Detailed information for compound 346791

Basic information

Technical information
  • TDR Targets ID: 346791
  • Name: N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-[2-( 1,4-dimethylpiperidin-4-yl)-1,3-thiazol-4-yl] benzamide
  • MW: 479.638 | Formula: C26H33N5O2S
  • H donors: 2 H acceptors: 4 LogP: 3.79 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CCNC(=O)C1(CCCCC1)NC(=O)c1ccc(cc1)c1csc(n1)C1(C)CCN(CC1)C
  • InChi: 1S/C26H33N5O2S/c1-25(12-16-31(2)17-13-25)24-29-21(18-34-24)19-6-8-20(9-7-19)22(32)30-26(10-4-3-5-11-26)23(33)28-15-14-27/h6-9,18H,3-5,10-13,15-17H2,1-2H3,(H,28,33)(H,30,32)
  • InChiKey: NXSZCSJUPBDVTG-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-[2-(1,4-dimethyl-4-piperidyl)thiazol-4-yl]benzamide
  • N-[1-[(cyanomethylamino)-oxomethyl]cyclohexyl]-4-[2-(1,4-dimethyl-4-piperidinyl)-4-thiazolyl]benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Oryctolagus cuniculus Cathepsin K Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin K   329 aa 279 aa 28.0 %
Onchocerca volvulus Cathepsin K   329 aa 298 aa 31.9 %
Plasmodium vivax vivapain-3 Cathepsin K   329 aa 327 aa 35.5 %
Leishmania donovani cysteine peptidase C (CPC) Cathepsin K   329 aa 264 aa 29.9 %
Babesia bovis papain family cysteine protease containing protein Cathepsin K   329 aa 331 aa 32.3 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 363 aa 25.1 %
Plasmodium berghei berghepain-1 Cathepsin K   329 aa 345 aa 31.6 %
Babesia bovis cathepsin C precursor, putative Cathepsin K   329 aa 269 aa 25.3 %
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Cathepsin K   329 aa 270 aa 26.7 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin K   329 aa 264 aa 29.2 %
Echinococcus multilocularis cathepsin L Cathepsin K   329 aa 354 aa 37.3 %
Neospora caninum hypothetical protein Cathepsin K   329 aa 381 aa 24.9 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin K   329 aa 323 aa 34.4 %
Schistosoma mansoni SmCL2-like peptidase (C01 family) Cathepsin K   329 aa 318 aa 31.1 %
Echinococcus granulosus cathepsin L cysteine protease Cathepsin K   329 aa 328 aa 47.9 %
Trypanosoma cruzi cysteine proteinase, putative Cathepsin K   329 aa 333 aa 32.1 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 362 aa 25.1 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 326 aa 25.5 %
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) Cathepsin K   329 aa 319 aa 44.5 %
Schistosoma mansoni cathepsin S (C01 family) Cathepsin K   329 aa 309 aa 34.6 %
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin K   329 aa 264 aa 29.9 %
Theileria parva cysteine proteinase, putative Cathepsin K   329 aa 330 aa 28.5 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin K   329 aa 323 aa 34.4 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin K   329 aa 265 aa 26.4 %
Giardia lamblia Cathepsin L precursor Cathepsin K   329 aa 290 aa 31.4 %
Plasmodium falciparum cysteine proteinase falcipain 1 Cathepsin K   329 aa 348 aa 32.8 %
Schistosoma mansoni SmCB2 peptidase (C01 family) Cathepsin K   329 aa 290 aa 30.0 %
Trypanosoma cruzi cysteine proteinase, putative Cathepsin K   329 aa 333 aa 32.1 %
Giardia lamblia Cathepsin B precursor Cathepsin K   329 aa 299 aa 27.4 %
Dictyostelium discoideum hypothetical protein Cathepsin K   329 aa 349 aa 33.5 %
Onchocerca volvulus Cathepsin K   329 aa 319 aa 41.7 %
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Cathepsin K   329 aa 265 aa 26.0 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 380 aa 23.2 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin K   329 aa 268 aa 27.2 %
Brugia malayi Papain family cysteine protease containing protein Cathepsin K   329 aa 308 aa 32.1 %
Onchocerca volvulus Cathepsin K   329 aa 324 aa 40.7 %
Loa Loa (eye worm) hypothetical protein Cathepsin K   329 aa 277 aa 27.4 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 328 aa 27.7 %
Toxoplasma gondii cathepsin CPC1 Cathepsin K   329 aa 351 aa 23.6 %
