Detailed information for compound 379012

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1467.74 | Formula: C54H106N12O26S4
  • H donors: 24 H acceptors: 12 LogP: -15.14 Rotable bonds: 33
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCC1OC(OC2C(CSCCOCCSSCCOCCSCC3OC(C(C3OC3OC(CN)C(C(C3N)O)O)O)OC3C(O)C(N)CC(C3OC3OC(CN)C(C(C3N)O)O)N)OC(C2O)OC2C(O)C(N)CC(C2OC2OC(CN)C(C(C2N)O)O)N)C(C(C1O)O)N
  • InChi: 1S/C54H106N12O26S4/c55-11-21-33(69)37(73)27(63)49(81-21)87-43-19(61)9-17(59)31(67)47(43)91-53-41(77)45(89-51-29(65)39(75)35(71)23(13-57)83-51)25(85-53)15-93-5-1-79-3-7-95-96-8-4-80-2-6-94-16-26-46(90-52-30(66)40(76)36(72)24(14-58)84-52)42(78)54(86-26)92-48-32(68)18(60)10-20(62)44(48)88-50-28(64)38(74)34(70)22(12-56)82-50/h17-54,67-78H,1-16,55-66H2
  • InChiKey: AVTMARLPEJHNSQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum thioredoxin reductase 0.0047 0.0077 0.4378
Plasmodium falciparum diacylglycerol kinase, putative 0.0059 0.0163 1
Echinococcus granulosus geminin 0.0169 0.0895 0.0895
Leishmania major cytochrome p450-like protein 0.0036 0.0003 0.0039
Brugia malayi G-protein coupled receptor 0.0131 0.0646 0.2935
Brugia malayi Dopamine receptor protein 2 0.0131 0.0646 0.2935
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Echinococcus granulosus tar DNA binding protein 0.0128 0.0621 0.0621
Loa Loa (eye worm) glutathione reductase 0.0047 0.0077 0.0077
Brugia malayi diacylglycerol kinase 0.0059 0.0163 0.0739
Brugia malayi hypothetical protein 0.0073 0.0256 0.1163
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Brugia malayi GnHR receptor homolog 0.0131 0.0646 0.2935
Loa Loa (eye worm) cytochrome P450 family protein 0.0112 0.0517 0.0517
Brugia malayi Ceramide kinase 0.0059 0.0163 0.0739
Brugia malayi follicle stimulating hormone receptor 0.0363 0.2201 1
Brugia malayi Cytochrome P450 family protein 0.0053 0.0121 0.0549
Brugia malayi hypothetical protein 0.0131 0.0646 0.2935
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0059 0.0163 0.1032
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0163 0.1032
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0122 0.0583 0.0583
Schistosoma mansoni opsin-like receptor 0.0131 0.0646 0.0646
Toxoplasma gondii hypothetical protein 0.0039 0.0025 0.0513
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0131 0.0646 0.0646
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0059 0.0163 0.0163
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0186 0.0186
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0054 0.0125 0.0795
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0621 0.0621
Brugia malayi neuropeptide F receptor 0.0131 0.0646 0.2935
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Leishmania major cytochrome p450-like protein 0.0036 0.0003 0.0039
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0011 0.0011
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.0828 0.3761
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0135 0.0671 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.0671 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Echinococcus multilocularis neuropeptide receptor A26 0.0577 0.3632 0.3632
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0131 0.0646 0.0646
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0054 0.0125 0.057
Loa Loa (eye worm) hypothetical protein 0.0059 0.0163 0.0163
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Onchocerca volvulus 0.0092 0.0379 0.448
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0131 0.0646 0.2935
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.0671 1
Trypanosoma cruzi Sphingosine kinase 0.0059 0.0163 0.2426
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Plasmodium vivax diacylglycerol kinase, putative 0.0059 0.0163 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0201 0.0201
Trypanosoma brucei trypanothione reductase 0.0047 0.0077 0.1151
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0646 0.0646
Echinococcus multilocularis GPCR, family 2 0.0063 0.0186 0.0186
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0011 0.0011
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.0558 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0805 0.5165 0.5165
Trichomonas vaginalis sphingosine kinase, putative 0.0059 0.0163 0.1032
Schistosoma mansoni neuropeptide receptor 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Brugia malayi hypothetical protein 0.0131 0.0646 0.2935
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.0583 0.3696
Onchocerca volvulus 0.0131 0.0646 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0201 0.2996
Plasmodium vivax diacylglycerol kinase, putative 0.0059 0.0163 1
Brugia malayi Cytochrome P450 family protein 0.0036 0.0003 0.0012
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Brugia malayi G protein-coupled receptor 0.0131 0.0646 0.2935
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0054 0.0125 0.0125
