Detailed information for compound 409837

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 458.595 | Formula: C28H34N4O2
  • H donors: 2 H acceptors: 2 LogP: 3.38 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CCC(=O)N1C[C@@H]2CCCN2C[C@H]1Cc1ccccc1)NCCc1c[nH]c2c1cccc2
  • InChi: 1S/C28H34N4O2/c33-27(29-15-14-22-18-30-26-11-5-4-10-25(22)26)12-13-28(34)32-20-23-9-6-16-31(23)19-24(32)17-21-7-2-1-3-8-21/h1-5,7-8,10-11,18,23-24,30H,6,9,12-17,19-20H2,(H,29,33)/t23-,24+/m0/s1
  • InChiKey: PZWWUMRKSGYBFR-BJKOFHAPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) Starlite/ChEMBL References
Homo sapiens melanocortin 4 receptor Starlite/ChEMBL References
Homo sapiens melanocortin 5 receptor Starlite/ChEMBL References
Homo sapiens melanocortin 3 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium hominis beta-catenin-like repeat protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin, beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-1 tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-4 chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi beta-tubulin, identical Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Babesia bovis tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi beta tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-2A chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-4 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-7 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein melanocortin 5 receptor 325 aa 311 aa 20.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major beta tubulin 0.0027 0.0277 0.3393
Entamoeba histolytica protein kinase, putative 0.0037 0.0426 0.0699
Onchocerca volvulus 0.005 0.0609 0.1069
Brugia malayi Cam kinase protein 1 0.0037 0.0426 0.057
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.032 0.4656 0.4655
Echinococcus multilocularis nAChR subunit 0.0173 0.2447 0.4083
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0115 0.1581 0.2541
Trypanosoma cruzi beta tubulin, putative 0.0027 0.0277 0.3393
Leishmania major protein kinase, putative 0.0037 0.0426 0.5943
Echinococcus granulosus biogenic amine 5HT receptor 0.0115 0.1581 0.2637
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0115 0.1581 0.2541
Loa Loa (eye worm) hypothetical protein 0.032 0.4656 0.4655
Echinococcus granulosus rhodopsin orphan GPCR 0.0115 0.1581 0.2637
Loa Loa (eye worm) hypothetical protein 0.032 0.4656 0.4655
Echinococcus granulosus Sugar transporter ERD6 protein 0.0017 0.0125 0.0205
Onchocerca volvulus 0.0115 0.1581 0.3214
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0014 0.0078 0.0768
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.032 0.4656 0.4655
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0037 0.0426 0.0425
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0148 0.2077 0.2775
Loa Loa (eye worm) tubulin beta-1 chain 0.0027 0.0277 0.0275
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.032 0.4656 0.7769
Loa Loa (eye worm) hypothetical protein 0.032 0.4656 0.4655
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Echinococcus multilocularis neuropeptide FF receptor 2 0.0115 0.1581 0.2637
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0274 0.3351
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.0433 0.6065
Onchocerca volvulus 0.0115 0.1581 0.3214
Plasmodium falciparum lysine--tRNA ligase 0.0027 0.0275 0.0262
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.032 0.4656 0.622
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0115 0.1581 0.2637
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0173 0.2447 0.327
Giardia lamblia Beta tubulin 0.0027 0.0277 0.5899
Brugia malayi GnHR receptor homolog 0.0115 0.1581 0.2112
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0103 0.1401 1
Giardia lamblia Hexose transporter 0.0017 0.0125 0.1385
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0299 0.0297
Echinococcus multilocularis neuropeptide receptor A26 0.0115 0.1581 0.2637
Brugia malayi G-protein coupled receptor 0.0115 0.1581 0.2112
Echinococcus granulosus nAChR subunit 0.0173 0.2447 0.4083
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.032 0.4656 0.7769
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0274 0.3351
Leishmania major myo-inositol/proton symporter (MIT) 0.0017 0.0125 0.0797
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0043 0.0506 0.7295
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0173 0.2447 0.4007
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0115 0.1581 0.2541
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0115 0.1581 0.2541
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0429 0.0714
Echinococcus granulosus 7tm_1 domain containing protein 0.0115 0.1581 0.2637
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0115 0.1581 0.2112
Echinococcus granulosus 7TM GPCR rhodopsin 0.0115 0.1581 0.2637
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0027 0.0275 0.3364
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0664 0.1187
Loa Loa (eye worm) hypothetical protein 0.0017 0.0125 0.0123
Echinococcus granulosus g protein coupled receptor 0.0115 0.1581 0.2637
Echinococcus granulosus neuropeptides capa receptor 0.0115 0.1581 0.2637
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.032 0.4656 0.7741
Echinococcus granulosus tar DNA binding protein 0.0067 0.087 0.145
Trichomonas vaginalis tubulin gamma chain, putative 0.0027 0.0277 0.1233
Echinococcus granulosus glycine receptor subunit beta 0.032 0.4656 0.7769
Brugia malayi follicle stimulating hormone receptor 0.0115 0.1581 0.2112
Trypanosoma brucei beta tubulin 0.0027 0.0277 0.3393
Echinococcus granulosus tumor protein p63 0.0339 0.4927 0.8222
Schistosoma mansoni biogenic amine receptor 0.0115 0.1581 0.2541
Leishmania major beta tubulin 0.0027 0.0277 0.3393
Echinococcus granulosus rhodopsin orphan GPCR 0.0115 0.1581 0.2637
Echinococcus multilocularis neuropeptides capa receptor 0.0115 0.1581 0.2637
Loa Loa (eye worm) tubulin beta chain 0.0027 0.0277 0.0275
Entamoeba histolytica hypothetical protein 0.0027 0.0275 0.0003
Loa Loa (eye worm) TAR-binding protein 0.0067 0.087 0.0869
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0115 0.1581 0.2541
Trichomonas vaginalis tubulin, putative 0.0027 0.0277 0.1233
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0433 0.2205
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0429 0.0594
Loa Loa (eye worm) hypothetical protein 0.0054 0.0682 0.068
Brugia malayi major facilitator superfamily protein 0.0017 0.0125 0.0167
Brugia malayi beta-tubulin, identical 0.0027 0.0277 0.037
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0197 0.2811 0.3635
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0225 0.0912
Echinococcus multilocularis fmrfamide receptor 0.0115 0.1581 0.2637
Brugia malayi AKH receptor 0.0115 0.1581 0.2112
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0115 0.1581 0.2112
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.0214 0.1027
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Loa Loa (eye worm) hypothetical protein 0.0148 0.2077 0.2075
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0037 0.0426 0.0425
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0115 0.1581 0.2637
