Detailed information for compound 402077

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1039.13 | Formula: C56H66N2O17
  • H donors: 4 H acceptors: 10 LogP: 4.88 Rotable bonds: 24
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](OC(=O)CCCNC(=O)OC(C)(C)C)C[C@@H]3[C@]([C@H]2[C@@H]([C@]2(C(C1=C(C)[C@@H](OC(=O)[C@@H]([C@H](c1ccccc1)NC(=O)c1ccccc1)O)C2)(C)C)O)OC(=O)c1ccccc1)(CO3)OC(=O)C
  • InChi: 1S/C56H66N2O17/c1-31-37(71-50(66)43(62)42(34-20-13-10-14-21-34)58-48(64)35-22-15-11-16-23-35)29-56(68)47(73-49(65)36-24-17-12-18-25-36)45-54(9,46(63)44(70-32(2)59)41(31)53(56,7)8)38(28-39-55(45,30-69-39)74-33(3)60)72-40(61)26-19-27-57-51(67)75-52(4,5)6/h10-18,20-25,37-39,42-45,47,62,68H,19,26-30H2,1-9H3,(H,57,67)(H,58,64)/t37-,38-,39+,42-,43+,44+,45-,47-,54+,55-,56+/m0/s1
  • InChiKey: JKSINILKSCATPJ-HTYHWGDKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine proteinase 1, putative 0.0708 0.2358 0.5375
Brugia malayi Inositol-1 0.0039 0.0056 0.0056
Giardia lamblia Cathepsin L-like protease 0.0306 0.0974 0.2588
Schistosoma mansoni hypothetical protein 0.0845 0.283 0.283
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0056 0.0129
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0477 0.0477
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0053 0.0053
Plasmodium vivax unspecified product 0.0402 0.1307 0.2978
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0028 0.0063
Loa Loa (eye worm) hypothetical protein 0.011 0.0301 0.0301
Schistosoma mansoni hypothetical protein 0.0067 0.0154 0.0154
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0046 0.0104
Plasmodium vivax serine-repeat antigen (SERA) 0.0306 0.0974 0.2221
Entamoeba histolytica hypothetical protein 0.0306 0.0974 0.2221
Trypanosoma cruzi oligopeptidase b 0.0051 0.0099 0.0099
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.04 0.04
Entamoeba histolytica cysteine protease, putative 0.0708 0.2358 0.5375
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0708 0.2358 0.5375
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0009 0.0019
Plasmodium vivax unspecified product 0.0708 0.2358 0.5375
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0128 0.0365 0.0365
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.0301 0.1126
Onchocerca volvulus 0.011 0.0301 0.014
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0133 0.0304
Schistosoma mansoni cathepsin F (C01 family) 0.1298 0.4388 0.4388
Brugia malayi beta-lactamase family protein 0.011 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.0025 0.0009 0.0009
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.0301 0.0301
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0708 0.2358 0.2358
Leishmania major cysteine peptidase A (CPA) 0.1298 0.4388 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.04 0.04
Brugia malayi beta-lactamase 0.011 0.0301 0.0301
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0306 0.0974 0.2588
Onchocerca volvulus 0.0896 0.3004 0.6661
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0306 0.0974 0.2221
Loa Loa (eye worm) hypothetical protein 0.0306 0.0974 0.0974
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1298 0.4388 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1596 0.5411 0.5411
Toxoplasma gondii thioredoxin reductase 0.0048 0.0088 0.0201
Giardia lamblia Cathepsin B precursor 0.1117 0.3766 1
Trypanosoma cruzi cysteine peptidase, putative 0.1298 0.4388 0.4388
Brugia malayi prolyl oligopeptidase family protein 0.0128 0.0365 0.0365
Entamoeba histolytica cysteine proteinase, putative 0.0708 0.2358 0.5375
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0051 0.0099 0.0099
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.0342 0.1305
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0009 0.0009
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0051 0.0099 0.0225
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0301 0.0301
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0031 0.003 0.003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1298 0.4388 1
Loa Loa (eye worm) glutathione reductase 0.0048 0.0088 0.0088
Echinococcus granulosus cathepsin L 0.0306 0.0974 0.0974
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0133 0.0133
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0056 0.0129
Giardia lamblia Hypothetical protein 0.0306 0.0974 0.2588
Mycobacterium tuberculosis Probable hydrolase 0.011 0.0301 0.1126
Plasmodium vivax serine-repeat antigen (SERA) 0.0306 0.0974 0.2221
Brugia malayi MH2 domain containing protein 0.0246 0.077 0.077
