Detailed information for compound 409391

Basic information

Technical information
  • TDR Targets ID: 409391
  • Name: 2-heptyl-3,4-dihydro-1H-isoquinoline-6,7-diol
  • MW: 263.375 | Formula: C16H25NO2
  • H donors: 2 H acceptors: 2 LogP: 3.96 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCN1CCc2c(C1)cc(c(c2)O)O
  • InChi: 1S/C16H25NO2/c1-2-3-4-5-6-8-17-9-7-13-10-15(18)16(19)11-14(13)12-17/h10-11,18-19H,2-9,12H2,1H3
  • InChiKey: NPOMEWIFJUKGMV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6,7-Isoquinolinediol, 2-heptyl-1,2,3,4-tetrahydro-
  • AIDS-418162
  • AIDS418162

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine proteinase, putative 0.0156 0.0502 1
Schistosoma mansoni cathepsin D (A01 family) 0.0524 0.1991 0.1991
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0051 0.0051
Brugia malayi Sodium:solute symporter family protein 0.0638 0.2454 0.3168
Brugia malayi Cathepsin L-like precursor 0.0052 0.0078 0.0101
Schistosoma mansoni inositol transporter 0.25 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0156 0.0502 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0127 0.0165
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0073 0.0073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0053 0.0084 0.0108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Schistosoma mansoni cathepsin F (C01 family) 0.0156 0.0502 0.0502
Leishmania major cathepsin L-like protease 0.0156 0.0502 0.0621
Trypanosoma cruzi cysteine peptidase, putative 0.0156 0.0502 0.0621
Toxoplasma gondii aspartyl protease ASP3 0.0124 0.0372 0.0454
Trypanosoma cruzi cysteine peptidase, putative 0.0156 0.0502 0.0621
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0156 0.0502 0.0502
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0073 0.0094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0156 0.0502 0.0648
Schistosoma mansoni high-affinity choline transporter 0.0638 0.2454 0.2454
Schistosoma mansoni fructose-16-bisphosphatase-related 0.1944 0.7746 0.7746
Echinococcus granulosus sodium:glucose cotransporter 2 0.25 1 1
Brugia malayi aspartic protease BmAsp-2, identical 0.0045 0.0051 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Brugia malayi fructose-1,6-bisphosphatase 0.1944 0.7746 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0051 0.0051
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.0279 0.0279
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0195 0.0224
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0073 0.0073
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0043 0.0043
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0502 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0152 0.0196
Trypanosoma cruzi cysteine proteinase, putative 0.008 0.0195 0.0224
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0156 0.0502 1
Schistosoma mansoni inositol transporter 0.25 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Onchocerca volvulus Cathepsin F homolog 0.0156 0.0502 0.1875
Plasmodium falciparum plasmepsin II 0.0154 0.0492 0.9793
Leishmania major cathepsin L-like protease 0.0156 0.0502 0.0621
Echinococcus granulosus cathepsin l1 0.0156 0.0502 0.0502
Brugia malayi cathepsin L-like precursor 0.0104 0.0293 0.0378
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0156 0.0502 1
Echinococcus granulosus fructose 16 bisphosphatase 1 0.1944 0.7746 0.7746
Brugia malayi Cathepsin L-like precursor 0.0156 0.0502 0.0648
Trypanosoma cruzi cysteine proteinase, putative 0.008 0.0195 0.0224
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0502 1
Schistosoma mansoni cathepsin F (C01 family) 0.0156 0.0502 0.0502
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0021 0.0021
Toxoplasma gondii aspartyl protease ASP1 0.0154 0.0492 0.0609
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.1944 0.7746 1
Leishmania major cathepsin L-like protease 0.0156 0.0502 0.0621
Brugia malayi Augmenter of liver regeneration 0.0038 0.0022 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Toxoplasma gondii aspartyl protease 0.0045 0.0051 0.0038
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0502 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0502 1
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0154 0.0492 0.0635
Onchocerca volvulus 0.0156 0.0502 0.1875
Schistosoma mansoni memapsin-2 (A01 family) 0.0045 0.0051 0.0051