Trichomonas vaginalis tubulin epsilon chain, putative 0.0027 0.0277 0.1233
Schistosoma mansoni hypothetical protein 0.041 0.5992 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0481 0.08
Schistosoma mansoni hypothetical protein 0.0115 0.1581 0.2541
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0092 0.1247 0.8837
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0115 0.1581 0.158
Loa Loa (eye worm) melatonin receptor type 1A 0.0115 0.1581 0.158
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0148 0.2077 0.2775
Trichomonas vaginalis glucose transporter, putative 0.0017 0.0125 0.029
Brugia malayi Tachykinin-like peptides receptor 99D 0.0115 0.1581 0.2112
Loa Loa (eye worm) hypothetical protein 0.032 0.4656 0.4655
Echinococcus granulosus neuropeptide receptor 0.0115 0.1581 0.2637
Leishmania major glucose transporter, lmgt2 0.0038 0.0433 0.6065
Brugia malayi Serotonin receptor 0.0115 0.1581 0.2112
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.032 0.4656 0.4655
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0426 0.2161
Loa Loa (eye worm) hypothetical protein 0.0017 0.0125 0.0123
Echinococcus multilocularis nAChR subunit 0.032 0.4656 0.7769
Loa Loa (eye worm) hypothetical protein 0.0027 0.0275 0.0274
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Leishmania major trypanothione reductase 0.004 0.0473 0.6738
Leishmania major glucose transporter, lmgt1 0.0038 0.0433 0.6065
Loa Loa (eye worm) hypothetical protein 0.0037 0.0415 0.0413
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.032 0.4656 0.7769
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.032 0.4656 0.7741
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0148 0.2077 0.2775
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.032 0.4656 0.7769
Onchocerca volvulus 0.0115 0.1581 0.3214
Schistosoma mansoni cpg binding protein 0.0029 0.0299 0.0373
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0682 0.1135
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.087 0.0869
Brugia malayi hypothetical protein 0.0034 0.0382 0.0511
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0426 0.0709
Echinococcus granulosus rhodopsin orphan GPCR 0.0115 0.1581 0.2637
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0115 0.1581 0.158
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Onchocerca volvulus 0.0173 0.2447 0.5127
Trichomonas vaginalis sugar transport protein, putative 0.0017 0.0125 0.029
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0115 0.1581 0.2541
Schistosoma mansoni tubulin subunit beta 0.0027 0.0277 0.0336
Brugia malayi hypothetical protein 0.0148 0.2077 0.2775
Echinococcus multilocularis orexin receptor type 2 0.0115 0.1581 0.2637
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0043 0.0506 0.7295
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.032 0.4656 0.7769
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0682 0.1135
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0017 0.0125 0.0353
Trypanosoma brucei trypanothione reductase 0.004 0.0473 0.6738
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0125 0.029
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0115 0.1581 0.2637
Onchocerca volvulus 0.0115 0.1581 0.3214
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0473 0.6738
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Brugia malayi Dopamine receptor 0.0115 0.1581 0.2112
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0277 0.0459
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0037 0.0415 0.057
Echinococcus multilocularis glycine receptor subunit beta 0.032 0.4656 0.7769
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0115 0.1581 0.2541
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0173 0.2447 0.327
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0426 0.0709
Plasmodium falciparum tubulin beta chain 0.0027 0.0277 0.0264
Brugia malayi CXXC zinc finger family protein 0.0029 0.0299 0.0399
Loa Loa (eye worm) acetylcholine receptor protein 0.0148 0.2077 0.2075
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0282 0.0281
Mycobacterium tuberculosis Probable dehydrogenase 0.0092 0.1247 0.8837
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0115 0.1581 0.2637
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0115 0.1581 0.2541
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.032 0.4656 0.7769
Trypanosoma brucei beta tubulin 0.0027 0.0277 0.3393
Loa Loa (eye worm) hypothetical protein 0.0148 0.2077 0.2075
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0115 0.1581 0.2637
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0017 0.0125 0.0062
Echinococcus granulosus solute carrier family 22 0.0017 0.0125 0.0205
Entamoeba histolytica tubulin family protein 0.0027 0.0277 0.0011
Loa Loa (eye worm) hypothetical protein 0.032 0.4656 0.4655
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.032 0.4656 0.7741
Trypanosoma brucei glucose transporter, putative 0.0038 0.0433 0.6065
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0122 0.169 0.2818
Loa Loa (eye worm) hypothetical protein 0.032 0.4656 0.4655
Loa Loa (eye worm) hypothetical protein 0.0017 0.0125 0.0123
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0014 0.0078 0.0768
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0426 0.0709
Brugia malayi hypothetical protein 0.0148 0.2077 0.2775
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0583 0.1011
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Schistosoma mansoni hypothetical protein 0.0122 0.169 0.2725
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0115 0.1581 0.2541
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0115 0.1581 0.2637
Entamoeba histolytica tubulin family protein 0.0027 0.0277 0.0011
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0481 0.08
Echinococcus multilocularis glycine receptor subunit alpha 1 0.032 0.4656 0.7769
Entamoeba histolytica hypothetical protein 0.0038 0.0429 0.0712
Schistosoma mansoni amine GPCR 0.0115 0.1581 0.2541
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0027 0.0275 0.0516
Leishmania major beta tubulin 0.0027 0.0277 0.3393
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Loa Loa (eye worm) hypothetical protein 0.051 0.7485 0.7485
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0017 0.0125 0.0797
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Echinococcus multilocularis lysyl tRNA synthetase 0.0027 0.0275 0.0457
Echinococcus granulosus calcium dependent protein kinase 0.0035 0.0392 0.0651
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0274 0.0455
Loa Loa (eye worm) hypothetical protein 0.0048 0.0583 0.0581
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0277 0.0459
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0015 0.0093 0.0091
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0115 0.1581 0.2637
Plasmodium vivax glutathione reductase, putative 0.004 0.0473 0.0525
Chlamydia trachomatis lysine--tRNA ligase 0.0027 0.0275 1
Loa Loa (eye worm) beta-tubulin 0.0027 0.0277 0.0275
Echinococcus multilocularis solute carrier family 22 0.0017 0.0125 0.0205
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0664 0.0779
Schistosoma mansoni cpg binding protein 0.003 0.0323 0.0414
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.0433 0.6065
