TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 251.217 | Formula: C10H10FN5O2
H donors: 3 H acceptors: 5 LogP: -0.91 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@@H]1[C@@H](/C/1=C/n1cnc2c1c(O)nc(n2)N)F
InChi: 1S/C10H10FN5O2/c11-6-4(5(6)2-17)1-16-3-13-8-7(16)9(18)15-10(12)14-8/h1,3,5-6,17H,2H2,(H3,12,14,15,18)/b4-1+/t5-,6+/m0/s1
InChiKey: QPHJZEBBTPCAJK-RJDSDSGYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	ap endonuclease	0.002	0.0145	0.008
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.029	0.0269
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0051	0.0746	0.061
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0035	0.0427	0.1171
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.029	0.0269
Trypanosoma brucei	ISWI complex protein	0.0018	0.0094	0.0005
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0064	0.0981	0.1273
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0382	0.7096	1
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0021	0.0168	0.008
Schistosoma mansoni	phosphoglucomutase	0.0023	0.0191	0.0146
Brugia malayi	Bromodomain containing protein	0.0044	0.06	0.1209
Echinococcus multilocularis	RUN	0.0064	0.0984	0.1277
Echinococcus granulosus	Polycystic kidney disease protein	0.0064	0.0984	0.1277
Onchocerca volvulus		0.0055	0.0819	0.131
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0054	0.0802	0.1018
Plasmodium falciparum	LCCL domain-containing protein	0.0064	0.0984	0.3199
Schistosoma mansoni	hypothetical protein	0.0018	0.0094	0.0007
Treponema pallidum	thymidylate kinase (tmk)	0.0154	0.2711	1
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0018	0.0105	0.0016
Trichomonas vaginalis	ribonuclease H1, putative	0.0023	0.0191	0.0169
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0047	0.0667	0.2157
Echinococcus granulosus	methyl CpG binding domain protein 2	0.002	0.0132	0.0062
Echinococcus multilocularis	zinc finger protein	0.0024	0.0221	0.0189
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0252	0.4601	0.6439
Brugia malayi	isocitrate dehydrogenase	0.0018	0.0105	0.0211
Trypanosoma brucei	thymidine kinase	0.0533	1	1
Mycobacterium ulcerans	thymidylate kinase	0.0154	0.2711	1
Echinococcus granulosus	ribonuclease H1	0.0023	0.0191	0.0146
Trypanosoma brucei	thymidylate kinase, putative	0.0154	0.2711	0.2646
Echinococcus granulosus	histone lysine methyltransferase setb	0.0054	0.0802	0.1018
Giardia lamblia	Glycogen phosphorylase	0.0109	0.1861	0.1742
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0291	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0161	0.2853	0.5672
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0427	0.0482
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0145	0.0056
Schistosoma mansoni	cpg binding protein	0.0034	0.0411	0.046
Toxoplasma gondii	thymidylate kinase	0.0154	0.2711	0.9482
Trypanosoma cruzi	UMP-CMP kinase, mitochondrial, putative	0.006	0.0916	0.0835
Schistosoma mansoni	carbonic anhydrase	0.0161	0.2853	0.3945
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0399	0.0378
Schistosoma mansoni	hypothetical protein	0.0085	0.1383	0.1848
Leishmania major	thymidine kinase, putative	0.0533	1	1
Giardia lamblia	GTOR	0.0051	0.0746	0.061
Trichomonas vaginalis	thymidine kinase, putative	0.0533	1	1
Echinococcus granulosus	zinc finger protein	0.0024	0.0221	0.0189
Echinococcus granulosus	lipoxygenase domain containing protein	0.0064	0.0984	0.1277
Schistosoma mansoni	glycogen phosphorylase	0.0047	0.0667	0.0825
Brugia malayi	Pre-SET motif family protein	0.0239	0.4351	0.8768
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0161	0.2853	0.575
Trypanosoma cruzi	thymidylate kinase, putative	0.0154	0.2711	0.2646
Echinococcus granulosus	cpg binding protein	0.0034	0.0411	0.046
Entamoeba histolytica	glycogen phosphorylase, putative	0.0109	0.1861	0.1742
Entamoeba histolytica	glycogen phosphorylase, putative	0.0047	0.0667	0.053
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0041	0.0548	0.0655
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0055	0.0819	0.165