Echinococcus granulosus cysteine protease 0.008 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0052 0.0078 0.0101
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0723 0.2798 0.3595
Brugia malayi jmjC domain containing protein 0.0101 0.0279 0.036
Echinococcus granulosus cathepsin L cysteine proteinase 0.0156 0.0502 0.0502
Leishmania major cathepsin L-like protease 0.0156 0.0502 0.0621
Brugia malayi MH2 domain containing protein 0.0118 0.0347 0.0448
Loa Loa (eye worm) hypothetical protein 0.0052 0.0078 0.0101
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0051 0.0051
Brugia malayi Eukaryotic aspartyl protease family protein 0.0045 0.0051 0.0066
Loa Loa (eye worm) hypothetical protein 0.0097 0.0261 0.0337
Loa Loa (eye worm) aspartyl protease 6 0.0045 0.0051 0.0066
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0104 0.0293 0.0351
Plasmodium falciparum plasmepsin VIII, putative 0.0045 0.0051 0.0611
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0195 0.0224
Echinococcus multilocularis cathepsin L cysteine protease 0.0156 0.0502 0.0502
Brugia malayi Papain family cysteine protease containing protein 0.008 0.0195 0.0252
Plasmodium falciparum plasmepsin V 0.0045 0.0051 0.0611
Loa Loa (eye worm) hypothetical protein 0.0052 0.0078 0.0101
Loa Loa (eye worm) hypothetical protein 0.0156 0.0502 0.0648
Plasmodium vivax unspecified product 0.008 0.0195 0.361
Brugia malayi Papain family cysteine protease containing protein 0.008 0.0195 0.0252
Brugia malayi Cathepsin L-like precursor 0.0156 0.0502 0.0648
Loa Loa (eye worm) hypothetical protein 0.0154 0.0492 0.0635
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0723 0.2798 0.3595
Trypanosoma cruzi cysteine peptidase, putative 0.0156 0.0502 0.0621
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Trypanosoma brucei fructose-1,6-bisphosphatase 0.1944 0.7746 1
Toxoplasma gondii fructose-bisphospatase II 0.1944 0.7746 1
Onchocerca volvulus 0.0156 0.0502 0.1875
Leishmania major cathepsin L-like protease 0.0156 0.0502 0.0621
Schistosoma mansoni hypothetical protein 0.007 0.0152 0.0152
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Brugia malayi hypothetical protein 0.0097 0.0261 0.0337
Loa Loa (eye worm) hypothetical protein 0.0102 0.0283 0.0365
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0502 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0021 0.0021
Plasmodium falciparum plasmepsin I 0.0154 0.0492 0.9793
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0638 0.2454 0.2454
Leishmania major cysteine peptidase A (CPA) 0.0156 0.0502 0.0621
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0156 0.0502 0.0502
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0051 0.0051
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0152 0.0196
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0154 0.0492 0.9675
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0051 0.0051
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0043 0.0043
Plasmodium vivax aspartyl protease, putative 0.0045 0.0051 0.0611
Plasmodium falciparum plasmepsin IX 0.0124 0.0372 0.7304
Echinococcus multilocularis cathepsin L 0.008 0.0195 0.0195
Plasmodium falciparum cysteine proteinase falcipain 1 0.008 0.0195 0.361
Onchocerca volvulus Cathepsin L homolog 0.0156 0.0502 0.1875
Plasmodium falciparum plasmepsin VI 0.0154 0.0492 0.9793
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0073 0.0094
Brugia malayi Cathepsin L-like precursor 0.0104 0.0293 0.0378
Echinococcus granulosus solute carrier family 5 0.25 1 1
Toxoplasma gondii cathepsin CPL 0.0156 0.0502 0.0621
Plasmodium vivax unspecified product 0.0052 0.0078 0.1177
Loa Loa (eye worm) cysteine protease 0.0156 0.0502 0.0648
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0073 0.0073
Onchocerca volvulus 0.0156 0.0502 0.1875
Echinococcus multilocularis sodium:myo inositol cotransporter 0.25 1 1
Brugia malayi Cathepsin L-like precursor 0.0156 0.0502 0.0648
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0154 0.0492 0.0492
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0638 0.2454 0.2454
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0073 0.0073
Brugia malayi Cathepsin L-like precursor 0.0156 0.0502 0.0648
Echinococcus granulosus cathepsin L 0.008 0.0195 0.0195
Trypanosoma cruzi cruzipain precursor, putative 0.0156 0.0502 0.0621
Trypanosoma cruzi cysteine peptidase, putative 0.008 0.0195 0.0224