Brugia malayi cathepsin B-like cysteine proteinase Cathepsin K   329 aa 375 aa 24.3 %
Babesia bovis cysteine protease 2 Cathepsin K   329 aa 343 aa 30.3 %
Echinococcus granulosus cathepsin b Cathepsin K   329 aa 268 aa 24.6 %
Onchocerca volvulus Cathepsin K   329 aa 310 aa 40.6 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin K   329 aa 268 aa 27.2 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 328 aa 25.9 %
Echinococcus multilocularis cathepsin L Cathepsin K   329 aa 316 aa 31.3 %
Plasmodium yoelii cathepsin c precursor Cathepsin K   329 aa 292 aa 23.3 %
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin K   329 aa 317 aa 26.5 %
Drosophila melanogaster CG6347 gene product from transcript CG6347-RA Cathepsin K   329 aa 305 aa 36.4 %
Onchocerca volvulus Cathepsin K   329 aa 272 aa 29.0 %
Plasmodium falciparum dipeptidyl aminopeptidase 2 Cathepsin K   329 aa 269 aa 27.1 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin K   329 aa 276 aa 26.4 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 363 aa 25.1 %
Plasmodium knowlesi dipeptidyl aminopeptidase 1, putative Cathepsin K   329 aa 277 aa 25.3 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin K   329 aa 299 aa 24.7 %
Dictyostelium discoideum cathepsin L-like proteinase Cathepsin K   329 aa 319 aa 37.9 %
Giardia lamblia Cathepsin B precursor Cathepsin K   329 aa 278 aa 28.8 %
Giardia lamblia Cathepsin L precursor Cathepsin K   329 aa 291 aa 33.7 %
Echinococcus granulosus cathepsin L Cathepsin K   329 aa 356 aa 37.4 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 369 aa 24.7 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 363 aa 25.1 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Schistosoma japonicum ko:K01365 cathepsin L [EC3.4.22.15], putative Cathepsin K   329 aa 322 aa 41.9 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin K   329 aa 268 aa 27.2 %
Echinococcus granulosus cathepsin L Cathepsin K   329 aa 316 aa 32.0 %
Plasmodium yoelii cysteine proteinase precursor Cathepsin K   329 aa 345 aa 29.9 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 310 aa 24.2 %
Echinococcus granulosus cysteine protease Cathepsin K   329 aa 328 aa 46.6 %
Toxoplasma gondii cathepsin B Cathepsin K   329 aa 290 aa 26.6 %
Onchocerca volvulus Cathepsin L homolog Cathepsin K   329 aa 316 aa 45.3 %
Theileria parva cysteine proteinase, putative Cathepsin K   329 aa 331 aa 26.9 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 296 aa 24.7 %
Theileria parva cysteine proteinase, putative Cathepsin K   329 aa 330 aa 32.1 %
Plasmodium knowlesi knowpain-1 Cathepsin K   329 aa 353 aa 28.6 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin K   329 aa 268 aa 27.2 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin K   329 aa 265 aa 26.8 %
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin K   329 aa 274 aa 27.7 %
Trypanosoma cruzi cysteine peptidase C (CPC), putative Cathepsin K   329 aa 264 aa 28.4 %
Trypanosoma cruzi cysteine peptidase C (CPC), putative Cathepsin K   329 aa 264 aa 28.8 %
Dictyostelium discoideum hypothetical protein Cathepsin K   329 aa 338 aa 34.9 %
Onchocerca volvulus Cathepsin K   329 aa 311 aa 37.3 %
Trypanosoma brucei cysteine peptidase C (CPC) Cathepsin K   329 aa 270 aa 26.7 %
Onchocerca volvulus Protein MCM10 homolog Cathepsin K   329 aa 302 aa 35.4 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 351 aa 24.8 %
Schistosoma japonicum Disco-interacting protein 2 homolog B, putative Cathepsin K   329 aa 342 aa 36.5 %
Trypanosoma cruzi cysteine protease, putative Cathepsin K   329 aa 318 aa 31.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cathepsin L-like precursor 0.0059 0.008 0.008
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0176 0.0603 0.1285
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.011 0.031 0.0232
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0071 0.0134 0.0134
Brugia malayi Trypsin family protein 0.011 0.031 0.031
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.011 0.031 0.031