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0136 0.0677 0.0677
Schistosoma mansoni hypothetical protein 0.0169 0.0895 0.0895
Echinococcus granulosus hypothetical protein 0.0131 0.0646 0.0646
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0131 0.0646 0.0646
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0478 0.0476
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0199 0.1099 0.1099
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Trichomonas vaginalis glutaminase, putative 0.027 0.1576 1
Leishmania major trypanothione reductase 0.0047 0.0077 0.1151
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0122 0.0583 0.3696
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0131 0.0646 0.0646
Echinococcus multilocularis fmrfamide receptor 0.0131 0.0646 0.0646
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0054 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0186 0.0847
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0025 0.0022
Echinococcus granulosus tm gpcr rhodopsin 0.0131 0.0646 0.0646
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0131 0.0646 0.0646
Loa Loa (eye worm) TAR-binding protein 0.0128 0.0621 0.0621
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Schistosoma mansoni neuropeptide receptor 0.0131 0.0646 0.0646
Echinococcus granulosus neuropeptide receptor 0.0131 0.0646 0.0646
Onchocerca volvulus 0.0131 0.0646 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Schistosoma mansoni hypothetical protein 0.0073 0.0256 0.0256
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0478 0.0476
Onchocerca volvulus 0.0131 0.0646 1
Schistosoma mansoni biogenic amine receptor 0.0131 0.0646 0.0646
Onchocerca volvulus 0.0131 0.0646 1
Trypanosoma cruzi diacylglycerol kinase, putative 0.0059 0.0163 0.2426
Echinococcus granulosus g protein coupled receptor 0.0131 0.0646 0.0646
Brugia malayi hypothetical protein 0.0131 0.0646 0.2935
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0077 0.0077
Echinococcus granulosus g-protein coupled receptor 0.0131 0.0646 0.0646
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0131 0.0646 0.0646
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.0671 1
Schistosoma mansoni amine GPCR 0.0131 0.0646 0.0646
Toxoplasma gondii hypothetical protein 0.0107 0.0482 1
Entamoeba histolytica hypothetical protein, conserved 0.1526 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0131 0.0646 0.0646
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0256 0.0256
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0131 0.0646 0.0646
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0131 0.0646 0.0646
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0039 0.0025 0.0022
Entamoeba histolytica hypothetical protein 0.0073 0.0256 0.0256
Brugia malayi TAR-binding protein 0.0128 0.0621 0.2823
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Leishmania major cytochrome p450-like protein 0.0053 0.0121 0.1801
Brugia malayi G protein-coupled receptor F59B2.13 0.0131 0.0646 0.2935
Brugia malayi hypothetical protein 0.0131 0.0646 0.2935
Brugia malayi diacylglycerol kinase 0.0059 0.0163 0.0739
Onchocerca volvulus 0.0131 0.0646 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Brugia malayi hypothetical protein 0.0131 0.0646 0.2935
Echinococcus multilocularis dro:myosuppressin receptor 0.0131 0.0646 0.0646
Echinococcus multilocularis orexin receptor type 2 0.0131 0.0646 0.0646
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0186 0.0847
Echinococcus granulosus tm gpcr rhodopsin 0.0131 0.0646 0.0646
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0011 0.0011
Echinococcus granulosus fmrfamide receptor 0.0131 0.0646 0.0646
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0131 0.0646 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Toxoplasma gondii GAF domain-containing protein 0.0039 0.0025 0.0513
Schistosoma mansoni hypothetical protein 0.0036 0.0003 0.0003
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0011 0.5
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Schistosoma mansoni alpha-glucosidase 0.0136 0.068 0.068
Onchocerca volvulus 0.0131 0.0646 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0122 0.0583 0.3696
Mycobacterium tuberculosis Probable reductase 0.0107 0.0478 0.0476
Schistosoma mansoni alpha-glucosidase 0.0136 0.068 0.068
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0083 0.0322 0.4798
Schistosoma mansoni hypothetical protein 0.0131 0.0646 0.0646
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0059 0.0163 0.3376
Brugia malayi hypothetical protein 0.0131 0.0646 0.2935
Echinococcus multilocularis g protein coupled receptor 0.0131 0.0646 0.0646
Trichomonas vaginalis diacylglycerol kinase, putative 0.0059 0.0163 0.1032
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0122 0.0583 0.3696
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0646 0.0646
Brugia malayi neuropeptide F receptor 0.0131 0.0646 0.2935