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0306 0.0974 0.2221
Loa Loa (eye worm) hypothetical protein 0.0098 0.026 0.026
Plasmodium falciparum serine repeat antigen 5 0.0306 0.0974 0.2221
Brugia malayi Papain family cysteine protease containing protein 0.0306 0.0974 0.0974
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1298 0.4388 1
Entamoeba histolytica cysteine protease, putative 0.0306 0.0974 0.2221
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0053 0.012
Loa Loa (eye worm) cathepsin B 0.1117 0.3766 0.3766
Plasmodium falciparum serine repeat antigen 4 0.0306 0.0974 0.2221
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0088 0.0199
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0053 0.012
Leishmania major oligopeptidase b 0.0051 0.0099 0.0225
Schistosoma mansoni alpha glucosidase 0.0036 0.0046 0.0046
Leishmania major hypothetical protein, conserved 0.011 0.0301 0.0686
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0056 0.0129
Plasmodium vivax vivapain-2 0.1298 0.4388 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.0301 0.1126
Trichomonas vaginalis conserved hypothetical protein 0.0306 0.0974 0.2221
Echinococcus granulosus prolyl endopeptidase 0.0128 0.0365 0.0365
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0301 0.0686
Brugia malayi cathepsin L precursor 0.0306 0.0974 0.0974
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0301 0.0686
Loa Loa (eye worm) MH2 domain-containing protein 0.0246 0.077 0.077
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.03 0.1121
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0053 0.012
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0046 0.0046
Giardia lamblia Cysteine protease 0.0306 0.0974 0.2588
Brugia malayi Papain family cysteine protease containing protein 0.0708 0.2358 0.2358
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0301 0.0301
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0306 0.0974 0.2221
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.04 0.04
Toxoplasma gondii exonuclease III APE 0.0038 0.0053 0.012
Brugia malayi hypothetical protein 0.0025 0.0009 0.0009
Entamoeba histolytica cysteine protease, putative 0.0708 0.2358 0.5375
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0306 0.0974 0.2221
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0306 0.0974 0.2221
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0009 0.0019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1298 0.4388 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.0477 0.0477
Plasmodium falciparum serine repeat antigen 1 0.0306 0.0974 0.2221
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1298 0.4388 0.4388
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1298 0.4388 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1298 0.4388 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1117 0.3766 0.3766
Brugia malayi beta-lactamase family protein 0.011 0.0301 0.0301
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.293 1 1
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0088 0.0201
Trypanosoma brucei oligopeptidase b 0.0051 0.0099 0.0225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0306 0.0974 0.2221
Trypanosoma cruzi major cysteine proteinase, putative 0.0306 0.0974 0.0974
Plasmodium vivax vivapain-3 0.0708 0.2358 0.5375
Giardia lamblia Cysteine protease 0.0306 0.0974 0.2588
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0009 0.0009
Trichomonas vaginalis esterase, putative 0.011 0.0301 0.0686
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0088 0.0088
Brugia malayi Papain family cysteine protease containing protein 0.0708 0.2358 0.2358
Onchocerca volvulus 0.011 0.0301 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1117 0.3766 0.8582
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0053 0.012
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0046 0.0104
Brugia malayi POT family protein 0.0043 0.007 0.007
Plasmodium falciparum serine repeat antigen 6 0.0306 0.0974 0.2221
Entamoeba histolytica cysteine protease, putative 0.0708 0.2358 0.5375
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0896 0.3004 0.6846
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0046 0.0104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1298 0.4388 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0009 0.0019
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0046 0.0046
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.04 0.04
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1298 0.4388 1
