Detailed information for compound 409499

Basic information

Technical information
  • TDR Targets ID: 409499
  • Name: 2-tetradecyl-3,4-dihydro-1H-isoquinoline-6,7- diol
  • MW: 361.561 | Formula: C23H39NO2
  • H donors: 2 H acceptors: 2 LogP: 7.75 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCCCCCN1CCc2c(C1)cc(c(c2)O)O
  • InChi: 1S/C23H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-24-16-14-20-17-22(25)23(26)18-21(20)19-24/h17-18,25-26H,2-16,19H2,1H3
  • InChiKey: KQZVJKOJIXKQJK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-myristyl-3,4-dihydro-1H-isoquinoline-6,7-diol
  • 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-2-tetradecyl-
  • AIDS-418168
  • AIDS418168

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii cathepsin CPL 0.0156 0.0502 0.0621
Plasmodium vivax vivapain-3 0.008 0.0195 0.361
Trypanosoma cruzi cruzipain precursor, putative 0.0052 0.0078 0.0073
Plasmodium vivax aspartyl proteinase, putative 0.0154 0.0492 0.9793
Echinococcus multilocularis cathepsin L 0.008 0.0195 0.0195
Echinococcus multilocularis sodium:glucose cotransporter 2 0.25 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0073 0.0073
Plasmodium vivax aspartyl protease, putative 0.0124 0.0372 0.7304
Plasmodium vivax vivapain-2 0.0156 0.0502 1
Brugia malayi Sodium:solute symporter family protein 0.0638 0.2454 0.3168
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0638 0.2454 0.2454
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0156 0.0502 0.0502
Brugia malayi MH2 domain containing protein 0.0118 0.0347 0.0448
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0052 0.0078 0.0101
Plasmodium vivax vivapain-2 0.0156 0.0502 1
Onchocerca volvulus 0.0156 0.0502 0.1875
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0502 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0156 0.0502 1
Onchocerca volvulus 0.0156 0.0502 0.1875
Echinococcus multilocularis cathepsin L cysteine protease 0.0156 0.0502 0.0502
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0127 0.0165
Brugia malayi Cathepsin L-like precursor 0.0052 0.0078 0.0101
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0347 0.0448
Trypanosoma cruzi cysteine peptidase, putative 0.0156 0.0502 0.0621
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0723 0.2798 0.3595
Plasmodium falciparum cysteine proteinase falcipain 3 0.0156 0.0502 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0051 0.0051
Brugia malayi hypothetical protein 0.0045 0.0051 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Schistosoma mansoni cathepsin D (A01 family) 0.0524 0.1991 0.1991
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0045 0.0051 0.0066
Leishmania major cathepsin L-like protease 0.0156 0.0502 0.0621
Brugia malayi aspartic protease BmAsp-1, identical 0.0045 0.0051 0.0066
Loa Loa (eye worm) fibroinase 0.0156 0.0502 0.0648
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0051 0.0051
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0638 0.2454 0.3149
Plasmodium vivax plasmepsin V, putative 0.0045 0.0051 0.0611
Echinococcus granulosus cathepsin L cysteine protease 0.008 0.0195 0.0195
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.0279 0.0279
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.008 0.0195 0.0224
Entamoeba histolytica cysteine proteinase, putative 0.0104 0.0293 0.3182
Brugia malayi fructose-1,6-bisphosphatase 0.1944 0.7746 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0073 0.0094
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0502 1
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0078 0.0073
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0502 1
Schistosoma mansoni jumonji domain containing protein 0.008 0.0195 0.0195
Plasmodium vivax aspartyl proteinase, putative 0.0045 0.0051 0.0611
Brugia malayi jmjC domain containing protein 0.0101 0.0279 0.036
Loa Loa (eye worm) hypothetical protein 0.0638 0.2454 0.3168
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.008 0.0195 0.0195
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0723 0.2798 0.3595
Echinococcus granulosus cathepsin L 0.008 0.0195 0.0195
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.008 0.0195 0.0195
Brugia malayi Augmenter of liver regeneration 0.0038 0.0022 0.0028
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Schistosoma mansoni memapsin-2 (A01 family) 0.0045 0.0051 0.0051
