Detailed information for compound 342520

Basic information

Technical information
  • TDR Targets ID: 342520
  • Name: (4-iodonaphthalen-1-yl)-[1-[(1-methylpiperidi n-2-yl)methyl]indol-3-yl]methanone
  • MW: 508.394 | Formula: C26H25IN2O
  • H donors: 0 H acceptors: 1 LogP: 6.13 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 2
  • SMILES: CN1CCCCC1Cn1cc(c2c1cccc2)C(=O)c1ccc(c2c1cccc2)I
  • InChi: 1S/C26H25IN2O/c1-28-15-7-6-8-18(28)16-29-17-23(21-11-4-5-12-25(21)29)26(30)22-13-14-24(27)20-10-3-2-9-19(20)22/h2-5,9-14,17-18H,6-8,15-16H2,1H3
  • InChiKey: YQBRYEMSCWENAH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4-iodo-1-naphthyl)-[1-[(1-methyl-2-piperidyl)methyl]indol-3-yl]methanone
  • (4-iodo-1-naphthyl)-[1-[(1-methyl-2-piperidinyl)methyl]-3-indolyl]methanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Cannabinoid CB1 receptor Starlite/ChEMBL References
Mus musculus cannabinoid receptor 2 (macrophage) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major importin beta-1 subunit, putative 0.0027 0.003 0.0109
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0008 0.0007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0023 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0008 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0023 0.0084
Echinococcus multilocularis snurportin 1 0.0349 0.0502 0.7493
Brugia malayi CXXC zinc finger family protein 0.0071 0.0094 0.013
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0023 0.0084
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0025
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0017 0.0259
Loa Loa (eye worm) hypothetical protein 0.017 0.0239 0.4762
Echinococcus multilocularis muscleblind protein 0.017 0.0239 0.3568
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0008 0.0118
Plasmodium falciparum telomerase reverse transcriptase 0.1869 0.2725 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0158
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0051 0.0759
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0112 0.0155 0.2731
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0008 0.0158
Schistosoma mansoni importin beta-1 0.0033 0.0039 0.0582
Schistosoma mansoni cpg binding protein 0.0071 0.0094 0.1409
Echinococcus granulosus Chromo domain 0.0013 0.001 0.0156
Echinococcus multilocularis dna polymerase eta 0.0022 0.0023 0.0346
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.0001 0.0003
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0017 0.0063
Trichomonas vaginalis flap endonuclease-1, putative 0.003 0.0034 0.0768
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0022 0.5
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0008 0.0011
Toxoplasma gondii hypothetical protein 0.0096 0.0132 0.0483
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0023 0.0032
Echinococcus granulosus dnaJ subfamily B 0.0464 0.067 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0039 0.0777
Brugia malayi hypothetical protein 0.0041 0.0051 0.007
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0017 0.0346
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0343 0.0493 0.1805
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0008 0.0118
Echinococcus multilocularis BRK domain containing protein 0.0013 0.001 0.0156
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.0062 0.0226
Echinococcus granulosus BRK domain containing protein 0.0013 0.001 0.0156
Brugia malayi MH1 domain containing protein 0.0009 0.0005 0.0006
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.003 0.0034 0.0125
Schistosoma mansoni polybromo-1 0.0007 0.0001 0.0022
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0022 0.0081
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0008 0.0118
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0008 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Plasmodium falciparum flap endonuclease 1 0.003 0.0034 0.0125
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0008 0.0118
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0023 0.0081
Brugia malayi SNF2 family N-terminal domain containing protein 0.0007 0.0001 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0008 0.0118
Echinococcus multilocularis disco interacting protein 2 0.0044 0.0055 0.0822
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0017 0.0063
Plasmodium falciparum DEAD/DEAH box helicase, putative 0.0012 0.0008 0.003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0008 0.0011
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0023 0.0244
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0084 0.0309
Brugia malayi nuclear receptor NHR-88 0.0011 0.0008 0.0011
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0017 0.0259
Schistosoma mansoni hypothetical protein 0.0349 0.0502 0.7493
Schistosoma mansoni ap endonuclease 0.0021 0.0022 0.0334
Echinococcus multilocularis BRK domain containing protein 0.0013 0.001 0.0156
Plasmodium vivax hypothetical protein, conserved 0.0007 0.0001 0.0002
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0051 0.0759
Brugia malayi Disco-interacting protein 2 homolog 0.0044 0.0055 0.0076
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0008 0.0118
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0096 0.0132 0.0483
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0022 0.0024 0.0087