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0646 0.0646
Loa Loa (eye worm) glutaminase 0.027 0.1576 0.1576
Schistosoma mansoni opsin-like receptor 0.0131 0.0646 0.0646
Echinococcus granulosus tachykinin peptides receptor 99D 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0059 0.0163 0.1032
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0054 0.0125 0.057
Brugia malayi glutathione reductase 0.0047 0.0077 0.0351
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0083 0.0322 0.2042
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0011 0.5
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Schistosoma mansoni adenoreceptor 0.0131 0.0646 0.0646
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Trichomonas vaginalis sphingosine kinase, putative 0.0059 0.0163 0.1032
Loa Loa (eye worm) G-protein coupled receptor 0.0131 0.0646 0.0646
Brugia malayi Cytochrome P450 family protein 0.0112 0.0517 0.2351
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0122 0.0583 0.8687
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0017 0.0017
Schistosoma mansoni cytochrome P450 0.0036 0.0003 0.0003
Onchocerca volvulus 0.0131 0.0646 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0122 0.0583 0.3696
Echinococcus granulosus peptide allatostatin:somatostatin 0.0131 0.0646 0.0646
Onchocerca volvulus 0.0131 0.0646 1
Echinococcus granulosus serotonin receptor 0.0131 0.0646 0.0646
Trypanosoma brucei diacylglycerol kinase, putative 0.0059 0.0163 0.2426
Echinococcus granulosus neuropeptide receptor A26 0.0577 0.3632 0.3632
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0478 0.0476
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0025 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0167 0.0885 0.5619
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0036 0.0003 0.0039
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0025 0.0929
Schistosoma mansoni growth hormone secretagogue receptor 0.0131 0.0646 0.0646
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0131 0.0646 0.0646
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0125 0.0795
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0131 0.0646 0.2935
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Trichomonas vaginalis diacylglycerol kinase, putative 0.0059 0.0163 0.1032
Entamoeba histolytica diacylglycerol kinase, putative 0.0059 0.0163 0.0163
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0131 0.0646 0.0646
Onchocerca volvulus 0.0131 0.0646 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0131 0.0646 0.0646
Echinococcus granulosus g protein coupled receptor 0.0131 0.0646 0.0646
Schistosoma mansoni hypothetical protein 0.0063 0.0186 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0482 0.3058
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0131 0.0646 0.0646
Loa Loa (eye worm) neuropeptide F receptor 0.0131 0.0646 0.0646
Entamoeba histolytica diacylglycerol kinase, putative 0.0059 0.0163 0.0163
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0646 0.0646
Trypanosoma brucei hypothetical protein 0.0135 0.0671 1
Brugia malayi RNA binding protein 0.0128 0.0621 0.2823
Brugia malayi Dopamine receptor protein 1 0.0131 0.0646 0.2935
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0135 0.0671 1
Echinococcus multilocularis neuropeptides capa receptor 0.0131 0.0646 0.0646
Trypanosoma brucei calpain, putative 0.0135 0.0671 1
Brugia malayi hypothetical protein 0.0059 0.0163 0.0739
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0256 0.0256
Plasmodium falciparum diacylglycerol kinase, putative 0.0059 0.0163 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0131 0.0646 0.0646
Schistosoma mansoni hypothetical protein 0.0169 0.0895 0.0895
Echinococcus multilocularis ceramide kinase 0.0059 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.1526 1 1
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0011 0.0067
Loa Loa (eye worm) melatonin receptor type 1A 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.0671 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0011 0.0158
Onchocerca volvulus 0.0131 0.0646 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0125 0.0125
Brugia malayi Diacylglycerol kinase protein 2 0.0059 0.0163 0.0739
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.0558 0.0556
Echinococcus granulosus neuropeptides capa receptor 0.0131 0.0646 0.0646
Echinococcus granulosus g protein coupled receptor 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Brugia malayi Calcitonin receptor-like protein seb-1 0.0199 0.1099 0.4995
Echinococcus granulosus GPCR family 2 0.0063 0.0186 0.0186
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0077 0.4378
Schistosoma mansoni sphingoid long chain base kinase 0.1526 1 1
Echinococcus multilocularis fmrfamide receptor 0.0131 0.0646 0.0646
Loa Loa (eye worm) diacylglycerol kinase 2 0.0059 0.0163 0.0163
Trypanosoma cruzi diacylglycerol kinase, putative 0.0059 0.0163 0.2426