Leishmania major	hypothetical protein, conserved	0.0018	0.0094	0.0005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0051	0.0746	0.0725
Toxoplasma gondii	aldehyde dehydrogenase	0.0064	0.0981	0.3188
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0729	0.1313
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0018	0.0105	0.0023
Schistosoma mansoni	methyl-cpg binding protein mbd	0.002	0.0132	0.0062
Entamoeba histolytica	hypothetical protein	0.0041	0.0549	0.041
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0038	0.0493	0.1412
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0051	0.0746	0.0725
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0051	0.0746	0.0938
Trypanosoma brucei	carbonic anhydrase-like protein	0.0252	0.4601	0.4552
Toxoplasma gondii	ribonuclease HI protein	0.0023	0.0191	0.0313
Brugia malayi	RNase H family protein	0.0023	0.0191	0.0384
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0109	0.1861	0.253
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0024	0.0225	0.0137
Toxoplasma gondii	hypothetical protein	0.0161	0.2853	1
Schistosoma mansoni	hypothetical protein	0.0064	0.0984	0.1277
Echinococcus granulosus	carbonic anhydrase	0.0161	0.2853	0.3945
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0041	0.0549	0.0657
Echinococcus granulosus	Glycosyl transferase family 35	0.0109	0.1861	0.253
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0544	0.0523
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0984	0.1837
Schistosoma mansoni	methyl-cpg binding protein mbd	0.002	0.0132	0.0062
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0336	0.0507
Echinococcus multilocularis	carbonic anhydrase	0.0161	0.2853	0.3945
Schistosoma mansoni	thymidylate kinase	0.0154	0.2711	0.3742
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0054	0.0802	0.1018
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0252	0.4601	0.4552
Schistosoma mansoni	aldehyde dehydrogenase	0.0064	0.0981	0.1273
Brugia malayi	hypothetical protein	0.0064	0.0984	0.1983
Echinococcus multilocularis	glycogen phosphorylase	0.0109	0.1861	0.253
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0291	0.0269
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0018	0.0105	0.0016
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0028	0.0286	0.0282
Schistosoma mansoni	phosphoglucomutase	0.0023	0.0191	0.0146
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0145	0.0115
Trypanosoma brucei	unspecified product	0.0024	0.0228	0.014
Entamoeba histolytica	hypothetical protein	0.0041	0.0549	0.041
Loa Loa (eye worm)	phosphatidylinositol 3	0.0051	0.0746	0.1349
Loa Loa (eye worm)	bromodomain containing protein	0.002	0.0146	0.0117
Entamoeba histolytica	Thymidylate kinase, putative	0.0154	0.2711	0.2604
Echinococcus multilocularis	glycogen phosphorylase	0.0109	0.1861	0.253
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0089	0.0066
Echinococcus granulosus	glycogen phosphorylase	0.0109	0.1861	0.253
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0064	0.0981	0.1273
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.0981	0.3259
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0109	0.1861	0.1843
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0018	0.0105	0.0033
Schistosoma mansoni	carbonic anhydrase-related	0.0161	0.2853	0.3945
Schistosoma mansoni	hypothetical protein	0.0161	0.2853	0.3945
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0089	0.0066
Brugia malayi	RNase H family protein	0.0023	0.0191	0.0384
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0145	0.0153
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0064	0.0981	0.09
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0089	0.0066
Schistosoma mansoni	hypothetical protein	0.0376	0.698	0.9834
Trypanosoma cruzi	ISWI complex protein	0.0018	0.0094	0.0005
Loa Loa (eye worm)	PHD-finger family protein	0.0024	0.0211	0.0251
Leishmania major	carbonic anhydrase-like protein	0.0252	0.4601	0.4552
Trypanosoma cruzi	ribonuclease H1, putative	0.0023	0.0191	0.0103
