TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 370.396 | Formula: C21H22O6
H donors: 1 H acceptors: 2 LogP: 5 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(O)c2c(c1CC=C(C)C)oc1c(c2=O)c(OC)c(cc1)OC
InChi: 1S/C21H22O6/c1-11(2)6-7-12-16(25-4)10-13(22)17-19(23)18-14(27-20(12)17)8-9-15(24-3)21(18)26-5/h6,8-10,22H,7H2,1-5H3
InChiKey: KVJGUAPUDHKYNI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.012	0.0287	1
Loa Loa (eye worm)	hypothetical protein	0.0501	0.1452	1
Schistosoma mansoni	amyloid beta A4 protein related	0.0069	0.0129	0.0875
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0147	0.0367	0.1742
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0047	0.0063	0.0063
Toxoplasma gondii	PAN domain-containing protein	0.0126	0.0303	0.0966
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0022	0.015
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0035	0.0026	0.0153
Loa Loa (eye worm)	pyruvate kinase	0.0034	0.0022	0.015
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0104	0.0235	0.0235
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0028	0.0269
Loa Loa (eye worm)	patched family protein	0.003	0.0011	0.0074
Loa Loa (eye worm)	hypothetical protein	0.009	0.0193	0.1332
Brugia malayi	hypothetical protein	0.003	0.0011	0.0074
Brugia malayi	glutathione reductase	0.0047	0.0063	0.0435
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0035	0.0026	0.0546
Loa Loa (eye worm)	glutathione reductase	0.0047	0.0063	0.0435
Mycobacterium ulcerans	acyl-CoA synthetase	0.0035	0.0026	0.0903
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0063	0.0112	0.0769
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.012	0.0286	0.9985
Brugia malayi	Cytochrome P450 family protein	0.0027	0	0.0002
Entamoeba histolytica	hypothetical protein	0.0147	0.0367	0.2395
Echinococcus multilocularis	protein patched	0.0215	0.0575	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0235	0.1618
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0063	0.0112	0.053
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0108	0.0249	0.8643
Toxoplasma gondii	PAN domain-containing protein	0.105	0.3132	1
Leishmania major	hypothetical protein, conserved	0.0051	0.0074	0.0724
Brugia malayi	Patched family protein	0.003	0.0011	0.0074
Brugia malayi	Patched related family protein 10	0.003	0.0011	0.0074
Onchocerca volvulus		0.0035	0.0026	0.018
Brugia malayi	AMP-binding enzyme family protein	0.012	0.0287	0.1973
Brugia malayi	Patched family protein	0.003	0.0011	0.0074
Onchocerca volvulus	Pyruvate kinase homolog	0.0034	0.0022	0.015
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0104	0.0235	0.1595
Brugia malayi	PAN domain containing protein	0.0126	0.0303	0.2084
Brugia malayi	Trypsin family protein	0.0104	0.0235	0.1618
Onchocerca volvulus	Protein patched homolog	0.003	0.0011	0.0074
Echinococcus multilocularis	sodium channel protein	0.0041	0.0043	0.0043
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0147	0.0367	0.0367
Onchocerca volvulus		0.0104	0.0235	0.1618
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0035	0.0026	0.0546
Mycobacterium leprae	POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0035	0.0026	0.0371
Brugia malayi	hypothetical protein	0.0051	0.0074	0.0508
Echinococcus multilocularis	pyruvate kinase	0.0034	0.0022	0.0022
Toxoplasma gondii	subtilisin SUB12	0.0126	0.0303	0.0966
Onchocerca volvulus		0.0104	0.0235	0.1618
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0074	0.0724
Brugia malayi	Patched family protein	0.003	0.0011	0.0074
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0501	0.1452	0.9862
Brugia malayi	Patched family protein	0.003	0.0011	0.0074
Mycobacterium ulcerans	acyl-CoA synthetase	0.0035	0.0026	0.0903
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0096	0.0213	0.0213
Loa Loa (eye worm)	PAN domain-containing protein	0.0126	0.0303	0.2084
Schistosoma mansoni	cercarial elastase (S01 family)	0.0104	0.0235	0.1595
Echinococcus multilocularis	voltage dependent calcium channel	0.0096	0.0213	0.0213
