Detailed information for compound 342933

Basic information

Technical information
  • TDR Targets ID: 342933
  • Name: 2-amino-4-(3-bromo-4,5-dimethoxyphenyl)-7,8-d ihydroxy-4H-chromene-3-carbonitrile
  • MW: 419.226 | Formula: C18H15BrN2O5
  • H donors: 3 H acceptors: 3 LogP: 3.22 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C(N)Oc2c(C1c1cc(Br)c(c(c1)OC)OC)ccc(c2O)O
  • InChi: 1S/C18H15BrN2O5/c1-24-13-6-8(5-11(19)17(13)25-2)14-9-3-4-12(22)15(23)16(9)26-18(21)10(14)7-20/h3-6,14,22-23H,21H2,1-2H3
  • InChiKey: NXJDWSFSAVXKMI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-amino-4-(3-bromo-4,5-dimethoxy-phenyl)-7,8-dihydroxy-4H-chromene-3-carbonitrile
  • 2-amino-4-(3-bromo-4,5-dimethoxyphenyl)-7,8-dihydroxy-4H-1-benzopyran-3-carbonitrile
  • 2-azanyl-4-(3-bromo-4,5-dimethoxy-phenyl)-7,8-dihydroxy-4H-chromene-3-carbonitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0171 0.0417
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0078 0.0081
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0222 0.0541
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0306 0.0306
Echinococcus multilocularis caspase 2 0.0026 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.005 0.0483 0.0498
Echinococcus granulosus jun protein 0.0084 0.0903 0.0903
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0025 0.0175 0.0175
Trypanosoma brucei unspecified product 0.0073 0.0771 0.1872
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0091 0.0999 0.1412
Mycobacterium ulcerans putative regulatory protein 0.0066 0.0681 0.0644
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0241 0.0341
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0025 0.0175 0.0248
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.0175 0.0427
Schistosoma mansoni caspase-7 (C14 family) 0.0026 0.0188 0.0281
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0052 0.0507 0.1198
Trypanosoma cruzi small ubiquitin protein, putative 0.0031 0.0241 0.0581
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.0175 0.0248
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0078 0.0081
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.0175 0.0248
Trypanosoma cruzi DNA polymerase eta, putative 0.0157 0.1818 0.4424
Echinococcus granulosus dna polymerase kappa 0.0159 0.1846 0.1846
Schistosoma mansoni phosphoglycerate kinase 0.0339 0.4106 0.6145
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0188 0.0458
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.1039 0.1039
Entamoeba histolytica hypothetical protein 0.0012 0.0003 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0427 0.0639
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0025 0.0175 0.0175
Giardia lamblia Kinase, PLK 0.0094 0.1039 0.2197
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.1052 0.1052
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0066 0.0681 0.0644
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0078 0.0117
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0339 0.4106 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0118 0.133 0.133
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0188 0.0266
Trypanosoma cruzi metacaspase, putative 0.0026 0.0188 0.0451
Schistosoma mansoni hypothetical protein 0.0036 0.0306 0.0457
Brugia malayi hypothetical protein 0.0036 0.0306 0.0306
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0066 0.0681 0.1614
Brugia malayi jmjC domain containing protein 0.0035 0.0299 0.0299
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0025 0.0175 0.0385
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0125 0.1417 0.3446
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0078 0.0078
Schistosoma mansoni tsg101-related 0.0058 0.0582 0.0871
Trypanosoma cruzi DNA polymerase kappa, putative 0.0159 0.1846 0.4492
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.0175 0.0427
Trypanosoma cruzi DNA damage repair protein, putative 0.0033 0.0269 0.0648
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0055 0.0091
Brugia malayi Cell death protein 3 precursor 0.0026 0.0188 0.0188
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0222 0.0222
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0018 0.0025
Schistosoma mansoni DNA polymerase IV / kappa 0.0033 0.0269 0.0402
Trypanosoma brucei metacaspase 0.0026 0.0188 0.0451
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0188 0.0266
Echinococcus granulosus caspase 0.0026 0.0188 0.0188
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0055 0.0127
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0118 0.133 0.133
Loa Loa (eye worm) hypothetical protein 0.0081 0.0875 0.0903
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0118 0.133 0.133
Toxoplasma gondii small ubiquitin family modifier, putative 0.0031 0.0241 0.0587
Loa Loa (eye worm) hypothetical protein 0.0025 0.0175 0.0181
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.1039 0.1468
Schistosoma mansoni caspase-3 (C14 family) 0.0026 0.0188 0.0281
Echinococcus multilocularis peregrin 0.0039 0.0341 0.0341
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0999 0.1412
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0078 0.0078
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0025 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0081
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0091 0.0999 0.1412
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0055 0.0134
Schistosoma mansoni phosphoglycerate kinase 0.0339 0.4106 0.6145