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0161	0.2853	0.575
Chlamydia trachomatis	thymidylate kinase	0.0154	0.2711	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0035	0.0427	0.0482
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0342	0.0321
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.0981	0.3259
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0145	0.0153
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0051	0.0746	0.0663
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0105	0.0023
Brugia malayi	hypothetical protein	0.0064	0.0984	0.1983
Loa Loa (eye worm)	hypothetical protein	0.0161	0.2853	0.5672
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0051	0.0746	0.0663
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0493	0.0471
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0035	0.0427	0.0482
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0161	0.2853	0.575
Echinococcus granulosus	fetal alzheimer antigen falz	0.0028	0.0286	0.0282
Schistosoma mansoni	survival motor neuron protein	0.0055	0.0819	0.1042
Brugia malayi	Doublecortin family protein	0.0064	0.0984	0.1983
Echinococcus multilocularis	carbonic anhydrase	0.0161	0.2853	0.3945
Schistosoma mansoni	rab6-interacting	0.0064	0.0984	0.1277
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.0981	0.3259
Onchocerca volvulus		0.0272	0.4984	1
Loa Loa (eye worm)	thymidylate kinase	0.0154	0.2711	0.538
Schistosoma mansoni	hypothetical protein	0.0041	0.0549	0.0657
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0145	0.0056
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0252	0.4601	0.4552
Leishmania major	hypothetical protein, conserved	0.006	0.0916	0.0835
Schistosoma mansoni	zinc finger protein	0.0018	0.0094	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0984	0.1837
Trypanosoma brucei	ribonuclease H1	0.0023	0.0191	0.0103
Trypanosoma brucei	hypothetical protein, conserved	0.0024	0.0228	0.014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0602	0.058
Entamoeba histolytica	glycogen phosphorylase, putative	0.0109	0.1861	0.1742
Brugia malayi	Pre-SET motif family protein	0.0035	0.0427	0.086
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0654	0.1159
Trichomonas vaginalis	thymidylate kinase, putative	0.0154	0.2711	0.2695
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0028	0.0286	0.0282
Trypanosoma cruzi	ribonuclease H1, putative	0.0023	0.0191	0.0103
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0041	0.0549	0.0657
Echinococcus granulosus	carbonic anhydrase	0.0161	0.2853	0.3945
Schistosoma mansoni	phosphoglucomutase	0.0023	0.0191	0.0146
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0051	0.0746	0.0938
Schistosoma mansoni	hypothetical protein	0.0055	0.0819	0.1042
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0382	0.7096	1
Echinococcus multilocularis	carbonic anhydrase II	0.0252	0.4601	0.6439
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0342	0.0321
Trypanosoma cruzi	ISWI complex protein	0.0018	0.0094	0.0005
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0051	0.0746	0.0663
Brugia malayi	hypothetical protein	0.0041	0.0549	0.1106
Brugia malayi	Bromodomain containing protein	0.0088	0.1441	0.2904
Brugia malayi	hypothetical protein	0.0271	0.4962	1
Loa Loa (eye worm)	hypothetical protein	0.0161	0.2853	0.5672
Echinococcus multilocularis	carbonic anhydrase	0.0161	0.2853	0.3945
Brugia malayi	RNase H family protein	0.0023	0.0191	0.0384
Echinococcus granulosus	glycogen phosphorylase	0.0109	0.1861	0.253
Schistosoma mansoni	lipoxygenase	0.0267	0.4888	0.6848
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0033	0.039	0.043
Entamoeba histolytica	glycogen phosphorylase, putative	0.0047	0.0667	0.053
Trypanosoma brucei	thymidylate kinase, putative	0.0154	0.2711	0.2646
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0145	0.0056
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0054	0.0802	0.1018
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0291	0.0269
