Detailed information for compound 373999

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 251.217 | Formula: C10H10FN5O2
  • H donors: 3 H acceptors: 5 LogP: -0.91 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@@H]1[C@H](/C/1=C\n1cnc2c1c(O)nc(n2)N)F
  • InChi: 1S/C10H10FN5O2/c11-6-4(5(6)2-17)1-16-3-13-8-7(16)9(18)15-10(12)14-8/h1,3,5-6,17H,2H2,(H3,12,14,15,18)/b4-1-/t5-,6-/m0/s1
  • InChiKey: QPHJZEBBTPCAJK-CQHDBRBHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0239 0.4351 0.8746
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0421 0.0399
Schistosoma mansoni hypothetical protein 0.0055 0.0819 0.1042
Trypanosoma brucei carbonic anhydrase-like protein 0.0252 0.4601 0.4552
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.006 0.0916 0.0835
Trichomonas vaginalis thymidine kinase, putative 0.0533 1 1
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0047 0.0667 0.2035
Giardia lamblia Ribonuclease H 0.0023 0.0191 0.0047
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0427 0.1171
Schistosoma mansoni rab6-interacting 0.0064 0.0984 0.1277
Schistosoma mansoni phosphoglucomutase 0.0023 0.0191 0.0146
Schistosoma mansoni lipoxygenase 0.0382 0.7096 1
Loa Loa (eye worm) hypothetical protein 0.0161 0.2853 0.5672
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.006 0.0916 0.0835
Loa Loa (eye worm) hypothetical protein 0.0051 0.0729 0.1313
Leishmania major thymidine kinase, putative 0.0533 1 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0105 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0342 0.0321
Schistosoma mansoni carbonic anhydrase-related 0.0161 0.2853 0.3945
Giardia lamblia GTOR 0.0051 0.0746 0.061
Echinococcus multilocularis glycogen phosphorylase 0.0109 0.1861 0.253
Echinococcus granulosus thymidylate kinase 0.0154 0.2711 0.3742
Trypanosoma brucei thymidylate kinase, putative 0.0154 0.2711 0.2646
Schistosoma mansoni thymidylate kinase 0.0154 0.2711 0.3742
Echinococcus granulosus survival motor neuron protein 1 0.0271 0.4962 0.6955
Echinococcus granulosus carbonic anhydrase II 0.0252 0.4601 0.6439
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0548 0.0655
Echinococcus multilocularis carbonic anhydrase 0.0161 0.2853 0.3945
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0154 0.2711 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0064 0.0984 0.3373
Schistosoma mansoni survival motor neuron protein 0.0055 0.0819 0.1042
Onchocerca volvulus 0.0055 0.0819 0.131
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0549 0.0657
Onchocerca volvulus 0.003 0.0336 0.0303
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0252 0.4601 0.9258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0493 0.0471
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0291 0.0269
Toxoplasma gondii thymidylate kinase 0.0154 0.2711 0.9482
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0291 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0348 0.0326
Toxoplasma gondii target of rapamycin (TOR), putative 0.0038 0.0493 0.1412
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0981 0.09
Schistosoma mansoni ap endonuclease 0.002 0.0145 0.008
Echinococcus granulosus carbonic anhydrase 0.0161 0.2853 0.3945
Echinococcus multilocularis geminin 0.0376 0.698 0.9834
Entamoeba histolytica hypothetical protein 0.0041 0.0549 0.041
Brugia malayi Doublecortin family protein 0.0064 0.0984 0.1983
Echinococcus multilocularis lipoxygenase domain containing protein 0.0064 0.0984 0.1277
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0051 0.0746 0.1504
Schistosoma mansoni carbonic anhydrase 0.0161 0.2853 0.3945
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0746 0.0725
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0252 0.4601 0.4552
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0427 0.0482
Trypanosoma cruzi thymidylate kinase, putative 0.0154 0.2711 0.2646
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.1104 0.1449
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0089 0.0066
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0051 0.0746 0.0663
Schistosoma mansoni hypothetical protein 0.0024 0.0211 0.0175
Echinococcus multilocularis Glycosyl transferase, family 35 0.0109 0.1861 0.253
Schistosoma mansoni hypothetical protein 0.0059 0.0895 0.1151
Brugia malayi RNase H family protein 0.0023 0.0191 0.0384
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0051 0.0746 0.0663
Plasmodium falciparum thymidylate kinase 0.0154 0.2711 0.9482
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0746 0.0725
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0054 0.0802 0.1018
Loa Loa (eye worm) hypothetical protein 0.0161 0.2853 0.5672
Entamoeba histolytica hypothetical protein 0.0041 0.0549 0.041
