Detailed information for compound 368791

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 352.453 | Formula: C19H20N4OS
  • H donors: 2 H acceptors: 3 LogP: 3.83 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNc1nccc(n1)c1ccc(s1)C(=O)NCCc1ccc(cc1)C
  • InChi: 1S/C19H20N4OS/c1-13-3-5-14(6-4-13)9-11-21-18(24)17-8-7-16(25-17)15-10-12-22-19(20-2)23-15/h3-8,10,12H,9,11H2,1-2H3,(H,21,24)(H,20,22,23)
  • InChiKey: KWWNNIKIVXQIJU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0032 0.0118
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0032 0.0343
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0011 0.001
Onchocerca volvulus 0.0037 0.0077 0.0076
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0011 0.0115
Echinococcus multilocularis serine:threonine protein kinase N2 0.0013 0.0018 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0039
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0031 0.0331
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0031 0.039
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0048 0.0176
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0048 0.051
Echinococcus granulosus Protein kinase C brain isozyme 0.0013 0.0018 0.0195
Echinococcus granulosus DNA methyltransferase 2, putative 0.0019 0.0033 0.0354
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0031 0.0114
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0006 0.0066
Brugia malayi steroid hormone receptor 0.001 0.0011 0.0015
Schistosoma mansoni serine/threonine-protein kinase 0.0028 0.0053 0.0568
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.032 0.1177
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0019 0.0033 0.0122
Entamoeba histolytica protein kinase, putative 0.0013 0.0018 0.0229
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0011 0.0015
Schistosoma mansoni serine/threonine-protein kinase 0.0028 0.0053 0.0568
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0039
Trypanosoma brucei DNA damage repair protein, putative 0.0006 0.0001 0.0005
Toxoplasma gondii hypothetical protein 0.0047 0.0101 0.037
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0337 0.0797 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.0358 1
Echinococcus multilocularis global transcription activator snf2l2 0.0065 0.0144 0.1529
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0039
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0031 0.0114
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0154
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0006 0.0089
Brugia malayi Importin beta-1 subunit 0.0028 0.0054 0.0075
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0011 0.0115
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0048 0.0176
Echinococcus granulosus serine:threonine protein kinase N2 0.0013 0.0018 0.0195
Leishmania major DNA damage repair protein, putative 0.0006 0.0001 0.0005
Trichomonas vaginalis AGC family protein kinase 0.004 0.0084 0.1341
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0031 0.0498
Schistosoma mansoni thyroid hormone receptor 0.001 0.0011 0.0115
Entamoeba histolytica hypothetical protein 0.0035 0.0071 0.0892
Trichomonas vaginalis AGC family protein kinase 0.0015 0.0024 0.0388
Loa Loa (eye worm) AGC/NDR protein kinase 0.0013 0.0018 0.026
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0024 0.0256
Loa Loa (eye worm) BRM protein 0.0042 0.0087 0.1238
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0154
Echinococcus multilocularis geminin 0.0164 0.0382 0.4064
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0019 0.0033 0.0418
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0012 0.0016 0.0058
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0013 0.0018 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0011 0.0154
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.026
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0031 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0032 0.0114
Brugia malayi Disco-interacting protein 2 homolog 0.0037 0.0077 0.0106
Brugia malayi Muscleblind-like protein 0.0145 0.0335 0.0461
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0118
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0018 0.0293
Echinococcus granulosus global transcription activator snf2l2 0.0065 0.0144 0.1529
Echinococcus granulosus muscleblind protein 0.0145 0.0335 0.3566
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0265 0.3768
Entamoeba histolytica hypothetical protein 0.0035 0.0071 0.0892
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0086 0.0317
Loa Loa (eye worm) AGC/AKT protein kinase 0.004 0.0084 0.1188
Entamoeba histolytica hypothetical protein 0.0035 0.0071 0.0892
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0118
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0129 0.1374
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0018 0.0293
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.0691 0.2534
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0019 0.0033 0.0122
Giardia lamblia Kinase, AGC PKA 0.0025 0.0047 0.017
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0048 0.0602
Schistosoma mansoni Smad4 0.0008 0.0006 0.0066
Echinococcus granulosus Glutaredoxin protein 5 0.0025 0.0047 0.0497