Wolbachia endosymbiont of Brugia malayi	thymidylate kinase	0.0154	0.2711	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0544	0.0523
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0145	0.0123
Loa Loa (eye worm)	carbonic anhydrase 3	0.0252	0.4601	0.9258
Echinococcus granulosus	carbonic anhydrase	0.0161	0.2853	0.3945
Echinococcus multilocularis	Polycystic kidney disease protein	0.0064	0.0984	0.1277
Echinococcus granulosus	carbonic anhydrase II	0.0252	0.4601	0.6439
Trypanosoma brucei	ingi protein (ORF1)	0.0024	0.0228	0.014
Giardia lamblia	Ribonuclease H	0.0023	0.0191	0.0047
Onchocerca volvulus	Putative thymidylate kinase	0.0154	0.2711	0.5258
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0041	0.0545	0.046
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0802	0.1464
Schistosoma mansoni	carbonic anhydrase-related	0.0161	0.2853	0.3945
Giardia lamblia	CDC8	0.0154	0.2711	0.2604
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0161	0.2853	0.5672
Schistosoma mansoni	loxhd1	0.0064	0.0984	0.1277
Entamoeba histolytica	hypothetical protein	0.0041	0.0549	0.041
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0064	0.0984	0.1277
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0544	0.0523
Treponema pallidum	ribonuclease H (rnhA)	0.0023	0.0191	0.018
Schistosoma mansoni	cpg binding protein	0.003	0.0336	0.0353
Entamoeba histolytica	hypothetical protein	0.0041	0.0549	0.041
Trichomonas vaginalis	thymidine kinase, putative	0.0533	1	1
Schistosoma mansoni	zinc finger protein	0.0024	0.0221	0.0189
Trypanosoma brucei	RNA helicase, putative	0.0085	0.1383	0.1306
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0051	0.0746	0.0663
Loa Loa (eye worm)	doublecortin family protein	0.0064	0.0984	0.1837
Schistosoma mansoni	transcription factor LCR-F1	0.0041	0.0549	0.0657
Echinococcus multilocularis	isocitrate dehydrogenase	0.0018	0.0105	0.0023
Echinococcus multilocularis	geminin	0.0376	0.698	0.9834
Plasmodium vivax	multidomain scavenger receptor, putative	0.0064	0.0984	0.3373
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0109	0.1861	0.3486
Onchocerca volvulus		0.0064	0.0984	0.1655
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0105	0.0023
Echinococcus granulosus	thymidylate kinase	0.0154	0.2711	0.3742
Trypanosoma brucei	retrotransposon hot spot protein 4 (RHS4), interrupted	0.0024	0.0228	0.014
Trypanosoma cruzi	thymidine kinase, putative	0.0533	1	1
Schistosoma mansoni	thymidylate kinase	0.0154	0.2711	0.3742
Plasmodium vivax	thymidylate kinase, putative	0.0154	0.2711	1
Schistosoma mansoni	hypothetical protein	0.0154	0.2711	0.3742
Loa Loa (eye worm)	glycogen phosphorylase	0.0109	0.1861	0.3637
Trichomonas vaginalis	thymidine kinase, putative	0.0533	1	1
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.002	0.0132	0.0062
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0051	0.0746	0.0663
Trypanosoma cruzi	UMP-CMP kinase, mitochondrial, putative	0.006	0.0916	0.0835
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.007	0.1104	0.1449
Echinococcus multilocularis	ribonuclease H1	0.0023	0.0191	0.0146
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0105	0.0023
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0252	0.4601	0.9271
Schistosoma mansoni	hypothetical protein	0.0059	0.0895	0.1151
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0493	0.0471
Giardia lamblia	Thymidine kinase	0.0533	1	1
Schistosoma mansoni	hypothetical protein	0.0024	0.0211	0.0175
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0421	0.0399
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0145	0.0291
Schistosoma mansoni	hypothetical protein	0.0376	0.698	0.9834
Plasmodium falciparum	thymidylate kinase	0.0154	0.2711	0.9482
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0252	0.4601	0.9258
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0161	0.2853	0.575
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0018	0.0105	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0271	0.4962	1
Brugia malayi	CXXC zinc finger family protein	0.003	0.0336	0.0677
Brugia malayi	thymidylate kinase	0.0154	0.2711	0.5463
