Detailed information for compound 337807

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 343.379 | Formula: C21H17N3O2
  • H donors: 2 H acceptors: 3 LogP: 3.22 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1)Nc1ccc(cc1)C(=O)/C=C/c1ccccn1
  • InChi: 1S/C21H17N3O2/c25-20(14-13-17-6-4-5-15-22-17)16-9-11-19(12-10-16)24-21(26)23-18-7-2-1-3-8-18/h1-15H,(H2,23,24,26)/b14-13+
  • InChiKey: JFNGAUFZLKYYQT-BUHFOSPRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0035 0.0315 0.0315
Echinococcus multilocularis muscleblind protein 1 0.0118 0.2613 0.2613
Brugia malayi Hexokinase family protein 0.0125 0.2812 0.2812
Onchocerca volvulus 0.0056 0.0914 0.3225
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0128 0.288 0.5
Echinococcus multilocularis zinc finger transcription factor gli2 0.0244 0.6096 0.6096
Echinococcus multilocularis glycine receptor subunit alpha 1 0.007 0.1278 0.1278
Leishmania major farnesyl pyrophosphate synthase 0.0257 0.6456 0.507
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.007 0.1278 0.1278
Loa Loa (eye worm) polyprenyl synthetase 0.0128 0.288 0.288
Loa Loa (eye worm) hypothetical protein 0.0056 0.0914 0.0914
Loa Loa (eye worm) hypothetical protein 0.0126 0.2835 0.2835
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Echinococcus multilocularis survival motor neuron protein 1 0.017 0.4044 0.4044
Brugia malayi hypothetical protein 0.0028 0.0143 0.0143
Echinococcus granulosus hexokinase 0.0125 0.2812 0.2812
Entamoeba histolytica hexokinase 2 0.0125 0.2812 0.975
Trypanosoma cruzi polyprenyl synthase, putative 0.0386 1 1
Brugia malayi hexokinase 0.0125 0.2812 0.2812
Onchocerca volvulus 0.0056 0.0914 0.3225
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0128 0.288 0.0188
Echinococcus multilocularis nAChR subunit 0.0056 0.0914 0.0914
Onchocerca volvulus 0.007 0.1278 0.4507
Loa Loa (eye worm) hypothetical protein 0.0094 0.1957 0.1957
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.007 0.1278 0.1278
Schistosoma mansoni neurotransmitter gated ion channel 0.0056 0.0914 0.0914
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0036 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.004 0.0457 0.0457
Echinococcus granulosus lamin 0.0041 0.0481 0.0481
Treponema pallidum octaprenyl-diphosphate synthase 0.0386 1 1
Brugia malayi Polyprenyl synthetase family protein 0.0128 0.288 0.288
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0035 0.0315 0.0315
Loa Loa (eye worm) zinc finger protein 0.0244 0.6096 0.6096
Brugia malayi Polyprenyl synthetase family protein 0.0257 0.6456 0.6456
Loa Loa (eye worm) hypothetical protein 0.004 0.0461 0.0461
Echinococcus granulosus glycine receptor subunit beta 0.007 0.1278 0.1278
Echinococcus granulosus lamin dm0 0.0041 0.0481 0.0481
Echinococcus granulosus nAChR subunit 0.007 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.0088 0.1786 0.1786
Loa Loa (eye worm) hypothetical protein 0.0056 0.0914 0.0914
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0036 0.0356 0.0356
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0257 0.6456 0.5
Onchocerca volvulus Hexokinase homolog 0.0079 0.1525 0.538
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0257 0.6456 1
Leishmania major solanesyl-diphosphate synthase, putative 0.0128 0.288 0.0095
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Brugia malayi Cation transporter family protein 0.0126 0.2835 0.2835
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.007 0.1278 0.1278
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.007 0.1278 0.1278
Schistosoma mansoni nAChR subunit 0.007 0.1278 0.1278
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.0257 0.6456 0.507
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0094 0.1957 0.1957
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Echinococcus multilocularis glycine receptor subunit beta 0.007 0.1278 0.1278
Onchocerca volvulus 0.0125 0.2812 0.9917
Loa Loa (eye worm) intermediate filament protein 0.0041 0.0481 0.0481
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.007 0.1278 0.1278
Onchocerca volvulus 0.007 0.1278 0.4507
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.007 0.1278 0.1278
Loa Loa (eye worm) GABA receptor subunit 0.0056 0.0914 0.0914
Loa Loa (eye worm) hypothetical protein 0.017 0.4044 0.4044
Echinococcus granulosus glycine receptor subunit alpha 1 0.007 0.1278 0.1278
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0386 1 1
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Schistosoma mansoni transcription factor LCR-F1 0.0028 0.0143 0.0143
Echinococcus multilocularis lamin 0.0041 0.0481 0.0481
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.0257 0.6456 1
Loa Loa (eye worm) hexokinase 0.0039 0.0428 0.0428
Schistosoma mansoni glutathione synthetase 0.0128 0.288 0.288
Brugia malayi Zinc finger, C2H2 type family protein 0.0244 0.6096 0.6096
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.0257 0.6456 0.6456
Onchocerca volvulus 0.0125 0.2812 0.9917
Loa Loa (eye worm) hypothetical protein 0.0056 0.0914 0.0914
Loa Loa (eye worm) hexokinase 0.0125 0.2812 0.2812
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0056 0.0914 0.0914
Loa Loa (eye worm) LGC-31 protein 0.007 0.1278 0.1278
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.007 0.1278 0.1278
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0036 0.0356 0.0356
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.007 0.1278 0.1278