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0007 0.0001 0.0003
Schistosoma mansoni hypothetical protein 0.0192 0.0273 0.4065
Giardia lamblia DINP protein human, muc B family 0.0022 0.0023 0.0081
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0013 0.0048
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0003 0.0044
Schistosoma mansoni smad1 5 8 and 0.0009 0.0005 0.0069
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0039 0.0143
Echinococcus granulosus global transcription activator snf2l2 0.0076 0.0103 0.1531
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0005 0.0069
Toxoplasma gondii RNA-directed DNA polymerase 0.1869 0.2725 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0008 0.0007
Leishmania major DNA polymerase kappa, putative 0.0007 0.0001 0.0003
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0005 0.0069
Onchocerca volvulus 0.0044 0.0055 0.0054
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.003 0.0034 0.0125
Echinococcus multilocularis polybromo 1 0.0007 0.0001 0.0022
Echinococcus multilocularis BRK domain containing protein 0.0013 0.001 0.0156
Echinococcus granulosus smad 0.0009 0.0005 0.0069
Entamoeba histolytica hypothetical protein 0.0027 0.003 0.0524
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0008 0.0118
Loa Loa (eye worm) CXXC zinc finger family protein 0.0071 0.0094 0.1881
Plasmodium vivax helicase, putative 0.0007 0.0001 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0008 0.0011
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0023 0.0405
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0343 0.0493 0.1808
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0023 0.0084
Schistosoma mansoni cpg binding protein 0.0072 0.0097 0.145
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0022 0.0024 0.0087
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0022 0.0498
Plasmodium vivax telomerase reverse transcriptase, putative 0.1869 0.2725 1
Echinococcus multilocularis BRK domain containing protein 0.0013 0.001 0.0156
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0008 0.0011
Echinococcus multilocularis importin 5 0.0006 0 0.0003
Brugia malayi Flap endonuclease-1 0.003 0.0034 0.0047
Leishmania major telomerase reverse transcriptase, putative 0.1869 0.2725 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0023 0.0084
Loa Loa (eye worm) hypothetical protein 0.0022 0.0023 0.0461
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0008 0.0118
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0008 0.0118
Schistosoma mansoni smad1 5 8 and 0.0009 0.0005 0.0069
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0003 0.0044
Echinococcus multilocularis cpg binding protein 0.0072 0.0097 0.145
Plasmodium vivax DEAD/DEAH helicase, putative 0.0012 0.0008 0.003
Echinococcus multilocularis Chromo domain 0.0013 0.001 0.0156
Schistosoma mansoni hypothetical protein 0.0464 0.067 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0022 0.0081
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0022 0.021
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0008 0.0118
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0005 0.0092
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0023 0.0346
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0022
Echinococcus multilocularis BRK domain containing protein 0.0013 0.001 0.0156
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0013 0.001 0.0156
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0008 0.0158
Echinococcus granulosus polybromo 1 0.0007 0.0001 0.0022
Echinococcus granulosus importin subunit beta 1 0.0033 0.0039 0.0582
Echinococcus granulosus Smad4 0.0009 0.0005 0.0069
Toxoplasma gondii DNA methyltransferase 2, putative 0.0022 0.0024 0.0087
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0022 0.0024 0.0357
Schistosoma mansoni helicase 0.0076 0.0103 0.1531
Mycobacterium ulcerans hypothetical protein 0.0181 0.0255 0.5726
Giardia lamblia DNA repair protein RAD52 0.0395 0.0568 0.2083
Toxoplasma gondii hypothetical protein 0.0055 0.0072 0.0264
Giardia lamblia Flap structure-specific endonuclease 0.003 0.0034 0.0122
Schistosoma mansoni helicase 0.0007 0.0001 0.0013
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0017 0.0259
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0008 0.0158
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0001 0.0003
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.003 0.0669
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0162 0.0229 0.0838
Schistosoma mansoni hypothetical protein 0.0015 0.0013 0.0196
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0022 0.0031
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0008 0.0118
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0023 0.0084
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0023 0.0081
Trichomonas vaginalis helicase, putative 0.0007 0.0002 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0008 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0013 0.0048
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0008 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0008 0.0158
Schistosoma mansoni hypothetical protein 0.0192 0.0273 0.4065
Schistosoma mansoni ap endonuclease 0.0021 0.0022 0.0334
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Loa Loa (eye worm) BRM protein 0.0049 0.0062 0.1241
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0008 0.0011