Brugia malayi Bromodomain containing protein 0.0044 0.06 0.1209
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0145 0.0056
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.093 0.3003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0746 0.0725
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0427 0.0482
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0145 0.0056
Schistosoma mansoni phosphoglucomutase 0.0023 0.0191 0.0146
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0105 0.0023
Giardia lamblia Thymidine kinase 0.0533 1 1
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0154 0.2711 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0089 0.0066
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0981 0.1273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0493 0.0471
Trypanosoma cruzi thymidylate kinase, putative 0.0154 0.2711 0.2646
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0211 0.0251
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0161 0.2853 0.575
Loa Loa (eye worm) hypothetical protein 0.0047 0.0654 0.1159
Trichomonas vaginalis thymidylate kinase, putative 0.0154 0.2711 0.2695
Trichomonas vaginalis glycogen phosphorylase, putative 0.0109 0.1861 0.1843
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0291 0.0269
Plasmodium vivax thymidylate kinase, putative 0.0154 0.2711 1
Echinococcus granulosus geminin 0.0376 0.698 0.9834
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0089 0.0066
Brugia malayi Pre-SET motif family protein 0.0035 0.0427 0.086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.029 0.0269
Brugia malayi RNase H family protein 0.0023 0.0191 0.0384
Echinococcus granulosus Glycosyl transferase family 35 0.0109 0.1861 0.253
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0105 0.0016
Brugia malayi RNase H family protein 0.0023 0.0191 0.0384
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0252 0.4601 0.9271
Schistosoma mansoni thymidylate kinase 0.0154 0.2711 0.3742
Echinococcus granulosus zinc finger protein 0.0024 0.0221 0.0189
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0252 0.4601 0.6439
Loa Loa (eye worm) hypothetical protein 0.0271 0.4962 1
Brugia malayi carbohydrate phosphorylase 0.0109 0.1861 0.3751
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0348 0.0326
Trichomonas vaginalis ribonuclease H1, putative 0.0023 0.0191 0.0169
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0145 0.0291
Loa Loa (eye worm) hypothetical protein 0.0044 0.0602 0.1052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0493 0.0471
Trypanosoma brucei ingi protein (ORF1) 0.0024 0.0228 0.014
Leishmania major carbonic anhydrase-like protein 0.0252 0.4601 0.4552
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0105 0.0023
Giardia lamblia Deoxynucleoside kinase 0.0379 0.7038 0.6995
Echinococcus granulosus histone lysine methyltransferase setb 0.0054 0.0802 0.1018
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0146 0.0117
Toxoplasma gondii hypothetical protein 0.0161 0.2853 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0493 0.0471
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0105 0.0023
Entamoeba histolytica glycogen phosphorylase, putative 0.0047 0.0667 0.053
Schistosoma mansoni glycogen phosphorylase 0.0047 0.0667 0.0825
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0981 0.1273
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0024 0.0228 0.014
Brugia malayi Bromodomain containing protein 0.0088 0.1441 0.2904
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0051 0.0746 0.061
Schistosoma mansoni hypothetical protein 0.0154 0.2711 0.3742
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0051 0.0746 0.0938
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0336 0.0507
Toxoplasma gondii ribonuclease HI protein 0.0023 0.0191 0.0313
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0132 0.0062
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0145 0.0153
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0051 0.0746 0.0663
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0051 0.0746 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.029 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0291 0.0269
Entamoeba histolytica hypothetical protein 0.0041 0.0549 0.041
Trichomonas vaginalis set domain proteins, putative 0.0272 0.4984 0.4973
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0105 0.0023
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0981 0.3259
Toxoplasma gondii exonuclease III APE 0.002 0.0145 0.0145
Echinococcus granulosus ribonuclease H1 0.0023 0.0191 0.0146
Plasmodium falciparum carbonic anhydrase 0.0161 0.2853 1
Trypanosoma brucei ingi protein (ORF1) 0.0024 0.0228 0.014