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0045 0.0051 0.0066
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0045 0.0051 0.0038
Trypanosoma cruzi cruzipain precursor, putative 0.0052 0.0078 0.0073
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.1944 0.7746 0.7746
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0154 0.0492 0.0609
Loa Loa (eye worm) hypothetical protein 0.0104 0.0293 0.0378
Schistosoma mansoni cathepsin F (C01 family) 0.0104 0.0293 0.0293
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0051 0.0051
Echinococcus multilocularis high affinity choline transporter 1 0.0638 0.2454 0.2454
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0021 0.0021
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0038 0.0022 0.0022
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0156 0.0502 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0261 0.0337
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Echinococcus granulosus sodium:myo inositol cotransporter 0.25 1 1
Echinococcus granulosus cathepsin L cysteine protease 0.008 0.0195 0.0195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0104 0.0293 0.3182
Echinococcus multilocularis cathepsin L cysteine protease 0.0156 0.0502 0.0502
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Schistosoma mansoni jumonji domain containing protein 0.008 0.0195 0.0195
Brugia malayi GH02984p 0.0638 0.2454 0.3168
Loa Loa (eye worm) hypothetical protein 0.0104 0.0293 0.0378
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.0283 0.0365
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.0283 0.0365
Brugia malayi Cathepsin L-like cysteine proteinase 0.0104 0.0293 0.0378
Entamoeba histolytica cysteine protease, putative 0.0156 0.0502 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0502 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0154 0.0492 0.0492
Plasmodium falciparum plasmepsin III 0.0045 0.0051 0.0611
Onchocerca volvulus Cathepsin L homolog 0.0156 0.0502 0.1875
Onchocerca volvulus 0.0156 0.0502 0.1875
Plasmodium vivax vivapain-2 0.0156 0.0502 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.008 0.0195 0.0195
Echinococcus multilocularis cysteine protease 0.0156 0.0502 0.0502
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Leishmania major cathepsin L-like protease 0.0156 0.0502 0.0621
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0051 0.0051
Schistosoma mansoni eyes absent homolog 0.0097 0.0261 0.0261
Loa Loa (eye worm) hypothetical protein 0.0045 0.0051 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Plasmodium falciparum plasmepsin X 0.0124 0.0372 0.7304
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0502 1
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.1944 0.7746 1
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0638 0.2454 0.3149
Brugia malayi Cathepsin L-like precursor 0.0156 0.0502 0.0648
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0502 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0051 0.0051
Loa Loa (eye worm) fibroinase 0.0156 0.0502 0.0648
Schistosoma mansoni cathepsin D (A01 family) 0.0524 0.1991 0.1991
Leishmania major cathepsin L-like protease 0.0156 0.0502 0.0621
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0502 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Onchocerca volvulus 0.0156 0.0502 0.1875
Toxoplasma gondii fructose-bisphospatase I 0.0723 0.2798 0.3595
Onchocerca volvulus 0.0156 0.0502 0.1875
Brugia malayi jmjC domain containing protein 0.0037 0.0021 0.0027
Plasmodium falciparum cysteine proteinase falcipain 3 0.0156 0.0502 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0051 0.0066
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.0283 0.0365
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.008 0.0195 0.0224
Leishmania major cathepsin L-like protease 0.0156 0.0502 0.0621
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0021 0.0027
Brugia malayi Cathepsin L-like precursor 0.0104 0.0293 0.0378
Brugia malayi hypothetical protein 0.0045 0.0051 0.0066
Trypanosoma cruzi cysteine protease, putative 0.008 0.0195 0.0224
Plasmodium vivax vivapain-3 0.008 0.0195 0.361
Plasmodium vivax vivapain-1 0.008 0.0195 0.361
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0104 0.0293 0.3182
Plasmodium vivax aspartyl proteinase, putative 0.0045 0.0051 0.0611
Plasmodium falciparum plasmepsin VII 0.0045 0.0051 0.0611