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0339 0.4106 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0188 0.0266
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0999 0.1412
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0091 0.0999 0.0999
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.0175 0.0427
Brugia malayi bZIP transcription factor family protein 0.0084 0.0903 0.0903
Schistosoma mansoni tsg101-related 0.0047 0.0449 0.0672
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0026 0.0188 0.0281
Brugia malayi jmjC domain containing protein 0.0095 0.1052 0.1052
Echinococcus granulosus GPCR family 2 0.0031 0.0251 0.0251
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0078 0.0078
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0091 0.0999 0.0999
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0078 0.0117
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0251 0.0251
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0078 0.0117
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0026 0.0188 0.0188
Trichomonas vaginalis chromobox protein, putative 0.007 0.0729 0.103
Schistosoma mansoni hypothetical protein 0.0031 0.0251 0.0376
Toxoplasma gondii hypothetical protein 0.0066 0.0681 0.1659
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0078 0.0081
Trichomonas vaginalis hypothetical protein 0.0034 0.0281 0.0397
Entamoeba histolytica hypothetical protein 0.0012 0.0003 0.0004
Plasmodium vivax flap endonuclease 1, putative 0.0052 0.0507 0.1236
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0081
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0339 0.4106 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0106 0.1182 0.2841
Schistosoma mansoni gabp alpha 0.0072 0.0759 0.1137
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0081
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0025 0.0175 0.0248
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0091 0.0999 0.1032
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0078 0.0078
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.0175 0.0427
Trichomonas vaginalis chromobox protein, putative 0.007 0.0729 0.103
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0052 0.0507 0.123
Echinococcus multilocularis Small ubiquitin modifier 2 0.0031 0.0241 0.0241
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0999 0.1412
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0091 0.0999 0.2429
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0188 0.0266
Trypanosoma cruzi DNA damage repair protein, putative 0.0033 0.0269 0.0648
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0003 0.0004
Schistosoma mansoni hypothetical protein 0.0338 0.4087 0.6118
Brugia malayi Ubiquitin-like protein SMT3 0.0031 0.0241 0.0241
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0078 0.0078
Leishmania major DNA polymerase kappa, putative 0.0033 0.0269 0.0613
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0078 0.0078
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0188 0.0266
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0094 0.0141
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0078 0.0078
Brugia malayi glutaminase DH11.1 0.0545 0.6682 0.6682
Leishmania major small ubiquitin protein, putative 0.0031 0.0241 0.0546
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.1039 0.2525
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0251 0.0251
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0025 0.0175 0.0181
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0031 0.0241 0.0361
Onchocerca volvulus Cell death protein 3 homolog 0.0026 0.0188 0.17
Loa Loa (eye worm) hypothetical protein 0.0068 0.0708 0.0731
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0299 0.0309
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0078 0.0117
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0025 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0025 0.0175 0.0181
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0078 0.0117
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.0175 0.0427
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0383 0.0541
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0091 0.0999 0.1496
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0018 0.0036
Loa Loa (eye worm) RecQ helicase 0.0024 0.0158 0.0163
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0999 0.1412
Schistosoma mansoni 23-cyclic-nucleotide 2-phosphodiesterase 0.0293 0.3527 0.5279
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.0175 0.0427
Plasmodium vivax DNA repair protein REV1, putative 0.0033 0.0269 0.0654
Trypanosoma brucei DNA polymerase kappa, putative 0.0159 0.1846 0.4492
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0999 0.1412
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0442 0.0625
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0026 0.0188 0.0188
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.0175 0.0427
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0055 0.0127
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0427 0.0441
Schistosoma mansoni chromobox protein 0.007 0.0729 0.1091
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0159 0.1846 0.2608
Brugia malayi Bromodomain containing protein 0.0029 0.0222 0.0222
Schistosoma mansoni kinase 0.0048 0.0458 0.0685
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0999 0.1412
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0078 0.0117
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0025 0.0175 0.0248