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.2274 1 1
Onchocerca volvulus 0.0059 0.008 0.0227
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.107 0.4607 0.4503
Echinococcus granulosus glycoprotein Antigen 5 0.011 0.031 0.031
Echinococcus granulosus thymidylate synthase 0.0176 0.0603 0.0603
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.1746 0.7634 0.7482
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.011 0.031 0.031
Onchocerca volvulus 0.0059 0.008 0.0227
Brugia malayi Trypsin family protein 0.011 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.011 0.031 0.031
Schistosoma mansoni cercarial elastase (S01 family) 0.011 0.031 0.031
Echinococcus granulosus transmembrane protease serine 3 0.011 0.031 0.031
Brugia malayi Cathepsin L-like precursor 0.0059 0.008 0.008
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.1746 0.7634 1
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.008 0.008
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.011 0.031 0.031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.008 0.4195
Echinococcus granulosus dihydrofolate reductase 0.2274 1 1
Brugia malayi Trypsin family protein 0.011 0.031 0.031
Echinococcus multilocularis thymidylate synthase 0.0176 0.0603 0.0527
Schistosoma mansoni cercarial elastase (S01 family) 0.011 0.031 0.031
Schistosoma mansoni cercarial elastase (S01 family) 0.011 0.031 0.031
Onchocerca volvulus Cathepsin F homolog 0.0059 0.008 0.0227
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.008 0.4195
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.1746 0.7634 0.5
Giardia lamblia Cathepsin B precursor 0.0065 0.0106 0.5
Mycobacterium ulcerans thymidylate synthase 0.0176 0.0603 0.0302
Trypanosoma brucei cysteine peptidase C (CPC) 0.0065 0.0106 0.0056
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.1089 0.4695 1
Loa Loa (eye worm) cysteine protease 0.0059 0.008 0.008
Brugia malayi Cathepsin L-like precursor 0.0059 0.008 0.008
Echinococcus granulosus Mastin 0.011 0.031 0.031
Onchocerca volvulus 0.011 0.031 0.0882
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.011 0.031 0.0232
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.008 0.4195
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.008 0.4195
Brugia malayi hypothetical protein 0.011 0.031 0.031
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0065 0.0106 0.0225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.008 0.4195
Onchocerca volvulus 0.0059 0.008 0.0227
Onchocerca volvulus 0.0059 0.008 0.0227
Echinococcus granulosus cathepsin L cysteine proteinase 0.0059 0.008 0.008
Toxoplasma gondii cathepsin B 0.0065 0.0106 0.0034
Brugia malayi Papain family cysteine protease containing protein 0.0059 0.008 0.008
Brugia malayi Cathepsin L-like precursor 0.0059 0.008 0.008
Schistosoma mansoni cercarial elastase (S01 family) 0.011 0.031 0.031
Loa Loa (eye worm) dihydrofolate reductase 0.2274 1 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.011 0.031 0.031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.008 0.4195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.008 0.4195
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.011 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.0176 0.0603 0.0603
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.0603 0.0603
Echinococcus multilocularis dihydrofolate reductase 0.2274 1 1
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.1746 0.7634 1
Echinococcus multilocularis enteropeptidase 0.011 0.031 0.0232
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.008 0.4195
Brugia malayi cathepsin B-like cysteine proteinase 0.0176 0.0603 0.0603
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0176 0.0603 0.0603
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.019 1
Echinococcus multilocularis glycoprotein Antigen 5 0.011 0.031 0.0232
Loa Loa (eye worm) trypsin family protein 0.011 0.031 0.031