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Plasmodium vivax	thioredoxin reductase, putative	0.0047	0.0063	0.0521
Echinococcus multilocularis	pyruvate kinase	0.0034	0.0022	0.0022
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0035	0.0026	0.0255
Onchocerca volvulus		0.003	0.0011	0.0074
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0035	0.0026	0.0255
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Loa Loa (eye worm)	inositol-1	0.0036	0.0028	0.019
Echinococcus granulosus	voltage dependent calcium channel	0.0096	0.0213	0.1012
Mycobacterium ulcerans	acyl-CoA synthetase	0.012	0.0287	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0074	0.0724
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0035	0.0026	0.0903
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0104	0.0235	0.1595
Echinococcus multilocularis	tissue type plasminogen activator	0.0359	0.1016	0.1016
Loa Loa (eye worm)	pyruvate kinase	0.0034	0.0022	0.015
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0034	0.0022	0.015
Toxoplasma gondii	hypothetical protein	0.0126	0.0303	0.0966
Brugia malayi	Patched related family protein 12	0.003	0.0011	0.0074
Schistosoma mansoni	pyruvate kinase	0.0034	0.0022	0.0148
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0035	0.0026	0.0255
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0063	0.0112	0.0769
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0112	0.0769
Schistosoma mansoni	hypothetical protein	0.0104	0.0235	0.1595
Echinococcus multilocularis	Niemann Pick C1 protein	0.05	0.1449	0.1449
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0096	0.0213	0.1467
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0035	0.0026	0.0546
Toxoplasma gondii	patched family protein	0.003	0.0011	0.0034
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0028	0.5
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0028	0.0088
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0501	0.1452	0.9862
Brugia malayi	AMP-binding enzyme family protein	0.0035	0.0026	0.018
Schistosoma mansoni	voltage-gated cation channel	0.0096	0.0213	0.1447
Trichomonas vaginalis	antibiotic synthetase, putative	0.0035	0.0026	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0501	0.1452	1
Brugia malayi	protein C24B5.3	0.003	0.0011	0.0074
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0074	0.0628
Onchocerca volvulus		0.003	0.0011	0.0074
Brugia malayi	PAN domain containing protein	0.0126	0.0303	0.2084
Mycobacterium ulcerans	acyl-CoA synthetase	0.0035	0.0026	0.0903
Toxoplasma gondii	patched family protein	0.003	0.0011	0.0034
Brugia malayi	Patched family protein	0.003	0.0011	0.0074
Mycobacterium tuberculosis	Probable dehydrogenase	0.0108	0.0249	0.8643
Loa Loa (eye worm)	hypothetical protein	0.012	0.0287	0.1973
Onchocerca volvulus		0.0104	0.0235	0.1618
Brugia malayi	RNA binding protein	0.0064	0.0115	0.0793
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Loa Loa (eye worm)	patched family protein	0.003	0.0011	0.0074
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0035	0.0026	0.0903
Onchocerca volvulus		0.0126	0.0303	0.2084
Toxoplasma gondii	microneme protein MIC4	0.0126	0.0303	0.0966
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0035	0.0026	0.0903
Brugia malayi	Patched family protein	0.003	0.0011	0.0074
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0104	0.0235	0.1116
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Echinococcus multilocularis	expressed conserved protein	0.047	0.1356	0.1356
Onchocerca volvulus	Pyruvate kinase homolog	0.0034	0.0022	0.015
Brugia malayi	hypothetical protein	0.0066	0.0121	0.0831
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0096	0.0213	0.1012
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0028	0.2813
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0028	0.0106
Trichomonas vaginalis	conserved hypothetical protein	0.0215	0.0575	1
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0035	0.0026	0.0255
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0104	0.0235	0.1595
Echinococcus multilocularis	protein dispatched 1	0.0245	0.0668	0.0668