Schistosoma mansoni cathepsin C 0.0306 0.0974 0.0974
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0402 0.1307 0.1307
Trypanosoma cruzi major cysteine proteinase, putative 0.0306 0.0974 0.0974
Giardia lamblia Cathepsin B precursor 0.1117 0.3766 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0306 0.0974 0.2221
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.003 0.003
Entamoeba histolytica cysteine protease, putative 0.0306 0.0974 0.2221
Brugia malayi glutathione reductase 0.0048 0.0088 0.0088
Mycobacterium ulcerans hypothetical protein 0.011 0.0301 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1117 0.3766 0.3766
Loa Loa (eye worm) hypothetical protein 0.011 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.0402 0.1307 0.1307
Giardia lamblia Cathepsin L precursor 0.0306 0.0974 0.2588
Trypanosoma cruzi cysteine protease, putative 0.0708 0.2358 0.2358
Brugia malayi Papain family cysteine protease containing protein 0.0306 0.0974 0.0974
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0056 0.0056
Leishmania major cathepsin L-like protease 0.1298 0.4388 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0008 0.0018
Brugia malayi cathepsin F-like cysteine proteinase 0.0306 0.0974 0.0974
Trypanosoma cruzi cysteine peptidase, putative 0.0402 0.1307 0.1307
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0115 0.0318 0.1201
Giardia lamblia Hypothetical protein 0.0306 0.0974 0.2588
Schistosoma mansoni ap endonuclease 0.0038 0.0053 0.0053
Brugia malayi Cathepsin L-like precursor 0.1298 0.4388 0.4388
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0306 0.0974 0.0974
Loa Loa (eye worm) hypothetical protein 0.0031 0.003 0.003
Entamoeba histolytica cysteine proteinase 2 0.0708 0.2358 0.5375
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0046 0.0104
Trypanosoma brucei cysteine peptidase C (CPC) 0.1117 0.3766 0.8582
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0053 0.012
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0306 0.0974 0.0974
Toxoplasma gondii cathepsin CPC2 0.0306 0.0974 0.2221
Loa Loa (eye worm) hypothetical protein 0.0306 0.0974 0.0974
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.0342 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0325 0.1042 0.1042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0708 0.2358 0.5375
Toxoplasma gondii prolyl endopeptidase 0.0128 0.0365 0.0831
Giardia lamblia Cysteine protease 0.0306 0.0974 0.2588
Brugia malayi Cathepsin L-like precursor 0.0402 0.1307 0.1307
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0067 0.0154 0.0154
Echinococcus multilocularis cathepsin b 0.293 1 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0306 0.0974 0.0974
Trypanosoma cruzi prolyl endopeptidase 0.0128 0.0365 0.0365
Entamoeba histolytica cysteine protease, putative 0.0708 0.2358 0.5375
Plasmodium vivax vivapain-1 0.0708 0.2358 0.5375
Giardia lamblia Encystation-specific protease 0.0306 0.0974 0.2588
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.293 1 1
Echinococcus multilocularis prolyl endopeptidase 0.0128 0.0365 0.0365
Brugia malayi Cathepsin L-like precursor 0.0896 0.3004 0.3004
Schistosoma mansoni cathepsin B (C01 family) 0.0306 0.0974 0.0974
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.0301 0.1126
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1298 0.4388 0.4388
Entamoeba histolytica cysteine protease, putative 0.0708 0.2358 0.5375
Schistosoma mansoni alpha-glucosidase 0.0139 0.0399 0.0399
Onchocerca volvulus Cathepsin F homolog 0.1298 0.4388 1
Plasmodium vivax hypothetical protein, conserved 0.011 0.0301 0.0686
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0306 0.0974 0.2221
Echinococcus granulosus cathepsin b 0.293 1 1
Loa Loa (eye worm) hypothetical protein 0.011 0.0301 0.0301
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0133 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1298 0.4388 1
Echinococcus granulosus cathepsin L 0.0708 0.2358 0.2358
Leishmania major trypanothione reductase 0.0048 0.0088 0.0201
Onchocerca volvulus Prolyl endopeptidase homolog 0.0128 0.0365 0.0293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0306 0.0974 0.2221
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0301 0.0686
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1298 0.4388 1
Schistosoma mansoni inositol monophosphatase 0.0039 0.0056 0.0056
Mycobacterium tuberculosis Conserved protein 0.011 0.0301 0.1126
Echinococcus multilocularis cysteine protease 0.1298 0.4388 0.4388
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0306 0.0974 0.2221