Loa Loa (eye worm) hypothetical protein 0.0638 0.2454 0.3168
Brugia malayi Pepsin A precursor 0.0045 0.0051 0.0066
Loa Loa (eye worm) hypothetical protein 0.0638 0.2454 0.3168
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0156 0.0502 1
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0347 0.0448
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0154 0.0492 0.0492
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0156 0.0502 0.0502
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.1944 0.7746 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0293 0.0378
Brugia malayi cathepsin F-like cysteine proteinase 0.0052 0.0078 0.0101
Brugia malayi hypothetical protein 0.0045 0.0051 0.0066
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0021 0.0021
Brugia malayi aspartic protease BmAsp-1, identical 0.0045 0.0051 0.0066
Plasmodium vivax aspartyl protease, putative 0.0124 0.0372 0.7304
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.008 0.0195 0.0195
Schistosoma mansoni cathepsin s 0.0052 0.0078 0.0078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0078 0.0073
Echinococcus granulosus cathepsin l1 0.0104 0.0293 0.0293
Onchocerca volvulus 0.0156 0.0502 0.1875
Plasmodium vivax aspartyl protease, putative 0.0124 0.0372 0.7304
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0347 0.0448
Plasmodium vivax vivapain-2 0.0156 0.0502 1
Echinococcus granulosus high affinity choline transporter 1 0.0638 0.2454 0.2454
Plasmodium vivax aspartyl proteinase, putative 0.0154 0.0492 0.9793
Loa Loa (eye worm) hepatopoietin HPO2 0.0038 0.0022 0.0028
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0156 0.0502 0.0648
Onchocerca volvulus 0.0638 0.2454 1
Entamoeba histolytica cysteine proteinase, putative 0.0104 0.0293 0.3182
Loa Loa (eye worm) ctsf protein 0.0156 0.0502 0.0648
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Leishmania major 0.1944 0.7746 1
Plasmodium falciparum plasmepsin IV 0.0154 0.0492 0.9793
Brugia malayi Cathepsin L-like precursor 0.0156 0.0502 0.0648
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0073 0.0073
Echinococcus multilocularis sodium:glucose cotransporter 2 0.25 1 1
Echinococcus multilocularis solute carrier family 5 0.25 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0073 0.0073
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0038 0.0022 0.0022
Onchocerca volvulus 0.0104 0.0293 0.1005
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.008 0.0195 0.0195
Brugia malayi Papain family cysteine protease containing protein 0.0156 0.0502 0.0648
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0723 0.2798 0.3595
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Plasmodium vivax plasmepsin V, putative 0.0045 0.0051 0.0611
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.0279 0.0279
Plasmodium vivax plasmepsin IV, putative 0.0154 0.0492 0.9793
Schistosoma mansoni sodium/solute symporter 0.0638 0.2454 0.2454
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.0078 0.0101
Echinococcus multilocularis cysteine protease 0.0156 0.0502 0.0502
Trypanosoma cruzi cysteine peptidase, putative 0.0156 0.0502 0.0621
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0723 0.2798 0.3595
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0052 0.0078 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1

Activities

Activity type Activity value Assay description Source Reference
MIC80 (functional) = 100 ug ml-1 Antifungal activity against Candida parapsilosis after 24 hrs ChEMBL. 16905318
MIC80 (functional) = 100 ug ml-1 Antifungal activity against Cryptococcus neoformans after 72 hrs ChEMBL. 16905318
MIC80 (functional) = 100 ug ml-1 Antifungal activity against Cryptococcus neoformans after 72 hrs ChEMBL. 16905318
MIC80 (functional) > 200 ug ml-1 Antifungal activity against Candida albicans after 24 hrs ChEMBL. 16905318
MIC80 (functional) > 200 ug ml-1 Antifungal activity against Aspergillus fumigatus after 7 days ChEMBL. 16905318
MIC80 (functional) > 200 ug ml-1 Antifungal activity against Microsporum canis after 7 days ChEMBL. 16905318
MIC80 (functional) > 200 ug ml-1 Antifungal activity against Trichophyton rubrum after 7 days ChEMBL. 16905318
MIC80 (functional) > 200 ug ml-1 Antifungal activity against Candida albicans after 24 hrs ChEMBL. 16905318

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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