Detailed information for compound 339437

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 224.279 | Formula: C10H12N2O2S
  • H donors: 2 H acceptors: 2 LogP: 1.1 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: SCCNC(=O)C(=O)Nc1ccccc1
  • InChi: 1S/C10H12N2O2S/c13-9(11-6-7-15)10(14)12-8-4-2-1-3-5-8/h1-5,15H,6-7H2,(H,11,13)(H,12,14)
  • InChiKey: NDECTIXXLKUOQM-UHFFFAOYSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histone deacetylase 9 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei gambiense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium falciparum histone deacetylase 2 Get druggable targets OG5_126654 All targets in OG5_126654
Babesia bovis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium parvum histone deactylase of possible bacterial origin with ankyrin repeats at the N-terminus Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium knowlesi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium knowlesi histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase 7A Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Toxoplasma gondii histone deacetylase HDAC1 Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase hda2 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase 3 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium yoelii Histone deacetylase family, putative Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum IPR000286,Histone deacetylase superfamily;IPR013838,Beta tubulin, autoregulation binding site,domain-containing Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium falciparum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Neospora caninum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0379 0.2947
Loa Loa (eye worm) hypothetical protein 0.0085 0.0592 0.0577
Echinococcus granulosus histone deacetylase 0.0051 0.0146 0.0146
Entamoeba histolytica hypothetical protein 0.0041 0.0021 0.0014
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0135 0.1249 0.1235
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0189 0.0189
Schistosoma mansoni lamin 0.0055 0.0196 0.0194
Echinococcus multilocularis glycogen debranching enzyme 0.0128 0.1147 0.1147
Schistosoma mansoni hypothetical protein 0.0177 0.1789 0.1902
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0021 0.0021
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0379 0.2947
Brugia malayi hypothetical protein 0.0041 0.0021 0.0006
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0108 0.0892 0.7107
Trypanosoma brucei histone deacetylase 3 0.0051 0.0146 0.1058
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0108 0.0892 0.7107
Schistosoma mansoni alpha glucosidase 0.0135 0.1249 0.1322
Leishmania major glycosyl hydrolase-like protein 0.0085 0.0592 0.4674
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0168 0.0168
Onchocerca volvulus Galectin homolog 0.057 0.6929 0.9522
Loa Loa (eye worm) galactoside-binding lectin family protein 0.0121 0.1063 0.1049
Schistosoma mansoni alpha-glucosidase 0.0755 0.9343 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0805 1 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0172 0.1722 0.1722
Echinococcus granulosus histone deacetylase 6 0.0051 0.0146 0.0146
Trichomonas vaginalis alpha-glucosidase, putative 0.0135 0.1249 0.7585
Trichomonas vaginalis sucrase-isomaltase, putative 0.0135 0.1249 0.7585
Echinococcus granulosus intermediate filament protein 0.0055 0.0196 0.0196
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0379 0.0364
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0113 0.0958 0.0958
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0135 0.1249 0.7585
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0189 0.0186
Echinococcus multilocularis histone deacetylase 6 0.0051 0.0146 0.0146
Plasmodium vivax histone deacetylase, putative 0.0051 0.0146 1
Brugia malayi Histone deacetylase family protein 0.0051 0.0146 0.0131
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0379 0.2947
Loa Loa (eye worm) alpha-L-fucosidase 0.0377 0.4409 0.44
Brugia malayi Glycosyl hydrolases family 31 protein 0.0135 0.1249 0.1235
Echinococcus granulosus neutral alpha glucosidase AB 0.0135 0.1249 0.1249
Echinococcus multilocularis histone deacetylase 6 0.0051 0.0146 0.0146
Trichomonas vaginalis alpha-glucosidase, putative 0.0085 0.0592 0.3545