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.0301 0.0301
Giardia lamblia Cathepsin B precursor 0.0306 0.0974 0.2588
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0306 0.0974 0.2221
Brugia malayi Cathepsin L-like precursor 0.1298 0.4388 0.4388
Echinococcus granulosus snurportin 1 0.0325 0.1042 0.1042
Loa Loa (eye worm) fibroinase 0.1298 0.4388 0.4388
Echinococcus granulosus cathepsin l cysteine peptidase 0.1298 0.4388 0.4388
Onchocerca volvulus 0.1298 0.4388 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1298 0.4388 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1298 0.4388 1
Schistosoma mansoni ap endonuclease 0.0038 0.0053 0.0053
Mycobacterium leprae Probable lipase LipE 0.011 0.0301 0.8632
Loa Loa (eye worm) hypothetical protein 0.0896 0.3004 0.3004
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0306 0.0974 0.2221
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0009 0.0019
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0301 0.0686
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0306 0.0974 0.2221
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.0974 0.0974
Schistosoma mansoni hypothetical protein 0.0031 0.003 0.003
Echinococcus multilocularis cysteine protease 0.1298 0.4388 0.4388
Schistosoma mansoni cathepsin S (C01 family) 0.0306 0.0974 0.0974
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.03 0.1121
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.0301 0.1126
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0306 0.0974 0.2221
Schistosoma mansoni hypothetical protein 0.0845 0.283 0.283
Loa Loa (eye worm) hypothetical protein 0.0896 0.3004 0.3004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0133 0.3254
Giardia lamblia Cathepsin B precursor 0.0306 0.0974 0.2588
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1298 0.4388 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1298 0.4388 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0053 0.0044
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.003 0.003
Giardia lamblia Cathepsin B precursor 0.1117 0.3766 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0088 0.0088
Entamoeba histolytica cysteine protease, putative 0.0708 0.2358 0.5375
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1298 0.4388 1
Loa Loa (eye worm) hypothetical protein 0.0306 0.0974 0.0974
Giardia lamblia Cathepsin L precursor 0.0306 0.0974 0.2588
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0306 0.0974 0.0974
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.03 0.8596
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0046 0.0104
Plasmodium falciparum cysteine proteinase falcipain 1 0.0708 0.2358 0.5375
Loa Loa (eye worm) hypothetical protein 0.0306 0.0974 0.0974
Trypanosoma brucei prolyl endopeptidase 0.0128 0.0365 0.0831
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0306 0.0974 0.2221
Entamoeba histolytica cysteine protease, putative 0.0708 0.2358 0.5375
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.293 1 1
Giardia lamblia Cathepsin L precursor 0.0306 0.0974 0.2588
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0306 0.0974 0.2221
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0128 0.0365 0.0365
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.293 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.003 0.003
Entamoeba histolytica cysteine protease, putative 0.0306 0.0974 0.2221
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0051 0.0099 0.1851
Trypanosoma cruzi cysteine proteinase, putative 0.0708 0.2358 0.2358
Leishmania major cathepsin L-like protease 0.1298 0.4388 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.0342 0.1305
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0053 0.0053
Plasmodium falciparum serine repeat antigen 8 0.0306 0.0974 0.2221
Entamoeba histolytica cysteine protease, putative 0.0708 0.2358 0.5375
Leishmania major cathepsin L-like protease 0.1298 0.4388 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0046 0.0046
Echinococcus granulosus cathepsin l1 0.0896 0.3004 0.3004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1298 0.4388 1
Onchocerca volvulus 0.011 0.0301 0.014
Brugia malayi cathepsin L-like precursor 0.0896 0.3004 0.3004
Echinococcus granulosus cathepsin l1 0.1298 0.4388 0.4388
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.0301 0.1126
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0051 0.0099 0.0244
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0046 0.0104
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0051 0.0099 0.0225