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0186 0.0186
Schistosoma mansoni hypothetical protein 0.0063 0.0186 0.0186
Brugia malayi Tachykinin-like peptides receptor 99D 0.0131 0.0646 0.2935
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0201 0.2996
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0059 0.0163 0.2426
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0131 0.0646 0.0646
Brugia malayi larval opioid receptor 0.0131 0.0646 0.2935
Onchocerca volvulus 0.0131 0.0646 1
Schistosoma mansoni ap endonuclease 0.0037 0.0011 0.0011
Schistosoma mansoni neuropeptide F-like receptor 0.0131 0.0646 0.0646
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0059 0.0163 0.1032
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0131 0.0646 0.0646
Schistosoma mansoni hypothetical protein 0.0063 0.0186 0.0186
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0011 0.0158
Schistosoma mansoni amine GPCR 0.0131 0.0646 0.0646
Brugia malayi G-protein coupled receptor 0.0131 0.0646 0.2935
Echinococcus multilocularis neuropeptide FF receptor 2 0.0131 0.0646 0.0646
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0059 0.0163 0.0163
Brugia malayi hypothetical protein 0.0131 0.0646 0.2935
Toxoplasma gondii hypothetical protein 0.0039 0.0025 0.0513
Schistosoma mansoni opsin-like receptor 0.0131 0.0646 0.0646
Echinococcus multilocularis g-protein coupled receptor 0.0131 0.0646 0.0646
Mycobacterium ulcerans hypothetical protein 0.1526 1 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0131 0.0646 0.0646
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0478 0.0476
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0131 0.0646 0.0646
Brugia malayi Cytochrome P450 family protein 0.0053 0.0121 0.0549
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0059 0.0163 0.3376
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.0558 0.0556
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0011 0.0158
Schistosoma mansoni glutaminase 0.027 0.1576 0.1576
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.0677 0.3075
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0039 0.0025 0.0022
Mycobacterium ulcerans diacylglycerol kinase 0.0059 0.0163 0.016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Onchocerca volvulus 0.0131 0.0646 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0122 0.0583 0.3696
Brugia malayi hypothetical protein 0.0131 0.0646 0.2935
Loa Loa (eye worm) hypothetical protein 0.0199 0.1099 0.1099
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0131 0.0646 0.0646
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0131 0.0646 0.0646
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0011 0.0048
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0036 0.0003 0.0039
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0122 0.0583 0.0583
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0201 0.0201
Leishmania major sphingosine kinase A, B, putative 0.0059 0.0163 0.2426
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0122 0.0583 0.8687
Schistosoma mansoni diacylglycerol kinase theta 0.0059 0.0163 0.0163
Schistosoma mansoni amine GPCR 0.0131 0.0646 0.0646
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Brugia malayi glutaminase DH11.1 0.027 0.1576 0.7161
Trypanosoma cruzi cytochrome P450, putative 0.0053 0.0121 0.1801
Echinococcus granulosus neuropeptide s receptor 0.0577 0.3632 0.3632
Brugia malayi cytochrome P450 0.0036 0.0003 0.0012
Echinococcus multilocularis tar DNA binding protein 0.0128 0.0621 0.0621
Schistosoma mansoni neuropeptide F-like receptor 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Echinococcus granulosus orexin receptor type 2 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Echinococcus granulosus 7TM GPCR rhodopsin 0.0131 0.0646 0.0646
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0122 0.0583 0.8687
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0059 0.0163 0.0163
Echinococcus granulosus Diacylglycerol kinase zeta 0.0059 0.0163 0.0163
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Loa Loa (eye worm) glutaminase 2 0.027 0.1576 0.1576
Toxoplasma gondii cytochrome p450 superfamily protein 0.0036 0.0003 0.0054
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Echinococcus multilocularis neuropeptide Y receptor 0.0131 0.0646 0.0646
Trypanosoma brucei cytochrome P450, putative 0.0053 0.0121 0.1801
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0478 0.8565
Onchocerca volvulus Neuropeptide F receptor homolog 0.0131 0.0646 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0363 0.2201 0.2201
Plasmodium falciparum glutathione reductase 0.0047 0.0077 0.4378
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0621 0.0621
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0131 0.0646 0.0646
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0036 0.0003 0.0039
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0621 0.0621