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0011 0.0154
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0006 0.0001 0.0002
Schistosoma mansoni DNA polymerase eta 0.0019 0.0032 0.0343
Loa Loa (eye worm) glutaminase 2 0.0265 0.0624 0.886
Echinococcus multilocularis BRK domain containing protein 0.0011 0.0014 0.0153
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0031 0.0479
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0011 0.0115
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0004 0.0042
Echinococcus granulosus cpg binding protein 0.0062 0.0136 0.1447
Trichomonas vaginalis AGC family protein kinase 0.004 0.0084 0.1341
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0011 0.0154
Leishmania major telomerase reverse transcriptase, putative 0.1139 0.2722 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0018 0.0067
Trypanosoma brucei rac serine-threonine kinase, putative 0.004 0.0084 0.0307
Brugia malayi Telomerase reverse transcriptase 0.303 0.7265 1
Entamoeba histolytica protein kinase, putative 0.004 0.0084 0.105
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0031 0.0498
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0458
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0039
Echinococcus granulosus dna polymerase kappa 0.0019 0.0032 0.0343
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0004 0.0042
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0024 0.0256
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0039
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.001 0.0012 0.0043
Echinococcus multilocularis dna polymerase eta 0.0019 0.0032 0.0343
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0025 0.0047 0.0497
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0024 0.0342
Schistosoma mansoni serine/threonine kinase 0.0013 0.0018 0.0195
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0008 0.0085
Echinococcus granulosus protein kinase c iota type 0.0013 0.0018 0.0195
Schistosoma mansoni smad1 5 8 and 0.0008 0.0006 0.0066
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0025 0.0047 0.0504
Entamoeba histolytica protein kinase 2, putative 0.0025 0.0047 0.0595
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0013 0.0018 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0039
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0025 0.0047 0.0497
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0011 0.0154
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0032 0.0118
Brugia malayi nuclear receptor NHR-88 0.001 0.0011 0.0015
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0025 0.0047 0.0504
Brugia malayi CXXC zinc finger family protein 0.006 0.0132 0.0182
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.0704 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0042 0.0669
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0024 0.0089
Leishmania major importin beta-1 subunit, putative 0.0023 0.0042 0.0153
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0013 0.0018 0.0195
Loa Loa (eye worm) hypothetical protein 0.0028 0.0054 0.0773
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0039
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0071 0.0756
Loa Loa (eye worm) hypothetical protein 0.0006 0.0002 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0118
Loa Loa (eye worm) hypothetical protein 0.0037 0.0077 0.1094
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0013 0.0018 0.026
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0154
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0019 0.0033 0.0354
Schistosoma mansoni cpg binding protein 0.006 0.0132 0.1407
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0024 0.0033
Brugia malayi polk-prov protein 0.0006 0.0001 0.0002
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0096 0.0218 0.2731
Trichomonas vaginalis AGC family protein kinase 0.004 0.0084 0.1341
Schistosoma mansoni smad1 5 8 and 0.0008 0.0006 0.0066
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0013 0.0018 0.0195
Giardia lamblia Telomerase catalytic subunit 0.1139 0.2722 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.0001 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0018 0.0067
Loa Loa (eye worm) hypothetical protein 0.0145 0.0335 0.476
Loa Loa (eye worm) hypothetical protein 0.0145 0.0335 0.476
Brugia malayi polybromodomain protein 0.0006 0.0002 0.0002
Echinococcus multilocularis serine:threonine protein kinase N2 0.0013 0.0018 0.0195
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.0691 0.2538
Brugia malayi Protein kinase domain containing protein 0.004 0.0084 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0118
Schistosoma mansoni hypothetical protein 0.0397 0.094 1
Echinococcus granulosus disco interacting protein 2 0.0037 0.0077 0.0819
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0032 0.0343
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0082 0.0184 0.0677
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0013 0.0018 0.0195
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0118
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.0021
Trichomonas vaginalis AGC family protein kinase 0.004 0.0084 0.1341
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0118