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0008 0.0011
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.0001 0.0003
Loa Loa (eye worm) flap endonuclease-1 0.003 0.0034 0.0684
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0008 0.0118
Echinococcus granulosus disco interacting protein 2 0.0044 0.0055 0.0822
Schistosoma mansoni hypothetical protein 0.0013 0.001 0.0156
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0008 0.0118
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0022 0.0024 0.0087
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0023 0.0346
Brugia malayi polybromodomain protein 0.0007 0.0001 0.0002
Plasmodium falciparum DNA repair protein REV1, putative 0.0007 0.0001 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0013 0.0048
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0092 0.1377
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0158
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0017 0.0063
Plasmodium vivax flap endonuclease 1, putative 0.003 0.0034 0.0125
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0044 0.0055 0.0822
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0039 0.0143
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0062 0.0222
Loa Loa (eye worm) transcription factor SMAD2 0.0136 0.0189 0.377
Echinococcus granulosus muscleblind protein 0.017 0.0239 0.3568
Brugia malayi BRM protein 0.0076 0.0103 0.0141
Echinococcus multilocularis muscleblind protein 1 0.017 0.0239 0.3568
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0008 0.0011
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0022 0.5
Plasmodium vivax importin-beta 2, putative 0.0033 0.0039 0.0143
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0017 0.0259
Trypanosoma brucei unspecified product 0.0022 0.0023 0.0084
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0023 0.0244
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0023 0.0084
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0022 0.0445
Leishmania major mitochondrial DNA polymerase beta 0.0343 0.0493 0.1808
Entamoeba histolytica hypothetical protein 0.0041 0.0051 0.0892
Schistosoma mansoni cpg binding protein 0.0072 0.0097 0.145
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Loa Loa (eye worm) helicase DNA-binding protein 0.0013 0.001 0.0208
Mycobacterium ulcerans glutaminase 0.031 0.0445 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0006 0.0088
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0017 0.0063
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0003 0.0044
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0008 0.0118
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0023 0.0461
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0022 0.0334
Trichomonas vaginalis lymphoid specific helicase, putative 0.0014 0.0011 0.0253
Loa Loa (eye worm) hypothetical protein 0.0044 0.0055 0.1097
Brugia malayi Telomerase reverse transcriptase 0.4973 0.7266 1
Schistosoma mansoni hypothetical protein 0.0041 0.0051 0.0759
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0008 0.0007
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1869 0.2725 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0005 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Brugia malayi SET domain containing protein 0.0008 0.0002 0.0003
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0023 0.0084
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0008 0.0158
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0023 0.0084
Leishmania major DNA polymerase eta, putative 0.0022 0.0023 0.0084
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0008 0.0118
Echinococcus granulosus transportin 1 0.0006 0 0.0003
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0008 0.0118
Brugia malayi steroid hormone receptor 0.0011 0.0008 0.0011
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0023 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0023 0.0084
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Schistosoma mansoni DNA polymerase IV / kappa 0.0007 0.0001 0.0016
Loa Loa (eye worm) BRM protein 0.0039 0.0049 0.0972
Echinococcus multilocularis dnaJ subfamily B 0.0464 0.067 1
Echinococcus multilocularis translational activator gcn1 0.0006 0 0.0003
Leishmania major DNA polymerase kappa, putative 0.0022 0.0023 0.0084
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0158
Trichomonas vaginalis glutaminase, putative 0.031 0.0445 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0008 0.0011
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0162 0.0229 0.0838
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.003 0.0669
Brugia malayi RNA, U transporter 1 0.0093 0.0127 0.0175
Schistosoma mansoni glutaminase 0.031 0.0445 0.6639
Echinococcus multilocularis Smad4 0.0009 0.0005 0.0069
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.0001 0.0003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Echinococcus multilocularis Helicase SANT associated, DNA binding 0.0007 0.0001 0.0013
Brugia malayi nuclear hormone receptor 0.0011 0.0008 0.0011
Echinococcus granulosus importin 5 0.0006 0 0.0003
Brugia malayi polk-prov protein 0.0007 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0158
Echinococcus granulosus dna polymerase kappa 0.0022 0.0023 0.0346
Trypanosoma brucei unspecified product 0.0015 0.0013 0.0048