Plasmodium falciparum LCCL domain-containing protein 0.0064 0.0984 0.3199
Plasmodium vivax SET domain protein, putative 0.0035 0.0427 0.1235
Loa Loa (eye worm) hypothetical protein 0.0054 0.0802 0.1464
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0145 0.0115
Echinococcus multilocularis Polycystic kidney disease protein 0.0064 0.0984 0.1277
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0105 0.0016
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0051 0.0746 0.0663
Loa Loa (eye worm) hypothetical protein 0.0064 0.0984 0.1837
Echinococcus multilocularis lipoxygenase domain containing protein 0.0064 0.0984 0.1277
Trypanosoma brucei thymidine kinase 0.0533 1 1
Echinococcus multilocularis carbonic anhydrase 0.0161 0.2853 0.3945
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0981 0.3188
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0132 0.0062
Schistosoma mansoni glycogen phosphorylase 0.0109 0.1861 0.253
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0802 0.1018
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0268 0.4908 0.9888
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0023 0.0191 0.018
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0427 0.0482
Entamoeba histolytica hypothetical protein 0.0041 0.0549 0.041
Echinococcus granulosus carbonic anhydrase 0.0161 0.2853 0.3945
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0161 0.2853 0.575
Echinococcus granulosus glycogen phosphorylase 0.0109 0.1861 0.253
Trichomonas vaginalis thymidine kinase, putative 0.0533 1 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0105 0.0023
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0549 0.0657
Brugia malayi Pre-SET motif family protein 0.0239 0.4351 0.8768
Entamoeba histolytica glycogen phosphorylase, putative 0.0047 0.0667 0.053
Trypanosoma cruzi ribonuclease H1, putative 0.0023 0.0191 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0544 0.0523
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0493 0.0471
Schistosoma mansoni cpg binding protein 0.0034 0.0411 0.046
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0161 0.2853 0.575
Trypanosoma brucei thymidylate kinase, putative 0.0154 0.2711 0.2646
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.0225 0.0137
Echinococcus multilocularis cpg binding protein 0.0034 0.0411 0.046
Trypanosoma cruzi ISWI complex protein 0.0018 0.0094 0.0005
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0161 0.2853 0.575
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0089 0.0066
Schistosoma mansoni polycystin 1-related 0.0064 0.0984 0.1277
Schistosoma mansoni rab6-interacting 0.0064 0.0984 0.1277
Loa Loa (eye worm) hypothetical protein 0.0064 0.0984 0.1837
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.1104 0.1449
Echinococcus multilocularis zinc finger protein 0.0024 0.0221 0.0189
Schistosoma mansoni carbonic anhydrase-related 0.0161 0.2853 0.3945
Trypanosoma cruzi ribonuclease H1, putative 0.0023 0.0191 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0544 0.0523
Schistosoma mansoni cpg binding protein 0.0034 0.0411 0.046
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0161 0.2853 0.575
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0041 0.0545 0.046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.029 0.0269
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0981 0.1273
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0145 0.0123
Giardia lamblia Glycogen phosphorylase 0.0109 0.1861 0.1742
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0089 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0493 0.0471
Brugia malayi PHD-finger family protein 0.003 0.0338 0.0682
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0348 0.0326
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0252 0.4601 0.9271
Echinococcus multilocularis glycogen phosphorylase 0.0109 0.1861 0.253
Trypanosoma brucei ribonuclease H1 0.0023 0.0191 0.0103
Echinococcus multilocularis carbonic anhydrase II 0.0252 0.4601 0.6439
Entamoeba histolytica Thymidylate kinase, putative 0.0154 0.2711 0.2604
Onchocerca volvulus 0.0272 0.4984 1
Schistosoma mansoni carbonic anhydrase-related 0.0161 0.2853 0.3945
Echinococcus granulosus lipoxygenase domain containing protein 0.0064 0.0984 0.1277
Leishmania major hypothetical protein, conserved 0.006 0.0916 0.0835
Trypanosoma brucei RNA helicase, putative 0.0085 0.1383 0.1306
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0544 0.0523
Loa Loa (eye worm) phosphatidylinositol 3 0.0051 0.0746 0.1349
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0047 0.0667 0.2157
Schistosoma mansoni ap endonuclease 0.002 0.0145 0.008
Schistosoma mansoni hypothetical protein 0.0041 0.0549 0.0657