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0018 0.0025
Trypanosoma brucei unspecified product 0.0146 0.1681 0.4091
Echinococcus multilocularis flap endonuclease 1 0.0052 0.0507 0.0507
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0999 0.1412
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0175 0.042
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.061 0.063
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0427 0.0427
Giardia lamblia Phosphoglycerate kinase 0.0339 0.4106 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.0175 0.0427
Trypanosoma brucei DNA polymerase kappa, putative 0.0159 0.1846 0.4492
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0025 0.0175 0.0175
Onchocerca volvulus 0.0018 0.0078 0.0629
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0091 0.0999 0.1412
Trypanosoma cruzi DNA polymerase eta, putative 0.0084 0.0904 0.2197
Echinococcus multilocularis dna polymerase kappa 0.0159 0.1846 0.1846
Trypanosoma brucei DNA polymerase kappa, putative 0.0159 0.1846 0.4492
Giardia lamblia PHD finger protein 15 0.0029 0.0222 0.0119
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0055 0.0134
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1102 0.1102
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0118 0.133 0.133
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0091 0.0999 0.1412
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0055 0.0081
Leishmania major hypothetical protein, conserved 0.0025 0.0171 0.0376
Leishmania major DNA damage repair protein, putative 0.0033 0.0269 0.0613
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0025 0.0175 0.0248
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0025 0.0175 0.0248
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1039 0.1468
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0025 0.0175 0.042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0078 0.0081
Mycobacterium ulcerans DNA polymerase IV 0.0159 0.1846 0.246
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0091 0.0999 0.1412
Brugia malayi ImpB/MucB/SamB family protein 0.0157 0.1818 0.1818
Entamoeba histolytica hypothetical protein 0.0036 0.0306 0.0432
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0175 0.042
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0055 0.0127
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0759 0.0784
Leishmania major DNA polymerase eta, putative 0.0084 0.0904 0.2169
Echinococcus granulosus caspase 8 0.0026 0.0188 0.0188
Brugia malayi ecdysteroid receptor 0.0018 0.0078 0.0078
Mycobacterium ulcerans putative regulatory protein 0.0066 0.0681 0.0644
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0078 0.0078
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0119 0.1347 0.3244
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0269 0.0648
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0078 0.0078
Plasmodium falciparum small ubiquitin-related modifier 0.0031 0.0241 0.0587
Trichomonas vaginalis glutaminase, putative 0.0545 0.6682 0.944
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0055 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0078 0.0078
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0999 0.1412
Loa Loa (eye worm) hypothetical protein 0.0039 0.0346 0.0357
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0158 0.0223
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0025 0.0175 0.0427
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0078 0.0081
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0999 0.1412
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0025 0.0175 0.0175
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0188 0.0458
Trypanosoma brucei small ubiquitin-related modifier 0.0031 0.0241 0.0581
Mycobacterium ulcerans glutaminase 0.0545 0.6682 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0159 0.1846 0.4492
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0759 0.0759
Leishmania major DNA polymerase kappa, putative 0.0119 0.1347 0.3251
Trypanosoma brucei metacaspase 5, putative 0.0026 0.0188 0.0451
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0025 0.0175 0.0427
Plasmodium vivax small ubiquitin-related modifier, putative 0.0031 0.0241 0.0587
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.0175 0.0427
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0025 0.0175 0.0262
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0188 0.0266
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0171 0.0417
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0078 0.0078
Brugia malayi nuclear hormone receptor 0.0018 0.0078 0.0078
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0025 0.0175 0.0427
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0175 0.042
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0025 0.0175 0.0175
Leishmania major hypothetical protein, conserved 0.0022 0.0136 0.0288
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.1347 0.3276
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0025 0.0175 0.0175
Toxoplasma gondii 5'-nucleotidase, C-terminal domain-containing protein 0.0121 0.1372 0.3342
Trypanosoma cruzi metacaspase, putative 0.0026 0.0188 0.0451
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0078 0.0078
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.0269 0.0648
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0251 0.0251
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0069 0.0727 0.0727