Loa Loa (eye worm) hypothetical protein 0.0097 0.0746 0.0732
Trichomonas vaginalis alpha-glucosidase, putative 0.0085 0.0592 0.3545
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0068 0.0371 0.0356
Echinococcus multilocularis mitogen activated protein kinase 0.0108 0.0892 0.0892
Echinococcus granulosus mitogen activated protein kinase 0.0108 0.0892 0.0892
Echinococcus multilocularis irregular chiasm roughest protein immunoglobulin set domain containing protein 0.0053 0.0176 0.0176
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0015 0.5
Echinococcus granulosus mitogen activated protein kinase 3 0.0108 0.0892 0.0892
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0168 0.0168
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0168 0.0168
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0172 0.1722 0.1722
Plasmodium falciparum histone deacetylase 2 0.0051 0.0146 1
Brugia malayi Alpha-L-fucosidase family protein 0.0377 0.4409 0.44
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0805 1 1
Entamoeba histolytica glycogen debranching enzyme, putative 0.0128 0.1147 0.2852
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0015 0.0015
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0108 0.0892 0.7107
Trichomonas vaginalis CMGC family protein kinase 0.0108 0.0892 0.539
Brugia malayi hypothetical protein 0.0068 0.0371 0.0356
Loa Loa (eye worm) hypothetical protein 0.0055 0.0196 0.0181
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0379 0.039
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0128 0.1147 0.6958
Schistosoma mansoni histone deacetylase 4 5 0.0051 0.0146 0.014
Brugia malayi galectin 0.0121 0.1063 0.1049
Brugia malayi Galactoside-binding lectin family protein 0.0121 0.1063 0.1049
Schistosoma mansoni hypothetical protein 0.0063 0.0298 0.0302
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0085 0.0592 0.056
Echinococcus multilocularis Galectin, carbohydrate recognition domain 0.0121 0.1063 0.1063
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0135 0.1249 1
Echinococcus multilocularis histone deacetylase 6 0.0051 0.0146 0.0146
Echinococcus granulosus lysosomal alpha glucosidase 0.0805 1 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0068 0.0371 0.0356
Toxoplasma gondii Amylo-alpha-1,6-glucosidase 0.0128 0.1147 0.9174
Echinococcus granulosus beta galactosidase 0.0097 0.0746 0.0746
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0165 0.1642 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0113 0.0958 0.0958
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0015 0.5
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0379 0.0379
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0135 0.1249 0.7585
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0168 0.0168
Loa Loa (eye worm) amylo-alpha-1,6-glucosidase 0.0062 0.0291 0.0276
Schistosoma mansoni hypothetical protein 0.0102 0.0813 0.0855
Loa Loa (eye worm) hypothetical protein 0.057 0.6929 0.6924
Echinococcus multilocularis mitogen activated protein kinase 3 0.0108 0.0892 0.0892
Schistosoma mansoni lipoxygenase 0.0101 0.0803 0.0844
Schistosoma mansoni hypothetical protein 0.0164 0.1623 0.1724
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.023 0.0215
Plasmodium vivax histone deacetylase 2, putative 0.0051 0.0146 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0379 0.2947
Loa Loa (eye worm) hypothetical protein 0.0057 0.023 0.0215
Schistosoma mansoni intermediate filament proteins 0.0055 0.0196 0.0194
Loa Loa (eye worm) hypothetical protein 0.0051 0.0146 0.0131
Trypanosoma brucei glucosidase, putative 0.0135 0.1249 1
Echinococcus multilocularis conserved hypothetical protein 0.0053 0.0176 0.0176
Echinococcus multilocularis geminin 0.0177 0.1789 0.1789
Loa Loa (eye worm) histone deacetylase 7A 0.0051 0.0146 0.0131
Giardia lamblia 4-alpha-glucanotransferase, amylo-alpha-1,6-glucosidase 0.0128 0.1147 0.2852
Loa Loa (eye worm) histone deacetylase 0.0051 0.0146 0.0131
Echinococcus multilocularis beta galactosidase 0.0097 0.0746 0.0746
Echinococcus granulosus histone deacetylase 6 0.0051 0.0146 0.0146
Echinococcus granulosus nephrin 0.0053 0.0176 0.0176
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0015 0.5
Trypanosoma cruzi histone deacetylase, putative 0.0051 0.0146 0.1058
Entamoeba histolytica hypothetical protein 0.0098 0.0761 0.1878