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Schistosoma mansoni	hypothetical protein	0.0207	0.0551	0.3743
Loa Loa (eye worm)	hypothetical protein	0.012	0.0287	0.1973
Toxoplasma gondii	PAN domain-containing protein	0.0126	0.0303	0.0966
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0028	0.0955
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Brugia malayi	Niemann-Pick C1 protein precursor	0.05	0.1449	0.9976
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0235	0.1618
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.012	0.0286	0.9985
Brugia malayi	Inositol-1	0.0036	0.0028	0.019
Onchocerca volvulus		0.0126	0.0303	0.2084
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0028	0.0188
Schistosoma mansoni	cercarial elastase (S01 family)	0.0104	0.0235	0.1595
Loa Loa (eye worm)	hypothetical protein	0.02	0.053	0.3652
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0126	0.0303	0.0966
Loa Loa (eye worm)	hypothetical protein	0.009	0.0193	0.1332
Echinococcus granulosus	Niemann Pick C1 protein	0.0714	0.2105	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0035	0.0026	0.018
Leishmania major	trypanothione reductase	0.0047	0.0063	0.0619
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0035	0.0026	0.0546
Toxoplasma gondii	microneme protein MIC17A	0.0126	0.0303	0.0966
Brugia malayi	AMP-binding enzyme family protein	0.0035	0.0026	0.018
Echinococcus granulosus	enteropeptidase	0.0104	0.0235	0.1116
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0074	0.0508
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0337	0.2318
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0028	0.0188
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0035	0.0026	0.0546
Mycobacterium ulcerans	acyl-CoA synthetase	0.0035	0.0026	0.0903
Brugia malayi	Latrophilin receptor protein 2	0.0063	0.0112	0.0769
Schistosoma mansoni	cercarial elastase (S01 family)	0.0104	0.0235	0.1595
Loa Loa (eye worm)	calcium channel	0.0096	0.0213	0.1467
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.012	0.0287	1
Schistosoma mansoni	hypothetical protein	0.0063	0.0112	0.0759
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Echinococcus multilocularis	amyloid beta A4 protein	0.0069	0.0129	0.0129
Brugia malayi	TAR-binding protein	0.0064	0.0115	0.0793
Onchocerca volvulus		0.0126	0.0303	0.2084
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0115	0.0782
Brugia malayi	hypothetical protein	0.0147	0.0367	0.2526
Schistosoma mansoni	hypothetical protein	0.0207	0.0551	0.3743
Toxoplasma gondii	pyruvate kinase PyK1	0.0034	0.0022	0.007
Loa Loa (eye worm)	hypothetical protein	0.009	0.0193	0.1332
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.009	0.0193	0.6744
Toxoplasma gondii	microneme protein MIC17C	0.0126	0.0303	0.0966
Toxoplasma gondii	PAN domain-containing protein	0.0126	0.0303	0.0966
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0226	0.1556
Schistosoma mansoni	patched 1	0.0215	0.0575	0.3904
Echinococcus granulosus	survival motor neuron protein 1	0.024	0.0654	0.3107
Echinococcus granulosus	transmembrane protease serine 3	0.0104	0.0235	0.1116
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.009	0.0193	0.6617
Mycobacterium ulcerans	acyl-CoA synthetase	0.012	0.0287	1
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0035	0.0026	0.0546
Loa Loa (eye worm)	PAN domain-containing protein	0.0126	0.0303	0.2084
Echinococcus granulosus	thioredoxin glutathione reductase	0.0047	0.0063	0.03
Onchocerca volvulus		0.0035	0.0026	0.018
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0026	0.018
Mycobacterium tuberculosis	Probable reductase	0.0108	0.0249	0.8643
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0126	0.0303	0.0966
Echinococcus multilocularis	survival motor neuron protein 1	0.024	0.0654	0.0654
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0035	0.0026	0.018
Onchocerca volvulus		0.0126	0.0303	0.2084
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0085	0.0178	0.6071
Onchocerca volvulus		0.0104	0.0235	0.1618