Schistosoma mansoni hypothetical protein 0.0007 0.0001 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0022 0.0024 0.0418
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0023 0.0084
Loa Loa (eye worm) SNF2 family domain-containing protein 0.0007 0.0001 0.0017
Plasmodium falciparum Snf2-related CBP activator, putative 0.0007 0.0001 0.0002
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0051 0.0759
Leishmania major DNA polymerase eta, putative 0.0007 0.0001 0.0003
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0003 0.0044
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0017 0.0063
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0059 0.0077 0.0279
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0023 0.0084
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0023 0.0498
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0008 0.0118
Echinococcus multilocularis smad 0.0009 0.0005 0.0069
Schistosoma mansoni flap endonuclease-1 0.0027 0.003 0.0451
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0023 0.0081
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0001 0.0003
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0022 0.0498
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0158
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0017 0.0259
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0022 0.0078
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0002 0.0039
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0022 0.0078
Brugia malayi Smad1 0.0009 0.0005 0.0006
Echinococcus granulosus dna polymerase eta 0.0022 0.0023 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0395 0.0568 1
Entamoeba histolytica hypothetical protein 0.0041 0.0051 0.0892
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.003 0.0106
Echinococcus multilocularis BRK domain 0.0013 0.001 0.0156
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0023 0.0084
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0017 0.0024
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0062 0.0222
Leishmania major flap endonuclease-1 (FEN-1), putative 0.003 0.0034 0.0125
Echinococcus multilocularis flap endonuclease 1 0.003 0.0034 0.0513
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0008 0.0118
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0007 0.0001 0.0003
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0005 0.0092
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0023 0.0084
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0162 0.0229 0.0835
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0008 0.0011
Onchocerca volvulus 0.0011 0.0008 0.0007
Loa Loa (eye worm) importin-beta domain-containing protein 0.0006 0 0.0004
Entamoeba histolytica hypothetical protein 0.0112 0.0155 0.2731
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0008 0.0011
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0008 0.0118
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0017 0.0259
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0008 0.0158
Brugia malayi isocitrate dehydrogenase 0.0018 0.0017 0.0024
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0008 0.0118
Schistosoma mansoni coup transcription factor 0.0011 0.0008 0.0118
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0017 0.0259
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0008 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0005 0.0069
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0158
Mycobacterium tuberculosis Conserved hypothetical protein 0.0181 0.0255 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Giardia lamblia Telomerase catalytic subunit 0.1869 0.2725 1
Leishmania major DNA damage repair protein, putative 0.0007 0.0001 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0005 0.0069
Echinococcus granulosus DNA methyltransferase 2, putative 0.0022 0.0024 0.0357
Loa Loa (eye worm) kap beta 3 protein 0.0006 0 0.0004
Schistosoma mansoni Smad4 0.0009 0.0005 0.0069
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0003 0.0044
Entamoeba histolytica Flap nuclease, putative 0.003 0.0034 0.0602
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0006 0.0008
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0023 0.0517
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0014 0.0011 0.0041
Echinococcus multilocularis global transcription activator snf2l2 0.0076 0.0103 0.1531
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0022 0.039
Echinococcus granulosus snurportin 1 0.0349 0.0502 0.7493
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.0001 0.0003
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0007 0.0001 0.0003
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0008 0.0118
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0023 0.0081
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0002 0.0039
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0017 0.0063
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0022 0.0078
Schistosoma mansoni smad 0.0009 0.0005 0.0069
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0039 0.0143
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0008 0.0158
Echinococcus multilocularis geminin 0.0192 0.0273 0.4065
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.0062 0.0222
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.001 0.0014