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0013 0.0018 0.026
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0011 0.0015
Loa Loa (eye worm) AGC/PKN protein kinase 0.0013 0.0018 0.026
Echinococcus multilocularis nervana 2 0.0025 0.0047 0.0497
Echinococcus granulosus serine/threonine protein kinase 0.0028 0.0053 0.0568
Leishmania major DNA polymerase eta, putative 0.0006 0.0001 0.0005
Plasmodium vivax DEAD/DEAH helicase, putative 0.001 0.0012 0.0043
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0024 0.0089
Echinococcus granulosus protein kinase C gamma type 0.0013 0.0018 0.0195
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0032 0.0517
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0028 0.0053 0.0192
Plasmodium falciparum DEAD/DEAH box helicase, putative 0.001 0.0012 0.0043
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0011 0.0115
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0086 0.0312
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0031 0.0114
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0031 0.0442
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0032 0.0517
Trypanosoma brucei hypothetical protein, conserved 0.0006 0.0001 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0011 0.0015
Toxoplasma gondii hypothetical protein 0.0082 0.0184 0.0677
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0024 0.0089
Trichomonas vaginalis AGC family protein kinase 0.004 0.0084 0.1341
Trichomonas vaginalis AGC family protein kinase 0.004 0.0084 0.1341
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0008 0.0113
Toxoplasma gondii exonuclease III APE 0.0018 0.0031 0.0114
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0032 0.0118
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0006 0.0066
Echinococcus multilocularis snurportin 1 0.0299 0.0704 0.7492
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0032 0.0118
Schistosoma mansoni atypical protein kinase C 0.0013 0.0018 0.0195
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0118 0.0434
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0048 0.0176
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0018 0.0195
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0024 0.0089
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0011 0.0015
Loa Loa (eye worm) BRM protein 0.0034 0.0068 0.0968
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0011 0.0015
Entamoeba histolytica protein kinase, putative 0.004 0.0084 0.105
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0006 0.0001 0.0005
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0014 0.002
Plasmodium falciparum DNA repair protein REV1, putative 0.0006 0.0001 0.0005
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0154
Trypanosoma brucei unspecified product 0.0013 0.0018 0.0067
Toxoplasma gondii RNA-directed DNA polymerase 0.1139 0.2722 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0039
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0011 0.0115
Brugia malayi BRM protein 0.0065 0.0144 0.0198
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0011 0.0115
Entamoeba histolytica hypothetical protein 0.0035 0.0071 0.0892
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.0018
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0011 0.0115
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0031 0.011
Schistosoma mansoni smad1 5 8 and 0.0008 0.0006 0.0066
Echinococcus granulosus nervana 2 0.0025 0.0047 0.0497
Schistosoma mansoni hypothetical protein 0.0164 0.0382 0.4064
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1139 0.2722 1
Echinococcus granulosus dna polymerase eta 0.0019 0.0032 0.0343
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0031 0.0114
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0048 0.0172
Schistosoma mansoni cpg binding protein 0.0062 0.0136 0.1447
Echinococcus multilocularis nervana 2 0.0025 0.0047 0.0497
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.0691 0.2538
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0025 0.0047 0.017
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0024 0.0084
Echinococcus granulosus FTZ F1 alpha 0.001 0.0011 0.0115
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0132 0.1878
Plasmodium vivax importin-beta 2, putative 0.0028 0.0054 0.02
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0018 0.0195
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0011 0.0115
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0031 0.021
Brugia malayi nuclear hormone receptor 0.001 0.0011 0.0015
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0024 0.0256
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0118
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0032 0.0343
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0011 0.001
Giardia lamblia DINP protein human, muc B family 0.0019 0.0032 0.0114
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.094 1
Schistosoma mansoni ap endonuclease 0.0018 0.0031 0.0331
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0024 0.0256
Echinococcus multilocularis cpg binding protein 0.0062 0.0136 0.1447
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0011 0.0115
Onchocerca volvulus 0.001 0.0011 0.001
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0013 0.0018 0.0195