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Schistosoma mansoni	hypothetical protein	0.0063	0.0112	0.0759
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.0115	0.0793
Brugia malayi	PAN domain containing protein	0.0126	0.0303	0.2084
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0032	0.0016	0.0182
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.012	0.0287	1
Onchocerca volvulus		0.003	0.0011	0.0074
Brugia malayi	Patched protein homolog 1	0.003	0.0011	0.0074
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0104	0.0235	0.0235
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.05	0.1449	1
Loa Loa (eye worm)	thioredoxin reductase	0.0047	0.0063	0.0435
Trypanosoma cruzi	hypothetical protein, conserved	0.0359	0.1016	1
Loa Loa (eye worm)	X11 protein	0.0069	0.0129	0.0887
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0104	0.0235	0.1595
Mycobacterium leprae	POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE)	0.0035	0.0026	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0575	0.3959
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0303	0.2084
Brugia malayi	PAN domain containing protein	0.0126	0.0303	0.2084
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Plasmodium falciparum	cysteine repeat modular protein 1	0.0359	0.1016	1
Echinococcus multilocularis	sterol regulatory element binding protein	0.0215	0.0575	0.0575
Onchocerca volvulus		0.0126	0.0303	0.2084
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0041	0.0043	0.0205
Onchocerca volvulus	Huntingtin homolog	0.0127	0.0307	0.2117
Plasmodium falciparum	pyruvate kinase	0.0034	0.0022	0.011
Schistosoma mansoni	cercarial elastase (S01 family)	0.0104	0.0235	0.1595
Onchocerca volvulus		0.0126	0.0303	0.2084
Brugia malayi	AMP-binding enzyme family protein	0.0035	0.0026	0.018
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.012	0.0287	1
Onchocerca volvulus		0.0398	0.1135	0.7817
Schistosoma mansoni	acetyl-CoA synthetase	0.0035	0.0026	0.0178
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0035	0.0026	0.0903
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0108	0.0249	0.8617
Mycobacterium ulcerans	acyl-CoA synthetase	0.012	0.0287	1
Loa Loa (eye worm)	trypsin family protein	0.0104	0.0235	0.1618
Toxoplasma gondii	propionate-CoA ligase	0.0035	0.0026	0.0084
Plasmodium falciparum	acyl-CoA synthetase	0.009	0.0193	0.1817
Brugia malayi	Patched family protein	0.003	0.0011	0.0074
Echinococcus granulosus	Niemann Pick C1 protein	0.05	0.1449	0.688
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0034	0.0022	0.0212
Entamoeba histolytica	acyl-CoA synthetase, putative	0.012	0.0287	0.183
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.02	0.053	0.3652
Mycobacterium ulcerans	pyruvate kinase	0.0034	0.0022	0.0751
Echinococcus granulosus	tumor protein p63	0.0687	0.2022	0.9604
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.012	0.0286	0.9984
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0028	0.0131
Schistosoma mansoni	cercarial elastase (S01 family)	0.0104	0.0235	0.1595
Brugia malayi	PAN domain containing protein	0.0126	0.0303	0.2084
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0108	0.0249	0.8643
Echinococcus multilocularis	Tolloid protein 1	0.0027	0.0000082373	0.0000082373
Plasmodium vivax	pyruvate kinase, putative	0.0034	0.0022	0.011
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.0068	0.0469
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Onchocerca volvulus	Huntingtin homolog	0.0127	0.0307	0.2117
Plasmodium vivax	ataxin-2 like protein, putative	0.0051	0.0074	0.0628
Brugia malayi	Myosin head containing protein	0.003	0.0011	0.0074
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0035	0.0026	0.0026
Loa Loa (eye worm)	pyruvate kinase	0.0034	0.0022	0.015
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0028	0.0106
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0034	0.0022	0.0388
Brugia malayi	Thioredoxin reductase	0.0047	0.0063	0.0435
Onchocerca volvulus		0.012	0.0287	0.1973
Brugia malayi	hypothetical protein	0.0033	0.0019	0.0128