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.011 0.031 0.031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.008 0.4195
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0176 0.0603 0.042
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0176 0.0603 0.0603
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.1746 0.7634 0.7558
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0065 0.0106 0.0056
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.011 0.031 0.031
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.008 1
Schistosoma mansoni cercarial elastase (S01 family) 0.011 0.031 0.031
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.008 0.017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.008 0.4195
Onchocerca volvulus 0.0827 0.3521 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0059 0.008 0.4195
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0059 0.008 0.4195
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.008 0.4195
Loa Loa (eye worm) hypothetical protein 0.011 0.031 0.031
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0059 0.008 0.008
Onchocerca volvulus Cathepsin L homolog 0.0059 0.008 0.0227
Schistosoma mansoni hypothetical protein 0.011 0.031 0.031
Schistosoma mansoni cercarial elastase (S01 family) 0.011 0.031 0.031
Brugia malayi Dihydrofolate reductase 0.2274 1 1
Chlamydia trachomatis dihydrofolate reductase 0.2274 1 1
Brugia malayi thymidylate synthase 0.0176 0.0603 0.0603
Onchocerca volvulus Cathepsin L homolog 0.0059 0.008 0.0227
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.1746 0.7634 0.5
Brugia malayi Cathepsin L-like precursor 0.0059 0.008 0.008
Onchocerca volvulus 0.0059 0.008 0.0227
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.008 0.017
Schistosoma mansoni hypothetical protein 0.011 0.031 0.031
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0059 0.008 0.008
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.2274 1 1
Echinococcus multilocularis cathepsin b 0.0176 0.0603 0.0528
Echinococcus granulosus cathepsin l1 0.0059 0.008 0.008
Loa Loa (eye worm) ctsf protein 0.0059 0.008 0.008
Brugia malayi Cathepsin L-like precursor 0.0059 0.008 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.008 0.4195
Schistosoma mansoni cercarial elastase (S01 family) 0.011 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.0827 0.3521 0.3521
Onchocerca volvulus 0.0059 0.008 0.0227
Giardia lamblia Cathepsin B precursor 0.0065 0.0106 0.5
Loa Loa (eye worm) fibroinase 0.0059 0.008 0.008
Echinococcus granulosus cathepsin b 0.0176 0.0603 0.0603
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.008 0.4195
Giardia lamblia Cathepsin B precursor 0.0065 0.0106 0.5
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0827 0.3521 0.3521
Leishmania major dihydrofolate reductase-thymidylate synthase 0.1089 0.4695 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0065 0.0106 0.5556
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0065 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.011 0.031 0.031
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0084 0.019 0.0405
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.1089 0.4695 1
Echinococcus multilocularis Mastin 0.011 0.031 0.0232
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.008 0.017
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.0603 0.0603
Onchocerca volvulus 0.0059 0.008 0.0227
Brugia malayi Trypsin family protein 0.0827 0.3521 0.3521
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.011 0.031 0.031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.008 0.4195
Echinococcus granulosus cathepsin b 0.0176 0.0603 0.0603
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.2274 1 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.008 0.008
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.1746 0.7634 1
Trypanosoma cruzi cruzipain precursor, putative 0.0059 0.008 0.017
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.011 0.031 0.031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.008 0.4195