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0051	0.0746	0.1504
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0017	0.0089	0.0179
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0291	0.0269
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0018	0.0105	0.0016
Schistosoma mansoni	ap endonuclease	0.002	0.0145	0.008
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0239	0.4351	0.8746
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0065	0.1009	0.1314
Plasmodium vivax	SET domain protein, putative	0.0035	0.0427	0.1235
Brugia malayi	Isocitrate dehydrogenase	0.0018	0.0105	0.0211
Schistosoma mansoni	glycogen phosphorylase	0.0109	0.1861	0.253
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0493	0.0471
Toxoplasma gondii	exonuclease III APE	0.002	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0602	0.1052
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0089	0.0066
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0051	0.0746	0.0725
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0493	0.0471
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0041	0.0545	0.046
Schistosoma mansoni	polycystin 1-related	0.0064	0.0984	0.1277
Giardia lamblia	Deoxynucleoside kinase	0.0379	0.7038	0.6995
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0544	0.0523
Echinococcus granulosus	lipoxygenase domain containing protein	0.0064	0.0984	0.1277
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0109	0.1861	0.1843
Loa Loa (eye worm)	hypothetical protein	0.0081	0.1314	0.2514
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0145	0.008
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.007	0.1104	0.1449
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0061	0.093	0.3003
Trichomonas vaginalis	set domain proteins, putative	0.0272	0.4984	0.4973
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0493	0.0471
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0018	0.0105	0.0023
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0041	0.0548	0.0655
Schistosoma mansoni	bromodomain containing protein	0.0074	0.1183	0.1562
Brugia malayi	carbohydrate phosphorylase	0.0109	0.1861	0.3751
Mycobacterium leprae	probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK)	0.0154	0.2711	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0268	0.4908	0.9888
Wolbachia endosymbiont of Brugia malayi	ribonuclease HI	0.0023	0.0191	0.018
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0145	0.0123
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0252	0.4601	0.9271
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0064	0.0984	0.1277
Echinococcus granulosus	survival motor neuron protein 1	0.0271	0.4962	0.6955
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0018	0.0105	0.0023
Trypanosoma brucei	ingi protein (ORF1)	0.0024	0.0228	0.014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0493	0.0471
Schistosoma mansoni	aldehyde dehydrogenase	0.0064	0.0981	0.1273
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.029	0.0269
Trichomonas vaginalis	thymidylate kinase, putative	0.0154	0.2711	0.2695
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0493	0.0471
Onchocerca volvulus		0.003	0.0336	0.0303
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0089	0.0066
Schistosoma mansoni	cpg binding protein	0.0034	0.0411	0.046
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0348	0.0326
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0145	0.008
Brugia malayi	follicle stimulating hormone receptor	0.0268	0.4908	0.989
Echinococcus multilocularis	thymidylate kinase	0.0154	0.2711	0.3742
Trypanosoma cruzi	target of rapamycin kinase 3	0.0041	0.0545	0.046
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0051	0.0746	0.0663
Echinococcus multilocularis	cpg binding protein	0.0034	0.0411	0.046
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0051	0.0746	0.0938
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0348	0.0326
Mycobacterium tuberculosis	Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK)	0.0154	0.2711	1