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0035	0.0026	0.2661
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0035	0.0026	0.0903
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0035	0.0026	0.0903
Toxoplasma gondii	LsmAD domain-containing protein	0.0051	0.0074	0.0236
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0096	0.0213	0.0213
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0034	0.0022	0.015
Brugia malayi	hypothetical protein	0.024	0.0654	0.4505
Schistosoma mansoni	hypothetical protein	0.0049	0.0068	0.0463
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0035	0.0026	0.2661
Entamoeba histolytica	hypothetical protein	0.0147	0.0367	0.2395
Brugia malayi	PAN domain containing protein	0.0126	0.0303	0.2084
Onchocerca volvulus		0.0049	0.0068	0.0469
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0096	0.0213	0.1012
Toxoplasma gondii	PAN domain-containing protein	0.0126	0.0303	0.0966
Brugia malayi	PAN domain containing protein	0.0126	0.0303	0.2084
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0307	0.2117
Loa Loa (eye worm)	cytochrome P450 family protein	0.0027	0	0.0002
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.0115	0.0793
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0235	0.1618
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0115	0.0782
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Brugia malayi	hypothetical protein	0.003	0.0011	0.0074
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	0.0035	0.0026	0.0371
Schistosoma mansoni	survival motor neuron protein	0.0049	0.0068	0.0463
Loa Loa (eye worm)	hypothetical protein	0.009	0.0193	0.1332
Loa Loa (eye worm)	cytochrome P450 family protein	0.0057	0.0092	0.0633
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0035	0.0026	0.0084
Giardia lamblia	Pyruvate kinase	0.0034	0.0022	0.5
Onchocerca volvulus		0.0126	0.0303	0.2084
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0026	0.018
Brugia malayi	hypothetical protein	0.0127	0.0307	0.2117
Leishmania major	pyruvate kinase	0.0034	0.0022	0.0212
Onchocerca volvulus		0.003	0.0011	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0303	0.2084
Loa Loa (eye worm)	hypothetical protein	0.009	0.0193	0.1332
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0035	0.0026	0.0255
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0035	0.0026	0.018
Loa Loa (eye worm)	RNA binding protein	0.0064	0.0115	0.0793
Plasmodium falciparum	glutathione reductase	0.0047	0.0063	0.0521
Loa Loa (eye worm)	patched family protein	0.003	0.0011	0.0074
Echinococcus multilocularis	Mastin	0.0104	0.0235	0.0235
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0028	0.0269
Entamoeba histolytica	hypothetical protein	0.0147	0.0367	0.2395
Brugia malayi	PAN domain containing protein	0.0126	0.0303	0.2084
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0028	0.001
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0215	0.0575	0.3959
Leishmania major	hypothetical protein, conserved	0.0359	0.1016	1
Echinococcus multilocularis	enteropeptidase	0.0104	0.0235	0.0235
Plasmodium falciparum	thioredoxin reductase	0.0047	0.0063	0.0521
Echinococcus multilocularis	voltage dependent calcium channel	0.0096	0.0213	0.0213
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0104	0.0235	0.1116
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Echinococcus granulosus	sterol regulatory element binding protein	0.0215	0.0575	0.273
Onchocerca volvulus		0.0039	0.0038	0.0259
Echinococcus granulosus	Mastin	0.0104	0.0235	0.1116
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0121	0.0831
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0035	0.0026	0.018
Toxoplasma gondii	hypothetical protein	0.003	0.0011	0.0034
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.012	0.0287	1
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0096	0.0213	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0303	0.2084
Toxoplasma gondii	microneme protein MIC17B	0.0126	0.0303	0.0966
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Brugia malayi	AMP-binding enzyme family protein	0.012	0.0287	0.1973