Brugia malayi hypothetical protein 0.0131 0.0646 0.2935
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0646 0.0646
Schistosoma mansoni hypothetical protein 0.0063 0.0186 0.0186
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0122 0.0583 0.3696
Brugia malayi Serotonin receptor 0.0131 0.0646 0.2935
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Schistosoma mansoni hypothetical protein 0.0059 0.0163 0.0163
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0646 0.0646
Schistosoma mansoni biogenic amine (5HT) receptor 0.0131 0.0646 0.0646
Echinococcus granulosus ceramide kinase 0.0059 0.0163 0.0163
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0077 0.1151
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Mycobacterium tuberculosis Conserved protein 0.1526 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0131 0.0646 0.0646
Echinococcus multilocularis serotonin receptor 0.0131 0.0646 0.0646
Schistosoma mansoni alpha-1 adrenergic receptor 0.0131 0.0646 0.0646
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0201 0.0201
Echinococcus granulosus somatostatin receptor 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Echinococcus granulosus neuropeptide Y receptor 0.0131 0.0646 0.0646
Leishmania major hypothetical protein, conserved 0.0059 0.0163 0.2426
Schistosoma mansoni amine GPCR 0.0131 0.0646 0.0646
Schistosoma mansoni myosin xvIII 0.0131 0.0646 0.0646
Trypanosoma brucei hypothetical protein, conserved 0.0059 0.0163 0.2426
Entamoeba histolytica diacylglycerol kinase, putative 0.0059 0.0163 0.0163
Echinococcus granulosus tm gpcr rhodopsin 0.0131 0.0646 0.0646
Brugia malayi AKH receptor 0.0131 0.0646 0.2935
Entamoeba histolytica hypothetical protein 0.0073 0.0256 0.0256
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0122 0.0583 0.3696
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0011 0.0011
Echinococcus multilocularis allatostatin A receptor 0.0131 0.0646 0.0646
Schistosoma mansoni hypothetical protein 0.0131 0.0646 0.0646
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0059 0.0163 0.2426
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0059 0.0163 0.2426
Loa Loa (eye worm) hypothetical protein 0.0063 0.0186 0.0186
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0621 0.0621
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0122 0.0583 0.3696
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0131 0.0646 0.0646
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0011 0.5
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0122 0.0583 0.8687
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0186 0.0186
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0131 0.0646 0.0646
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0131 0.0646 0.0646
Schistosoma mansoni sphingosine kinase A B 0.1526 1 1
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0135 0.0671 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0131 0.0646 0.0646
Leishmania major diacylglycerol kinase, putative 0.0059 0.0163 0.2426
Toxoplasma gondii exonuclease III APE 0.0037 0.0011 0.022
Trichomonas vaginalis bmru protein, putative 0.0059 0.0163 0.1032
Trypanosoma cruzi cytochrome P450, putative 0.0053 0.0121 0.1801
Toxoplasma gondii diacylglycerol kinase, putative 0.0059 0.0163 0.3376
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0201 0.0201
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0122 0.0583 0.8687
Loa Loa (eye worm) ceramide kinase 0.0059 0.0163 0.0163
Loa Loa (eye worm) G-protein coupled receptor 0.0131 0.0646 0.0646
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0131 0.0646 0.0646
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0482 0.3058
Echinococcus granulosus G protein coupled receptor 139 0.0131 0.0646 0.0646
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0136 0.0677 0.0677
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0186 0.0186
Brugia malayi Melatonin receptor type 1A 0.0131 0.0646 0.2935
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0131 0.0646 0.0646
Schistosoma mansoni neuropeptide receptor 0.0131 0.0646 0.0646
Loa Loa (eye worm) CYP4Cod1 0.0053 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0059 0.0163 0.0163
Brugia malayi putative neuropeptide receptor NPR1 0.0131 0.0646 0.2935
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0646 0.0646
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0201 0.2996
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0025 0.0398
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0131 0.0646 0.0646
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.0558 0.0556
Echinococcus multilocularis neuropeptide receptor 0.0131 0.0646 0.0646
Echinococcus granulosus neuropeptide FF receptor 2 0.0131 0.0646 0.0646
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.0671 1
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0036 0.0003 0.0039
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.0671 1