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0018	0.0105	0.0016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0348	0.0326
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0252	0.4601	0.6439
Entamoeba histolytica	glycogenphosphorylase, putative	0.0047	0.0667	0.053
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0544	0.0523
Plasmodium falciparum	carbonic anhydrase	0.0161	0.2853	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0051	0.0746	0.061
Echinococcus granulosus	geminin	0.0376	0.698	0.9834
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0161	0.2853	0.575
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0145	0.0145
Trypanosoma cruzi	thymidine kinase, putative	0.0533	1	1
Onchocerca volvulus		0.0035	0.0427	0.0492
Brugia malayi	PHD-finger family protein	0.003	0.0338	0.0682
Trypanosoma cruzi	thymidylate kinase, putative	0.0154	0.2711	0.2646
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0145	0.0056
Schistosoma mansoni	rab6-interacting	0.0064	0.0984	0.1277
Schistosoma mansoni	glycogen phosphorylase	0.0109	0.1861	0.253
Schistosoma mansoni	lipoxygenase	0.0382	0.7096	1
Schistosoma mansoni	carbonic anhydrase-related	0.0161	0.2853	0.3945
Leishmania major	thymidylate kinase-like protein	0.0154	0.2711	0.2646
Leishmania major	ribonuclease H1, putative	0.0023	0.0191	0.0103
Echinococcus multilocularis	survival motor neuron protein 1	0.0271	0.4962	0.6955
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0047	0.0667	0.2035
Echinococcus granulosus	RUN	0.0064	0.0984	0.1277
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0064	0.0981	0.3362
Onchocerca volvulus		0.0064	0.0984	0.1655

Activities

Activity type	Activity value	Assay description	Source	Reference
CC50 (functional)	> 10 uM	Cytotoxicity against MT2 cells	ChEMBL.	17004726
CC50 (functional)	> 10 uM	Cytotoxicity against MT2 cells	ChEMBL.	17004726
CC50 (functional)	> 50 uM	Cytotoxicity against Vero cells	ChEMBL.	17004726
CC50 (functional)	= 74 uM	Cytotoxicity against CEM cells	ChEMBL.	17004726
CC50 (functional)	= 74 uM	Cytotoxicity against CEM cells	ChEMBL.	17004726
CC50 (functional)	> 100 uM	Cytotoxicity against HFF cell	ChEMBL.	17004726
CC50 (functional)	> 100 uM	Cytotoxicity against KB cells	ChEMBL.	17004726
CC50 (functional)	> 100 uM	Cytotoxicity against Daudi cells	ChEMBL.	17004726
CC50 (functional)	> 100 uM	Cytotoxicity against HFF cell	ChEMBL.	17004726
CC50 (functional)	> 100 uM	Cytotoxicity against KB cells	ChEMBL.	17004726
CC50 (functional)	> 100 uM	Cytotoxicity against Daudi cells	ChEMBL.	17004726
CC50 (functional)	> 300 uM	Cytotoxicity against HFF cell by neutral red uptake assay	ChEMBL.	17004726
CC50 (functional)	> 300 uM	Cytotoxicity against HFF cell by neutral red uptake assay	ChEMBL.	17004726
EC50 (functional)	= 2.9 uM	Inhibition of HCMV towne replication in HFF cells by plaque reduction assay	ChEMBL.	17004726
EC50 (functional)	> 10 uM	Inhibition of HIV1 LAI replication in MT2 cells by cytopathic effect assay	ChEMBL.	17004726
EC50 (functional)	> 12 uM	Inhibition of HCMV AD169 replication in HFF cells by cytopathic effect assay	ChEMBL.	17004726
EC50 (functional)	= 13 uM	Inhibition of EBV replication in H1 cells by DNA hybridization assay	ChEMBL.	17004726
EC50 (functional)	> 20 uM	Inhibition of HBV replication in 2.2.15 cells by DNA hybridization assay	ChEMBL.	17004726
EC50 (functional)	> 50 uM	Inhibition of HSV1 replication in Vero cell by plaque reduction assay	ChEMBL.	17004726
EC50 (functional)	= 70 uM	Inhibition of HSV1 replication in BSC1 cells by ELISA	ChEMBL.	17004726
EC50 (functional)	> 100 uM	Inhibition of HSV2 replication in HFF cells by cytopathic effect assay	ChEMBL.	17004726
EC50 (functional)	> 100 uM	Inhibition of EBV replication in Daudi cells by viral capsid antigen-ELISA	ChEMBL.	17004726
EC50 (functional)	> 100 uM	Inhibition of VZV replication in HFF cells by plaque reduction assay	ChEMBL.	17004726

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL383977

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 374576