Echinococcus multilocularis rhodopsin orphan GPCR 0.0115 0.1581 0.2637
Schistosoma mansoni acetylcholine receptor subunit beta 0.0148 0.2077 0.338
Echinococcus granulosus beta tubulin 0.0027 0.0277 0.0459
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0115 0.1581 0.2541
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0197 0.2811 0.5538
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0115 0.1581 0.2637
Loa Loa (eye worm) hypothetical protein 0.0017 0.0125 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0125 0.029
Plasmodium vivax proline--tRNA ligase, putative 0.0043 0.0506 0.0568
Plasmodium falciparum hexose transporter 0.0122 0.169 0.2143
Brugia malayi hypothetical protein 0.0053 0.0664 0.0887
Brugia malayi neuropeptide F receptor 0.0115 0.1581 0.2112
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Onchocerca volvulus 0.0029 0.0299 0.0384
Echinococcus granulosus fmrfamide receptor 0.0115 0.1581 0.2637
Toxoplasma gondii beta-tubulin, putative 0.0027 0.0277 0.0403
Echinococcus multilocularis G-protein coupled receptor, putative 0.0115 0.1581 0.2637
Leishmania major beta tubulin 0.0027 0.0277 0.3393
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Entamoeba histolytica protein kinase, putative 0.0037 0.0426 0.0699
Schistosoma mansoni growth hormone secretagogue receptor 0.0115 0.1581 0.2541
Toxoplasma gondii transporter, major facilitator family protein 0.0017 0.0125 0.0095
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0426 0.0709
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0037 0.0415 0.057
Plasmodium falciparum glutathione reductase 0.004 0.0473 0.0525
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0115 0.1581 0.2541
Loa Loa (eye worm) BEN-1 protein 0.0027 0.0277 0.0275
Brugia malayi Sugar transporter family protein 0.0017 0.0125 0.0167
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0125 0.0797
Echinococcus multilocularis dro:myosuppressin receptor 0.0115 0.1581 0.2637
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.032 0.4656 0.7769
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Toxoplasma gondii thioredoxin reductase 0.004 0.0473 0.08
Echinococcus granulosus biogenic amine 5HT receptor 0.0115 0.1581 0.2637
Onchocerca volvulus 0.0048 0.0583 0.1011
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0037 0.0427 0.0706
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0014 0.0078 0.0768
Loa Loa (eye worm) hypothetical protein 0.0148 0.2077 0.2075
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0115 0.1581 0.2637
Loa Loa (eye worm) hypothetical protein 0.0148 0.2077 0.2075
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Schistosoma mansoni nAChR subunit 0.032 0.4656 0.7741
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0115 0.1581 0.2637
Onchocerca volvulus 0.0115 0.1581 0.3214
Brugia malayi hypothetical protein 0.0115 0.1581 0.2112
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Schistosoma mansoni nAChR subunit 0.032 0.4656 0.7741
Onchocerca volvulus Putative nachr subunit 0.032 0.4656 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.087 0.134
Schistosoma mansoni sugar transporter 0.0017 0.0125 0.0079
Loa Loa (eye worm) hypothetical protein 0.0017 0.0125 0.0123
Schistosoma mansoni neurotransmitter gated ion channel 0.0148 0.2077 0.338
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0037 0.0427 0.0464
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0027 0.0275 0.3364
Echinococcus granulosus neuropeptide receptor A26 0.0115 0.1581 0.2637
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0682 0.1135
Echinococcus multilocularis solute carrier family 22 0.0017 0.0125 0.0205
Loa Loa (eye worm) hypothetical protein 0.005 0.0609 0.0607
Loa Loa (eye worm) hypothetical protein 0.032 0.4656 0.4655
Loa Loa (eye worm) hypothetical protein 0.0173 0.2447 0.2446
Echinococcus granulosus solute carrier family 22 0.0017 0.0125 0.0205
Echinococcus granulosus neuropeptide s receptor 0.0115 0.1581 0.2637
Brugia malayi Sugar transporter family protein 0.0122 0.169 0.2258
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.032 0.4656 0.622
Echinococcus multilocularis neuropeptide s receptor 0.0115 0.1581 0.2637
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Brugia malayi excitatory GABA receptor EXP-1A 0.032 0.4656 0.622
Plasmodium falciparum calcium-dependent protein kinase 1 0.0037 0.0427 0.0464
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Loa Loa (eye worm) hypothetical protein 0.0173 0.2447 0.2446
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Echinococcus granulosus solute carrier family 22 0.0017 0.0125 0.0205
Schistosoma mansoni tubulin subunit beta 0.0027 0.0277 0.0336
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0022 0.003
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0583 0.097
Schistosoma mansoni neurotransmitter gated ion channel 0.0173 0.2447 0.4007
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0092 0.1247 0.8837
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0125 0.029
Echinococcus granulosus synaptic vesicle 2 protein 0.0017 0.0125 0.0205
Echinococcus multilocularis serotonin receptor 0.0115 0.1581 0.2637
Echinococcus granulosus tubulin beta 1 chain 0.0027 0.0277 0.0459
Brugia malayi Cation transporter family protein 0.032 0.4656 0.622
Trichomonas vaginalis tubulin epsilon chain, putative 0.0027 0.0277 0.1233
Plasmodium vivax hexose transporter 0.0122 0.169 0.2143
Echinococcus multilocularis rhodopsin orphan GPCR 0.0115 0.1581 0.2637
Schistosoma mansoni tar DNA-binding protein 0.0067 0.087 0.134
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0043 0.0506 0.7295
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0433 0.2205
Leishmania major hypothetical protein, conserved 0.0017 0.0125 0.0797
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0609 0.0898
Giardia lamblia Beta tubulin 0.0027 0.0277 0.5899
Echinococcus multilocularis rhodopsin orphan GPCR 0.0115 0.1581 0.2637
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0017 0.0125 0.2954
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0277 0.0459
Schistosoma mansoni nAChR subunit 0.032 0.4656 0.7741
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0122 0.169 0.2818
Echinococcus granulosus rhodopsin orphan GPCR 0.0115 0.1581 0.2637
Echinococcus granulosus General substrate transporter 0.0105 0.1434 0.2391
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.032 0.4656 0.622
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.032 0.4656 0.7741
Echinococcus multilocularis beta tubulin 0.0027 0.0277 0.0459
Brugia malayi G protein-coupled receptor 0.0115 0.1581 0.2112
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.032 0.4656 0.4655
Echinococcus granulosus tachykinin peptides receptor 99D 0.0115 0.1581 0.2637
Echinococcus multilocularis G protein coupled receptor 139 0.0115 0.1581 0.2637
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0148 0.2077 0.2075
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Loa Loa (eye worm) hypothetical protein 0.0148 0.2077 0.2075
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0092 0.1247 0.8837
Loa Loa (eye worm) hypothetical protein 0.0017 0.0125 0.0123
Echinococcus granulosus dro:myosuppressin receptor 0.0115 0.1581 0.2637