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0154 0.0492 0.0635
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0073 0.0073
Plasmodium vivax plasmepsin IV, putative 0.0154 0.0492 0.9793
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0154 0.0492 0.0492
Plasmodium vivax aspartyl protease, putative 0.0045 0.0051 0.0611
Onchocerca volvulus 0.0156 0.0502 0.1875
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0073 0.0094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0073 0.0073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0156 0.0502 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0078 0.0101
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.1944 0.7746 1
Toxoplasma gondii fructose-bisphospatase II 0.1944 0.7746 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0152 0.0196
Plasmodium falciparum cysteine proteinase falcipain 1 0.008 0.0195 0.361
Entamoeba histolytica cysteine proteinase, putative 0.0156 0.0502 1
Schistosoma mansoni cathepsin D (A01 family) 0.0524 0.1991 0.1991
Toxoplasma gondii aspartyl protease 0.0045 0.0051 0.0038
Loa Loa (eye worm) hypothetical protein 0.0052 0.0078 0.0101
Leishmania major cathepsin L-like protease 0.0156 0.0502 0.0621
Brugia malayi Cathepsin L-like precursor 0.0156 0.0502 0.0648
Leishmania major cathepsin L-like protease 0.0156 0.0502 0.0621
Plasmodium falciparum plasmepsin VII 0.0045 0.0051 0.0611
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0156 0.0502 0.0502
Plasmodium falciparum plasmepsin I 0.0154 0.0492 0.9793
Echinococcus multilocularis high affinity choline transporter 1 0.0638 0.2454 0.2454
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0154 0.0492 0.0492
Echinococcus granulosus cathepsin L cysteine proteinase 0.0156 0.0502 0.0502
Onchocerca volvulus Cathepsin F homolog 0.0156 0.0502 0.1875
Echinococcus multilocularis cysteine protease 0.0156 0.0502 0.0502
Schistosoma mansoni sodium/solute symporter 0.0638 0.2454 0.2454
Plasmodium falciparum plasmepsin IV 0.0154 0.0492 0.9793
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0073 0.0073
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.008 0.0195 0.0195
Plasmodium vivax unspecified product 0.0052 0.0078 0.1177
Loa Loa (eye worm) hypothetical protein 0.0045 0.0051 0.0066
Brugia malayi GH02984p 0.0638 0.2454 0.3168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0723 0.2798 0.3595
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0051 0.0051
Echinococcus multilocularis solute carrier family 5 0.25 1 1
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0154 0.0492 0.9675
Echinococcus granulosus sodium:myo inositol cotransporter 0.25 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0156 0.0502 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0051 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0156 0.0502 1
Schistosoma mansoni cathepsin F (C01 family) 0.0156 0.0502 0.0502
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0502 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0156 0.0502 0.0648
Loa Loa (eye worm) hypothetical protein 0.0052 0.0078 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Schistosoma mansoni eyes absent homolog 0.0097 0.0261 0.0261
Loa Loa (eye worm) hepatopoietin HPO2 0.0038 0.0022 0.0028
Brugia malayi cathepsin F-like cysteine proteinase 0.0052 0.0078 0.0101
Loa Loa (eye worm) hypothetical protein 0.0104 0.0293 0.0378
Toxoplasma gondii aspartyl protease ASP3 0.0124 0.0372 0.0454
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0154 0.0492 0.0492
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Echinococcus granulosus cathepsin l1 0.0156 0.0502 0.0502
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0021 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Trypanosoma cruzi cysteine peptidase, putative 0.0156 0.0502 0.0621
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0156 0.0502 0.0648
Schistosoma mansoni hypothetical protein 0.007 0.0152 0.0152
Leishmania major cathepsin L-like protease 0.0156 0.0502 0.0621
Leishmania major 0.1944 0.7746 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0084 0.0108
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.1944 0.7746 1
Brugia malayi Cathepsin L-like precursor 0.0104 0.0293 0.0378
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.0283 0.0365