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0018 0.0195
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0032 0.0498
Trypanosoma brucei telomerase reverse transcriptase 0.1139 0.2722 1
Plasmodium falciparum flap endonuclease 1 0.0025 0.0048 0.0176
Echinococcus granulosus Smad4 0.0008 0.0006 0.0066
Schistosoma mansoni hypothetical protein 0.0035 0.0071 0.0756
Echinococcus granulosus Chromo domain 0.0011 0.0014 0.0153
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0118
Plasmodium vivax helicase, putative 0.0006 0.0001 0.0003
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0002 0.0039
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0032 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0011 0.0015
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0032 0.0405
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0024 0.0256
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0011 0.0015
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0154
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0032 0.0114
Schistosoma mansoni hypothetical protein 0.0299 0.0704 0.7492
Schistosoma mansoni helicase 0.0065 0.0144 0.1529
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0054 0.0579
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0031 0.0331
Echinococcus granulosus BRK domain containing protein 0.0011 0.0014 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0011 0.0154
Echinococcus granulosus helicase 0.0006 0.0001 0.001
Echinococcus multilocularis Smad4 0.0008 0.0006 0.0066
Schistosoma mansoni cpg binding protein 0.0062 0.0136 0.1447
Brugia malayi Protein kinase domain containing protein 0.0013 0.0018 0.0025
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0032 0.0498
Schistosoma mansoni ap endonuclease 0.0018 0.0031 0.0331
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0086 0.0312
Echinococcus granulosus geminin 0.0164 0.0382 0.4064
Schistosoma mansoni helicase 0.0006 0.0001 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0001 0.0005
Brugia malayi protein kinase C II. 0.0013 0.0018 0.0025
Echinococcus multilocularis disco interacting protein 2 0.0037 0.0077 0.0819
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0011 0.0115
Brugia malayi isocitrate dehydrogenase 0.0015 0.0024 0.0033
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0008 0.0085
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0011 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0018 0.0067
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0006 0.0066
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0011 0.0154
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0024 0.0089
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0154
Schistosoma mansoni hypothetical protein 0.0164 0.0382 0.4064
Brugia malayi glutaminase DH11.1 0.0265 0.0624 0.0859
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0048 0.0176
Brugia malayi SNF2 family N-terminal domain containing protein 0.0006 0.0001 0.0001
Plasmodium vivax DNA repair protein REV1, putative 0.0006 0.0001 0.0005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0011 0.0115
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0011 0.0014 0.0153
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0032 0.0244
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0011 0.0115
Brugia malayi ecdysteroid receptor 0.001 0.0011 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0001 0.0005
Trichomonas vaginalis lymphoid specific helicase, putative 0.0012 0.0016 0.0253
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0039
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0004 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0011 0.0015
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0071 0.0756
Entamoeba histolytica hypothetical protein 0.0023 0.0042 0.0524
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0039
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0025 0.0047 0.0174
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0118
Echinococcus multilocularis BRK domain containing protein 0.0011 0.0014 0.0153
Echinococcus multilocularis Chromo domain 0.0011 0.0014 0.0153
Trypanosoma cruzi Protein kinase B 0.0028 0.0053 0.0192
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0042 0.0669
Toxoplasma gondii AGC kinase 0.0038 0.0078 0.0286
Plasmodium vivax hypothetical protein, conserved 0.0006 0.0001 0.0003
Leishmania major DNA polymerase eta, putative 0.0019 0.0032 0.0118
Schistosoma mansoni helicase 0.0006 0.0001 0.001
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0032 0.0343
Onchocerca volvulus 0.006 0.0132 0.0131
Brugia malayi MH2 domain containing protein 0.0116 0.0265 0.0365
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0037 0.0077 0.0819
Brugia malayi Hr1 repeat family protein 0.0013 0.0018 0.0025
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0011 0.0115
Echinococcus multilocularis BRK domain containing protein 0.0011 0.0014 0.0153
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0002 0.0039
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0032 0.0343
Schistosoma mansoni hypothetical protein 0.0013 0.0018 0.0193
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0335 0.3566