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0299 0.0447
Toxoplasma gondii hypothetical protein 0.0066 0.0681 0.1659
Trypanosoma cruzi DNA polymerase kappa, putative 0.0159 0.1846 0.4492
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0339 0.4106 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0383 0.3602
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0427 0.0427
Trypanosoma brucei DNA polymerase kappa, putative 0.0159 0.1846 0.4492
Plasmodium falciparum phosphoglycerate kinase 0.0339 0.4106 1
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0759 0.0759
Loa Loa (eye worm) hypothetical protein 0.0784 0.9682 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0427 0.0427
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0055 0.0134
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0025 0.0175 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0078 0.0078
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0175 0.042
Onchocerca volvulus 0.0031 0.024 0.2211
Echinococcus multilocularis jun protein 0.0084 0.0903 0.0903
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0055 0.0055
Giardia lamblia DNA damage repair protein 0.0033 0.0269 0.0237
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0018 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0346 0.0489
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0106 0.1182 0.1182
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0251 0.0259
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0078 0.0078
Brugia malayi Phosphoglycerate kinase 0.0125 0.1417 0.1417
Echinococcus multilocularis geminin 0.0338 0.4087 0.4087
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0046 0.0433 0.1055
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0025 0.0175 0.0248
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1039 0.1468
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0306 0.0306
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0025 0.0175 0.042
Loa Loa (eye worm) hypothetical protein 0.0069 0.0727 0.0751
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0999 0.1412
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0081
Loa Loa (eye worm) fli-1 protein 0.0219 0.2596 0.2681
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0084 0.0903 0.0903
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1039 0.1468
Echinococcus multilocularis caspase 8 0.0026 0.0188 0.0188
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1039 0.1468
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0121 0.0295
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0188 0.0451
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0055 0.0082
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0081
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0078 0.0078
Echinococcus multilocularis chromobox protein 1 0.007 0.0729 0.0729
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0025 0.0175 0.0175
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.1039 0.1039
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0052 0.0507 0.1236
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0106 0.1182 0.1221
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.1039 0.2525
Plasmodium falciparum phosphodiesterase delta, putative 0.0025 0.0175 0.0427
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0052 0.0507 0.123
Plasmodium vivax hypothetical protein, conserved 0.0066 0.0681 0.1659
Brugia malayi Ets-domain containing protein 0.0072 0.0759 0.0759
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0078 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0078 0.0078
Trypanosoma brucei unspecified product 0.0073 0.0771 0.1872
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0171 0.0411
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0175 0.0248
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0091 0.0999 0.2429
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0118 0.133 0.133
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0188 0.0266
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0188 0.0266
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.0932 0.2265
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.0936 0.2274
Trypanosoma brucei DNA damage repair protein, putative 0.0033 0.0269 0.0648
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0078 0.0117
Plasmodium falciparum metacaspase 1 0.0026 0.0188 0.0458
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0222 0.0332
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0339 0.4106 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0025 0.0175 0.042
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.0175 0.0427
Plasmodium vivax metacaspase 1, putative 0.0026 0.0188 0.0458
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0025 0.0175 0.0248
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0091 0.0999 0.2429
Onchocerca volvulus Protein ultraspiracle homolog 0.0018 0.0078 0.0629
Brugia malayi hypothetical protein 0.0025 0.0171 0.0171
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0025 0.0175 0.042
Onchocerca volvulus 0.0066 0.0679 0.6488
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0025 0.0175 0.0427
Trypanosoma cruzi metacaspase, putative 0.0026 0.0188 0.0451
Schistosoma mansoni coup transcription factor 0.0018 0.0078 0.0117
Trypanosoma cruzi DNA polymerase kappa, putative 0.0159 0.1846 0.4492
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0091 0.0999 0.1412