Schistosoma mansoni opsin-like receptor 0.0115 0.1581 0.2541
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0277 0.0459
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.169 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0115 0.1581 0.2637
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Entamoeba histolytica hypothetical protein 0.0173 0.2447 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.032 0.4656 0.622
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0148 0.2077 0.2775
Loa Loa (eye worm) hypothetical protein 0.0017 0.0125 0.0123
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0037 0.0426 0.0709
Leishmania major glucose transporter, lmgt3 0.0038 0.0433 0.6065
Echinococcus multilocularis neuropeptide receptor 0.0115 0.1581 0.2637
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Loa Loa (eye worm) hypothetical protein 0.0017 0.0125 0.0123
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0583 0.097
Toxoplasma gondii lysine-tRNA ligase 0.0027 0.0275 0.0399
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0274 0.0398
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0664 0.0779
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.032 0.4656 0.622
Echinococcus granulosus dnaJ subfamily B 0.041 0.5992 1
Leishmania major beta tubulin 0.0027 0.0277 0.3393
Leishmania major beta tubulin 0.0027 0.0277 0.3393
Schistosoma mansoni sugar transporter 0.0017 0.0125 0.0079
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Echinococcus multilocularis tubulin subunit beta 0.0027 0.0277 0.0459
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0037 0.0415 0.0647
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Brugia malayi putative neuropeptide receptor NPR1 0.0115 0.1581 0.2112
Echinococcus multilocularis glycine receptor subunit alpha 1 0.032 0.4656 0.7769
Brugia malayi major facilitator superfamily protein 0.0017 0.0125 0.0167
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.032 0.4656 0.7769
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0037 0.0415 0.0554
Loa Loa (eye worm) hypothetical protein 0.0173 0.2447 0.2446
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0103 0.1401 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0027 0.0277 0.1233
Leishmania major beta tubulin 0.0027 0.0277 0.3393
Trichomonas vaginalis myo-inositol transporter, putative 0.0017 0.0125 0.029
Loa Loa (eye worm) hypothetical protein 0.0017 0.0125 0.0123
Leishmania major glucose transporter/membrane transporter D2, putative 0.0038 0.0433 0.6065
Echinococcus granulosus glycine receptor subunit alpha 1 0.032 0.4656 0.7769
Loa Loa (eye worm) hypothetical protein 0.032 0.4656 0.4655
Schistosoma mansoni neuropeptide f receptor 76f 0.0115 0.1581 0.2541
Plasmodium vivax lysine--tRNA ligase, putative 0.0027 0.0275 0.0262
Leishmania major beta tubulin 0.0027 0.0277 0.3393
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0115 0.1581 0.2637
Loa Loa (eye worm) hypothetical protein 0.032 0.4656 0.4655
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0037 0.0427 0.0464
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.032 0.4656 0.7769
Loa Loa (eye worm) hypothetical protein 0.032 0.4656 0.4655
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Echinococcus granulosus alpha 1A adrenergic receptor 0.0115 0.1581 0.2637
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Loa Loa (eye worm) hypothetical protein 0.0148 0.2077 0.2075
Schistosoma mansoni opsin-like receptor 0.0115 0.1581 0.2541
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.032 0.4656 0.7769
Leishmania major beta tubulin 0.0027 0.0277 0.3393
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0125 0.0167
Loa Loa (eye worm) hypothetical protein 0.0148 0.2077 0.2075
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0664 0.0779
Schistosoma mansoni hypothetical protein 0.0038 0.0429 0.0594
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0781 0.1188
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0188 0.2683 0.4476
Echinococcus multilocularis tubulin beta 1 chain 0.0027 0.0277 0.0459
Onchocerca volvulus 0.032 0.4656 1
Schistosoma mansoni tubulin subunit beta 0.0027 0.0277 0.0336
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0426 0.0589
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0277 0.0459
Brugia malayi Cation transporter family protein 0.032 0.4656 0.622
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0092 0.1247 0.8704
Echinococcus granulosus glycine receptor subunit alpha 1 0.032 0.4656 0.7769
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.032 0.4656 0.622
Loa Loa (eye worm) hypothetical protein 0.0362 0.5277 0.5276
Plasmodium vivax CDK-related protein kinase 6, putative 0.0517 0.7598 1
Leishmania major beta tubulin 0.0027 0.0277 0.3393
Mycobacterium ulcerans sugar transporter 0.0017 0.0125 0.2954
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Loa Loa (eye worm) hypothetical protein 0.0017 0.0125 0.0123
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.032 0.4656 0.622
Echinococcus granulosus neuropeptide FF receptor 2 0.0115 0.1581 0.2637
Echinococcus multilocularis rhodopsin orphan GPCR 0.0115 0.1581 0.2637
Schistosoma mansoni hypothetical protein 0.0024 0.0225 0.0249
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Echinococcus multilocularis rhodopsin orphan GPCR 0.0115 0.1581 0.2637
Schistosoma mansoni tubulin subunit beta 0.0027 0.0277 0.0336
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0277 0.0459
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0115 0.1581 0.158
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0148 0.2077 0.3464
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0043 0.0506 0.0866
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Echinococcus granulosus g protein coupled receptor 0.0115 0.1581 0.2637
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0583 0.0853
Echinococcus granulosus glycine receptor subunit beta 0.032 0.4656 0.7769
Entamoeba histolytica hypothetical protein 0.0038 0.0429 0.0712
Brugia malayi sulfakinin receptor protein 0.0115 0.1581 0.2112
Schistosoma mansoni biogenic amine (5HT) receptor 0.0115 0.1581 0.2541
Onchocerca volvulus 0.032 0.4656 1
Onchocerca volvulus 0.0148 0.2077 0.4308
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0017 0.0125 0.0079
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0115 0.1581 0.2541
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0115 0.1581 0.2637
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0122 0.169 0.2818
Schistosoma mansoni nAChR subunit 0.032 0.4656 0.7741
Loa Loa (eye worm) hypothetical protein 0.0017 0.0125 0.0123
Leishmania major hypothetical protein, conserved 0.0053 0.0664 1
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0148 0.2077 0.2775
Loa Loa (eye worm) RNA binding protein 0.0067 0.087 0.0869
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0583 0.0853
Schistosoma mansoni opsin-like receptor 0.0115 0.1581 0.2541
Trichomonas vaginalis glucose transporter, putative 0.0038 0.0433 0.2205
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0275 0.0333
Onchocerca volvulus 0.032 0.4656 1
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0125 0.0167
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0023 0.0214 0.1027