Loa Loa (eye worm) hypothetical protein 0.0402 0.1307 0.1307
Schistosoma mansoni hypothetical protein 0.0325 0.1042 0.1042
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0053 0.0053
Brugia malayi cathepsin Z-like cysteine proteinase 0.0306 0.0974 0.0974
Loa Loa (eye worm) hypothetical protein 0.0896 0.3004 0.3004
Loa Loa (eye worm) ctsf protein 0.1298 0.4388 0.4388
Trichomonas vaginalis conserved hypothetical protein 0.0306 0.0974 0.2221
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0133 0.0133
Entamoeba histolytica cysteine protease, putative 0.0708 0.2358 0.5375
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.0301 0.1126
Plasmodium falciparum serine repeat antigen 9 0.0306 0.0974 0.2221
Mycobacterium leprae conserved hypothetical protein 0.011 0.0301 0.8632
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.026 0.026
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.03 0.1121
Trypanosoma brucei trypanothione reductase 0.0048 0.0088 0.0201
Loa Loa (eye worm) hypothetical protein 0.011 0.0301 0.0301
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0306 0.0974 0.2221
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0708 0.2358 0.2358
Leishmania major cathepsin L-like protease 0.1298 0.4388 1
Mycobacterium ulcerans beta-lactamase 0.011 0.0301 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.026 0.026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1298 0.4388 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.026 0.026
Entamoeba histolytica cysteine proteinase, putative 0.1298 0.4388 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.03 0.1121
Echinococcus granulosus cathepsin b 0.293 1 1
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0128 0.0365 0.0831
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.003 0.003
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.0301 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.04 0.04
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0028 0.0063
Schistosoma mansoni importin beta-1 0.003 0.0028 0.0028
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0306 0.0974 0.2588
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0306 0.0974 0.2221
Plasmodium vivax importin-beta 2, putative 0.003 0.0028 0.0063
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0009 0.0019
Plasmodium falciparum serine repeat antigen 2 0.0306 0.0974 0.2221
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0306 0.0974 0.2221
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0053 0.012
Brugia malayi Papain family cysteine protease containing protein 0.0306 0.0974 0.0974
Toxoplasma gondii cathepsin B 0.1117 0.3766 0.8582
Plasmodium falciparum serine repeat antigen 7 0.0306 0.0974 0.2221
Mycobacterium tuberculosis Probable reductase 0.011 0.03 0.1121
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0306 0.0974 0.2221
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0133 0.0396
Onchocerca volvulus 0.1298 0.4388 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0133 0.3254
Trypanosoma cruzi cysteine peptidase, putative 0.1298 0.4388 0.4388
Echinococcus granulosus cathepsin L cysteine protease 0.0708 0.2358 0.2358
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.04 0.04
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.0301 0.0301
Echinococcus multilocularis geminin 0.0845 0.283 0.283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0306 0.0974 0.2221
Entamoeba histolytica cysteine proteinase, putative 0.0708 0.2358 0.5375
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.0301 0.0301
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1298 0.4388 0.4388
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0306 0.0974 0.2221
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0154 0.0154
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0306 0.0974 0.2221
Schistosoma mansoni inositol monophosphatase 0.0039 0.0056 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0896 0.3004 0.6846
Leishmania major cathepsin L-like protease 0.1298 0.4388 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1298 0.4388 1
Plasmodium vivax unspecified product 0.0306 0.0974 0.2221
Brugia malayi RNA, U transporter 1 0.0087 0.0221 0.0221
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0056 0.0129
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1298 0.4388 1
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0051 0.0099 0.0099
Echinococcus multilocularis cathepsin L cysteine protease 0.1298 0.4388 0.4388
Brugia malayi Cathepsin L-like precursor 0.1298 0.4388 0.4388