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0548 0.0655
Brugia malayi hypothetical protein 0.0064 0.0984 0.1983
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0493 0.0471
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0132 0.0062
Echinococcus multilocularis ribonuclease H1 0.0023 0.0191 0.0146
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0021 0.0168 0.008
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0819 0.165
Echinococcus granulosus glycogen phosphorylase 0.0109 0.1861 0.253
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0105 0.0033
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0041 0.0545 0.046
Brugia malayi hypothetical protein 0.0041 0.0549 0.1106
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0145 0.008
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0161 0.2853 0.5672
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0145 0.0145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0544 0.0523
Trypanosoma brucei ISWI complex protein 0.0018 0.0094 0.0005
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0051 0.0746 0.0663
Trichomonas vaginalis thymidine kinase, putative 0.0533 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0145 0.0056
Schistosoma mansoni glycogen phosphorylase 0.0109 0.1861 0.253
Loa Loa (eye worm) carbonic anhydrase 3 0.0252 0.4601 0.9258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0399 0.0378
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0154 0.2711 0.5
Brugia malayi hypothetical protein 0.0271 0.4962 1
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0145 0.0123
Brugia malayi isocitrate dehydrogenase 0.0018 0.0105 0.0211
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0105 0.0211
Schistosoma mansoni hypothetical protein 0.0376 0.698 0.9834
Onchocerca volvulus 0.0064 0.0984 0.1655
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0105 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0544 0.0523
Loa Loa (eye worm) thymidylate kinase 0.0154 0.2711 0.538
Schistosoma mansoni phosphoglucomutase 0.0023 0.0191 0.0146
Trypanosoma cruzi ISWI complex protein 0.0018 0.0094 0.0005
Schistosoma mansoni bromodomain containing protein 0.0074 0.1183 0.1562
Schistosoma mansoni hypothetical protein 0.0161 0.2853 0.3945
Onchocerca volvulus Glycogen phosphorylase homolog 0.0109 0.1861 0.3486
Echinococcus granulosus Polycystic kidney disease protein 0.0064 0.0984 0.1277
Trypanosoma cruzi target of rapamycin kinase 3 0.0041 0.0545 0.046
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0252 0.4601 0.6439
Treponema pallidum thymidylate kinase (tmk) 0.0154 0.2711 1
Trypanosoma cruzi thymidine kinase, putative 0.0533 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0802 0.1018
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0981 0.3362
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0051 0.0746 0.0938
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0028 0.0286 0.0282
Onchocerca volvulus Putative thymidylate kinase 0.0154 0.2711 0.5258
Loa Loa (eye worm) hypothetical protein 0.0081 0.1314 0.2514
Echinococcus multilocularis carbonic anhydrase 0.0161 0.2853 0.3945
Leishmania major thymidylate kinase-like protein 0.0154 0.2711 0.2646
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0981 0.1273
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0382 0.7096 1
Entamoeba histolytica glycogenphosphorylase, putative 0.0047 0.0667 0.053
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0382 0.7096 1
Schistosoma mansoni zinc finger protein 0.0018 0.0094 0.0007
Brugia malayi hypothetical protein 0.0064 0.0984 0.1983
Loa Loa (eye worm) glycogen phosphorylase 0.0109 0.1861 0.3637
Loa Loa (eye worm) doublecortin family protein 0.0064 0.0984 0.1837
Giardia lamblia CDC8 0.0154 0.2711 0.2604
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0051 0.0746 0.0663
Echinococcus granulosus lipoxygenase domain containing protein 0.0064 0.0984 0.1277
Entamoeba histolytica glycogen phosphorylase, putative 0.0109 0.1861 0.1742
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0028 0.0286 0.0282
Echinococcus granulosus RUN 0.0064 0.0984 0.1277
Mycobacterium ulcerans thymidylate kinase 0.0154 0.2711 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0105 0.0016
Schistosoma mansoni hypothetical protein 0.0018 0.0094 0.0007
Echinococcus granulosus cpg binding protein 0.0034 0.0411 0.046
Brugia malayi follicle stimulating hormone receptor 0.0268 0.4908 0.989
Treponema pallidum ribonuclease H (rnhA) 0.0023 0.0191 0.018
Loa Loa (eye worm) hypothetical protein 0.0161 0.2853 0.5672
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0145 0.0056
Echinococcus multilocularis RUN 0.0064 0.0984 0.1277
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.1009 0.1314