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0274 0.0273
Leishmania major beta tubulin 0.0027 0.0277 0.3393
Loa Loa (eye worm) tubulin beta-2A chain 0.0027 0.0277 0.0275
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.032 0.4656 0.7769
Plasmodium vivax calcium-dependent protein kinase, putative 0.0037 0.0427 0.0464
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0115 0.1581 0.2637
Loa Loa (eye worm) sugar transporter 0.0122 0.169 0.1688
Entamoeba histolytica hypothetical protein 0.0038 0.0429 0.0712
Leishmania major lysyl-tRNA synthetase, putative 0.0027 0.0275 0.3364
Echinococcus multilocularis g protein coupled receptor 0.0115 0.1581 0.2637
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0148 0.2077 0.3464
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0037 0.0415 0.069
Toxoplasma gondii facilitative glucose transporter GT1 0.0122 0.169 0.3265
Brugia malayi hypothetical protein 0.0115 0.1581 0.2112
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0274 0.1218
Echinococcus granulosus rhodopsin orphan GPCR 0.0115 0.1581 0.2637
Leishmania major beta tubulin 0.0027 0.0277 0.3393
Loa Loa (eye worm) hypothetical protein 0.0037 0.0415 0.0413
Schistosoma mansoni adenoreceptor 0.0115 0.1581 0.2541
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0115 0.1581 0.2541
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Toxoplasma gondii sugar transporter ST1 0.0017 0.0125 0.0095
Schistosoma mansoni neuropeptide F-like receptor 0.0115 0.1581 0.2541
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Brugia malayi hypothetical protein 0.0148 0.2077 0.2775
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.032 0.4656 0.622
Echinococcus multilocularis cpg binding protein 0.003 0.0323 0.0537
Echinococcus granulosus hypothetical protein 0.0115 0.1581 0.2637
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0122 0.169 0.2818
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0148 0.2077 0.3464
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0115 0.1581 0.2541
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0037 0.0415 0.2091
Schistosoma mansoni flap endonuclease-1 0.0025 0.0235 0.0266
Echinococcus granulosus orexin receptor type 2 0.0115 0.1581 0.2637
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Loa Loa (eye worm) BEN-1 protein 0.0027 0.0277 0.0275
Brugia malayi hypothetical protein 0.0115 0.1581 0.2112
Schistosoma mansoni alpha-1 adrenergic receptor 0.0115 0.1581 0.2541
Brugia malayi hypothetical protein 0.0148 0.2077 0.2775
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0277 0.0459
Loa Loa (eye worm) hypothetical protein 0.032 0.4656 0.4655
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0037 0.0427 0.0706
Loa Loa (eye worm) hypothetical protein 0.0148 0.2077 0.2075
Brugia malayi RNA binding protein 0.0067 0.087 0.1163
Echinococcus granulosus tm gpcr rhodopsin 0.0115 0.1581 0.2637
Echinococcus multilocularis tumor protein p63 0.0339 0.4927 0.8222
Schistosoma mansoni histamine h1 receptor 0.0115 0.1581 0.2541
Echinococcus granulosus rhodopsin orphan GPCR 0.0115 0.1581 0.2637
Onchocerca volvulus 0.0115 0.1581 0.3214
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0682 0.1021
Plasmodium falciparum protein kinase 6 0.0517 0.7598 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.2077 0.2075
Schistosoma mansoni sugar transporter 0.0017 0.0125 0.0079
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0115 0.1581 0.2112
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.032 0.4656 0.7741
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0037 0.0426 0.057
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0115 0.1581 0.158
Loa Loa (eye worm) hypothetical protein 0.0017 0.0125 0.0123
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Echinococcus granulosus rhodopsin orphan GPCR 0.0115 0.1581 0.2637
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0115 0.1581 0.2637
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0103 0.1401 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Schistosoma mansoni cpg binding protein 0.003 0.0323 0.0414
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0037 0.0415 0.069
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0017 0.0125 0.2954
Onchocerca volvulus 0.0173 0.2447 0.5127
Loa Loa (eye worm) sugar transporter 0.0017 0.0125 0.0123
Mycobacterium tuberculosis Probable oxidoreductase 0.0103 0.1401 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0125 0.0123
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Echinococcus granulosus tm gpcr rhodopsin 0.0115 0.1581 0.2637
Mycobacterium ulcerans integral membrane transport protein 0.0017 0.0125 0.2954
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0115 0.1581 0.2541
Loa Loa (eye worm) hypothetical protein 0.0148 0.2077 0.2075
Loa Loa (eye worm) neuropeptide F receptor 0.0115 0.1581 0.158
Loa Loa (eye worm) hypothetical protein 0.0017 0.0125 0.0123
Plasmodium vivax tubulin beta chain, putative 0.0027 0.0277 0.0264
Giardia lamblia Beta tubulin 0.0027 0.0277 0.5899
Schistosoma mansoni nAChR subunit 0.0148 0.2077 0.338
Schistosoma mansoni hypothetical protein 0.0115 0.1581 0.2541
Schistosoma mansoni tar DNA-binding protein 0.0067 0.087 0.134
Trypanosoma cruzi hexose transporter, putative 0.0021 0.0177 0.1695
Loa Loa (eye worm) hypothetical protein 0.032 0.4656 0.4655
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0027 0.0277 0.0459
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0274 0.5827
Echinococcus granulosus flap endonuclease 1 0.0027 0.0274 0.0455
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Onchocerca volvulus 0.0115 0.1581 0.3214
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.032 0.4656 0.7769
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0426 0.0709
Schistosoma mansoni glucose transport protein 0.0122 0.169 0.2725
Echinococcus granulosus neuropeptide Y receptor 0.0115 0.1581 0.2637
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0583 0.0581
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0225 0.0373
Plasmodium falciparum thioredoxin reductase 0.004 0.0473 0.0525
Brugia malayi mbt repeat family protein 0.0048 0.0583 0.0779
Onchocerca volvulus 0.0148 0.2077 0.4308
Schistosoma mansoni nAChR subunit 0.032 0.4656 0.7741
Schistosoma mansoni myosin xvIII 0.0115 0.1581 0.2541
Schistosoma mansoni glucose transporter 0.0017 0.0125 0.0079
Trypanosoma brucei glucose transporter, putative 0.0038 0.0433 0.6065
Echinococcus multilocularis rhodopsin orphan GPCR 0.0115 0.1581 0.2637
Trypanosoma cruzi glucose transporter, putative 0.0017 0.0125 0.0797
Loa Loa (eye worm) hypothetical protein 0.0148 0.2077 0.2075
Giardia lamblia Prolyl-tRNA synthetase 0.0037 0.0415 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0429 0.0714
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0014 0.0078 0.0768
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0017 0.0125 0.0205
Echinococcus granulosus neuropeptide receptor 0.0115 0.1581 0.2637
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.032 0.4656 0.622
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.051 0.7485 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0115 0.1581 0.158
Giardia lamblia Lysyl-tRNA synthetase 0.0027 0.0275 0.5849