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0046 0.0104
Loa Loa (eye worm) hypothetical protein 0.011 0.0301 0.0301
Trypanosoma brucei hypothetical protein, conserved 0.011 0.0301 0.0686
Giardia lamblia Cathepsin L precursor 0.0306 0.0974 0.2588
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0056 0.0056
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0053 0.012
Mycobacterium tuberculosis Conserved protein 0.011 0.0301 0.1126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1298 0.4388 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0306 0.0974 0.2221
Giardia lamblia Cathepsin B precursor 0.0306 0.0974 0.2588
Entamoeba histolytica cysteine proteinase, putative 0.0896 0.3004 0.6846
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0402 0.1307 0.1307
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0896 0.3004 0.3004
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0306 0.0974 0.2221
Trypanosoma cruzi cysteine peptidase, putative 0.1298 0.4388 0.4388
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0056 0.0056
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.04 0.04
Leishmania major cathepsin L-like protease 0.1298 0.4388 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0306 0.0974 0.2221
Entamoeba histolytica cysteine proteinase, putative 0.0708 0.2358 0.5375
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0051 0.0099 0.1872
Echinococcus multilocularis cathepsin b 0.293 1 1
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0008 0.0018
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0477 0.0477
Plasmodium falciparum glutathione reductase 0.0048 0.0088 0.0201
Giardia lamblia Cathepsin L precursor 0.0306 0.0974 0.2588
Brugia malayi Cathepsin L-like precursor 0.1298 0.4388 0.4388
Brugia malayi Cathepsin L-like precursor 0.1298 0.4388 0.4388
Schistosoma mansoni cathepsin F (C01 family) 0.0896 0.3004 0.3004
Giardia lamblia Cathepsin L precursor 0.0306 0.0974 0.2588
Trypanosoma cruzi cysteine proteinase, putative 0.0708 0.2358 0.2358
Plasmodium falciparum importin beta, putative 0.003 0.0028 0.0063
Plasmodium falciparum thioredoxin reductase 0.0048 0.0088 0.0201
Entamoeba histolytica cysteine protease, putative 0.0708 0.2358 0.5375
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0053 0.014
Loa Loa (eye worm) transcription factor SMAD2 0.0246 0.077 0.077
Trypanosoma cruzi cysteine peptidase, putative 0.1298 0.4388 0.4388
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0306 0.0974 0.0974
Loa Loa (eye worm) hypothetical protein 0.0306 0.0974 0.0974
Plasmodium vivax vivapain-2 0.1298 0.4388 1
Brugia malayi Thioredoxin reductase 0.0048 0.0088 0.0088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1298 0.4388 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.0477 0.0477
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0046 0.0104
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.04 0.04
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0056 0.0158
Schistosoma mansoni cathepsin F (C01 family) 0.1298 0.4388 0.4388
Trypanosoma cruzi cruzipain precursor, putative 0.0402 0.1307 0.1307
Schistosoma mansoni hypothetical protein 0.0031 0.003 0.003
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0708 0.2358 0.2358
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0301 0.0301
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0056 0.0129
Plasmodium falciparum cysteine proteinase falcipain 3 0.1298 0.4388 1
Schistosoma mansoni alpha-glucosidase 0.0139 0.0399 0.0399
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0306 0.0974 0.0974
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1298 0.4388 0.4388
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0306 0.0974 0.2221
Plasmodium falciparum serine repeat antigen 3 0.0306 0.0974 0.2221
Loa Loa (eye worm) cysteine protease 0.1298 0.4388 0.4388
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1298 0.4388 1
Onchocerca volvulus Cathepsin L homolog 0.1298 0.4388 1
Entamoeba histolytica cysteine protease, putative 0.0306 0.0974 0.2221
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1298 0.4388 1
Brugia malayi Latrophilin receptor protein 2 0.0031 0.003 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1298 0.4388 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0088 0.0088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1298 0.4388 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0306 0.0974 0.2221
Onchocerca volvulus 0.1298 0.4388 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0708 0.2358 0.5375