Plasmodium vivax phosphodiesterase gamma, putative 0.0025 0.0175 0.0427
Loa Loa (eye worm) hypothetical protein 0.0062 0.0629 0.0649
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0119 0.1347 0.3251
Echinococcus granulosus chromobox protein 1 0.007 0.0729 0.0729
Plasmodium falciparum GAF domain-related protein, putative 0.0066 0.0681 0.1659
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0251 0.0251
Schistosoma mansoni tsg101-related 0.0058 0.0582 0.0871
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0078 0.0078
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0025 0.0175 0.0248
Brugia malayi polk-prov protein 0.0086 0.0932 0.0932
Treponema pallidum phosphoglycerate kinase 0.0339 0.4106 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0222 0.0541
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.0175 0.0427
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0999 0.1412
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0299 0.0447
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.0932 0.2265
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0086 0.0932 0.0963
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0091 0.0999 0.1412
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0681 0.0963
Brugia malayi SET domain containing protein 0.0012 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0681 0.0963
Trypanosoma brucei polo-like protein kinase 0.0094 0.1039 0.2525
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0055 0.0127
Plasmodium falciparum DNA repair protein REV1, putative 0.0033 0.0269 0.0654
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1102 0.1102
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0033 0.0266 0.0266
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0022 0.0136 0.0323
Schistosoma mansoni terminal deoxycytidyl transferase 0.0106 0.1182 0.1769
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0078 0.0117
Schistosoma mansoni flap endonuclease-1 0.0047 0.0445 0.0666
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0055 0.0055
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0091 0.0999 0.1412
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0125 0.1417 0.3446
Leishmania major DNA polymerase eta, putative 0.0157 0.1818 0.4404
Echinococcus multilocularis GPCR, family 2 0.0031 0.0251 0.0251
Loa Loa (eye worm) glutaminase 0.0545 0.6682 0.6901
Schistosoma mansoni hypothetical protein 0.0031 0.0251 0.0376
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0427 0.0427
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0125 0.1417 0.3446
Echinococcus granulosus phosphoglycerate kinase 1 0.0339 0.4106 0.4106
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0299 0.0299
Echinococcus granulosus dna polymerase eta 0.0157 0.1818 0.1818
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0084 0.0904 0.2203
Schistosoma mansoni hypothetical protein 0.0029 0.0222 0.0332
Trypanosoma brucei chrX additional, unordered contigs 0.0033 0.0269 0.0648
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.1039 0.2498
Toxoplasma gondii 5'-nucleotidase, C-terminal domain-containing protein 0.0294 0.3538 0.8616
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0125 0.1417 0.3446
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0025 0.0175 0.0248
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0091 0.0999 0.0999
Trypanosoma brucei phosphoglycerate kinase 0.0125 0.1417 0.3446
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0091 0.0999 0.1412
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0299 0.0299
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1039 0.1468
Loa Loa (eye worm) flap endonuclease-1 0.0052 0.0507 0.0524
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0078 0.0078
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.0175 0.0427
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0091 0.0999 0.1412
Echinococcus granulosus bloom syndrome protein 0.0024 0.0158 0.0158
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0999 0.1412
Trypanosoma brucei DNA polymerase kappa, putative 0.0159 0.1846 0.4492
Mycobacterium ulcerans DNA polymerase IV 0.0159 0.1846 0.246
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0025 0.0175 0.0427
Trypanosoma brucei DNA damage repair protein, putative 0.0033 0.0269 0.0648
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0091 0.0999 0.1496
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0025 0.0175 0.0175
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0188 0.0458
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0091 0.0999 0.1412
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0175 0.0248
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0026 0.0188 0.0188
Brugia malayi PHD-finger family protein 0.0029 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0025 0.0171 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0203 0.0287
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0078 0.0081
Schistosoma mansoni caspase-7 (C14 family) 0.0026 0.0188 0.0281
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0066 0.0681 0.1614
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.0175 0.0427
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0025 0.0175 0.0262
Echinococcus granulosus flap endonuclease 1 0.0052 0.0507 0.0507
Trypanosoma brucei phosphoglycerate kinase, putative 0.0125 0.1417 0.3446
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0025 0.0175 0.0175
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0577 0.7078 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0078 0.0078