Echinococcus multilocularis neuropeptide Y receptor 0.0131 0.0646 0.0646
Echinococcus multilocularis g protein coupled receptor 0.0131 0.0646 0.0646
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0077 0.0077
Schistosoma mansoni amine GPCR 0.0131 0.0646 0.0646
Echinococcus granulosus neuropeptides capa receptor 0.0131 0.0646 0.0646
Schistosoma mansoni biogenic amine (5HT) receptor 0.0131 0.0646 0.0646
Echinococcus multilocularis somatostatin receptor 0.0131 0.0646 0.0646
Entamoeba histolytica hypothetical protein 0.0073 0.0256 0.0256
Loa Loa (eye worm) TYRA-2 protein 0.0131 0.0646 0.0646
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0059 0.0163 0.0163
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0131 0.0646 0.2935
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Onchocerca volvulus 0.0131 0.0646 1
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0054 0.0125 0.0125
Echinococcus multilocularis geminin 0.0169 0.0895 0.0895
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.0671 1
Mycobacterium tuberculosis Diacylglycerol kinase 0.0059 0.0163 0.016
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0828 0.0828
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.0828 0.0828
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0131 0.0646 0.2935
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0131 0.0646 0.0646
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0077 0.0075
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0131 0.0646 0.0646
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0131 0.0646 0.0646
Echinococcus granulosus allatostatin A receptor 0.0131 0.0646 0.0646
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.0621 0.0621
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0646 0.0646
Schistosoma mansoni ap endonuclease 0.0037 0.0011 0.0011
Plasmodium falciparum GAF domain-related protein, putative 0.0039 0.0025 0.0929
Echinococcus multilocularis serotonin receptor 0.0131 0.0646 0.0646
Echinococcus multilocularis neuropeptide s receptor 0.0577 0.3632 0.3632
Trypanosoma cruzi Sphingosine kinase 0.0059 0.0163 0.2426
Onchocerca volvulus 0.0131 0.0646 1
Loa Loa (eye worm) RNA binding protein 0.0128 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0059 0.0163 0.2426
Brugia malayi ORL1-like opioid receptor 0.0131 0.0646 0.2935
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Toxoplasma gondii thioredoxin reductase 0.0047 0.0077 0.1602
Echinococcus granulosus dro:myosuppressin receptor 0.0131 0.0646 0.0646
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0201 0.2996
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0186 0.0186
Brugia malayi Serotonin receptor 0.0131 0.0646 0.2935
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0011 0.0008
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.0828 0.0828
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Brugia malayi putative neuropeptide receptor 0.0131 0.0646 0.2935
Echinococcus multilocularis Diacylglycerol kinase theta 0.0059 0.0163 0.0163
Echinococcus multilocularis neuropeptide receptor 0.0131 0.0646 0.0646
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0172 0.0917 0.4167
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0121 0.0121
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0059 0.0163 0.0163
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0083 0.0322 0.2042
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0011 0.0158
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0011 0.0067
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0036 0.0003 0.0039
Trypanosoma brucei Sphingosine kinase 0.0059 0.0163 0.2426
Brugia malayi Eye-specific diacylglycerol kinase 0.0059 0.0163 0.0739
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0201 0.0913
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0482 0.3058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0646 0.0646
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0122 0.0583 0.3696
Entamoeba histolytica hypothetical protein 0.0073 0.0256 0.0256
Echinococcus granulosus sex peptide receptor 0.0131 0.0646 0.0646
Entamoeba histolytica diacylglycerol kinase, putative 0.0059 0.0163 0.0163
Brugia malayi Dopamine receptor 0.0131 0.0646 0.2935
Schistosoma mansoni neuropeptide receptor 0.0131 0.0646 0.0646
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0011 0.0008
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.0621 0.2823
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0199 0.1099 0.4995
Echinococcus multilocularis G protein coupled receptor 139 0.0131 0.0646 0.0646
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0621 0.0621
Schistosoma mansoni diacylglycerol kinase theta 0.0059 0.0163 0.0163
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0125 0.0795
Echinococcus granulosus neuropeptide receptor 0.0131 0.0646 0.0646
Onchocerca volvulus 0.0131 0.0646 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0131 0.0646 0.0646