Onchocerca volvulus 0.1298 0.4388 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1298 0.4388 1
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0046 0.0104
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0306 0.0974 0.2221
Toxoplasma gondii cathepsin CPC1 0.0306 0.0974 0.2221
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1298 0.4388 1
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0133 0.0304
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.003 0.003
Plasmodium vivax glutathione reductase, putative 0.0048 0.0088 0.0201
Loa Loa (eye worm) hypothetical protein 0.293 1 1
Brugia malayi Cathepsin L-like precursor 0.0896 0.3004 0.3004
Echinococcus multilocularis cathepsin L cysteine protease 0.1298 0.4388 0.4388
Mycobacterium tuberculosis Conserved protein 0.011 0.0301 0.1126
Schistosoma mansoni hypothetical protein 0.0031 0.003 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1298 0.4388 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0306 0.0974 0.0974
Entamoeba histolytica cysteine protease, putative 0.0708 0.2358 0.5375
Echinococcus granulosus GPCR family 2 0.0031 0.003 0.003
Toxoplasma gondii cathepsin CPL 0.1298 0.4388 1
Entamoeba histolytica cysteine protease, putative 0.0306 0.0974 0.2221
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.0301 1
Echinococcus multilocularis importin subunit beta 1 0.003 0.0028 0.0028
Trypanosoma brucei glucosidase, putative 0.0036 0.0046 0.0104
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0008 0.0018
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.293 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1298 0.4388 1
Entamoeba histolytica cysteine proteinase, putative 0.0708 0.2358 0.5375
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.0974 0.0974
Brugia malayi cathepsin L-like cysteine proteinase 0.0306 0.0974 0.0974
Echinococcus multilocularis cathepsin L 0.0708 0.2358 0.2358
Leishmania major cathepsin L-like protease 0.1298 0.4388 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0028 0.0028
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0703 0.234 1
Echinococcus multilocularis GPCR, family 2 0.0031 0.003 0.003
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0306 0.0974 0.2588
Leishmania major cathepsin L-like protease 0.1298 0.4388 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.003 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0306 0.0974 0.2221
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1298 0.4388 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.04 0.04
Loa Loa (eye worm) POT family protein 0.0043 0.007 0.007
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0088 0.0088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1298 0.4388 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0056 0.0129
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.0342 0.1305
Loa Loa (eye worm) hypothetical protein 0.1298 0.4388 0.4388
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0306 0.0974 0.2221
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1298 0.4388 1
Onchocerca volvulus Cathepsin L homolog 0.1298 0.4388 1
Entamoeba histolytica hypothetical protein 0.0025 0.0008 0.0018
Trypanosoma cruzi cysteine peptidase, putative 0.0708 0.2358 0.2358
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.0974 0.0974
Entamoeba histolytica cysteine protease, putative 0.0708 0.2358 0.5375
Echinococcus multilocularis snurportin 1 0.0325 0.1042 0.1042
Trypanosoma brucei prolyl oligopeptidase, putative 0.0051 0.0099 0.0225
Giardia lamblia Cathepsin L-like protease 0.0306 0.0974 0.2588
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0306 0.0974 0.2221
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1298 0.4388 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1298 0.4388 1
Brugia malayi Cathepsin L-like precursor 0.1298 0.4388 0.4388
Leishmania major hypothetical protein, conserved 0.0025 0.0009 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1298 0.4388 1
Onchocerca volvulus 0.0306 0.0974 0.1765
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1298 0.4388 1
Brugia malayi fibroinase precursor 0.0306 0.0974 0.0974
Echinococcus multilocularis cathepsin L 0.0306 0.0974 0.0974
Onchocerca volvulus 0.1298 0.4388 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0306 0.0974 0.2588
Entamoeba histolytica cysteine protease, putative 0.0306 0.0974 0.2221
Entamoeba histolytica cysteine proteinase, putative 0.1298 0.4388 1
Loa Loa (eye worm) beta-lactamase 0.011 0.0301 0.0301