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0025 0.0175 0.0175
Trypanosoma brucei phosphoglycerate kinase 0.0339 0.4106 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0999 0.1412
Entamoeba histolytica hypothetical protein 0.0012 0.0003 0.0004
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0025 0.0175 0.0262
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0025 0.0175 0.042
Loa Loa (eye worm) hypothetical protein 0.0031 0.024 0.0248
Trypanosoma brucei DNA polymerase kappa, putative 0.0159 0.1846 0.4492
Loa Loa (eye worm) hypothetical protein 0.0026 0.0188 0.0194
Entamoeba histolytica hypothetical protein 0.0036 0.0306 0.0432
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0118 0.133 0.1374
Echinococcus granulosus peregrin 0.0039 0.0341 0.0341
Brugia malayi Phosphoglycerate kinase 0.0339 0.4106 0.4106
Entamoeba histolytica deoxycytidyl transferase, putative 0.0106 0.1182 0.167
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.0175 0.0427
Trypanosoma brucei DNA polymerase kappa, putative 0.0159 0.1846 0.4492
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0091 0.0999 0.1412
Echinococcus multilocularis phosphoglycerate kinase 1 0.0339 0.4106 0.4106
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0078 0.0117
Schistosoma mansoni hypothetical protein 0.0031 0.0251 0.0376
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0078 0.0078
Schistosoma mansoni hypothetical protein 0.0031 0.0251 0.0376
Schistosoma mansoni SET domain protein 0.0033 0.0266 0.0397
Plasmodium falciparum phosphodiesterase gamma, putative 0.0025 0.0175 0.0427
Loa Loa (eye worm) hypothetical protein 0.0025 0.0175 0.0181
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0081
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.1039 0.1039
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0577 0.7078 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0018 0.0078 0.0629
Leishmania major hypothetical protein, conserved 0.0025 0.0175 0.0385
Schistosoma mansoni jun-related protein 0.0068 0.0707 0.1059
Loa Loa (eye worm) hypothetical protein 0.0719 0.8858 0.9149
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0025 0.0175 0.0262
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0025 0.0175 0.042
Trypanosoma brucei phosphoglycerate kinase 0.0339 0.4106 1
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0025 0.0175 0.0175
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0188 0.0266
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.1052 0.1052
Giardia lamblia Sentrin 0.0031 0.0241 0.0167
Loa Loa (eye worm) hypothetical protein 0.0029 0.0222 0.0229
Trypanosoma brucei DNA polymerase kappa, putative 0.0159 0.1846 0.4492
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0055 0.0057
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0081
Loa Loa (eye worm) PDE1B protein 0.0025 0.0175 0.0181
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0078 0.0117
Loa Loa (eye worm) hypothetical protein 0.0339 0.4106 0.4241
Plasmodium falciparum flap endonuclease 1 0.0052 0.0507 0.1236
Onchocerca volvulus Alhambra homolog 0.0029 0.0222 0.2032
Trypanosoma cruzi DNA polymerase kappa, putative 0.0159 0.1846 0.4492
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0055 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0078 0.0078
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0025 0.0175 0.0175
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.0175 0.0427
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0025 0.0175 0.042
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0806 0.1207
Entamoeba histolytica ubiquitin like protein 0.0031 0.0241 0.0341
Brugia malayi steroid hormone receptor 0.0018 0.0078 0.0078
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0091 0.0999 0.1412
Schistosoma mansoni hypothetical protein 0.0068 0.0707 0.1059
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0125 0.1417 0.3446
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.0175 0.0427
Trypanosoma brucei metacaspase MCA3 0.0026 0.0188 0.0451
Schistosoma mansoni chromobox protein 0.007 0.0729 0.1091
Plasmodium falciparum metacaspase-like protein 0.0026 0.0188 0.0458
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0999 0.1412
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0022 0.0136 0.0323
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0171 0.0411
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0025 0.0175 0.0262
Echinococcus multilocularis chromobox protein 1 0.007 0.0729 0.0729
Chlamydia trachomatis phosphoglycerate kinase 0.0339 0.4106 0.5
Mycobacterium ulcerans phosphoglycerate kinase 0.0339 0.4106 0.5984
Trypanosoma brucei DNA polymerase eta, putative 0.0157 0.1818 0.4424
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0365 0.0365
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0055 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0346 0.0489
Trypanosoma cruzi metacaspase, putative 0.0026 0.0188 0.0451
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0175 0.042
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0058 0.0141
Brugia malayi hypothetical protein 0.0016 0.006 0.006
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0091 0.0999 0.1412
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0158 0.0223
Leishmania major hypothetical protein, conserved 0.0025 0.0175 0.0385
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0442 0.0625
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0106 0.1182 0.1182