Loa Loa (eye worm)	PAN domain-containing protein	0.0126	0.0303	0.2084
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0035	0.0026	0.0546
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0028	0.0106
Toxoplasma gondii	microneme protein, putative	0.0126	0.0303	0.0966
Loa Loa (eye worm)	hypothetical protein	0.0359	0.1016	0.6995
Echinococcus multilocularis	laminin	0.0027	0.0000082373	0.0000082373
Brugia malayi	protein C24B5.3	0.003	0.0011	0.0074
Brugia malayi	Patched family protein	0.003	0.0011	0.0074
Brugia malayi	Trypsin family protein	0.0104	0.0235	0.1618
Brugia malayi	Patched family protein	0.003	0.0011	0.0074
Onchocerca volvulus		0.0035	0.0026	0.018
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0035	0.0026	0.0153
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0096	0.0213	0.0213
Echinococcus granulosus	tissue type plasminogen activator	0.0359	0.1016	0.4824
Onchocerca volvulus		0.0359	0.1016	0.6995
Brugia malayi	hypothetical protein	0.0104	0.0235	0.1618
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0035	0.0026	0.0546
Onchocerca volvulus		0.0126	0.0303	0.2084
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0307	0.2117
Mycobacterium ulcerans	hypothetical protein	0.0104	0.0235	0.8196
Echinococcus multilocularis	transmembrane protease serine 3	0.0104	0.0235	0.0235
Brugia malayi	PAN domain containing protein	0.0126	0.0303	0.2084
Onchocerca volvulus		0.0126	0.0303	0.2084
Schistosoma mansoni	cercarial elastase (S01 family)	0.0104	0.0235	0.1595
Brugia malayi	hypothetical protein	0.003	0.0011	0.0074
Brugia malayi	latrophilin 2 splice variant baaae	0.0137	0.0337	0.2318
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0028	0.0028
Trypanosoma brucei	PAB1-binding protein , putative	0.0051	0.0074	0.7568
Trichomonas vaginalis	antibiotic synthetase, putative	0.0035	0.0026	0.0079
Brugia malayi	Trypsin family protein	0.0501	0.1452	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0035	0.0026	0.0903
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.009	0.0193	1
Onchocerca volvulus	Protein patched homolog	0.003	0.0011	0.0074
Brugia malayi	AMP-binding enzyme family protein	0.0035	0.0026	0.018
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0085	0.0178	0.6071
Schistosoma mansoni	cellular tumor antigen P53	0.0101	0.0226	0.1534
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0303	0.2084
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.0115	0.0115
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Brugia malayi	Patched family protein	0.003	0.0011	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0303	0.2084
Echinococcus multilocularis	GPCR, family 2	0.0063	0.0112	0.0112
Schistosoma mansoni	hypothetical protein	0.0104	0.0235	0.1595
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0028	0.0269
Schistosoma mansoni	hypothetical protein	0.0137	0.0337	0.2286
Loa Loa (eye worm)	CYP4Cod1	0.0027	0	0.0002
Loa Loa (eye worm)	oxidoreductase	0.0035	0.0026	0.018
Onchocerca volvulus		0.0501	0.1452	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.009	0.0193	0.1817
Onchocerca volvulus	Pyruvate kinase homolog	0.0034	0.0022	0.015
Leishmania major	pyruvate kinase	0.0034	0.0022	0.0212
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0359	0.1016	1
Echinococcus multilocularis	glycoprotein Antigen 5	0.0104	0.0235	0.0235
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0063	0.0112	0.0112
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0104	0.0235	0.1618
Schistosoma mansoni	hypothetical protein	0.0359	0.1016	0.6898
Echinococcus granulosus	glycoprotein Antigen 5	0.0104	0.0235	0.1116
Brugia malayi	Protein kinase domain containing protein	0.0359	0.1016	0.6995
Loa Loa (eye worm)	patched family protein	0.003	0.0011	0.0074
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0035	0.0026	0.0546
Brugia malayi	Patched related family protein 4	0.003	0.0011	0.0074
Trypanosoma cruzi	trypanothione reductase, putative	0.0047	0.0063	0.0619
Brugia malayi	Patched family protein	0.003	0.0011	0.0074