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.03 0.1121
Giardia lamblia Cathepsin B precursor 0.0306 0.0974 0.2588
Brugia malayi Cathepsin L-like cysteine proteinase 0.0896 0.3004 0.3004
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.0974 0.0974
Mycobacterium tuberculosis Probable peptidase 0.0051 0.0099 0.0244
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.0974 0.0974
Brugia malayi Papain family cysteine protease containing protein 0.1298 0.4388 0.4388
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0402 0.1307 0.1307
Loa Loa (eye worm) inositol-1 0.0039 0.0056 0.0056
Giardia lamblia Cysteine protease 0.0306 0.0974 0.2588
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0028 0.0063
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1117 0.3766 0.8582
Trypanosoma cruzi cruzipain precursor, putative 0.1298 0.4388 0.4388
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0301 0.0686
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0306 0.0974 0.2221
Brugia malayi cathepsin Z-like cysteine proteinase 0.0306 0.0974 0.0974
Echinococcus granulosus importin subunit beta 1 0.003 0.0028 0.0028
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0046 0.0104
Schistosoma mansoni cathepsin s 0.0402 0.1307 0.1307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1298 0.4388 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0046 0.0104
Echinococcus granulosus cathepsin L cysteine proteinase 0.1298 0.4388 0.4388
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.011 0.0301 0.0301
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0708 0.2358 0.5375
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0046 0.0104
Loa Loa (eye worm) hypothetical protein 0.0128 0.0365 0.0365
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0056 0.0129
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0133 0.0133
Onchocerca volvulus Cathepsin L homolog 0.0306 0.0974 0.1765
Entamoeba histolytica cysteine protease, putative 0.0708 0.2358 0.5375
Echinococcus granulosus geminin 0.0845 0.283 0.283
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0708 0.2358 0.2358
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0053 0.0053
Mycobacterium ulcerans lipase LipD 0.011 0.0301 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0306 0.0974 0.0974
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0046 0.0104
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0056 1
Onchocerca volvulus 0.1298 0.4388 1
Entamoeba histolytica cysteine protease, putative 0.1298 0.4388 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0301 0.0301
Brugia malayi cathepsin F-like cysteine proteinase 0.0402 0.1307 0.1307
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0053 0.0053
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.0477 0.0477
Giardia lamblia Cathepsin B precursor 0.0306 0.0974 0.2588
Leishmania major importin beta-1 subunit, putative 0.0025 0.0008 0.0018
Brugia malayi Importin beta-1 subunit 0.003 0.0028 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1298 0.4388 1
Trypanosoma cruzi oligopeptidase b 0.0051 0.0099 0.0099
Onchocerca volvulus 0.1298 0.4388 1
Toxoplasma gondii ABC1 family protein 0.011 0.0301 0.0686
Loa Loa (eye worm) hypothetical protein 0.0306 0.0974 0.0974
Echinococcus granulosus cysteine protease 0.0708 0.2358 0.2358
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0053 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0133 0.3254

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) > 80 nM Cytotoxicity activity of the compound was measured against human breast cancer cell line MCF-7; Did not inhibit proliferation at maximum concentration tested ChEMBL. 9873699
ED50 (functional) > 80 nM Cytotoxicity activity of the compound was measured against human breast cancer cell line MCF-7; Did not inhibit proliferation at maximum concentration tested ChEMBL. 9873699
ED50 (functional) > 5000 nM Cytotoxicity activity of the compound was measured against resistant human breast cancer cell line MCF-7; Did not inhibit proliferation at maximum concentration tested ChEMBL. 9873699
ED50 (functional) > 5000 nM Cytotoxicity activity of the compound was measured against resistant human breast cancer cell line MCF-7; Did not inhibit proliferation at maximum concentration tested ChEMBL. 9873699
Ratio (functional) = 0.7 Effect on microtubule assembly in MCF-7 cells, compared to paclitaxel (0.3uM), given as ratio of respective ED50 ChEMBL. 9873699

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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