Schistosoma mansoni coup transcription factor 0.001 0.0011 0.0115
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0032 0.0244
Loa Loa (eye worm) SNF2 family domain-containing protein 0.0006 0.0001 0.0013
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0042 0.0149
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0038 0.0078 0.1104
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0039
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0024 0.0089
Echinococcus multilocularis protein kinase c iota type 0.0013 0.0018 0.0195
Echinococcus granulosus Helicase SANT associated DNA binding 0.0006 0.0001 0.001
Echinococcus granulosus importin subunit beta 1 0.0028 0.0054 0.0579
Trypanosoma brucei DNA damage repair protein, putative 0.0006 0.0001 0.0005
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0032 0.0118
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.0001 0.0005
Mycobacterium ulcerans glutaminase 0.0265 0.0624 1
Trypanosoma brucei unspecified product 0.0013 0.0018 0.0067
Leishmania major DNA polymerase kappa, putative 0.0019 0.0032 0.0118
Brugia malayi Flap endonuclease-1 0.0025 0.0048 0.0066
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0031 0.0043
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0031 0.5
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0011 0.001
Trypanosoma brucei chrX additional, unordered contigs 0.0006 0.0001 0.0005
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0054 0.02
Echinococcus granulosus snurportin 1 0.0299 0.0704 0.7492
Plasmodium falciparum Snf2-related CBP activator, putative 0.0006 0.0001 0.0003
Echinococcus multilocularis BRK domain containing protein 0.0011 0.0014 0.0153
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0054 0.02
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0011 0.0154
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.0691 0.2534
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0013 0.0018 0.026
Schistosoma mansoni importin beta-1 0.0028 0.0054 0.0579
Leishmania major modification methylase-like protein 0.0019 0.0033 0.0122
Echinococcus multilocularis muscleblind protein 0.0145 0.0335 0.3566
Brugia malayi hypothetical protein 0.0035 0.0071 0.0098
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0018 0.0195
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0265 0.3768
Schistosoma mansoni glutaminase 0.0265 0.0624 0.6638
Plasmodium vivax telomerase reverse transcriptase, putative 0.1139 0.2722 1
Echinococcus multilocularis BRK domain 0.0011 0.0014 0.0153
Loa Loa (eye worm) Smad1 0.0008 0.0006 0.0089
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0006 0.0089
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0048 0.0172
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1139 0.2722 1
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0018 0.0195
Trypanosoma brucei hypothetical protein, conserved 0.0006 0.0001 0.0005
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0031 0.011
Schistosoma mansoni hypothetical protein 0.0006 0.0001 0.001
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0048 0.0768
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0154
Echinococcus multilocularis serine:threonine protein kinase 38 0.0013 0.0018 0.0195
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0008 0.0011
Echinococcus granulosus NDR protein kinase 0.0013 0.0018 0.0195
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0011 0.0115
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0011 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0011 0.0015
Trichomonas vaginalis glutaminase, putative 0.0265 0.0624 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0011 0.0115
Brugia malayi RNA, U transporter 1 0.008 0.0178 0.0245
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0054 0.02
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.032 0.1172
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0024 0.0256
Loa Loa (eye worm) glutaminase 0.0265 0.0624 0.886
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0013 0.0018 0.0282
Echinococcus granulosus nervana 2 0.0025 0.0047 0.0497
Brugia malayi MH1 domain containing protein 0.0008 0.0006 0.0009
Echinococcus multilocularis Helicase SANT associated, DNA binding 0.0006 0.0001 0.001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0011 0.0015
Echinococcus granulosus dnaJ subfamily B 0.0397 0.094 1
Entamoeba histolytica protein kinase, putative 0.0038 0.0078 0.0975
Brugia malayi MH2 domain containing protein 0.0008 0.0006 0.0009
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0108 0.0392
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0118
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0011 0.0015
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0011 0.0115
Brugia malayi MH2 domain containing protein 0.0008 0.0006 0.0009
Brugia malayi p70 ribosomal S6 kinase beta 0.0038 0.0078 0.0107
Schistosoma mansoni thyroid hormone receptor 0.001 0.0011 0.0115
Echinococcus granulosus serine threonine protein kinase nrc 0.0025 0.0047 0.0504
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0011 0.0015
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0025 0.0047 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0011 0.0015
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0011 0.0115