Echinococcus multilocularis musashi 0.0055 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0121 0.1063 0.1049
Schistosoma mansoni beta-galactosidase 0.0097 0.0746 0.0784
Leishmania major histone deacetylase, putative 0.0051 0.0146 0.1058
Trichomonas vaginalis maltase-glucoamylase, putative 0.0085 0.0592 0.3545
Trichomonas vaginalis alpha-glucosidase, putative 0.0135 0.1249 0.7585
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0135 0.1249 0.3109
Schistosoma mansoni lamin 0.0055 0.0196 0.0194
Loa Loa (eye worm) hypothetical protein 0.0121 0.1063 0.1049
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0085 0.0592 0.3545
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0108 0.0892 0.7107
Trichomonas vaginalis alpha-glucosidase, putative 0.0135 0.1249 0.7585
Brugia malayi intermediate filament protein 0.0055 0.0196 0.0181
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0168 0.0164
Trypanosoma brucei protein kinase, putative 0.0108 0.0892 0.7107
Echinococcus granulosus geminin 0.0177 0.1789 0.1789
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0379 0.0379
Giardia lamblia Kinase, CMGC MAPK 0.0108 0.0892 0.2209
Brugia malayi Galactoside-binding lectin family protein 0.0121 0.1063 0.1049
Echinococcus granulosus fucosidase alpha L 1 tissue 0.0377 0.4409 0.4409
Echinococcus multilocularis lamin dm0 0.0055 0.0196 0.0196
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0168 0.0153
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0108 0.0892 0.7107
Brugia malayi galectin 0.0419 0.4959 0.4951
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0165 0.1642 1
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0892 0.094
Echinococcus multilocularis histone deacetylase 7 0.0051 0.0146 0.0146
Trypanosoma brucei histone deacetylase 4 0.0051 0.0146 0.1058
Brugia malayi Galactoside-binding lectin family protein 0.0121 0.1063 0.1049
Trichomonas vaginalis alpha-glucosidase, putative 0.0085 0.0592 0.3545
Brugia malayi Immunoglobulin I-set domain containing protein 0.0068 0.0371 0.0356
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0113 0.0958 0.0944
Schistosoma mansoni hypothetical protein 0.0041 0.0021 0.0006
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.023 0.0215
Trichomonas vaginalis CMGC family protein kinase 0.0108 0.0892 0.539
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0345 0.3983 1
Brugia malayi Amylo-alpha-1,6-glucosidase family protein 0.0128 0.1147 0.1133
Schistosoma mansoni hypothetical protein 0.0053 0.0176 0.0172
Schistosoma mansoni histone deacetylase hda2 0.0051 0.0146 0.014
Trypanosoma cruzi histone deacetylase, putative 0.0051 0.0146 0.1058
Trypanosoma brucei glycosyl hydrolase-like protein 0.0085 0.0592 0.4674
Mycobacterium ulcerans alpha-L-fucosidase 0.0377 0.4409 1
Schistosoma mansoni hypothetical protein 0.0177 0.1789 0.1902
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0085 0.0592 0.3545
Trichomonas vaginalis alpha-glucosidase, putative 0.0135 0.1249 0.7585
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0168 0.0164
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0196 0.0181
Echinococcus multilocularis nephrin 0.0053 0.0176 0.0176
Echinococcus granulosus histone deacetylase 6 0.0051 0.0146 0.0146
Echinococcus multilocularis lysosomal alpha glucosidase 0.0805 1 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0379 0.0916
Loa Loa (eye worm) galectin 0.0419 0.4959 0.4951
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0108 0.0892 0.7107
Brugia malayi Immunoglobulin I-set domain containing protein 0.0068 0.0371 0.0356
Schistosoma mansoni alpha-l-fucosidase 0.0377 0.4409 0.471
Echinococcus multilocularis histone deacetylase 0.0051 0.0146 0.0146
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.023 0.0215
Schistosoma mansoni hypothetical protein 0.0053 0.0176 0.0172
Trichomonas vaginalis alpha-glucosidase, putative 0.0085 0.0592 0.3545
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0135 0.1249 0.3109
Echinococcus multilocularis fucosidase, alpha L 1, tissue 0.0377 0.4409 0.4409
Trichomonas vaginalis alpha-glucosidase, putative 0.0135 0.1249 0.7585
Echinococcus granulosus histone deacetylase 7 0.0051 0.0146 0.0146
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0085 0.0592 0.1453
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0098 0.0761 0.1878