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0128 0.288 0.5
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0128 0.288 1
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0094 0.1957 0.1957
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0128 0.288 0.0095
Brugia malayi Intermediate filament tail domain containing protein 0.0041 0.0481 0.0481
Schistosoma mansoni hypothetical protein 0.0028 0.0143 0.0143
Echinococcus granulosus glycine receptor subunit alpha 1 0.007 0.1278 0.1278
Onchocerca volvulus Huntingtin homolog 0.0088 0.1786 0.6301
Schistosoma mansoni farnesyl pyrophosphate synthase 0.0257 0.6456 0.6456
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.007 0.1278 0.1278
Onchocerca volvulus 0.007 0.1278 0.4507
Brugia malayi Hexokinase family protein 0.0079 0.1525 0.1525
Echinococcus granulosus muscleblind protein 0.0118 0.2613 0.2613
Echinococcus granulosus hexokinase type 2 0.0125 0.2812 0.2812
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.0088 0.1786 0.1786
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0041 0.0481 0.0481
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0128 0.288 0.288
Echinococcus granulosus glycine receptor subunit beta 0.007 0.1278 0.1278
Leishmania major polyprenyl synthase, putative 0.0386 1 1
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0386 1 1
Onchocerca volvulus 0.0126 0.2835 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0028 0.0143 0.0143
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0386 1 1
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0128 0.288 0.0188
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0128 0.288 0.5
Onchocerca volvulus 0.0125 0.2812 0.9917
Schistosoma mansoni nAChR subunit 0.007 0.1278 0.1278
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.007 0.1278 0.1278
Echinococcus granulosus hexokinase 0.0125 0.2812 0.2812
Loa Loa (eye worm) hypothetical protein 0.0118 0.2613 0.2613
Echinococcus multilocularis muscleblind protein 0.0118 0.2613 0.2613
Echinococcus granulosus hexokinase 0.0125 0.2812 0.2812
Schistosoma mansoni intermediate filament proteins 0.0041 0.0481 0.0481
Trypanosoma cruzi polyprenyl synthase, putative 0.0386 1 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.007 0.1278 0.1278
Echinococcus granulosus glycine receptor subunit alpha 1 0.007 0.1278 0.1278
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0094 0.1957 0.1957
Loa Loa (eye worm) MH2 domain-containing protein 0.0086 0.1725 0.1725
Schistosoma mansoni nAChR subunit 0.007 0.1278 0.1278
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.007 0.1278 0.1278
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.007 0.1278 0.1278
Brugia malayi excitatory GABA receptor EXP-1A 0.007 0.1278 0.1278
Entamoeba histolytica hypothetical protein 0.0056 0.0914 0.2817
Loa Loa (eye worm) polyprenyl synthetase 0.0257 0.6456 0.6456
Loa Loa (eye worm) hypothetical protein 0.0056 0.0914 0.0914
Loa Loa (eye worm) hypothetical protein 0.0056 0.0914 0.0914
Schistosoma mansoni nAChR subunit 0.007 0.1278 0.1278
Echinococcus multilocularis hexokinase 0.0125 0.2812 0.2812
Loa Loa (eye worm) transcription factor SMAD2 0.0086 0.1725 0.1725
Echinococcus multilocularis hexokinase 0.0125 0.2812 0.2812
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0094 0.1957 0.1957
Loa Loa (eye worm) hypothetical protein 0.0113 0.2472 0.2472
Trypanosoma brucei farnesyl pyrophosphate synthase 0.0257 0.6456 1
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.007 0.1278 0.1278
Brugia malayi Muscleblind-like protein 0.0118 0.2613 0.2613
Echinococcus granulosus zinc finger transcription factor gli2 0.0244 0.6096 0.6096
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0094 0.1957 0.1957
Schistosoma mansoni nAChR subunit 0.007 0.1278 0.1278
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0128 0.288 0.288
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.007 0.1278 0.1278
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0128 0.288 1
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0257 0.6456 0.5
Echinococcus granulosus nAChR subunit 0.0056 0.0914 0.0914
Echinococcus multilocularis glycine receptor subunit alpha 1 0.007 0.1278 0.1278
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0036 0.0356 0.0356
Loa Loa (eye worm) ACC-1 protein 0.007 0.1278 0.1278
Onchocerca volvulus 0.0126 0.2835 1
Echinococcus granulosus survival motor neuron protein 1 0.017 0.4044 0.4044
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0028 0.0143 0.0143
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.0257 0.6456 1
Loa Loa (eye worm) hexokinase 0.0125 0.2812 0.2812
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0128 0.288 0.0095
Loa Loa (eye worm) hypothetical protein 0.0056 0.0914 0.0914
Brugia malayi Hexokinase family protein 0.0039 0.0428 0.0428
Schistosoma mansoni lamin 0.0041 0.0481 0.0481
Loa Loa (eye worm) hypothetical protein 0.0085 0.1714 0.1714
Onchocerca volvulus 0.0041 0.0481 0.1697
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0128 0.288 0.288
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0094 0.1957 0.1957
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.007 0.1278 0.1278
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.007 0.1278 0.1278
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0056 0.0914 0.0914
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0094 0.1957 0.1957
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0128 0.288 1