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0339 0.4106 0.5
Brugia malayi Fli-1 protein 0.0219 0.2596 0.2596
Giardia lamblia Flap structure-specific endonuclease 0.0052 0.0507 0.0845
Entamoeba histolytica phosphoglycerate kinase, putative 0.0339 0.4106 0.5801
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.0175 0.0427
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0171 0.0417
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0118 0.133 0.199
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0078 0.0078
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.1039 0.1073
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0222 0.0541
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0251 0.0251
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0033 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0081
Entamoeba histolytica hypothetical protein 0.0036 0.0306 0.0432
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0427 0.0639
Entamoeba histolytica Flap nuclease, putative 0.0052 0.0507 0.0717
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.081 1 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0159 0.1846 0.2608
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0222 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0003 0.0004
Echinococcus multilocularis caspase 0.0026 0.0188 0.0188
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0171 0.0411
Brugia malayi isocitrate dehydrogenase 0.0016 0.0055 0.0055
Schistosoma mansoni DNA polymerase eta 0.0157 0.1818 0.2721
Loa Loa (eye worm) hypothetical protein 0.0026 0.0188 0.0194
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0339 0.4106 0.5801
Toxoplasma gondii hypothetical protein 0.0066 0.0681 0.1659
Trypanosoma cruzi small ubiquitin protein, putative 0.0031 0.0241 0.0581
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0091 0.0999 0.2429
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0708 0.0708
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0025 0.0175 0.0262
Entamoeba histolytica hypothetical protein 0.0036 0.0306 0.0432
Echinococcus granulosus caspase 2 0.0026 0.0188 0.0188
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1039 0.1468
Giardia lamblia Hypothetical protein 0.012 0.1362 0.3019
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0106 0.1182 0.1769
Loa Loa (eye worm) hypothetical protein 0.0121 0.1369 0.1414
Loa Loa (eye worm) SMO-1 protein 0.0031 0.0241 0.0249
Schistosoma mansoni 23-cyclic-nucleotide 2-phosphodiesterase 0.0294 0.3538 0.5295
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0078 0.0078
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0339 0.4106 1
Leishmania major metacaspase, putative 0.0026 0.0188 0.0416
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0025 0.0175 0.042
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.006 0.0147
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0069 0.0727 0.0727
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0025 0.0175 0.0427
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0203 0.0287
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0055 0.0134
Trypanosoma brucei Metacaspase-4 0.0026 0.0188 0.0451
Trypanosoma brucei metacaspase MCA2 0.0026 0.0188 0.0451
Trypanosoma brucei DNA polymerase IV, putative 0.0159 0.1846 0.4492
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0078 0.0078
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0025 0.0175 0.0175
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0078 0.0078
Brugia malayi nuclear receptor NHR-88 0.0018 0.0078 0.0078
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0078 0.0078
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0158 0.0158
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0078 0.0078
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0025 0.0175 0.0262
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0346 0.324
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0025 0.0175 0.0262
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0158 0.0158
Schistosoma mansoni hypothetical protein 0.0068 0.0708 0.106
Brugia malayi Ets-domain containing protein 0.0072 0.0759 0.0759
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0078 0.0081
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0188 0.0266
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0078 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0188 0.0266
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0188 0.0266
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0427 0.0639
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0365 0.0365
Echinococcus granulosus Small ubiquitin modifier 2 0.0031 0.0241 0.0241
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0251 0.0251
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1039 0.1468
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.0175 0.0427
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0078 0.0078
Brugia malayi Heterochromatin protein 1 0.007 0.0729 0.0729
Toxoplasma gondii GAF domain-containing protein 0.0066 0.0681 0.1659
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0427 0.0427
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0084 0.0903 0.0903
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0175 0.042
Brugia malayi hypothetical protein 0.0069 0.0727 0.0727
Schistosoma mansoni glutaminase 0.0545 0.6682 1
Onchocerca volvulus Bile acid receptor homolog 0.0018 0.0078 0.0629