Echinococcus multilocularis helicase 0.0006 0.0001 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0032 0.0114
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0019 0.0033 0.0122
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0013 0.0018 0.0195
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0004 0.0042
Toxoplasma gondii DNA methyltransferase 2, putative 0.0019 0.0033 0.0122
Echinococcus multilocularis smad 0.0008 0.0006 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0011 0.0015
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0032 0.0458
Echinococcus multilocularis rac serine:threonine kinase 0.0028 0.0053 0.0568
Schistosoma mansoni hypothetical protein 0.0011 0.0014 0.0153
Echinococcus multilocularis protein kinase c epsilon type 0.0013 0.0018 0.0195
Schistosoma mansoni flap endonuclease-1 0.0023 0.0042 0.0448
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0019 0.0033 0.0354
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0031 0.011
Echinococcus granulosus flap endonuclease 1 0.0025 0.0048 0.051
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0039
Plasmodium falciparum importin beta, putative 0.0028 0.0054 0.02
Trichomonas vaginalis AGC family protein kinase 0.004 0.0084 0.1341
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0011 0.0115
Giardia lamblia DNA repair protein RAD52 0.0337 0.0797 0.2925
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0048 0.0681
Echinococcus multilocularis BRK domain containing protein 0.0011 0.0014 0.0153
Trichomonas vaginalis helicase, putative 0.0006 0.0002 0.0039
Trypanosoma brucei unspecified product 0.0019 0.0032 0.0118
Echinococcus multilocularis polybromo 1 0.0006 0.0002 0.0019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0011 0.0115
Brugia malayi SET domain containing protein 0.0007 0.0003 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0039
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0032 0.0114
Echinococcus granulosus polybromo 1 0.0006 0.0002 0.0019
Echinococcus multilocularis serine threonine protein kinase 0.0013 0.0018 0.0195
Leishmania major DNA polymerase kappa, putative 0.0006 0.0001 0.0005
Entamoeba histolytica hypothetical protein 0.0096 0.0218 0.2731
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0018 0.0293
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0018 0.0195
Echinococcus granulosus protein kinase c epsilon type 0.0013 0.0018 0.0195
Schistosoma mansoni smad 0.0008 0.0006 0.0066
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0024 0.0256
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.032 0.1177
Echinococcus multilocularis Glutaredoxin protein 5 0.0025 0.0047 0.0497
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0011 0.0115
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0013 0.0018 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0011 0.0015
Entamoeba histolytica PH domain containing protein kinase, putative 0.0028 0.0053 0.0669
Brugia malayi MH1 domain containing protein 0.0008 0.0006 0.0009
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0086 0.0312
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0006 0.0066
Entamoeba histolytica PH domain containing protein kinase, putative 0.0028 0.0053 0.0669
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0032 0.0114
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0001 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0011 0.0015
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0024 0.0084
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0019 0.0033 0.0122
Echinococcus granulosus smad 0.0008 0.0006 0.0066
Loa Loa (eye worm) helicase DNA-binding protein 0.0011 0.0014 0.0204
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0018 0.0195
Brugia malayi Protein kinase domain containing protein 0.0013 0.0018 0.0025
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0032 0.0044
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0011 0.0115
Schistosoma mansoni polybromo-1 0.0006 0.0002 0.0019
Mycobacterium ulcerans hypothetical protein 0.0154 0.0358 0.5726
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0024 0.0089
Echinococcus multilocularis BRK domain containing protein 0.0011 0.0014 0.0153
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0071 0.0756
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0011 0.0115
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0011 0.0115
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0006 0.0066
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0004 0.0042
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0042 0.0669
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0011 0.0154
Brugia malayi Smad1 0.0008 0.0006 0.0009
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0011 0.0115
Schistosoma mansoni nuclear hormone receptor 0.001 0.0011 0.0115
Plasmodium falciparum telomerase reverse transcriptase 0.1139 0.2722 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 25000 nM Inhibition of AKT3 in presence of 0.2 uM ATP ChEMBL. 16765046
IC50 (binding) > 25000 nM Inhibition of AKT3 in presence of 0.2 uM ATP ChEMBL. 16765046

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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