Echinococcus multilocularis glycine receptor subunit beta 0.007 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.0056 0.0914 0.0914
Loa Loa (eye worm) hypothetical protein 0.004 0.0457 0.0457
Loa Loa (eye worm) hexokinase type II 0.0125 0.2812 0.2812
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.007 0.1278 0.1278
Brugia malayi hypothetical protein 0.017 0.4044 0.4044
Loa Loa (eye worm) hypothetical protein 0.0056 0.0914 0.0914
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.007 0.1278 0.1278
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.007 0.1278 0.1278
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.007 0.1278 0.1278
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.007 0.1278 0.1278
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0257 0.6456 1
Onchocerca volvulus 0.0079 0.1525 0.538
Onchocerca volvulus Putative nachr subunit 0.0094 0.1957 0.6903
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0036 0.0356 0.0356
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0036 0.0356 0.0356
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0056 0.0914 0.0914
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Onchocerca volvulus 0.0035 0.0315 0.1111
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0094 0.1957 0.1957
Brugia malayi hypothetical protein 0.0088 0.1786 0.1786
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.007 0.1278 0.1278
Brugia malayi MH2 domain containing protein 0.0086 0.1725 0.1725
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0128 0.288 0.288
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0257 0.6456 1
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.007 0.1278 0.1278
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0386 1 1
Echinococcus multilocularis musashi 0.0041 0.0481 0.0481
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.007 0.1278 0.1278
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0036 0.0356 0.0356
Onchocerca volvulus Huntingtin homolog 0.0088 0.1786 0.6301
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Echinococcus granulosus intermediate filament protein 0.0041 0.0481 0.0481
Loa Loa (eye worm) hypothetical protein 0.0118 0.2613 0.2613
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.007 0.1278 0.1278
Schistosoma mansoni hexokinase 0.0125 0.2812 0.2812
Echinococcus granulosus farnesyl pyrophosphate synthase 0.0257 0.6456 0.6456
Echinococcus multilocularis hexokinase 0.0125 0.2812 0.2812
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0126 0.2835 0.2835
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0128 0.288 0.5
Giardia lamblia Farnesyl diphosphate synthase 0.0257 0.6456 0.5
Schistosoma mansoni nAChR subunit 0.007 0.1278 0.1278
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0036 0.0356 0.0356
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0128 0.288 0.0188
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.007 0.1278 0.1278
Echinococcus multilocularis nAChR subunit 0.007 0.1278 0.1278
Loa Loa (eye worm) ACC-1 protein 0.007 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.007 0.1278 0.1278
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0036 0.0356 0.0356
Brugia malayi Cation transporter family protein 0.007 0.1278 0.1278
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.007 0.1278 0.1278
Brugia malayi hexokinase type II 0.004 0.0457 0.0457
Schistosoma mansoni lamin 0.0041 0.0481 0.0481
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.007 0.1278 0.1278
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0128 0.288 0.0095
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.007 0.1278 0.1278
Echinococcus multilocularis hexokinase type 2 0.0125 0.2812 0.2812
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.0257 0.6456 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0056 0.0914 0.0914
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0056 0.0914 0.0914
Loa Loa (eye worm) hypothetical protein 0.0126 0.2835 0.2835
Onchocerca volvulus 0.0041 0.0481 0.1697
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.007 0.1278 0.1278
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.007 0.1278 0.1278
Schistosoma mansoni survival motor neuron protein 0.0035 0.0315 0.0315
Schistosoma mansoni trans-prenyltransferase 0.0128 0.288 0.288
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Loa Loa (eye worm) hexokinase 0.0079 0.1525 0.1525
Echinococcus multilocularis lamin dm0 0.0041 0.0481 0.0481
Brugia malayi intermediate filament protein 0.0041 0.0481 0.0481
Entamoeba histolytica hexokinase 1 0.0125 0.2812 0.975
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0126 0.2835 0.2835
Loa Loa (eye worm) hypothetical protein 0.0041 0.0481 0.0481
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.0257 0.6456 0.5
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0128 0.288 0.0188
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0056 0.0914 0.0914
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.007 0.1278 0.1278
Onchocerca volvulus 0.0126 0.2835 1
Brugia malayi Cation transporter family protein 0.007 0.1278 0.1278
Schistosoma mansoni nAChR subunit 0.007 0.1278 0.1278
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.0257 0.6456 0.507

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 10 uM Inhibitory concentration of compound against Plasmodium falciparum ChEMBL. 15887974

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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