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0047 0.0449 0.0634
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.0269 0.0648
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0014 0.002
Leishmania major phosphoglycerate kinase C, glycosomal 0.0339 0.4106 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0055 0.0055
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0025 0.0175 0.0427
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0078 0.0078
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.081 1 1
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0188 0.0451
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.0936 0.2274
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0188 0.0266
Leishmania major cAMP-specific phosphodiesterase, putative 0.0025 0.0175 0.0385
Loa Loa (eye worm) hypothetical protein 0.0157 0.1818 0.1878
Plasmodium falciparum phd finger protein, putative 0.0029 0.0222 0.0541
Schistosoma mansoni ets-related 0.0219 0.2596 0.3885
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0055 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0078 0.0078
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1102 0.1138
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0383 0.0541
Brugia malayi Flap endonuclease-1 0.0052 0.0507 0.0507
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0025 0.0175 0.042
Plasmodium vivax phosphoglycerate kinase, putative 0.0339 0.4106 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0078 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0188 0.0266
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0681 0.0963
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0188 0.0266
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0999 0.1412
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0269 0.0648
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0171 0.0417
Loa Loa (eye worm) glutaminase 2 0.0545 0.6682 0.6901
Leishmania major phosphoglycerate kinase B, cytosolic 0.0339 0.4106 1
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0125 0.1417 0.3422
Giardia lamblia DINP protein human, muc B family 0.0119 0.1347 0.2981
Entamoeba histolytica hypothetical protein 0.0012 0.0003 0.0004
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0078 0.0117
Trypanosoma brucei DNA polymerase IV, putative 0.0146 0.1681 0.4091
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0091 0.0999 0.1412
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0078 0.0078
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.1039 1
Brugia malayi chromobox protein homolog 3 0.0039 0.0346 0.0346
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0175 0.042
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.0936 0.2274
Schistosoma mansoni hypothetical protein 0.0338 0.4087 0.6118
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0306 0.0457
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0729 0.0753
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0681 0.0963
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.1039 0.1555
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0188 0.0458
Brugia malayi ImpB/MucB/SamB family protein 0.0106 0.1182 0.1182
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0339 0.4106 0.5801
Loa Loa (eye worm) hypothetical protein 0.0031 0.0251 0.0259
Brugia malayi hypothetical protein 0.0066 0.0679 0.0679
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0091 0.0999 0.1412
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0025 0.0175 0.0262
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0222 0.0222
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0091 0.0999 0.2429
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.0175 0.0248
Loa Loa (eye worm) hypothetical protein 0.0099 0.1102 0.1138
Echinococcus granulosus geminin 0.0338 0.4087 0.4087
Echinococcus multilocularis dna polymerase eta 0.0157 0.1818 0.1818
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0033 0.0269 0.0654
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0091 0.0999 0.1412
Trichomonas vaginalis flap endonuclease-1, putative 0.0052 0.0507 0.0717
Echinococcus granulosus chromobox protein 1 0.007 0.0729 0.0729
Trypanosoma brucei DNA polymerase IV, putative 0.0159 0.1846 0.4492

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.23 Induction of apoptosis in human T47D cells ChEMBL. 17870538
EC50 (functional) = 1.7 uM Effective concentration against human breast cancer T47D cell line apoptosis inducing activity was measured by using cell and caspase-based HTS assay ChEMBL. 16143530
EC50 (functional) = 1.7 uM Effective concentration against human breast cancer T47D cell line apoptosis inducing activity was measured by using cell and caspase-based HTS assay ChEMBL. 16143530
EC50 (functional) = 2.5 uM Effective concentration against human non-small cell lung cancer H1299 cells inducing apoptosis, activity was measured by cell and caspase-based HTS assay ChEMBL. 16143530
EC50 (functional) = 2.5 uM Effective concentration against human non-small cell lung cancer H1299 cells inducing apoptosis, activity was measured by cell and caspase-based HTS assay ChEMBL. 16143530
Log (1/C) (functional) = 5.77 Induction of apoptosis in human HL60 B cells ChEMBL. 17658263
log(1/EC50) (functional) = -0.23 Induction of apoptosis in human T47D cells ChEMBL. 17870538

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 16143530

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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