Echinococcus granulosus Immunoglobulin 0.0053 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0054 0.0183 0.0168
Echinococcus granulosus nephrin 0.0053 0.0176 0.0176
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0015 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0135 0.1249 1
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0335 0.1965
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0128 0.1147 0.6958
Entamoeba histolytica hypothetical protein 0.0041 0.0021 0.0014
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0021 0.0021
Trichomonas vaginalis maltase-glucoamylase, putative 0.0135 0.1249 0.7585
Loa Loa (eye worm) galactoside-binding lectin family protein 0.0121 0.1063 0.1049
Trichomonas vaginalis CMGC family protein kinase 0.0108 0.0892 0.539
Trypanosoma cruzi hypothetical protein, conserved 0.0135 0.1249 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0135 0.1249 0.1249
Trypanosoma brucei histone deacetylase, putative 0.0051 0.0146 0.1058
Echinococcus multilocularis lamin 0.0055 0.0196 0.0196
Trypanosoma cruzi histone deacetylase, putative 0.0051 0.0146 0.1058
Leishmania major histone deacetylase, putative 0.0051 0.0146 0.1058
Brugia malayi Galactoside-binding lectin family protein 0.057 0.6929 0.6924
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0168 0.0164
Trichomonas vaginalis CMGC family protein kinase 0.0108 0.0892 0.539
Schistosoma mansoni histone deacetylase 4 5 0.0051 0.0146 0.014
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0379 0.0364
Loa Loa (eye worm) hypothetical protein 0.0293 0.3303 0.3293
Schistosoma mansoni hypothetical protein 0.0092 0.0684 0.0716
Loa Loa (eye worm) hypothetical protein 0.0128 0.1147 0.1133
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0168 0.0153
Toxoplasma gondii histone deacetylase HDAC1 0.0051 0.0146 0.1058
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0108 0.0892 0.7107
Loa Loa (eye worm) hypothetical protein 0.0113 0.0958 0.0944
Echinococcus granulosus Galectin carbohydrate recognition domain 0.0121 0.1063 0.1063
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0108 0.0892 0.0878
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0196 0.0181
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0085 0.0592 0.4674
Echinococcus multilocularis Immunoglobulin 0.0053 0.0176 0.0176
Entamoeba histolytica hypothetical protein 0.0041 0.0021 0.0014
Echinococcus granulosus lamin dm0 0.0055 0.0196 0.0196
Schistosoma mansoni lipoxygenase 0.0172 0.1722 0.183
Echinococcus granulosus glycogen debranching enzyme 0.0128 0.1147 0.1147
Schistosoma mansoni galectin 0.0121 0.1063 0.1123
Plasmodium falciparum histone deacetylase, putative 0.0051 0.0146 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0085 0.0592 0.4674
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0196 0.0181
Loa Loa (eye worm) galactoside-binding lectin family protein 0.0121 0.1063 0.1049
Onchocerca volvulus Galectin homolog 0.0121 0.1063 0.1226
Trichomonas vaginalis alpha-glucosidase, putative 0.0085 0.0592 0.3545
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0108 0.0892 0.7107
Loa Loa (eye worm) MBCTL1 0.0054 0.0189 0.0174
Brugia malayi Histone deacetylase family protein 0.0051 0.0146 0.0131
Echinococcus granulosus irregular chiasm roughest protein 0.0053 0.0176 0.0176
Loa Loa (eye worm) galectin 0.0121 0.1063 0.1049
Onchocerca volvulus 0.0596 0.7267 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0051 0.0146 0.0131
Entamoeba histolytica hypothetical protein 0.0041 0.0021 0.0014
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0021 0.0006
Brugia malayi Glycosyl hydrolases family 31 protein 0.0085 0.0592 0.0577
Brugia malayi MAP kinase sur-1 0.0108 0.0892 0.0878
Echinococcus granulosus lamin 0.0055 0.0196 0.0196
Schistosoma mansoni alpha-glucosidase 0.0755 0.9343 1
Giardia lamblia DNA repair protein RAD52 0.0345 0.3983 1
Leishmania major alpha glucosidase II subunit, putative 0.0135 0.1249 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.8 uM In vitro inhibitory concentration against Histone deacetylase; Control value 0.06 uM ChEMBL. 15808449
IC50 (binding) = 2.8 uM In vitro inhibitory concentration against Histone deacetylase; Control value 0.06 uM ChEMBL. 15808449

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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