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0104	0.0235	0.1595
Brugia malayi	Patched family protein	0.003	0.0011	0.0074
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0035	0.0026	0.0084
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0108	0.0249	0.8643
Entamoeba histolytica	acyl-CoA synthetase, putative	0.012	0.0287	0.183
Loa Loa (eye worm)	TK/ROR protein kinase	0.0359	0.1016	0.6995
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Onchocerca volvulus		0.0104	0.0235	0.1618
Brugia malayi	Patched family protein	0.003	0.0011	0.0074
Schistosoma mansoni	transcription factor LCR-F1	0.0147	0.0367	0.2491
Schistosoma mansoni	hypothetical protein	0.0207	0.0551	0.3743
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0059	0.0098	1
Echinococcus granulosus	pyruvate kinase	0.0034	0.0022	0.0104
Brugia malayi	PAN domain containing protein	0.0126	0.0303	0.2084
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0085	0.0178	0.6071
Schistosoma mansoni	hypothetical protein	0.0207	0.0551	0.3743
Brugia malayi	AMP-binding enzyme family protein	0.012	0.0287	0.1973
Echinococcus granulosus	tar DNA binding protein	0.0064	0.0115	0.0547
Onchocerca volvulus		0.0101	0.0226	0.1556
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0047	0.0063	0.1889
Toxoplasma gondii	PAN domain-containing protein	0.105	0.3132	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0085	0.0178	0.6071
Trypanosoma brucei	pyruvate kinase 1, putative	0.0034	0.0022	0.2212
Brugia malayi	hypothetical protein	0.003	0.0011	0.0074
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0063	0.0112	0.0112
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0035	0.0026	0.0546
Plasmodium vivax	glutathione reductase, putative	0.0047	0.0063	0.0521
Loa Loa (eye worm)	PAN domain-containing protein	0.0126	0.0303	0.2084
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.012	0.0287	1
Loa Loa (eye worm)	hypothetical protein	0.05	0.1449	0.9976
Onchocerca volvulus		0.003	0.0011	0.0074
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0034	0.0022	0.0209
Onchocerca volvulus		0.003	0.0011	0.0074
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0035	0.0026	0.0903
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.012	0.0287	1
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0035	0.0026	0.0903
Brugia malayi	Calcitonin receptor-like protein seb-1	0.02	0.053	0.3652
Loa Loa (eye worm)	hypothetical protein	0.024	0.0654	0.4505
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0213	0.1467
Toxoplasma gondii	thioredoxin reductase	0.0047	0.0063	0.0202
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Schistosoma mansoni	cercarial elastase (S01 family)	0.0104	0.0235	0.1595
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0096	0.0213	0.1012
Brugia malayi	Cytochrome P450 family protein	0.0057	0.0092	0.0633
Echinococcus granulosus	expressed conserved protein	0.047	0.1356	0.6439
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0035	0.0026	0.0124
Mycobacterium ulcerans	acyl-CoA synthetase	0.0035	0.0026	0.0903
Echinococcus granulosus	GPCR family 2	0.0063	0.0112	0.053
Leishmania major	4-coumarate:coa ligase-like protein	0.012	0.0287	0.2819
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0235	0.1618
Toxoplasma gondii	kringle domain-containing protein	0.0359	0.1016	0.3243
Loa Loa (eye worm)	PAN domain-containing protein	0.0126	0.0303	0.2084
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0104	0.0235	0.1595
Onchocerca volvulus		0.0126	0.0303	0.2084
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0303	0.2084
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0096	0.0213	0.1447
Leishmania major	4-coumarate:coa ligase-like protein	0.012	0.0287	0.2819
Brugia malayi	Trypsin-like protease protein 5	0.0104	0.0235	0.1618
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0063	0.0112	0.053
Echinococcus multilocularis	tumor protein p63	0.0687	0.2022	0.2022
Entamoeba histolytica	acyl-coA synthetase, putative	0.012	0.0287	0.183
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0235	0.1618