Leishmania major beta tubulin 0.0027 0.0277 0.3393
Plasmodium falciparum calcium-dependent protein kinase 2 0.0037 0.0427 0.0464
Brugia malayi Flap endonuclease-1 0.0027 0.0274 0.0367
Trypanosoma brucei glucose transporter 1E 0.0038 0.0433 0.6065
Echinococcus multilocularis fmrfamide receptor 0.0115 0.1581 0.2637
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.032 0.4656 0.7741
Echinococcus multilocularis solute carrier family 22 0.0017 0.0125 0.0205
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0275 1
Echinococcus multilocularis sex peptide receptor 0.0115 0.1581 0.2637
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0115 0.1581 0.2541
Onchocerca volvulus 0.0115 0.1581 0.3214
Loa Loa (eye worm) MBCTL1 0.0054 0.0682 0.068
Brugia malayi mbt repeat family protein 0.0048 0.0583 0.0779
Loa Loa (eye worm) hypothetical protein 0.0173 0.2447 0.2446
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0115 0.1581 0.2541
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.032 0.4656 0.622
Plasmodium falciparum calcium-dependent protein kinase 5 0.0037 0.0427 0.0464
Schistosoma mansoni tubulin subunit beta 0.0027 0.0277 0.0336
Loa Loa (eye worm) hypothetical protein 0.032 0.4656 0.4655
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Loa Loa (eye worm) hypothetical protein 0.0148 0.2077 0.2075
Echinococcus granulosus lysyl tRNA synthetase 0.0027 0.0275 0.0457
Schistosoma mansoni neuropeptide receptor 0.0115 0.1581 0.2541
Brugia malayi Melatonin receptor type 1A 0.0115 0.1581 0.2112
Loa Loa (eye worm) hypothetical protein 0.0148 0.2077 0.2075
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.0078 0.0128
Echinococcus multilocularis glycine receptor subunit alpha 1 0.032 0.4656 0.7769
Echinococcus multilocularis neuropeptide receptor 0.0115 0.1581 0.2637
Trichomonas vaginalis glucose transporter, putative 0.0038 0.0433 0.2205
Echinococcus granulosus cpg binding protein 0.003 0.0323 0.0537
Loa Loa (eye worm) G-protein coupled receptor 0.0115 0.1581 0.158
Brugia malayi ORL1-like opioid receptor 0.0115 0.1581 0.2112
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0115 0.1581 0.2637
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0115 0.1581 0.2637
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0125 0.029
Loa Loa (eye worm) hypothetical protein 0.0173 0.2447 0.2446
Schistosoma mansoni biogenic amine receptor 0.0115 0.1581 0.2541
Trypanosoma brucei glucose transporter 2A 0.0038 0.0433 0.6065
Onchocerca volvulus 0.0115 0.1581 0.3214
Echinococcus granulosus tm gpcr rhodopsin 0.0115 0.1581 0.2637
Schistosoma mansoni hypothetical protein 0.0115 0.1581 0.2541
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0426 0.0709
Schistosoma mansoni neuropeptide F-like receptor 0.0115 0.1581 0.2541
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0043 0.0506 0.7295
Brugia malayi Dopamine receptor protein 1 0.0115 0.1581 0.2112
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0122 0.169 0.2818
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0275 0.0333
Loa Loa (eye worm) LGC-31 protein 0.032 0.4656 0.4655
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0125 0.0123
Echinococcus multilocularis dnaJ subfamily B 0.041 0.5992 1
Onchocerca volvulus 0.0115 0.1581 0.3214
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0022 0.003
Brugia malayi hypothetical protein 0.0017 0.0125 0.0167
Plasmodium falciparum protein kinase 7 0.0344 0.5014 0.6564
Loa Loa (eye worm) hypothetical protein 0.0148 0.2077 0.2075
Leishmania major beta tubulin 0.0027 0.0277 0.3393
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0037 0.0427 0.0706
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0433 0.6065
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0043 0.0506 0.7295
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0683 0.1226
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0148 0.2077 0.3464
Brugia malayi lysyl-tRNA synthetase 0.0027 0.0275 0.0368
Schistosoma mansoni amine GPCR 0.0115 0.1581 0.2541
Brugia malayi Cytochrome P450 family protein 0.0028 0.0282 0.0377
Brugia malayi TAR-binding protein 0.0067 0.087 0.1163
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0115 0.1581 0.2637
Echinococcus multilocularis glycine receptor subunit beta 0.032 0.4656 0.7769
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0277 0.0459
Echinococcus multilocularis synaptic vesicle 2 protein 0.0017 0.0125 0.0205
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0473 0.2985
Echinococcus granulosus tubulin subunit beta 0.0027 0.0277 0.0459
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0037 0.0415 0.1695
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0277 0.0459
Echinococcus multilocularis rhodopsin orphan GPCR 0.0115 0.1581 0.2637
Onchocerca volvulus 0.032 0.4656 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.087 0.134
Brugia malayi hypothetical protein 0.0017 0.0125 0.0167
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0115 0.1581 0.2541
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0275 1
Echinococcus multilocularis beta tubulin 0.0027 0.0277 0.0459
Schistosoma mansoni protein kinase 0.0037 0.0426 0.0589
Toxoplasma gondii sugar transporter ST2 0.0017 0.0125 0.0095
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.0433 0.6065
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0115 0.1581 0.2112
Brugia malayi hypothetical protein 0.0115 0.1581 0.2112
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.0078 0.0104
Schistosoma mansoni protein kinase 0.0037 0.0426 0.0589
Loa Loa (eye worm) hypothetical protein 0.032 0.4656 0.4655
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0583 0.097
Toxoplasma gondii beta-1 tubulin, putative 0.0027 0.0277 0.0403
Trypanosoma brucei sugar transporter, putative 0.0017 0.0125 0.0797
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0173 0.2447 0.327
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0148 0.2077 0.3464
Loa Loa (eye worm) tubulin beta-4 chain 0.0027 0.0277 0.0275
Schistosoma mansoni hypothetical protein 0.0291 0.4209 0.6986
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Schistosoma mansoni acetylcholine receptor-related 0.0148 0.2077 0.338
Schistosoma mansoni hypothetical protein 0.0115 0.1581 0.2541
Loa Loa (eye worm) hypothetical protein 0.0173 0.2447 0.2446
Brugia malayi hypothetical protein 0.0148 0.2077 0.2775
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Schistosoma mansoni amine GPCR 0.0115 0.1581 0.2541
Brugia malayi hypothetical protein 0.0038 0.0429 0.0573
Brugia malayi G-protein coupled receptor 0.0115 0.1581 0.2112
Schistosoma mansoni tubulin subunit beta 0.0027 0.0277 0.0336
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0115 0.1581 0.2541
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0473 0.0525
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0664 1
Brugia malayi neuropeptide F receptor 0.0115 0.1581 0.2112
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0037 0.0426 0.5943
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0583 0.0853
Brugia malayi hypothetical protein 0.0115 0.1581 0.2112
Plasmodium falciparum calcium-dependent protein kinase 3 0.0037 0.0427 0.0464
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.032 0.4656 0.7769