Brugia malayi hypothetical protein 0.0131 0.0646 0.2935
Echinococcus granulosus neuropeptide Y receptor 0.0131 0.0646 0.0646
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0122 0.0583 0.3696
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Schistosoma mansoni hypothetical protein 0.0131 0.0646 0.0646
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0122 0.0583 0.0583
Echinococcus multilocularis g protein coupled receptor 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Loa Loa (eye worm) neuropeptide F receptor 0.0131 0.0646 0.0646
Loa Loa (eye worm) cytochrome P450 0.0036 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0131 0.0646 0.0646
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.0671 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0131 0.0646 0.0646
Echinococcus granulosus biogenic amine 5HT receptor 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Schistosoma mansoni biogenic amine receptor 0.0131 0.0646 0.0646
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0059 0.0163 0.0163
Brugia malayi sulfakinin receptor protein 0.0131 0.0646 0.2935
Trypanosoma brucei calpain-like protein, putative 0.0135 0.0671 1
Schistosoma mansoni biogenic amine receptor 0.0131 0.0646 0.0646
Echinococcus granulosus Diacylglycerol kinase theta 0.0059 0.0163 0.0163
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.0671 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0131 0.0646 0.2935
Leishmania major diacylglycerol kinase-like protein 0.0059 0.0163 0.2426
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0478 0.0476
Echinococcus multilocularis sphingosine kinase 1 0.1526 1 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Plasmodium vivax glutathione reductase, putative 0.0047 0.0077 0.4378
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.0163 0.2426
Echinococcus granulosus biogenic amine 5HT receptor 0.0131 0.0646 0.0646
Brugia malayi Thioredoxin reductase 0.0047 0.0077 0.0351
Schistosoma mansoni hypothetical protein 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0828 0.0828
Echinococcus granulosus alpha 1A adrenergic receptor 0.0131 0.0646 0.0646
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0121 0.0121
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0053 0.0121 0.0118
Loa Loa (eye worm) hypothetical protein 0.0172 0.0917 0.0917
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0135 0.0671 1
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0039 0.0025 0.0022
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.0671 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Onchocerca volvulus 0.0131 0.0646 1
Leishmania major hypothetical protein, conserved 0.0059 0.0163 0.2426
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0201 0.0201
Trichomonas vaginalis bmru protein, putative 0.0059 0.0163 0.1032
Echinococcus multilocularis neuropeptides capa receptor 0.0131 0.0646 0.0646
Onchocerca volvulus 0.0131 0.0646 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0025 0.0025
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.0671 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0122 0.0583 0.3696
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0131 0.0646 0.0646
Echinococcus granulosus cytochrome P450 2K1 0.0036 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Mycobacterium ulcerans glutaminase 0.027 0.1576 0.1574
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0025 0.0022
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Schistosoma mansoni histamine h1 receptor 0.0131 0.0646 0.0646
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Echinococcus multilocularis sex peptide receptor 0.0131 0.0646 0.0646
Brugia malayi RE15519p 0.0131 0.0646 0.2935
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Echinococcus multilocularis 0.0036 0.0003 0.0003

Activities

Activity type Activity value Assay description Source Reference
K (functional) = 3800 M-1 Binding to 176-mer RNA from the packaging region of HIV-1 (LAI) and value of binding constant K is determined ChEMBL. 11844684
K2 (ADMET) NI 0 min-1 Compound was tested for the pseudo first-order rate constants for the inhibition of the cleavage step (k2) of the hammerhead ribozyme at a concentration of 100 uM; no inhibition is observed at this concentration ChEMBL. No reference
K2 (ADMET) = 0.003 min-1 Compound was tested for the pseudo first-order rate constants for the inhibition of the cleavage step (k2) of the hammerhead ribozyme at a concentration of 10 uM ChEMBL. No reference
K2 (ADMET) = 0.041 min-1 Compound was tested for the pseudo first-order rate constants for the inhibition of the cleavage step (k2) of the hammerhead ribozyme at a concentration of 1 uM ChEMBL. No reference
Kd (binding) = 0.02 uM Dissociation constant of the compound with dimeric 16S rRNA RNA construct B ChEMBL. 11677142

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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