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.039 0.043
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0342 0.0321
Trichomonas vaginalis thymidylate kinase, putative 0.0154 0.2711 0.2695
Schistosoma mansoni hypothetical protein 0.0064 0.0984 0.1277
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0602 0.058
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0228 0.014
Leishmania major ribonuclease H1, putative 0.0023 0.0191 0.0103
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0051 0.0746 0.0938
Trypanosoma brucei unspecified product 0.0024 0.0228 0.014
Trypanosoma cruzi thymidine kinase, putative 0.0533 1 1
Schistosoma mansoni loxhd1 0.0064 0.0984 0.1277
Schistosoma mansoni zinc finger protein 0.0024 0.0221 0.0189
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0145 0.0153
Brugia malayi thymidylate kinase 0.0154 0.2711 0.5463
Entamoeba histolytica glycogen phosphorylase, putative 0.0109 0.1861 0.1742
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0089 0.0179
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0132 0.0062
Trichomonas vaginalis glycogen phosphorylase, putative 0.0109 0.1861 0.1843
Echinococcus granulosus fetal alzheimer antigen falz 0.0028 0.0286 0.0282
Echinococcus multilocularis survival motor neuron protein 1 0.0271 0.4962 0.6955
Echinococcus multilocularis thymidylate kinase 0.0154 0.2711 0.3742
Echinococcus granulosus carbonic anhydrase 0.0161 0.2853 0.3945
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0549 0.0657
Chlamydia trachomatis thymidylate kinase 0.0154 0.2711 1
Schistosoma mansoni hypothetical protein 0.0376 0.698 0.9834
Onchocerca volvulus 0.0064 0.0984 0.1655
Schistosoma mansoni lipoxygenase 0.0267 0.4888 0.6848
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0252 0.4601 0.4552
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0145 0.008
Schistosoma mansoni hypothetical protein 0.0085 0.1383 0.1848
Onchocerca volvulus 0.0035 0.0427 0.0492
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0981 0.3259
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0105 0.0016
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0981 0.3259
Leishmania major hypothetical protein, conserved 0.0018 0.0094 0.0005
Brugia malayi CXXC zinc finger family protein 0.003 0.0336 0.0677
Schistosoma mansoni cpg binding protein 0.003 0.0336 0.0353
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0105 0.0016

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) > 10 uM Cytotoxicity against MT2 cells ChEMBL. 17004726
CC50 (functional) > 10 uM Cytotoxicity against MT2 cells ChEMBL. 17004726
CC50 (functional) > 50 uM Cytotoxicity against Vero cells ChEMBL. 17004726
CC50 (functional) > 100 uM Cytotoxicity against HFF cell ChEMBL. 17004726
CC50 (functional) > 100 uM Cytotoxicity against KB cells ChEMBL. 17004726
CC50 (functional) > 100 uM Cytotoxicity against Daudi cells ChEMBL. 17004726
CC50 (functional) > 100 uM Cytotoxicity against CEM cells ChEMBL. 17004726
CC50 (functional) > 100 uM Cytotoxicity against HFF cell ChEMBL. 17004726
CC50 (functional) > 100 uM Cytotoxicity against KB cells ChEMBL. 17004726
CC50 (functional) > 100 uM Cytotoxicity against Daudi cells ChEMBL. 17004726
CC50 (functional) > 100 uM Cytotoxicity against CEM cells ChEMBL. 17004726
CC50 (functional) = 183 uM Cytotoxicity against HFF cell by neutral red uptake assay ChEMBL. 17004726
CC50 (functional) = 183 uM Cytotoxicity against HFF cell by neutral red uptake assay ChEMBL. 17004726
EC50 (functional) > 10 uM Inhibition of HIV1 LAI replication in MT2 cells by cytopathic effect assay ChEMBL. 17004726
EC50 (functional) > 30 uM Inhibition of EBV replication in H1 cells by DNA hybridization assay ChEMBL. 17004726
EC50 (functional) > 30 uM Inhibition of HBV replication in 2.2.15 cells by DNA hybridization assay ChEMBL. 17004726
EC50 (functional) > 50 uM Inhibition of HSV1 replication in Vero cell by plaque reduction assay ChEMBL. 17004726
EC50 (functional) > 60 uM Inhibition of HCMV AD169 replication in HFF cells by cytopathic effect assay ChEMBL. 17004726
EC50 (functional) > 60 uM Inhibition of VZV replication in HFF cells by cytopathic effect assay ChEMBL. 17004726
EC50 (functional) = 91.6 uM Inhibition of EBV replication in Daudi cells by viral capsid antigen-ELISA ChEMBL. 17004726
EC50 (functional) > 100 uM Inhibition of HCMV towne replication in HFF cells by plaque reduction assay ChEMBL. 17004726
EC50 (functional) > 100 uM Inhibition of HSV1 replication in BSC1 cells by ELISA ChEMBL. 17004726
EC50 (functional) > 100 uM Inhibition of HSV2 replication in HFF cells by cytopathic effect assay ChEMBL. 17004726

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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