus granulosus	tubulin alpha 1C chain	0.007	0.2557	0.3361
Loa Loa (eye worm)	BEN-1 protein	0.0179	0.7609	0.7609
Brugia malayi	Tubulin alpha chain	0.003	0.0737	0.0737
Entamoeba histolytica	tubulin alpha chain, putative	0.007	0.2557	0.3361
Brugia malayi	beta-tubulin, identical	0.0179	0.7609	0.7609
Trypanosoma brucei	DNA polymerase kappa, putative	0.0031	0.0757	0.0994
Entamoeba histolytica	tubulin family protein	0.0179	0.7609	1
Echinococcus multilocularis	beta tubulin	0.0179	0.7609	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.007	0.2557	0.3361
Trichomonas vaginalis	tubulin gamma chain, putative	0.0179	0.7609	1
Giardia lamblia	Epsilon tubulin	0.003	0.0737	0.0597
Trypanosoma cruzi	epsilon tubulin, putative	0.007	0.2557	0.3361
Trypanosoma brucei	alpha tubulin, putative	0.0039	0.1161	0.1525
Plasmodium falciparum	tubulin epsilon chain, putative	0.007	0.2557	0.2648
Trypanosoma cruzi	tubulin gamma chain	0.007	0.2557	0.3361
Echinococcus granulosus	Tubulin alpha 1 chain	0.007	0.2557	0.3361
Leishmania major	beta tubulin	0.0179	0.7609	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0041	0.1211	0.1592
Schistosoma mansoni	tubulin subunit alpha	0.007	0.2557	0.3361
Trypanosoma cruzi	alpha tubulin, putative	0.007	0.2557	0.3361
Loa Loa (eye worm)	cytochrome P450 family protein	0.0016	0.0062	0.0062
Loa Loa (eye worm)	tubulin alpha-2 chain	0.007	0.2557	0.2557
Trypanosoma brucei	alpha tubulin	0.007	0.2557	0.3361
Brugia malayi	Tubulin alpha-2 chain	0.007	0.2557	0.2557
Mycobacterium leprae	cell division protein FtsZ	0.003	0.0737	0.5
Schistosoma mansoni	alpha tubulin	0.007	0.2557	0.3361
Trichomonas vaginalis	DNA polymerase eta, putative	0.0041	0.1211	0.069
Brugia malayi	Tubulin alpha chain	0.007	0.2557	0.2557
Entamoeba histolytica	tubulin gamma chain	0.007	0.2557	0.3361
Leishmania major	beta tubulin	0.0179	0.7609	1
Echinococcus multilocularis	peroxisome assembly protein 26	0.007	0.2557	0.3361
Echinococcus granulosus	tubulin alpha chain	0.007	0.2557	0.3361
Loa Loa (eye worm)	tubulin gamma chain	0.007	0.2557	0.2557
Echinococcus granulosus	ATP dependent DNA helicase PIF1	0.0034	0.0889	0.1168

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.58 uM	Inhibitory concentration against Hepatitis C virus NS5B polymerase	ChEMBL.	15863301
IC50 (binding)	= 0.58 uM	Inhibitory concentration against Hepatitis C virus NS5B polymerase	ChEMBL.	15863301

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 6480707

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 337540