Toxoplasma gondii exonuclease III APE 0.0021 0.0022 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0008 0.0011
Echinococcus granulosus cpg binding protein 0.0072 0.0097 0.145
Schistosoma mansoni importin-beta 2 0.0006 0 0.0003
Echinococcus multilocularis helicase 0.0007 0.0001 0.0013
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0017 0.006
Brugia malayi ecdysteroid receptor 0.0011 0.0008 0.0011
Echinococcus granulosus Helicase SANT associated DNA binding 0.0007 0.0001 0.0013
Schistosoma mansoni DNA polymerase eta 0.0022 0.0023 0.0346
Loa Loa (eye worm) glutaminase 0.031 0.0445 0.8861
Echinococcus granulosus geminin 0.0192 0.0273 0.4065
Loa Loa (eye worm) Smad1 0.0009 0.0005 0.0092
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0008 0.0118
Echinococcus multilocularis transportin 1 0.0006 0 0.0003
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0008 0.0118
Echinococcus granulosus helicase 0.0007 0.0001 0.0013
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0012 0.0008 0.003
Echinococcus granulosus translational activator gcn1 0.0006 0 0.0003
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0017 0.006
Leishmania major modification methylase-like protein 0.0022 0.0024 0.0087
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0023 0.0498
Trypanosoma brucei chrX additional, unordered contigs 0.0007 0.0001 0.0003
Brugia malayi Importin beta-1 subunit 0.0033 0.0039 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0008 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Plasmodium vivax DNA repair protein REV1, putative 0.0007 0.0001 0.0003
Schistosoma mansoni smad1 5 8 and 0.0009 0.0005 0.0069
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0158
Plasmodium falciparum importin beta, putative 0.0033 0.0039 0.0143
Loa Loa (eye worm) MH2 domain-containing protein 0.0136 0.0189 0.377
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0022 0.0081
Onchocerca volvulus 0.0071 0.0094 0.0094
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0022 0.0081
Entamoeba histolytica hypothetical protein 0.0041 0.0051 0.0892
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0023 0.0084
Brugia malayi MH2 domain containing protein 0.0009 0.0005 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0023 0.0084
Loa Loa (eye worm) histone methyltransferase 0.001 0.0006 0.0117
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.003 0.0034 0.0122
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0008 0.0118
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0008 0.0118
Entamoeba histolytica hypothetical protein 0.0041 0.0051 0.0892
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0023 0.0346
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0022 0.0024 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Brugia malayi Muscleblind-like protein 0.017 0.0239 0.0329
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0008 0.0158
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0023 0.0346
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0006 0.0088
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0349 0.0502 1
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0022 0.0024 0.0357
Schistosoma mansoni helicase 0.0007 0.0001 0.0013
Trypanosoma brucei unspecified product 0.0015 0.0013 0.0048
Echinococcus multilocularis BRK domain containing protein 0.0013 0.001 0.0156
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0023 0.0346
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0008 0.0118
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0022 0.0479
Brugia malayi glutaminase DH11.1 0.031 0.0445 0.0613
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0017 0.0063
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0008 0.0011
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0023 0.0517
Trypanosoma brucei telomerase reverse transcriptase 0.1869 0.2725 1
Brugia malayi MH1 domain containing protein 0.0009 0.0005 0.0006
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1869 0.2725 1
Brugia malayi MH2 domain containing protein 0.0136 0.0189 0.0261
Loa Loa (eye worm) glutaminase 2 0.031 0.0445 0.8861
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0039 0.0582
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0008 0.0118
Loa Loa (eye worm) hypothetical protein 0.017 0.0239 0.4762
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0022 0.0334
Trichomonas vaginalis importin beta-1, putative 0.0027 0.003 0.0669
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0008 0.0118
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0343 0.0493 0.1805
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0029
Echinococcus granulosus flap endonuclease 1 0.003 0.0034 0.0513
Brugia malayi MH2 domain containing protein 0.0009 0.0005 0.0006

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 5.3 nM Binding affinity towards mouse spleen cannabinoid receptor 2 using [3H]CP-55,940 ChEMBL. 16190764
Ki (binding) = 5.3 nM Binding affinity towards mouse spleen cannabinoid receptor 2 using [3H]CP-55,940 ChEMBL. 16190764
Ki (binding) = 10 nM Binding affinity towards rat forebrain cannabinoid receptor 1 using [3H]CP-55,940 ChEMBL. 16190764
Ki (binding) = 10 nM Binding affinity towards rat forebrain cannabinoid receptor 1 using [3H]CP-55,940 ChEMBL. 16190764

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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