Echinococcus granulosus high affinity choline transporter 1 0.0638 0.2454 0.2454
Brugia malayi Papain family cysteine protease containing protein 0.0156 0.0502 0.0648
Loa Loa (eye worm) hypothetical protein 0.0097 0.0261 0.0337
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0502 1
Plasmodium vivax aspartyl protease, putative 0.0124 0.0372 0.7304
Plasmodium falciparum plasmepsin V 0.0045 0.0051 0.0611
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0723 0.2798 0.3595
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0104 0.0293 0.3182
Brugia malayi cathepsin L-like precursor 0.0104 0.0293 0.0378
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.1944 0.7746 1
Schistosoma mansoni inositol transporter 0.25 1 1
Echinococcus granulosus cysteine protease 0.008 0.0195 0.0195
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0502 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0195 0.0224
Brugia malayi Cathepsin L-like precursor 0.0156 0.0502 0.0648
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0073 0.0073
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0502 1
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0043 0.0043
Trypanosoma cruzi cruzipain precursor, putative 0.0156 0.0502 0.0621
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Loa Loa (eye worm) ctsf protein 0.0156 0.0502 0.0648
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0502 1
Brugia malayi hypothetical protein 0.0097 0.0261 0.0337
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.0078 0.0101
Brugia malayi Cathepsin L-like precursor 0.0156 0.0502 0.0648
Loa Loa (eye worm) hypothetical protein 0.0638 0.2454 0.3168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Plasmodium falciparum plasmepsin II 0.0154 0.0492 0.9793
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0154 0.0492 0.0635
Trypanosoma cruzi cysteine protease, putative 0.008 0.0195 0.0224
Trypanosoma cruzi cysteine peptidase, putative 0.008 0.0195 0.0224
Trypanosoma cruzi cysteine proteinase, putative 0.008 0.0195 0.0224
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0104 0.0293 0.0351
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0051 0.0051
Plasmodium vivax vivapain-1 0.008 0.0195 0.361
Brugia malayi Papain family cysteine protease containing protein 0.008 0.0195 0.0252
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0152 0.0196
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0051 0.0051
Toxoplasma gondii fructose-bisphospatase I 0.0723 0.2798 0.3595
Brugia malayi Pepsin A precursor 0.0045 0.0051 0.0066
Echinococcus granulosus cathepsin l1 0.0104 0.0293 0.0293
Onchocerca volvulus 0.0104 0.0293 0.1005
Loa Loa (eye worm) aspartyl protease 6 0.0045 0.0051 0.0066
Onchocerca volvulus Cathepsin L homolog 0.0156 0.0502 0.1875
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0154 0.0492 0.0609
Echinococcus multilocularis cysteine protease 0.0156 0.0502 0.0502
Onchocerca volvulus Cathepsin L homolog 0.0156 0.0502 0.1875
Schistosoma mansoni cathepsin F (C01 family) 0.0104 0.0293 0.0293
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.0279 0.0279
Onchocerca volvulus 0.0156 0.0502 0.1875
Trypanosoma cruzi cysteine peptidase, putative 0.0156 0.0502 0.0621
Trypanosoma cruzi cysteine proteinase, putative 0.008 0.0195 0.0224
Brugia malayi jmjC domain containing protein 0.0037 0.0021 0.0027
Echinococcus granulosus cathepsin l cysteine peptidase 0.0156 0.0502 0.0502
Plasmodium falciparum plasmepsin IX 0.0124 0.0372 0.7304
Plasmodium falciparum plasmepsin VI 0.0154 0.0492 0.9793
Echinococcus granulosus sodium:glucose cotransporter 2 0.25 1 1
Toxoplasma gondii aspartyl protease ASP1 0.0154 0.0492 0.0609
Brugia malayi hypothetical protein 0.0045 0.0051 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Schistosoma mansoni inositol transporter 0.25 1 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0283 0.0365
Schistosoma mansoni fructose-16-bisphosphatase-related 0.1944 0.7746 0.7746
Leishmania major cathepsin L-like protease 0.0156 0.0502 0.0621
Trypanosoma brucei fructose-1,6-bisphosphatase 0.1944 0.7746 1
Brugia malayi Cathepsin L-like precursor 0.0104 0.0293 0.0378
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Echinococcus granulosus fructose 16 bisphosphatase 1 0.1944 0.7746 0.7746