Onchocerca volvulus 0.011 0.031 0.0882
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.008 0.4195
Entamoeba histolytica cysteine protease, putative 0.0059 0.008 1
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.1089 0.4695 0.6109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.008 0.4195
Schistosoma mansoni cercarial elastase (S01 family) 0.011 0.031 0.031
Echinococcus granulosus cathepsin l cysteine peptidase 0.0059 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.011 0.031 0.031
Onchocerca volvulus 0.011 0.031 0.0882
Loa Loa (eye worm) hypothetical protein 0.0827 0.3521 0.3521
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0827 0.3521 0.3521
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.008 0.4195
Loa Loa (eye worm) hypothetical protein 0.011 0.031 0.031
Onchocerca volvulus 0.0176 0.0603 0.1712
Echinococcus multilocularis transmembrane protease serine 3 0.011 0.031 0.0232
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.008 0.4195
Schistosoma mansoni cercarial elastase (S01 family) 0.011 0.031 0.031
Schistosoma mansoni dihydrofolate reductase 0.2274 1 1
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.1089 0.4695 0.6109
Brugia malayi Trypsin-like protease protein 5 0.011 0.031 0.031
Echinococcus granulosus enteropeptidase 0.011 0.031 0.031
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.008 1
Schistosoma mansoni cercarial elastase (S01 family) 0.011 0.031 0.031
Onchocerca volvulus 0.011 0.031 0.0882
Onchocerca volvulus 0.0717 0.3027 0.8596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.008 0.4195
Echinococcus multilocularis cathepsin b 0.0176 0.0603 0.0528
Brugia malayi hypothetical protein 0.0084 0.019 0.019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.008 0.4195
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.008 0.008
Schistosoma mansoni cercarial elastase (S01 family) 0.011 0.031 0.031
Loa Loa (eye worm) cathepsin B 0.0065 0.0106 0.0106
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.008 0.4195
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.1089 0.4695 0.6109
Loa Loa (eye worm) thymidylate synthase 0.0176 0.0603 0.0603
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.008 0.4195
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.0603 0.0603
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.008 0.017
Onchocerca volvulus 0.011 0.031 0.0882

Activities

Activity type Activity value Assay description Source Reference
beta t1/2 (functional) = 137 min Terminal half-life in rat administered with 0.5 mg/kg, iv ChEMBL. 16302794
Cmax (functional) = 0.44 uM Maximum concentration in rat administered with 0.5 mg/kg, iv ChEMBL. 16302794
IC50 (functional) = 0.046 uM In vitro bone resorption in isolated rabbit osteoclasts ChEMBL. 16302794
Ki (binding) = 0.00095 uM Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrate ChEMBL. 16302794
Ki (binding) = 1.1 uM Inhibitory constant against human cathepsin B using Boc-Leu-Lys-Arg-AMC substrate ChEMBL. 16302794
Ki (binding) = 7.6 uM Inhibitory constant against human cathepsin L using Z-Phe-Arg-AMC substrate ChEMBL. 16302794
Ki (binding) = 30 uM Inhibitory constant against human cathepsin S using Z-Val-Val-Arg-AMC substrate ChEMBL. 16302794
Ki app (binding) = 0.00095 uM Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrate ChEMBL. 16302794
Ki app (binding) = 1.1 uM Inhibitory constant against human cathepsin B using Boc-Leu-Lys-Arg-AMC substrate ChEMBL. 16302794
Ki app (binding) = 7.6 uM Inhibitory constant against human cathepsin L using Z-Phe-Arg-AMC substrate ChEMBL. 16302794
Ki app (binding) = 30 uM Inhibitory constant against human cathepsin S using Z-Val-Val-Arg-AMC substrate ChEMBL. 16302794
MRT (functional) = 140 min Mean residence time in rat administered with 0.5 mg/kg, iv ChEMBL. 16302794

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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