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0125 0.0123
Brugia malayi putative neuropeptide receptor 0.0115 0.1581 0.2112
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0433 0.2205
Echinococcus granulosus beta tubulin 0.0027 0.0277 0.0459
Trypanosoma brucei glucose transporter, putative 0.0038 0.0433 0.6065
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0433 0.2205
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0274 0.3351
Loa Loa (eye worm) ACC-1 protein 0.032 0.4656 0.4655
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0583 0.097
Toxoplasma gondii beta tubulin 0.0027 0.0277 0.0403
Echinococcus granulosus somatostatin receptor 0.0115 0.1581 0.2637
Echinococcus granulosus peptide allatostatin:somatostatin 0.0115 0.1581 0.2637
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0148 0.2077 0.2075
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0148 0.2077 0.2775
Echinococcus multilocularis General substrate transporter 0.0105 0.1434 0.2391
Schistosoma mansoni amine GPCR 0.0115 0.1581 0.2541
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0122 0.169 0.2818
Onchocerca volvulus 0.0115 0.1581 0.3214
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.032 0.4656 0.622
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0274 0.0261
Echinococcus granulosus solute carrier family 22 0.0017 0.0125 0.0205
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0115 0.1581 0.2637
Loa Loa (eye worm) hypothetical protein 0.032 0.4656 0.4655
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0017 0.0125 0.0353
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0037 0.0415 0.0554
Brugia malayi hypothetical protein 0.0115 0.1581 0.2112
Schistosoma mansoni neuropeptide receptor 0.0115 0.1581 0.2541
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0115 0.1581 0.3214
Trypanosoma brucei beta tubulin 0.0027 0.0277 0.3393
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0682 0.1135
Echinococcus granulosus neuropeptide Y receptor 0.0115 0.1581 0.2637
Loa Loa (eye worm) hypothetical protein 0.0173 0.2447 0.2446
Trypanosoma brucei glucose transporter, putative 0.0038 0.0433 0.6065
Echinococcus granulosus g protein coupled receptor 0.0115 0.1581 0.2637
Echinococcus multilocularis neuropeptide Y receptor 0.0115 0.1581 0.2637
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0433 0.2205
Loa Loa (eye worm) hypothetical protein 0.0053 0.0664 0.0662
Echinococcus multilocularis neuropeptide Y receptor 0.0115 0.1581 0.2637
Leishmania major beta tubulin 0.0027 0.0277 0.3393
Echinococcus multilocularis g protein coupled receptor 0.0115 0.1581 0.2637
Giardia lamblia Sugar-proton symporter 0.0017 0.0125 0.1385
Schistosoma mansoni biogenic amine receptor 0.0115 0.1581 0.2541
Echinococcus multilocularis neuropeptides capa receptor 0.0115 0.1581 0.2637
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0682 0.0911
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0173 0.2447 0.4007
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0115 0.1581 0.2637
Onchocerca volvulus 0.0115 0.1581 0.3214
Onchocerca volvulus Neuropeptide F receptor homolog 0.0115 0.1581 0.3214
Echinococcus granulosus g-protein coupled receptor 0.0115 0.1581 0.2637
Brugia malayi larval opioid receptor 0.0115 0.1581 0.2112
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.087 0.1163
Leishmania major beta tubulin 0.0027 0.0277 0.3393
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0426 0.0709
Plasmodium falciparum proline--tRNA ligase 0.0043 0.0506 0.0568
Loa Loa (eye worm) hypothetical protein 0.0037 0.0426 0.0425
Trypanosoma cruzi sugar transporter, putative 0.0017 0.0125 0.0797
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.032 0.4656 0.622
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0027 0.0275 0.1223
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Loa Loa (eye worm) hypothetical protein 0.0173 0.2447 0.2446
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0122 0.169 0.2818
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0433 0.6065
Schistosoma mansoni sugar transporter 0.0017 0.0125 0.0079
Brugia malayi Cation transporter family protein 0.032 0.4656 0.622
Loa Loa (eye worm) hypothetical protein 0.0148 0.2077 0.2075
Schistosoma mansoni neurotransmitter gated ion channel 0.0148 0.2077 0.338
Trypanosoma brucei beta tubulin 0.0027 0.0277 0.3393
Echinococcus multilocularis tar DNA binding protein 0.0067 0.087 0.145
Echinococcus granulosus neuropeptides capa receptor 0.0115 0.1581 0.2637
Loa Loa (eye worm) neuropeptide F receptor 0.0115 0.1581 0.158
Brugia malayi Serotonin receptor 0.0115 0.1581 0.2112
Loa Loa (eye worm) hypothetical protein 0.003 0.0313 0.0311
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0115 0.1581 0.2541
Trichomonas vaginalis tubulin beta chain, putative 0.0027 0.0277 0.1233
Loa Loa (eye worm) GABA receptor subunit 0.0173 0.2447 0.2446
Trypanosoma brucei glucose transporter, putative 0.0038 0.0433 0.6065
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0188 0.2683 0.4476
Onchocerca volvulus 0.0115 0.1581 0.3214
Loa Loa (eye worm) hypothetical protein 0.032 0.4656 0.4655
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.032 0.4656 0.622
Leishmania major beta tubulin 0.0027 0.0277 0.3393
Echinococcus multilocularis g-protein coupled receptor 0.0115 0.1581 0.2637
Brugia malayi Sugar transporter family protein 0.0017 0.0125 0.0167
Onchocerca volvulus 0.032 0.4656 1
Trypanosoma brucei glucose transporter, putative 0.0038 0.0433 0.6065
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0125 0.0167
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Schistosoma mansoni protein kinase 0.0037 0.0426 0.0589
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Onchocerca volvulus 0.0115 0.1581 0.3214
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0122 0.169 0.2818
Loa Loa (eye worm) hypothetical protein 0.0017 0.0125 0.0123
Brugia malayi hypothetical protein 0.0115 0.1581 0.2112
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0017 0.0125 1
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0473 0.0471
Toxoplasma gondii sugar transporter ST3 0.0017 0.0125 0.0095
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.032 0.4656 0.4655
Onchocerca volvulus 0.032 0.4656 1
Brugia malayi Tubulin beta-1 chain 0.0027 0.0277 0.037
Echinococcus multilocularis calcium dependent protein kinase 0.0035 0.0392 0.0651
Loa Loa (eye worm) glutathione reductase 0.004 0.0473 0.0471
Plasmodium falciparum mitogen-activated protein kinase 2 0.0197 0.2811 0.3635
Brugia malayi hypothetical protein 0.0115 0.1581 0.2112
Schistosoma mansoni nAChR subunit 0.032 0.4656 0.7741
Schistosoma mansoni biogenic amine (5HT) receptor 0.0115 0.1581 0.2541
Brugia malayi Thioredoxin reductase 0.004 0.0473 0.0632
Brugia malayi G protein-coupled receptor F59B2.13 0.0115 0.1581 0.2112
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0037 0.0427 0.0464
Schistosoma mansoni neuropeptide receptor 0.0115 0.1581 0.2541
Schistosoma mansoni glucose transport protein 0.0122 0.169 0.2725
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0664 1
Echinococcus multilocularis serotonin receptor 0.0115 0.1581 0.2637
Echinococcus granulosus sex peptide receptor 0.0115 0.1581 0.2637
Treponema pallidum NADH oxidase 0.0014 0.0078 1