Mycobacterium ulcerans	hypothetical protein	0.012	0.0287	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0035	0.0026	0.0903
Loa Loa (eye worm)	patched family protein	0.003	0.0011	0.0074
Toxoplasma gondii	hypothetical protein	0.0126	0.0303	0.0966
Schistosoma mansoni	cercarial elastase (S01 family)	0.0104	0.0235	0.1595
Schistosoma mansoni	cercarial elastase (S01 family)	0.0104	0.0235	0.1595
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.012	0.0287	1
Echinococcus granulosus	Protein patched homolog 1	0.0215	0.0575	0.273
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0074	0.0628
Brugia malayi	Trypsin family protein	0.0104	0.0235	0.1618
Onchocerca volvulus		0.0126	0.0303	0.2084
Schistosoma mansoni	hypothetical protein	0.0063	0.0112	0.0759
Schistosoma mansoni	hypothetical protein	0.0147	0.0367	0.2491
Onchocerca volvulus		0.003	0.0011	0.0074
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0059	0.0098	0.0957
Leishmania major	acetyl-CoA synthetase, putative	0.0035	0.0026	0.0255
Brugia malayi	Patched family protein	0.003	0.0011	0.0074
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0303	0.2084
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0115	0.0782
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.0115	0.0793
Echinococcus granulosus	pyruvate kinase	0.0034	0.0022	0.0104
Loa Loa (eye worm)	cytochrome P450 family protein	0.0027	0	0.0002
Brugia malayi	Kringle domain containing protein	0.0359	0.1016	0.6995
Leishmania major	4-coumarate:coa ligase-like protein	0.012	0.0287	0.2819
Brugia malayi	CHE-14 protein	0.0215	0.0575	0.3959
Schistosoma mansoni	hypothetical protein	0.0063	0.0112	0.0759
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0508	0.1472	1
Toxoplasma gondii	patched family protein	0.003	0.0011	0.0034
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0115	0.0782
Loa Loa (eye worm)	hypothetical protein	0.012	0.0287	0.1973
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.02	0.053	0.3652
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Leishmania major	acetyl-CoA synthetase, putative	0.0035	0.0026	0.0255
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Schistosoma mansoni	pyruvate kinase	0.0034	0.0022	0.0148
Trypanosoma brucei	pyruvate kinase 1	0.0034	0.0022	0.2212
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0115	0.0782
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0035	0.0026	0.0903
Echinococcus multilocularis	Niemann Pick C1 protein	0.0714	0.2105	0.2105
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0034	0.0022	0.0212
Brugia malayi	Cytochrome P450 family protein	0.0027	0	0.0002
Schistosoma mansoni	cercarial elastase (S01 family)	0.0104	0.0235	0.1595
Loa Loa (eye worm)	hypothetical protein	0.003	0.0011	0.0074
Mycobacterium tuberculosis	Probable oxidoreductase	0.012	0.0286	0.9985
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0035	0.0026	0.0546
Brugia malayi	abnormal cell lineage protein 10 (Protein lin-10), putative	0.0062	0.0107	0.0734
Mycobacterium ulcerans	acyl-CoA synthetase	0.0035	0.0026	0.0903
Echinococcus multilocularis	fibrillin 1	0.0027	0.0000082373	0.0000082373
Brugia malayi	Patched family protein	0.003	0.0011	0.0074
Entamoeba histolytica	hypothetical protein	0.0147	0.0367	0.2395
Toxoplasma gondii	patched family protein	0.003	0.0011	0.0034
Trypanosoma brucei	trypanothione reductase	0.0047	0.0063	0.6468
Loa Loa (eye worm)	hypothetical protein	0.0263	0.0723	0.4976
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0108	0.0249	0.8643
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0096	0.0213	0.1447
Schistosoma mansoni	cercarial elastase (S01 family)	0.0104	0.0235	0.1595
Echinococcus granulosus	amyloid beta A4 protein	0.0069	0.0129	0.0612

Activities

Activity type	Activity value	Assay description	Source	Reference
Kd (binding)	= 0.59 uM	Binding affinity of compound to P-glycoprotein recombinant domain of prenylated xanthones was evaluated	ChEMBL.	10890160

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

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Detailed information for compound 34875