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0045 0.0051 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0293 0.0378
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0021 0.0021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0073 0.0073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0021 0.0021
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0038 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0104 0.0293 0.3182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Loa Loa (eye worm) cysteine protease 0.0156 0.0502 0.0648
Loa Loa (eye worm) hypothetical protein 0.0045 0.0051 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0293 0.0378
Leishmania major cysteine peptidase A (CPA) 0.0156 0.0502 0.0621
Onchocerca volvulus 0.0156 0.0502 0.1875
Leishmania major cathepsin L-like protease 0.0156 0.0502 0.0621
Plasmodium falciparum plasmepsin III 0.0045 0.0051 0.0611
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0051 0.0051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0502 1
Plasmodium vivax unspecified product 0.008 0.0195 0.361
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.0283 0.0365
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0638 0.2454 0.2454
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.0283 0.0365
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0347 0.0448
Schistosoma mansoni cathepsin s 0.0052 0.0078 0.0078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0195 0.0224
Schistosoma mansoni cathepsin F (C01 family) 0.0156 0.0502 0.0502
Onchocerca volvulus 0.0156 0.0502 0.1875
Leishmania major cathepsin L-like protease 0.0156 0.0502 0.0621
Echinococcus multilocularis cathepsin L cysteine protease 0.0156 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0156 0.0502 0.0648
Brugia malayi Cathepsin L-like precursor 0.0156 0.0502 0.0648
Brugia malayi Cathepsin L-like precursor 0.0156 0.0502 0.0648
Brugia malayi Eukaryotic aspartyl protease family protein 0.0045 0.0051 0.0066
Brugia malayi Cathepsin L-like cysteine proteinase 0.0104 0.0293 0.0378
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0156 0.0502 1
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0038 0.0022 0.0022
Brugia malayi Cathepsin L-like precursor 0.0156 0.0502 0.0648
Brugia malayi aspartic protease BmAsp-2, identical 0.0045 0.0051 0.0066
Onchocerca volvulus 0.0156 0.0502 0.1875
Schistosoma mansoni high-affinity choline transporter 0.0638 0.2454 0.2454
Plasmodium falciparum plasmepsin X 0.0124 0.0372 0.7304
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0097 0.0261 0.0337
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Trypanosoma cruzi cysteine peptidase, putative 0.0156 0.0502 0.0621
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.1944 0.7746 0.7746
Echinococcus granulosus solute carrier family 5 0.25 1 1
Leishmania major cathepsin L-like protease 0.0156 0.0502 0.0621
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0051 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0021 0.0027
Plasmodium falciparum plasmepsin VIII, putative 0.0045 0.0051 0.0611
Entamoeba histolytica cysteine protease, putative 0.0156 0.0502 1
Brugia malayi Papain family cysteine protease containing protein 0.008 0.0195 0.0252
Onchocerca volvulus 0.0638 0.2454 1
Echinococcus multilocularis sodium:myo inositol cotransporter 0.25 1 1

Activities

Activity type Activity value Assay description Source Reference
MIC80 (functional) = 6.25 ug ml-1 Antifungal activity against Cryptococcus neoformans after 72 hrs ChEMBL. 16905318
MIC80 (functional) = 6.25 ug ml-1 Antifungal activity against Cryptococcus neoformans after 72 hrs ChEMBL. 16905318
MIC80 (functional) = 12.5 ug ml-1 Antifungal activity against Microsporum canis after 7 days ChEMBL. 16905318
MIC80 (functional) = 25 ug ml-1 Antifungal activity against Trichophyton rubrum after 7 days ChEMBL. 16905318
MIC80 (functional) = 50 ug ml-1 Antifungal activity against Candida parapsilosis after 24 hrs ChEMBL. 16905318
MIC80 (functional) = 50 ug ml-1 Antifungal activity against Candida albicans after 24 hrs ChEMBL. 16905318
MIC80 (functional) = 50 ug ml-1 Antifungal activity against Candida albicans after 24 hrs ChEMBL. 16905318
MIC80 (functional) > 200 ug ml-1 Antifungal activity against Aspergillus fumigatus after 7 days ChEMBL. 16905318

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.