Onchocerca volvulus 0.0115 0.1581 0.3214
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Onchocerca volvulus 0.0115 0.1581 0.3214
Echinococcus granulosus G protein coupled receptor 139 0.0115 0.1581 0.2637
Plasmodium falciparum flap endonuclease 1 0.0027 0.0274 0.0261
Schistosoma mansoni neuropeptide receptor 0.0115 0.1581 0.2541
Schistosoma mansoni nAChR subunit 0.032 0.4656 0.7741
Entamoeba histolytica hypothetical protein 0.0038 0.0429 0.0712
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0092 0.1247 0.8837
Schistosoma mansoni glucose transport protein 0.0122 0.169 0.2725
Schistosoma mansoni amine GPCR 0.0115 0.1581 0.2541
Leishmania major beta tubulin 0.0027 0.0277 0.3393
Echinococcus multilocularis somatostatin receptor 0.0115 0.1581 0.2637
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0664 1
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.032 0.4656 0.7769
Loa Loa (eye worm) TYRA-2 protein 0.0115 0.1581 0.158
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0433 0.6065
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0225 0.0373
Echinococcus multilocularis solute carrier family 22 0.0017 0.0125 0.0205
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0115 0.1581 0.2637
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0115 0.1581 0.2112
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.0078 0.0128
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0115 0.1581 0.2541
Mycobacterium tuberculosis Probable reductase 0.0092 0.1247 0.8837
Plasmodium vivax sugar transporter, putative 0.0017 0.0125 0.0062
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0125 0.029
Echinococcus granulosus allatostatin A receptor 0.0115 0.1581 0.2637
Schistosoma mansoni tar DNA-binding protein 0.0067 0.087 0.134
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Toxoplasma gondii protein kinase, putative 0.0344 0.5014 1
Loa Loa (eye worm) hypothetical protein 0.032 0.4656 0.4655
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.032 0.4656 0.7769
Loa Loa (eye worm) G-protein coupled receptor 0.0115 0.1581 0.158
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.032 0.4656 0.622
Echinococcus multilocularis allatostatin A receptor 0.0115 0.1581 0.2637
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0173 0.2447 0.327
Echinococcus granulosus serotonin receptor 0.0115 0.1581 0.2637
Plasmodium falciparum calcium-dependent protein kinase 4 0.0037 0.0427 0.0464
Brugia malayi Dopamine receptor protein 2 0.0115 0.1581 0.2112
Trypanosoma cruzi hexose transporter 0.0038 0.0433 0.6065
Onchocerca volvulus 0.0148 0.2077 0.4308
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0277 0.0459
Onchocerca volvulus 0.0115 0.1581 0.3214
Loa Loa (eye worm) hypothetical protein 0.0115 0.1581 0.158
Echinococcus granulosus tubulin beta 4A class IVa 0.0027 0.0277 0.0459
Trypanosoma brucei glucose transporter, putative 0.0038 0.0433 0.6065
Echinococcus granulosus nAChR subunit 0.032 0.4656 0.7769
Loa Loa (eye worm) ACC-1 protein 0.032 0.4656 0.4655
Brugia malayi hypothetical protein 0.0115 0.1581 0.2112
Brugia malayi hypothetical protein 0.0115 0.1581 0.2112
Echinococcus multilocularis g protein coupled receptor 0.0115 0.1581 0.2637
Brugia malayi glutathione reductase 0.004 0.0473 0.0632
Echinococcus granulosus glycine receptor subunit alpha 1 0.032 0.4656 0.7769
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0125 0.029
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.032 0.4656 0.622
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0115 0.1581 0.2541
Trypanosoma brucei glucose transporter, putative 0.0038 0.0433 0.6065
Brugia malayi hypothetical protein 0.0017 0.0125 0.0167
Brugia malayi RE15519p 0.0115 0.1581 0.2112
Schistosoma mansoni nAChR subunit 0.0148 0.2077 0.338
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.032 0.4656 0.4655

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 0 % Activity at human MC1R expressed in HEK293 cells assessed as activation of adenylate cyclase ChEMBL. 16931008
Activity (functional) = 0 % Activity at human MC3R expressed in HEK293 cells assessed as activation of adenylate cyclase ChEMBL. 16931008
Activity (functional) = 0 % Activity at human MC5R expressed in HEK293 cells assessed as activation of adenylate cyclase ChEMBL. 16931008
Activity (functional) = 0 % Activity at human MC4R expressed in HEK293 cells assessed as activation of adenylate cyclase ChEMBL. 16931008
Activity (functional) = 0 % Activity at human MC1R expressed in HEK293 cells assessed as activation of adenylate cyclase ChEMBL. 16931008
Activity (functional) = 0 % Activity at human MC3R expressed in HEK293 cells assessed as activation of adenylate cyclase ChEMBL. 16931008
Activity (functional) = 0 % Activity at human MC5R expressed in HEK293 cells assessed as activation of adenylate cyclase ChEMBL. 16931008
Activity (functional) = 0 % Activity at human MC4R expressed in HEK293 cells assessed as activation of adenylate cyclase ChEMBL. 16931008
Activity (binding) = 60 % Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells relative to MT-II ChEMBL. 16931008
Activity (binding) = 60 % Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells relative to MT-II ChEMBL. 16931008
EC50 (functional) > 10000 nM Activity at human MC1R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulation ChEMBL. 16931008
EC50 (functional) > 10000 nM Activity at human MC3R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulation ChEMBL. 16931008
EC50 (functional) > 10000 nM Activity at human MC5R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulation ChEMBL. 16931008
EC50 (functional) > 10000 nM Activity at human MC4R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulation ChEMBL. 16931008
EC50 (functional) > 10000 nM Activity at human MC1R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulation ChEMBL. 16931008
EC50 (functional) > 10000 nM Activity at human MC3R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulation ChEMBL. 16931008
EC50 (functional) > 10000 nM Activity at human MC5R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulation ChEMBL. 16931008
EC50 (functional) > 10000 nM Activity at human MC4R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulation ChEMBL. 16931008
IC50 (binding) = 0.1 nM Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells ChEMBL. 16931008
IC50 (binding) = 0.1 nM Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in HEK293 cells ChEMBL. 16931008
IC50 (binding) > 10000 nM Displacement of [125I]NDP-alpha-MSH from human MC4R expressed in HEK293 cells ChEMBL. 16931008
IC50 (binding) > 10000 nM Displacement of [125I]NDP-alpha-MSH from human MC1R expressed in HEK293 cells ChEMBL. 16931008
IC50 (binding) > 10000 nM Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells ChEMBL. 16931008
IC50 (binding) > 10000 nM Displacement of [125I]NDP-alpha-MSH from human MC4R expressed in HEK293 cells ChEMBL. 16931008
IC50 (binding) > 10000 nM Displacement of [125I]NDP-alpha-MSH from human MC1R expressed in HEK293 cells ChEMBL. 16931008
IC50 (binding) > 10000 nM Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells ChEMBL. 16931008

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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